JP2009136874A - Coating sheet processing apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a coating sheet processing apparatus in which two or more kinds of coating materials such as coating liquids are separately applied in layers without mixing coating materials in such a case of separately applying in layers without mixing creamy medicines such as adhesive and ointment. <P>SOLUTION: The continuous coating apparatus has a first sheet supply apparatus for supplying a first long-sized sheet, a second sheet supply apparatus for supplying a second long-sized sheet, a first coating apparatus for applying a first coating material on the first sheet to form a first coating layer, a second coating apparatus arranged successively after the first coating apparatus and for applying a second coating material on the first coating layer in layers to form a second coating layer and a covering apparatus for covering the second coating layer which is coated in layers on the first layer with the second sheet to form a coating sheet. One of the first and second coating apparatus is an intermittent coating apparatus for intermittently coating one of the first and second coating material and the other is a continuous coating apparatus for continuously coating the coating material. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a coating sheet processing apparatus, and more specifically, a base sheet supplying apparatus that holds a long base sheet and pulls out and supplies the base sheet, and a long cover A cover film supply device that holds a film and pulls out and supplies the cover film, and at least one of two types of coating materials such as a coating solution containing a creamy drug on the base sheet or the cover film is doubled. In addition to coating, a layer of a coating containing a creamy drug is applied intermittently, and a layer of other coating is applied continuously with a coating device and these coatings are applied. The present invention relates to a coating sheet processing apparatus having a coating apparatus that coats the surface of a processed base sheet or cover film with a cover film or a base sheet, respectively, to form a coating sheet.

  Applying coating materials such as various coating liquids to a sheet-like material such as cloth (woven fabric, non-woven fabric), paper, metal, or plastic film is widely performed in various technical fields. In particular, in the field of pharmaceuticals, a coating containing a drug such as an anti-inflammatory analgesic was applied to a base sheet or cover film such as a nonwoven fabric or a woven fabric, and a cover film or base sheet was provided on the surface thereof, respectively. Plasters and ointments such as plaster and ointment cure poultices to relieve muscle fatigue, joint pain, low back pain, shoulder pain, knee pain, neuralgia, etc., burns, trauma, skin diseases, etc. It is widely used as a therapeutic drug.

  In such a patch, when it is necessary to use two or more kinds of drugs, for example, a water-soluble drug and a fat-soluble drug at the same time for treatment in the prior art, these two or more kinds of drugs are mixed. A single coating solution was then applied to the base sheet or cover sheet. However, there is a difference in drug efficacy, for example, drug release properties, when using two types of drugs such as water-soluble drugs and fat-soluble drugs in a mixed manner and when using them in combination. And the original effects of these drugs could not be enhanced. Therefore, by devising the property characteristics of these drugs in formulation, it is possible to provide a new formulation design in the field of treatment. However, in the conventional apparatus, two types of drugs are separately stacked without mixing. Could not be applied.

  As a coating apparatus for applying a coating liquid to a base sheet or a cover film, various coating apparatuses are known. For example, “Discharge-type coating apparatus” disclosed in Patent Document 1 Etc. are known. The coating apparatus disclosed in Patent Document 1 is also referred to as a die coating apparatus, and in the present invention, when intermittent coating is performed by the die coating apparatus, the end portion of the coating section is not blurred. Therefore, immediately before the end of the coating section, the suction valve provided in the branch pipe is instantaneously opened to make a negative pressure, thereby reliably cutting off the coating liquid.

  Further, for example, Patent Document 2, Patent Document 3, Patent Document 4, and Patent Document 5 disclose specific examples of coating apparatuses such as a die coating apparatus and a roll coating apparatus that perform intermittent coating. However, when both of these coating apparatuses are used in combination with two or more kinds of chemicals, these two or more kinds of chemicals are mixed and applied to the base sheet or cover sheet as a single coating liquid. However, it was not intended to apply two or more kinds of medicines in layers, and it was never considered to apply two or more kinds of medicines in multiple layers.

JP 2001-179156 A Japanese Patent No. 2917127 JP-A-8-257463 JP-A-8-257464 JP 2001-293411 A

  The object of the present invention is to solve the above-mentioned problems of the prior art and to separate two or more types of drugs, for example, water-soluble drugs and fat-soluble drugs, cream-type drugs such as adhesives and ointments, and the like separately. It is an object of the present invention to provide a coating sheet processing apparatus capable of separately coating two or more kinds of coating materials such as coating liquids without mixing them, as in the case of coating in layers.

  In order to solve the above-described problems, the present invention holds a long first sheet, pulls out and supplies the first sheet, and holds a long second sheet. A second sheet supply device that pulls out and supplies the second sheet; a first coating device that forms a first coating layer by applying a first coating on the first sheet; and the first coating device. A second coating device which is arranged continuously on a coating device and forms a second coating layer by coating a second coating on the first coating layer on the first sheet. A coating device for forming a coating sheet by coating the second coating layer coated on the first coating layer with the second sheet, the first sheet being a roll When the second sheet is a roll-shaped long cover film, the first coating device is the first long sheet. A continuous coating apparatus for continuously coating a workpiece, and the second coating apparatus is an intermittent coating apparatus for intermittently coating the second coated article, and the first sheet is When it is a roll-shaped long cover film and the second sheet is a roll-shaped long base sheet, the first coating device applies the first coated material intermittently. And providing a coating sheet processing apparatus, wherein the second coating apparatus is a continuous coating apparatus that continuously coats the second coated product. It is.

