JP2009072210A5 - - Google Patents
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- JP2009072210A5 JP2009072210A5 JP2008325769A JP2008325769A JP2009072210A5 JP 2009072210 A5 JP2009072210 A5 JP 2009072210A5 JP 2008325769 A JP2008325769 A JP 2008325769A JP 2008325769 A JP2008325769 A JP 2008325769A JP 2009072210 A5 JP2009072210 A5 JP 2009072210A5
- Authority
- JP
- Japan
- Prior art keywords
- ala
- leu
- arg
- asp
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- NFNVDJGXRFEYTK-YUMQZZPRSA-N Leu-Glu Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O NFNVDJGXRFEYTK-YUMQZZPRSA-N 0.000 description 5
- UQHGAYSULGRWRG-WHFBIAKZSA-N Glu-Ser Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CO)C(O)=O UQHGAYSULGRWRG-WHFBIAKZSA-N 0.000 description 4
- QXRNAOYBCYVZCD-BQBZGAKWSA-N (2S)-6-amino-2-[[(2S)-2-aminopropanoyl]amino]hexanoic acid Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN QXRNAOYBCYVZCD-BQBZGAKWSA-N 0.000 description 3
- CXISPYVYMQWFLE-VKHMYHEASA-N Ala-Gly Chemical compound C[C@H]([NH3+])C(=O)NCC([O-])=O CXISPYVYMQWFLE-VKHMYHEASA-N 0.000 description 3
- PMGDADKJMCOXHX-BQBZGAKWSA-N Arg-Gln Chemical compound NC(=N)NCCC[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(O)=O PMGDADKJMCOXHX-BQBZGAKWSA-N 0.000 description 3
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- 241000972623 Streptomyces albulus Species 0.000 description 3
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- 108010008355 arginyl-glutamine Proteins 0.000 description 3
- 108010068380 arginylarginine Proteins 0.000 description 3
- 108010040443 aspartyl-aspartic acid Proteins 0.000 description 3
- 108010012581 phenylalanylglutamate Proteins 0.000 description 3
- AAKRWBIIGKPOKQ-ONGXEEELSA-N 2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]acetic acid Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)NCC(O)=O AAKRWBIIGKPOKQ-ONGXEEELSA-N 0.000 description 2
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- IPWKGIFRRBGCJO-IMJSIDKUSA-N Ala-Ser Chemical compound C[C@H]([NH3+])C(=O)N[C@@H](CO)C([O-])=O IPWKGIFRRBGCJO-IMJSIDKUSA-N 0.000 description 2
- OMLWNBVRVJYMBQ-YUMQZZPRSA-N Arg-Arg Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O OMLWNBVRVJYMBQ-YUMQZZPRSA-N 0.000 description 2
- IJYZHIOOBGIINM-WDSKDSINSA-N Arg-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCN=C(N)N IJYZHIOOBGIINM-WDSKDSINSA-N 0.000 description 2
- FRYULLIZUDQONW-IMJSIDKUSA-N Asp-Asp Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(O)=O FRYULLIZUDQONW-IMJSIDKUSA-N 0.000 description 2
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- ZVDPYSVOZFINEE-UHFFFAOYSA-N Aspartyl-Leucine Chemical compound CC(C)CC(C(O)=O)NC(=O)C(N)CC(O)=O ZVDPYSVOZFINEE-UHFFFAOYSA-N 0.000 description 2
- MFBYPDKTAJXHNI-VKHMYHEASA-N Gly-Cys Chemical compound [NH3+]CC(=O)N[C@@H](CS)C([O-])=O MFBYPDKTAJXHNI-VKHMYHEASA-N 0.000 description 2
- DKEXFJVMVGETOO-LURJTMIESA-N Gly-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)CN DKEXFJVMVGETOO-LURJTMIESA-N 0.000 description 2
- NIKBMHGRNAPJFW-UHFFFAOYSA-N Histidinyl-Arginine Chemical compound NC(=N)NCCCC(C(O)=O)NC(=O)C(N)CC1=CN=CN1 NIKBMHGRNAPJFW-UHFFFAOYSA-N 0.000 description 2
- HYXQKVOADYPQEA-CIUDSAMLSA-N Ile-Arg Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCN=C(N)N HYXQKVOADYPQEA-CIUDSAMLSA-N 0.000 description 2
- VTJUNIYRYIAIHF-IUCAKERBSA-N Leu-Pro Chemical compound CC(C)C[C@H](N)C(=O)N1CCC[C@H]1C(O)=O VTJUNIYRYIAIHF-IUCAKERBSA-N 0.000 description 2
