JP2009225742A - Isolator - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To improve the work efficiency of an isolator. <P>SOLUTION: The isolator 100 includes a working chamber 10 for performing a work on a biogenic material, a reader 22 placed in the working chamber 10 and reading information from a wireless tag storing information on an operated object for the work, and a work controlling part 30 to acquire the information read by the reader 22 and control the work. The work controlling part 30 acquires the information on the operated object read by the reader 22 and controls the works such as the motion control of instruments connected to the isolator 100, the preparation of the history of the work performed in the working chamber 10 and the final decision of the work process. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to an isolator.

  A lot of equipment such as pipettes, culture solutions, washing solutions, reagents, cells to be worked on, etc. are used for work on biological materials such as cell culture and cell treatment, and the number of work steps can be complicated. Many. For this reason, there is a possibility that so-called human errors such as cell mistakes and erroneous operations by the operator may occur.

  For example, research on regenerative medicine that cultivates cells collected from a living body and regenerates lost living tissue has been active recently, but regenerative medicine sometimes deals with multiple cells from different cell providers. The association between cell donors and cultured cells must be strictly controlled. In addition, a high quality is required for living tissues such as cells used for medical treatment. Here, high quality means that there is no contamination and that the level having a desired function is high, and the creation and management of a strict work history is required to guarantee this. .

  On the other hand, for example, when performing operations such as cell culture and cell treatment, an IC tag storing an identification number for a cell stored in the storage container is attached to each storage container that stores the cell, A cell management system to be managed has been proposed (see Patent Document 1).

Also, identification information is provided on the equipment used for the cell culture operation, and the identification information provided on each equipment at the equipment insertion port is read with a reader to check whether the equipment is necessary for the work. A safety cabinet has been proposed (see Patent Document 2).
JP 2005-332046 A JP 2007-74919 A JP 2002-347937 A

  According to the conventional configuration disclosed in Patent Documents 1 and 2, it is possible to prevent cell mix-up and manage whether necessary equipment is prepared. However, it is not possible to manage which equipment should be used in each work process among the equipment inserted into the work chamber. As described above, operations such as cell culture are complicated with many equipment and processes. Therefore, the worker often proceeds with work after confirming the work process chart for each work process.

  By the way, there is an isolator as an apparatus for performing a work on a biological material such as cell culture that is required to be an aseptic environment. The isolator has a work room in an aseptic environment inside, and an operator works with a hand inserted in a work glove provided on the front surface of the work room. For this reason, when working with an isolator, the operator may have to remove his / her hand from the work glove to check the work schedule. If this is repeated for each work process, the work efficiency is improved. It will decline. In addition, it is important to create a work history from the viewpoint of human error prevention, but in the work with an isolator, the worker often has to remove his hand from the work glove in order to create the work history, Work efficiency will decrease.

  Some isolators are equipped with equipment used for work in the work chamber, such as a centrifuge, an incubator for cell culture, and the like. The operation of these devices may have to be performed with the hand removed from the work glove, which reduces work efficiency. Further, when the device is operated with a hand inserted in the work glove, the operator cannot perform the operation smoothly, and the work efficiency is lowered.

  When the work efficiency is lowered in the work with the isolator, the work time becomes longer, which may cause damage to cells and may cause human error.

  The present invention has been made in view of such recognition by the inventor, and an object thereof is to provide a technique capable of improving the working efficiency of an isolator.

  One embodiment of the present invention is an isolator. This isolator includes a work room for performing work on biological material, a reader that is provided in the work room, reads information from a wireless tag that stores information associated with an operation target in the work, and a reader And a work management unit that acquires the read information and manages the work.

  According to this aspect, the working efficiency of the isolator can be improved.

  In the above aspect, a work glove for performing work in the work chamber may be further provided on the front side of the work chamber, and the leader may be provided in the work glove.

  Further, in the above aspect, the operation target includes a device used in the work that is attached to the work room, the wireless tag is provided in at least one place of the work room, the device, or the work glove, and information includes the operation of the device The work management unit may include an operation control unit that acquires information read by the reader and controls the operation of the device based on the acquired information.

  Further, in the above aspect, the apparatus further includes a control switch that controls the operation of the device, and the operation control unit includes information read by the reader and a signal transmitted from the control switch that permits the operation of the device specified by the information. When the device is acquired, the operation of the device may be controlled. Further, the apparatus further includes a monitor that displays the operation menu of the device to the worker, and the operation control unit displays the operation menu of the device on the monitor and enables the operation menu to be selected based on the information read by the reader. The selected operation may be performed.

