JP2009178531A - Carbohydrate microneedle, and method and device for manufacturing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To solve problems of a conventional carbohydrate microneedle wherein the needle part is broken in a part around a weak bonded part between the needle part and a base plate part and the needle part cannot stick in the skin when the needle part is inserted into the skin because the needle part and the base plate part are made of different materials and the bond between the needle part and the base plate part is weak, and wherein the practical utility is extremely impaired because a medicament, etc. is mounted on the upper surface of the needle part only, and as a result, the size of the medicament etc. is limited and the dose of the medicament to the skin is limited, or the like. <P>SOLUTION: The carbohydrate microneedle is composed of one or a plurality of carbohydrate microneedles disposed and integrated in the shape of a comb on a side face of a microneedle attaching margin. The attaching margin is welded to a side end or biting part on the upper surface of the base plate made of a different material. As a result, the strength in the vicinity of the root of the needle part is high, so that the effect of easy sticking in the skin, and the effect of mounting a larger quantity of medicaments on the upper surface of the needle part and the upper surface of the attaching margin can be provided. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention is a transdermal dosage / administration in which a pharmaceutical agent, nutritional supplement, cosmetic material, biological material, etc. is inserted into the skin with a fine sugar needle for the purpose of treatment and improvement of the skin, and further biomodification, etc. The present invention also relates to a skin modification technique in which a cosmetic material is inserted into a human skin for beauty by inserting a fine sugar needle.

  Conventionally, research and development of microneedles has been actively conducted for the purpose of transdermal administration, and most of them used industrial materials such as metals and plastics as the material of microneedles. Therefore, the fine needles of carbohydrate materials that are high and adaptable to living bodies, that is, fine sugar needles are being developed.

  As a method for retaining a drug or the like on the fine sugar needle, a method of mixing the drug or the like with a sugar as a material of the fine needle and a method of attaching the drug or the like to the surface of the fine sugar needle have been adopted. However, it has been difficult to ensure a sufficient dose of the pharmaceutical agent by the above-described mixing and adhesion method using a single fine needle.

  Therefore, in order to secure a sufficient amount of pharmaceutical agent, the above-mentioned fine needles mixed and adhering to medicinal materials are micropile-shaped microneedles, sword-shaped microneedles, and comb-shaped with fine needles arranged in a row Fine needles have been adopted, and an injection molding method has been applied as a manufacturing method thereof. However, there has been a waste in that a drug or the like is contained in the substrate in addition to the fine needles, which is a problem in practical use.

Examples of the development of the above-described micropile skin microneedles include functional micropile, which is a fine needle assembly mainly composed of carbohydrate maltose, and a method for producing the same (for example, see Patent Document 1). This greatly improves the convenience and safety for skin function regeneration in a painless state when imparting a function to the skin surface or the skin stratum corneum.
JP 2003-238347 A

  In a conventional fine sugar needle in which a drug or the like is mixed, the substrate on which the needle is provided is also sugar and linked to the needle, so that the drug or the like enters the substrate wastefully. Therefore, in order to separate the needle and the substrate, it is possible to use a material different from carbohydrates for the substrate, and to prevent drugs and the like from being mixed into the substrate unnecessarily, but in this case, the adhesion between the needle part and the substrate is fragile. Thus, when the needle part is inserted into the skin, the problem is that the needle part breaks in the vicinity of the fragile adhesion site and does not pierce the skin, and the practicality is extremely reduced. For this reason, even the comb-shaped fine saccharide needles arranged in a row as the most practical shape are so brittle that they are broken when inserted into the skin, and the practicality cannot be endured. Incidentally, the external shape and cross section of a conventional comb-shaped fine sugar needle are shown in FIGS. 1 and 2, but here the material of the fine sugar needle 1 (sugar) and the material of the substrate 2 are different, and the fine sugar is different. The needle 1 and the substrate 2 are in an adhesive state, and the adhesion part 3 becomes brittle, and there is a drawback that the fine needle is very easily broken in the vicinity of the adhesion part 3 at the time of skin insertion.

  Further, in the conventional fine sugar needle, when the fine sugar needle is manufactured by dividing the fine needle portion and the substrate portion, there is a step between the upper surface of the fine needle and the upper surface of the substrate. However, since a sufficiently smooth surface cannot be formed, the strength of the root of the fine needle is lowered, and the fine needle is very easy to break in the vicinity of the fragile root, and the problem is that it does not pierce the skin.

  Conventionally, in order to insert a fine sugar needle for cosmetic purposes only in the skin stratum corneum, it has been necessary to make the length of the fine needle sufficiently small to be equal to the thickness of the stratum corneum. However, with such a fine needle, since the volume of the portion that can be inserted into the stratum corneum of the skin is too small, a sufficient dose cannot be ensured only with the drug mixed in the needle portion made of sugar. Therefore, in order to solve this problem, a drug or cosmetic material mixed with fine needles, and further a drug or cosmetic material fragmented (chip), which is mounted or encapsulated in a fine needle has been developed. However, since the fine needles are very small, the above-mentioned drug chips and cosmetic material chips are also miniaturized, and the dose of drugs and the like to the skin is limited accordingly. Incidentally, FIG. 3 shows a cross section of a conventional fine sugar needle loaded with a drug chip. Here, since the drug chip 4 is loaded only on the upper surface of the fine sugar needle 1, the size of the drug chip 4 is limited. Accordingly, the dose of the drug to the skin is restricted accordingly.

  Furthermore, when molding fine needles with materials that require heating and dissolution, such as carbohydrates, there are drugs that cannot withstand the heating during molding depending on the drugs and cosmetics to be mixed, such as drugs. The problem was that the types were limited.

