JP2008545695A - 迅速分解ポリマー - Google Patents

迅速分解ポリマー Download PDF

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Publication number
JP2008545695A
JP2008545695A JP2008513610A JP2008513610A JP2008545695A JP 2008545695 A JP2008545695 A JP 2008545695A JP 2008513610 A JP2008513610 A JP 2008513610A JP 2008513610 A JP2008513610 A JP 2008513610A JP 2008545695 A JP2008545695 A JP 2008545695A
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JP
Japan
Prior art keywords
acid
polyanhydride
carbon atoms
unbranched
divalent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2008513610A
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English (en)
Japanese (ja)
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JP2008545695A5 (enExample
Inventor
キャスリン イー． ウーリッチ，
ヨン ミ キム，
Original Assignee
ラトガーズ， ザ ステイト ユニバーシティ オブ ニュー ジャージー
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Application filed by ラトガーズ， ザ ステイト ユニバーシティ オブ ニュー ジャージー filed Critical ラトガーズ， ザ ステイト ユニバーシティ オブ ニュー ジャージー
Publication of JP2008545695A publication Critical patent/JP2008545695A/ja
Publication of JP2008545695A5 publication Critical patent/JP2008545695A5/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/775—Phenolic resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2008513610A 2005-05-23 2006-05-23 迅速分解ポリマー Withdrawn JP2008545695A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68383105P 2005-05-23 2005-05-23
PCT/US2006/019848 WO2006127667A1 (en) 2005-05-23 2006-05-23 Fast degrading polymers

Publications (2)

Publication Number Publication Date
JP2008545695A true JP2008545695A (ja) 2008-12-18
JP2008545695A5 JP2008545695A5 (enExample) 2009-07-16

Family

ID=37452349

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008513610A Withdrawn JP2008545695A (ja) 2005-05-23 2006-05-23 迅速分解ポリマー

Country Status (4)

Country Link
US (1) US8263060B2 (enExample)
EP (1) EP1898832A4 (enExample)
JP (1) JP2008545695A (enExample)
WO (1) WO2006127667A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122615B1 (en) * 1998-09-10 2006-10-17 Rutgers, The State University Of New Jersey Polyanhydrides with therapeutically useful degradation products
US6486214B1 (en) * 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
US7985415B2 (en) * 1997-09-10 2011-07-26 Rutgers, The State University Of New Jersey Medical devices employing novel polymers
US20040038948A1 (en) * 1999-12-07 2004-02-26 Uhrich Kathryn E. Therapeutic compositions and methods
AU2001278055A1 (en) * 2000-07-27 2002-02-13 Rutgers, The State University Therapeutic polyesters and polyamides
CA2654376A1 (en) * 2006-06-06 2007-12-13 Rutgers, The State University Of New Jersey Iodinated polymers
US20150005720A1 (en) 2006-07-18 2015-01-01 E Ink California, Llc Electrophoretic display
WO2008034019A2 (en) 2006-09-13 2008-03-20 Polymerix Corporation Active agents and their oligomers and polymers
WO2008128193A1 (en) 2007-04-12 2008-10-23 Rutgers, The State University Of New Jersey Biodegradable polyanhydrides with natural bioactive molecules
US8741317B2 (en) 2010-08-19 2014-06-03 Rutgers, The State University Of New Jersey Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery
US9144579B2 (en) 2012-08-17 2015-09-29 Rutgers, The State University Of New Jersey Polyesters and methods of use thereof
US20140120057A1 (en) 2012-10-25 2014-05-01 Rutgers, The State University Of New Jersey Polymers and methods thereof for wound healing
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair
US9862672B2 (en) 2013-05-29 2018-01-09 Rutgers, The State University Of New Jersey Antioxidant-based poly(anhydride-esters)
US10023521B2 (en) 2014-06-13 2018-07-17 Rutgers, The State University Of New Jersey Process and intermediates for preparing poly(anhydride-esters)
US10543162B2 (en) 2015-04-10 2020-01-28 Rutgers, The State University Of New Jersey Kojic acid polymers