  In the above aspect, the operation target includes equipment used in the work chamber, the wireless tag is provided for each equipment, the information includes identification information of the equipment, and the work management unit is read by a reader. A history creation unit that sequentially creates and stores a history of work performed in the work room based on the obtained information.

  Further, in the above aspect, the image processing apparatus further includes an imaging unit that images the inside of the work chamber, and the history creation unit acquires an image captured by the imaging unit at a predetermined timing based on a timing at which the information read by the reader is acquired. , It may be stored in association with the created history. Information may be read by a reader when an operator grips an instrument through a work glove.

  Further, in the above aspect, the information processing unit further includes an information storage unit that stores work process information of the work, and the work management unit performs the next operation among the information read by the reader and the work process information stored in advance in the information storage unit. You may have the process monitoring part which compares the information of the work process which should be performed, and judges the correctness of the work performed by the operator. Moreover, the monitor which displays work process information to an operator may further be provided, and a process monitoring part may display the work process information stored in the information storage part on a monitor.

  A combination of the above-described elements as appropriate can also be included in the scope of the invention for which patent protection is sought by this patent application.

  According to the present invention, it is possible to improve the working efficiency of the isolator.

  The present invention will be described below based on preferred embodiments with reference to the drawings. The same or equivalent components, members, and processes shown in the drawings are denoted by the same reference numerals, and repeated descriptions are omitted as appropriate. The embodiments do not limit the invention but are exemplifications, and all features and combinations thereof described in the embodiments are not necessarily essential to the invention.

(Embodiment 1)
FIG. 1 is a schematic diagram illustrating a configuration of an isolator 100 according to the first embodiment.
As shown in FIG. 1, the isolator 100 according to the first embodiment includes a work chamber 10 for performing work on a biological material such as cell processing such as cell isolation and differentiation induction or cell culture. A front door 12 is provided on the front side of the work chamber 10 so as to be openable and closable, and a work glove 20 for working in the work chamber 10 is directed toward the work chamber 10 at a predetermined position of the front door 12. Is provided. The operator can work in the work chamber 10 through the work glove 20 by inserting a hand into the work glove 20 through the opening 14 provided in the front door 12. The inside of the work chamber 10 is in an aseptic environment, and the worker inserts his / her hand into the work glove 20 and works through the work glove 20 with the front door 12 closed during the work. Therefore, the aseptic environment in the work chamber 10 is maintained even during work. Here, the aseptic environment refers to an environment that is almost as dust-free aseptic in order to avoid contamination other than substances necessary for work in the work room. The number of work gloves 20 is not particularly limited, and may be three or more, for example.

  In the work chamber 10, a reader 22 that reads information from a wireless tag that stores information associated with an operation target in the work is provided. In the present embodiment, a leader 22 is provided in the work glove 20 in the work chamber 10. The leader 22 is preferably provided in the tip region of the work glove 20, for example, the palm, the back of the hand, the fingertip, and the like. The reader 22 is an RFID reader, for example, and the wireless tag is an RFID tag. The isolator 100 also includes a work management unit 30 that acquires information read by the reader 22 and manages work. The work management unit 30 has a ROM (Read Only Memory) (not shown) that stores a control program and various data. In addition, the work management unit 30 has a CPU (Central Processing Unit) (not shown) that controls the operation of the isolator 100 and the operation of a device to be described later according to a control program stored in the ROM. Furthermore, the work management unit 30 has a RAM (Random Access Memory) (not shown) that provides a work area for temporarily storing various data during control processing by the CPU. The work management unit 30 reads out a control program stored in the ROM into the RAM, and performs various controls by the CPU processing based on the control program. In the ROM, image information to be displayed on the monitor 40 described later, position information of the cursor image 42, and the like are stored. The work management unit 30 and the reader 22 are connected by wire or wirelessly.

