JP2008535855A5 - - Google Patents
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- Publication number
- JP2008535855A5 JP2008535855A5 JP2008505605A JP2008505605A JP2008535855A5 JP 2008535855 A5 JP2008535855 A5 JP 2008535855A5 JP 2008505605 A JP2008505605 A JP 2008505605A JP 2008505605 A JP2008505605 A JP 2008505605A JP 2008535855 A5 JP2008535855 A5 JP 2008535855A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- ddr2
- antibody
- level
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000014509 gene expression Effects 0.000 claims 29
- 206010028980 Neoplasm Diseases 0.000 claims 27
- 201000011510 cancer Diseases 0.000 claims 26
- 238000000034 method Methods 0.000 claims 23
- 210000004027 cell Anatomy 0.000 claims 15
- 108020004999 messenger RNA Proteins 0.000 claims 10
- 239000000523 sample Substances 0.000 claims 9
- 206010027476 Metastases Diseases 0.000 claims 8
- 210000001072 colon Anatomy 0.000 claims 8
- 206010006187 Breast cancer Diseases 0.000 claims 7
- 208000026310 Breast neoplasm Diseases 0.000 claims 7
- 206010008342 Cervix carcinoma Diseases 0.000 claims 7
- 206010009944 Colon cancer Diseases 0.000 claims 7
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 7
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 7
- 206010033128 Ovarian cancer Diseases 0.000 claims 7
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 7
- 206010038389 Renal cancer Diseases 0.000 claims 7
- 208000000453 Skin Neoplasms Diseases 0.000 claims 7
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 7
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 7
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 7
- 239000002246 antineoplastic agent Substances 0.000 claims 7
- 201000007455 central nervous system cancer Diseases 0.000 claims 7
- 201000010881 cervical cancer Diseases 0.000 claims 7
- 208000029742 colonic neoplasm Diseases 0.000 claims 7
- 201000003146 cystitis Diseases 0.000 claims 7
- 206010017758 gastric cancer Diseases 0.000 claims 7
- 201000010982 kidney cancer Diseases 0.000 claims 7
- 201000007270 liver cancer Diseases 0.000 claims 7
- 208000014018 liver neoplasm Diseases 0.000 claims 7
- 201000005202 lung cancer Diseases 0.000 claims 7
- 208000020816 lung neoplasm Diseases 0.000 claims 7
- 201000001441 melanoma Diseases 0.000 claims 7
- 230000009401 metastasis Effects 0.000 claims 7
- 201000000849 skin cancer Diseases 0.000 claims 7
- 201000011549 stomach cancer Diseases 0.000 claims 7
- 206010046766 uterine cancer Diseases 0.000 claims 7
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 6
- 206010060862 Prostate cancer Diseases 0.000 claims 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 6
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 6
- 201000002528 pancreatic cancer Diseases 0.000 claims 6
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 5
- 210000001519 tissue Anatomy 0.000 claims 5
- 101150062301 Ddr2 gene Proteins 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000013610 patient sample Substances 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 230000001093 anti-cancer Effects 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 239000012216 imaging agent Substances 0.000 claims 2
- 229940127121 immunoconjugate Drugs 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 238000009739 binding Methods 0.000 claims 1
- 210000003443 bladder cell Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 150000002484 inorganic compounds Chemical class 0.000 claims 1
- 229910010272 inorganic material Inorganic materials 0.000 claims 1
- 210000003292 kidney cell Anatomy 0.000 claims 1
- 210000005265 lung cell Anatomy 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000002853 nucleic acid probe Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000005267 prostate cell Anatomy 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 210000004927 skin cell Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66986005P | 2005-04-07 | 2005-04-07 | |
| US60/669,860 | 2005-04-07 | ||
| PCT/US2006/013162 WO2006110587A2 (en) | 2005-04-07 | 2006-04-07 | Ddr2 in cancer diagnosis, detection and treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008535855A JP2008535855A (ja) | 2008-09-04 |
