JP2009082631A - Biosensor measuring instrument - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a biosensor measuring instrument enhancing the percentage of success of puncturing and collection by preventing the failure at the time of collection of a sample. <P>SOLUTION: The biosensor measuring instrument 10 is loaded with a biosensor cartridge 14 integrally provided with a puncture implement for puncturing a subject and a biosensor chip 41 for collecting the sample obtained by puncturing the subject to measure the biosubstance in the collected sample, and equipped with a measuring instrument main body 13, a freely openable and closable collection mechanism housing part 11 connected to the measuring instrument main body 13 by a hinge, a vacuum mechanism-housing chamber 27 formed in the collection mechanism-housing part 11 to house a vacuum mechanism 30, and a vacuum airtight chamber 28 formed in the collection mechanism-housing part 11 to be allowed to communicate with the vacuum mechanism 30. The vacuum airtight chamber 28 is loaded with the biosensor cartridge 14 and houses a puncture mechanism 25 for subjecting the biosensor cartridge 14 to the puncture operation of the subject. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a biosensor measurement device that loads a biosensor cartridge having a puncture device, punctures a subject with the puncture device, collects a sample, and measures, and particularly relates to a technique for improving a reduced pressure state during collection. .

  As an example of a biosensor measurement device, a lancet holder that has a lancet and moves from a standby position to a puncture position, a contact portion that comes into contact with a subject, and a decompressed space that is depressurized to apply a suction force to the lancet holder Is known, and the pressure in the decompression space is made lower than the atmospheric pressure to facilitate the backward movement of the lancet holder (see, for example, Patent Document 1).

The biosensor measuring device disclosed in Patent Document 1 engages the engaging claw of the lancet holder with the upper surface of the expansion portion of the housing, and then drives the electric pump to depressurize the air in the decompression space. After the lancet is mounted on the lancet holder and the contact portion is brought into close contact with the subject, the electric pump is driven to generate a negative pressure in the contact portion, and the operation cap is pushed down to pierce the lancet into the subject.
International Publication No. 2004/082478 Pamphlet (Figure 1)

  However, in the biosensor measurement device disclosed in Patent Document 1, the operation of driving the electric pump to depressurize the air in the decompression space and the negative pressure in the contact portion after the contact portion is brought into close contact with the subject. Since it is necessary to drive the electric pump twice in total to generate it, it is difficult to generate reduced pressure and negative pressure, causing problems such as outgassing during the puncturing operation and collecting samples. There was a risk of failure.

  Accordingly, the present invention has been made in view of the above-described circumstances, and an object of the present invention is to provide a biosensor measurement device that can prevent a failure during sample collection and improve the success rate of puncture and collection. is there.

In order to achieve the above-mentioned object, the first feature of the biosensor measurement device according to the present invention is:
A biosensor cartridge in which a puncture device for puncturing a subject and a biosensor chip for collecting a sample obtained by puncturing the subject is loaded, and a living body in the collected sample A biosensor measurement device for measuring a substance,
A measuring device main body, a sampling mechanism storage unit, a decompression mechanism storage chamber formed in the sampling mechanism storage unit and storing a decompression mechanism, and a decompression airtight chamber formed in the sampling mechanism storage unit and communicated with the decompression mechanism And a housing portion for loading the biosensor cartridge is provided in the vacuum hermetic chamber.
In the present invention, a needle, a lancet needle, a cannula and the like are referred to as a puncture device.

In the biosensor measurement apparatus configured as described above,
When the decompression mechanism is driven, the decompression airtight chamber which is a single space communicated with the decompression mechanism is decompressed, and the puncture mechanism housed in the decompression airtight chamber is operated to puncture the biosensor cartridge. Is punctured into the subject, and the sample is collected and the biological material in the sample is measured. Thereby, since the decompression mechanism is driven only a single number of times, it is possible to prevent a failure at the time of sample collection and improve the success rate of puncture and collection.

  Further, a second feature of the biosensor measurement device according to the present invention is the biosensor measurement device according to the first feature, wherein the reduced-pressure airtight chamber has an opening that contacts the subject. A first stage where the opening contacts the subject and the decompression mechanism is driven; and after the decompression mechanism is driven, the puncture instrument of the biosensor cartridge is punctured into the subject. The reduced pressure state can be maintained through two stages.

