JP2008536871A - 上気道の一酸化窒素浄化 - Google Patents
上気道の一酸化窒素浄化 Download PDFInfo
- Publication number
- JP2008536871A JP2008536871A JP2008506810A JP2008506810A JP2008536871A JP 2008536871 A JP2008536871 A JP 2008536871A JP 2008506810 A JP2008506810 A JP 2008506810A JP 2008506810 A JP2008506810 A JP 2008506810A JP 2008536871 A JP2008536871 A JP 2008536871A
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- JP
- Japan
- Prior art keywords
- mammal
- nitric oxide
- containing gas
- nose
- gas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title claims abstract description 520
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Images
Classifications
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- A61M2202/00—Special media to be introduced, removed or treated
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Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Critical Care (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/107,618 US7335181B2 (en) | 2000-12-26 | 2005-04-14 | Nitric oxide decontamination of the upper respiratory tract |
| PCT/US2006/014414 WO2006110923A2 (en) | 2005-04-14 | 2006-04-14 | Nitric oxide decontamination of the upper respiratory tract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008536871A true JP2008536871A (ja) | 2008-09-11 |
| JP2008536871A5 JP2008536871A5 (https=) | 2009-06-04 |
Family
ID=37087712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008506810A Pending JP2008536871A (ja) | 2005-04-14 | 2006-04-14 | 上気道の一酸化窒素浄化 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7335181B2 (https=) |
| EP (2) | EP1871448A4 (https=) |
| JP (1) | JP2008536871A (https=) |
| CN (1) | CN101198368A (https=) |
| AU (1) | AU2006235632B2 (https=) |
| BR (1) | BRPI0612213A2 (https=) |
| CA (1) | CA2605207A1 (https=) |
| MX (1) | MX2007012532A (https=) |
| WO (1) | WO2006110923A2 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7516742B2 (en) | 1999-11-24 | 2009-04-14 | Cardinal Health 207, Inc. | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing |
| US20040009238A1 (en) * | 2002-07-09 | 2004-01-15 | Chris Miller | Exogenenous nitric oxide gas (gNO) therapy in wound healing |
| US7122018B2 (en) | 2000-12-26 | 2006-10-17 | Sensormedics Corporation | Device and method for treatment of wounds with nitric oxide |
| US6432077B1 (en) | 2000-12-26 | 2002-08-13 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
| US7531133B2 (en) | 2002-09-10 | 2009-05-12 | Pulmonox Technologies Corporation | Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma |
| US9138707B2 (en) | 2002-12-10 | 2015-09-22 | Sy Kimball | Portable, nitric oxide generator |
| JP5564158B2 (ja) * | 2003-07-09 | 2014-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 亜硝酸塩によって特定の心臓血管状態を処置する方法 |
| US20080029093A1 (en) | 2004-05-11 | 2008-02-07 | Alex Stenzler | Intermittent Dosing Of Nitric Oxide Gas |
| US8518457B2 (en) | 2004-05-11 | 2013-08-27 | Pulmonox Technologies Corporation | Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant |
| US7362274B1 (en) * | 2004-07-09 | 2008-04-22 | Huan-Cheng Lien | Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna |
| US7618594B2 (en) | 2004-08-18 | 2009-11-17 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| AU2005277397B2 (en) | 2004-08-18 | 2011-08-25 | VERO Biotech LLC. | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US20070116785A1 (en) * | 2005-11-18 | 2007-05-24 | Miller Christopher C | Nitric oxide as an anti-viral agent, vaccine and vaccine adjuvant |
