JP2008536855A - 炎症性腸疾患（ｉｂｄ）の治療 - Google Patents
炎症性腸疾患（ｉｂｄ）の治療 Download PDFInfo
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2020502070A (ja) * | 2016-11-30 | 2020-01-23 | ケース ウエスタン リザーブ ユニバーシティ | １５−ｐｇｄｈ阻害剤とコルチコステロイドおよび／またはｔｎｆ阻害剤との組み合わせならびにその使用 |
| JP2021511024A (ja) * | 2018-01-12 | 2021-05-06 | アムジェン インコーポレイテッド | Ｐａｃ１抗体及びその使用 |
| US11718589B2 (en) | 2017-02-06 | 2023-08-08 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase |
| US12336982B2 (en) | 2018-11-21 | 2025-06-24 | Rodeo Therapeutics Corporation | Compositions and methods of modulating short-chain dehydrogenase activity |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL146005A0 (en) | 1999-05-07 | 2002-07-25 | Genentech Inc | Treatment of autoimmune diseases with antagonists which bind to b cell surface markers |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| TR201809892T4 (tr) | 2003-11-05 | 2018-07-23 | Roche Glycart Ag | Fc reseptörüne bağlanma afinitesi ve artırılmış efektör fonksiyonu bulunan antijen bağlayan moleküller. |
| PT1912675E (pt) | 2005-07-25 | 2014-05-09 | Emergent Product Dev Seattle | Moléculas de ligaçao especificas para cd37 e especificas para cd20 |
| WO2008125903A2 (en) * | 2006-12-12 | 2008-10-23 | Chaim Sheba Medical Center | Method of inhibiting an undesired immune response |
| EP2178916B1 (en) | 2007-07-31 | 2014-12-17 | Regeneron Pharmaceuticals, Inc. | Human antibodies to human cd20 and method of using thereof |
| EP2262509A4 (en) * | 2008-03-07 | 2012-02-22 | Lawrence Bernstein | GALLIUM COMPOUNDS AND METHOD OF USE FOR THE TREATMENT OF INFLAMMATORY ENDURANCE |
| RS51975B (sr) | 2008-04-11 | 2012-02-29 | Emergent Product Development Seattle Llc. | Cd37 imunoterapeutski proizvod i njegova kombinacija sa bifunkcionalnim hemoterapeutskim sredstvom |
| US8206940B2 (en) * | 2008-05-15 | 2012-06-26 | Tufts University | Methods for diagnosis of Clostridium difficile and methods and vectors for recombinant toxin expression |
| TW201438738A (zh) | 2008-09-16 | 2014-10-16 | Genentech Inc | 治療進展型多發性硬化症之方法 |
| AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
| US8440195B2 (en) * | 2010-11-12 | 2013-05-14 | National University Corporation Chiba University | Inhibition of CD69 for treatment of inflammatory conditions |
| TWI598363B (zh) | 2011-04-21 | 2017-09-11 | 必治妥美雅史谷比公司 | 拮抗ｃｄ４０之抗體多肽 |
| WO2013090989A1 (en) * | 2011-12-22 | 2013-06-27 | Csl Limited | Method of treating inflammatory bowel disease |
| JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
| CN103149371B (zh) * | 2013-02-26 | 2015-12-23 | 哈药慈航制药股份有限公司 | 生物标记物在制备预测5-氨基水杨酸治疗溃疡性结肠炎的反馈响应药物中的应用 |
| SI3054996T1 (sl) | 2013-10-07 | 2023-11-30 | Igl Pharma, Inc. | Postopek za pripravo terapevtskih sredstev za kosti visoke čistote |
| US10435475B2 (en) * | 2014-03-07 | 2019-10-08 | Bristol-Myers Squibb Company | Method of using antibody polypeptides that antagonize CD40 to treat IBD |
| TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| PT3221359T (pt) | 2014-11-17 | 2020-06-23 | Regeneron Pharma | Métodos para o tratamento de tumores usando anticorpos biespecíficos cd3xcd20 |
| KR20200003821A (ko) * | 2017-04-07 | 2020-01-10 | 세컨드 게놈, 아이엔씨. | 상피 장벽 기능 장애 치료용 단백질 |
| WO2019018440A1 (en) | 2017-07-17 | 2019-01-24 | The Broad Institute, Inc. | HUMAN COLON CELL ATLAS IN GOOD HEALTH AND WITH HEMORRHAGIC RECTO-COLITIS |