  The working chamber 10 is equipped with a centrifuge 200 used as a device for working in the working chamber 10 when collecting cells. In addition, the work chamber 10 is provided with an incubator 300 for culturing cells in a gas, temperature and humidity environment suitable for culture. The centrifuge 200 and the incubator 300 have lids 202 and 302 provided toward the work chamber 10, respectively. The centrifuge 200 and the incubator 300 are configured such that the interior of the centrifuge 200 and the incubator 300 communicate with the interior of the work chamber 10 by opening the lid 202 and the lid 302, respectively. Therefore, it is possible to carry cells to be worked into the centrifuge 200 or the incubator 300 while maintaining aseptic conditions equivalent to those in the work chamber 10. Further, when the centrifuge 200 and the incubator 300 are connected to the isolator 100, they are electrically connected to the work management unit 30 and can be controlled by the work management unit 30. For example, the work management unit 30 can change conditions such as opening / closing of the door 202 of the centrifuge 200, start / stop of centrifugation, rotation speed, etc., opening / closing of the door 302 of the incubator 300, and changing conditions such as temperature. . Other devices may be attached to the work chamber 10. The isolator 100 is provided with a monitor 40. The monitor 40 is, for example, a CRT display or a liquid crystal monitor. Further, the isolator 100 includes a foot switch 50 as a control switch for controlling the operation of a device such as the centrifuge 200 or the incubator 300.

An example of work management by the work management unit 30 in the isolator 100 will be described below. In the present embodiment, operation control of equipment in work is performed as work management.
FIG. 2 is a control block diagram of the isolator 100 according to the first embodiment. 3 (A) and 3 (B) are schematic views of the work glove 20, FIG. 3 (A) shows the back side of the hand of the work glove 20, and FIG. 3 (B) shows the palm side of the work glove 20. Show. 4 is a diagram illustrating an example of an image displayed on the monitor 40, and FIG. 5 is a schematic diagram illustrating an example of a cursor image movement conversion table. FIG. 6 is a schematic diagram for explaining an example of a device operation instruction method.

  As shown in FIGS. 2 and 3A and 3B, the work glove 20 includes a left hand glove 20L and a right hand glove 20R. The left hand glove 20L is provided with a reader 22a and a wireless tag 24a on the back side of the hand, and a reader 22c and a wireless tag 24c on the palm side, respectively. The right hand glove 20R has a reader 22b and a wireless tag 24b attached to the back of the hand, and a reader 22d and a wireless tag 24d attached to the palm of the hand. Different identification information for instructing the operation of each device is stored in each of the wireless tags 24a to 24d (hereinafter, appropriately referred to as the wireless tag 24). In this case, the device corresponds to the aforementioned operation object, and the identification information for instructing the operation of the device corresponds to information accompanying the operation object.

As illustrated in FIG. 2, the work management unit 30 includes an operation control unit 32 that acquires information read by the reader 22 and controls the operation of the device as described below based on the acquired information. The work management unit 30 has a database 38 as an information storage unit in which a cursor image movement conversion table to be described later is stored. The operation control unit 32 outputs a video signal and displays the image shown in FIG. This image includes a device operation menu executed by the operation control unit 32. The operation menu of the device executed by the operation control unit 32 displayed on the monitor 40 includes, for example, centrifugal start and stop of the centrifuge 200, adjustment of various conditions such as the rotation speed and operating time, or opening and closing of the door of the incubator 300 There are adjustments of various conditions such as temperature, humidity, and CO ₂ concentration. When other devices (device A, device B) are connected to the work room 10, the operation control unit recognizes the connection by receiving signals from these devices, and monitors the operation menu related to these devices 40. To display. The monitor 40 displays a cursor image 42 that can be moved between the operation menus. It should be noted that the image shown in FIG. 4 has a hierarchical structure, with the upper layer on the left side and the lower layer on the right side in the drawing. The operation control unit 32 acquires the identification information transmitted from the reader 22, makes it possible to select an operation menu by moving the cursor image 42 with reference to the cursor image movement conversion table 90 shown in FIG. The operation menu where the image 42 is located is executed. When the cursor image 42 is moved, the operation control unit 32 stores the position to which the cursor image 42 has been moved.