  In the biosensor measurement apparatus configured as described above, the biosensor is activated when the decompression mechanism is driven in the first stage and when the decompression mechanism is driven in the second stage and after the decompression mechanism is driven in the second stage. When the puncturing device of the cartridge is punctured into the subject, the decompressed state of the decompressed airtight chamber is maintained. This eliminates the need to drive the decompression mechanism multiple times while still in contact with the subject, facilitating the handling of the user, preventing failure during sample collection, and the success rate of puncture and collection Can be improved.

  Further, a third feature of the biosensor measurement device according to the present invention is the biosensor measurement device according to the first or second feature, wherein the measurement device main body defining the decompression airtight chamber and the sampling The sealing member which maintains airtightness is interposed in the contact surface with the mechanism housing portion.

  In the biosensor measuring apparatus configured as described above, since the sealing member that maintains airtightness is interposed on the contact surface between the measuring apparatus main body and the sampling mechanism housing portion, it is possible to reliably ensure the airtightness in the decompression airtight chamber. it can.

  Further, a fourth feature of the biosensor measurement device according to the present invention is the biosensor measurement device according to any one of the first to third features, wherein the collection mechanism storage portion is interposed via a hinge member. It is connected to the measuring device body so as to be freely opened and closed.

  In the biosensor measurement apparatus configured as described above, since the collection mechanism storage unit and the measurement apparatus main body are connected by a hinge member, the opening / closing operation of the measurement apparatus main body can be performed smoothly.

  Further, a fifth feature of the biosensor measurement device according to the present invention is the biosensor measurement device according to any one of the first to fourth features, wherein a biasing spring is interposed in the decompression airtight chamber. A pressing member for loading the biosensor cartridge, a sliding pin movably attached to the pressing member, and the sliding pin rotatably connected to the measurement apparatus main body. A rod with a cylinder, and a lock arm connected to the puncture button and rotatably supported, and the pressing member is urged through the rod with the cylinder by opening the measuring device main body. When the biosensor cartridge is loaded, the measuring device main body is closed and the puncture button is pressed down to move the engagement of the pressing member. State is canceled, the pressing member together with the biosensor cartridge is to move to the puncturing position by the repulsive force of the biasing spring.

  In the biosensor measurement device configured as described above, when the measurement device main body is opened, the pressing member moves against the biasing spring, so that the storage portion that is the storage space for loading the biosensor cartridge is automatically set. Secured. In addition, when the measurement device main body is closed, the biosensor cartridge loaded at the tip of the pressing member is automatically moved to the puncture position by the repulsive force of the urging spring only by depressing the puncture button, to the subject. Puncture and sampling can be performed easily and reliably.

  According to the biosensor measurement apparatus of the present invention, it is possible to provide a biosensor measurement apparatus that can prevent failure during sample collection and improve the success rate of puncture and collection.

  Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings.

  1 to 9 show an embodiment of a biosensor measuring apparatus according to the present invention, FIG. 1 is an external perspective view of the biosensor measuring apparatus according to an embodiment of the present invention, and FIG. 3 is a bottom view of the sensor measuring device, FIG. 3 is an external perspective view of the biosensor measuring device in FIG. 1 with the measuring device main body opened, and FIG. 4 is an exploded view of the main part of the biosensor cartridge used in the biosensor measuring device in FIG. FIG. 5 is a longitudinal sectional view of the biosensor cartridge of FIG.

FIG. 6 is a longitudinal sectional view around the vacuum hermetic chamber before loading the biosensor cartridge for explaining the measurement operation of the biosensor measurement device of FIG. 1, and FIG. 7 is for explaining the measurement operation of the biosensor measurement device of FIG. FIG. 8 is a longitudinal cross-sectional view around the decompression airtight chamber after loading the biosensor cartridge, FIG. 8 is a longitudinal cross-sectional view around the decompression airtight chamber in the first stage for explaining the measurement operation of the biosensor measurement apparatus of FIG. It is a longitudinal cross-sectional view around the decompression | air_tightness airtight chamber in the 2nd step explaining the measurement operation | movement of 1 biosensor measuring device.
The embodiment disclosed this time should be considered as illustrative in all points and not restrictive. The scope of the present invention is defined by the terms of the claims, rather than the meanings described above, and is intended to include any modifications within the scope and meaning equivalent to the terms of the claims.