| IL280875B2 (en) | 2018-08-31 | 2024-12-01 | Regeneron Pharma | Dosing strategy that mitigates cytokine release syndrome for cd3/c20 bispecific antibodies |
| US20220091135A1 (en) * | 2019-01-04 | 2022-03-24 | Kyoto University | Test method for ulcerative colitis and primary sclerosing cholangitis |
| CA3159053A1 (en) * | 2019-12-06 | 2021-06-10 | Sui Yi Kwok | Method of treating inflammatory bowel disease |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6893625B1 (en) * | 1986-10-27 | 2005-05-17 | Royalty Pharma Finance Trust | Chimeric antibody with specificity to human B cell surface antigen |
| IL85035A0 (en) * | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5506126A (en) * | 1988-02-25 | 1996-04-09 | The General Hospital Corporation | Rapid immunoselection cloning method |
| US4861579A (en) * | 1988-03-17 | 1989-08-29 | American Cyanamid Company | Suppression of B-lymphocytes in mammals by administration of anti-B-lymphocyte antibodies |
| US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| PT752248E (pt) * | 1992-11-13 | 2001-01-31 | Idec Pharma Corp | Aplicacao terapeutica de anticorpos quimericos e marcados radioactivamente contra antigenios de diferenciacao restrita de linfocitos b humanos para o tratamento do linfoma de celulas b |
| US7744877B2 (en) * | 1992-11-13 | 2010-06-29 | Biogen Idec Inc. | Expression and use of anti-CD20 Antibodies |
| US5595721A (en) * | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| US20010056066A1 (en) * | 1996-07-26 | 2001-12-27 | Smithkline Beecham Corporation | Method of treating immune cell mediated systemic diseases |
| US6306393B1 (en) * | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| AU8296098A (en) * | 1997-07-08 | 1999-02-08 | Board Of Regents, The University Of Texas System | Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells |
| US6528624B1 (en) * | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| US6242195B1 (en) * | 1998-04-02 | 2001-06-05 | Genentech, Inc. | Methods for determining binding of an analyte to a receptor |
| US6194551B1 (en) * | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| DE69939939D1 (de) * | 1998-08-11 | 2009-01-02 | Idec Pharma Corp | Kombinationstherapien gegen b-zell-lymphome beinhaltend die verabreichung von anti-cd20-antikörpern |
| US6224866B1 (en) * | 1998-10-07 | 2001-05-01 | Biocrystal Ltd. | Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors |
| TR200101302T2 (tr) * | 1998-11-09 | 2001-10-22 | Idec Pharmaceuticals Corporation | BMT yada PBSC transplantı alan hastalarda in vitro ya da in vivo temizleyici madde olarak kimerik anti-CD20 antikorunun kullanımı. |
| EP1035172A3 (en) * | 1999-03-12 | 2002-11-27 | Fuji Photo Film Co., Ltd. | Azomethine compound and oily magenta ink |
| KR20020020730A (ko) * | 1999-06-09 | 2002-03-15 | 오트리브 데이비스 더블유 | Ｂ-세포를 표적하는 항체를 이용한 자가면역질환의 면역치료 |
| DE19930748C2 (de) * | 1999-07-02 | 2001-05-17 | Infineon Technologies Ag | Verfahren zur Herstellung von EEPROM- und DRAM-Grabenspeicherzellbereichen auf einem Chip |
| US6100245A (en) * | 1999-09-07 | 2000-08-08 | Mcneil-Ppc, Inc. | Use of simethicone to treat ulcerative colitis |
| KR20020072277A (ko) * | 1999-11-08 | 2002-09-14 | 아이덱 파마슈티칼즈 코포레이션 | 항-ｃｄ20 항체 및/또는 화학요법 및 방사선요법과결합하여 항-ｃｄ40ｌ 항체를 이용한 ｂ세포 악성종양의치료방법 |
