JP2009233557A - Harmful material removing material and air cleaning apparatus using the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a harmful material removing material which catches and inactivates harmful materials such as bacteria, mold, viruses, pollen and allergen and inhibits a used chicken egg antibody from re-breeding the bacteria or mold, and an air cleaning apparatus mounted with an antibody filter composed of such the harmful material removing material. <P>SOLUTION: In the harmful material removing material, (A) the chicken egg antibody and (B) a silver salt of an organic compound, in which the logarithmic value (pK<SB>sp</SB>) of the inverse of a solubility product at pH7 and 25°C is 8 to 14, are carried by a carrier. The air cleaning apparatus uses the provided material. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a harmful substance removing material, and more specifically, a chicken egg antibody and a silver salt of an organic compound are supported on a carrier, and selectively capture and inactivate various harmful substances such as bacteria, viruses and allergens. It relates to a hazardous substance removal material.

  In recent years, in various industries such as the semiconductor manufacturing industry, pharmaceutical manufacturing industry, food processing, offices, hospitals, nursing homes for the elderly and in the consumer sector, there has been an increasing demand for cleanliness, safety, and hygiene in the workplace and living environment. The reality is. For this reason, more than ever, various devices and products with antibacterial and antifungal functions are widely used in air purification filter members for clean room air filters, food processing and air conditioning for offices, and home air conditioners. Used / provided.

  In particular, infectious diseases of specific viruses are prevalent in facilities such as hospitals and nursing homes for the elderly, and an immediate countermeasure is required. From these backgrounds, it is desired to develop a treatment member that has both a high removal function for these specific viruses and a function capable of dealing with a wide range of bacteria and sputum.

  For example, Patent Document 1 discloses a harmful substance that captures harmful substances such as bacteria, mold, viruses, and allergens floating in a gas phase atmosphere by using a harmful substance removing agent that uses an antibody and a carrier that has been subjected to anti-fouling treatment. Substance removal materials have been proposed.

Further, Patent Document 2 describes a method for producing a harmful substance removing material for a wide range of bacteria and sputum, but measures against specific viruses are insufficient.
JP 2004-313755 A JP-A-9-328402

  Higher hazardous substance removal performance is required for hazardous substance removal materials. As described above, in the conventional technique using an antibody and a carrier subjected to anti-epileptic processing, the antibody itself tends to be deteriorated by the antibacterial / anti-anti-elastogenic material.

  An object of the present invention is to provide a harmful substance removing agent that has the ability to remove a specific virus at a higher rate and the ability to remove a wide variety of bacteria and sputum.

As a result of diligent studies to achieve the above object, the present inventor made a fibrous carrier carrying an egg antibody carry a silver salt of an organic compound, so that the bacteria captured by the carrier were inactive. Furthermore, the present invention was completed by finding that no new pupae or bacteria were propagated on this carrier.
That is, the present invention has the following configuration.

<1>
(A) a chicken egg antibody;
(B) a silver salt of an organic compound having a logarithmic value (pK _sp ) of the reciprocal of the solubility product at pH 7 and 25 ° C. of 8 to 14,
Hazardous substance removal material with carrier supported

<2>
The harmful substance removing material according to <1>, wherein the organic compound is a nitrogen-containing heterocyclic compound or a fatty acid.

<3>
The organic compound is any one of a benzotriazole compound, a triazolopyrimidine compound, and a linear saturated fatty acid having 14 to 22 carbon atoms, described above <1> or <2> .

<4>
The harmful substance removing agent according to any one of <1> to <3>, wherein the antibody is an avian egg antibody.

<5>
The air cleaner using the hazardous | toxic substance removal material in any one of said <1>-<4>.

  According to the present invention, it is possible to effectively capture and inactivate harmful substances such as bacteria, sputum, viruses, pollen and allergens, and to provide a harmful substance removing material having an antibacterial effect without deteriorating chicken egg antibodies. it can.

  In the following, embodiments of the hazardous substance removing material and the air cleaning device of the present invention will be described in more detail.