- 108010079364 N-glycylalanine Proteins 0.000 description 2
- JXWLMUIXUXLIJR-QWRGUYRKSA-N Phe-Glu Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 JXWLMUIXUXLIJR-QWRGUYRKSA-N 0.000 description 2
- ZKQOUHVVXABNDG-IUCAKERBSA-N Pro-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1 ZKQOUHVVXABNDG-IUCAKERBSA-N 0.000 description 2
- IWIANZLCJVYEFX-RYUDHWBXSA-N Pro-Phe Chemical compound C([C@@H](C(=O)O)NC(=O)[C@H]1NCCC1)C1=CC=CC=C1 IWIANZLCJVYEFX-RYUDHWBXSA-N 0.000 description 2
- SSJMZMUVNKEENT-IMJSIDKUSA-N Ser-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](N)CO SSJMZMUVNKEENT-IMJSIDKUSA-N 0.000 description 2
- 108010047495 alanylglycine Proteins 0.000 description 2
- 108010077245 asparaginyl-proline Proteins 0.000 description 2
- 108010093581 aspartyl-proline Proteins 0.000 description 2
- 108010038633 aspartylglutamate Proteins 0.000 description 2
- 229920003013 deoxyribonucleic acid Polymers 0.000 description 2
- 108010057083 glutamyl-aspartyl-leucine Proteins 0.000 description 2
- 108010049041 glutamylalanine Proteins 0.000 description 2
- 108010057821 leucylproline Proteins 0.000 description 2
- 108010009298 lysylglutamic acid Proteins 0.000 description 2
- 108010044655 lysylproline Proteins 0.000 description 2
- ZJPGOXWRFNKIQL-JYJNAYRXSA-N (2S)-1-[(2S)-1-[(2S)-2-amino-3-phenylpropanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid Chemical compound C([C@H](N)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(O)=O)C1=CC=CC=C1 ZJPGOXWRFNKIQL-JYJNAYRXSA-N 0.000 description 1
- LQJAALCCPOTJGB-YUMQZZPRSA-N (2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carboxylic acid Chemical compound NC(N)=NCCC[C@H](N)C(=O)N1CCC[C@H]1C(O)=O LQJAALCCPOTJGB-YUMQZZPRSA-N 0.000 description 1
- ZNGPROMGGGFOAA-JYJNAYRXSA-N (2S)-2-[[(2S)-2-[[(2S)-2-azaniumyl-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoate Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](C(C)C)C(O)=O)CC1=CC=C(O)C=C1 ZNGPROMGGGFOAA-JYJNAYRXSA-N 0.000 description 1
- LZDNBBYBDGBADK-KBPBESRZSA-N (2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](N)C(C)C)C(O)=O)=CNC2=C1 LZDNBBYBDGBADK-KBPBESRZSA-N 0.000 description 1
- IAJFFZORSWOZPQ-SRVKXCTJSA-N (2S)-4-amino-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoic acid Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O IAJFFZORSWOZPQ-SRVKXCTJSA-N 0.000 description 1
- GJSURZIOUXUGAL-UHFFFAOYSA-N 2-((2,6-Dichlorophenyl)imino)imidazolidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 1
- KTGFOCFYOZQVRJ-UHFFFAOYSA-N 2-[(2-amino-3-methylpentanoyl)amino]pentanedioic acid Chemical compound CCC(C)C(N)C(=O)NC(C(O)=O)CCC(O)=O KTGFOCFYOZQVRJ-UHFFFAOYSA-N 0.000 description 1
- WNGVUZWBXZKQES-YUMQZZPRSA-N 2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]propanoyl]amino]acetic acid Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O WNGVUZWBXZKQES-YUMQZZPRSA-N 0.000 description 1
- RLMISHABBKUNFO-WHFBIAKZSA-N 2-[[(2S)-2-[[(2S)-2-azaniumylpropanoyl]amino]propanoyl]amino]acetate Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O RLMISHABBKUNFO-WHFBIAKZSA-N 0.000 description 1
- HJCMDXDYPOUFDY-WHFBIAKZSA-N Ala-Gln Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O HJCMDXDYPOUFDY-WHFBIAKZSA-N 0.000 description 1
- OMNVYXHOSHNURL-WPRPVWTQSA-N Ala-Phe Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 OMNVYXHOSHNURL-WPRPVWTQSA-N 0.000 description 1
- JQDFGZKKXBEANU-UHFFFAOYSA-N Alanyl-Cysteine Chemical compound CC(N)C(=O)NC(CS)C(O)=O JQDFGZKKXBEANU-UHFFFAOYSA-N 0.000 description 1