  The present invention also includes a first sheet supply device that holds a long base film, and pulls out and supplies the base film, and a second sheet that holds the long cover film and pulls out and supplies the cover film. A supply device, a support sheet supply device that holds a long base material sheet, and draws out and supplies the equipment sheet, and a first coating layer is formed by applying a first coating on the base film. The first coating device to be formed and the first coating device are continuously arranged, and the second coating material is applied to the second coating layer on the first coating layer on the base film. A second coating device for forming a coating layer, and a coating for forming a coating sheet by covering the second coating layer coated on the first coating layer with the second sheet An apparatus, and the first coating layer of the base film in the coating sheet; An adhesive roll for attaching the support sheet to the opposite surface, and the first coating device is a continuous coating device for continuously coating the first coated material, and the second The coating apparatus provides a coating sheet processing apparatus that is an intermittent coating apparatus that intermittently coats the second coated product.

  Further, the coating sheet is a patch sheet, the base sheet is a support sheet made of a nonwoven fabric or a woven fabric, and the coated material coated by the continuous coating apparatus is an adhesive. In addition, it is preferable that the coated material to be applied by the intermittent coating apparatus is a creamy medicine.

  In addition, a sensor is provided on the downstream side of the intermittent coating apparatus along the conveyance direction of the first sheet to detect front and rear ends of the coated material applied by the intermittent coating apparatus, and the intermittent When the coating length and the coating interval of the coated material coated by the coating device are equal, the sensor is moved from the position of the discharge port of the intermittent coating device along the conveyance direction of the first sheet. When the sensor detects a front end portion of a coating applied by the intermittent coating apparatus, the coating by the intermittent coating apparatus is stopped when the sensor is disposed at a position separated by the coating length, and the sensor However, it is preferable that the application by the intermittent coating apparatus is started when the rear end portion of the coated material applied by the intermittent coating apparatus is detected.

  As described in detail above, according to the present invention, two or more kinds of drugs, for example, water-soluble drugs and fat-soluble drugs, cream-type drugs such as adhesives and ointments, and the like are separately mixed. As in the case of coating in layers, it is possible to provide a coating sheet processing apparatus that can coat and coat two or more types of coating materials separately without mixing them. It has a great effect.

It is a front view which shows the whole one Embodiment of the coating sheet processing apparatus of this invention. It is a front view which shows an example of the coating apparatus in the coating sheet processing apparatus of this invention. (A) And (b) is a typical top view of one Example of the coated base material sheet manufactured with the coating sheet processing apparatus of this invention. (A) And (b) is the typical perspective view and typical sectional view of one Example of the patch manufactured with the coating sheet processing apparatus of this invention. It is a front view which shows the other Example of the coating sheet processing apparatus of this invention. It is typical sectional drawing of the other Example of the patch manufactured with the coating sheet processing apparatus of this invention. It is a front view which shows the other Example of the coating sheet processing apparatus of this invention.

The coating sheet processing apparatus and patch according to the present invention will be described below in detail based on preferred embodiments shown in the accompanying drawings.
First, the coated sheet processing apparatus of the present invention will be described.
Below, about the coating sheet processing apparatus of this invention, it has a layer of chemical | medical agents, such as an anti-inflammatory agent, on base material sheets, such as a nonwoven fabric, and the patch sheet formed by coat | covering the cover film used as a peeling sheet on it. Although described as a representative example, it is needless to say that the present invention is not limited to this.

FIG. 1 is a front view schematically showing an entire embodiment of a coating sheet processing apparatus of the present invention, and FIG. 2 shows an example of a coating apparatus used in the coating sheet processing apparatus. It is a front view shown graphically.
As shown in FIG. 1, a coated sheet processing apparatus 10 of the present invention is provided with a base sheet supply apparatus 12 that supplies a base sheet 14 at the left end in the figure, and is disposed in the base sheet supply apparatus 12. The base film 14 unwound from the rolled base sheet roll and supplied to the base sheet 14 is coated with a cream-like medicine as a coating solution by the coating device 16, and the cover film supply device A patch sheet, which is a coated sheet, by covering the surface coated with the drug with the cover film 20 unwound from a long cover film wound in a roll and disposed in 18 22 is formed.

  The base sheet supply device 12 holds a long base sheet 14 wound in a roll shape, and unwinds and supplies the roll base sheet 14. The material sheet rolls 14a and 14b are disposed on the left and right. When the supply of the base sheet 14 from one base sheet roll 14a or 14b is completed, the base sheet 14 is immediately supplied from the other base sheet roll 14b or 14a. The replacement from the base sheet roll 14a to the base sheet roll 14b or the base sheet roll 14b to the base sheet roll 14a is performed as a spare for replacement. It can carry out by arbitrary methods, such as adhere | attaching the starting end part of the base material sheet roll 14b or 14a with a double-sided tape to the terminal part from 14a or 14b.

  The cover film supply device 18 has substantially the same structure as the base sheet supply device 12, and similarly to the base sheet supply device 12, the two cover film rolls 20 a and 20 b are arranged on the left and right sides. ing. The two cover film rolls 20a, 20b in the cover film supply device 18 are also finished when the supply of the cover film 20 from one cover film roll 20a (20b) is completed, as in the case of the base sheet supply device 12. Immediately after the other cover film roll 20b (20a), the cover film 20 is disposed as a spare for replacement, and the replacement can be performed in the same manner.