  As shown in FIGS. 1 and 2, a biosensor measurement device 10 includes a collection mechanism storage unit 11, and a measurement device main body 13 that is connected to the collection mechanism storage unit 11 through hinge members 12 and 12 so as to be freely opened and closed. The biosensor cartridge 14 is housed in the collection mechanism housing portion 11.

  The measuring device main body 13 functions as a lid member for the collection mechanism storage unit 11 and is provided with operation buttons 15 and 16 and a display unit 17 on the front surface. Since the operation buttons 15 and 16 are electrically connected to the measurement circuit unit 18 and the control circuit unit 19 built in the measurement apparatus main body 12, for example, one of the operation buttons 15 and 16 is pressed. As a result, the cumulatively stored result history is sequentially displayed on the display unit 17 in the past or sequentially closer to the present.

  The measurement circuit unit 18 performs an arithmetic process on the detection signal (voltage level or current level) obtained by the biosensor cartridge 14, and converts the biological material of the collected sample into an electrical signal based on the detection signal.

  The control circuit unit 19 sends a control signal corresponding to the measurement operation of the measurement circuit unit 18 and the on / off signals from the operation buttons 15 and 16 to the measurement circuit unit 18.

  The display unit 17 displays measurement results and measurement result histories obtained by the measurement circuit unit 18 through display control by the control circuit unit 19.

  A puncture assisting member 20 for indicating a puncture site to a user is attached to the lower surface of the collection mechanism storage unit 11, and an opening 21 faces the inside of the puncture assisting member 20. It is formed through. An annular seal member 22 is attached to the contact side of the puncture assisting member 20 with the subject.

  A pump operation button 23 and a puncture button 24 are provided on the upper surface of the collection mechanism storage unit 11 so as to be freely pressed. The pump operation button 23 is electrically connected to the control circuit unit 19 through, for example, a micro switch or a position switch. The puncture button 24 is mechanically connected to an arm 26 provided in a puncture mechanism (shown in FIG. 6) 25.

  As shown in FIG. 3, in the collection mechanism storage unit 11, a decompression mechanism storage chamber 27 and a decompression airtight chamber 28 that are opened upward are formed independently via a partition plate 29.

  The decompression mechanism storage chamber 27 houses a negative pressure pump 30 that is a decompression mechanism. The negative pressure pump 30 is connected in communication with the reduced pressure airtight chamber 28 through a negative pressure passage 31 incorporating a check valve (not shown). The negative pressure passage 31 is attached to the partition plate 29 while being kept airtight.

  Since the negative pressure pump 30 is electrically connected to the control circuit unit 19, the negative pressure pump 30 is driven when the pump operation button 23 is pressed in the airtight holding state of the decompression airtight chamber 28, and the gas in the decompression airtight chamber 28 is discharged. Reduce pressure.

  The decompression and airtight chamber 28 accommodates a pressing member 32 that constitutes the puncture mechanism 25, an urging spring 33, and a lock arm (see FIG. 6), and the biosensor cartridge 14 can be loaded therein. .

  The pressing member 32 is incorporated through a biasing spring 33 so as to be movable in the length direction of the decompression hermetic chamber 28, and a sliding pin 35 movably attached to the side long hole 34 is provided around the pin axis. Is pivotably engaged. The sliding pin 35 is rotatably connected to a support portion 38 of the measuring apparatus main body 13 through a rod 36 and a cylinder 37. At this time, the rod 36 and the cylinder 37 are fixed so that there is no change in the total length, but the total length may be variable.

  When the measuring device body 23 is opened, the pressing member 32 is moved in a direction away from the opening 21 which is a direction for compressing the biasing spring 33 via the rod 36 and the cylinder 37, and the moved pressing member 32 is moved. Between the member 32 and the opening 21, a cartridge loading portion 39 that is a housing portion for loading the biosensor cartridge 14 is formed.

