JP2008523076A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008523076A5 JP2008523076A5 JP2007545600A JP2007545600A JP2008523076A5 JP 2008523076 A5 JP2008523076 A5 JP 2008523076A5 JP 2007545600 A JP2007545600 A JP 2007545600A JP 2007545600 A JP2007545600 A JP 2007545600A JP 2008523076 A5 JP2008523076 A5 JP 2008523076A5
- Authority
- JP
- Japan
- Prior art keywords
- immunomodulatory
- combination
- tlr7 agonist
- tlr7
- immunomodulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000002519 immonomodulatory effect Effects 0.000 claims 5
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 claims 3
- WSIZDLIFQIDDKA-UHFFFAOYSA-N 3h-imidazo[4,5-h]quinolin-2-amine Chemical group C1=CC=NC2=C(NC(N)=N3)C3=CC=C21 WSIZDLIFQIDDKA-UHFFFAOYSA-N 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- JWLAFIOGOBJKEP-UHFFFAOYSA-N 1h-imidazo[4,5-b][1,8]naphthyridin-2-amine Chemical compound C1=CN=C2NC3=NC(N)=NC3=CC2=C1 JWLAFIOGOBJKEP-UHFFFAOYSA-N 0.000 claims 1
- KXQPVJRJUJJWQJ-UHFFFAOYSA-N 1h-imidazo[4,5-b]pyridin-2-amine Chemical compound C1=CN=C2NC(N)=NC2=C1 KXQPVJRJUJJWQJ-UHFFFAOYSA-N 0.000 claims 1
- VIIYMKOWLFKDHA-UHFFFAOYSA-N 2,3,3a,4-tetrahydro-1h-imidazo[4,5-b][1,8]naphthyridin-2-amine Chemical compound N1C2=NC=CC=C2C=C2C1NC(N)N2 VIIYMKOWLFKDHA-UHFFFAOYSA-N 0.000 claims 1
- BZBQNDWAMYFNIE-UHFFFAOYSA-N 2,3,3a,4-tetrahydro-1h-imidazo[4,5-h]quinolin-2-amine Chemical compound C1C=C2C=CC=NC2=C2C1NC(N)N2 BZBQNDWAMYFNIE-UHFFFAOYSA-N 0.000 claims 1
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 1
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 1
- QOOXNMYDCWUEHW-UHFFFAOYSA-N [1,3]oxazolo[4,5-h]quinolin-2-amine Chemical compound C1=CC=NC2=C(OC(N)=N3)C3=CC=C21 QOOXNMYDCWUEHW-UHFFFAOYSA-N 0.000 claims 1
- YUDGNSDTJOJYBS-UHFFFAOYSA-N [1,3]oxazolo[5,4-b][1,8]naphthyridin-2-amine Chemical compound C1=CN=C2N=C(OC(N)=N3)C3=CC2=C1 YUDGNSDTJOJYBS-UHFFFAOYSA-N 0.000 claims 1
- YSQNOJMVGVZJRJ-UHFFFAOYSA-N [1,3]oxazolo[5,4-b]pyridin-2-amine Chemical compound C1=CN=C2OC(N)=NC2=C1 YSQNOJMVGVZJRJ-UHFFFAOYSA-N 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
Claims (3)
- ＴＬＲ７アゴニスト；および
ＴＬＲ７アゴニストによって誘導される少なくとも１種のＴＬＲ７介在性生物活性を低下させるのに有効な量の免疫調節性オリゴヌクレオチド
を含む免疫調節性の合剤。 - 免疫調節性オリゴヌクレオチドが、ＣｐＧオリゴジヌクレオチドを含む、請求項１に記載の免疫調節性の合剤。
- ＴＬＲ７アゴニストが、イミダゾキノリンアミン、テトラヒドロイミダゾキノリンアミン、イミダゾピリジンアミン、１，２−架橋イミダゾキノリンアミン、６，７−縮合シクロアルキルイミダゾピリジンアミン、イミダゾナフチリジンアミン、テトラヒドロイミダゾナフチリジンアミン、オキサゾロキノリンアミン、チアゾロキノリンアミン、オキサゾロピリジンアミン、チアゾロピリジンアミン、オキサゾロナフチリジンアミン、またはチアゾロナフチリジンアミンを含む、請求項１に記載の免疫調節性の合剤。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63414504P | 2004-12-08 | 2004-12-08 | |
| PCT/US2005/044306 WO2006063072A2 (en) | 2004-12-08 | 2005-12-08 | Immunomodulatory compositions, combinations and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008523076A JP2008523076A (ja) | 2008-07-03 |
| JP2008523076A5 true JP2008523076A5 (ja) | 2009-02-05 |
Family
ID=36578531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007545600A Withdrawn JP2008523076A (ja) | 2004-12-08 | 2005-12-08 | 免疫調節性の組成物、合剤、および方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20110070575A1 (ja) |
| EP (1) | EP1819364A4 (ja) |
| JP (1) | JP2008523076A (ja) |
| WO (1) | WO2006063072A2 (ja) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040265351A1 (en) | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| MXPA06001674A (es) | 2003-08-12 | 2006-05-12 | 3M Innovative Properties Co | Compuestos que contienen imidazo hidroxilamina-sustituidos. |
| EP1658076B1 (en) | 2003-08-27 | 2013-03-06 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted imidazoquinolines |
| EP1660026A4 (en) | 2003-09-05 | 2008-07-16 | 3M Innovative Properties Co | TREATMENT FOR CD5 + B CELL LYMPHOMA |
| CA2540598C (en) | 2003-10-03 | 2013-09-24 | 3M Innovative Properties Company | Pyrazolopyridines and analogs thereof |
| AU2004278014B2 (en) | 2003-10-03 | 2011-04-28 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| EP1685129A4 (en) | 2003-11-14 | 2008-10-22 | 3M Innovative Properties Co | OXIMSUBSTITUTED IMIDAZORING CONNECTIONS |
