JP2008529667A5 - - Google Patents

Info

Publication number

JP2008529667A5

JP2008529667A5 JP2007555266A JP2007555266A JP2008529667A5 JP 2008529667 A5 JP2008529667 A5 JP 2008529667A5 JP 2007555266 A JP2007555266 A JP 2007555266A JP 2007555266 A JP2007555266 A JP 2007555266A JP 2008529667 A5 JP2008529667 A5 JP 2008529667A5

Authority

JP

Japan

Prior art keywords

medical device

cephalotaxin

coating

medical

matrix

Prior art date

2006-02-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
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• DSRNKUZOWRFQFO-UHFFFAOYSA-N cephalotaxine Natural products COC1=CC23CCCN2CCc4cc5OCOc5cc4C3=C1O DSRNKUZOWRFQFO-UHFFFAOYSA-N 0.000 claims 9
• 238000000576 coating method Methods 0.000 claims 9
• 239000011248 coating agent Substances 0.000 claims 8
• 239000011159 matrix material Substances 0.000 claims 5
• 230000033115 angiogenesis Effects 0.000 claims 3
• 229920000642 polymer Polymers 0.000 claims 3
• 229920001222 biopolymer Polymers 0.000 claims 2
• 150000002148 esters Chemical class 0.000 claims 2
• 238000001727 in vivo Methods 0.000 claims 2
• 210000000056 organ Anatomy 0.000 claims 2
• -1 polyethylene Polymers 0.000 claims 2
• 125000000547 substituted alkyl group Chemical group 0.000 claims 2
• 229920001059 synthetic polymer Polymers 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 1
• 102000009027 Albumins Human genes 0.000 claims 1
• 108010088751 Albumins Proteins 0.000 claims 1
• 229920002101 Chitin Polymers 0.000 claims 1
• 102000008186 Collagen Human genes 0.000 claims 1
• 108010035532 Collagen Proteins 0.000 claims 1
• 229920000858 Cyclodextrin Polymers 0.000 claims 1
• 229920004934 Dacron® Polymers 0.000 claims 1
• 102000008946 Fibrinogen Human genes 0.000 claims 1
• 108010049003 Fibrinogen Proteins 0.000 claims 1
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
• 229920000544 Gore-Tex Polymers 0.000 claims 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
• 239000004677 Nylon Substances 0.000 claims 1
• 239000004698 Polyethylene Substances 0.000 claims 1
• 239000002202 Polyethylene glycol Substances 0.000 claims 1
• 229920000954 Polyglycolide Polymers 0.000 claims 1
• 239000004743 Polypropylene Substances 0.000 claims 1
• 239000004793 Polystyrene Substances 0.000 claims 1
• 229920002334 Spandex Polymers 0.000 claims 1
• 230000002491 angiogenic effect Effects 0.000 claims 1
• 230000004888 barrier function Effects 0.000 claims 1
• MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
• 150000001720 carbohydrates Chemical class 0.000 claims 1
• 229920001436 collagen Polymers 0.000 claims 1
• 229960005188 collagen Drugs 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 229920001577 copolymer Polymers 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940012952 fibrinogen Drugs 0.000 claims 1
• 229960002442 glucosamine Drugs 0.000 claims 1
• 229920000669 heparin Polymers 0.000 claims 1
• 229960002897 heparin Drugs 0.000 claims 1
• HYFHYPWGAURHIV-UHFFFAOYSA-N homoharringtonine Natural products C1=C2CCN3CCCC43C=C(OC)C(OC(=O)C(O)(CCCC(C)(C)O)CC(=O)OC)C4C2=CC2=C1OCO2 HYFHYPWGAURHIV-UHFFFAOYSA-N 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 150000002632 lipids Chemical class 0.000 claims 1
• 239000000463 material Substances 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 229920001778 nylon Polymers 0.000 claims 1
• HYFHYPWGAURHIV-JFIAXGOJSA-N omacetaxine mepesuccinate Chemical compound C1=C2CCN3CCC[C@]43C=C(OC)[C@@H](OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)[C@H]4C2=CC2=C1OCO2 HYFHYPWGAURHIV-JFIAXGOJSA-N 0.000 claims 1
• 229960002230 omacetaxine mepesuccinate Drugs 0.000 claims 1
• 210000002220 organoid Anatomy 0.000 claims 1
• 229920000747 poly(lactic acid) Polymers 0.000 claims 1
• 229920000515 polycarbonate Polymers 0.000 claims 1
• 239000004417 polycarbonate Substances 0.000 claims 1
• 229920000573 polyethylene Polymers 0.000 claims 1
• 229920001223 polyethylene glycol Polymers 0.000 claims 1
• 239000005020 polyethylene terephthalate Substances 0.000 claims 1
• 229920001155 polypropylene Polymers 0.000 claims 1
• 229920002223 polystyrene Polymers 0.000 claims 1
• 229920002635 polyurethane Polymers 0.000 claims 1
• 239000004814 polyurethane Substances 0.000 claims 1
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
• 238000007493 shaping process Methods 0.000 claims 1
• 239000004759 spandex Substances 0.000 claims 1
• 239000003356 suture material Substances 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• 230000029663 wound healing Effects 0.000 claims 1