| US8079998B2 (en) | 2006-10-20 | 2011-12-20 | Pulmonox Technologies Corporation | Methods and devices for the delivery of therapeutic gases including nitric oxide |
| EP2237788A4 (en) * | 2007-12-27 | 2013-06-05 | Aires Pharmaceuticals Inc | COMPOUNDS FOR OBTAINING AEROSOLIZED NITRITE AND NITRIC OXIDE AND USES THEREOF |
| CA2713049C (en) | 2008-01-28 | 2017-02-28 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| US8720436B2 (en) | 2008-01-31 | 2014-05-13 | Genosys, Inc. | Nitric oxide gel apparatus and method |
| US9649467B2 (en) | 2008-01-31 | 2017-05-16 | Syk Technologies, Llc | Nitric oxide reactor and distributor apparatus and method |
| US8434475B2 (en) | 2008-01-31 | 2013-05-07 | Genosys, Inc. | Nitric oxide reactor and distributor apparatus and method |
| US8501090B2 (en) | 2008-03-24 | 2013-08-06 | Christian S. Minton | Anti-microbial gas apparatus and method |
| US8425428B2 (en) * | 2008-03-31 | 2013-04-23 | Covidien Lp | Nitric oxide measurements in patients using flowfeedback |
| US20100040703A1 (en) * | 2008-08-13 | 2010-02-18 | Chris Miller | Use of nitric oxide |
| US8607785B2 (en) | 2008-08-21 | 2013-12-17 | Geno Llc | Systems and devices for generating nitric oxide |
| US8652064B2 (en) * | 2008-09-30 | 2014-02-18 | Covidien Lp | Sampling circuit for measuring analytes |
| JP5723785B2 (ja) * | 2008-12-30 | 2015-05-27 | コーニンクレッカ フィリップス エヌ ヴェ | 被験者の気道をサポートするためのシステム、方法及び呼吸機器 |
| WO2010115168A1 (en) * | 2009-04-02 | 2010-10-07 | Breathe Technologies, Inc. | Methods, systems and devices for non-invasive open ventilation with gas delivery nozzles within an outer tube |
| EP2445508B1 (en) | 2009-06-22 | 2018-11-14 | VERO Biotech LLC | Nitric oxide therapies |
| US8685467B2 (en) | 2010-08-03 | 2014-04-01 | J. W. Randolph Miller | Nitric oxide generation, dilution, and topical application apparatus and method |
| US20150272988A1 (en) | 2012-03-07 | 2015-10-01 | Advanced Inhalation Therapies (Ait) Ltd. | Inhalation of nitric oxide for treating respiratory diseases |
| TR201707036T4 (en) * | 2012-12-04 | 2018-11-21 | Ino Therapeutics Llc | Cannula to minimize dose dilution during administration of nitric oxide |
| WO2014136111A2 (en) | 2013-03-07 | 2014-09-12 | Advanced Inhalation Therapies (Ait) Ltd. | Inhalation of nitric oxide for treating respiratory diseases |
| EP2968827B1 (en) | 2013-03-15 | 2019-02-20 | The General Hospital Corporation | Synthesis of nitric oxide gas for inhalation |
| MX370385B (es) | 2013-03-15 | 2019-12-11 | Massachusetts Gen Hospital | Sintesis inspiratoria de oxido nitrico. |
| US10517817B2 (en) | 2013-05-09 | 2019-12-31 | Syk Technologies, Llc | Deep topical systemic nitric oxide therapy apparatus and method |
| US10335567B2 (en) * | 2013-08-27 | 2019-07-02 | 12th Man Technologies, Inc. | Nitric oxide upper airway delivery system and method |
| US10226592B2 (en) | 2014-04-01 | 2019-03-12 | Mallinckrodt Hospital Product Ip Limited | Systems and method for delivery of therapeutic gas to patients in need thereof using enhanced breathing circuit gas (BCG) flow measurement |
| EP2937089A1 (en) * | 2014-04-23 | 2015-10-28 | Linde AG | Device for the treatment of, treatment of complications arising from, and/or prevention of respiratory disorders |
| RU2017102681A (ru) | 2014-06-30 | 2018-07-30 | Ориджин, Инк. | Аппарат для применения оксида азота в месте лечения |
