JP2008526945A5 - - Google Patents
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- JP2008526945A5 JP2008526945A5 JP2007550874A JP2007550874A JP2008526945A5 JP 2008526945 A5 JP2008526945 A5 JP 2008526945A5 JP 2007550874 A JP2007550874 A JP 2007550874A JP 2007550874 A JP2007550874 A JP 2007550874A JP 2008526945 A5 JP2008526945 A5 JP 2008526945A5
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- JP
- Japan
- Prior art keywords
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- hydrogen
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- hydroxyl
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 24
- 229910052739 hydrogen Inorganic materials 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 16
- 238000004519 manufacturing process Methods 0.000 claims 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 230000004054 inflammatory process Effects 0.000 claims 7
- -1 3-trifluoromethylphenyl Chemical group 0.000 claims 6
- YHVUVJYEERGYNU-UHFFFAOYSA-N 4',8-Di-Me ether-5,7,8-Trihydroxy-3-(4-hydroxybenzyl)-4-chromanone Natural products COC1(C)CC(O)OC(C)C1O YHVUVJYEERGYNU-UHFFFAOYSA-N 0.000 claims 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 6
- AJSDVNKVGFVAQU-BIIVOSGPSA-N cladinose Chemical compound O=CC[C@@](C)(OC)[C@@H](O)[C@H](C)O AJSDVNKVGFVAQU-BIIVOSGPSA-N 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 125000002950 monocyclic group Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 239000001301 oxygen Substances 0.000 claims 6
- 229910052717 sulfur Chemical group 0.000 claims 6
- 239000011593 sulfur Chemical group 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 4
- 230000006052 T cell proliferation Effects 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 230000016396 cytokine production Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 230000002757 inflammatory effect Effects 0.000 claims 4
- 150000002576 ketones Chemical class 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 108010002350 Interleukin-2 Proteins 0.000 claims 3
- 102000000743 Interleukin-5 Human genes 0.000 claims 3
- 108010002616 Interleukin-5 Proteins 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 210000003714 granulocyte Anatomy 0.000 claims 3
- 210000000265 leukocyte Anatomy 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 2
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 2
- 125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 claims 2
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 2
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 2
- 125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- 108010002352 Interleukin-1 Proteins 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- 108090001007 Interleukin-8 Proteins 0.000 claims 2
- 206010029379 Neutrophilia Diseases 0.000 claims 2
- 206010030113 Oedema Diseases 0.000 claims 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 2
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 206010006451 bronchitis Diseases 0.000 claims 2
- 206010062952 diffuse panbronchiolitis Diseases 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 2
- 230000000770 proinflammatory effect Effects 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 206010006448 Bronchiolitis Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009137 Chronic sinusitis Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010011732 Cyst Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000000592 Nasal Polyps Diseases 0.000 claims 1
- 206010031252 Osteomyelitis Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 206010044248 Toxic shock syndrome Diseases 0.000 claims 1
- 231100000650 Toxic shock syndrome Toxicity 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 230000002052 anaphylactic effect Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 201000009267 bronchiectasis Diseases 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000027157 chronic rhinosinusitis Diseases 0.000 claims 1
- 208000031513 cyst Diseases 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 230000008595 infiltration Effects 0.000 claims 1
- 238000001764 infiltration Methods 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 208000016366 nasal cavity polyp Diseases 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 230000000414 obstructive effect Effects 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 0 CC[C@]([C@](C)([C@@]([C@@](C)N(C[C@](C)CC(C)(*)[C@@]([C@@](C)C(*)(*)[C@]1(C)*)O[C@@](C2)O[C@](C)C[C@@]2N(C)C)C(N*)=*)O)O)OC1=O Chemical compound CC[C@]([C@](C)([C@@]([C@@](C)N(C[C@](C)CC(C)(*)[C@@]([C@@](C)C(*)(*)[C@]1(C)*)O[C@@](C2)O[C@](C)C[C@@]2N(C)C)C(N*)=*)O)O)OC1=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64442505P | 2005-01-14 | 2005-01-14 | |
| PCT/IB2006/001088 WO2006097849A1 (en) | 2005-01-14 | 2006-01-13 | 9a-carbamoyl and thiocarbamoyl azalides with anti-inflammatory activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008526945A JP2008526945A (ja) | 2008-07-24 |
| JP2008526945A5 true JP2008526945A5 (enExample) | 2009-02-26 |
Family
ID=36688005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007550874A Withdrawn JP2008526945A (ja) | 2005-01-14 | 2006-01-13 | 抗炎症活性を有する９ａ−カルバモイルおよびチオカルバモイルアザライド |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20080200403A1 (enExample) |
| EP (1) | EP1846003A1 (enExample) |
| JP (1) | JP2008526945A (enExample) |
| WO (1) | WO2006097849A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2548578T3 (es) | 2007-12-27 | 2015-10-19 | Kissei Pharmaceutical Co., Ltd. | Monosebacato de un derivado de pirazol |
| KR102057249B1 (ko) | 2017-11-03 | 2019-12-18 | 이상두 | 피부 염증성 질환의 예방 및 치료용 스파 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU198913B (en) * | 1987-09-03 | 1989-12-28 | Pliva Pharm & Chem Works | Process for producing 10-dihydro-10-deoxo-11-aza-erythronolide a-derivatives and pharmaceutical compositions containing them as active components |
| HRP931480B1 (en) * | 1993-12-08 | 1997-08-31 | Sour Pliva | 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A |
| HRP20010301A2 (en) * | 2001-04-27 | 2001-12-31 | Pliva D D | New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases |
| CN100577681C (zh) * | 2002-07-08 | 2010-01-06 | 葛兰素伊斯特拉齐瓦基森塔萨格勒布公司 | 用于治疗炎性疾病和病症的新化合物、组合物和方法 |
| ITMI20022292A1 (it) * | 2002-10-29 | 2004-04-30 | Zambon Spa | 9a-azalidi ad attivita' antiinfiammatoria. |
| HRP20030381B1 (en) * | 2003-05-14 | 2007-05-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A |
-
2006
- 2006-01-13 WO PCT/IB2006/001088 patent/WO2006097849A1/en not_active Ceased
- 2006-01-13 US US11/813,870 patent/US20080200403A1/en not_active Abandoned
- 2006-01-13 JP JP2007550874A patent/JP2008526945A/ja not_active Withdrawn
- 2006-01-13 EP EP06755845A patent/EP1846003A1/en not_active Withdrawn
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