The base sheet supply device 12 and the cover film supply device 18 have various control mechanisms for unwinding the base sheet 14 or the cover film 20 with a predetermined tension. Since various control methods are known for these control mechanisms, detailed description thereof is omitted here.
In addition, the base material sheet 14 applicable in the present embodiment may be a woven fabric or a non-woven fabric serving as a support for the patch as long as it is difficult to cause elongation or deformation. However, when a support such as a woven fabric or a non-woven fabric used for a patch is very soft and easily stretches or deforms, a base film that is relatively difficult to stretch or deform is used as the base sheet 14. You may make it affix a support body sheet | seat on the surface by the side of the coating liquid non-coating surface side of the base film which is the base material sheet 14, after double-coating two types of coating liquids. An example in which the support sheet is attached to the surface of the base sheet 14 on which the two types of coating liquids are double-coated, on the coating liquid non-coating surface side will be described later.

  The coating device 16 double coats the coating solution on the substrate sheet 14 that is unwound from the substrate sheet supply device 12 and supplied with a coating solution containing a cream-like agent such as an anti-inflammatory agent. The coated base material sheet 15 is formed, and the base material sheet 14 unwound from the base material sheet supply device 12 is supported by a backup roll 24 and is the first coating device. The pressure-sensitive adhesive is applied as a first layer by the continuous coating die coating device 28, and then supported by the backup roll 26, and is applied to the intermittent coating die coating device 30 which is the second coating device in the form of a cream such as an anti-inflammatory agent. The coating liquid containing the drug (drug cream) is intermittently applied as the second layer.

  The coated base sheet 15 coated with the pressure-sensitive adhesive and the chemical cream (coating liquid) by the die coating devices 28 and 30, respectively, is coated with the coating roll 32 and the backup roll 26 constituting the coating device. Covering with the cover film 20 unwound from the cover film supply apparatus 18, the patch sheet | seat 22 which is a coating sheet is formed. In the coating apparatus, the coated base sheet 15 coated with the chemical cream is applied to the backup roll 26 and the cover film 20 unwound from the cover film supply apparatus 18 is applied to the coating roll 32 in the coating apparatus. By being wound and sent, the base sheet 14 and the cover film 20 are overlapped between the backup roll 26 and the covering roll 32. The patch sheet 22 is supported and conveyed from below by a conveying device such as a belt conveying device 34 so as not to be stretched or deformed as much as possible.

In the coating apparatus 16 of this embodiment, the first coating apparatus is a continuous coating die coating apparatus 28 and the second coating apparatus is an intermittent coating die coating apparatus 30, which is shown in detail in FIG. 2. As described above, two die coating devices 28 and 30 are arranged in succession and have two backup rolls 24 and 26 corresponding to the two die coating devices 28 and 30.
The upstream die coating apparatus 28 is controlled by the control means 36 and continuously applies the adhesive 40 (first coating liquid) to the surface of one side of the base sheet 14 in a uniform thickness. The pressure-sensitive adhesive layer 41 is formed. At this time, in this embodiment, as shown in FIGS. 3A and 3B, there is an adhesive on the predetermined width on both sides of the base sheet 14 in the width direction (direction perpendicular to the longitudinal direction as the transport direction). 40 may not be applied, or an adhesive may be applied to the entire surface of one side of the base sheet 14.

  On the other hand, as shown in FIG. 2, the downstream die coating apparatus 30 is controlled by the control means 38, and the drug cream 42 (second coating liquid) is formed on the upper surface of the adhesive layer 41 formed on the base sheet 14. ) To a uniform thickness at a predetermined width and a predetermined interval to form a drug cream layer 43. At this time, in this embodiment, as shown in FIGS. 3A and 3B, the drug cream layer 43 extends over one or two rows in the center on the adhesive layer 41 on the base sheet 14. It is formed at a predetermined interval. Here, on the adhesive layer 41 on the base material sheet 14, the length in the transport direction of the drug cream layer 43 and the interval between the drug cream layers 43 are equal, and the width of the drug cream layer 43 is the same as that of the drug cream layer 43. It is preferably half the width of the pressure-sensitive adhesive layer 41 on one side that is not formed, and equal to the total width of the pressure-sensitive adhesive layers 41 on both sides.

  For example, as shown in FIG. 3B, when the drug cream layer 43 is intermittently formed on the adhesive layer 41 of the base sheet 14 over two rows, the width of the base sheet 14 is set to 300 mm, The width of the adhesive layer is 280 mm, the length (coating length) a of the single drug cream layer 43 is 50 mm, the width is 70 mm, and the distance in the transport direction between the drug cream layers 43 (coating interval) b 50 mm, the width in the width direction between the drug cream layers 43 can be 70 mm, and the width of one side of the adhesive layer 41 on both sides of the drug cream layer 43 in the width direction can be set to 70 mm. However, the present invention is limited to this. It is not done.

  That is, as shown in FIG. 2 and FIG. 3 (b), in the upstream coating die coater 28 that is the first coating device, the adhesive 40 (first coating solution) is applied to the base sheet 14. The die coater 30 for intermittent application on the downstream side, which is a second coating device, is applied to the base sheet 14 with a predetermined width and continuously applied in a uniform thickness in the transport direction. For example, the drug cream 42 (second coating liquid) is placed on the agent 40 in the above-described predetermined size from the rear position by a predetermined length (coating interval) b from the rear end of the previous drug cream layer 43. It is applied on the pressure-sensitive adhesive layer 41 by a predetermined length a (coating length).