| ES2822215T3 (es) | 2014-10-20 | 2021-04-29 | Massachusetts Gen Hospital | Sistemas y métodos de síntesis de óxido nítrico |
| ES2968200T3 (es) | 2016-01-27 | 2024-05-08 | Syk Tech Llc | Aparato y métodos de aplicación tópica de óxido nítrico |
| BR112018069582A2 (pt) | 2016-03-25 | 2019-01-22 | Massachusetts Gen Hospital | sistemas e métodos de entrega para síntese elétrica de plasma de óxido nítrico |
| CN115006049B (zh) * | 2016-07-20 | 2025-12-16 | 伊兰科美国公司 | 动物鼻内给药设备、系统以及相关方法 |
| EP3554995B1 (en) | 2016-12-14 | 2023-07-12 | Origin, Inc. | A device and method for producing high-concentration, low-temperature nitric oxide |
| MX2020010523A (es) | 2017-02-27 | 2021-02-09 | Third Pole Inc | Sistemas y metodos para generar oxido nitrico. |
| BR112019016708B1 (pt) | 2017-02-27 | 2024-01-30 | Third Pole, Inc | Sistemas de geração de óxido nítrico |
| WO2018157175A1 (en) | 2017-02-27 | 2018-08-30 | Third Pole, Inc. | Systems and methods for ambulatory generation of nitric oxide |
| WO2018183811A1 (en) | 2017-03-31 | 2018-10-04 | The General Hospital Corporation | Systems and methods for a cooled nitric oxide generator |
| US10792449B2 (en) | 2017-10-03 | 2020-10-06 | Breathe Technologies, Inc. | Patient interface with integrated jet pump |
| WO2019090080A1 (en) * | 2017-11-02 | 2019-05-09 | Ait Therapeutics, Inc. | Inhalation of nitric oxide |
| WO2019222640A1 (en) * | 2018-05-17 | 2019-11-21 | Bellerophon Therapeutics | Method and apparatus for pulsatile delivery of nitric oxide |
| WO2020232414A1 (en) | 2019-05-15 | 2020-11-19 | Third Pole, Inc. | Architectures for production of nitric oxide |
| EP3969416A4 (en) | 2019-05-15 | 2023-11-01 | Third Pole, Inc. | SYSTEMS AND DEVICES FOR GENERATING NITROGEN OXIDE |
| CN114269685A (zh) | 2019-05-15 | 2022-04-01 | 第三极股份有限公司 | 用于一氧化氮生成的电极 |
| US20210052842A1 (en) * | 2019-08-23 | 2021-02-25 | NOTA Laboratories, LLC | Nitric oxide generating systems for nasal inhalation |
| EP4069069A4 (en) | 2020-01-11 | 2024-07-03 | Third Pole, Inc. | SYSTEMS AND METHODS FOR NITROGEN OXIDE PRODUCTION WITH HUMIDITY CONTROL |
| US12017232B2 (en) | 2020-03-13 | 2024-06-25 | Julian HENLEY | Electro-ionic mask devices for improved protection from airborne biopathogens |
| EP4118385A4 (en) | 2020-03-13 | 2024-04-24 | Henley, Julian | ELECTRO-IONIC DEVICES FOR IMPROVED PROTECTION AGAINST AIR-SUSPENDED BIOPATHOGENS |
| EP4167920A4 (en) | 2020-06-18 | 2024-06-12 | Third Pole, Inc. | Systems and methods for preventing and treating infections with nitric oxide |
| WO2022082072A1 (en) | 2020-10-16 | 2022-04-21 | Third Pole, Inc. | Nitric oxide generation process controls |
| EP4405019A4 (en) | 2021-09-23 | 2025-07-16 | Third Pole Inc | SYSTEMS AND METHODS FOR PROVIDING NITRIC OXIDE |
| CN114344134A (zh) * | 2021-12-30 | 2022-04-15 | 南京诺令生物科技有限公司 | 一种内源与外源性一氧化氮相结合的鼻塞防治装置及其使用方法 |
| WO2023201363A2 (en) | 2022-04-14 | 2023-10-19 | Third Pole, Inc. | Delivery of medicinal gas in a liquid medium |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11508788A (ja) * | 1995-07-05 | 1999-08-03 | キエール アルヴィング | ベンチレータ装置 |
| WO2000030659A1 (en) * | 1998-11-23 | 2000-06-02 | Pulmonox Medical Corporation | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
| US6142147A (en) * | 1998-03-31 | 2000-11-07 | The General Hospital Corporation | Nasal delivery system for inhaled nitric oxide |