  On the other hand, in the pressing member 32, when the measuring apparatus main body 23 is closed, the sliding pin 35 moves in the elongated hole 34 to the opening 21 side. The movement amount of the sliding pin 35 in the long hole 34 is set to be equivalent to the movement stroke of the biosensor cartridge 14.

  Further, the pressing member 32 has a terminal connector portion (shown in FIG. 6) 40 at the end on the opening 21 side. The terminal connector 40 accommodates terminals (not shown) that are electrically connected to a pair of detection terminals 42 and 43 included in a biosensor chip (shown in FIG. 4) 41 provided in the biosensor cartridge 14. These terminals are electrically connected to the electric wire 44. Since the electric wire 44 is disposed in the reduced pressure hermetic chamber 28, the electric wire 44 is kept airtight through a grommet 45 penetratingly assembled to the partition plate 29 and pulled out into the depressurization mechanism storage chamber 27. And is electrically connected to the measurement circuit unit 18.

  An airtight holding seal member 46 is attached to the entire upper surface of the open side of the reduced pressure hermetic chamber 28, and the reduced pressure hermetic chamber 28 is closed by the sampling mechanism storage unit 11. Thus, it is sealed except for the opening 21.

  As shown in FIGS. 4 and 5, the biosensor cartridge 14 includes an upper body 48, a biosensor chip 41, a lower body 49, an upper cover 50, a lower cover 51, and a puncture instrument 47. The cartridge side elastic member 52 is integrally formed.

  The biosensor chip 41 includes a first substrate 53, a second substrate 54, and a spacer 55, and a pair of detection terminals 42 and 43 are mounted on the lower surface of the first substrate 53. . Among these, one detection terminal 42 has a tip contact portion 56 formed in an L shape, and the other detection terminal 43 has a tip contact portion 57 similar to the one detection terminal 42. Are formed in an L-shape, and both contact portions 56 and 57 are arranged at the tip of the first substrate 53 with a predetermined gap in the plate direction of the first substrate 53.

  A reagent (not shown) that reacts with the sample is disposed between or in the vicinity of the contact portions 56 and 57. Examples of the reagent include a reagent that immobilizes an enzyme and a mediator and reacts with blood dalcose to generate an electric current. As a result, a sample such as blood collected from the sample collection port undergoes a biochemical reaction with the reagent.

  Under the first substrate 53, a second substrate 54 is laminated integrally with a spacer 55 made of an insulating layer and an adhesive layer, and the tapered shape of the first substrate 53 and the second substrate 54 is formed. A hollow reaction portion (not shown) is formed in the plate direction of the spacer 55 at the front end portion, and is cut out in a rectangular shape toward the rear end portion. In this hollow reaction part, the tip part is a sampling port, and the contact parts 56 and 57 of both terminals 42 and 43 are exposed, respectively.

  On the rear end side of the hollow reaction part, an air conduction path (not shown) arranged orthogonally to the hollow reaction part is formed, and the air conduction path has an open air opening part at both end parts open to the outside air. Yes. The air conduction path is formed so as to penetrate through the left and right sides of the biosensor chip 41, and is arranged so that the shape combined with the hollow reaction part is a T-shape. In the hollow reaction part, a surfactant is applied to the inner wall.

  The lower body 49 is formed with a communication channel 58 having a concave groove shape from one lower end to the other end of the puncture device 47 of the upper body 48.

  The cartridge-side elastic member 52 is formed in a shape having a sealed space that covers the periphery of the puncture instrument 47 using a flexible elastic member. The material of the elastic member 52 is not particularly limited as long as it has elasticity, but rubber or sponge made of a single polymer or copolymerized polymer such as silicone, urethane, acrylic, ethylene, styrene, polyethylene, polypropylene, and the like Polyolefin, polyethylene polyester such as polyethylene terephthalate and polybutylene terephthalate, etc., fluorine resin such as polytetrafluoroethylene and PFA which is a copolymer of perfluoroalkoxyethylene and polyfluoroethylene, and the like can be used.