- JQFZHHSQMKZLRU-IUCAKERBSA-N Arg-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCN=C(N)N JQFZHHSQMKZLRU-IUCAKERBSA-N 0.000 description 1
- PQBHGSGQZSOLIR-RYUDHWBXSA-N Arg-Phe Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 PQBHGSGQZSOLIR-RYUDHWBXSA-N 0.000 description 1
- BNODVYXZAAXSHW-UHFFFAOYSA-N Arginyl-Histidine Chemical compound NC(=N)NCCCC(N)C(=O)NC(C(O)=O)CC1=CN=CN1 BNODVYXZAAXSHW-UHFFFAOYSA-N 0.000 description 1
- XNSKSTRGQIPTSE-UHFFFAOYSA-N Arginyl-Threonine Chemical compound CC(O)C(C(O)=O)NC(=O)C(N)CCCNC(N)=N XNSKSTRGQIPTSE-UHFFFAOYSA-N 0.000 description 1
- GADKFYNESXNRLC-WDSKDSINSA-N Asn-Pro Chemical compound NC(=O)C[C@H](N)C(=O)N1CCC[C@H]1C(O)=O GADKFYNESXNRLC-WDSKDSINSA-N 0.000 description 1
- KWBQPGIYEZKDEG-FSPLSTOPSA-N Asn-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CC(N)=O KWBQPGIYEZKDEG-FSPLSTOPSA-N 0.000 description 1
- DVUFTQLHHHJEMK-IMJSIDKUSA-N Asp-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O DVUFTQLHHHJEMK-IMJSIDKUSA-N 0.000 description 1
- GSMPSRPMQQDRIB-WHFBIAKZSA-N Asp-Gln Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O GSMPSRPMQQDRIB-WHFBIAKZSA-N 0.000 description 1
- CKAJHWFHHFSCDT-WHFBIAKZSA-N Asp-Glu Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O CKAJHWFHHFSCDT-WHFBIAKZSA-N 0.000 description 1
- JHFNSBBHKSZXKB-VKHMYHEASA-N Asp-Gly Chemical compound OC(=O)C[C@H](N)C(=O)NCC(O)=O JHFNSBBHKSZXKB-VKHMYHEASA-N 0.000 description 1
- ZARXTZFGQZBYFO-JQWIXIFHSA-N Asp-Trp Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](CC(O)=O)N)C(O)=O)=CNC2=C1 ZARXTZFGQZBYFO-JQWIXIFHSA-N 0.000 description 1
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- TWXZVVXRRRRSLT-UHFFFAOYSA-N Asparaginyl-Cysteine Chemical compound NC(=O)CC(N)C(=O)NC(CS)C(O)=O TWXZVVXRRRRSLT-UHFFFAOYSA-N 0.000 description 1
- HXWUJJADFMXNKA-UHFFFAOYSA-N Asparaginyl-Leucine Chemical compound CC(C)CC(C(O)=O)NC(=O)C(N)CC(N)=O HXWUJJADFMXNKA-UHFFFAOYSA-N 0.000 description 1
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- VGRHZPNRCLAHQA-UHFFFAOYSA-N Aspartyl-Asparagine Chemical compound OC(=O)CC(N)C(=O)NC(CC(N)=O)C(O)=O VGRHZPNRCLAHQA-UHFFFAOYSA-N 0.000 description 1
- UKGGPJNBONZZCM-WDSKDSINSA-N Aspartyl-L-proline Chemical compound OC(=O)C[C@H](N)C(=O)N1CCC[C@H]1C(O)=O UKGGPJNBONZZCM-WDSKDSINSA-N 0.000 description 1
- NTQDELBZOMWXRS-UHFFFAOYSA-N Aspartyl-Threonine Chemical compound CC(O)C(C(O)=O)NC(=O)C(N)CC(O)=O NTQDELBZOMWXRS-UHFFFAOYSA-N 0.000 description 1
- YBAFDPFAUTYYRW-YUMQZZPRSA-N Glu-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CCC(O)=O YBAFDPFAUTYYRW-YUMQZZPRSA-N 0.000 description 1
- BBBXWRGITSUJPB-YUMQZZPRSA-N Glu-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CCC(O)=O BBBXWRGITSUJPB-YUMQZZPRSA-N 0.000 description 1
- JZOYFBPIEHCDFV-UHFFFAOYSA-N Glutaminyl-Histidine Chemical compound NC(=O)CCC(N)C(=O)NC(C(O)=O)CC1=CN=CN1 JZOYFBPIEHCDFV-UHFFFAOYSA-N 0.000 description 1
- CLSDNFWKGFJIBZ-UHFFFAOYSA-N Glutaminyl-Lysine Chemical compound NCCCCC(C(O)=O)NC(=O)C(N)CCC(N)=O CLSDNFWKGFJIBZ-UHFFFAOYSA-N 0.000 description 1
- MRVYVEQPNDSWLH-UHFFFAOYSA-N Glutaminyl-Valine Chemical compound CC(C)C(C(O)=O)NC(=O)C(N)CCC(N)=O MRVYVEQPNDSWLH-UHFFFAOYSA-N 0.000 description 1
- SCCPDJAQCXWPTF-VKHMYHEASA-N Gly-Asp Chemical compound NCC(=O)N[C@H](C(O)=O)CC(O)=O SCCPDJAQCXWPTF-VKHMYHEASA-N 0.000 description 1
- IEFJWDNGDZAYNZ-BYPYZUCNSA-N Gly-Glu Chemical compound NCC(=O)N[C@H](C(O)=O)CCC(O)=O IEFJWDNGDZAYNZ-BYPYZUCNSA-N 0.000 description 1