Such application amount (thickness and length) of the adhesive 40 and the drug cream 42 is controlled by, for example, one or both of the backup roll 24 and the backup roll 26, or a major roll provided above the backup roll 24. The conveyance speed (or conveyance length) of the base material sheet 14 is measured by an encoder (not shown) provided in the figure (not shown), and the control means 36 and the control means 38 according to this measure the die coating device 28 and the die coating device 30. This is done by controlling the operation.
It should be noted that the coating width (length in the width direction) of the adhesive 40 and the coating width of the drug cream 42 and the interval between the coating widths are the structures of the coating heads of the die coating device 28 and the die coating device 30, respectively, for example, It is set by the width of the outlet and the interval between the discharge ports. Therefore, when changing the coating width of the adhesive 40 and the chemical cream 42 and the interval between the coating widths, it is preferable to replace the coating heads of the die coating device 28 and the die coating device 30, for example, the discharge ports.

  Here, in particular, the control of the coating start position and the coating amount (thickness and length) of the drug cream 42 applied on the adhesive layer 41 is provided on the downstream side of the die coating device 30. The sensor 39 detects the front and rear ends of the adhesive 40 applied to the base sheet 14, and the detection result and data on the conveyance speed (or length) of the base sheet 14 (preferably on the backup roll 26). Preferably, the control means 38 calculates the application timing of the drug cream 42 from the attached encoder) and controls the die coating apparatus 30. For example, the rear end portion of the drug cream 42 is detected by the sensor 39, and the coating start position is controlled based on the detection result, and the coating speed (length) data (data from the encoder) of the base sheet 14 is applied. The amount of work (thickness and length) may be controlled.

When the coating length a of the chemical cream 42 is equal to the coating interval b, the sensor 39 is disposed at a position separated from the position of the discharge port of the die coating apparatus 30 by the coating length a. When the front end of the previous drug cream layer 43 is detected, the application of the drug cream 42 by the die coating apparatus 30 is stopped, and when the sensor 39 detects the rear end, the application of the drug cream 42 by the die coating apparatus 30 is stopped. May be started.
Alternatively, without using the sensor 39, the control means 38 operates the die coating apparatus 30 according to the data (data from the encoder) of the conveyance speed (length) of the base sheet 14, so as to obtain a predetermined coating position. It may be.

  The cover film 20 is covered on the surface on which the adhesive 40 and the drug cream 42 are applied in an overlapping manner. When the base sheet 14 is a support such as a nonwoven fabric or a woven fabric, the patch sheet 22 in which the base sheet 14, the adhesive layer 41, the drug cream layer 43, and the cover film 20 are sequentially laminated is formed. . That is, a long coated sheet before being individually cut as a patch is formed in which the cover film 20 is coated on the surface of the base sheet 14 to which the adhesive layer 41 and the drug cream layer 43 are applied. .

  Further, a die coating apparatus using a wide and long base sheet 14 and providing a plurality of die coating apparatuses 30 at a predetermined interval in the width direction of the base sheet 14, or a die coating apparatus 30 having a plurality of discharge ports of a predetermined width at a predetermined interval. By using this, the above-described drug cream layer 43, that is, the drug cream coating part (the part where the drug cream is applied) is formed in a wide and long coating in which a plurality of drug cream application parts are formed in the width direction. Work sheet can be obtained. Here, the adhesive may be applied to the wide and long base sheet 14 by a plurality of die coaters 28. Note that the wide and long base sheet 14 may be cut into a plurality of rows by a slitter, and the die coating devices 28 and 30 may be provided for each row of the base sheet 14.

  As shown in FIG. 2, the die coating apparatuses 28 and 30 of the present embodiment have dies 44 and 46 and applicators 45 and 47, respectively, and are supplied from the applicators 45 and 47. The pressure-sensitive adhesive 40 and the drug cream 42 stored in the inside are pressurized at predetermined time intervals by the applicators 45 and 47, and the pressure-sensitive adhesive 40 and the drug cream 42 (coating liquid) are extruded by this pressure. Is. Here, the applicator 45 is controlled by the control means 36, and controls the pressure supply for uniform application of the adhesive 40 according to the signal from the control means 36. On the other hand, the applicator 47 is controlled by the control means 38, and in accordance with a signal from the control means 38, the control of the pressure supply for the uniform application of the drug cream 42 and the pressure supply for the intermittent application are performed. ON / OFF control is performed.

The die coating apparatus used in the present invention has the above-described characteristics, but the present invention is not limited to this, and various known types of die coating apparatuses for continuous coating and intermittent coating can be used. Are also available.
In particular, when the drug cream 42 is pushed out, the intermittent coating die coating apparatus 30 reliably cuts the end of the drug cream so as not to cause shape disturbance such as blurring, sagging, and stringing at the end of the coating section. It is particularly desirable that such a die coating apparatus is disclosed in Japanese Patent Laid-Open No. 2001-179156 (Patent Document 1) or Japanese Patent No. 2917127 (Patent Document 2), Japanese Patent Laid-Open No. 8-257464 (Patent Document 4). It is also possible to use what is disclosed in.

