JP2009114197A - Anti-fatigue agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an anti-fatigue agent using xanthoangelol and 4-hydroxyderricin as active ingredients, although the xanthoangelol and 4-hydroxyderricin are known to have functions such as an HMG-CoA reductase inhibitory effect, inflammatory cytokine production inhibitory effect, adiponectin production enhancing effect, etc., they are also useful for reducing fatigue other than those shown above. <P>SOLUTION: This anti-fatigue agent using the xanthoangelol and/or 4-hydroxyderricin as the active ingredients is provided. Further, the fatigue in this invention is a phenomenon of decreasing a certain function as a result of exhibiting the function. As the anti-fatigue effect in the invention, there are effects of reducing such the fatigue state, recovering the fatigue state, preventing the fatigue state, etc. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to an anti-fatigue agent containing xanthoangelol and / or 4-hydroxyderricin as an active ingredient.

Xanthoangelol and 4-hydroxyderricin have known functions such as HMG-CoA reductase inhibitory action (Patent Document 1), inflammatory cytokine production inhibitory action (Patent Document 2), and adiponectin production enhancing action (Patent Document 3). It has been.
However, it is not known that xanthoangelol and / or 4-hydroxyderricin has the anti-fatigue action described below.
International Publication WO2005 / 074906 Pamphlet JP 2008-106011 A JP 2007-262050 A

  An object of the present invention is to provide an anti-fatigue agent having an excellent anti-fatigue action.

  The present invention provides an anti-fatigue agent comprising xanthoangelol and / or 4-hydroxyderricin as an active ingredient.

ADVANTAGE OF THE INVENTION According to this invention, the anti-fatigue agent which has the outstanding anti-fatigue action can be provided. In addition, the fatigue in this invention means the phenomenon in which the function falls as a result of exhibiting a certain function. For example, “physical fatigue after swimming”, “mental fatigue after prolonged intellectual work”, “combined physical and mental fatigue that accumulates in everyday life”, etc. it can.
The anti-fatigue effect (nutrient tonic effect) referred to in the present invention includes an action of reducing the fatigue state as described above, an action of recovering the fatigue state, or an action of preventing the fatigue state.

  Hereinafter, the present invention will be described in more detail.

  Xanthoangelol and / or 4-hydroxyderricin used in the present invention are commercially available, and can also be synthesized according to known methods. Apart from this, xanthoangelol and / or 4-hydroxyderricin can also be obtained by extracting from acetaceae of the Apiaceae plant, fractionating by various chromatography, etc., and purifying. In addition, the said method is well-known, For example, it is disclosed by the said patent documents 1-3.

  The dose of xanthoangelol and / or 4-hydroxyderricin varies depending on the patient's age, body weight, indication symptoms, etc., for example, about 1 mg to 10 g per day, preferably about 1 mg to 10 g per day, preferably It is better to administer about 10 mg to 1 g.

  The anti-fatigue agent of the present invention can be appropriately prepared by a known method in the form of a solid or solution (hereinafter also referred to as a preparation) such as tablets, pills, capsules, granules, powders, powders, and liquids. That is, the solid preparation or liquid preparation useful in the present invention is produced by using a well-known preparation method that has been well established. Examples of additives include excipients, pH adjusting agents, cooling agents, suspending agents, diluents, antifoaming agents, thickeners, solubilizers, disintegrating agents, binders, lubricants, antioxidants. Agents, coating agents, coloring agents, flavoring agents, surfactants, plasticizers or fragrances.

  The anti-fatigue agent of the present invention can be taken as various health foods and functional foods. Examples of these include various products, but for the production of health foods and functional foods, in addition to commonly used food materials and food additives, excipients, extenders, binders, It can be used in the form of food and drink preparations using adjuvants such as disintegrants, lubricants, dispersants, preservatives, wetting agents, solubilizers, preservatives, stabilizers, capsule bases and the like. Specific examples of the adjuvant include lactose, fructose, glucose, starch, gelatin, magnesium carbonate, synthetic magnesium silicate, talc, magnesium stearate, calcium carbonate, methylcellulose, carboxymethylcellulose, or a salt thereof, gum arabic , Polyethylene glycol, syrup, petrolatum, glycerin, ethanol, propylene glycol, citric acid, sodium chloride, sodium sulfite, sodium phosphate, pullulan, carrageenan, dextrin, reduced palatinose, sorbitol, xylitol, stevia, synthetic sweetener, citric acid Ascorbic acid, acidulant, baking soda, sucrose ester, hardened vegetable oil, potassium chloride, safflower oil, beeswax, soybean lecithin, flavor, and the like can be blended. Regarding the production of such health foods and functional foods, reference books for pharmaceutical preparations such as “Japanese Pharmacopoeia Manual (General Rules for Preparations)” (Yodogawa Shoten) can be referred to.

