JP2008529711A - Medical needle with antibacterial and painless function - Google Patents

Abstract

The present invention relates to a medical needle having antibacterial and analgesic functions, and more specifically, silver (Ag) particles having a particle size of nano units are contained in the needle body or coated on the needle surface. Therefore, the present invention relates to medical needles having excellent antibacterial properties and a function of reducing pain in patients.
The medical needle of the present invention includes a needle for injection, a needle for operation, and a needle for acupuncture.
[Selection figure] None

Description

  The present invention relates to a medical needle having antibacterial and painless functions. More specifically, the needle body contains silver (Ag) particles having a nano particle size or is coated on the needle surface. The present invention relates to medical needles that have excellent antibacterial properties and have a function of reducing patient pain. The medical needle of the present invention includes a needle for injection, a needle for operation, and a needle for acupuncture.

In general, a medical needle such as an injection needle, a surgical needle, or a Chinese medicine needle is operated on a patient by a practitioner's hand. However, it is known that there are usually 200,000 to 300,000 bacteria / cm ² or more in human hands. In addition, the number of bacteria detected if hand washing and sterilization are not improved further increases, and cases of ticks or fungi have been reported in severe cases. Therefore, the current situation is that there is always a possibility that the practitioner will be infected with bacteria in the course of handling the medical needle.

  On the other hand, recently, so-called silver nano (silver) technology for making silver (Ag) particles into ultra-fine size of nano units has been used in various industrial ways. As is well known, silver nanoparticles can be processed into a sol solution or powder, are harmless to the human body, and have functions such as antibacterial, deodorizing, ultraviolet light, and electron wave blocking.

  The antibacterial action mechanism of silver nanoparticles dissolves the cell membrane of harmful bacteria and acts with intracellular enzymes to block the metabolic function of nutrients, that is, the influx and excretion of nutrients, eventually killing harmful bacteria . The smaller the size of the silver nanoparticles, the better the bactericidal and antibacterial activity. However, it has been reported to exert a strong antibacterial and bactericidal action.

  Therefore, the present invention includes a medical needle body containing silver nanoparticles or a needle surface coated with silver nanoparticles to prevent the risk of bacterial infection by the practitioner's hand, and An object of the present invention is to provide a medical needle having antibacterial and painless functions that can alleviate pain.

The figure which shows the needle | hook for various forms of Kampo (needle for acupuncture). The perspective view of a normal syringe. A photograph of a cross section of a needle coated with silver nano according to the present invention magnified 60,000 times with an electron microscope. A photograph of the side of a needle coated with silver nano according to the present invention, magnified 80,000 times with an electron microscope. The conceptual diagram which shows the treatment process of the electric needle with respect to an obese patient.

  The present invention relates to any one of medical needles selected from needles for injection, needles for operation, and needles for acupuncture. 1. A medical needle having antibacterial and painless functions, characterized in that 0.1-300 nm of nano-silver particles are coated on the needle surface with a thickness of 0.01-50 μm.

  The present invention also relates to any one of the medical needles selected from needles for injection, needles for operation, and needles for acupuncture. A medical needle having antibacterial and analgesic functions, characterized in that the nano-silver particles having a diameter of 0.1 to 300 nm are contained by 0.01 to 20% by weight of the needle weight.

Hereinafter, the present invention will be described in more detail as follows.
The medical needle according to the present invention is any one selected from a needle for injection, a needle for operation, and a needle for acupuncture, and has a particle size of 0. 1 to 300 nm of nano-silver particles are coated on the needle surface with a thickness of 0.01 to 50 μm. At this time, if the thickness of the coat is 0.01 μm or less, there is almost no silver nanocoat effect, whereas if it is 50 μm or more, the effects of the increase in cost and the increase in thickness are hardly exhibited, which is not economical. You can say that.

  In the present invention, silver nanoparticles having a particle size of 0.1 to 300 nm are used, but those having a particle size of 0.1 nm or less are still not technically feasible, and those having a particle size of 300 nm or more have a reduced antibacterial effect. There is a problem of doing.

  Furthermore, the present invention is characterized in that the needle body contains silver nanoparticles corresponding to 0.01 to 20% by weight of the needle weight. At this time, if the silver nanoparticle content is 0.01% by weight or less, the antibacterial effect is hardly exhibited, and if it is 20% by weight or more, the strength of the needle decreases, the viscosity increases, and it is inserted into the human body. There is a problem that the manufacturing cost increases.

(Mode of Invention)
FIG. 1 is a view illustrating various types of needles for acupuncture according to an embodiment of the present invention. The Kampo needle 20 includes a needle part 30 and a handle part 40. In the present invention, at least the needle part 30 contains or is coated with silver nano.