In addition, in the coating sheet processing apparatus 10 of the example of illustration, the 2nd for apply | coating the chemical cream 42 intermittently using the die-coating apparatus for continuous coating as a 1st coating apparatus for apply | coating the adhesive 40 continuously. Although the die coating apparatus for intermittent coating is used as the coating apparatus, the present invention is not limited to this, and various known coating apparatuses can be used as long as continuous coating of the adhesive 40 and intermittent coating of the chemical cream 42 can be performed. Is also available.
For example, a roll coater or a knife coater can be used as a coating device for continuous coating or intermittent coating.
In the coating sheet processing apparatus 10 shown in FIG. 1, the continuous application of the adhesive 40 is first performed on the base sheet 14, and then the intermittent application of the drug cream 42 is performed. If there is little deformation, coating control is very easy.

  As described above, the patch sheet 22 processed in the illustrated coating sheet processing apparatus 10 has the cover film 20 on the coated substrate sheet 15 as shown in FIGS. 3 (a) and 3 (b). Then, along the virtual cutting line indicated by the broken line in FIGS. 3 (a) and 3 (b), it is cut by a known patch sheet cutting device, and FIG. 4 (a) and ( The patch 50 having the form shown in b) can be produced. In addition, in the coating sheet processing apparatus 10 for manufacturing such a patch 50, after that, the patch sheet 22 formed in a wide and long strip shape is cut to manufacture individual patches 50. A patch sheet cutting device is arranged. However, the patch sheet cutting device that can be used in the present invention is not particularly limited, and various known patch sheet cutting devices can be used. For example, the combination of a slitter apparatus and a rotary cutter apparatus, the punching apparatus by die-roll or punching, etc. can be mentioned.

A patch 50 shown in FIGS. 4A and 4B uses a non-woven fabric or the like as the base sheet 14, and a support 52 such as a non-woven fabric and an adhesive layer formed on substantially the entire surface of the support 52. 41, and a drug cream layer 43 formed in a substantially 1/4 area, for example, on the substantially center of the pressure-sensitive adhesive layer 41, and the support 52, the pressure-sensitive adhesive layer 41, and the drug cream layer 43 are covered. It has a cover film 20 and has a four-layer structure.
Here, the patch 50 in FIG. 4A shows a state in which the cover film 20 serving as a release sheet is partially peeled off.

  In the above-described example, the support sheet 52 is formed using a nonwoven fabric or the like as the base sheet 14, and the adhesive 40 is continuously applied onto the support 52 such as a nonwoven fabric, and the drug cream 42 is intermittently applied thereon. Although the non-woven fabric used as the support 52 is very soft and easily stretches or deforms, the support such as a non-woven fabric that tends to be stretched or deformed is used in the present invention. It is not very suitable as a base sheet for performing double coating.

  Thus, when manufacturing the sticking agent which uses the support body which is very soft and stretches easily and deforms, like the coating sheet processing apparatus 60 shown in FIG. 5, that is, the coating sheet shown in FIG. Contrary to the processing apparatus 10, the drug cream 42 is intermittently applied on the cover film 20, and a drug cream layer 43 having a predetermined length is intermittently formed on the cover film 20 at a predetermined interval. The adhesive 40 is continuously applied thereon to continuously form the adhesive layer 41, and the base material sheet 14 made of a nonwoven fabric or the like is pasted on the adhesive layer 41 to obtain the patch sheet 22. be able to. The patch sheet 22 obtained in this way is the one in which the laminated structure of the patch 50 shown in FIG. 4B is turned upside down, but has exactly the same laminated structure.

  The coating sheet processing apparatus 60 shown in FIG. 5 replaces the arrangement of the base sheet supply apparatus 12 and the cover film supply apparatus 18 in the coating sheet processing apparatus 10 shown in FIG. The arrangement of the coating die coating device 28 and the backup roll 24 and the intermittent coating die coating device 30 and the backup roll 26 are interchanged, and the order of use of the base sheet 14 and the cover film 20 and the coating order are reversed. Since it is the same except for the fact that it is the same, description of individual components will be omitted, and a different operation, that is, a coating order will be mainly described.

In the coating sheet processing apparatus 60 shown in FIG. 5, the cover film 20 serving as a release sheet is supplied, and the cover film 20 unwound and supplied from the cover film supply apparatus 20 disposed at the left end in the figure is applied. Transport to device 17.
First, in the die coating device 30 for intermittent coating of the coating device 17, the cream-like medicine 42 is intermittently applied to the approximate center on the transported cover film 20, and the cover film 20. A drug cream layer 43 having a predetermined length is intermittently formed at predetermined intervals.
Next, in the die coating device 28 for intermittent coating of the coating device 17, the adhesive 40 is applied so as to cover the drug cream layer 43 on substantially the entire surface of the cover film 20 on which the drug cream layer 43 is intermittently formed. By continuously coating, the pressure-sensitive adhesive layer 41 is continuously formed, and the coated cover film 21 is manufactured.

Next, a base sheet such as a nonwoven fabric unwound from the base sheet supply device 12 on the surface of the pressure-sensitive adhesive layer 41 of the coated cover film 21 in the backup roll 24 and the coating roll 32 constituting the coating apparatus. 14 is stuck and the patch sheet | seat 22 which is a coating sheet is manufactured. The patch sheet 22 thus manufactured can be cut by a known cutting device to manufacture the patch 50 in the form shown in FIGS. 4 (a) and (b).
In the coating sheet processing apparatus 60 shown in FIG. 5, since the coating is performed on the cover film 20 with little elongation or deformation, intermittent coating of the drug cream 42 or continuous coating of the adhesive 40, particularly The coating thickness, coating length, and coating interval can be controlled with high accuracy.

