JP2008547005A5 - - Google Patents

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Publication number
JP2008547005A5
JP2008547005A5 JP2008517177A JP2008517177A JP2008547005A5 JP 2008547005 A5 JP2008547005 A5 JP 2008547005A5 JP 2008517177 A JP2008517177 A JP 2008517177A JP 2008517177 A JP2008517177 A JP 2008517177A JP 2008547005 A5 JP2008547005 A5 JP 2008547005A5
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JP
Japan
Prior art keywords
mass spectrum
class
sample
digital computer
computer
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Pending
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JP2008517177A
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English (en)
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JP2008547005A (ja
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Priority claimed from PCT/US2006/023594 external-priority patent/WO2006138629A2/en
Publication of JP2008547005A publication Critical patent/JP2008547005A/ja
Publication of JP2008547005A5 publication Critical patent/JP2008547005A5/ja
Pending legal-status Critical Current

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Claims (2)

  1. a)未知サンプルのマススペクトルから得られたデータをデジタルコンピュータに投入するためのコードと、
    )分類モデルを使用して前記マススペクトルデータを処理し、生物学的状況によって特徴付けられるクラスに前記未知サンプルを分類するためのコードと、を含んでなる、コンピュータ可読媒体であって、
    前記分類モデルが、以下のステップ、すなわち、
    サンプルが有機固体材料に包埋される、化学的に架橋された分析物を含む細胞サンプルを提供するステップと、
    前記架橋された分析物の前記化学架橋の少なくとも一部を逆転して、脱架橋された分析物を形成するステップと、
    前記脱架橋された分析物を含有する前記サンプルの少なくとも一部のマススペクトルを作成するステップと、
    前記マススペクトルをデジタルコンピュータを用いて解析するステップであって、
    a)複数の細胞サンプルから得られたマススペクトルデータセットを前記デジタルコンピュータに投入するステップであって、各々のサンプルは2つ以上のクラスより構成されるクラスセットに属するクラスであるか、またはクラスに帰属される予定のものであり、各々のクラスは異なった生物学的状況により特徴付けられ、かつ各々のマススペクトルは飛行時間、質量対電荷比、若しくは飛行時間または質量対電荷比から導出された値、の関数であるシグナル強度を表すデータを含むこと、そして
    b)前記クラスセット内のクラス同士の間を識別する分類モデルを形成するステップであって、前記モデルを形成することは、分類処理および回帰ツリー処理である再帰分割処理を含む分類処理を実施するコードを執行することによって前記データセットを解析するステップを含むこと、を含んでなる前記マススペクトルを解析するステップと、を含んでなる方法によって形成されている、コンピュータ可読媒体
  2. 気相イオン分光計と、
    前記気相イオン分光計から得られたデータを処理するよう適合されたデジタルコンピュータと、
    前記デジタルコンピュータと関連付して作動する、請求項の前記コンピュータ可読媒体と、を含んでなるシステム。
JP2008517177A 2005-06-16 2006-06-16 マススペクトルを用いた化学的に架橋された細胞サンプルの分類方法 Pending JP2008547005A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69118205P 2005-06-16 2005-06-16
PCT/US2006/023594 WO2006138629A2 (en) 2005-06-16 2006-06-16 Method of classifying chemically crosslinked cellular samples using mass spectra

Related Child Applications (1)

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JP2012105945A Division JP5624079B2 (ja) 2005-06-16 2012-05-07 マススペクトルを用いた化学的に架橋された細胞サンプルの分類方法

Publications (2)

Publication Number Publication Date
JP2008547005A JP2008547005A (ja) 2008-12-25
JP2008547005A5 true JP2008547005A5 (ja) 2009-08-13

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JP2008517177A Pending JP2008547005A (ja) 2005-06-16 2006-06-16 マススペクトルを用いた化学的に架橋された細胞サンプルの分類方法
JP2012105945A Active JP5624079B2 (ja) 2005-06-16 2012-05-07 マススペクトルを用いた化学的に架橋された細胞サンプルの分類方法

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Country Status (6)

Country Link
US (1) US20110177492A1 (ja)
EP (1) EP1891433B1 (ja)
JP (2) JP2008547005A (ja)
AT (1) ATE548651T1 (ja)
AU (1) AU2006261624B2 (ja)
WO (1) WO2006138629A2 (ja)

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