  As shown in FIG. 5, the cursor image movement conversion table 90 is a conversion table in which a combination of identification information stored in the wireless tag 24 and identification information owned by the reader 22 is associated with information related to movement of the cursor image 42. It is. Here, when the reader 22 transmits the identification information stored in the wireless tag 24 to the operation control unit, the reader 22 adds the identification information of the reader 22 to the identification information of the wireless tag 24 and creates the identification information. Is transmitted to the operation control unit. Accordingly, the operation control unit can identify which reader 22 has read which wireless tag 24. Alternatively, the signal from which reader 22 is obtained by changing the terminal for inputting a signal for each of the readers 22a to 22d in the operation control unit, or by changing the frequency of the signal output from the reader 22a to 22d. You may identify. In this embodiment, the association between the identification information and the information related to the movement of the cursor image 42 is as follows. That is, the operation menu at the display position of the cursor image 42 is selected by a combination of the wireless tag 24a and the reader 22b. When the action menu is selected, the cursor image 42 moves to the lower hierarchy when there is a further lower hierarchy action menu in the selected action menu, and the cursor image 42 when the lower hierarchy action menu does not exist. The action according to the action menu at the position is executed. The operation menu at the position of the cursor image 42 is canceled by the combination of the wireless tag 24a and the reader 22d. When the action menu is canceled, the cursor image 42 moves to the upper hierarchy. In the reader 22c and the wireless tag 24b, the cursor image 42 moves to the position of the operation menu displayed on the next level in the same hierarchy. Then, in the reader 22c and the wireless tag 24d, the cursor image 42 moves to the position of the operation menu that is displayed one level below the same hierarchy.

  As shown in FIG. 6, the operator can select the operation menu of the device by moving the position of the cursor image 42 by the combination of the readers 22a to 22d and the wireless tags 24a to 24d. For example, as shown in FIG. 4, the wireless tag 24a provided on the back side of the left hand glove 20L is provided on the palm side of the right hand glove 20R in the state where the cursor image 42 is at the position of the operation menu “setting”. Assume that the data is read by the reader 22d. In this case, the operation menu is canceled, and the cursor image 42 at the “setting” display position moves to the display position of the “centrifuge” corresponding to the upper hierarchy. Then, the operation control unit 32 stores the position of the cursor image 42. For example, it is assumed that the wireless tag 24b provided on the back side of the right hand glove 20R is read by the reader 22c on the palm side of the left hand glove 20L. In this case, the cursor image 42 moves to the display position of “centrifugal stop”, which is an operation menu one level higher in the same hierarchy. Then, the operation control unit 32 stores the position of the cursor image 42.

  When the operator moves the cursor image 42 to the display position of the desired operation menu, the operator reads the wireless tag 24a on the back side of the left hand glove 20L with the reader 22b on the back side of the right hand glove 20R. Can be selected. When the cursor image 42 is selected at the position of the operation menu “setting”, the cursor image 42 moves to the display position of “rotation number”, which is an operation menu in the lower hierarchy. For example, when “centrifuge stop” is selected, the operation control unit 32 performs control so that the centrifuge operation by the centrifuge 200 is stopped. As described above, the operation control unit 32 acquires information transmitted from the reader 22 and controls the operation of the device with reference to the cursor image movement conversion table 90 stored in the database 38. Note that the information regarding the movement of the cursor image 42 and the combination of the reader 22 and the wireless tag 24 can be arbitrarily set.

  FIG. 7 is a flowchart of device operation control by the operation control unit 32.

In the flowchart of FIG. 7, the operation control unit 32 first determines whether information has been transmitted from the reader 22 (step S <b> 701: hereinafter abbreviated as S <b> 701, and other steps are also the same). When there is no information transmission from the reader 22 (S701_No), the determination of the presence / absence of information transmission from the reader 22 is repeated. When information is transmitted from the reader 22 (Yes in S701), the control operation designated by the operator is confirmed with reference to the cursor image movement conversion table 90 stored in the database 38 (S702). Then, it is determined whether the operator's instruction is to select an operation menu (S703). If the operation menu is selected (Yes in S703), it is determined whether there is a lower layer in the operation menu where the cursor image 42 is currently located (S704). If there is no lower hierarchy in the selected action menu (No in S704), it is determined whether the selected action menu can be executed (S705). Here, for example, when the device that is the target of the operation menu is connected to the isolator 100, or the selected operation menu is “centrifugal start”, the door 202 of the centrifuge 200 is closed. It is judged whether it is. If the selected operation menu can be executed (Yes in S705), the operation corresponding to the operation menu is executed (S706). On the other hand, when it is impossible to execute the selected operation menu (No in S705), the operation control unit 32 warns the operator by displaying a warning message on the monitor 40 (S707). When the operator's instruction is not selection of the action menu (No in S703), or when the selected action menu has a lower layer (Yes in S704), the cursor image referring to the cursor image movement conversion table 90 The movement control of 42 is executed (S708).
As described above, the operation control unit 32 controls the operation of the device.

