JP2008546768A - 胃腸疾患を治療するためのニューロキニン受容体アンタゴニストとしての新規なアゼチジン誘導体 - Google Patents

胃腸疾患を治療するためのニューロキニン受容体アンタゴニストとしての新規なアゼチジン誘導体 Download PDF

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JP2008546768A
JP2008546768A JP2008518082A JP2008518082A JP2008546768A JP 2008546768 A JP2008546768 A JP 2008546768A JP 2008518082 A JP2008518082 A JP 2008518082A JP 2008518082 A JP2008518082 A JP 2008518082A JP 2008546768 A JP2008546768 A JP 2008546768A
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butyl
azetidin
methyl
fluorophenyl
cyano
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Japanese (ja)
Inventor
アンダーシュ・ユーハンソン
ユーハン・ユーハンソン
ウンイェ スヴェルケル・フォン
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AstraZeneca AB
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AstraZeneca AB
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2008518082A 2005-06-23 2006-06-21 胃腸疾患を治療するためのニューロキニン受容体アンタゴニストとしての新規なアゼチジン誘導体 Pending JP2008546768A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0501493 2005-06-23
PCT/SE2006/000760 WO2006137791A1 (fr) 2005-06-23 2006-06-21 Nouveaux derives d'azetidine utiles en tant qu'antagonistes des recepteurs des neurokinines employes pour le traitement des maladies gastro-intestinales

Publications (1)

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JP2008546768A true JP2008546768A (ja) 2008-12-25

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ID=37570729

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JP2008518082A Pending JP2008546768A (ja) 2005-06-23 2006-06-21 胃腸疾患を治療するためのニューロキニン受容体アンタゴニストとしての新規なアゼチジン誘導体

Country Status (4)

Country Link
EP (1) EP1899318A4 (fr)
JP (1) JP2008546768A (fr)
CN (1) CN101208327A (fr)
WO (1) WO2006137791A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009537516A (ja) * 2006-05-18 2009-10-29 アルビレオ アーベー 消化管障害の治療のための１−［（４−［ベンゾイル（メチル）アミノ］−３−（フェニル）ブチル］アゼチジン誘導体１

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR057828A1 (es) 2005-09-29 2007-12-19 Astrazeneca Ab Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica
WO2007136326A2 (fr) * 2006-05-18 2007-11-29 Astrazeneca Ab Nouveaux composés 302
WO2007136325A1 (fr) * 2006-05-18 2007-11-29 Astrazeneca Ab Dérivés de 1-[(4-[benzoyl(méthyl)amino]-3-(phényl)butyl]azétidine destinés au traitement de troubles gastro-intestinaux 2
WO2008076041A1 (fr) * 2006-12-19 2008-06-26 Albireo Ab Dérivés de l'azetidinazabicyclo [3.2.1] octane qui sont des antagonistes du récepteur de la neurokinine (nk) et utilisation de ces derniers
CN101790512A (zh) 2007-03-08 2010-07-28 阿尔比里奥公司 2-取代-3-苯基丙酸衍生物及其在炎性肠病治疗中的用途
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
JP2013518085A (ja) 2010-02-01 2013-05-20 ノバルティス アーゲー ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体
WO2011092293A2 (fr) 2010-02-01 2011-08-04 Novartis Ag Dérivés de cyclohexylamide utilisés en tant qu'antagonistes du récepteur du crf
WO2011095450A1 (fr) 2010-02-02 2011-08-11 Novartis Ag Dérivés de cyclohexylamide à titre d'antagonistes du récepteur crf
ES2731531T3 (es) * 2013-10-01 2019-11-15 Sphingotec Gmbh Método para predecir el riesgo de experimentar un episodio cardiaco adverso grave

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
GB9601202D0 (en) * 1996-01-22 1996-03-20 Pfizer Ltd Piperidones
US6365602B1 (en) * 1998-07-10 2002-04-02 Astra Zeneca Ab N-substituted naphthalene carboxamides as neurokinin-receptor antagonists
GB9922519D0 (en) * 1998-10-07 1999-11-24 Zeneca Ltd Compounds
TW200508221A (en) * 2003-06-13 2005-03-01 Astrazeneca Ab New azetidine compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009537516A (ja) * 2006-05-18 2009-10-29 アルビレオ アーベー 消化管障害の治療のための１−［（４−［ベンゾイル（メチル）アミノ］−３−（フェニル）ブチル］アゼチジン誘導体１

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CN101208327A (zh) 2008-06-25
WO2006137791A1 (fr) 2006-12-28
EP1899318A4 (fr) 2010-03-17
EP1899318A1 (fr) 2008-03-19

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