| US20020006404A1 (en) * | 1999-11-08 | 2002-01-17 | Idec Pharmaceuticals Corporation | Treatment of cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
| WO2001072333A1 (en) * | 2000-03-24 | 2001-10-04 | Chiron Corporation | Methods of therapy for non-hodgkin's lymphoma using a combination_of an antibody to cd20 and interleuking-2 |
| US20030185796A1 (en) * | 2000-03-24 | 2003-10-02 | Chiron Corporation | Methods of therapy for non-hodgkin's lymphoma |
| CN1981868A (zh) * | 2000-03-31 | 2007-06-20 | 拜奥根Idec公司 | 抗细胞因子抗体或拮抗剂与抗－cd20在b细胞淋巴瘤治疗中的联合应用 |
| PT2857516T (pt) * | 2000-04-11 | 2017-08-28 | Genentech Inc | Anticorpos multivalentes e utilizações dos mesmos |
| CA2405632A1 (en) * | 2000-04-25 | 2001-11-01 | Idec Pharmaceutical Corporation | Intrathecal administration of rituximab for treatment of central nervous system lymphomas |
| DE60139689D1 (de) * | 2000-06-22 | 2009-10-08 | Univ Iowa Res Found | Kombination von CpG und Antikörpern gegen CD19,CD20,CD22 oder CD40 zur Prävention oder Behandlung von Krebs. |
| KR20040023565A (ko) * | 2000-09-18 | 2004-03-18 | 아이덱 파마슈티칼즈 코포레이션 | Ｂ 세포 고갈/면역조절 항체 조합을 이용한 자가면역질환의 치료를 위한 조합 요법 |
| EP2325205A3 (en) * | 2000-12-28 | 2011-10-12 | Altus Pharmaceuticals Inc. | Crystals of whole antibodies and fragments thereof and methods for making and using them |
| US20030103971A1 (en) * | 2001-11-09 | 2003-06-05 | Kandasamy Hariharan | Immunoregulatory antibodies and uses thereof |
| EP2359849A1 (en) * | 2001-04-02 | 2011-08-24 | Genentech, Inc. | Combination therapy |
| DE60233744D1 (de) * | 2001-09-20 | 2009-10-29 | Univ Texas | Bestimmung der zirkulierenden therapeutischen antikörper, antigene sowie antigen-antikörper-komplexe mit elisa-tests |
| NZ532526A (en) * | 2001-10-25 | 2007-01-26 | Genentech Inc | Compositions comprising a glycoprotein having a Fc region |
| US20040093621A1 (en) * | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| KR101033196B1 (ko) * | 2002-02-14 | 2011-05-09 | 이뮤노메딕스, 인코오포레이티드 | 항-ｃｄ20 항체 및 그 융합 단백질 및 이들의 이용방법 |
| US20030180292A1 (en) * | 2002-03-14 | 2003-09-25 | Idec Pharmaceuticals | Treatment of B cell malignancies using anti-CD40L antibodies in combination with anti-CD20 antibodies and/or chemotherapeutics and radiotherapy |
| US20030219818A1 (en) * | 2002-05-10 | 2003-11-27 | Bohen Sean P. | Methods and compositions for determining neoplastic disease responsiveness to antibody therapy |
| PT1558648E (pt) * | 2002-10-17 | 2012-04-23 | Genmab As | Anticorpos monoclonais humanos contra cd20 |
| AR042485A1 (es) * | 2002-12-16 | 2005-06-22 | Genentech Inc | Anticuerpo humanizado que se une al cd20 humano |
| MXPA05010778A (es) * | 2003-04-09 | 2005-12-12 | Genentech Inc | Terapia para enfermedad autoinmune en un paciente con una respuesta inadecuada a un inhibidor tnf-alfa. |
| AR044388A1 (es) * | 2003-05-20 | 2005-09-07 | Applied Molecular Evolution | Moleculas de union a cd20 |
| WO2005017529A1 (en) * | 2003-07-29 | 2005-02-24 | Genentech, Inc. | Assay for human anti cd20 antibodies and uses therefor |
| US8147832B2 (en) * | 2003-08-14 | 2012-04-03 | Merck Patent Gmbh | CD20-binding polypeptide compositions and methods |
| JP2007504138A (ja) * | 2003-08-29 | 2007-03-01 | ジェネンテック・インコーポレーテッド | 眼疾患の治療法 |