  In FIG. 4, a star (★) is displayed. When selecting and executing the control contents with the star mark, it is necessary to acquire a signal permitting this operation transmitted from the foot switch 50 in addition to the signal from the reader 22. Yes. As described above, for operations that require a high degree of safety, such as the start of the centrifuge operation of the centrifuge 200, for example, an operation instruction by the combination of the reader 22 and the wireless tag 24 and an operation instruction by the foot switch 50 are two. One instruction is needed. Thereby, the safety | security of the isolator 100 can be improved.

  8 and 9 are schematic diagrams for explaining another example of the device operation instruction method, and FIG. 10 is a schematic diagram showing another example of the cursor image movement conversion table. FIG. 11 is a schematic diagram illustrating an example of a device operation conversion table.

  As shown in FIG. 8, the wireless tag 24 may be provided in the work chamber 10. Alternatively, the wireless tag 24 may be provided in a device, for example, a lid in contact with the work chamber 10 of the device or a content chamber. Furthermore, as shown in FIG. 9, the wireless tag 24 may be arranged, for example, on the arm of the left hand glove 20L. The readers 22a to 22d that read the identification information stored in the wireless tag 24 may not be identified. In this case, as shown in FIG. 10, a cursor image movement conversion table 91 in which identification information stored in each of the wireless tags 24a to 24d is associated with information related to movement of different cursor images is stored in the database. . In the cursor image movement conversion table 91, the wireless tag 24a selects an operation menu, the wireless tag 24b cancels the operation menu, the wireless tag 24c moves up one level in the wireless tag 24d, Are associated with movement down one level in the same hierarchy.

  Furthermore, a device operation conversion table 92 as shown in FIG. 11 that associates the identification information stored in the wireless tag 24 with information related to device operation may be stored in the database. In the device operation conversion table 92, the wireless tag 24a is associated with opening / closing of the door 202 of the centrifuge 200, and the wireless tag 24b is associated with centrifuge start of the centrifuge 200. The wireless tag 24c is associated with the centrifugal stop of the centrifuge 200, and the wireless tag 24d is associated with opening / closing of the door 302 of the incubator 300. In this case, the operation of the device can be controlled without moving the cursor image 42 on the operation menu image displayed on the monitor 40 and selecting the operation menu. The wireless tag 24 may store the identification information and information related to the operation of the device in association with each other. In this case, the operation control unit 32 can control the operation of the device without referring to the conversion table stored in the database. In addition, when associating the identification information with the information on the operation of the device, the operator visually recognizes the wireless tag 24 by displaying some information about the operation of the device associated with the identification information. Can be confirmed.

  When the operations according to the configuration described above are summarized, in the isolator 100 of the first embodiment, the reader 22 provided in the work chamber 10 receives the information from the wireless tag 24 in which the identification information for instructing the operation of the device is stored. I'm reading. Then, the operation control unit acquires information read by the reader 22 and controls the operation of the device. Therefore, when operating devices such as the centrifuge 200 and the incubator 300, it is not necessary to remove the hand from the work glove 20, and the operator can smoothly operate the device with the hand inserted into the work glove 20. It can be performed and the burden on the operator can be reduced. Therefore, the work efficiency in the work with the isolator 100 can be improved and the occurrence of human error can be suppressed.

  Further, since the operation control unit 32 displays the operation menu of the device on the monitor 40 and the operator can instruct the operation of the device while checking the image displayed on the monitor 40, the workability of the isolator 100 is improved. Will improve. Further, for example, a control signal from the foot switch 50 is also required for an instruction of a specific operation such as an operation with a high necessity for safety confirmation or an operation related to a process important for work. Increases safety and work reliability.

(Embodiment 2)
In the second embodiment, the information stored in the wireless tag 24 provided in the equipment used in the work room 10 is acquired, and the history of work performed in the work room 10 is created, or by the operator The point which judges the correctness of the work performed differs from Embodiment 1. About the structure and operation | movement similar to Embodiment 1 other than that, while using the same drawing, description is abbreviate | omitted suitably.

FIG. 12 is a schematic diagram illustrating the configuration of the isolator 100 according to the second embodiment. FIG. 13 is a control block diagram of the isolator 100 according to the second embodiment.
As shown in FIGS. 12 and 13, in the isolator 100 according to the second embodiment, the work management unit 30 acquires information read by the reader 22 and performs work performed in the work room 10 based on the acquired information. The history creation unit 34 sequentially creates and stores the history. The work management unit 30 compares the information read by the reader 22 with the information on the work process to be performed next out of the work process information stored in the database 38 in advance, and is performed by the worker. It has a process monitoring unit 36 for judging whether the work is correct or incorrect. Further, the isolator 100 is provided with a camera 60 as an imaging means for imaging the inside of the work chamber 10. Imaging in the work room 10 by the camera 60 is controlled by the history creation unit 34. Regarding the reader 22, a reader 22c is provided on the palm side of the left hand glove 20L, and 22d is provided on the palm side of the right hand glove 20R.