As a means for solving the above-mentioned problems, the present invention provides:
(1) A fine needle made of a saccharide having a perpendicular length from the needle tip to the needle bottom of 100 μm to 2 mm, a needle bottom width of 20 μm to 1 mm, and a needle bottom length of 20 μm to 1 mm is Is a structure in which one or a plurality of combs are arranged on the side surface of the sugar fine needle mounting allowance welded to the upper surface side end of a substrate made of a different material. As well as
(2) A fine needle composed of a saccharide having a perpendicular length from the needle tip portion to the needle bottom portion of 100 μm to 2 mm, a needle bottom portion lateral width of 20 μm to 1 mm, and a needle bottom portion vertical width of 20 μm to 1 mm, Are arranged on the side surface of the sugar fine needle attachment allowance welded to the upper bite portion of the substrate made of a different material, and arranged in one or a plurality of comb shapes, and the fine needle upper surface and the fine needle attachment allowance upper surface And a fine sugar needle characterized by having a continuously smooth structure, and
(3) The fine sugar needle according to claim 2, wherein the fine needle mounting allowance upper surface and the substrate upper surface have a smooth structure continuously, and
(4) The fine sugar needle according to (2) or (3), wherein the fine sugar needle has a sword mountain-like structure in which a plurality of the substrates are stacked so that the fine sugar needle points in the same direction. Quality needles, and
(5) The fine sugar needle according to any one of (1) to (4), wherein the substrate comprises a plurality of layers, and
(6) Any one of (1) to (5) above, wherein the material of the substrate is one or more selected from plastic, wood, metal, paper, polysaccharide material, gelatin and protein solids Fine sugar needles, and
(7) The fine sugar needle according to any one of (1) to (5), wherein the sugar is maltose, and the material of the substrate is paper, and
(8) The above (1) to (7), wherein glucose is coated on both upper surfaces of the fine needle mounting allowance surface that forms a continuous smooth surface with the upper surface of the fine needle, and a drug is mounted on the glucose-coated surface. ) Any fine sugar needle, and
(9) The fine sugar needle according to any one of (1) to (7), wherein a drug is contained in the fine needle, and
(10) 1 or 2 wherein the drug is selected from sodium ascorbate, magnesium ascorbate, hyaluronic acid, collagen, human IgG, human IgM, antibody drug, nucleic acid drug, dye, vitamin A, vitamins, insulin, hormone The fine sugar needle according to (8) or (9) above, and
(11) From (1) to (1), wherein glucose is coated on both upper surfaces of the fine needle mounting allowance surface forming a continuous smooth surface with the fine needle upper surface, and a biological material is mounted on the glucose coated surface. 7) any fine sugar needle, and
(12) The fine sugar needle according to any one of (1) to (7), wherein a biological material is encapsulated in the fine needle, and
(13) The biological material is one or more selected from DNA, amino acid, protein, human IgG antibody, vaccine, intracellular microbody, cell, and microorganism, (11) or (12) ) Fine sugar needles, and
(14) In a method of independently using a mold dedicated to a fine needle separated from a substrate when producing a fine sugar needle, the upper surface of the fine needle after the mold separation and the upper end side of the substrate upper surface or the upper surface of the substrate A method of pressing and flattening the upper surface of the fine needle, the upper surface of the fine needle attachment, and the upper surface of the substrate is used so that the upper surface of the fine needle attachment margin provided in the biting portion and the upper surface of the substrate are smooth. A method for producing a fine saccharide needle, and
(15) In a method of independently using a mold dedicated to a fine needle separated from a substrate when manufacturing a fine sugar needle, the upper surface of the fine needle after separation of the mold and the upper surface side end of the substrate or the upper surface of the substrate A method for pressurizing and flattening the upper surface of the fine needle, the upper surface of the fine needle attachment, and the upper surface of the substrate so that the upper surface of the fine needle attachment margin provided on the biting portion and the upper surface of the substrate are smooth surfaces. Fine sugar needle manufacturing apparatus characterized by having a pressurizing mechanism, and
(16) In a method of independently using a mold dedicated to a fine needle separated from a substrate when manufacturing a fine sugar needle, the upper surface of the fine needle after separation of the mold and the upper end of the substrate upper surface or the upper surface of the substrate A method of sweeping and flattening the upper surface of the fine needle, the upper surface of the fine needle attachment, and the upper surface of the substrate is used so that the upper surface of the fine needle attachment margin provided on the biting portion and the upper surface of the substrate are smooth. A method for producing a fine saccharide needle, and
(17) In a method of independently using a mold dedicated to a fine needle separated from a substrate when manufacturing a fine sugar needle, the upper surface of the fine needle after the mold separation and the upper end of the substrate upper surface or the upper surface of the substrate A method for sweeping and flattening the upper surface of the fine needle, the upper surface of the fine needle attachment, and the upper surface of the substrate so as to make the upper surface of the fine needle attachment margin provided in the biting portion and the upper surface of the substrate smooth. Fine sugar needle manufacturing apparatus characterized by having a sweep mechanism, and
(18) In a method of independently using a mold dedicated to a fine needle separated from a substrate when manufacturing a fine sugar needle, the upper surface of the fine needle after the mold separation and the upper end of the substrate upper surface or the upper surface of the substrate The upper surface of the fine needle, the upper surface of the fine needle attachment, and the upper surface of the substrate are flattened by applying pressure to the upper surface of the fine needle, the upper surface of the fine needle, and the upper surface of the substrate so as to make the upper surface of the fine needle attachment surface and the upper surface of the substrate smooth. A method for producing a fine sugar needle characterized by using the method, and
(19) In a method of independently using a mold dedicated to a fine needle separated from a substrate when manufacturing a fine sugar needle, the upper surface of the fine needle after separation of the mold, the upper surface side end of the substrate, or the upper surface of the substrate The upper surface of the fine needle, the upper surface of the fine needle attachment, and the upper surface of the substrate are flattened by applying pressure to the upper surface of the fine needle, the upper surface of the fine needle, and the upper surface of the substrate so as to make the upper surface of the fine needle attachment surface and the upper surface of the substrate smooth. A fine sugar needle manufacturing apparatus characterized by having a rotating roller for use in the method, and
(20) In a method of independently using a mold dedicated to a fine needle separated from a substrate when manufacturing a fine sugar needle, the upper surface of the fine needle after the mold separation and the upper surface side end of the substrate or the upper surface of the substrate The upper surface of the fine needle, the upper surface of the fine needle, and the upper surface of the substrate are swept and flattened by a movable sheet so that the upper surface of the fine needle mounting allowance provided on the biting portion and the upper surface of the substrate are smooth. A method for producing a fine sugar needle characterized by using the method, and
(21) In a method of independently using a mold dedicated to a fine needle separated from a substrate when producing a fine sugar needle, the upper surface of the fine needle after the mold separation and the upper end of the substrate upper surface or the upper surface of the substrate The upper surface of the fine needle, the upper surface of the fine needle, and the upper surface of the substrate are swept and flattened by a movable sheet so that the upper surface of the fine needle mounting allowance provided on the biting portion and the upper surface of the substrate are smooth. An apparatus for producing a fine carbohydrate needle, characterized by having a movable sheet for use in the method.

  In the fine sugar needle of the present invention, one fine needle is arranged on the side surface of the fine needle mounting allowance made of the same material as the fine needle, or a plurality of the fine needles are arranged in a comb shape, By adopting a structure in which the fine needle mounting allowance is welded to the upper surface side end portion of the substrate made of a material different from the sugar of the fine needle, the fine needle and the fine needle mounting allowance by this welding are made of the same material sugar. Due to the integral structure, when the fine needle is inserted into the skin, the fine needle is difficult to break and can be easily pierced into the skin. FIG. 4 shows an outline of an example of a fine sugar needle having an attachment allowance by welding. Here, the fine needle 5 and the fine needle attachment allowance 6 welded to the upper surface side end of the substrate 2 have an integrated structure. Thus, when the fine needle is inserted into the skin, the fine needle is difficult to break and easily pierces the skin. After that, the fine needle stuck in the skin is easily broken in the skin, and the fine needle remaining in the skin itself is dissolved, so that it is safe. Incidentally, FIG. 4 shows a case where the upper surface of the fine needle 5 and the upper surface of the fine needle mounting allowance 6 are a continuous smooth surface. A large amount of drug, cosmetic material, and biological substance are placed on these wide smooth surfaces. It is possible to mount on. FIG. 5 shows another example of the fine sugar needle. Here, the upper surface of the fine needle 5 and the upper surface of the fine needle mounting allowance 6 do not form a continuous smooth surface. Although it is difficult to mount a large amount of drugs, nutritional supplements, cosmetics, and biological substances, it is possible to contain drugs and the like inside the fine needles even in this case.