  In the biosensor cartridge 14, the upper body 48 and the lower body 49 are fixed using a bonding material such as an adhesive, with the biosensor chip 41 interposed therebetween. After the upper cover 50 and the lower cover 51 are attached to these outsides, the cartridge-side elastic member 52 is attached to cover the outside of the puncture device 47. Therefore, the communication channel 58 is communicated from one end side to the other end side of the biosensor cartridge 14 around the puncture instrument 47.

  As the material of the first substrate 53, the second substrate 54, and the spacer 55, an insulating material film is selected. As the insulating material, ceramics, glass, paper, biodegradable material (for example, polylactic acid microorganisms) Examples include polyesters produced), thermoplastic materials such as polyvinyl chloride, polypropylene, polystyrene, polycarbonate, acrylic resins, polybutylene terephthalate, polyethylene terephthalate (PET), thermosetting resins such as epoxy resins, and plastic materials such as UV curable resins. can do. At this time, a plastic material such as polyethylene terephthalate is preferable from the viewpoint of mechanical strength, flexibility, and ease of chip fabrication and processing. Representative PET resins include Melinex and Tetron (trade names, manufactured by Teijin DuPont Films, Inc.), Lumirror (trade names, manufactured by Toray Industries, Inc.), and the like.

  Examples of the reagent include glucose oxidase (GOD). In consideration of the blood collection burden of the subject, the volume of the hollow reaction part is preferably 1 μL (microliter) or less, particularly preferably 300 nL (nanoliter) or less. With such a minute hollow reaction part, even if the diameter of the puncture device 47 is small, a sufficient blood volume of the subject can be collected. The puncture device 47 preferably has a diameter of 1000 μm or less.

  As shown in FIG. 6, the lock arm 26 housed in the reduced pressure hermetic chamber 28 is formed in a substantially L shape, and a central portion is rotatably supported by a pin 59, and a locking projection 60 is formed at one end. The other end is connected to the puncture button 24 that is kept airtight in the reduced pressure airtight chamber 28 by the seal member 61. The lock arm 26 is biased in a direction in which the puncture button 24 pops out by a return spring (not shown).

  When the measuring device body 13 is opened, the lock arm 26 is pressed against the biasing spring 33 while the sliding pin 35 is locked to the right end portion of the long hole 34 via the rod 36 and the cylinder 37. Is pulled and moved to the side opposite to the opening 21. At this time, the locking projection 60 biased by the return spring is locked by the engagement hole 62 formed on the lower surface of the pressing member 32 and set at the cartridge loading position A1.

  This operation is automatically performed only by opening the measuring apparatus main body 13. When the puncture button 24 is pressed against the return spring after the measurement device body 13 is closed, the locking projection 60 is released from the engagement hole 62 and the elastic repulsion accumulated in the biasing spring 33 is obtained. The pressing member 32 is moved toward the opening 21 by force to the puncture position (shown in FIG. 9) A2.

  Next, the measurement procedure of the biosensor measurement apparatus 10 will be described with reference to FIGS.

  When the biosensor cartridge 14 shown in FIG. 6 is loaded, when the pressing member 32 is set at the cartridge loading position A1, the biosensor cartridge 14 is loaded into the loading unit 39 in the vacuum hermetic chamber 28. At this time, the pair of detection terminals 42 and 43 included in the biosensor chip 41 included in the biosensor cartridge 14 are electrically connected to the terminal connector portion 40 of the pressing member 32, respectively.

  As shown in FIG. 7, when the measuring device main body 13 is closed by the sampling mechanism housing portion 11 when the biosensor cartridge 14 is loaded in the loading portion 39, the measuring device main body 13 is brought into close contact with the seal member 46. The upper opening side of the decompression hermetic chamber 28 is closed. In the pressing member 32, only the sliding pin 35 moves toward the opening 21 in the long hole 34 while the locking projection 60 of the lock arm 26 is locked in the engaging hole 62 of the pressing member 32. By closing the measurement apparatus main body 13 in the collection mechanism storage unit 11, the decompression airtight chamber 28 is in an airtight state except for the opening 21.