- BCCRXDTUTZHDEU-VKHMYHEASA-N Gly-Ser Chemical compound NCC(=O)N[C@@H](CO)C(O)=O BCCRXDTUTZHDEU-VKHMYHEASA-N 0.000 description 1
- LNCFUHAPNTYMJB-IUCAKERBSA-N His-Pro Chemical compound C([C@H](N)C(=O)N1[C@@H](CCC1)C(O)=O)C1=CN=CN1 LNCFUHAPNTYMJB-IUCAKERBSA-N 0.000 description 1
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- HFKJBCPRWWGPEY-BQBZGAKWSA-N L-arginyl-L-glutamic acid Chemical compound NC(=N)NCCC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(O)=O HFKJBCPRWWGPEY-BQBZGAKWSA-N 0.000 description 1
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- RNKSNIBMTUYWSH-YFKPBYRVSA-N L-prolylglycine Chemical compound [O-]C(=O)CNC(=O)[C@@H]1CCC[NH2+]1 RNKSNIBMTUYWSH-YFKPBYRVSA-N 0.000 description 1
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- NDYNTQWSJLPEMK-UHFFFAOYSA-N Methionyl-Cysteine Chemical group CSCCC(N)C(=O)NC(CS)C(O)=O NDYNTQWSJLPEMK-UHFFFAOYSA-N 0.000 description 1
- 108010002311 N-glycylglutamic acid Proteins 0.000 description 1
- 108010066427 N-valyltryptophan Proteins 0.000 description 1
- 108010047562 NGR peptide Proteins 0.000 description 1
- MIDZLCFIAINOQN-WPRPVWTQSA-N Phe-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](N)CC1=CC=CC=C1 MIDZLCFIAINOQN-WPRPVWTQSA-N 0.000 description 1
- HWMGTNOVUDIKRE-UWVGGRQHSA-N Phe-Asp Chemical compound OC(=O)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 HWMGTNOVUDIKRE-UWVGGRQHSA-N 0.000 description 1
- FADYJNXDPBKVCA-UHFFFAOYSA-N Phenylalanyl-Lysine Chemical compound NCCCCC(C(O)=O)NC(=O)C(N)CC1=CC=CC=C1 FADYJNXDPBKVCA-UHFFFAOYSA-N 0.000 description 1
- FELJDCNGZFDUNR-WDSKDSINSA-N Pro-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1 FELJDCNGZFDUNR-WDSKDSINSA-N 0.000 description 1
- SHAQGFGGJSLLHE-BQBZGAKWSA-N Pro-Gln Chemical compound NC(=O)CC[C@@H](C([O-])=O)NC(=O)[C@@H]1CCC[NH2+]1 SHAQGFGGJSLLHE-BQBZGAKWSA-N 0.000 description 1
- RWCOTTLHDJWHRS-YUMQZZPRSA-N Pro-Pro Chemical compound OC(=O)[C@@H]1CCCN1C(=O)[C@H]1NCCC1 RWCOTTLHDJWHRS-YUMQZZPRSA-N 0.000 description 1
- GVUVRRPYYDHHGK-UHFFFAOYSA-N Prolyl-Threonine Chemical compound CC(O)C(C(O)=O)NC(=O)C1CCCN1 GVUVRRPYYDHHGK-UHFFFAOYSA-N 0.000 description 1
- 108010079005 RDV peptide Proteins 0.000 description 1
- LAFKUZYWNCHOHT-WHFBIAKZSA-N Ser-Glu Chemical compound OC[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O LAFKUZYWNCHOHT-WHFBIAKZSA-N 0.000 description 1
- ILVGMCVCQBJPSH-WDSKDSINSA-N Ser-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CO ILVGMCVCQBJPSH-WDSKDSINSA-N 0.000 description 1
- RZEQTVHJZCIUBT-UHFFFAOYSA-N Serinyl-Arginine Chemical compound OCC(N)C(=O)NC(C(O)=O)CCCNC(N)=N RZEQTVHJZCIUBT-UHFFFAOYSA-N 0.000 description 1
- 241000187747 Streptomyces Species 0.000 description 1
- IOWJRKAVLALBQB-IWGUZYHVSA-N Thr-Asp Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@H](C(O)=O)CC(O)=O IOWJRKAVLALBQB-IWGUZYHVSA-N 0.000 description 1
- BECPPKYKPSRKCP-ZDLURKLDSA-N Thr-Glu Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O BECPPKYKPSRKCP-ZDLURKLDSA-N 0.000 description 1
- BQBCIBCLXBKYHW-CSMHCCOUSA-N Thr-Leu Chemical compound CC(C)C[C@@H](C([O-])=O)NC(=O)[C@@H]([NH3+])[C@@H](C)O BQBCIBCLXBKYHW-CSMHCCOUSA-N 0.000 description 1
- CKHWEVXPLJBEOZ-UHFFFAOYSA-N Threoninyl-Valine Chemical compound CC(C)C(C(O)=O)NC(=O)C(N)C(C)O CKHWEVXPLJBEOZ-UHFFFAOYSA-N 0.000 description 1
- OHGNSVACHBZKSS-KWQFWETISA-N Trp-Ala Chemical compound C1=CC=C2C(C[C@H]([NH3+])C(=O)N[C@@H](C)C([O-])=O)=CNC2=C1 OHGNSVACHBZKSS-KWQFWETISA-N 0.000 description 1