  FIG. 2 is a perspective view of a normal syringe. The syringe includes an injection needle and a cylinder, and the injection needle includes a needle portion 20 and a connecting portion 140. At this time, the needle portion 20 is usually made of metal, and the connecting portion 140 and the cylinders 30 and 120 are made of synthetic resin. In the present invention, at least the needle part 20 contains or is coated with silver nano. In order to enhance the effect of the present invention, the connecting portion 140 and the cylinders 30 and 120 other than the needle portion 20 can also contain or be coated with silver nano.

  FIG. 3 is a photograph of a cross section of a needle coated with silver nano particles by a plasma coating method magnified 60,000 times with an electron microscope. As can be seen from FIG. 3, since the coat cross section is formed very smoothly, it can be confirmed that the silver nanocoat film performs a lubricating action.

  FIG. 4 is a photograph of the side surface of a needle coated with silver nano according to the present invention, magnified 80,000 times with an electron microscope.

  In the present invention, the manufacturing process of the medical needle containing silver nano is as follows. First, the metal material constituting the needle is heated and melted, and after the silver nanoparticles are added and stirred therein, the mixture is put into a mold module and molded or injected, and the injection is slowly cooled. The medical needle of the present invention is completed.

  Next, as an embodiment of the present invention, a process for producing a medical needle coated with silver nano by an electroplating method will be described as follows. First, a cleaning process and a rinsing process for removing impurities with the needle body are performed, and a polishing process using linen is performed. Then, the cleaning process is performed again with water, immersed in a plating solution, and a DC power supply is applied. Next, the needle is put into the plating tank, and after the lower plating and the nickel plating are performed, the silver nano-solution is added, and a direct current power supply is applied, followed by drying through a washing step, thereby completing the silver nano-coat.

  Further, as another embodiment of the present invention, a process for manufacturing a medical needle coated with silver nano particles by a plasma coating method will be described as follows. First, the foreign matter on the surface of the completed needle is cleaned, rinsed, dried with a dryer to evaporate the moisture, and then the gas is injected into the plasma vacuum chamber with the needle attached to the fixed base. . Next, after performing a plasma sterilization process and a silver nano primary surface processing operation, a plasma secondary surface processing is performed, and then silver nanocoat is applied and dried to complete the silver nanocoat.

  In the following, the effectiveness of the present invention for a medical needle having antibacterial and painless functions was tested.

(Example)
5,000 stainless steel needles for injection (226 gauge), 5,000 electric needles (10.5 cm in length), and 5,000 spring needles (6 cm in length) that are currently available These were deposited by a dry sputtering method using plasma according to the following conditions to coat silver nanoparticles.

1) Location: S University Plasma Center 2) Deposition equipment: CHAMBER 850W x 850L x 700H, TARGE size: 375 x 120, TARGET 1PART 2EA (TOTAL: 6EA), MAGNET 1PART 2EA (TOTAL: 6EA), POWER DC or RF, MBP + SCREW PUMP 7000L / MIN, TURBO MOLECULAR PUMP 3000M3 / H
3) Holder: Rotating holder 4) Basic pressure: 10 ^-5 Torr or less 5) Gas used: Ar (99.99%), Oxygen (99.999%)
6) Process pressure (Ar Pressure): 1 to 10 mtorr
7) Gas flow: 9-100cc / min
8) Temperature: Room Temperature
9) Power: 10-150W
10) Silver target: purity 99.99% Ag
11) Coated body: 3 types of stainless steel needles 12) Chamber temperature: 100 ° C
13) Coat time: 60 minutes

  Under the above conditions, the deposition power was set to 120 W, and the silver nano-film was coated on the needle surface of the coated body while changing the deposition pressure. As a result of measuring changes in electrical resistivity and adhesive strength characteristics due to changes in deposition pressure, the electrical resistivity was a minimum of 5.014 μΩcm when the deposition pressure was 10 mtorr. The electrical resistivity tended to increase at the deposition pressure. In addition, the needle coated according to the above example formed a film with fine nano-particles of silver particles, and the surface thereof was extremely soft and showed uniform uniformity.

<Test Example 1> Electrical Conductivity Test An electric needle treatment for lipolysis was performed on obese patients using the silver nanocoat electric needle according to the above example. As the electric stimulator used for the electric needle treatment, STAETRON (trade name) manufactured by D Medical Co., Ltd. was used. As shown in FIG. 5, after the electric needles are punctured at 3 to 5 cm intervals at a specific obese site of a patient as shown in FIG. It was.

  On the other hand, a normal stainless steel electric needle not coated with silver nanocoat was punctured on other obese sites on the same patient, and the patient's reaction was compared by the same method. The results are shown in Table 1 below.