  Next, as shown in FIG. 8, while viewing the opening 21 of the puncture member 20, the user brings the storage unit side elastic member 22 into contact with the subject and presses the pump operation button 23. As a result, the gas in the reduced pressure hermetic chamber 28 whose opening 21 is closed by contacting the subject is the first stage in which the pressure is reduced as the negative pressure pump 30 is driven. In this first stage, the inside of the reduced pressure airtight chamber 28 is depressurized, so that the subject in contact with the storage unit side elastic member 22 becomes congested and rises in the opening 21 so that good puncture can be performed.

  Next, as shown in FIG. 9, when the puncture button 24 is pressed by the user, the locking projection 60 of the lock arm 26 is released from the engagement hole 62 and is stored in the biasing spring 33. This is a second stage in which the pressing member 32 is moved toward the opening 21 to the puncture position A2 by the repulsive force. In the second stage, the reduced pressure state of the reduced pressure hermetic chamber 28 is maintained together with the first stage. Accordingly, the biosensor cartridge 14 is punctured into the subject in which the puncture instrument 47 is congested through the needle hole 63 provided in the cartridge-side elastic member 52 while the cartridge-side elastic member 52 collides with the subject and deforms. The blood flowing out from the puncture rod is introduced from the inside of the cartridge side elastic member 52 into the hollow reaction part of the biosensor chip 41. That is, by introducing blood into the cartridge 14 under reduced pressure, blood is smoothly introduced into the hollow reaction part due to the pressure difference between the pressure at which blood is ejected from the body and the pressure reduction due to the reduced pressure within the cartridge 14.

  At this time, since the communication flow path 58 is formed from the inside of the cartridge side elastic member 52 mounted so as to cover the outside of the puncture device 47 toward the other end of the lower body 49, the blood is hollow. To be introduced efficiently. Thereby, the blood introduced into the hollow reaction part reacts with the reagent, so that the measurement circuit part 18 is based on the fluctuation of the voltage level (current level) between both the contacts 56 and 57 of both detection terminals 42 and 43. Calculates and measures the components in the blood, and displays the blood glucose level data on the display unit 17 through the control circuit unit 19. Then, after the measurement, the depressurized state in the cartridge 14 is released by pressing the pump operation button 23 again.

  As described above, according to the biosensor measurement device 10 of the present embodiment, when the negative pressure pump 30 is driven, the reduced pressure hermetic chamber 28 that is a single space communicated with the negative pressure pump 30 is formed. Depressurized. Then, the pressing member 32 of the puncture mechanism 25, the urging spring 33, and the lock arm 26 housed in the reduced pressure hermetic chamber 28 are actuated, and the puncture instrument 47 of the biosensor cartridge 14 is punctured into the subject. Collection and measurement of biological material in the sample are performed. Thereby, since the negative pressure pump 30 is driven only a single number of times, failure during sample collection can be prevented and the success rate of puncture and collection can be improved.

  In addition, according to the biosensor measurement device 10 of the present embodiment, in the first stage, when the negative pressure pump 30 is driven by the accommodating portion-side elastic member 22 of the opening 21 coming into contact with the subject, and second At this stage, when the puncture instrument 47 of the biosensor cartridge 14 is punctured into the subject after the negative pressure pump 30 is driven, the decompression state of the decompression airtight chamber 28 is maintained. This eliminates the need to drive the negative pressure pump 30 multiple times while still in contact with the subject, facilitating the handling of the user, preventing failure during sample collection and preventing puncture and collection. The success rate can be improved.

  In addition, according to the biosensor measurement device 10 of the present embodiment, when the opening 21 is brought into contact with the subject, the annular storage portion side elastic member 22 attached to the contact side of the subject through the opening 21 is provided. It is elastically contacted with the subject. When the puncture instrument 47 of the biosensor cartridge 14 is punctured into the subject, the cartridge-side elastic member 52 of the biosensor cartridge 14 is elastically applied to the subject on the inner peripheral side of the storage unit-side elastic member 22. Touched. As a result, the sample can be collected in the cartridge-side elastic member 52 in the opening 21 that is blocked from the atmosphere by the contact of the storage unit-side elastic member 22, and the sample can be collected efficiently.