| EP1696955A2 (en) * | 2003-12-19 | 2006-09-06 | Genentech, Inc. | Detection of cd20 in therapy of autoimmune diseases |
| CN1980697A (zh) * | 2004-05-05 | 2007-06-13 | 健泰科生物技术公司 | 通过使用抗cd20抗体预防自身免疫病 |
-
2006
- 2006-04-12 AR ARP060101467A patent/AR053579A1/es not_active Application Discontinuation
- 2006-04-13 BR BRPI0612321-0A patent/BRPI0612321A2/pt not_active IP Right Cessation
- 2006-04-13 JP JP2008506671A patent/JP2008536855A/ja not_active Withdrawn
- 2006-04-13 AU AU2006236816A patent/AU2006236816A1/en not_active Abandoned
- 2006-04-13 CN CNA2006800185302A patent/CN101184507A/zh active Pending
- 2006-04-13 CA CA002605020A patent/CA2605020A1/en not_active Abandoned
- 2006-04-13 US US11/403,462 patent/US20060233797A1/en not_active Abandoned
- 2006-04-13 EP EP06740918A patent/EP1871414A1/en not_active Withdrawn
- 2006-04-13 ZA ZA200708850A patent/ZA200708850B/xx unknown
- 2006-04-13 WO PCT/US2006/013780 patent/WO2006113308A1/en not_active Ceased
- 2006-04-13 MX MX2007012667A patent/MX2007012667A/es not_active Application Discontinuation
- 2006-04-13 RU RU2007142188/14A patent/RU2007142188A/ru not_active Application Discontinuation
- 2006-04-13 KR KR1020077026455A patent/KR20070122543A/ko not_active Withdrawn
- 2006-04-14 TW TW095113504A patent/TW200714291A/zh unknown
-
2007
- 2007-09-20 IL IL186151A patent/IL186151A0/en unknown
- 2007-11-14 NO NO20075845A patent/NO20075845L/no not_active Application Discontinuation
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020502070A (ja) * | 2016-11-30 | 2020-01-23 | ケース ウエスタン リザーブ ユニバーシティ | １５−ｐｇｄｈ阻害剤とコルチコステロイドおよび／またはｔｎｆ阻害剤との組み合わせならびにその使用 |
| US11690847B2 (en) | 2016-11-30 | 2023-07-04 | Case Western Reserve University | Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof |
| JP7595413B2 (ja) | 2016-11-30 | 2024-12-06 | ケース ウエスタン リザーブ ユニバーシティ | １５－ｐｇｄｈ阻害剤とコルチコステロイドおよび／またはｔｎｆ阻害剤との組み合わせならびにその使用 |
| US11718589B2 (en) | 2017-02-06 | 2023-08-08 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase |
| JP2021511024A (ja) * | 2018-01-12 | 2021-05-06 | アムジェン インコーポレイテッド | Ｐａｃ１抗体及びその使用 |
| JP2023116808A (ja) * | 2018-01-12 | 2023-08-22 | アムジェン インコーポレイテッド | Ｐａｃ１抗体及びその使用 |
| JP7339262B2 (ja) | 2018-01-12 | 2023-09-05 | アムジェン インコーポレイテッド | Ｐａｃ１抗体及びその使用 |
| US11891435B2 (en) | 2018-01-12 | 2024-02-06 | Amgen Inc. | Polynucleotides encoding monoclonal antibodies binding to human pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1) and methods of making thereof |
| US12336982B2 (en) | 2018-11-21 | 2025-06-24 | Rodeo Therapeutics Corporation | Compositions and methods of modulating short-chain dehydrogenase activity |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007012667A (es) | 2007-12-13 |
| EP1871414A1 (en) | 2008-01-02 |
| IL186151A0 (en) | 2008-01-20 |
| CA2605020A1 (en) | 2006-10-26 |
| BRPI0612321A2 (pt) | 2010-11-03 |
| NO20075845L (no) | 2008-01-14 |
| TW200714291A (en) | 2007-04-16 |
| US20060233797A1 (en) | 2006-10-19 |
| AR053579A1 (es) | 2007-05-09 |
| RU2007142188A (ru) | 2009-05-20 |
| CN101184507A (zh) | 2008-05-21 |
| KR20070122543A (ko) | 2007-12-31 |
| WO2006113308A1 (en) | 2006-10-26 |
| ZA200708850B (en) | 2009-03-25 |
| AU2006236816A1 (en) | 2006-10-26 |
| WO2006113308A8 (en) | 2007-01-18 |
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