  In the fine saccharide needle of the present invention, one fine needle is arranged on the side surface of the fine needle attachment allowance made of the same material as the fine needle, or a plurality of the fine needles are arranged in a comb shape, The fine needle mounting allowance is welded to the top biting portion of the substrate made of a material different from the sugar of the fine needle, and the fine needle upper surface and the fine needle attaching allowance upper surface are continuously smoothed to achieve a fine structure. The fine needle mounting allowance by the needle and bite becomes an integral structure made of the same material sugar, making it possible to make the fine needle difficult to break. As a result, when the fine needle is inserted into the skin, the fine needle is difficult to break and can be easily pierced into the skin. FIG. 6 and FIG. 7 show an outer shape and a cross section of an example of a fine sugar needle having an attachment allowance due to this biting, and this figure shows a comb-shaped fine sugar needle having a common bite allowance. Here, the fine needle 5 and the fine needle mounting allowance 7 welded to the top biting portion of the substrate 2 have an integral structure, and when the fine needle 5 is inserted into the skin, the fine needle 5 is difficult to break and into the skin. It becomes easy to stick. After that, the fine needle stuck in the skin is easily broken in the skin, and the fine needle remaining in the skin itself is dissolved, so that it is safe. In the present invention, the fine needle portion means a portion of a fine needle surrounded by a wavy circle shown in FIG. 6, and the fine sugar needle of the present invention means the fine needle portion and the fine needle portion. It consists of a needle mounting allowance part and a substrate part. The outline of an example of a fine sugar needle that does not have a common bite allowance is shown in FIGS. 8 and 9, but here, the upper surface of the fine needle 5 and the upper surface of the fine needle mounting allowance 7 are a smooth surface. Therefore, it is possible to mount a large amount of drugs, cosmetics, and biological substances on these wide smooth surfaces. In addition, cross sections of various examples of fine sugar needles having different shapes of bite allowances are shown in FIGS. 10, 11, 12, and 13. These various types of fine sugar needles are used in accordance with the purpose such as maintaining the strength near the root of the fine needle, the vicinity of the portion where the fine needle is attached and the substrate, or reducing the manufacturing cost. It is possible to use different shapes. That is, for example, in the case of the step-shaped fine needle mounting allowance as shown in FIG. 13, the contact area with the substrate is further increased as compared with the case shown in FIG. Become.

  Further, in the fine sugar needle of the present invention, if the fine attachment allowance upper surface and the substrate upper surface are both flattened and smoothly connected so as not to be stepped, the fine needle and the attachment allowance are integrated and further strengthened. Thus, cracks hardly occur and the fine needles do not break during skin insertion, making it easier to pierce the skin.

In the fine sugar needle of the present invention, the outer shape of a fine sugar needle having a sword-like structure in which a plurality of substrates are stacked so that the needle portion of the fine sugar needle points in the same direction is shown in FIG. In the drawing, three substrates are stacked. As a result, the number of fine needles that pierce the skin increases, so the number of chips such as drugs mounted on the fine saccharide needles also increases, and the weight of drugs etc. contained in the fine saccharide needles also increases. A large amount of drugs, nutritional supplements, cosmetics, and biological substances can be administered to the skin.
FIG. 15 shows the outer shape of a fine carbohydrate needle in which the substrate itself is composed of a plurality of layers. By adopting a substrate composed of a plurality of layers, a thin carbohydrate can be formed into a plurality of layers, thereby forming a fine carbohydrate. The needle can be made stronger, and the thickness of the substrate can be adjusted using existing plastic, wood, metal, paper, polysaccharides, gelatin, and protein solids by using multiple layers. It becomes possible.

  The fine sugar needle of the present invention has a structure in which a drug, a cosmetic material or the like is made into a chip and adhered by glucose on the fine needle upper surface and the fine needle mounting allowance upper surface, and the fine needle upper surface and the substrate upper surface are connected smoothly. For example, the chip can be covered and extended up to the upper surface of the substrate, so that the dose of a drug or the like can be expanded. At the same time, since it becomes easy to mount the medicine or the cosmetic material after the molding by heating and melting, it becomes possible to avoid the heat deterioration of the medicine or the like. FIGS. 16 and 17 show cross-sections of an example of a fine sugar needle loaded with this medicine, etc. FIG. 16 shows a fine sugar needle having a fine needle mounting allowance welded to the upper surface side end portion, and FIG. The fine saccharide needle | hook which has the fine needle attachment allowance welded to the board | substrate upper surface biting part is shown.

  In the fine sugar needle of the present invention, as a manufacturing method for making the upper surface of the fine needle, the upper surface of the fine needle mounting allowance, and the upper surface of the substrate coincide with each other without any step, the upper surface of the fine needle and the upper surface of the fine needle attachment allowance In order to flatten the upper surfaces of the substrates by making them coincide with each other without any level difference, it has become possible to achieve them by performing various pressurizations and sweeps on the upper surfaces.

  In the pressurization for flattening in the fine sugar needle of the present invention, a method of pressurizing the upper surface of the fine needle, the upper surface of the fine needle attachment and the upper surface of the substrate simultaneously with a cobblestone or a pressure plate, etc. By using these methods, the above-described planarization is possible. In addition, the above sweeping for flattening includes a method of moving the surface from the top surface of the fine needle to the top surface of the substrate or in the opposite direction by rubbing the surface with a sweeping spatula, the top surface of the fine needle to the top surface of the substrate, or the reverse direction. By using one of the methods such as a method of moving while pressing with a rotating roller, a method of sweeping the surface of the movable sheet from the upper surface of the substrate to the upper surface of the fine needles, and the like, the above flattening can be performed. . Furthermore, by using a fine needle manufacturing apparatus having a pressurizing mechanism and a sweeping mechanism for use in the above-described flattening method, it is possible to manufacture a fine sugar needle having the above flattened structure. . Incidentally, schematic diagrams showing an outline of the above-described planarization method are shown in FIG. 18, FIG. 19, FIG. 20, and FIG. Here, FIG. 18 shows a flattening method using pressure using a heavy stone part or a pressure plate, FIG. 19 shows a flattening method using a sweeping spatula, and FIG. 20 shows pressurizing using a rotating roller. FIG. 21 shows a flattening method by sweeping using a wound sheet of a rotating roller as a movable sheet. By these methods, the fine needle upper surface, the fine needle mounting allowance upper surface, and the substrate upper surface can be flattened to form a continuous smooth surface. Furthermore, for these flattening methods, a pressurizing mechanism using a heavy stone part or a pressure plate, a sweeping spatula, a sweeping brush, a sweeping mechanism using a sweeping blade, a roller for rotating and pressurizing, for sweeping The fine sugar needle of the present invention can be precisely manufactured at low cost and efficiently using a manufacturing apparatus having a movable sheet that is a wound sheet by a rotating roller used in the above.

  In the fine sugar needle of the present invention, one fine needle is arranged on the side surface of the fine needle mounting allowance made of the same material as the fine needle, or a plurality of the fine needles are arranged in a comb shape, By adopting a structure in which the fine needle mounting allowance is welded to the upper surface side end portion of the substrate made of a material different from the sugar of the fine needle, the fine needle and the fine needle mounting allowance by this welding are made of the same material sugar. Due to the integrated structure, when the fine needle is inserted into the skin, the fine needle is difficult to break and can be easily pierced into the skin, thereby dramatically improving the practicality of the fine sugar needle.

  In the fine saccharide needle of the present invention, one fine needle is arranged on the side surface of the fine needle attachment allowance made of the same material as the fine needle, or a plurality of the fine needles are arranged in a comb shape, The fine needle mounting allowance is welded to the top biting portion of the substrate made of a material different from the sugar of the fine needle, and the fine needle upper surface and the fine needle attaching allowance upper surface are continuously smoothed to achieve a fine structure. Because the needle and the fine needle mounting allowance by this bite are integrated structure made of sugar of the same material, it is difficult to break the fine needle, and when inserting the fine needle into the skin, the fine needle is difficult to break and is easy to pierce the skin As a result, the practicality of the fine saccharide needles has been dramatically improved.

