JP2009082383A - Denture stabilizer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a denture stabilizer which can be easily taken out of a tube container in spite of its keeping tackiness essential to denture stabilizers and which is highly transparent and aesthetically excellent. <P>SOLUTION: A denture stabilizer characterized by comprising 5 to 18 wt.% of a cellulose derivative whose 2% aqueous solution exhibits viscosity of 20 to 1,500 mPa s or a salt thereof, 4 to 30 wt.% of a polyhydric alcohol, and water at a weight ratio of the cellulose derivative or salt thereof to the polyhydric alcohol of 1:0.5 to 1:2.0 (weight ratio) and by having a consistency of 25 to 38 mm and a tack of 450 gw or above. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  TECHNICAL FIELD The present invention relates to a denture stabilizer used to fill a gap between a denture base and a ridge and to eliminate the rattle of the denture and to improve the reduction of masticatory force. It is related with the denture stabilizer which improved the ease of taking out from a tube-shaped container and the aesthetics at the time of use, maintaining a property.

  Conventional denture stabilizers include water-insoluble paste denture stabilizers mainly composed of vinyl acetate resin, water-soluble paste denture stabilizers in which water-soluble polymers are dispersed in mineral oil, and water-soluble high denture stabilizers. Powdered denture stabilizers composed of molecules are known.

  The water-insoluble paste denture stabilizer fills the gap formed between the denture and the oral mucosa and does not have adhesiveness. On the other hand, water-soluble paste-like denture stabilizers show adhesiveness when dissolved in saliva, but the main ingredient is mineral oil (mainly petrolatums and paraffins), so there is an unpleasant sensation specific to oil-based preparations in the oral cavity. Presents. In addition, when a powder denture stabilizer is applied to a denture, the powder scatters and the operability during application is not good.

As means for solving these problems, Patent Document 1 proposes a denture stabilizer composed of water or artificial saliva, a water-soluble polymer, and glycerin. Since this denture stabilizer is a water-soluble paste and does not contain mineral oil, it does not exhibit the unpleasantness peculiar to oil-based preparations.
Japanese Patent No. 3515761

  It is considered that such a water-soluble paste denture stabilizer is preferably sold in a tube-shaped container. However, in order to stabilize the denture in the oral cavity, the paste is improved. Since it becomes hard, it becomes very difficult to squeeze out from the tubular container. Since denture stabilizers are products used by relatively elderly people, inconvenience arises when they are difficult to remove from a tube-shaped container. For this reason, while maintaining the adhesiveness required as a denture stabilizer, it is requested | required that a certain amount of fluidity | liquidity is hold | maintained and the ease of taking out from a tube-shaped container is ensured.

  In addition, if a denture is stuck to the oral mucosa using a denture stabilizer, the denture stabilizer may protrude from the gap between the denture and the oral mucosa. It is desirable that the stabilizer be transparent.

  In view of the above-mentioned situation, the present invention is excellent in ease of taking out from a tube-like container while maintaining the necessary adhesiveness as a denture stabilizer, and has high transparency and excellent aesthetics. It is an object to provide an agent.

  As a result of intensive studies, the present inventors have used a cellulose derivative or a salt thereof, a polyhydric alcohol and water, and use a cellulose derivative or a salt thereof having a specific viscosity and a denture stable. It has been found that the above problems can be solved by adjusting the consistency and adhesive strength of the agent to be in a specific range, and the present invention has been completed.

  That is, the present invention includes a cellulose derivative or a salt thereof having a viscosity of 20 to 1500 mPa · s in a 2% aqueous solution, 5 to 18% by weight, 4 to 30% by weight of a polyhydric alcohol, and water, and the cellulose derivative. Or the ratio of the salt and the said polyhydric alcohol is 1: 0.5-1: 2.0 (weight ratio), Consistency is 25 mm-38 mm, Adhesive force is 450 g weight or more, It is characterized by the above-mentioned. It relates to a denture stabilizer.

  Preferably, the viscosity of a 2% aqueous solution of a cellulose derivative or a salt thereof is 20 mPa · s or more and less than 150 mPa · s, the blending amount thereof is 13 to 17% by weight, and the blending amount of the polyhydric alcohol is 7.5 to 30% by weight. In this case, the amount of water is preferably 53 to 79.5% by weight.