| WO2004087212A2 (en) * | 2003-04-03 | 2004-10-14 | Aga Ab | Nitric oxide in treatment of inflammation |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3036584A (en) | 1961-07-18 | 1962-05-29 | Invengineering Inc | Non-rebreathing valve for gas administration |
| US4127121A (en) | 1976-09-17 | 1978-11-28 | University Of Utah | Oxygen and anesthesia delivery and monitoring device |
| US4191952A (en) | 1978-08-25 | 1980-03-04 | N.A.D., Inc. | Low oxygen flow alarm for anesthesia systems |
| JPS55166163A (en) | 1979-06-13 | 1980-12-25 | Citizen Watch Co Ltd | Controller for anesthetic gas |
| US4328823A (en) | 1980-05-14 | 1982-05-11 | N.A.D. Inc. | Oxygen flow ratio controller for anesthesia apparatus |
| US4336798A (en) | 1980-10-06 | 1982-06-29 | Anthony V. Beran | Medical corrugated respiratory tube |
| US4442856A (en) | 1981-08-18 | 1984-04-17 | Puritan-Bennett | Oxygen regulator and alarm system for an anesthesia machine |
| DE3401923A1 (de) | 1984-01-20 | 1985-08-01 | Drägerwerk AG, 2400 Lübeck | Vorrichtung zur beimischung fluessiger narkosemittel in das dem patienten zuzufuehrende atemgas |
| US4770168A (en) | 1985-12-16 | 1988-09-13 | Tibor Rusz | Electrically controllable anesthesia vaporizer |
| US5113857A (en) * | 1990-08-27 | 1992-05-19 | Stair Dickerman | Breathing gas delivery system and holding clip member therefor |
| US5159924A (en) | 1990-10-03 | 1992-11-03 | Cegielski Michael J | Method and apparatus for selectively mixing gases |
| US5396882A (en) | 1992-03-11 | 1995-03-14 | The General Hospital Corporation | Generation of nitric oxide from air for medical uses |
| US5570683A (en) | 1990-12-05 | 1996-11-05 | The General Hospital Corporation | Methods and devices for treating pulmonary vasoconstriction and asthma |
| US5536241A (en) | 1990-12-05 | 1996-07-16 | The General Hospital Corporation | Methods and devices for relaxing smooth muscle contractions |
| EP1875917A3 (en) | 1990-12-05 | 2012-11-28 | The General Hospital Corporation | Use of NO for the treatment or prevention of reversible pulmonary vasoconstriction |
| DE4105148A1 (de) * | 1991-02-20 | 1992-08-27 | Draegerwerk Ag | Narkosemitteldosiervorrichtung |
| SE9102812L (sv) * | 1991-09-27 | 1993-01-18 | Lars Erik Gustafsson | Saett att faststaella aktuell lungfunktion samt anordning foer att indikera naemnda lungfunktion |
| US5632981A (en) | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5658565A (en) | 1994-06-24 | 1997-08-19 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Inducible nitric oxide synthase gene for treatment of disease |
| US5427797A (en) | 1993-04-06 | 1995-06-27 | Brigham And Women's Hospital | Systemic effects of nitric oxide inhalation |
| WO1995009612A1 (en) | 1993-10-07 | 1995-04-13 | Entremed, Inc. | Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents |
| US5558083A (en) * | 1993-11-22 | 1996-09-24 | Ohmeda Inc. | Nitric oxide delivery system |
| US5514204A (en) * | 1994-07-07 | 1996-05-07 | The Boc Group, Inc. | Process for the purification of nitric oxide |
| JP3089958B2 (ja) | 1994-12-06 | 2000-09-18 | 三菱自動車工業株式会社 | 電気自動車の制動制御装置 |
| US6063407A (en) | 1995-02-16 | 2000-05-16 | The General Hospital Corporation | Treatment of vascular thrombosis and restenosis with inhaled nitric oxide |
| US5823180A (en) | 1995-04-03 | 1998-10-20 | The General Hospital Corporation | Methods for treating pulmonary vasoconstriction and asthma |
| WO1996031217A1 (en) | 1995-04-04 | 1996-10-10 | Duke University | Inhibiting retroviral replication |