  In the fine sugar needle of the present invention, if the fine attachment allowance surface and the substrate upper surface are both flattened and smoothly connected so that there is no step, the fine needle and the attachment allowance are integrated and become stronger. As a result, cracks hardly occur, the fine needles do not break during skin insertion, and it is easy to pierce the skin, thereby greatly improving the practicality of the fine sugar needles. And, in the fine saccharide needle having the sword-like structure of the present invention, the number of fine needles that pierce the skin increases, so the number of chips such as drugs mounted on the fine saccharide needle also increases, or the fine saccharides Since the weight of the drug contained in the needle also increases, the effect of facilitating the administration of a large amount of drug, nutritional supplement, cosmetic material, and biological substance to the skin is obtained, thereby the practicality of the fine sugar needle Improved significantly. Furthermore, in the fine saccharide needle of the present invention, the effect of further strengthening the fine saccharide needle can be obtained by adopting a substrate composed of a plurality of layers, so that even a thin layer is formed into a plurality of layers. This greatly improved the practicality of the fine sugar needle.

  The fine sugar needle of the present invention has a structure in which a drug, a cosmetic material or the like is made into a chip and adhered by glucose on the fine needle upper surface and the fine needle mounting allowance upper surface, and the fine needle upper surface and the substrate upper surface are connected smoothly. In this case, the chip can be covered and extended to the upper surface of the substrate, and the effect that the amount of administration of a drug or the like can be expanded is obtained. In addition to this effect, since it becomes easy to mount the drug or cosmetic material after molding by heat dissolution, the effect that it is possible to avoid heat deterioration of the drug etc. is obtained. Practicality has improved dramatically.

  In the fine sugar needle of the present invention, as a manufacturing method for making the upper surface of the fine needle, the upper surface of the fine needle mounting allowance, and the upper surface of the substrate coincide with each other without any step, the upper surface of the fine needle and the upper surface of the fine needle attachment allowance In order to flatten the upper surfaces of the substrates by making them coincide with each other without any step, an effect is obtained that can be achieved by performing various pressurizations and sweeps on the upper surfaces. For these flattening methods, pressurization mechanism using weight parts or pressure plate, sweep spatula, sweep brush, sweep mechanism using sweep blade, roller for rotating and pressurizing, for sweeping Using the manufacturing apparatus having the movable sheet that is a wound sheet by the used rotating roller, an effect that the fine sugar needle of the present invention can be manufactured precisely, at low cost and efficiently was obtained.

  Hereinafter, embodiments of the fine sugar needle, the production method, and the production apparatus of the present invention will be described, but the present invention is not limited to the following embodiments.

  In the present invention, the fine saccharide needle means a fine needle composed of a saccharide, and the specific size of the fine needle is as follows: the perpendicular length from the needle tip to the needle bottom is 100 μm to 2 mm, the needle bottom The lateral width is preferably 20 μm to 1 mm, and the needle bottom portion vertical width is preferably 20 μm to 1 mm. FIG. 22 is an enlarged schematic view of the fine needle portion 8 (inside the wavy circle) shown in FIG. 6, but the vertical length 19 from the needle tip to the needle bottom, the needle bottom width 20, the needle The bottom portion vertical width 21 is as illustrated. Further, the shape of the needle bottom surface portion can take various shapes such as a triangular shape, a polygonal shape, and a semicircular shape, and the shape is not particularly limited. Here, when the perpendicular length from the needle tip to the needle bottom is smaller than 100 μm, it is difficult to insert into the skin when the perpendicular length is larger than 2 mm because the thickness is smaller than the unevenness of the skin surface. It is not preferable because it causes pain. In addition, when the width of the bottom surface of the needle is smaller than 20 μm, the needle becomes fragile. When the width of the bottom surface of the needle is larger than 1 mm, insertion into the skin becomes difficult and pain occurs. It is not preferable. Furthermore, when the needle bottom surface length is smaller than 20 μm, the needle becomes fragile, and when the needle bottom surface width is greater than 1 mm, insertion into the skin becomes difficult and pain occurs. It is not preferable for the reason.

  The fine saccharide needle in the present invention is arranged such that one fine needle is arranged on the side surface of the mounting allowance made of the same material as the fine needle, or a plurality of fine needles are arranged in a comb shape. It has a structure in which the mounting allowance is welded to the upper surface side end portion of the substrate made of a material different from the sugar of the fine needle. The term “welding” as used herein literally means that the saccharide, which is the material of the mounting allowance, is melted by moisture absorption or heat, and is bonded to the substrate, which is a material different from the saccharide. Carbohydrates in the state of a role play a role like an adhesive.

  The fine saccharide needle in the present invention is arranged such that one fine needle is arranged on the side surface of the fine needle mounting allowance made of the same material as the fine needle, or a plurality of the fine needles are arranged in a comb shape, The fine needle mounting allowance is welded to the upper biting portion of the substrate made of a material different from the sugar of the fine needle, and the upper surface of the fine needle and the upper surface of the fine needle attaching allowance are continuously smooth. Furthermore, the fine sugar needle has a structure in which the upper surface of the fine needle mounting allowance and the upper surface of the substrate are continuously smooth. In addition, welding here has the same meaning as the above-mentioned welding, and the dissolved saccharide plays a role of an adhesive. In another aspect, the fine sugar needle has a sword mountain structure in which a plurality of substrates are stacked such that the fine sugar needles point in the same direction. Furthermore, another embodiment of the fine sugar needle has a structure in which the substrate of the fine sugar needle is composed of a plurality of layers. Incidentally, the top biting portion of the substrate can be produced by carbon dioxide laser processing (output is about 5 W to 100 W).

  The fine sugar needle of the present invention is characterized in that the substrate material is one or more selected from plastic, wood, metal, paper, polysaccharide material, gelatin, and protein solid. Here, biodegradable plastics such as polypropylene, polyethylene, and polylactic acid are used as plastics, wooden boards for folded lunch boxes, balsa materials as wood, steel, stainless steel, platinum, silver as metals, pullulan and CMC as polysaccharide materials. As the protein solid, collagen, hyaluronic acid, and chitosan can be preferably used.

  The fine sugar needle in the present invention is characterized in that the sugar is maltose and the material of the substrate is paper. Here, anhydrous amorphous maltose can be suitably used as maltose, and sanitary paper for food used for paper cups can be suitably used as paper.

  The fine sugar needle according to the present invention is characterized in that glucose is coated on both upper surfaces of the upper surface of the attachment allowance which forms a continuous smooth surface with the upper surface of the fine needle, and the drug is mounted on the glucose coated surface. The fine saccharide needle of the present invention is characterized in that a drug is contained in the fine needle.

  The fine sugar needle in the present invention is composed of sodium ascorbate, magnesium ascorbate, hyaluronic acid, collagen, human IgG, human IgM, antibody drug, nucleic acid drug, dye, vitamin A, vitamins, insulin, hormone, It is 1 or 2 or more chosen from these, It is characterized by the above-mentioned. Here, human IgG is a drug for blood disorders, human IgM is an anti-inflammatory drug corresponding to a foreign substance, an antibody drug is mainly an anticancer drug, a nucleic acid drug is a DNA therapeutic drug, a dye is indigo, etc. Examples of plant pigments, tattoo pigments, and vitamins include vitamin B and vitamin D, which can be suitably used.

  The fine sugar needle according to the present invention is characterized in that glucose is coated on both upper surfaces of the upper surface of the attachment allowance that forms a continuous smooth surface with the upper surface of the fine needle, and a biological material is mounted on the glucose coated surface. The fine sugar needle in the present invention is characterized in that a biological substance is encapsulated in the fine needle.