FIGS. 14A and 14B are diagrams illustrating a target to which the wireless tag 24 is attached and a state in which the information stored in the wireless tag 24 is read by the reader 22. FIG. 15 is a schematic diagram illustrating an example of the operation target information conversion table, and FIG. 16 is a diagram illustrating an example of a work history.
As shown in FIG. 14A, the wireless tag 24 is attached to each equipment 70 used in the work chamber 10. Examples of the equipment 70 include a cell culture flask 70a, a culture solution bottle 70b, a reagent tube 70c, and a pipetter 70d. The wireless tag 24 stores identification information of the attached equipment 70. The history creation unit 34 acquires information stored in the wireless tag 24 read by the reader 22 and sequentially creates and stores a history of work performed in the work room 10 based on the acquired information. In this case, the instrument 70 corresponds to the operation target, and the identification information of the instrument corresponds to information accompanying the operation target. Further, the wireless tag 24 is attached to a gripping portion of the equipment 70, and therefore, when the operator grips the equipment 70 via the work glove 20, as shown in FIG. Information stored in the wireless tag 24 is read by a reader 22 provided in the globe 20.

  The wireless tag 24 stores unique identification information for each attached device 70, and the database 38 stores the identification information stored in the wireless tag 24 and information about the device 70 as shown in FIG. Is stored in the operation target information conversion table 93. The history creation unit 34 acquires the identification information of the wireless tag 24 read by the reader 22, converts the identification information acquired with reference to the operation target information conversion table 93 into information about the equipment 70, and creates a work history. ing. The information related to the equipment 70 includes information to be read, for example, information that the cell culture flask 70a, the culture solution bottle 70b, the reagent tube 70c, and the pipetter 70d are included. Further, as the information on the equipment 70, detailed information on the contents of the equipment 70, for example, the types of cells in the cell culture flask 70a, the components of the culture solution in the culture solution bottle 70b, the types of reagents in the reagent tube 70c, etc. Information is included. The wireless tag 24 may store the identification information of the equipment 70 and the information related to the equipment 70 in association with each other. In this case, the history creation unit 34 can create a work history without referring to the conversion table stored in the database.

In addition, a wireless tag (not shown) that stores unique identification information for each device such as the centrifuge 200 and the incubator 300 is attached in the work chamber 10. In the operation target information conversion table 93, the identification information and the device Is associated with information about. The wireless tag 24 may be attached to a device lid, for example. If the work in the work room 10 involves an operation of the device, the reader 22 reads the identification information stored in the wireless tag 24 and transmits it to the history creation unit 34. The history creation unit 34 The identification information acquired with reference to the target information conversion table 93 is converted into information about the device, and a work history is created. In the case where the operation control unit 32 acquires information read by the reader 22 and controls the operation of the device as in the first embodiment, the operation target information conversion table 93 is used to instruct the operation of the device. The identification information is associated with information about the device. Thereby, it is possible to create a work history together with the operation control of the device. The information on the equipment includes information on the type of equipment, for example, information on the centrifuge 200 and the incubator 300, and information on the setting state of the equipment, such as the centrifugal speed of the centrifuge 200 and the CO ₂ concentration of the incubator 300. Contains information.

  In addition, the history creation unit 34 images the inside of the work chamber 10 with the camera 60 at a predetermined timing based on the timing at which the information read by the reader 22 is acquired, for example, at a timing at which a signal from the reader 22 is received. Then, the history creation unit 34 acquires an image captured by the camera 60 and stores it in association with the created history. Imaging with the camera 60 may be performed continuously at predetermined intervals. The image captured by the camera 60 may be a still image or a moving image. When the camera 60 continuously captures images at a predetermined interval, the history creation unit 34 can store an image within a predetermined time range in association with the history on the basis of the timing at which the signal from the reader 22 is received.

  As shown in FIG. 16, the work history includes, for example, the date, time, work content, operation object read by the reader 22, detailed information related to the operation object, and the history creation unit 34 of the reader 22. The image at the timing of receiving the signal from is included. In addition to this, it is also possible to incorporate the worker's identification information and the like into the work history by controlling the worker to register his / her own identification information.

