JP2008526995A - アミン・ポリマーで改質されたナノ粒子状キャリヤ - Google Patents

アミン・ポリマーで改質されたナノ粒子状キャリヤ Download PDF

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Publication number
JP2008526995A
JP2008526995A JP2007551426A JP2007551426A JP2008526995A JP 2008526995 A JP2008526995 A JP 2008526995A JP 2007551426 A JP2007551426 A JP 2007551426A JP 2007551426 A JP2007551426 A JP 2007551426A JP 2008526995 A JP2008526995 A JP 2008526995A
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Prior art keywords
core
particles
composition
colloid
polymer
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Japanese (ja)
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JP2008526995A5 (enExample
Inventor
フランシス ブリングリー,ジョセフ
アレックス チャオ,ティエチェン
ウィリアム ハーダー,ジョン
ウンダー,アンドリュー
エム. ヒューイット,ジェイムズ
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ケアストリーム ヘルス,インコーポレイティド
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Priority claimed from US11/036,814 external-priority patent/US7541017B2/en
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Publication of JP2008526995A publication Critical patent/JP2008526995A/ja
Publication of JP2008526995A5 publication Critical patent/JP2008526995A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032Methine dyes, e.g. cyanine dyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043Fluorescein, used in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0063Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0063Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/04Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • CCHEMISTRY; METALLURGY
    • C03GLASS; MINERAL OR SLAG WOOL
    • C03CCHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C12/00Powdered glass; Bead compositions
    • CCHEMISTRY; METALLURGY
    • C03GLASS; MINERAL OR SLAG WOOL
    • C03CCHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C17/00Surface treatment of glass, not in the form of fibres or filaments, by coating
    • C03C17/28Surface treatment of glass, not in the form of fibres or filaments, by coating with organic material
    • C03C17/32Surface treatment of glass, not in the form of fibres or filaments, by coating with organic material with synthetic or natural resins
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991Coated
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991Coated
    • Y10T428/2993Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991Coated
    • Y10T428/2998Coated including synthetic resin or polymer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pigments, Carbon Blacks, Or Wood Stains (AREA)
JP2007551426A 2005-01-14 2006-01-13 アミン・ポリマーで改質されたナノ粒子状キャリヤ Withdrawn JP2008526995A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/036,814 US7541017B2 (en) 2003-07-18 2005-01-14 Amine polymer-modified nanoparticulate carriers
US11/165,849 US20060293396A1 (en) 2005-01-14 2005-06-24 Amine polymer-modified nanoparticulate carriers
PCT/US2006/001332 WO2006076636A1 (en) 2005-01-14 2006-01-13 Amine polymer-modified nanoparticulate carriers

Publications (2)

Publication Number Publication Date
JP2008526995A true JP2008526995A (ja) 2008-07-24
JP2008526995A5 JP2008526995A5 (enExample) 2009-03-05

Family

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JP2007551426A Withdrawn JP2008526995A (ja) 2005-01-14 2006-01-13 アミン・ポリマーで改質されたナノ粒子状キャリヤ

Country Status (5)

Country Link
US (2) US20060293396A1 (enExample)
EP (1) EP1836252A1 (enExample)
JP (1) JP2008526995A (enExample)
CN (1) CN101193962A (enExample)
WO (1) WO2006076636A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011046288A3 (en) * 2009-10-17 2011-07-07 Snu R&Db Foundation Icg doped silica nanoparticles for biological imaging and preparation method thereof
JP2012206253A (ja) * 2005-10-14 2012-10-25 Vive Nano Inc 複合ナノ粒子、ナノ粒子およびその生成方法