  The fine carbohydrate needle in the present invention is characterized in that the biological material is one or more selected from DNA, amino acid, protein, human IgG antibody, vaccine, intracellular microbody, cell and microorganism. Here, Golgi bodies, mitochondria, etc. can be suitably used as the cell microparticles, skin cells, hair root cells, stem cells, etc. as the cells, and lactic acid bacteria, green molds, etc. as the microorganisms.

  The method for producing the fine sugar needle in the present invention includes a method for independently using a die dedicated to the fine needle separated from the substrate when the fine sugar needle is manufactured. , Pressurize and flatten the fine needle upper surface, the fine needle attachment allowance surface, and the substrate upper surface so that the fine needle attachment allowance surface provided on the upper surface side edge of the substrate or the upper surface biting portion of the substrate and the upper surface of the substrate become a smooth surface. It is characterized by using the method to make. Moreover, the fine carbohydrate needle | hook in this invention has a pressurization mechanism with which it uses for said flattening method as the manufacturing apparatus. Here, a heavy stone part or a pressure plate can be suitably used as the pressurizing mechanism.

  The method for producing the fine sugar needle in the present invention includes a method for independently using a die dedicated to the fine needle separated from the substrate when the fine sugar needle is manufactured. In order to make the fine needle mounting allowance upper surface provided on the upper surface side edge or the substrate upper bite and the upper surface of the substrate smooth, the upper surface of the fine needle, the upper allowance surface of the fine needle, and the upper surface of the substrate are swept and flattened. It is characterized by using the method to make. In addition, the fine sugar needle in the present invention is characterized in that, as a manufacturing apparatus thereof, has a sweep mechanism used for the above-described flattening method. Here, a sweeping spatula, a sweeping brush, or a sweeping blade can be suitably used as the sweeping mechanism.

  The method for producing the fine sugar needle in the present invention includes a method for independently using a die dedicated to the fine needle separated from the substrate when the fine sugar needle is manufactured. The fine needle top surface, the fine needle mounting allowance surface, and the substrate top surface are pressurized by a rotating roller so that the fine needle mounting allowance surface provided on the upper surface side edge of the substrate or the substrate upper surface biting portion and the substrate upper surface are smooth. And using a flattening method. In addition, the fine sugar needle according to the present invention is characterized in that the production apparatus has a rotating roller for use in the above-described flattening method.

  The method for producing the fine sugar needle in the present invention includes a method for independently using a die dedicated to the fine needle separated from the substrate when the fine sugar needle is manufactured. The top surface of the fine needle, the top surface of the fine substrate, and the top surface of the fine substrate are swept by a movable sheet so as to make the top surface of the fine needle mounting surface and the top surface of the substrate top surface smooth. And using a flattening method. Moreover, the fine carbohydrate needle | hook in this invention has the movable sheet | seat used for said flattening method as the manufacturing apparatus, It is characterized by the above-mentioned. Here, a wound sheet by a rotating roller can be suitably used as the movable sheet.

  Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited to the following examples.

  About 30 fine needles made of anhydrous amorphous maltose with a vertical length of 500 μm from the needle tip to the needle bottom, a needle bottom width of 100 μm, and a needle bottom length of 100 μm (the needle bottom is triangular) Since the forming of the needle part and the forming of the substrate part are performed separately, in the production by the method of using individual molds independently, the cross section when cut by the plane passing through the vertical line and the vertical width is a mountain shape (the vertical line) A substrate made of food sanitary paper by welding the fine needle attachment allowance by welding on the side of the fine needle attachment allowance made of anhydrous amorphous maltose with a base of 500 μm along the direction and a height of 100 μm along the vertical width direction) (Fine needle having a structure provided on the upper surface side end portion of the horizontal length of 10 mm along the width direction, the vertical length of 10 mm along the bottom direction, and the thickness of 0.5 mm). Make did. When a skin insertion test was performed using this fine sugar needle, the fine needle had sufficient strength, and all 30 fine needles did not break, and even without pain, it was safely applied to the skin. It was confirmed to be stabbed. In addition, since all of these fine needles remaining in the skin were carbohydrates, they immediately dissolved in the skin after insertion.

  About 20 fine needles made of anhydrous amorphous maltose with a perpendicular length from the needle tip to the needle bottom of 500 μm, a needle bottom width of 100 μm, and a needle bottom length of 100 μm (the needle bottom is triangular) Since the forming of the needle part and the forming of the substrate part are performed separately, in the production by the method of using individual molds independently, the cross section when cut by the plane passing through the vertical line and the vertical width is rectangular (the vertical line) A substrate made of food sanitary paper by welding the fine needle attachment allowance by welding on the side of the fine needle attachment allowance made of anhydrous amorphous maltose with a base of 500 μm along the direction and a height of 100 μm along the vertical width direction) Provided in the upper bite portion (width 10 mm along the width direction, length 10 mm along the bottom direction, thickness 0.5 mm), and the upper surface of the fine needle and the upper surface of the fine needle mounting allowance are smooth A fine needle having the above-described structure (a schematic diagram of its outer shape is as shown in FIG. 6) was produced. Note that the above-mentioned substrate top biting portion was produced by carbon dioxide laser processing (output is about 10 W). Further, as a flattening method used for the above smooth structure, the upper surface of the fine needle and the upper surface of the fine needle mounting surface are simultaneously pressed by an apparatus having a pressure mechanism using a pressure plate as a Teflon plate. Was a smooth surface with no steps. At this time, the surface roughness of these upper surfaces could be made within ± 5 μm. When a skin insertion test was performed using this fine sugar needle, the fine needle had sufficient strength, and all of the 20 fine needles did not break, and even without pain, it was safely applied to the skin. It was confirmed to be stabbed. In addition, since all of these fine needles remaining in the skin were carbohydrates, they immediately dissolved in the skin after insertion.

  About 20 fine needles made of anhydrous amorphous maltose with a perpendicular length from the needle tip to the needle bottom of 500 μm, a needle bottom width of 100 μm, and a needle bottom length of 100 μm (the needle bottom is triangular) Since the forming of the needle part and the forming of the substrate part are performed separately, in the production by the method of using individual molds independently, the cross section when cut by the plane passing through the vertical line and the vertical width is rectangular (the vertical line) A substrate made of food sanitary paper by welding the fine needle attachment allowance by welding on the side of the fine needle attachment allowance made of anhydrous amorphous maltose with a base of 500 μm along the direction and a height of 100 μm along the vertical width direction) Provided in the upper bite portion (width 10 mm along the width direction, length 10 mm along the bottom direction, thickness 0.5 mm), and the upper surface of the fine needle and the upper surface of the fine needle mounting allowance are smooth Further, a fine needle having a structure in which the upper surface of the fine needle mounting allowance and the upper surface of the substrate are continuously smoothed (a schematic diagram of the outer shape is as shown in FIG. 6) was produced. Note that the above-mentioned substrate top biting portion was produced by carbon dioxide laser processing (output is about 10 W). Further, as a flattening method used for the smooth structure, the top surface of the fine needle, the top surface of the fine needle mounting surface, and the top surface of the substrate are swept by a device having a sweeping mechanism made of Teflon (thickness: 500 μm). Thus, these upper surfaces were made smooth surfaces without a step. At this time, the surface roughness of these upper surfaces could be made within ± 10 μm. When a skin insertion test was performed using this fine sugar needle, the fine needle had sufficient strength, and all of the 20 fine needles did not break, and even without pain, it was safely applied to the skin. All of the fine needles remaining in the skin were confirmed to be stabbed and dissolved in the skin immediately after insertion because they were carbohydrates.