  Preferably, the viscosity of a 2% aqueous solution of a cellulose derivative or a salt thereof is 150 to 1500 mPa · s, the blending amount is 6 to 10% by weight, and the blending amount of the polyhydric alcohol is 4 to 16% by weight. It is. In this case, the amount of water is preferably 74 to 90% by weight.

  Further preferably, the salt of the cellulose derivative is sodium carboxymethyl cellulose.

  According to the present invention, there is provided a denture stabilizer that is excellent in ease of taking out from a tube-shaped container while maintaining the necessary adhesiveness as a denture stabilizer, and has high transparency and excellent aesthetics. be able to.

  The present invention is described in detail below.

  The denture stabilizer of the present invention is an aqueous preparation containing a cellulose derivative or a salt thereof, a polyhydric alcohol, and water as essential components, and is water-soluble and exhibits a paste form.

  A cellulose derivative or a salt thereof is dissolved or gelled in water to cause stickiness, and a 2% aqueous solution having a viscosity of 20 to 1500 mPa · s is used. The viscosity of this 2% aqueous solution was measured with a BM viscometer after preparing a 2% aqueous solution and adjusting it to 25 ° C. If the viscosity of the 2% aqueous solution of the cellulose derivative or salt thereof is less than 20 mPa · s, the denture stabilizer cannot maintain the paste form, and sufficient adhesive strength cannot be ensured. On the other hand, when it exceeds 1500 mPa · s, the preparation becomes too hard and difficult to take out from the tube-like container, and the preparation becomes cloudy and it becomes difficult to achieve sufficient transparency. In addition, the cellulose derivative or its salt which has specific viscosity is widely marketed, and can utilize this in this invention.

  Although it does not specifically limit as a kind of cellulose derivative or its salt, For example, alkyl cellulose (for example, methylcellulose, ethylcellulose, etc.) which is water-soluble cellulose ether, Hydroxylated alkylcellulose (for example, hydroxypropylmethylcellulose, hydroxyethylcellulose, etc.), Examples include alkali metal carboxymethyl cellulose (for example, sodium carboxymethyl cellulose, potassium carboxymethyl cellulose), alkali metal cellulose sulfate and the like. Of these, only one type may be used, or a plurality of types may be used in combination. Of these, sodium carboxymethylcellulose is preferred because of its swelling or gelling performance and high adhesiveness.

  A polyhydric alcohol is a component which improves the adhesiveness of a formulation by coexisting with a cellulose derivative or a salt thereof and water, and is not particularly limited as long as it is a compound having two or more alcoholic hydroxyl groups. Specific examples include glycerin, propylene glycol, sorbitol, polyethylene glycol, and the like. Of these, only one type may be used, or a plurality of types may be used in combination. Among these, glycerin is preferable from the viewpoints of tackiness and consistency.

  Furthermore, the denture stabilizer of the present invention contains water, but the water that can be used may be normal purified water or artificial saliva. By blending this, a water-soluble paste-form preparation can be obtained.

  In the denture stabilizer of the present invention, the blending amount of the cellulose derivative or a salt thereof is in the range of 5 to 18% by weight, and the blending amount of the polyhydric alcohol is in the range of 4 to 30% by weight. The remaining amount is occupied by water excluding any additives described later. Further, the cellulose derivative or a salt thereof and the polyhydric alcohol are used in a range satisfying 1: 0.5 to 1: 2.0 by weight ratio. When the blending amount of the cellulose derivative or its salt is too small, the denture stabilizer does not become a paste and cannot exhibit sufficient adhesiveness, so that the denture cannot be stably maintained in the oral cavity. On the other hand, when the blending amount is too large, it becomes difficult to take out the tube-like container due to the hardened preparation, and it becomes difficult to achieve sufficient transparency.

  The denture stabilizer of the present invention has a consistency of 25 mm to 38 mm and an adhesive strength of 450 g weight or more. By satisfying the above range, it is possible to achieve both the adhesiveness necessary for the denture stabilizer and the ease of taking out from the tube-shaped container, and further ensure the transparency of the preparation. The adhesive strength is preferably 700 g weight or more, particularly preferably 1000 g weight or more. As an upper limit, about 2000 g weight or less can be used conveniently.

