JP2008529486A5 - - Google Patents
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- Publication number
- JP2008529486A5 JP2008529486A5 JP2007553650A JP2007553650A JP2008529486A5 JP 2008529486 A5 JP2008529486 A5 JP 2008529486A5 JP 2007553650 A JP2007553650 A JP 2007553650A JP 2007553650 A JP2007553650 A JP 2007553650A JP 2008529486 A5 JP2008529486 A5 JP 2008529486A5
- Authority
- JP
- Japan
- Prior art keywords
- hla
- peptide
- molecule
- fragment
- epitope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 30
- 239000012634 fragment Substances 0.000 claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 101001100327 Homo sapiens RNA-binding protein 45 Proteins 0.000 claims 7
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 7
- 102100038823 RNA-binding protein 45 Human genes 0.000 claims 7
- 206010015108 Epstein-Barr virus infection Diseases 0.000 claims 5
- 108010028921 Lipopeptides Proteins 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 230000003902 lesion Effects 0.000 claims 5
- 230000001613 neoplastic effect Effects 0.000 claims 5
- 101150059079 EBNA1 gene Proteins 0.000 claims 4
- 102100040482 HLA class II histocompatibility antigen, DR beta 3 chain Human genes 0.000 claims 4
- 102100028640 HLA class II histocompatibility antigen, DR beta 5 chain Human genes 0.000 claims 4
- 108010093013 HLA-DR1 Antigen Proteins 0.000 claims 4
- 108700037339 HLA-DR13 antigen Proteins 0.000 claims 4
- 108010063970 HLA-DR15 antigen Proteins 0.000 claims 4
- 108010064885 HLA-DR3 Antigen Proteins 0.000 claims 4
- 108010046732 HLA-DR4 Antigen Proteins 0.000 claims 4
- 108010001041 HLA-DR7 Antigen Proteins 0.000 claims 4
- 108010061311 HLA-DRB3 Chains Proteins 0.000 claims 4
- 108010016996 HLA-DRB5 Chains Proteins 0.000 claims 4
- 101001136981 Homo sapiens Proteasome subunit beta type-9 Proteins 0.000 claims 4
- 101150113776 LMP1 gene Proteins 0.000 claims 4
- 102100035764 Proteasome subunit beta type-9 Human genes 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 4
- 108020001507 fusion proteins Proteins 0.000 claims 4
- 102000037865 fusion proteins Human genes 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102100028636 HLA class II histocompatibility antigen, DR beta 4 chain Human genes 0.000 claims 3
- 108010059234 HLA-DPw4 antigen Proteins 0.000 claims 3
- -1 HLA-DR11 Proteins 0.000 claims 3
- 108010040960 HLA-DRB4 Chains Proteins 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 230000027455 binding Effects 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 1
- 101100532584 Clostridium perfringens (strain 13 / Type A) sspC1 gene Proteins 0.000 claims 1
- 101150034979 DRB3 gene Proteins 0.000 claims 1
- 101150082328 DRB5 gene Proteins 0.000 claims 1
- 101100095550 Homo sapiens SENP7 gene Proteins 0.000 claims 1
- 108700020134 Human immunodeficiency virus 1 nef Proteins 0.000 claims 1
- 101100278514 Oryza sativa subsp. japonica DRB2 gene Proteins 0.000 claims 1
- 101100117569 Oryza sativa subsp. japonica DRB6 gene Proteins 0.000 claims 1
- 101100119347 Plasmodium falciparum EXP-1 gene Proteins 0.000 claims 1
- 101150098865 SSP2 gene Proteins 0.000 claims 1
- 102100031406 Sentrin-specific protease 7 Human genes 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- AEMBWNDIEFEPTH-UHFFFAOYSA-N n-tert-butyl-n-ethylnitrous amide Chemical compound CCN(N=O)C(C)(C)C AEMBWNDIEFEPTH-UHFFFAOYSA-N 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0501198 | 2005-02-07 | ||
| FR0501198A FR2881746B1 (fr) | 2005-02-07 | 2005-02-07 | Epitopes t cd4+des antigenes de latence de type i et ii du virus epstein-barr aptes a etre reconnus par la majorite des individus de la population caucasienne et leurs applications |
| PCT/FR2006/000229 WO2006082313A2 (fr) | 2005-02-07 | 2006-02-02 | Epitopes t cd4+ des antigenes de latence de type i et ii du virus epstein-barr aptes a etre reconnus par la majorite des individus db la population caucasienne et leurs applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008529486A JP2008529486A (ja) | 2008-08-07 |
| JP2008529486A5 true JP2008529486A5 (cg-RX-API-DMAC10.html) | 2009-02-26 |
| JP4972562B2 JP4972562B2 (ja) | 2012-07-11 |
Family
ID=35116028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007553650A Expired - Fee Related JP4972562B2 (ja) | 2005-02-07 | 2006-02-02 | 白人個体群の個体の大多数により認識され得るエプスタイン−バーウイルスのｉ型及びｉｉ型潜伏期抗原のｔｃｄ４＋エピトープ、及びその適用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20090130134A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1861418B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP4972562B2 (cg-RX-API-DMAC10.html) |
| AT (1) | ATE455791T1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2596929C (cg-RX-API-DMAC10.html) |
| DE (1) | DE602006011859D1 (cg-RX-API-DMAC10.html) |