  Three fine sugar needles of Example 2 were produced by the same method as in Example 2, and three of these substrates were stacked so that the fine sugar needles pointed in the same direction, whereby a sword mountain structure A fine sugar needle having a shape (a schematic view of its outer shape is as shown in FIG. 14). When a skin insertion test was performed using this fine sugar needle, the fine needle had sufficient strength, and all 60 fine needles did not break, and even without pain, it was safely applied to the skin. It was confirmed to be stabbed. In addition, since all of these fine needles remaining in the skin were carbohydrates, they immediately dissolved in the skin after insertion.

  Three fine sugar needles of Example 3 were prepared by the same method as in Example 3, and three of these substrates were stacked so that the fine sugar needles pointed in the same direction. A fine sugar needle having a shape (a schematic view of its outer shape is as shown in FIG. 14). When a skin insertion test was performed using this fine sugar needle, the fine needle had sufficient strength, and all 60 fine needles did not break, and even without pain, it was safely applied to the skin. All of the fine needles remaining in the skin were confirmed to be stabbed and dissolved in the skin immediately after insertion because they were carbohydrates.

  The bottom layer of the substrate is polyethylene (thickness 100 μm), and on the substrate, food hygiene paper (thickness 300 μm), food hygiene paper (thickness 300 μm), and polypropylene (thickness 100 μm) are used for the substrate. Except that, a fine sugar needle having a four-layered substrate (schematic cross-sectional view as shown in FIG. 15) was prepared in the same manner as in Example 3 above. As a result, the substrate, which is food sanitary paper, was not directly touched with a finger, and a fine sugar needle having a substrate with high strength by plastic film coating was obtained. When a skin insertion test was performed using this fine sugar needle, the fine needle had sufficient strength, and all of the 20 fine needles did not break, and even without pain, it was safely applied to the skin. It was confirmed to be stabbed. In addition, since all of these fine needles remaining in the skin were carbohydrates, they immediately dissolved in the skin after insertion.

  As a flattening method used for the smooth structure, an apparatus having a roller wound with a Teflon sheet having a diameter of 1 cm is used to press the upper surface of the fine needle, the upper surface of the fine needle mounting surface, and the upper surface of the substrate with the above rotating roller. A fine sugar needle having a structure in which the upper surface is a smooth surface having no step and the other three upper surfaces are continuously smoothed in the same manner as in Example 3 above (a schematic diagram of the outer shape is shown in FIG. 6). As shown in FIG. At this time, the surface roughness of these upper surfaces could be made within ± 10 μm. When a skin insertion test was performed using this fine sugar needle, the fine needle had sufficient strength, and all of the 20 fine needles did not break, and even without pain, it was safely applied to the skin. It was confirmed to be stabbed. In addition, since all of these fine needles remaining in the skin were carbohydrates, they immediately dissolved in the skin after insertion.

  As a flattening method used for the smooth structure, a fine needle upper surface, a fine needle mounting allowance upper surface and a substrate upper surface are connected to the rotating roller by an apparatus having a stainless steel roller wound with a 50 μm thick Teflon sheet as a movable sheet. A fine sugar needle having a structure in which these upper surfaces are continuously smoothed by the same method as in Example 3 except that the upper surfaces are made smooth with no step by sweeping with a Teflon sheet. The outline of the outline is as shown in FIG. At this time, the roughness of these upper surfaces was able to be a surface accuracy within ± 3 μm. When a skin insertion test was performed using this fine sugar needle, the fine needle had sufficient strength, and all of the 20 fine needles did not break, and even without pain, it was safely applied to the skin. It was confirmed to be stabbed. In addition, since all of these fine needles remaining in the skin were carbohydrates, they immediately dissolved in the skin after insertion.

  Example 7 was used except that 3% by weight of sodium ascorbate was added to anhydrous amorphous maltose as a raw material by the heating dissolution method (after constant heating at 80 ° C. to dissolve the material to be dissolved). In the same manner as above, a fine sugar needle containing sodium ascorbate (schematic diagram of its outer shape is as shown in FIG. 6) was prepared. This fine sugar needle was subjected to an insertion test once a day on a part of the face skin of a female test subject in the 50s for the purpose of skin whitening on the face. As a result of comparative examination by photographing, a whitening effect was confirmed after 100 days.

  Glucose is coated on both upper surfaces of the fine needle upper surface and the fine needle mounting allowance surface using a fine brush for application, and sodium ascorbate is formed in a disk shape (diameter 50 μm, thickness on each of the 20 coated surfaces. 20 μm), each of the fragments (chips) is mounted one by one, and the rest is all in the same manner as in Example 7 above, and a fine saccharide needle mounted with a sodium ascorbate chip (schematic diagram of its cross section) Was prepared as shown in FIG. This fine sugar needle was subjected to an insertion test once a day on a part of the facial skin of a female subject (similar to Example 9) for the purpose of skin whitening on the face. As a result of comparative examination by taking a photograph of the skin, a whitening effect was confirmed after 60 days. This is because vitamin C, which is easily decomposed by heating, such as sodium ascorbate phosphate, is partially decomposed by heating in the method according to Example 9, and the whitening effect is somewhat reduced. It was confirmed that if it was made into a chip and mounted on the glucose-coated surface, it did not undergo a heating process and therefore it was not decomposed and the whitening effect could be sufficiently exhibited.

  Example 7 In which 7% by weight of anhydrous ascorbate magnesium was added to anhydrous amorphous maltose as a raw material by the heating dissolution method (after constant heating at 80 ° C., dissolution was performed) In the same manner as above, a fine sugar needle containing magnesium ascorbate (a schematic diagram of its outer shape is as shown in FIG. 6) was produced. With respect to this fine sugar needle, an insertion test was conducted once a day on a part (stain part) of the skin of the face of a female subject (similar to Example 9) for the purpose of removing stains on the face. As a result of a comparative examination by photographing the skin in the vicinity of the insertion site, it was confirmed that the brown stain on the face had faded after 60 days.

  Glucose is coated on both upper surfaces of the fine needle upper surface and the fine needle mounting allowance surface using a fine brush for coating, and a mixed material of maltose and pullulan (mixing weight ratio 1: 1) is coated on each of the 20 coated surfaces. ) Containing human IgG antibody in 0.25% by weight in the form of a disc (diameter 50 μm, thickness 20 μm) in pieces (chips) one by one. In the same manner as above, a fine carbohydrate needle (with a schematic cross-sectional view of its outer shape as shown in FIG. 17) on which an IgG antibody-containing chip was mounted was prepared. Using this fine saccharide needle, an In-Vivo experiment was conducted in which it was administered to the skin of a rat, and human IgG antibody was confirmed in the skin. This method made it possible to apply human tests.

  Using a raw material that contains 10 μg of estrodiol (a kind of hormone) in anhydrous amorphous maltose by the heat dissolution method (dissolve the material to be dissolved after constant heating at 100 ° C.). In the same manner as in Example 7, a fine sugar needle containing estrodiol (schematic diagram of its outer shape is as shown in FIG. 6) was prepared. As a result, it was confirmed that although it was extremely difficult to administer the hormone in the order of μg by conventional injection, it can be accurately administered to the human body by adjusting the number of fine needles containing the hormone.