- NQIHMZLGCZNZBN-PXNSSMCTSA-N Trp-Trp Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)N)C(O)=O)=CNC2=C1 NQIHMZLGCZNZBN-PXNSSMCTSA-N 0.000 description 1
- LWFWZRANSFAJDR-JSGCOSHPSA-N Trp-Val Chemical compound C1=CC=C2C(C[C@H](N)C(=O)N[C@@H](C(C)C)C(O)=O)=CNC2=C1 LWFWZRANSFAJDR-JSGCOSHPSA-N 0.000 description 1
- HPYDSVWYXXKHRD-VIFPVBQESA-N Tyr-Gly Chemical compound [O-]C(=O)CNC(=O)[C@@H]([NH3+])CC1=CC=C(O)C=C1 HPYDSVWYXXKHRD-VIFPVBQESA-N 0.000 description 1
- OBTCMSPFOITUIJ-FSPLSTOPSA-N Val-Asp Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CC(O)=O OBTCMSPFOITUIJ-FSPLSTOPSA-N 0.000 description 1
- XXDVDTMEVBYRPK-XPUUQOCRSA-N Val-Gln Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O XXDVDTMEVBYRPK-XPUUQOCRSA-N 0.000 description 1
- JKHXYJKMNSSFFL-IUCAKERBSA-N Val-Lys Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN JKHXYJKMNSSFFL-IUCAKERBSA-N 0.000 description 1
- GIAZPLMMQOERPN-YUMQZZPRSA-N Val-Pro Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1C(O)=O GIAZPLMMQOERPN-YUMQZZPRSA-N 0.000 description 1
- STTYIMSDIYISRG-WDSKDSINSA-N Val-Ser Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](CO)C(O)=O STTYIMSDIYISRG-WDSKDSINSA-N 0.000 description 1
- GVRKWABULJAONN-UHFFFAOYSA-N Valyl-Threonine Chemical compound CC(C)C(N)C(=O)NC(C(C)O)C(O)=O GVRKWABULJAONN-UHFFFAOYSA-N 0.000 description 1
- 108010086434 alanyl-seryl-glycine Proteins 0.000 description 1
- 108010044940 alanylglutamine Proteins 0.000 description 1
- 108010011559 alanylphenylalanine Proteins 0.000 description 1
- 108010013835 arginine glutamate Proteins 0.000 description 1
- 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 description 1
- 108010062796 arginyllysine Proteins 0.000 description 1
- 108010047857 aspartylglycine Proteins 0.000 description 1
- 108010068265 aspartyltyrosine Proteins 0.000 description 1
- 108010080575 glutamyl-aspartyl-alanine Proteins 0.000 description 1
- 108010027668 glycyl-alanyl-valine Proteins 0.000 description 1
- 108010050848 glycylleucine Proteins 0.000 description 1
- 108010084389 glycyltryptophan Proteins 0.000 description 1
- 108010037850 glycylvaline Proteins 0.000 description 1
- 108010040030 histidinoalanine Proteins 0.000 description 1
- 108010025306 histidylleucine Proteins 0.000 description 1
- 108010085325 histidylproline Proteins 0.000 description 1
- 108010044311 leucyl-glycyl-glycine Proteins 0.000 description 1
- 108010034529 leucyl-lysine Proteins 0.000 description 1
- 108010000761 leucylarginine Proteins 0.000 description 1
- 108010072591 lysyl-leucyl-alanyl-arginine Proteins 0.000 description 1
- 108010056582 methionylglutamic acid Proteins 0.000 description 1
- 108010084572 phenylalanyl-valine Proteins 0.000 description 1
- 108010024607 phenylalanylalanine Proteins 0.000 description 1
- QLROSWPKSBORFJ-BQBZGAKWSA-N pro glu Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1 QLROSWPKSBORFJ-BQBZGAKWSA-N 0.000 description 1
- 108010007513 prolyl-glycyl-prolyl-leucine Proteins 0.000 description 1
- 108010077112 prolyl-proline Proteins 0.000 description 1
- 108010087846 prolyl-prolyl-glycine Proteins 0.000 description 1
- 108010029020 prolylglycine Proteins 0.000 description 1
- 108010090894 prolylleucine Proteins 0.000 description 1
- 108010053725 prolylvaline Proteins 0.000 description 1
- 108010048818 seryl-histidine Proteins 0.000 description 1
- 108010071207 serylmethionine Proteins 0.000 description 1
- 108010005652 splenotritin Proteins 0.000 description 1