Further, according to the biosensor measurement device 10 of the present embodiment, when the cartridge-side elastic member 52 of the biosensor cartridge 14 is elastically contacted with the subject on the inner peripheral side of the storage unit-side elastic member 22, Since a negative pressure is generated in the communication flow path 58 inside the cartridge side elastic member 52, the sample can be efficiently advanced to the inside of the cartridge side elastic member 52 to reliably avoid a sampling failure.
Further, if the biosensor measurement device 10 is turned upside down and used with the subject's finger placed on the storage unit elastic member 22 at the upper end of the device, in addition to the above-described decompression effect, More reliable introduction can be expected by dropping.

  Note that the biosensor measurement device according to the present invention is not limited to the above-described embodiment, and can be appropriately modified and improved.

FIG. 1 is an external perspective view of a biosensor measuring apparatus according to an embodiment of the present invention. It is a bottom view of the biosensor measuring apparatus of FIG. It is an external appearance perspective view of the state which opened the measuring device main body of the biosensor measuring device of FIG. It is a principal part disassembled perspective view of the biosensor cartridge used for the biosensor measuring apparatus of FIG. It is a longitudinal cross-sectional view of the biosensor cartridge of FIG. It is a longitudinal cross-sectional view around the decompression airtight chamber before loading of the biosensor cartridge for explaining the measurement operation of the biosensor measurement device of FIG. It is a longitudinal cross-sectional view around the decompression airtight chamber after loading the biosensor cartridge for explaining the measurement operation of the biosensor measurement device of FIG. It is a longitudinal cross-sectional view around the pressure-reduced airtight chamber in the 1st step explaining the measurement operation | movement of the biosensor measuring apparatus of FIG. It is a longitudinal cross-sectional view around the decompression airtight chamber in the 2nd step explaining the measurement operation | movement of the biosensor measuring apparatus of FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Biosensor measuring apparatus 11 Sampling mechanism storage part 13 Measuring apparatus main body 14 Biosensor cartridge 21 Opening part 22 Storage part side elastic member 25 Puncture mechanism 27 Decompression mechanism storage chamber 28 Depressurization airtight chamber 30 Negative pressure pump (decompression mechanism)
41 Biosensor chip 47 Puncturing instrument 52 Cartridge side elastic member 58 Communication channel

Claims (5)

A biosensor cartridge in which a puncture device for puncturing a subject and a biosensor chip for collecting a sample obtained by puncturing the subject are loaded, and a living body in the collected sample A biosensor measurement device for measuring a substance,
A measuring device body;
A collection mechanism storage unit;
A decompression mechanism housing chamber formed in the collection mechanism housing portion for housing the decompression mechanism;
A decompression hermetic chamber formed in the collection mechanism storage and communicated with the decompression mechanism;
A biosensor measurement apparatus, wherein a storage section for loading the biosensor cartridge is provided in the vacuum hermetic chamber.   The reduced pressure hermetic chamber has an opening that contacts the subject, the first stage in which the opening contacts the subject and the decompression mechanism is driven, and the decompression mechanism is driven to 2. The biosensor measurement apparatus according to claim 1, wherein a reduced pressure state can be maintained through a second stage in which the puncture device of the biosensor cartridge is punctured into the subject.   3. The biosensor measurement according to claim 1, wherein a sealing member that maintains airtightness is interposed on a contact surface between the measurement device main body defining the decompression hermetic chamber and the sampling mechanism housing portion. apparatus.   The biosensor measurement device according to any one of claims 1 to 3, wherein the collection mechanism storage unit is connected to the measurement device main body through a hinge member so as to be freely opened and closed. A pressure member that is movable through an urging spring and is loaded with the biosensor cartridge in the reduced pressure airtight chamber,
A sliding pin movably attached to the pressing member;
A rod with a cylinder for rotatably connecting the sliding pin to the measuring device body;
A lock arm connected to the puncture button and rotatably supported,
By opening the measuring device main body, the pressing member is moved against the urging spring through the rod with the cylinder and locked to the lock arm,
After the biosensor cartridge is loaded, the measurement device main body is closed and the puncture button is pressed, so that the pressing member is unlocked, and the pressing member is moved together with the biosensor cartridge by the biasing spring. The biosensor measurement device according to any one of claims 1 to 4, wherein the biosensor measurement device moves to a puncture position by a repulsive force.

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