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2872061B1 (fr) * 2004-06-23 2007-04-27 Toulouse Inst Nat Polytech Composition solide divisee formee de grains a depot metallique atomique continu et son procede d'obtention
US20070292688A1 (en) * 2005-08-18 2007-12-20 Eastman Kodak Company Silylamine modified nanoparticulate carriers
US8203132B2 (en) 2005-09-08 2012-06-19 Carestream Health, Inc. Apparatus and method for imaging ionizing radiation
US20080095699A1 (en) * 2006-10-20 2008-04-24 Shiying Zheng Imaging contrast agents using nanoparticles
US8660631B2 (en) 2005-09-08 2014-02-25 Bruker Biospin Corporation Torsional support apparatus and method for craniocaudal rotation of animals
JP2010506027A (ja) 2006-10-11 2010-02-25 フジフィルム・イメイジング・カラランツ・リミテッド 方法、組成物及びインク
US7833960B2 (en) 2006-12-15 2010-11-16 International Flavors & Fragrances Inc. Encapsulated active material containing nanoscaled material
US20080193766A1 (en) 2007-02-13 2008-08-14 Northern Nanotechnologies Control of Transport to and from Nanoparticle Surfaces
US7645318B2 (en) 2008-05-07 2010-01-12 Vive Nano, Inc. Producing nanoparticles using nanoscale polymer templates
US20100208348A1 (en) * 2008-08-22 2010-08-19 Carestream Health, Inc. Tunable spectral filtration device
US8216961B2 (en) * 2008-08-27 2012-07-10 Korea University Research And Business Foundation Nanoparticles including metal oxide having catalytic activity
IT1398194B1 (it) 2008-10-22 2013-02-14 Univ Degli Studi Torino Cianina funzionalizzata con braccio di legame silanico, procedimento per la sua preparazione e suoi usi
CN101696282B (zh) * 2009-10-23 2012-06-20 蚌埠市瑞洁科技有限责任公司 用于橡胶胶乳制品的补强填充剂及其制备方法与用途
WO2011109214A2 (en) * 2010-03-01 2011-09-09 University Of Florida Research Foundation, Inc. Near-ir indocyanine green doped multimodal silica nanoparticles and methods for making the same
US20110306148A1 (en) * 2010-06-14 2011-12-15 Siemens Healthcare Diagnostics Inc. Composition for use as an assay reagent
WO2012032524A1 (en) 2010-09-09 2012-03-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Near infrared fluorescent particles and uses thereof
WO2012178184A2 (en) * 2011-06-23 2012-12-27 Children's Hospital Los Angeles Removable protective shell for imaging agents and bioactive substances
GB201121288D0 (en) 2011-12-12 2012-01-25 Univ Muenster Wilhelms Functionalised silicon nanoparticles
CN102516566B (zh) * 2011-12-16 2013-12-25 华中科技大学 一种生物可降解聚合物纳米粒子的制备方法
KR20130084091A (ko) 2012-01-16 2013-07-24 삼성전자주식회사 화상형성장치
WO2014063662A1 (en) * 2012-10-26 2014-05-01 Lee, Huai Cheng Core-shell particles, preparation process thereof, and composition containing the same
CN104383891B (zh) * 2014-12-02 2017-01-11 河海大学 一种壳聚糖-拟态薄水铝掺杂磁性吸附剂及其制备方法
WO2016149378A1 (en) * 2015-03-16 2016-09-22 Pdx Pharmaceuticals, Llc Cross-linked polymer modified nanoparticles
CN105181662B (zh) * 2015-08-24 2018-04-03 西北大学 一种定性检测负载在多糖微球中功能纳米颗粒分布的方法
CN109174033B (zh) * 2018-08-27 2021-07-27 南京师范大学 一种可安全进出红细胞的血液铅离子清除剂及其制备方法和应用
CN110075767B (zh) * 2019-04-18 2021-08-27 天津大学 长余辉水凝胶及制备方法
KR20220035161A (ko) 2019-07-12 2022-03-21 오레곤 헬스 앤드 사이언스 유니버시티 유사분열 키나제 억제제 및 면역 체크포인트 억제제의 공동-전달을 위한 치료 구축물
US20220249389A1 (en) 2019-07-12 2022-08-11 Oregon Health & Science University Immunotherapeutic constructs and methods of their use

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3796634A (en) * 1970-03-19 1974-03-12 Us Health Education & Welfare Insolubilized biologically active enzymes
US4904411A (en) * 1986-04-25 1990-02-27 Ceramics Process Systems Corp. Highly loaded, pourable suspensions of particulate materials
US5248772A (en) * 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
US6159445A (en) * 1994-07-20 2000-12-12 Nycomed Imaging As Light imaging contrast agents
ATE187079T1 (de) * 1994-09-27 1999-12-15 Nycomed Imaging As Kontrastmittel
US6388788B1 (en) * 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
KR20000048167A (ko) * 1998-12-24 2000-07-25 미우라 유이찌, 쓰지 가오루 양이온성 수지 변성 실리카 분산액 및 그 제조 방법
US6530944B2 (en) * 2000-02-08 2003-03-11 Rice University Optically-active nanoparticles for use in therapeutic and diagnostic methods
US6548264B1 (en) * 2000-05-17 2003-04-15 University Of Florida Coated nanoparticles
WO2002028660A2 (en) * 2000-10-02 2002-04-11 Kimberly-Clark Worldwide, Inc. Nanoparticle based inks and methods of making the same
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
DE10120802A1 (de) * 2001-04-27 2002-10-31 Basf Ag Verfahren zur Herstellung von gecoateten Nanopartikeln
US7081489B2 (en) * 2001-08-09 2006-07-25 Florida State University Research Foundation Polymeric encapsulation of nanoparticles
AU2003207438A1 (en) * 2002-01-02 2003-07-24 Visen Medical, Inc. Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
US20040101822A1 (en) * 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
US20050014851A1 (en) * 2003-07-18 2005-01-20 Eastman Kodak Company Colloidal core-shell assemblies and methods of preparation
US8137548B2 (en) * 2003-10-17 2012-03-20 Zirchrom Separations, Inc. Chelator-modified inorganic oxide particles

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012206253A (ja) * 2005-10-14 2012-10-25 Vive Nano Inc 複合ナノ粒子、ナノ粒子およびその生成方法
USRE45848E1 (en) 2005-10-14 2016-01-19 Vive Crop Protection Inc. Composite nanoparticles, nanoparticles and methods for producing same
WO2011046288A3 (en) * 2009-10-17 2011-07-07 Snu R&Db Foundation Icg doped silica nanoparticles for biological imaging and preparation method thereof
KR101177173B1 (ko) * 2009-10-17 2012-08-24 서울대학교산학협력단 생물학적 이미징을 위한 icg 도핑된 실리카 나노파티클 및 이의 제조방법

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Publication number Publication date
WO2006076636A1 (en) 2006-07-20
US20060293396A1 (en) 2006-12-28
US20080241266A1 (en) 2008-10-02
CN101193962A (zh) 2008-06-04
EP1836252A1 (en) 2007-09-26

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