- IOUPEELXVYPCPG-UHFFFAOYSA-N val-gly Chemical compound CC(C)C(N)C(=O)NCC(O)=O IOUPEELXVYPCPG-UHFFFAOYSA-N 0.000 description 1
- 108010073969 valyllysine Proteins 0.000 description 1
- SITLTJHOQZFJGG-XPUUQOCRSA-N α-Glu-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCC(O)=O SITLTJHOQZFJGG-XPUUQOCRSA-N 0.000 description 1
- DXJZITDUDUPINW-UHFFFAOYSA-N γ-glutamyl-Asparagine Chemical compound NC(=O)CCC(N)C(=O)NC(CC(N)=O)C(O)=O DXJZITDUDUPINW-UHFFFAOYSA-N 0.000 description 1
- ZQFAGNFSIZZYBA-UHFFFAOYSA-N γ-glutamyl-Tryptophan Chemical compound C1=CC=C2C(CC(NC(=O)C(CCC(N)=O)N)C(O)=O)=CNC2=C1 ZQFAGNFSIZZYBA-UHFFFAOYSA-N 0.000 description 1
Description
［表３］
<110> Chisso Corporation
<120> Cyclic plasmid DNA originated from Streptomyces
<130> 730255
<140> JP
<160> 3
<210> 1
<211> 1806
<212> DNA
<213> Plasmid pNO33 originated from Streptomyces albulus IFO 14147 strain
<400> 1
gaattcgatg gtggcccggg gcggacacca caggatcggc cccagcgtca cgccgttcgt 60
ggtcagggcc tcgatcgcgt cccaaccaac ggtggcggtc acccgcaaca cgtcccagct 120
ccgcccgatc ggcacgtcaa cggcgtgccc ggcggcccat gcagcgtgta cgtcatgctt 180
gtccgctcct gcggctgttg cccatcggag cgcgcggacg aagtgctgtc cgatcgtcat 240
cgcgcgccct cctcgtgctc cgggcacgcc cgcacgtccc aactgatgcc ggcgcccgat 300
gcggagacgg tgcgcacgcg cccggcaggg cacaactggg tgcgctggtt gcgggtccgc 360
ccgcagacga tgcaggcgtg cccctgaagt tgccctaacg cggggaaatc agggtctccg 420
acccgatatg cgcgcttgat cggcttttgc tgtgtggtca gtgccattgc tgcactccgc 480
tcactagccc aggtgctccc acgatcagca acggaaccgc tacgtcgcgt atcgggatta 540
cccctagagt gacccctcac acacgtgccg cgcaagtgtc acgcacgtgc gtagcacgtg 600
cgtgacgttc gtacaggtgg acggagaggc ggagaaccct atgtgtgcag ctcgtcgagg 660
tgatacggca gactggaccg aagcaagtgc gcgcaaacga cgcagacgga ggggggcggg 720
tatgccaccg gagccgacca gcccgacggt tcaccgtcgc caactgggcc gcgaactgcg 780
ccaactgagg caggcggcgg ggaaagagat cgaggatgcg gcccagacgt tgggctgtca 840
ccgaagccgg gttagccgga tcgagaacgg gcggggcggc gcggtcgcaa agccgcaaga 900
tgtaaaagac ctgctcacgc tctacggcgt ggacgacgcc ataaagctcg cccgactcct 960
ggcactgctg aacgactccc agaagcccgg atggtgggag agcctggagt ttccgccggg 1020
actcgatgcg ctcgtgggcc tggagaccga tgcgcgcaag gaatcggctt ttgagccgtt 1080
gctgatcccc gggccgctac aggttcctga ctacgcgcgg gctgtgatcc atgcagctcg 1140
ctctcagcat ccggacgagg tcgaagacct ggttcagctc cgggacgggc gcctacgcct 1200
gctgacacgt tctcaaaacc cgttggagct gtgggccgta gtagatgagt ccgtgatccg 1260
tcggcccgtc ggcggcgctc ggacactccg tgatcaactg cggcatctga tggaaatcgc 1320
ggcattgccg aacgtgacgc ttcaggtcgt tccttttgag aaagagagtc accccggact 1380
cggcggctcc tttgcactct tggagttcga ggatgatccg gcggtggtct atgtggacag 1440
catggccggg aacctgtacc tggaaaaagc acgcgacgtg aggcgcttcg tgcgggcctt 1500
cgatctgctg aaggcgtgcg cgctcgaccc tgacgactca gcggccttga tcaaccgtgc 1560
cgcaaaggag agcaaatgag taacaccacc ccgacgccga acgccctgct ggctggcgcc 1620
cagtggttca agtccgaggc gtcaagcgca agcgggggtt gcctcgaagt ggcgtttcta 1680
cccggcgatc tcgtcggcat ccgagacaac gaggacctga ccaacccgcc ctttgtcgtc 1740
accaagcatg tgtggaactg ctgggtcgcc ggcgccaagg caggagaatt cgacccgccc 1800
gcctga 1806
<110> Chisso Corporation
<120> Cyclic plasmid DNA originated from Streptomyces
<130> 730255
<140> JP
<160> 3
<210> 1
<211> 1806
<212> DNA
<213> Plasmid pNO33 originated from Streptomyces albulus IFO 14147 strain
<400> 1
gaattcgatg gtggcccggg gcggacacca caggatcggc cccagcgtca cgccgttcgt 60
ggtcagggcc tcgatcgcgt cccaaccaac ggtggcggtc acccgcaaca cgtcccagct 120
ccgcccgatc ggcacgtcaa cggcgtgccc ggcggcccat gcagcgtgta cgtcatgctt 180
gtccgctcct gcggctgttg cccatcggag cgcgcggacg aagtgctgtc cgatcgtcat 240