<Carrier>
The carrier used for the hazardous substance removing material of the present invention is not particularly limited, but a carrier constituted by fibers is preferable, and the carrier can be constituted in the form of a woven fabric, a nonwoven fabric or the like. Examples of the fibers include, but are not limited to, synthetic fibers such as polyester, cellulose ester, polyvinyl alcohol, vinylon, acrylic, polyurethane, polyamide, natural fibers such as cotton, silk, wool, and regenerated fibers such as rayon. I can do it. These fibers may be combined. For the purpose of improving the strength and dimensional stability, the carrier may be reinforced with other suitable structural materials such as metals, polymer materials, and ceramics. These reinforcing materials are desirably used for portions other than the substantially outermost surface of the side surface to which the harmful substance removing material is supplied (for example, used on the opposite surface of the side surface or a core material).

The fiber used as a carrier in the present invention can be produced by a general production method such as melt spinning, wet spinning, dry spinning, wet drying spinning, or physical treatment (for example, strong mechanical shearing treatment using an ultra-high pressure homogenizer). In order to ensure stable quality, it is preferable to use dry spinning or wet-dry spinning. In order to produce uniform fibers with an average fiber diameter of 100 nm or less, further processing techniques, 2005, 40, No. 2, 101, and 167; Polymer International, 1995, 36, 195- 201; Polymer Preprints, 2000, 41 (2), 1193; Journal of Macromolecular Science: Physics, 1997, B36, 169, etc. It is preferable to employ the electrospinning method.

  Solvents used for spinning include chlorinated solvents such as methylene chloride, chloroform and dichloroethane, amide solvents such as dimethylformamide, dimethylacetamide and N-methylpyrrolidone, and ketones such as acetone, ethyl methyl ketone, methyl isopropyl ketone and cyclohexanone. Any solvent that dissolves the resin used for the synthetic resin fiber, such as a solvent, an ether solvent such as THF or diethyl ether, an alcohol solvent such as methanol, ethanol, or isopropanol, or water can be used. These solvents may be used alone or in combination of two or more.

  When the electrospinning method is employed, a salt such as lithium chloride, lithium bromide, potassium chloride, or sodium chloride may be further added to the resin solution.

  It is desirable that the fibers constituting the carrier have a structure in which a three-dimensional network is formed by partial adhesion. By adopting such a structure, it is possible to improve processing and practical mechanical resistance, and to improve the reliability of the hazardous substance removing material. Moreover, the retention property of an antibody can be improved. The adhesion between fibers can be observed by a method such as SEM. The density of the bonding points between the fibers is preferably 10 or more per 1 mm square with respect to the projected surface area of the harmful substance removing material, and more preferably 100 or more.

  As a method for forming an adhesion point, it may be formed by an adhesion formed by a dry spinning method or a fusion point formed by a melt spinning method, or after spinning, addition of an adhesive, a plasticizing solvent, etc. You may perform the adhesion point formation process by. From the viewpoint of production cost, it is preferable to form adhesion points by a dry spinning method using an appropriate solution formulation.

The carrier is preferably sterilized. The sterilization method is not particularly limited as long as the sterilization method does not deteriorate the carrier, but sterilization by radiation or sterilization by gas is preferable.
Examples of radiation sterilization methods include gamma sterilization and electron beam sterilization. Among these, the method using gamma ray sterilization is preferable.
Examples of the gas sterilization method include methods using ethylene oxide gas sterilization and chlorine dioxide gas sterilization. Among these, the method using ethylene oxide gas sterilization is preferable.

<(A) Egg antibody>
The egg egg antibody used in the present invention is a protein that specifically reacts (antigen-antibody reaction) with a specific harmful substance (antigen), and usually has a molecular size of 7 to 8 nm and has a Y-shaped molecule. It has a form. Of the Y-shaped molecular structure of an antibody, a pair of branch parts is called Fab and a trunk part is called Fc, and among these, a toxic substance is captured at the Fab part.

  The type of the antibody corresponds to the type of harmful substance that can be captured. Examples of harmful substances captured by antibodies include bacteria, molds, viruses, allergens, and mycoplasmas. Specifically, examples of bacteria include gram-positive bacteria, Staphylococcus (S. aureus and Staphylococcus epidermidis), micrococcus, anthrax, cereus, Bacillus subtilis, acne, and gram-negative bacteria. And Pseudomonas aeruginosa, Serratia, Sephacia, Streptococcus pneumoniae, Legionella, and Mycobacterium tuberculosis. Examples of molds include Aspergillus, Penicillius, and Cladosporium. Examples of the virus include influenza virus, coronavirus (SARS virus), adenovirus, rhinovirus and the like. Examples of allergens include pollen, mite allergen, cat allergen and the like.