  Example 7 In the above-described Example 7 except that 1% by weight of red edible preparation was added to anhydrous amorphous maltose as a raw material by the heat dissolution method (after constant heating at 110 ° C., the material to be dissolved was dissolved). In the same manner as above, a fine sugar needle containing the above red pigment (schematic diagram of its outer shape is as shown in FIG. 6) was prepared. When this fine sugar needle is inserted into a part of the skin of the back of a female subject (similar to Example 9) for the purpose of whether or not safe tattooing is possible, red pigment remains on the skin stratum corneum. It was confirmed visually that it was obtained. As a result, it was confirmed that safe and simple tattooing is possible, and that any notation can be made in the skin by selecting a pigment.

  Glucose is coated on both upper surfaces of the fine needle upper surface and the fine needle mounting allowance surface with a fine brush for application, and hyaluronic acid is formed in a disk shape (diameter 50 μm, thickness 20 μm) on each of the 20 coated surfaces. ), Each of the fragments (chips) is mounted one by one, and the rest is all performed in the same manner as in Example 7 above, and a fine saccharide needle having a hyaluronic acid chip mounted thereon (a schematic diagram of its cross section is shown in FIG. As shown in FIG. This fine sugar needle was subjected to an insertion test once a day on a part of the skin of a female subject (similar to Example 9) for the purpose of skin beautification on the face. As a result of the comparative examination by photography, the skin beautifying effect (skin gloss) was confirmed after 60 days. This means that even if it is easily decomposed by heating, such as hyaluronic acid, if it is chipped and mounted on the glucose-coated surface as in this example, it will not be decomposed because it does not go through the heating process, and it has a beautiful skin effect. It was confirmed that can be sufficiently exerted.

  Glucose is coated on both upper surfaces of the fine needle upper surface and the fine needle mounting allowance surface using a fine brush for coating, and 1% by weight of carotenoid (a kind of vitamin A) is added to maltose on each of the 20 coated surfaces. Each of the contained elements is mounted in a disk shape (diameter 50 μm, thickness 20 μm) into pieces (chips) one by one, and all the others are mounted in the same manner as in Example 7 above. Fine sugar needles (schematic cross-sectional view as shown in FIG. 17) were prepared. When an In-Vivo experiment was performed using this fine saccharide needle to administer a part of the skin of the upper arm of a person, it was confirmed that a carotenoid as a nutrient could remain in the horny layer of the skin.

  Glucose is coated on both upper surfaces of the fine needle upper surface and the fine needle mounting allowance surface using a fine brush for application, and each of the 20 coated surfaces is made of a maltose containing 20% by weight of insulin. Fine sugar needles loaded with insulin-containing chips in the same manner as in Example 7 except that one piece (chip) in a plate shape (diameter 50 μm, thickness 20 μm) is mounted one by one. (A schematic diagram of the cross section is as shown in FIG. 17). An In-Vivo experiment in which a fine sugar needle was used to administer to a part of the skin of a rat was conducted, and it was confirmed that insulin could remain in the skin stratum corneum. This is because even if it is easily decomposed by heating such as insulin, if it is chipped and mounted on the glucose-coated surface as in this example, it will not be decomposed because it does not go through the heating process, and the medicinal properties of insulin. It was confirmed that can be fully exerted in the human body.

  Glucose is coated on both upper surfaces of the fine needle upper surface and the fine needle mounting allowance surface using a fine brush for coating, and collagen is formed in a disk shape (diameter 50 μm, thickness 20 μm) on each of the 20 coated surfaces. Each of the fragments (chips) was loaded one by one, and the rest were all performed in the same manner as in Example 7, except that a fine carbohydrate needle (with a schematic cross-sectional view of FIG. Street). It was confirmed that collagen could remain in the skin stratum corneum when it was inserted into a part of the upper arm skin using this fine sugar needle. This means that even if it is easily decomposed by heating such as collagen, which is a protein, if it is chipped and mounted on the glucose-coated surface as in this example, it will not be decomposed because it does not go through the heating process, It was confirmed that the protein could remain in the skin without alteration.

  Glucose is coated on both upper surfaces of the fine needle upper surface and the fine needle mounting allowance surface with a fine brush for application, and each of the 20 coated surfaces is made of a circle containing 3% by weight of maltose vaccine. Fine saccharide needles loaded with vaccine-containing chips in the same manner as in Example 7 except that one piece (chip) in a plate shape (diameter 50 μm, thickness 20 μm) is mounted one by one. (A schematic diagram of the cross section is as shown in FIG. 17). Using this fine saccharide needle, an In-Vivo experiment was conducted in which it was administered to a part of the skin of a rat, and it was confirmed that the vaccine could remain in the skin stratum corneum. This means that even if it is easily decomposed by heating like a vaccine, if it is chipped and mounted on the glucose-coated surface as in this example, it will not be decomposed because it does not go through the heating process, and the activity of the vaccine It was confirmed that the vaccine could remain in the stratum corneum without reducing the degree.

  The fine sugar needle, the production method and the production apparatus of the present invention have the above-mentioned various characteristic effects, and can be used in the medical field, the beauty field, and the cosmetic field. The fine sugar needle of the present invention can be mass-produced by the production method and apparatus of the present invention and can be used industrially.

  It is the schematic which shows the external shape of the conventional fine carbohydrate needle | hook.   It is the schematic which shows the cross section of the conventional fine carbohydrate needle | hook.   It is the schematic which shows the cross section of the fine carbohydrate needle | hook which mounts the conventional chemical | medical agent chip | tip.   It is the schematic which shows the external shape of the fine saccharide needle which has the fine needle attachment allowance of this invention.   It is the schematic which shows the external shape of the fine saccharide needle which has the fine needle attachment allowance of this invention.   It is the schematic which shows the external shape of the fine saccharide needle which has the fine needle attachment allowance of this invention.   It is the schematic which shows the cross section of the fine saccharide needle which has the fine needle attachment allowance of this invention.   It is the schematic which shows the external shape of the fine saccharide needle which has the fine needle attachment allowance of this invention.   It is the schematic which shows the external shape of the fine saccharide needle which has the fine needle attachment allowance of this invention.   It is the schematic which shows the cross section of the fine saccharide needle which has the fine needle attachment allowance of this invention.   It is the schematic which shows the cross section of the fine saccharide needle which has the fine needle attachment allowance of this invention.   It is the schematic which shows the cross section of the fine saccharide needle which has the fine needle attachment allowance of this invention.   It is the schematic which shows the cross section of the fine saccharide needle which has the fine needle attachment allowance of this invention.   It is the schematic which shows the external shape of the fine sugar needle | hook which has a sword mountain-like structure of this invention.   It is the schematic which shows the cross section of the fine carbohydrate needle | hook which has the board | substrate which consists of multiple layers of this invention.   It is the schematic which shows the cross section of the fine carbohydrate needle | hook carrying the chemical | medical agent chip | tip of this invention.   It is the schematic which shows the cross section of the fine carbohydrate needle | hook carrying the chemical | medical agent chip | tip of this invention.   It is a schematic diagram which shows the outline of the planarization method by pressurization of this invention.   It is a schematic diagram which shows the outline of the planarization method by sweep of this invention.   It is a schematic diagram which shows the outline of the planarization method by the pressurization using the rotating roller of this invention.   It is a schematic diagram which shows the outline of the planarization method by sweep using the movable sheet | seat of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Fine sugar needle 2 Board | substrate 3 Adhesion site | part 4 Drug chip 5 Fine needle | hook 6 The fine needle attachment allowance welded to the board | substrate upper surface side edge 7 The fine needle attachment allowance welded to the board | substrate upper surface biting part 8 Fine needle part (wavy line shape) (Within circle)
9 Substrate consisting of multiple layers 10 Glucose-coated surface 11 Pressure mechanism 12 that is a cobblestone or pressure plate 13 Arrow that indicates pressure direction 13 Sweep mechanism that is a sweeping spatula 14 Arrow that indicates sweep direction 15 Rotating roller 16 Rotating roller indicates moving direction Arrow 17 Rolled sheet 18 by rotating roller Arrow 19 indicating the sweep direction of the rotating roller 19 Vertical length from the needle tip to the needle bottom 20 Needle bottom width 21 Needle bottom width