Thus, in the coated sheet processing apparatuses 10 and 60 of the present invention shown in FIGS. 1 and 5, the patch 50 of the present invention shown in FIGS. 4 (a) and (b) can be produced.
Here, the support 52 used in the patch 50 shown in FIGS. 4 (a) and 4 (b) is not particularly limited, and a known support material generally used for a patch can be used. For example, paper rubber, cotton, cellulose, polyester, polyolefin, polypropylene, rayon, plastic, soft vinyl chloride, polyethylene, polyurethane or other sheet or film, or paper, rubber, cotton, cellulose, sufu, chemical fiber (polyester, polyolefin, Polypropylene, rayon), non-woven or woven fabrics such as plastic, or foam sheets such as soft vinyl chloride, polyethylene, and polyurethane.

The support 52 is preferably a stretchable elastic sheet that can be easily stretched and deformed. Examples of the support 52 include non-woven fabrics or woven fabrics of various materials described above, and foam sheets. Preferred are non-woven fabrics or woven fabrics of chemical fibers, and particularly preferred are those having high air permeability, specifically mesh-like or net-like packaging materials.
Depending on the application of the patch, there is a support that uses a support having little stretch and deformation and less stretchability as the support 52. In the case of such a use, the sheet | seat and film of the various materials mentioned above can be used as the support body 52, and the support body sheet | seat which consists of such a sheet | seat or film is the coating of this invention shown in FIG. The base sheet 14 can be used in the machine sheet processing apparatus 10.

Next, the pressure-sensitive adhesive 40 used for the patch 50 of the present invention is for forming a pressure-sensitive adhesive layer 41 on substantially the entire surface of the base sheet 4 to be a support sheet (support 52). This is for fixing the patch 50 by covering the affected area with the layer 43 and directly adhering to the skin at the part of the adhesive layer 41 where the drug cream layer 43 is not formed.
The pressure-sensitive adhesive 40 for forming such a pressure-sensitive adhesive layer 41 is not particularly limited as long as the pressure-sensitive adhesive necessary for the patch 50 is exhibited. It is preferable that the drug cream 42 has a sufficient adhesive force so that the drug cream 42 does not protrude from the periphery of the patch 50. For example, natural rubber, synthetic polyisoprene rubber, polystyrene / polybutadiene rubber, synthetic rubber such as styrene-isoprene-styrene block polymer pressure sensitive adhesive, acrylic pressure sensitive adhesive by a combination of various monomers including acrylic acid, acrylic acid ester, Examples include silicone resin-based pressure-sensitive adhesives composed of silicone and a tackifier resin, and preferably acrylic and synthetic rubber-based pressure-sensitive adhesives.

Next, the creamy drug (drug cream) 42 used in the patch 50 of the present invention is separated by a predetermined interval on the adhesive layer 41 on the base sheet 14 (support 52), and has a predetermined size (long). And width) for forming the drug cream layer 42 and covering the affected area.
The drug cream 42 for forming the drug cream layer 43 is not particularly limited, and any drug may be used as long as it is applied and applied to the affected area. Here, the drug cream in the present invention, that is, the cream-like drug, refers to a cream-like form as the form of the drug, but also includes an ointment, gel, lotion (liquid, suspension, etc.). ) And emulsions. In addition, examples of the base used in the drug cream include an aqueous base, an oil base, and an emulsion base. The drug cream 42 is preferably a so-called cream or ointment.
Furthermore, a medicine or dosage form with a lot of liquid components can be applied to the medicine cream 42 used in the patch 50 of the present invention. For example, the liquid component is a component that is in a liquid state at room temperature and can dissolve solid matter (solid), such as water, polyhydric alcohol, higher alcohol, fatty acid ester, mineral oil, surfactant, unsaturated fatty acid, etc. Can be mentioned. Further, the drug cream 42 may contain a water-soluble drug or may contain a fat-soluble drug, or may contain a mixture of these water-soluble drug and fat-soluble drug, It may be included separately.
In the patch 50 of the present invention, when the drug cream 42 contains only one of a water-soluble drug and a fat-soluble drug, the other may be included in the adhesive 40.

  Further, the drug and active ingredient contained in the drug cream layer 43, that is, the drug cream 42 for forming the drug cream layer 43 are not particularly limited, and any drug may be used for local or systemic percutaneous absorption. It can be anything. For example, in anticipation of a sustained effect, analgesics, antipruritics, astringents, antiphlogistics, purulent diseases, burns, parasitic skin diseases (eg athlete's foot treatment) Etc.), antitumor antibiotics, trauma treatment or wound treatment, local treatment such as bed sores, and vasodilators, angina treatment agents, hormone preparations, antipyretic analgesic / antiinflammatory agents, hypertensive agents, cardiovascular agents, etc. And systemic therapeutic agents. Preferred examples include corticosteroids, sulfa drugs, anticancer drugs, anti-inflammatory analgesics, antibiotics, physiologically active substances, vitamins, preferably salicylic acid, heparin-like substances, and adrenal extracts.