Examples of the method for producing the antibody include, for example, a method in which an antigen is administered to an animal such as a goat, horse, sheep, or rabbit, and a polyclonal antibody is purified from the blood, and a spleen cell and a cultured cancer cell of the animal to which the antigen is administered. Methods for purifying monoclonal antibodies from cell cultures and body fluids (such as ascites) of animals that have been transplanted with the cultures, purified antibodies from genetically modified bacteria, plant cells, or animal cell cultures into which antibody-producing genes have been introduced And a method for purifying avian egg antibodies from egg yolk powder obtained by administering an antigen to birds to produce immunized eggs and sterilizing and spray-drying the yolk liquid. Among these, the method of obtaining an antibody from an avian egg can easily obtain a large amount of the antibody and can reduce the cost of a harmful substance removing material. Examples of birds include chickens and ostriches.
An avian egg antibody can be obtained by purifying an egg yolk powder obtained by administering an antigen to a bird to produce an immunized egg, and sterilizing and spray-drying the yolk liquid. In the method of obtaining antibodies from avian eggs, antibodies can be obtained easily and in large quantities, and the cost of the harmful substance removing material can be reduced.

  As a method of supporting (immobilizing) the antibody on the carrier, in addition to a method of physically adsorbing the antibody on the carrier, the carrier is silanized using γ-aminopropyltriethoxysilane and the like, and then glutarylated. A method of introducing an aldehyde group onto the surface of the carrier with aldehyde or the like and covalently bonding the aldehyde group and the antibody, a method of immobilizing the antibody on the carrier by ionic bonding by immersing an untreated carrier in an aqueous solution of the antibody, a specific method A method of introducing an aldehyde group into a carrier having a functional group and covalently bonding the aldehyde group and the antibody, a method of ion-binding the antibody to a carrier having a specific functional group, and coating the carrier with a polymer having a specific functional group A method of introducing an aldehyde group later and covalently binding the aldehyde group to the antibody can be mentioned.

Here, examples of the specific functional group include an NHR group (R is any alkyl group other than H, methyl, ethyl, propyl, and butyl), NH ₂ group, C ₆ H ₅ NH ₂ group, and CHO group. , COOH group, and OH group.

  Also, there is a method in which the functional group on the surface of the carrier is converted to another functional group using BMPA (N-β-Maleimidopropionic acid) or the like, and then the functional group and the antibody are covalently bonded (SH group in BMPA). Are converted to COOH groups).

  Furthermore, there is a method in which a molecule (Fc receptor, protein A / G, etc.) that selectively binds to the Fc portion of the antibody is introduced onto the surface of the carrier and the antibody Fc is bound thereto. In this case, the Fab that captures the harmful substance faces outward with respect to the carrier, and the probability of contact of the harmful substance with the Fab increases, so that the harmful substance can be efficiently captured.

The antibody may be supported on a carrier via a linker. In this case, the degree of freedom of the antibody on the carrier is increased and access to harmful substances is facilitated, so that high removal performance can be obtained. Examples of the linker include bi- or higher-valent cross-linking reagents, specifically maleimide, NHS (N-Hydroxysuccinimidyl) ester, imide ester, EDC (1-Ethyl-3- [3-dimethylaminopropyl] carbodiimido), There is PMPI (N- [p-Maleimidophenyl] isocyanate), which is selective to target functional groups (SH group, NH ₂ group, COOH group, OH group) and non-selective. Moreover, the distance (space arm) between crosslinks also changes for every crosslink reagent, and it can select in the range of about 0.1 nm-3.5 nm according to the target antibody. From the viewpoint of efficiently capturing harmful substances, those that bind to the Fc of the antibody as a linker are preferred.

  As a method for introducing a linker, either a method in which a linker is bound to an antibody and then further bound to the antibody, or a method in which a linker is bound to a carrier and the antibody is bound to the linker on the carrier is possible. is there.

The antibody is supported on the carrier by attaching the solution containing the egg egg antibody to the carrier. The method for attaching the chicken egg antibody solution to the carrier is not particularly limited, and examples thereof include a method of immersing the carrier in the chicken egg antibody solution, spray coating, ink jet coating, and curtain coating.
What is necessary is just to produce the solution containing a chicken egg antibody by melt | dissolving the chicken egg antibody obtained as mentioned above in physiological saline or phosphate buffered saline. The concentration of the chicken egg antibody in the solution may be 0.001% by mass to 10% by mass, preferably 0.005% by mass to 5% by mass, and more preferably 0.01% by mass to 1% by mass. The solution may contain additives such as stabilizers, antibacterial agents and antifungal agents.