cgcgcgccct cctcgtgctc cgggcacgcc cgcacgtccc aactgatgcc ggcgcccgat 300
gcggagacgg tgcgcacgcg cccggcaggg cacaactggg tgcgctggtt gcgggtccgc 360
ccgcagacga tgcaggcgtg cccctgaagt tgccctaacg cggggaaatc agggtctccg 420
acccgatatg cgcgcttgat cggcttttgc tgtgtggtca gtgccattgc tgcactccgc 480
tcactagccc aggtgctccc acgatcagca acggaaccgc tacgtcgcgt atcgggatta 540
cccctagagt gacccctcac acacgtgccg cgcaagtgtc acgcacgtgc gtagcacgtg 600
cgtgacgttc gtacaggtgg acggagaggc ggagaaccct atgtgtgcag ctcgtcgagg 660
tgatacggca gactggaccg aagcaagtgc gcgcaaacga cgcagacgga ggggggcggg 720
tatgccaccg gagccgacca gcccgacggt tcaccgtcgc caactgggcc gcgaactgcg 780
ccaactgagg caggcggcgg ggaaagagat cgaggatgcg gcccagacgt tgggctgtca 840
ccgaagccgg gttagccgga tcgagaacgg gcggggcggc gcggtcgcaa agccgcaaga 900
tgtaaaagac ctgctcacgc tctacggcgt ggacgacgcc ataaagctcg cccgactcct 960
ggcactgctg aacgactccc agaagcccgg atggtgggag agcctggagt ttccgccggg 1020
actcgatgcg ctcgtgggcc tggagaccga tgcgcgcaag gaatcggctt ttgagccgtt 1080
gctgatcccc gggccgctac aggttcctga ctacgcgcgg gctgtgatcc atgcagctcg 1140
ctctcagcat ccggacgagg tcgaagacct ggttcagctc cgggacgggc gcctacgcct 1200
gctgacacgt tctcaaaacc cgttggagct gtgggccgta gtagatgagt ccgtgatccg 1260
tcggcccgtc ggcggcgctc ggacactccg tgatcaactg cggcatctga tggaaatcgc 1320
ggcattgccg aacgtgacgc ttcaggtcgt tccttttgag aaagagagtc accccggact 1380
cggcggctcc tttgcactct tggagttcga ggatgatccg gcggtggtct atgtggacag 1440
catggccggg aacctgtacc tggaaaaagc acgcgacgtg aggcgcttcg tgcgggcctt 1500
cgatctgctg aaggcgtgcg cgctcgaccc tgacgactca gcggccttga tcaaccgtgc 1560
cgcaaaggag agcaaatgag taacaccacc ccgacgccga acgccctgct ggctggcgcc 1620
cagtggttca agtccgaggc gtcaagcgca agcgggggtt gcctcgaagt ggcgtttcta 1680
cccggcgatc tcgtcggcat ccgagacaac gaggacctga ccaacccgcc ctttgtcgtc 1740
accaagcatg tgtggaactg ctgggtcgcc ggcgccaagg caggagaatt cgacccgccc 1800
gcctga 1806
［表４］
<210> 2
<211> 76
<212> PRT
<213> Plasmid pNO33 originated from Streptomyces albulus IFO 14147 strain
<400> 2
N- 末端 Met Ser Asn Thr Thr Pro Thr Pro Asn Ala Leu Leu Ala Gly Ala
1 5 10 15
Gln Trp Phe Lys Ser Glu Ala Ser Ser Ala Ser Gly Gly Cys Leu Glu Val Ala
20 25 30
Phe Leu Pro Gly Asp Leu Val Gly Ile Arg Asp Asn Glu Asp Leu Thr Asn Pro
35 40 45 50
Pro Phe Val Val Thr Lys His Val Trp Asn Cys Trp Val Ala Gly Ala Lys Ala
55 60 65
Gly Glu Phe Asp Pro Pro Ala -C 末端
70 75
<210> 2
<211> 76
<212> PRT
<213> Plasmid pNO33 originated from Streptomyces albulus IFO 14147 strain
<400> 2
N- 末端 Met Ser Asn Thr Thr Pro Thr Pro Asn Ala Leu Leu Ala Gly Ala
1 5 10 15
Gln Trp Phe Lys Ser Glu Ala Ser Ser Ala Ser Gly Gly Cys Leu Glu Val Ala
20 25 30
Phe Leu Pro Gly Asp Leu Val Gly Ile Arg Asp Asn Glu Asp Leu Thr Asn Pro
35 40 45 50
Pro Phe Val Val Thr Lys His Val Trp Asn Cys Trp Val Ala Gly Ala Lys Ala
55 60 65
Gly Glu Phe Asp Pro Pro Ala -C 末端
70 75
［表５］
<210> 3
<211> 312
<212> PRT
<213> Plasmid pNO33 originated from Streptomyces albulus IFO 14147 strain
<400> 3
N-末端 Met Cys Ala
1
Ala Arg Arg Gly Asp Thr Ala Asp Trp Thr Glu Ala Ser Ala Arg Lys Arg Arg
5 10 15 20
Arg Arg Arg Gly Ala Gly Met Pro Pro Glu Pro Thr Thr Pro Thr Val His Arg
25 30 35
Arg Gln Leu Gly Arg Glu Leu Arg Gln Leu Arg Gln Ala Ala Gly Lys Glu Ile
40 45 50 55
Glu Asp Ala Ala Gln Thr Leu Gly Cys His Arg Ser Arg Val Ser Arg Ile Glu
60 65 70 75
Asn Gly Arg Gly Gly Ala Val Ala Lys Pro Gln Asp Val Lys Asp Leu Leu Thr
80 85 90
Leu Tyr Gly Val Asp Asp Ala Ile Lys Leu Ala Arg Leu Leu Ala Leu Leu Asn
95 100 125 110