In addition, the content of the drug in the drug cream 42 or the drug cream layer 43 is not particularly limited, and a known content can be applied and can be variously changed depending on the type of drug, application, symptom, and the like. it can.
Further, the size (length, width, thickness) of the drug cream layer 43 in the patch 50 or the coating amount of the drug cream 42 is not particularly limited, and is publicly known depending on the type of drug, application, symptom, and the like. The content can be applied and can be variously changed.

Next, the cover film 20 used for the patch 50 of the present invention includes the adhesive cream layer 42 intermittently formed on the adhesive layer 41 on the base sheet 14, and includes the adhesive layer 41 and the base material. The sheet 14 is covered and protected, and when the patch 50 is used, a peeling sheet is applied to fix the patch 50 by applying the drug cream layer 42 to the affected area and adhering it to the surrounding skin with the adhesive layer 41. It has the function of. In particular, the cover film 20 prevents contamination as a pharmaceutical product and prevents quality change and destabilization due to the drug cream layer 43 coming into contact with external air and drying the drug, and protects the adhesive surface of the adhesive layer 41. Is to do.
As the cover film 20, various known cover films that are usually used for patches can be used as long as the drug cream layer 42 is well protected and its properties are not altered by the drug cream. For example, film-like, sheet-like, and fixed-shaped molded products widely used as release sheets (liners) such as patches and poultices can be used, but they are peeled off due to the form and type of the drug. At this time, it is preferable to select one having a small amount of drug remaining on the cover film 20.

Examples of the material of the cover film 20 include paper (for example, glassine paper), a paper obtained by laminating or coating a separating agent such as silicon, polyolefin such as polyethylene and polypropylene, polyester such as polyethylene terephthalate, nylon, and cellophane. , Polystyrene, polyvinylidene chloride, polyvinyl chloride, aluminum film, or a multilayer film (laminate) thereof. Further, in order to suppress adhesion of the cover film of the drug cream 42 (drug cream layer 43) or the adhesive 40 (adhesive layer 41), at least the contact surface with the drug cream layer 43 or the adhesive layer 41 is made of a silicone resin or the like. A release liner coated with can also be used.
In addition, the thickness and size of the cover film 20 are not particularly limited, and may be the thickness and size that are usually applied to patches.
The cover film 20 is approximately the same size as the base sheet 14, and is sandwiched between the pressure-sensitive adhesive layer 41 and the drug cream layer 43 so as to be covered and fixed to the base sheet 14.

  The fixing method of the cover film 20 to the base sheet 14 is not particularly limited, and various known fixing methods can be applied as long as they are fixing methods that are usually used for patches. For example, it is not particularly limited as long as it can be peeled off from the base material sheet 14 laminated with the drug cream layer 43 at the time of use. A method of fusing or caulking can be used alone or in combination. Preferably, in addition to bonding through the adhesive surface of the base material sheet 14, immobilization by a sealing method is performed. The sealing method broadly means a fixing method or an adhesion method.

  In the case of producing a patch using such a support that is very soft and easily stretches and deforms, the base sheet of the coated base sheet 15 shown in FIGS. 3 (a) and 3 (b) 14, using a base fill that is not easily stretched or deformed, and after covering the cover film 20, a support 52 such as a non-woven fabric is pasted on the non-coated surface of the base sheet 14 that becomes the base film. good.

An example of such a patch is shown in FIG.
The patch 51 shown in the figure is formed by laminating a support 52 such as a nonwoven fabric, a base film 54 made of a base sheet 14, an adhesive layer 41, a drug cream layer 43, and a cover film 20 in this order. However, since the patch 50 and the base film 54 shown in FIG.
Here, the material of the base film 54 to be used is not particularly limited, but usually polyolefins such as polyethylene and polypropylene, polyester, nylon, polyvinyl alcohol, polystyrene, aluminum film, polyvinylidene chloride and the like, or a multilayer film (laminate) thereof. Further, those processed with silicon are preferably a multilayer film made of polyethylene and polyester, and a polyolefin film.

Such a patch 51 can be manufactured by the coating sheet processing apparatus 70 shown in FIG.
The coating sheet processing apparatus 70 shown in FIG. 7 includes the support sheet supply apparatus 52 and the application roll 58 in the coating sheet processing apparatus 10 shown in FIG. The same components are denoted by the same reference numerals, description thereof is omitted, and differences are mainly described.

  In a coating sheet processing apparatus 70 shown in FIG. 7, a support sheet supply apparatus 52 that supplies a support sheet 52 from a support sheet roll 52a or 52b is disposed at the left end in the figure, and a base film 54 is formed inside thereof. A base material sheet supply device 12 for supplying the base material sheet 14 is arranged, and as a coating device for the coating device 16, a cover film is provided on the downstream side of the coating roll 32 and further on the coated base material sheet 15 by the coating roll 32. The support supplied from the support sheet supply device 52 to the base sheet 14 of the covering sheet 23 transported by the transporting roll 56 between the transporting roll 56 transporting the covering sheet 23 produced by coating 20. A coating sheet that includes a pasting roll 58 for pasting the body sheet 52, and the base sheet 14 of the covering sheet 23 is pasted on the support sheet 52. And it forms a that patch sheet 72.

Here, the covering sheet 23 has the same configuration as the patch sheet 22 whose base is the base sheet 14 made of the support 52 except that the base is the base sheet 14 made of the base film 54. It is.
The patch sheet 72 thus obtained is cut by a known cutting device to produce the patch 51 shown in FIG.