  In the present invention, it is preferable to use a solution containing a chicken egg antibody after filtering with a filter having a pore size of 0.5 μm or less. By filtering with a filter having a pore size of 0.5 μm or less, it is possible to suppress the growth of germs and molds in the produced harmful substance removing material.

<(B) Silver salt of organic compound>
The hazardous substance removing material of the present invention contains a silver salt (B) of an organic compound having a logarithmic value (pK _sp ) of the reciprocal of the solubility product at pH 7 and 25 ° C. of 8-14.
The silver salt (B) of the organic compound is preferably a hardly soluble salt, and its ionization / silver ion concentration in a saturated solution system at pH 7 is a logarithmic value (pK _sp ) of the reciprocal of its solubility product (25 ° C.). This is a silver salt of a specific organic compound characterized by being in the range of pK _sp = 8-14.

When this pK _sp value is less than 8, the silver ion concentration increases, the silver ions attacking the antibody increase, and the destruction of the antibody occurs. On the other hand, if the pK _sp value is greater than 14, the silver ion concentration becomes too low and the desired antibacterial effect cannot be obtained.

  The pKsp of a silver salt (organic silver salt) of an organic compound is, for example, Chapter 1 of the Theory of the Photographic Process by THJames, Macmillan Publishing Co. Inc., New York (fourth edition, 1977), paragraphs 7-10. Is disclosed. It can select suitably with reference to this and can be set as the silver salt (B) of the organic compound of this invention.

  The organic silver salt is described in Research Disclosure Magazine Nos. 17029 and 29963. About a manufacturing method, Unexamined-Japanese-Patent No. 2000-187298 (Fujifilm) etc. have description. The organic compound is preferably a nitrogen-containing heterocyclic compound or a fatty acid, and more preferably a benzotriazole compound, a triazolopyrimidine compound, or a linear saturated fatty acid having 14 to 22 carbon atoms. Specific examples thereof include benzotriazole silver, 5-methyl-1,3,4-triazaindolizin-7-ol silver, silver behenate, and the like.

  In the production method of the present invention, a dispersion of a silver salt of an organic compound is attached to a carrier to be supported on the carrier. The method of attaching is not particularly limited, and examples thereof include a method of immersing a carrier in a silver salt dispersion of an organic compound, spray coating, ink jet coating, and curtain coating. A binder is preferably used for the silver salt dispersion of the organic compound. The binder is preferably a water-soluble binder, and examples thereof include polyvinyl alcohol, polyvinyl pyrrolidone, gelatin, and carboxymethyl cellulose. In addition, it is more preferable to mix the antibody solution and the dispersion of the organometallic silver salt and then carry the mixture on a carrier because the manufacturing process can be simplified.

<How to use>
The hazardous substance removing material obtained by the production method of the present invention can remove harmful substances in the gas phase or liquid phase. This harmful substance removing material can be used even in a dry environment where the antibody faces the gas phase, and can be used for a filter for an air cleaner, a mask, a wipe sheet, and the like. The hazardous substance removing material obtained by the production method of the present invention can be stably stored for a long period of time.
The hazardous substance removing material obtained by the production method of the present invention is preferably packaged using a package that does not transmit ultraviolet rays. By using such a package, it is possible to prevent the deterioration of the antibody due to ultraviolet rays, and further stable storage for a long period of time is possible. As a package, an aluminum foil film and an aluminum vapor deposition film are preferable, and a multilayer film containing these is also preferably used.

<Manufacture of hazardous substance removal material>
The antibody and the organic silver salt may be applied by separately applying the antibody solution and the organic silver solution, or may be applied as an antibody-organic silver mixed solution. The latter is preferable from the viewpoint of simplification of the process. The application amount of the antibody and organic silver salt depends on the purpose of use, but it is preferable that the antibody and the organic silver salt are applied in an amount sufficient to remove harmful substances during the period of use.

  The present invention will be described in more detail with reference to the following examples. However, the present invention is not limited to these examples.