  From the results shown in Table 1, the silver nanoelectric needle of the present invention is superior in electrical conductivity compared to a normal stainless steel electric needle, the patient shows a remarkably fast reaction even at a low current, and the woman is more sensitive than the man. You can see that it showed a reaction. Furthermore, it can be seen that as humans get older, the body has less water and the human conductivity decreases.

<Test Example 2> Pain test (1)
When a 10 cm long needle is inserted into an obese site for 5 obese patients, both male and female, and when electricity is applied with an electric needle stimulator, the patient compares the silver nanocoat needle of the present invention with a conventional stainless steel needle. The results are shown in Table 2 below.

  As is apparent from the results in Table 2, most patients answered that there was a hard and tingling pain with the conventional stainless steel needle, whereas with the silver nanocoated needle of the present invention, pain, pain or He stated that there was little pain and it felt much softer.

<Test Example 3> Pain test (2)
The feeling of pain when inserting or withdrawing the needle and the degree of pain were investigated for the patient of Test Example 2, and the results are shown in Table 3 below.

  From the results of Table 3, the silver nanocoated needle of the present invention is soft and painless due to the lubricating action of silver when stabbed or pulled out, and there is almost no itching, swelling or allergic reaction after treatment. Recognize.

<Test Example 4> Body Lipolysis Effect Test Electrotherapy for obese patients was performed for 1 month each using the silver nanocoat needle of the present invention and a conventional stainless needle, and the weight change of the patient was compared and analyzed. Indicated.

  All the persons who performed electrical stimulation with the silver nanocoat needle of the present invention and the ear needle on the ear showed a weight loss of 10 kg or more, whereas the team subjected to electrical stimulation with a stainless steel needle was almost under 10 kg. Showed weight loss. In addition, it can be seen that the internal body fat decreased rapidly by CT imaging. As described above, the silver nano-coated needle exhibits a higher body fat removal rate than a normal stainless needle, and thus has high electrical conductivity and thermal conductivity and can easily decompose body fat. I understand.

<Test Example 5> Pain test (3)
The silver nanocoat injection needle according to the above example was used for a long-term hospitalized patient with an inflammatory disease in a general hospital, and the patient's reaction was compared with the control group. The results are shown in Table 5 below.

  From the results of Table 5, the silver nanocoat injection needle of the present invention has an antibacterial activity superior to that of a general stainless steel injection needle, and also when the needle is inserted, subcutaneous injection, intramuscular injection, vascular injection, and Ringer In any of the injections, it can be seen that the lubrication action of nano silver fine ultrafine particles significantly reduces the pain when passing through the epidermis, blood vessels and muscles of the human body or when the injection needle is withdrawn. This is because, since the silver nanoparticles are finely coated on the injection needle, damage to the skin, muscles, nerves or blood vessels, friction, and pressing are minimized during insertion.

<Test Example 6> Pain test (4)
The patient's pain and feeling when inserting or withdrawing the injection needle and the skin reaction and phenomenon after removal of the injection needle were investigated for the patient of Test Example 5, and the results are shown in Table 6.

  From the results in Table 6, most patients answered that conventional stainless needles were hard and extremely crisp when inserted, but the silver nanocoated needles of the present invention greatly reduced pain when inserted or withdrawn. In addition, it can be seen that the wound after the treatment heals much faster than in the case of the conventional injection needle, and there is no reaction such as swelling, allergy or itching and no inflammatory reaction.

  The medical needle having antibacterial and painless functions of the present invention is excellent in antibacterial, bactericidal, deodorizing and detoxifying functions, and generates anions and far-infrared rays that are favorable to the human body during treatment to promote blood circulation and endocrine activity. Anti-viral and anti-allergic effects, rapid pain relief and rapid body lipolysis. In addition, the excellent lubrication action of silver nano reduces the pain when inserting the human body, especially during the operation of an electric needle, the excellent electrical conductivity and thermal conductivity of silver nano make it possible for the needle or syringe inserted into the human body even with a weak current. It has the effect of increasing electrical conductivity and thermal conductivity.

Claims (2)

  In any one medical needle selected from needle for injection, needle for operation, and needle for acupuncture, the particle size is 0.1 to 300 nm. A medical needle having an antibacterial and analgesic function, characterized in that a nano-silver particle is coated on the needle surface with a thickness of 0.01 to 50 μm.   In any one medical needle selected from needle for injection, needle for operation, and needle for acupuncture, the particle size is 0.1 to 300 nm. A medical needle having antibacterial and analgesic functions, wherein the nano-silver particles are contained in an amount of 0.01 to 20% by weight based on 100% by weight of the needle.