| ES2267141T3 (es) | 1996-04-05 | 2007-03-01 | The General Hospital Corporation | Tratamiento de una hemoglobinopatia. |
| US5765548A (en) * | 1996-05-07 | 1998-06-16 | Perry; Bryan J. | Use of nitric oxide in the treatment of exercised induced pulmonary hemorrhaging in equine |
| CA2180506C (fr) | 1996-07-04 | 2003-11-25 | Gilbert Blaise | Monoxyde d'azote inhale pour la prevention et le traitement des reactions inflammatoires |
| US6067983A (en) | 1997-09-19 | 2000-05-30 | Sensormedics Corporation | Method and apparatus for controlled flow sampling from the airway |
| CN1736502A (zh) | 1999-03-03 | 2006-02-22 | 奥普蒂诺斯公司 | 鼻传送装置 |
| US6581599B1 (en) | 1999-11-24 | 2003-06-24 | Sensormedics Corporation | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients |
| US6601580B1 (en) | 2000-06-28 | 2003-08-05 | The General Hospital Corporation | Enhancing therapeutic effectiveness of nitric oxide inhalation |
| US6668828B1 (en) * | 2000-10-16 | 2003-12-30 | Pulmonox Technologies Corporations | System and elements for managing therapeutic gas administration to a spontaneously breathing non-ventilated patient |
| US6432077B1 (en) | 2000-12-26 | 2002-08-13 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
| ZA200306564B (en) | 2001-02-26 | 2004-10-15 | Optinose As | Nasal devices. |
| US20020155164A1 (en) * | 2001-04-18 | 2002-10-24 | Curtis Figley | System and method for the prevention of infections in human patients using nitric oxide |
| SE0200300D0 (sv) * | 2002-02-01 | 2002-02-01 | Aerocrine Ab | Diagnostic device and method |
-
2005
- 2005-04-14 US US11/107,618 patent/US7335181B2/en not_active Expired - Lifetime
-
2006
- 2006-04-14 EP EP06750452A patent/EP1871448A4/en not_active Ceased
- 2006-04-14 CN CNA200680020981XA patent/CN101198368A/zh active Pending
- 2006-04-14 JP JP2008506810A patent/JP2008536871A/ja active Pending
- 2006-04-14 CA CA002605207A patent/CA2605207A1/en not_active Abandoned
- 2006-04-14 AU AU2006235632A patent/AU2006235632B2/en not_active Ceased
- 2006-04-14 WO PCT/US2006/014414 patent/WO2006110923A2/en not_active Ceased
- 2006-04-14 EP EP10156083A patent/EP2189177A3/en not_active Withdrawn
- 2006-04-14 MX MX2007012532A patent/MX2007012532A/es active IP Right Grant
- 2006-04-14 BR BRPI0612213-2A patent/BRPI0612213A2/pt not_active IP Right Cessation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11508788A (ja) * | 1995-07-05 | 1999-08-03 | キエール アルヴィング | ベンチレータ装置 |
| US6142147A (en) * | 1998-03-31 | 2000-11-07 | The General Hospital Corporation | Nasal delivery system for inhaled nitric oxide |
| WO2000030659A1 (en) * | 1998-11-23 | 2000-06-02 | Pulmonox Medical Corporation | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
| WO2004087212A2 (en) * | 2003-04-03 | 2004-10-14 | Aga Ab | Nitric oxide in treatment of inflammation |
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| CN101198368A (zh) | 2008-06-11 |
| WO2006110923A3 (en) | 2007-07-19 |
| WO2006110923A2 (en) | 2006-10-19 |
| MX2007012532A (es) | 2008-02-12 |
| EP1871448A2 (en) | 2008-01-02 |
| BRPI0612213A2 (pt) | 2010-10-26 |
| EP2189177A2 (en) | 2010-05-26 |
| CA2605207A1 (en) | 2006-10-19 |
| US20050217679A1 (en) | 2005-10-06 |
| EP1871448A4 (en) | 2008-07-16 |
| EP2189177A3 (en) | 2012-03-21 |
| AU2006235632B2 (en) | 2011-05-19 |
| AU2006235632A1 (en) | 2006-10-19 |
| US7335181B2 (en) | 2008-02-26 |
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