| JP2008535855A5 true JP2008535855A5 (cg-RX-API-DMAC7.html) | 2009-03-26 |
| JP4942219B2 JP4942219B2 (ja) | 2012-05-30 |
Family
ID=37023020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008505605A Expired - Fee Related JP4942219B2 (ja) | 2005-04-07 | 2006-04-07 | 癌の診断、検出および処置におけるｄｄｒ２ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20100068207A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1899482A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4942219B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2006235264A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2604884A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006110587A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8652472B2 (en) | 2006-12-05 | 2014-02-18 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| WO2013151677A1 (en) * | 2012-04-02 | 2013-10-10 | Broad Institute, Inc. | Ddr2 mutations in cancer |
| US9499856B2 (en) | 2012-04-02 | 2016-11-22 | The Board Institute, Inc. | DDR2 mutations in squamous cell lung cancer |
| BR112015015050B1 (pt) * | 2012-12-27 | 2023-11-14 | Quest Diagnostics Investments Incorporated | Método para diagnosticar melanoma em um indivíduo, e, método para determinar probabilidade de responder ao tratamento com um inibidor de quinase em um indivíduo com melanoma |
| KR101462329B1 (ko) | 2013-01-30 | 2014-11-21 | 중앙대학교 산학협력단 | 디스코이딘 도메인 리셉터 2의 ｊｍ2 도메인의 발현 촉진제를 유효성분으로 포함하는 암의 예방 또는 치료용 조성물 |
| EP3088521A4 (en) * | 2013-12-25 | 2017-08-02 | Saga University | Method for detecting lung cancer |
| EP4567045A1 (en) * | 2022-08-03 | 2025-06-11 | Fibro-Biomed Technology (Guangzhou) Company, Ltd. | Anti-ddr2 nano-antibody and use thereof |
| CN116027038A (zh) * | 2022-09-16 | 2023-04-28 | 菲创生物医学技术(广州)有限公司 | 盘状结构域受体2在诊断胶质瘤中的应用及相关的计算机可读介质 |
| CN116626294B (zh) * | 2022-09-20 | 2024-07-09 | 菲创生物医学技术(广州)有限公司 | 盘状结构域受体2在诊断神经退行性疾病中的应用及相关的计算机可读介质 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004002210A (ja) * | 2001-04-27 | 2004-01-08 | Takeda Chem Ind Ltd | 癌の予防・治療方法 |
| US20040116330A1 (en) * | 2001-04-27 | 2004-06-17 | Kenichiro Naito | Preventive/therapeutic method for cancer |
| US20040166490A1 (en) * | 2002-12-17 | 2004-08-26 | Morris David W. | Novel therapeutic targets in cancer |
| EP1382969A1 (en) * | 2002-07-17 | 2004-01-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Diagnosis and prevention of cancer cell invasion |
| US20040253606A1 (en) * | 2002-11-26 | 2004-12-16 | Protein Design Labs, Inc. | Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators |
| WO2004074506A2 (en) * | 2003-02-13 | 2004-09-02 | Mergen Ltd | Polynucleotide sequences and corresponding encoded polypeptides of particular secreted and membrane-bound proteins overexpressed in certain cancers |
| US7659062B2 (en) * | 2003-06-03 | 2010-02-09 | The Board of Trustee of the University of Arkansas System | Gene expression profiling of uterine serous papillary carcinomas and ovarian serous papillary tumors |
| CN1845999A (zh) * | 2003-07-02 | 2006-10-11 | 诺瓦提斯公司 | 在卵巢癌中作为预后和治疗靶标而被调控的基因 |
| WO2005005989A1 (en) * | 2003-07-11 | 2005-01-20 | F. Hoffmann-La Roche Ag | A method for predicting the metastatic potential of breast cancer |
| US20070048738A1 (en) * | 2003-07-14 | 2007-03-01 | Mayo Foundation For Medical Education And Research | Methods and compositions for diagnosis, staging and prognosis of prostate cancer |
| WO2005015236A2 (en) * | 2003-07-18 | 2005-02-17 | Roche Diagnostics Gmbh | A method for predicting the progression of adenocarcinoma |
-
2006
- 2006-04-07 CA CA002604884A patent/CA2604884A1/en not_active Abandoned
- 2006-04-07 AU AU2006235264A patent/AU2006235264A1/en not_active Withdrawn
- 2006-04-07 JP JP2008505605A patent/JP4942219B2/ja not_active Expired - Fee Related
- 2006-04-07 EP EP06749569A patent/EP1899482A2/en not_active Withdrawn
- 2006-04-07 WO PCT/US2006/013162 patent/WO2006110587A2/en not_active Ceased
- 2006-04-07 US US11/918,193 patent/US20100068207A1/en not_active Abandoned
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