| FR (1) | FR2881746B1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2006082313A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995011699A1 (en) * | 1993-10-29 | 1995-05-04 | The Trustees Of Boston University | Physiologically stable compositions of butyric acid, and butyric acid salts and derivatives as anti-neoplastic agents |
| AU774861B2 (en) * | 1998-02-11 | 2004-07-08 | Douglas V Faller | Compositions and methods for the treatment of cystic fibrosis |
| FR2830940B1 (fr) | 2001-10-17 | 2007-06-15 | Commissariat Energie Atomique | Procede de selection de ligands d'hla-dp4 et ses applications |
| GB0710529D0 (en) | 2007-06-01 | 2007-07-11 | Circassia Ltd | Vaccine |
| BRPI0815395A2 (pt) | 2007-08-15 | 2015-02-10 | Circassia Ltd | Composição, vetor, produto, formulação farmacêutica, me´todo in vitro para determinar se as células t reconhecem um polipeptídeo, e, método in vitro para determinar se um indivíduo se encontra ou está em risco de uma condição. |
| WO2010105112A1 (en) * | 2009-03-11 | 2010-09-16 | Hemaquest Pharmaceuticals, Inc. | Detection of short-chain fatty acids in biological samples |
| US20110086869A1 (en) | 2009-09-24 | 2011-04-14 | The Trustees Of Boston University | Methods for treating viral disorders |
| WO2011072086A1 (en) | 2009-12-08 | 2011-06-16 | Hemaquest Pharmaceuticals, Inc. | Methods and low dose regimens for treating red blood cell disorders |
| US20110245154A1 (en) | 2010-03-11 | 2011-10-06 | Hemaquest Pharmaceuticals, Inc. | Methods and Compositions for Treating Viral or Virally-Induced Conditions |
| CA3132353A1 (en) | 2012-05-08 | 2013-11-14 | The Johns Hopkins University | Methods and compositions for infusion of transiently engrafting, selected populations of allogeneic lymphocytes to treat cancer |
| CN105555756B (zh) | 2013-06-28 | 2018-12-07 | 奥克兰联合服务有限公司 | 氨基酸缀合物和肽缀合物及缀合方法 |
| CA2971677A1 (en) | 2014-12-23 | 2016-06-30 | Margaret Anne Brimble | Amino acid and peptide conjugates and uses thereof |
| TW201735952A (zh) | 2016-02-26 | 2017-10-16 | 瑪格蕾特 安 布萊博 | 胺基酸及肽共軛物以及共軛過程 |
| EP4650005A3 (en) | 2016-07-15 | 2026-01-28 | Viracta Subsidiary, Inc. | Histone deacetylase inhibitors for use in immunotherapy |
| CN110809716B (zh) | 2017-02-12 | 2023-07-07 | 百欧恩泰美国公司 | 基于hla的方法和组合物及其用途 |
| KR20200101394A (ko) | 2017-12-20 | 2020-08-27 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 엡스타인-바 바이러스 항원 구축물 |
| CA3124457A1 (en) * | 2018-12-21 | 2020-06-25 | Biontech Us Inc. | Method and systems for prediction of hla class ii-specific epitopes and characterization of cd4+ t cells |
| TWI853940B (zh) | 2019-05-31 | 2024-09-01 | 美商維拉克塔股份有限公司 | 以組蛋白去乙醯酶抑制劑治療病毒相關癌症之方法 |
| IL295241B1 (en) * | 2020-02-10 | 2026-06-01 | Univ Johns Hopkins | Cancer immunotherapy using allogeneic and tumor-specific T-cell and CD4 cell transfusions |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040157780A1 (en) * | 1993-11-29 | 2004-08-12 | Epimmune Inc. | CTL inducing peptides from c-erb2 (HER-2/neu) |
| WO1996002563A1 (en) * | 1994-07-13 | 1996-02-01 | Cornell Research Foundation, Inc. | Epstein-barr virus nuclear antigen 1 protein and its expression and recovery |
| US20020141995A1 (en) * | 1997-06-10 | 2002-10-03 | Irvin Charles G. | Method for treatment of inflammatory disease |
| CA2392456A1 (en) * | 1999-11-24 | 2001-05-31 | Oklahoma Medical Research Foundation | Assays and therapies for latent viral infection |
| EP1229043A1 (en) * | 2001-01-30 | 2002-08-07 | Cyto-Barr B.V. | Peptides derived from Epstein Barr virus (EBV) proteins LMP1, LMP2 and BARF1 antibody reagents reactive therewith |
| GB0214528D0 (en) * | 2002-06-24 | 2002-08-07 | Univ Aberdeen | Materials and methods for induction of immune tolerance |
| AU2003246485A1 (en) * | 2002-07-16 | 2004-02-02 | Affinium Pharmaceuticals, Inc. | Interactions of the epstein-barr virus protein ebna1, and uses thereof |
| WO2004041849A1 (en) * | 2002-11-07 | 2004-05-21 | The Council Of The Queensland Institute Of Medical Research | Epstein barr virus peptide epitopes, polyepitopes and delivery system therefor |
| US20040141995A1 (en) * | 2002-12-10 | 2004-07-22 | Rongfu Wang | MHC class I-restricted and MHC class II-restricted EBNA1 peptides |
-
2005
- 2005-02-07 FR FR0501198A patent/FR2881746B1/fr not_active Expired - Fee Related
-
2006
- 2006-02-02 EP EP06709221A patent/EP1861418B1/fr not_active Expired - Lifetime
- 2006-02-02 CA CA2596929A patent/CA2596929C/fr not_active Expired - Fee Related
- 2006-02-02 WO PCT/FR2006/000229 patent/WO2006082313A2/fr not_active Ceased
- 2006-02-02 JP JP2007553650A patent/JP4972562B2/ja not_active Expired - Fee Related
- 2006-02-02 AT AT06709221T patent/ATE455791T1/de not_active IP Right Cessation
- 2006-02-02 DE DE602006011859T patent/DE602006011859D1/de not_active Expired - Lifetime
- 2006-02-02 US US11/883,814 patent/US20090130134A1/en not_active Abandoned
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