  In the present invention, using the prepared nonwoven carrier N-1, the antibody alone and the coating solution-1 to coating solution-5 containing various organic silver solutions are prepared, and the antibody and the organic silver salt are supported. Then, including the hazardous substance removing material according to the present invention, filters F-1 to F-8 [Examples: F-2, F-3, F-4, F-6, Comparative Examples: F-1, F- 5, F-7, F-8]. Next, virus inactivation and antibacterial activity were evaluated for these antibody filters, and the results are shown in Table 1.

<Toxic substance removal filter production>
<Preparation of carrier nonwoven fabric (carrier N-1)>
Acetone: water (97: 3) solution (25% by mass) of cellulose acetate (manufactured by Aldrich, total substitution degree 2.4, number average molecular weight 30,000) is heated to 60 ° C., and from a nozzle having a diameter of 0.1 mm, A nonwoven fabric was formed by jetting together with air at a spinning speed of 500 m / m to obtain a nonwoven fabric carrier N-1 having a thickness of 85 μm. The spinning cylinder was heated to 100 ° C. with a heater. It was 8 micrometers when the average fiber diameter was measured by SEM.

<Preparation of antibody coating solution (coating solution-1 to coating solution-8)>
Coating solution-1: The yolk solution of the immunized egg produced by the chicken administered with the antigen was spray-dried to obtain a dried egg yolk powder. Next, the dried egg yolk powder was degreased with ethanol to remove the degreasing component, and then dried under reduced pressure to obtain a degreased egg yolk powder as an antibody substance. When this defatted egg yolk powder was refine | purified and the purity of the influenza virus antibody (IgY antibody) was measured, it was 3 mass%. Subsequently, the defatted egg yolk powder was suspended in purified water to prepare a coating solution prepared so as to have an antibody concentration of 100 ppm.

Coating liquid-2: A liquid prepared by mixing the coating liquid-1 with a benzotriazole silver dispersion and adjusting the benzotriazole silver concentration to 100 ppm was designated as coating liquid-2.
Coating solution-3: 5-methyl-1,3,4-triazaindolizine-7-ol silver dispersion was mixed with coating solution-1, and 5-methyl-1,3,4-triazaindolizine was mixed. A solution adjusted to have a -7-ol silver concentration of 115 ppm (according to the number of moles of benzotriazole silver) was designated as Coating Solution-3.
Coating solution-4: A solution prepared by mixing a coating solution-1 with a behenic acid (carbon number: 22) silver dispersion so as to have a silver behenate concentration of 200 ppm (according to the number of moles of benzotriazole silver) It was set to 4.

Coating liquid-5: Lauric acid (carbon number: 12) silver dispersion was mixed with coating liquid-1, and a liquid adjusted to a silver laurate concentration of 137 ppm (molar number adjusted to benzotriazole silver) was applied to the coating liquid. It was set to 5.
Coating liquid-6: A liquid prepared by mixing myristic acid (carbon number: 14) silver dispersion with coating liquid-1 and adjusting to a silver behenate concentration of 149 ppm (according to the number of moles of benzotriazole silver) It was set to 6.
Coating solution-7: A solution prepared by mixing a serotonic acid (carbon number: 26) silver dispersion with coating solution-1 and adjusting the silver behenate concentration to 225 ppm (according to the number of moles of benzotriazole silver) coating solution- It was set to 7.
Coating solution-8: A solution prepared by mixing the coating solution-1 with a zeolite silver dispersion and adjusting the silver behenate concentration to 8000 ppm (according to the number of moles of silver in benzotriazole silver) was designated coating solution-7.

<Preparation of antibody filter (filter F-1 to fill F-8)>
(Filter F-1)
Carrier N-1 was immersed in coating solution-1 at room temperature for 5 minutes to give antibodies to the fiber carrier surface. The obtained sample was compressed with a roller having a surface pressure of 10 MPa, and the water content was measured and found to be 500%. Furthermore, when it was dried in an atmosphere of 50 ° C. and 30% RH until the water content became 1% or less, the water content reached 1% after 1 hour.
(Filters F-2 to F-8)
Filters F-2 to F in which an antibody and an organic silver salt are added to the fiber carrier surface in the same manner as filter F-1, except that antibody coating liquid-1 is changed to coating liquid-2 to coating liquid-7 -7 was produced.