  In order to obtain a denture stabilizer that satisfies the above-mentioned relationship between consistency and adhesive strength, the 2% aqueous solution viscosity of the cellulose derivative or salt thereof to be blended, its blending amount, the blending amount of the polyhydric alcohol, and both The ratio may be adjusted as appropriate within the scope of the present invention.

  The adjustment method can be easily understood by comparing Examples and Comparative Examples described later, but as a general tendency, when using a cellulose derivative or a salt thereof having a low 2% aqueous solution viscosity, It is desirable that the blending amount and the blending amount of the polyhydric alcohol are large. Conversely, when a cellulose derivative having a high 2% aqueous solution viscosity or a salt thereof is used, it is desirable that the blending amount or the blending amount of the polyhydric alcohol is small.

  As a specific embodiment satisfying such a tendency, when the viscosity of a 2% aqueous solution of a cellulose derivative or a salt thereof is 20 mPa · s or more and less than 150 mPa · s, the blending amount is 13 to 17% by weight. The blending amount of the polyhydric alcohol is 7.5 to 30% by weight. At this time, the blending amount of water is preferably 53 to 79.5% by weight.

  As another aspect, when the viscosity of a 2% aqueous solution of a cellulose derivative or a salt thereof is 150 to 1500 mPa · s, the blending amount is 6 to 10% by weight, and the blending amount of the polyhydric alcohol Is 4 to 16% by weight. At this time, the amount of water is preferably 74 to 90% by weight.

  In addition to the above components, the denture stabilizer of the present invention includes a plasticizer, an emulsifier, a viscosity modifier, a water-insoluble powder, an antiseptic, a metal soap, a solvent, and a solubilizer in order to give the denture stabilizer the desired properties. As long as the effects of the present invention are not impaired, known additives such as stabilizers, deodorants, functional ingredients, enzymes, refreshing agents, fragrances, and coloring agents may be appropriately blended.

  Examples of the plasticizer include beeswax, wood wax, carnauba wax, and candelilla wax.

  Examples of emulsifiers include glycerin fatty acid esters such as glycerin monostearate, sorbitan fatty acid esters such as sorbitan monostearate, and sucrose fatty acid esters such as sucrose stearate and sucrose laurate.

  Examples of the water-insoluble powder include calcium carbonate, calcium phosphate, plastic powder, talc, silica, bentonite, and zeolite.

  Examples of the preservative include benzoic acid, sodium benzoate, methyl paraben, ethyl paraben, and propyl paraben.

  An example of the metal soap is calcium stearate.

  An example of the solvent is phenoxyethanol.

  Examples of solubilizers include polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid esters such as polyethylene glycol monooleate, N-acyl amino acid salts such as sodium N-lauroyl sarcosine, and alkyls such as lauryldimethylaminoacetic acid betaine. Examples include (amide) betaines, polyoxyalkylene lauryl ethers such as polyoxyethylene lauryl ether, polyoxyethylene alkyl ethers, alkyl alkanol amides such as coconut oil fatty acid monoethanolamide, and the like.

  Examples of the stabilizer include titanium oxide, sodium chloride, potassium chloride, magnesium chloride, aluminum lactate and the like.

  Examples of the deodorant include polyphenols extracted from copper chlorophyllin sodium, coffee, green tea, grapes and the like.

  As functional components, anti-inflammatory agents such as glycyrrhetinic acid, glycyrrhetinic acid salt, glycyrrhizic acid, glycyrrhizinate, isopropylmethylphenol, triclosan, cetylpyridinium chloride, decalinium chloride, benzethonium chloride, benzalkonium chloride, chlorhexidines, Examples include bactericides such as hinokitiol, antibiotics, ascorbic acid, ascorbic acid derivatives, vitamins such as tocopherol acetate, and the like.

  Examples of the enzyme include dextranase, amylase, protease, mutanase, lytic enzyme, lysozyme and the like.

  Examples of the refreshing agent include l-menthol, dl-menthol, menthol derivatives, carvone and the like.

  It is also preferable to add a sodium / calcium methoxyethylene maleic anhydride copolymer salt in order to reduce the solubility of the denture stabilizer in the oral cavity in the oral cavity and gradually dissolve the agent.

