JP2008534453A - 再灌流傷害および再灌流障害の処置のための置換２−チオ−３，５−ジシアノ−４−フェニル−６−アミノピリジンの使用 - Google Patents
再灌流傷害および再灌流障害の処置のための置換２−チオ−３，５−ジシアノ−４−フェニル−６−アミノピリジンの使用 Download PDFInfo
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- JP2008534453A JP2008534453A JP2008502282A JP2008502282A JP2008534453A JP 2008534453 A JP2008534453 A JP 2008534453A JP 2008502282 A JP2008502282 A JP 2008502282A JP 2008502282 A JP2008502282 A JP 2008502282A JP 2008534453 A JP2008534453 A JP 2008534453A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
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| PCT/EP2006/002263 WO2006099958A1 (en) | 2005-03-24 | 2006-03-11 | Use of substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines for the treatment of reperfusion injury and reperfusion damage |
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| EP (1) | EP1863482A1 (enExample) |
| JP (1) | JP2008534453A (enExample) |
| CA (1) | CA2602514A1 (enExample) |
| WO (1) | WO2006099958A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2013523349A (ja) * | 2010-04-08 | 2013-06-17 | ザ・ホスピタル・フォー・シック・チルドレン | 外傷性損傷に対する遠隔虚血コンディショニングの使用 |
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| DE102006042143A1 (de) * | 2006-09-08 | 2008-03-27 | Bayer Healthcare Aktiengesellschaft | Neue substituierte Bipyridin-Derivate und ihre Verwendung |
| DE102006056740A1 (de) * | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung |
| DE102006056739A1 (de) * | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Substituierte 4-Amino-3,5-dicyano-2-thiopyridine und ihre Verwendung |
| DE102007035367A1 (de) * | 2007-07-27 | 2009-01-29 | Bayer Healthcare Ag | Substituierte Aryloxazole und ihre Verwendung |
| DE102007036076A1 (de) | 2007-08-01 | 2009-02-05 | Bayer Healthcare Aktiengesellschaft | Dipeptoid-Produgs und ihre Verwendung |
| DE102007061764A1 (de) * | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Anellierte Cyanopyridine und ihre Verwendung |
| DE102007061763A1 (de) * | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Substituierte azabicyclische Verbindungen und ihre Verwendung |
| DE102008008838A1 (de) * | 2008-02-13 | 2009-08-20 | Bayer Healthcare Ag | Cycloalkoxy-substituierte 4-Phenyl-3,5-dicyanopyridine und ihre Verwendung |
| DE102008013587A1 (de) * | 2008-03-11 | 2009-09-17 | Bayer Schering Pharma Aktiengesellschaft | Heteroaryl-substituierte Dicyanopyridine und ihre Verwendung |
| JP2011520997A (ja) * | 2008-05-29 | 2011-07-21 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | ２−アルコキシ置換ジシアノピリジン類およびそれらの使用 |
| DE102008062567A1 (de) | 2008-12-16 | 2010-06-17 | Bayer Schering Pharma Aktiengesellschaft | Dipeptoid-Prodrugs und ihre Verwendung |
| DE102009006602A1 (de) * | 2009-01-29 | 2010-08-05 | Bayer Schering Pharma Aktiengesellschaft | Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs |
| WO2011123518A1 (en) | 2010-03-31 | 2011-10-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders |
| SG184353A1 (en) | 2010-03-31 | 2012-11-29 | Hospital For Sick Children | Use of remote ischemic conditioning to improve outcome after myocardial infarction |
| DE102010030688A1 (de) | 2010-06-30 | 2012-01-05 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Dicyanopyridine und ihre Verwendung |
| US20120058983A1 (en) | 2010-09-02 | 2012-03-08 | Bayer Pharma Aktiengesellschaft | Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension |
| US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| WO2014167423A2 (en) | 2013-03-15 | 2014-10-16 | The Hospital For Sick Children | Methods for modulating autophagy using remote ischemic conditioning |
| WO2014140832A2 (en) | 2013-03-15 | 2014-09-18 | The Hospital For Sick Children | Treatment of erectile dysfunction using remote ischemic conditioning |
| CA2904162A1 (en) | 2013-03-15 | 2014-12-18 | The Hospital For Sick Children | Methods relating to the use of remote ischemic conditioning |
| CA2920856C (en) | 2013-08-09 | 2026-03-03 | Ardelyx, Inc. | Ph modulating compounds for inhibiting gastrointestinal phosphate uptake |
| DE102019122497A1 (de) | 2019-08-21 | 2021-02-25 | Rheinische Friedrich-Wilhelms-Universität Bonn | Adenosin A2B-Rezeptor-Agonist zur Behandlung von Krankheiten des Muskel-Skelett-Systems |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003053441A1 (de) * | 2001-12-11 | 2003-07-03 | Bayer Healthcare Ag | Substituierte 2-thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre verwendung |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE19947154A1 (de) * | 1999-10-01 | 2001-10-04 | Bayer Ag | Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| DE10134481A1 (de) * | 2001-07-16 | 2003-01-30 | Bayer Ag | Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung |
| UA84404C2 (ru) * | 2002-06-12 | 2008-10-27 | Байоджен Айдек Ма Инк. | Способ лечения ишемического реперфузионного повреждения с помощью антагонистов рецептора аденозина |
-
2006
- 2006-03-11 JP JP2008502282A patent/JP2008534453A/ja active Pending
- 2006-03-11 US US11/887,062 patent/US20090221649A1/en not_active Abandoned
- 2006-03-11 WO PCT/EP2006/002263 patent/WO2006099958A1/en not_active Ceased
- 2006-03-11 CA CA002602514A patent/CA2602514A1/en not_active Abandoned
- 2006-03-11 EP EP06723374A patent/EP1863482A1/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003053441A1 (de) * | 2001-12-11 | 2003-07-03 | Bayer Healthcare Ag | Substituierte 2-thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre verwendung |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013523349A (ja) * | 2010-04-08 | 2013-06-17 | ザ・ホスピタル・フォー・シック・チルドレン | 外傷性損傷に対する遠隔虚血コンディショニングの使用 |
| TWI621420B (zh) * | 2010-04-08 | 2018-04-21 | 病童醫院 | 遠距缺血處理於創傷性傷害的用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006099958A1 (en) | 2006-09-28 |
| CA2602514A1 (en) | 2006-09-28 |
| US20090221649A1 (en) | 2009-09-03 |
| EP1863482A1 (en) | 2007-12-12 |
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