In each of the above-described embodiments, the first coating liquid to be coated on the base sheet 14 is the pressure-sensitive adhesive 40, and the first coating layer on the base sheet 14 is the pressure-sensitive adhesive layer 41. The second coating liquid applied on the layer (adhesive layer 41) is the drug cream 42, and the second coating layer on the first coating layer is the drug cream layer 43. However, the present invention is not limited to this. The first coating layer may be a drug-containing pressure-sensitive adhesive layer 41 and the second coating layer may be a drug layer containing different drugs, and the first and second coating layers may include a drug. The coating layer may be a drug layer containing different drugs, for example, one of them may be a drug layer containing a water-soluble drug, and the other may be a drug layer containing a fat-soluble drug. At this time, of course, the first coating layer may be a layer containing the pressure-sensitive adhesive 40 and one of the water-soluble drug-containing drug and the fat-soluble drug-containing drug, and the second coating layer may be the other drug layer.
Further, a third coating layer may be provided, and the first coating layer may be a pressure-sensitive adhesive layer 41, and the second and third coating layers may be drug layers containing different drugs. For example, one of them may be a water-soluble drug layer, The other side may be a fat-soluble drug-containing drug layer, the drug cream layer 43 on the pressure-sensitive adhesive layer 41 is composed of two layers, one of which is a water-soluble drug-containing drug layer, and the other is a fat-soluble drug-containing drug layer. Also good. In this case, of course, the third coating device is necessary.

  Moreover, in each Example mentioned above, as the base material sheet 14 used as the support body 52 or the base film 54, or the support body sheet 52, the long base material sheet 14 or the support body sheet 52 wound in a roll shape, that is, Although the long base sheet rolls 14a and 14b and the long support sheet rolls 52a and 52b are used, the present invention is not limited to this, and a foldable long base material such as a lint cloth is used. A sheet or a foldable long support sheet may be used.

  As mentioned above, although the coating sheet processing apparatus concerning this invention and the patch manufactured using this were mentioned and demonstrated with various Examples, this invention is not limited to these Examples, It goes without saying that various improvements and changes can be made without departing from the spirit of the invention.

DESCRIPTION OF SYMBOLS 10 Coating sheet processing apparatus 12 Base material sheet supply apparatus 14 Non-woven fabric 15 Coated base sheet 16 Coating apparatus 18 Cover film supply apparatus 20 Cover film 22 Patch sheet 24, 26 Backup roll 28, 30 Die coating apparatus 32 Coating roll 34 Belt conveying device 36, 38 Control means 39 Sensor 40 Adhesive 41 Adhesive layer 42 Creamy drug (drug cream)
43 Drug cream layer 44, 46 Die 45, 47 Applicator

Claims (4)

A first sheet supply device that holds a long first sheet and pulls out and supplies the first sheet;
A second sheet supply device for holding a long second sheet and pulling out and supplying the second sheet;
A first coating device that forms a first coating layer by applying a first coating on the first sheet;
A second coating layer is continuously disposed in the first coating device, and a second coating layer is formed by applying a second coating material on the first coating layer on the first sheet. Coating equipment;
A coating apparatus for forming a coating sheet by coating the second coating layer coated on the first coating layer with the second sheet;
When the first sheet is a roll-shaped long base sheet and the second sheet is a roll-shaped long cover film,
The first coating device is a continuous coating device that continuously applies the first coated material, and the second coating device intermittently applies the second coated material. Intermittent coating equipment,
When the first sheet is a roll-like long cover film and the second sheet is a roll-like long base sheet,
The first coating device is an intermittent coating device that intermittently applies the first coated material, and the second coating device continuously applies the second coated material. A coating sheet processing apparatus, which is a continuous coating apparatus. A first sheet supply device that holds a long base film and draws and supplies the base film;
A second sheet supply device that holds a long cover film and pulls out and supplies the cover film;
A support sheet supply device that holds a long base sheet and pulls out and supplies the equipment sheet;
A first coating device that forms a first coating layer by applying a first coating on the base film;
A second coating is disposed continuously in the first coating device, and a second coating layer is formed by coating a second coating layer on the first coating layer on the base film. Construction equipment,
A coating apparatus that coats the second coating layer coated on the first coating layer with the second sheet to form a coating sheet;
In the coating sheet, having a pasting roll for pasting the support sheet on the surface opposite to the first coating layer of the base film,
The first coating device is a continuous coating device that continuously applies the first coated material, and the second coating device intermittently applies the second coated material. A coating sheet processing device that is an intermittent coating device. The coating sheet is a patch sheet,
The base sheet is a support sheet made of a nonwoven fabric or a woven fabric,
The coated material applied by the continuous coating device is an adhesive, and the coated material coated by the intermittent coating device is a creamy medicine. 2. The coating sheet processing apparatus according to 2. A sensor that detects the front and rear ends of the coated material coated by the intermittent coating device on the downstream side of the intermittent coating device along the conveyance direction of the first sheet,
In the case where the coating length and the coating interval of the coated material coated by the intermittent coating device are equal,
The sensor is disposed at a position away from the position of the discharge port of the intermittent coating apparatus by a coating length along the conveyance direction of the first sheet,
When the sensor detects the front end portion of the coated material applied by the intermittent coating device, the application by the intermittent coating device is stopped, and the sensor is applied by the intermittent coating device. The coating sheet processing apparatus according to any one of claims 1 to 3, wherein when the rear end portion of the workpiece is detected, coating by the intermittent coating apparatus is started.

Images