Next, work process management control for determining whether the work performed by the worker is correct or incorrect will be described. FIG. 17 is a flowchart of work process management control by the process monitoring unit 36.
The database 38 can store in advance work process information of work performed in the work room 10. The work process information is, for example, in the form of a conversion table in which the identification information of the equipment 70 or device used in each process is associated with the information related to the equipment 70 or the equipment and listed in the order of the processes. Before starting the work, the worker stores work process information of work to be performed in the database in advance. The process monitoring unit 36 compares the information read by the reader 22 with the information on the work process to be performed next out of the work process information stored in the database 38 in advance, and corrects the work performed by the worker. Judging.

  In the flowchart of FIG. 17, upon receiving a work designation from the worker (S1701), the process monitoring unit 36 reads work process information on the designated work from the database 38 (S1702). Subsequently, work process information relating to the first process of the designated work is specified (S1703). Then, it is determined whether information has been transmitted from the reader 22 (step S1704). When there is no information transmission from the reader 22 (No in S1704), the determination of the presence / absence of information transmission from the reader 22 is repeated. When information is transmitted from the reader 22 (Yes in S1704), it is determined whether the information transmitted from the reader 22 matches the work process information related to the specified work process (S1705). If the information matches (Yes in S1705), it is determined whether the identified work process is the last process (S1706). If the identified work process is not the last process (No in S1706), work process information relating to the next process is identified (S1707), and it is determined whether or not information is transmitted from the reader 22 (S1704). If the identified work process is the last process (Yes in S1706), the process monitoring unit 36 ends the work process management control. When the information transmitted from the reader 22 does not match the work process information related to the specified work process (No in S1705), an alarm sound is generated by the alarm 80, and the work is incorrect for the worker. Is notified (S1708). The warning to the worker may be performed by displaying a warning message on the monitor 40, for example.

  Further, the process monitoring unit 36 may display the work process information stored in the database 38 on the monitor 40 when performing the work process management control. According to this, the worker can confirm the work process with the hand inserted into the work glove 20.

  In summary, the isolator 100 according to the second embodiment reads the identification information of the equipment 70 stored in the wireless tag 24 attached to the equipment 70 by the reader 22 provided in the work chamber 10. ing. Then, the history creation unit 34 acquires information read by the reader 22 and creates a work history based on the information. Therefore, the work history can be created in a state where the operator inserts his / her hand into the work glove 20. Therefore, the work efficiency in the work with the isolator 100 is improved.

  The reader 22 is provided in the work glove 20 in the work chamber 10, and information stored in the wireless tag 24 by the reader 22 when the operator grips the equipment 70 through the work glove 20 is stored. Read. Therefore, an extra operation for reading the wireless tag 24 is not required, and the reading of the wireless tag 24 is not forgotten. In addition, since the history creation unit 34 obtains information stored in the wireless tag 24 and creates a work history, an accurate work history can be created. Furthermore, since an image is incorporated in the work history in correspondence with the information acquired by the history creation unit 34, a more accurate and reliable work history can be created, and the occurrence of human errors can be suppressed. it can. In addition, the reliability of experiments, research, and treatment using the cells processed in the operation of the isolator 100 is improved.

  Furthermore, the information read by the reader 22 is compared with the work process information stored in advance to determine whether the work performed by the worker is correct or incorrect. In addition, work process information is displayed on the monitor 40. Therefore, it is not necessary for the operator to remove his / her hand from the work glove 20 in order to confirm the work process, and work efficiency in work with the isolator 100 is improved. Further, when there is an error in the work process, the operator is notified in real time, so that the occurrence of human error can be suppressed, and the work reliability in the isolator 100 is improved.

  The present invention is not limited to the above-described embodiments, and various modifications such as design changes can be added based on the knowledge of those skilled in the art. Embodiments to which such modifications are added Can also be included in the scope of the present invention.

  For example, in the first embodiment, the operation of the device is controlled using the wireless tag 24, and in the second embodiment, a work history is created using the wireless tag 24, and the correctness of the work process is determined. May be implemented.