<Evaluation of virus inactivation efficiency>
For filters F-1 to F-8, the virus inactivation efficiency was evaluated immediately after sample preparation.
As the test virus solution, purified influenza virus diluted 10 times with PBS (virus concentration 200,000 plaques / mL) was used. Each of the samples was cut into 5 cm squares and attached and fixed in the center of the virus spray test apparatus. The test virus solution was put in a nebulizer installed on the upstream side, and a virus recovery device was attached on the downstream side. Compressed air was sent from an air compressor, and the test virus was sprayed from the nebulizer spray port. A gelatin filter was installed on the downstream side of the mask, and air in the test apparatus was sucked at a suction flow rate of 10 L / min for 5 minutes to collect passing virus mist.
After the test, the gelatin filter collecting the virus was collected, and the virus infectivity after passing through the sample was determined by the TCID50 method (50% cell infectious dose measurement method) using MDCK cells. From the comparison of the virus infectivity value of the gelatin filter with and without the sample, the transient removal rate of the virus of each sample was calculated. The results are shown in Table 1.
Table 1 shows the logarithm of the reciprocal of the solubility product of the organic silver salt carried on each sample at pH 7 and 25 ° C. = pK _sp .

<Antimicrobial evaluation>
For the filters F-1 to F-8, an antibacterial activity test was performed immediately after sample preparation. The test method conformed to JIZ2801: 2000.

(Staphylococcus aureus)
The test bacteria were Staphylococcus aureus subsp. Pre-cultured on a standard agar medium. Aureus NBRC 12732 (Staphylococcus aureus) was used. The culture was dispersed and diluted with 1/500 neutral broth to prepare a test bacterial solution. 0.4 mL of this test bacterial solution was inoculated into each filter placed in a sterile petri dish, and cultured at 35 ° C. for 24 hours. After culturing, the bacteria were washed from each test cloth with 10 mL of soybean / casein / digest / broth containing lecithin / polysorbate 80, and the number of bacteria in each test cloth was measured by an agar plate culture method. Moreover, when the number of bacteria immediately after inoculation was measured, it was 1.8 × 10 ⁵ .

(Black koji mold)
As a test bacterium, Aspergillus niger NBRC 6341 (black koji mold) pre-cultured on a potato dextrose agar medium was used. The culture was diluted with 0.005% sodium dioctyl sulfosuccinate solution to prepare a test bacterial solution. 0.4 mL of this test bacterial solution was inoculated into each filter placed in a sterile petri dish and cultured at 25 ° C. for 24 hours. After culturing, the bacteria were washed from each test cloth with 10 mL of soybean / casein / digest / broth containing lecithin / polysorbate 80, and the number of bacteria in each test cloth was measured by an agar plate culture method. Moreover, when the number of bacteria immediately after inoculation was measured, it was 3.0 × 10 ⁵ .

As is clear from Table 1, the antibody filter obtained by the production method of the present invention has a high virus removal rate immediately after sample preparation. Moreover, the antibacterial effect and the antifungal effect were provided by the organic silver compound. At 12 carbon atoms, pK _sp was low, and it was considered that antibody inactivation by ionization / silver ions occurred and the inactivation efficiency by the antibody decreased. In carbon atoms 26, pK _sp is high, the antimicrobial effect is lost. It was thought that the sustained release of ionization and silver ions was suppressed as the solubility product increased. In addition, it was suggested that zeolite silver, which is not organic silver, is inferior in antifungal effect and that an organic substance can provide an antifungal effect.

<Usage example>
Filters F-2 to F-5 shown in Table 1 were attached to an air purifier MC809-W manufactured by Daikin.

Claims (5)

(A) a chicken egg antibody;
(B) a silver salt of an organic compound having a logarithmic value (pK _sp ) of the reciprocal of the solubility product at pH 7 and 25 ° C. of 8 to 14,
Hazardous substance removal material with carrier supported   The hazardous substance removing material according to claim 1, wherein the organic compound is a nitrogen-containing heterocyclic compound or a fatty acid.   The hazardous substance removing material according to claim 1 or 2, wherein the organic compound is any one of a benzotriazole compound, a triazolopyrimidine compound, and a linear saturated fatty acid having 14 to 22 carbon atoms.   The harmful substance removing agent according to any one of claims 1 to 3, wherein the antibody is an avian egg antibody.   The air cleaner using the harmful substance removal material in any one of Claims 1-3.