  In addition to the above, the anti-fatigue agent of the present invention can be taken as a food or drink. Specifically, natto, thick fried, tofu, konjac, dumplings, pickles, boiled, croquettes, sandwiches, pizzas, hamburgers, dumplings, shumai, salads, etc., various powders (beef, pork, chicken and other livestock products) Marine products such as shrimp, scallops, sea bream, kelp, vegetables / fruits, plants, yeast, algae, etc.), pudding, cookies, crackers, bread, cakes, chocolate, potato chips, biscuits, donuts, jellies and other confectionery, Japanese rice crackers such as rice crackers, sheep crab, daifuku, ohagi, other buns, Japanese confectionery such as castella, frozen confectionery (rice cake etc.), bread and confectionery such as chewing gum, noodles such as udon, buckwheat and kishimen, kamaboko, ham, fish sausage, etc. Fish paste products, meat products such as ham, sausage, hamburger, corn beef, salt, pepper, miso, soy sauce, sauce, dressy Seasonings such as gyu, mayonnaise, ketchup, sweeteners, spices, teppanyaki foods such as Akashi-yaki, takoyaki, monja-yaki, okonomiyaki, yakisoba, fried udon, dairy products such as cheese, hard-type yogurt, and fats and oils Various foods such as powdered solids of flavors and fragrances (vanilla, citrus fruits, bonito etc.) and powdered foods and drinks (instant coffee, instant tea, instant milk, instant soup, miso soup, etc.) These are not particularly limited.

  Furthermore, in the present invention, for example, royal jelly, propolis, vitamins (A, C, D, E, K, folic acid, pantothenic acid, biotin, derivatives thereof, etc.), minerals (iron, magnesium, calcium, zinc, etc.), Selenium, lecithin, carotenoids (lycopene, astaxanthin, zeaxanthin, lutein, etc.), saponins (gymnemic acid, soybean saponin, ginseng saponins, etc.), fatty acids, proteins (collagen, elastin, etc.), oligosaccharides (isomalto-oligosaccharides, cyclic oligosaccharides, etc.) ), Phospholipids and derivatives thereof (phosphatidylcholine, sphingomyelin, ceramide, etc.), sulfur-containing compounds (eg, alliin, sepaene, taurine, glutathione, methylsulfonylmethane), sugar alcohols, lignans (sesamin, etc.), Contains animal and plant extracts Root vegetables (turmeric, ginger, etc.), may be used in combination and the like.

  EXAMPLES Hereinafter, although an Example demonstrates this invention further, this invention is not limited to these.

Example 1
STD DDY male mice (5 weeks old: each group n = 3 to 4) were orally ingested with xanthoangelol powder (hereinafter referred to as powder 1). The intake is 10 mg / kg body weight. Ingestion was performed using a solution in which powder 1 was dissolved in pure water. In addition, the test group mice were fed with pure water only.

Thirty minutes after the ingestion, the mouse was placed in an 80 cm deep water tank, and the time until immobility was measured. As an average value of time until mice of each test group (n = 3 to 4) reached immobility, the control group was about 100 seconds, while the powder 1 administration group was about 390 seconds. there were.
From the above, it was confirmed that the powder 1 has a high anti-fatigue effect.

Example 2
Twelve volunteer men (age 34-37) were grouped into a test meal group (Example) and a placebo group (Comparative Example). The test meal group (Example) is a group in which the powder 1 is processed into a soft capsule based on olive oil and 100 mg of the powder 1 is ingested every day. The placebo group (comparative example) is a group in which soft capsules containing olive oil without powder 1 are ingested daily.
Volunteer men were exercised with a bicycle ergometer at 5 and 9 weeks after ingestion. The exercise continues for 30 minutes at an exercise intensity of 80% load of the maximum heart rate.
The blood lactate levels of volunteer men immediately before and after exercise were measured with a commercially available simple blood lactate analyzer, and the amount of blood lactate increased was examined.
As a result, the increase after 5 weeks from the start of ingestion was about 6 mmol / l in the comparative example, whereas it was about 5.3 mmol / l in the example.
The increase after 9 weeks from the start of ingestion was about 6 mmol / l in the comparative example, whereas it was about 4.6 mmol / l in the example.
From the above, the anti-fatigue action of the powder 1 was clarified.

  In addition, it replaced with said xanthoangelol, and when the same experiment as the above was conducted using 4-hydroxy derricin, the substantially same result was obtained.

The compounding example of the anti-fatigue agent of this invention is shown below.
Candy sugar 50.0wt%
Minamata 33.0
Water 14.4
Organic acid 2.0
Fragrance 0.2
Anti-fatigue agent of the present invention Total remaining amount 100.0 wt%

Yogurt milk 41.5wt%
Nonfat dry milk 5.8
Sugar 8.0
Agar 0.15
Gelatin 0.1
Lactic acid bacteria 0.005
Anti-fatigue agent of the present invention 0.4
Perfume Trace water Residue
Total 100.0wt%

Soft drink fructose glucose liquid sugar 30.0wt%
Emulsifier 0.5
Anti-fatigue agent of the present invention 0.3
Perfume Appropriate amount of water Residual
Total 100.0wt%

Claims (1)

  An anti-fatigue agent containing xanthoangelol and / or 4-hydroxyderricin as an active ingredient.