FIG. 18 is a diagram illustrating an example of an image displayed on the monitor 40 when the operation control of the device, the creation of the work history, and the correctness / incorrectness of the work process are performed together.
As shown in FIG. 18, the operation menu of the device executed by the operation control unit 32 as the device operation mode is displayed on the monitor 40, and the work process information stored in advance as the work process selection mode is displayed. Then, as in the first embodiment, the cursor image 42 is operated, and it becomes possible to select an operation of the device and a work process for which work process information is to be displayed. In addition, the history creation unit 34 can create a work history using the identification information of the wireless tag acquired for controlling the operation of the device or determining whether the work process is correct or incorrect. When the process monitoring unit 36 determines that the operator's work is wrong, the process monitoring unit 36 transmits a control signal to the operation control unit 32. When the operation control unit 32 receives this signal from the process monitoring unit 36, the operation of the device is performed. You may control to prohibit.

1 is a schematic diagram illustrating a configuration of an isolator according to a first embodiment. It is a control block diagram of an isolator. FIGS. 3A and 3B are schematic views of a working glove. It is a figure which shows an example of the image displayed on a monitor. It is the schematic which shows an example of a cursor image movement conversion table. It is a schematic diagram for demonstrating an example of the operation instruction | indication method of an apparatus. It is the operation | movement control flowchart of an apparatus by an operation control part. It is a schematic diagram for demonstrating the other example of the operation instruction | indication method of an apparatus. It is a schematic diagram for demonstrating the other example of the operation instruction | indication method of an apparatus. It is the schematic which shows the other example of a cursor image movement conversion table. It is the schematic which shows an example of an apparatus operation | movement conversion table. FIG. 5 is a schematic diagram illustrating a configuration of an isolator according to a second embodiment. It is a control block diagram of an isolator. 14A and 14B are diagrams illustrating a target to which a wireless tag is attached and a state in which information stored in the wireless tag is read by a reader. It is the schematic which shows an example of the operation target information conversion table. It is a figure which shows an example of a work history. It is a work process management control flowchart by a process monitoring part. It is a figure which shows an example of the image displayed on a monitor in the case of implementing together operation control of an apparatus, preparation of work history, and judgment of the right / wrong of a work process.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 10 Work room, 12 Front door, 20 Work glove, 20L Left hand glove, 20R Right hand glove, 22, 22a, 22b, 22c, 22d Reader, 24, 24a, 24b, 24c, 24d Wireless tag, 30 Work management part , 32 operation control unit, 34 history creation unit, 36 process monitoring unit, 38 database, 40 monitor, 42 cursor image, 50 foot switch, 60 camera, 100 isolator, 200 centrifuge, 300 incubator.

Claims (10)

A working room for performing work on biological materials;
A reader that is provided in the work chamber and reads the information from a wireless tag in which information associated with an operation target in the work is stored;
A work management unit that acquires the information read by the reader and manages the work;
An isolator comprising: A working glove provided on the front side of the working chamber toward the working chamber, further comprising a work glove for performing work in the working chamber;
The isolator according to claim 1, wherein the reader is provided in the work glove. The operation object is attached to the work room, and includes equipment used for the work,
The wireless tag is provided in at least one location of the work chamber, the device or the work glove,
The information includes identification information for instructing the operation of the device,
The isolator according to claim 2, wherein the work management unit includes an operation control unit that acquires information read by the reader and controls operation of the device based on the acquired information. A control switch for controlling the operation of the device;
The operation control unit controls the operation of the device when acquiring information read by the reader and a signal transmitted from the control switch permitting the operation of the device specified by the information. The isolator according to claim 3. A monitor for displaying an operation menu of the device to an operator;
The operation control unit displays an operation menu of the device on the monitor, enables selection of the operation menu based on information read by the reader, and executes the selected operation. The isolator according to claim 3 or 4. The operation object includes equipment used in the work chamber,
The wireless tag is provided for each device,
The information includes identification information of the equipment,
The work management unit includes a history creation unit that obtains information read by the reader and sequentially creates and stores a history of work performed in the work room based on the obtained information. The isolator according to any one of claims 1 to 5. It further comprises imaging means for imaging the work chamber,
The history creation unit obtains an image captured by the imaging unit at a predetermined timing based on a timing at which information read by the reader is acquired, and stores the image in association with the created history. The isolator according to claim 6.   The isolator according to claim 6 or 7, wherein the information is read by the reader when an operator grips the device through the work glove. An information storage unit for storing work process information of the work;
The work management unit compares the information read by the reader with the information on the work process to be performed next out of the work process information stored in advance in the information storage unit, and is performed by an operator. The isolator according to any one of claims 1 to 8, further comprising a process monitoring unit that determines whether the work is correct or incorrect. A monitor for displaying the work process information to an operator;
The isolator according to claim 9, wherein the process monitoring unit displays the work process information stored in the information storage unit on the monitor.

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