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7985415B2 (en) 1997-09-10 2011-07-26 Rutgers, The State University Of New Jersey Medical devices employing novel polymers
US6486214B1 (en) 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
US6468519B1 (en) 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
US7122615B1 (en) 1998-09-10 2006-10-17 Rutgers, The State University Of New Jersey Polyanhydrides with therapeutically useful degradation products
EP1032605B1 (en) 1997-09-10 2007-11-14 Rutgers, The State University Polyanhydrides with therapeutically useful degradation products
DE60043075D1 (de) 1999-12-07 2009-11-12 Univ Rutgers Therapeutische zusammensetzungen und verfahren zur behandlung von periodontitis mit entzündunshemmenden mitteln
US6685928B2 (en) 1999-12-07 2004-02-03 Rutgers, The State University Of New Jersey Therapeutic compositions and methods
US20040038948A1 (en) 1999-12-07 2004-02-26 Uhrich Kathryn E. Therapeutic compositions and methods
WO2002009769A2 (en) 2000-07-27 2002-02-07 Rutgers, The State University Of New Jersey Therapeutic azo-compounds for drug delivery
AU2001278055A1 (en) 2000-07-27 2002-02-13 Rutgers, The State University Therapeutic polyesters and polyamides
ATE424722T1 (de) 2001-11-23 2009-03-15 Univ Rutgers Verbesserte synthese von polyanhydriden
KR20040108651A (ko) 2002-02-07 2004-12-24 루트거스, 더 스테이트 유니버시티 오브 뉴 저지 치료용 폴리에스테르 및 폴리아미드
WO2003066053A1 (en) 2002-02-07 2003-08-14 Rutgers, The State University Antibiotic polymers
US20060013851A1 (en) 2002-02-07 2006-01-19 Giroux Karen J Therapeutic polyanhydride compounds for drug delivery
AU2003251992A1 (en) 2002-07-17 2004-02-02 Rutgers, The State University Therapeutic devices for patterned cell growth
CN1717224A (zh) 2002-10-28 2006-01-04 波利梅里斯公司 治疗组合物
CN1735404A (zh) 2002-11-18 2006-02-15 波利梅里斯公司 使用新聚合物的医疗装置
US7662864B2 (en) 2003-06-04 2010-02-16 Rutgers, The State University Of New Jersey Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent
CA2527495A1 (en) 2003-06-04 2005-05-12 Polymerix Corporation High molecular weight polymers, devices and method for making and using same
US20050249697A1 (en) 2003-09-24 2005-11-10 Uhrich Kathryn E Compositions and methods for the inhibition of bone growth and resorption
CA2654376A1 (en) 2006-06-06 2007-12-13 Rutgers, The State University Of New Jersey Iodinated polymers
WO2008034019A2 (en) 2006-09-13 2008-03-20 Polymerix Corporation Active agents and their oligomers and polymers
US20100291180A1 (en) 2007-02-20 2010-11-18 Uhrich Kathryn E Nerve guidance tubes
WO2008128193A1 (en) 2007-04-12 2008-10-23 Rutgers, The State University Of New Jersey Biodegradable polyanhydrides with natural bioactive molecules
WO2009026544A1 (en) 2007-08-22 2009-02-26 Rutgers, The State University Of New Jersey Ampicillin and amoxicillin-based poly(anhydride-amides)
US8741317B2 (en) 2010-08-19 2014-06-03 Rutgers, The State University Of New Jersey Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery

Also Published As

Publication number Publication date
US20090035248A1 (en) 2009-02-05
EP1898832A1 (en) 2008-03-19
WO2006127667A1 (en) 2006-11-30
EP1898832A4 (en) 2013-01-02
US8263060B2 (en) 2012-09-11

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