Claims (21)

  A fine needle made of a saccharide having a perpendicular length from the needle tip to the needle bottom of 100 μm to 2 mm, a width of the needle bottom of 20 μm to 1 mm, and a length of the needle bottom of 20 μm to 1 mm is different from the saccharide. A fine carbohydrate needle characterized by having a structure in which one or a plurality of combs are arranged on the side surface of the sugar fine needle mounting allowance welded to the upper surface side end portion of the substrate.   A fine needle made of a saccharide having a perpendicular length from the needle tip to the needle bottom of 100 μm to 2 mm, a width of the needle bottom of 20 μm to 1 mm, and a length of the needle bottom of 20 μm to 1 mm is different from the saccharide. One or a plurality of combs are arranged on the side surface of the sugar fine needle mounting allowance welded to the upper surface biting portion of the substrate, and the upper surface of the fine needle and the upper surface of the fine needle mounting allowance are continuous. A fine sugar needle characterized by a smooth structure.   3. The fine sugar needle according to claim 2, wherein the fine needle mounting allowance upper surface and the substrate upper surface have a smooth structure.   4. The fine sugar needle according to claim 2, wherein the fine sugar needle has a sword mountain structure in which a plurality of the substrates are stacked so that the fine sugar needle points in the same direction.   The fine carbohydrate needle according to any one of claims 1 to 4, wherein the substrate comprises a plurality of layers.   6. The fine carbohydrate according to claim 1, wherein the material of the substrate is one or more selected from plastic, wood, metal, paper, polysaccharide material, gelatin and protein solids. needle.   The fine carbohydrate needle according to any one of claims 1 to 5, wherein the carbohydrate is maltose, and the material of the substrate is paper.   The glucose is coated on both upper surfaces of the upper surface of the fine needle mounting allowance that forms a continuous smooth surface with the upper surface of the fine needle, and a drug is mounted on the glucose-coated surface. Fine sugar needles.   The fine sugar needle according to any one of claims 1 to 7, wherein a drug is contained inside the fine needle.   The drug is one or more selected from sodium ascorbate, magnesium ascorbate, hyaluronic acid, collagen, human IgG, human IgM, antibody drug, nucleic acid drug, dye, vitamin A, vitamins, insulin, hormone. The fine carbohydrate needle according to claim 8 or 9, characterized in that.   8. The glucose is coated on both upper surfaces of the upper surface of the fine needle mounting allowance that forms a continuous smooth surface with the upper surface of the fine needle, and a biological material is mounted on the glucose-coated surface. The fine sugar needle described.   The fine carbohydrate needle according to any one of claims 1 to 7, wherein a biological substance is encapsulated inside the fine needle.   13. The fine carbohydrate needle according to claim 11 or 12, wherein the biological material is one or more selected from DNA, amino acids, proteins, human IgG antibodies, vaccines, intracellular microbodies, cells and microorganisms. .   In the method of independently using a mold dedicated to a fine needle separated from a substrate when manufacturing a fine sugar needle, the upper surface of the fine needle and the substrate upper surface side edge portion or the substrate upper surface biting portion after the mold separation are used. A method of pressing and flattening the upper surface of the fine needle, the upper surface of the fine needle mounting allowance, and the upper surface of the substrate so as to make the provided upper surface of the fine needle attaching surface and the upper surface of the substrate smooth. A method for producing a fine sugar needle.   In the method of independently using a mold dedicated to a fine needle separated from a substrate when manufacturing a fine sugar needle, the upper surface of the fine needle and the substrate upper surface side edge portion or the substrate upper surface biting portion after the mold separation are used. Pressurizing mechanism for use in a method of pressurizing and flattening the upper surface of the fine needle, the upper surface of the fine needle mounting allowance, and the upper surface of the substrate so that the upper surface of the fine needle attaching allowance and the upper surface of the substrate are made smooth. An apparatus for producing a fine sugar needle, comprising:   In the method of independently using a mold dedicated to a fine needle separated from a substrate when manufacturing a fine sugar needle, the upper surface of the fine needle and the substrate upper surface side edge portion or the substrate upper surface biting portion after the mold separation are used. A method of sweeping and flattening the upper surface of the fine needle, the upper surface of the fine needle mounting allowance, and the upper surface of the substrate so as to make the provided upper surface of the fine needle mounting allowance and the upper surface of the substrate smooth. A method for producing a fine sugar needle.   In the method of independently using a mold dedicated to a fine needle separated from a substrate when manufacturing a fine sugar needle, the upper surface of the fine needle and the substrate upper surface side edge portion or the substrate upper surface biting portion after the mold separation are used. A sweep mechanism for sweeping and flattening the upper surface of the fine needle, the upper surface of the fine needle attachment, and the upper surface of the substrate so that the provided upper surface of the fine needle attachment surface and the upper surface of the substrate are smooth surfaces; An apparatus for producing a fine sugar needle, comprising:   In the method of independently using a mold dedicated to a fine needle separated from a substrate when manufacturing a fine sugar needle, the upper surface of the fine needle and the substrate upper surface side edge portion or the substrate upper surface biting portion after the mold separation are used. In order to make the provided upper surface of the fine needle mounting surface and the upper surface of the substrate smooth, a method is used in which the upper surface of the fine needle, the upper surface of the fine needle mounting surface, and the upper surface of the substrate are pressed and flattened by a rotating roller. A method for producing a fine saccharide needle.   In the method of independently using a mold dedicated to a fine needle separated from a substrate when manufacturing a fine sugar needle, the upper surface of the fine needle and the substrate upper surface side edge portion or the substrate upper surface biting portion after the mold separation are used. In order to make the provided upper surface of the fine needle mounting surface and the upper surface of the substrate a smooth surface, the fine needle upper surface, the upper surface of the fine needle mounting surface, and the upper surface of the substrate are pressed and flattened by a rotating roller. An apparatus for producing a fine sugar needle, comprising a rotating roller.   In the method of independently using a mold dedicated to a fine needle separated from a substrate when manufacturing a fine sugar needle, the upper surface of the fine needle and the substrate upper surface side edge portion or the substrate upper surface biting portion after the mold separation are used. A method of sweeping and flattening the upper surface of the fine needle, the upper surface of the fine needle attachment, and the upper surface of the substrate with a movable sheet is used to make the provided upper surface of the fine needle attachment surface and the upper surface of the substrate smooth. A method for producing a fine saccharide needle.   In the method of independently using a mold dedicated to a fine needle separated from a substrate when manufacturing a fine sugar needle, the upper surface of the fine needle and the substrate upper surface side edge portion or the substrate upper surface biting portion after the mold separation are used. Provided with a method of sweeping and flattening the upper surface of the fine needle, the upper surface of the fine needle attachment, and the upper surface of the substrate with a movable sheet so that the provided upper surface of the fine needle attachment surface and the upper surface of the substrate are smooth. An apparatus for producing a fine carbohydrate needle, comprising a movable sheet.

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