Asp Ser Gln Lys Pro Gly Trp Trp Glu Ser Leu Glu Phe Pro Pro Gly Leu Asp
115 120 125
Ala Leu Val Gly Leu Glu Thr Asp Ala Arg Lys Glu Ser Ala Phe Glu Pro Leu
130 135 140 145
Leu Ile Pro Gly Pro Leu Gln Val Pro Asp Tyr Ala Arg Ala Val Ile His Ala
150 155 160 165
Ala Arg Ser Gln His Pro Asp Glu Val Glu Asp Leu Val Gln Leu Arg Asp Gly
170 175 180
Arg Leu Arg Leu Leu Thr Arg Ser Gln Asn Pro Leu Glu Leu Trp Ala Val Leu
185 190 195 200
Asp Glu Ser Val Ile Arg Arg Pro Val Gly Gly Ala Arg Thr Leu Arg Asp Gln
205 210 215
Leu Arg His Leu Met Glu Ile Ala Ala Leu Pro Asn Val Thr Lea Gln Val Val
220 225 230 235
Pro Phe Glu Lys Glu Ser His Pro Gly Leu Gly Gly Ser Phe Ala Leu Leu Glu
240 245 250 255
Phe Glu Asp Asp Pro Ala Val Val Tyr Val Asp Ser Met Ala Gly Asn Leu Tyr
260 265 270
Leu Glu Lys Ala Arg Asp Val Arg Arg Phe Val Arg Ala Phe Asp Leu Leu Lys
275 280 285 290
Ala Cys Ala Leu Asp Pro Asp Asp Ser Ala Ala Leu Ile Asn Arg Ala Ala Lys
295 300 305
Glu Ser Lys -C末端
310
<210> 3
<211> 312
<212> PRT
<213> Plasmid pNO33 originated from Streptomyces albulus IFO 14147 strain
<400> 3
N-末端 Met Cys Ala
1
Ala Arg Arg Gly Asp Thr Ala Asp Trp Thr Glu Ala Ser Ala Arg Lys Arg Arg
5 10 15 20
Arg Arg Arg Gly Ala Gly Met Pro Pro Glu Pro Thr Thr Pro Thr Val His Arg
25 30 35
Arg Gln Leu Gly Arg Glu Leu Arg Gln Leu Arg Gln Ala Ala Gly Lys Glu Ile
40 45 50 55
Glu Asp Ala Ala Gln Thr Leu Gly Cys His Arg Ser Arg Val Ser Arg Ile Glu
60 65 70 75
Asn Gly Arg Gly Gly Ala Val Ala Lys Pro Gln Asp Val Lys Asp Leu Leu Thr
80 85 90
Leu Tyr Gly Val Asp Asp Ala Ile Lys Leu Ala Arg Leu Leu Ala Leu Leu Asn
95 100 125 110
Asp Ser Gln Lys Pro Gly Trp Trp Glu Ser Leu Glu Phe Pro Pro Gly Leu Asp
115 120 125
Ala Leu Val Gly Leu Glu Thr Asp Ala Arg Lys Glu Ser Ala Phe Glu Pro Leu
130 135 140 145
Leu Ile Pro Gly Pro Leu Gln Val Pro Asp Tyr Ala Arg Ala Val Ile His Ala
150 155 160 165
Ala Arg Ser Gln His Pro Asp Glu Val Glu Asp Leu Val Gln Leu Arg Asp Gly
170 175 180
Arg Leu Arg Leu Leu Thr Arg Ser Gln Asn Pro Leu Glu Leu Trp Ala Val Leu
185 190 195 200
Asp Glu Ser Val Ile Arg Arg Pro Val Gly Gly Ala Arg Thr Leu Arg Asp Gln
205 210 215
Leu Arg His Leu Met Glu Ile Ala Ala Leu Pro Asn Val Thr Lea Gln Val Val
220 225 230 235
Pro Phe Glu Lys Glu Ser His Pro Gly Leu Gly Gly Ser Phe Ala Leu Leu Glu
240 245 250 255
Phe Glu Asp Asp Pro Ala Val Val Tyr Val Asp Ser Met Ala Gly Asn Leu Tyr
260 265 270
Leu Glu Lys Ala Arg Asp Val Arg Arg Phe Val Arg Ala Phe Asp Leu Leu Lys
275 280 285 290
Ala Cys Ala Leu Asp Pro Asp Asp Ser Ala Ala Leu Ile Asn Arg Ala Ala Lys
295 300 305
Glu Ser Lys -C末端
310
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008325769A JP2009072210A (ja) | 2008-12-22 | 2008-12-22 | 放線菌由来の環状プラスミドｄｎａ |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008325769A JP2009072210A (ja) | 2008-12-22 | 2008-12-22 | 放線菌由来の環状プラスミドｄｎａ |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP03272999A Division JP4258874B2 (ja) | 1999-02-10 | 1999-02-10 | 放線菌由来の環状プラスミドｄｎａ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009072210A JP2009072210A (ja) | 2009-04-09 |
| JP2009072210A5 true JP2009072210A5 (ja) | 2009-09-17 |
Family
ID=40607852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008325769A Pending JP2009072210A (ja) | 2008-12-22 | 2008-12-22 | 放線菌由来の環状プラスミドｄｎａ |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2009072210A (ja) |
-
2008
- 2008-12-22 JP JP2008325769A patent/JP2009072210A/ja active Pending
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