  In order to produce the denture stabilizer according to the present invention, for example, water, a polyhydric alcohol, and a cellulose derivative or a salt thereof are mixed, and the cellulose derivative or a salt thereof is dissolved or gelled in water, thereby do it.

  By filling the denture stabilizer of the present invention in a tube-shaped container, it is possible to prevent volatilization of the blended components during storage, mixing of foreign substances, and the like. Since the denture stabilizer of this invention is excellent in the ease of taking out from a tube-shaped container, even if a user is an elderly person, it can squeeze out from a tube-shaped container easily. Although it does not specifically limit as a tube-shaped container which can be filled with the denture stabilizer of this invention, For example, the tube made from aluminum, the multilayer tube made from an aluminum epoxy phenol resin, the multilayer tube made from aluminum polyethylene, an aluminum polyethylene polyethylene epoxy An aluminum laminate tube such as a phenol resin multilayer tube may be used.

EXAMPLES The present invention will be described in detail below with reference to examples, but the present invention is not limited to these examples.
Examples 1-7 and Comparative Examples 1-8
Mixing sodium carboxymethylcellulose having a 2% aqueous solution viscosity shown in Table 1, glycerin, and purified water at a weight percentage shown in Table 1, and sufficiently stirring the cellulose to dissolve or gel the water, thereby being water-soluble. A pasty denture stabilizer was produced.

The obtained denture stabilizer was evaluated according to the following items. The obtained results are shown in Table 1.
a) Adhesive strength About the obtained denture stabilizer, the adhesive strength 1 minute after application | coating was measured by the test method of JIS-T-6525-1 adhesive strength test I. When the obtained numerical value was 450 g weight or more, it was determined as ◯, and when it was less than 450 g weight, it was determined as x.
b) Consistency About the obtained denture stabilizer, the consistency was measured by the test method of JIS-T-6525-2 consistency. When the obtained numerical value was within the range of 25 to 38 mm, it was determined as “good”, and when it was not within this range, it was determined as “poor”.
c) Ease of taking out After filling the obtained denture stabilizer in an aluminum laminate tube, when the tester applies force to the tube to squeeze out the denture stabilizer, the easiness of taking out is based on the following evaluation criteria. Judgment was based on experience.
○: Can be easily squeezed Δ: Can be squeezed ×: Hard and cannot be squeezed XX: Too soft and overflowing from the tube d) Transparency The obtained denture stabilizer was visually evaluated.
○: Transparent.
(Triangle | delta): Turbidity is seen and transparency is not enough.

表１から明らかなように、実施例１〜７で得られた義歯安定剤は十分な粘着力を保持しながらも、アルミラミネートチューブからの出しやすさが良好であり、さらに透明な製剤であって審美性に優れている。

As is clear from Table 1, the denture stabilizers obtained in Examples 1 to 7 have good adhesiveness and are easy to take out from the aluminum laminate tube, and are transparent preparations. Excellent aesthetics.

Claims (6)

A 2% aqueous solution having a viscosity of 20 to 1500 mPa · s, a cellulose derivative or a salt thereof, 5 to 18% by weight, a polyhydric alcohol 4 to 30% by weight, water, and
The ratio of the cellulose derivative or salt thereof and the polyhydric alcohol is 1: 0.5 to 1: 2.0 (weight ratio),
The consistency is 25 mm to 38 mm,
A denture stabilizer characterized by having an adhesive strength of 450 g weight or more.   The viscosity of a 2% aqueous solution of a cellulose derivative or a salt thereof is 20 mPa · s or more and less than 150 mPa · s, the blending amount thereof is 13 to 17% by weight, and the blending amount of the polyhydric alcohol is 7.5 to 30% by weight. The denture stabilizer according to claim 1, wherein   The denture stabilizer of Claim 2 whose compounding quantity of water is 53-79.5 weight%.   The viscosity of a 2% aqueous solution of a cellulose derivative or a salt thereof is 150 to 1500 mPa · s, the blending amount thereof is 6 to 10% by weight, and the blending amount of the polyhydric alcohol is 4 to 16% by weight. The denture stabilizer according to 1.   The denture stabilizer of Claim 4 whose compounding quantity of water is 74 to 90 weight%. The denture stabilizer in any one of Claims 1-5 whose salt of a cellulose derivative is carboxymethylcellulose sodium.