| CN1906192A (zh) | 2003-11-14 | 2007-01-31 | 3M创新有限公司 | 羟胺取代的咪唑环化合物 |
| AR046781A1 (es) | 2003-11-25 | 2005-12-21 | 3M Innovative Properties Co | Derivados de imidazoquinolinas. composiciones farmaceuticas. |
| WO2005066170A1 (en) | 2003-12-29 | 2005-07-21 | 3M Innovative Properties Company | Arylalkenyl and arylalkynyl substituted imidazoquinolines |
| CA2551399A1 (en) | 2003-12-30 | 2005-07-21 | 3M Innovative Properties Company | Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides |
| WO2005094531A2 (en) | 2004-03-24 | 2005-10-13 | 3M Innovative Properties Company | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
| WO2005123080A2 (en) | 2004-06-15 | 2005-12-29 | 3M Innovative Properties Company | Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
| WO2006065280A2 (en) | 2004-06-18 | 2006-06-22 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods |
| US8541438B2 (en) | 2004-06-18 | 2013-09-24 | 3M Innovative Properties Company | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
| WO2006038923A2 (en) | 2004-06-18 | 2006-04-13 | 3M Innovative Properties Company | Aryl substituted imidazonaphthyridines |
| WO2006009826A1 (en) | 2004-06-18 | 2006-01-26 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
| EP1831221B1 (en) | 2004-12-30 | 2012-08-08 | 3M Innovative Properties Company | Substituted chiral fused 1,2 imidazo 4,5-c ring compounds |
| AU2005322898B2 (en) | 2004-12-30 | 2011-11-24 | 3M Innovative Properties Company | Chiral fused (1,2)imidazo(4,5-c) ring compounds |
| JP2008530022A (ja) | 2005-02-04 | 2008-08-07 | コーリー ファーマシューティカル グループ，インコーポレイテッド | 免疫反応調節物質を含む水性ゲル処方物 |
| CA2597324C (en) | 2005-02-09 | 2015-06-30 | Coley Pharmaceutical Group, Inc. | Alkyloxy substituted thiazoloquinolines and thiazolonaphthyridines |
| AU2006213746A1 (en) | 2005-02-11 | 2006-08-17 | Coley Pharmaceutical Group, Inc. | Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods |
| WO2006091647A2 (en) | 2005-02-23 | 2006-08-31 | Coley Pharmaceutical Group, Inc. | Method of preferentially inducing the biosynthesis of interferon |
| US7943636B2 (en) | 2005-04-01 | 2011-05-17 | 3M Innovative Properties Company | 1-substituted pyrazolo (3,4-C) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases |
| JP2008535832A (ja) | 2005-04-01 | 2008-09-04 | コーリー ファーマシューティカル グループ，インコーポレイテッド | ピラゾロピリジン−１，４−ジアミン、およびそのアナログ |
| WO2007047396A2 (en) | 2005-10-12 | 2007-04-26 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| AU2006311871B2 (en) * | 2005-11-04 | 2011-03-03 | 3M Innovative Properties Company | Hydroxy and alkoxy substituted 1H-imidazoquinolines and methods |
| US8951528B2 (en) | 2006-02-22 | 2015-02-10 | 3M Innovative Properties Company | Immune response modifier conjugates |
| WO2008008432A2 (en) | 2006-07-12 | 2008-01-17 | Coley Pharmaceutical Group, Inc. | Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods |
| US8377898B2 (en) * | 2006-10-12 | 2013-02-19 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| EP2207787B1 (en) * | 2007-11-06 | 2014-11-12 | AdiuTide Pharmaceuticals GmbH | Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties |
| AU2009286247A1 (en) * | 2008-08-29 | 2010-03-04 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Delivery of a CD40 agonist to a tumor draining lymph node of a subject |
| MX2011003625A (es) | 2008-10-06 | 2011-05-31 | Idera Pharmaceuticals Inc | Uso de inhibidores de receptores tipo toll en la prevencion y tratamiento de hipercolesterolemia e hiperlipidemia y enfermedades relacionadas con esto. |
| US8637479B2 (en) * | 2008-11-04 | 2014-01-28 | Index Pharmaceuticals Ab | Compounds and methods for the treatment of inflammatory diseases of the CNS |
| CN105294684B (zh) | 2010-08-17 | 2018-04-06 | 3M创新有限公司 | 脂质化免疫反应调节剂化合物的组合物、制剂及方法 |
| CN107012149A (zh) | 2010-11-19 | 2017-08-04 | 艾德拉药物股份有限公司 | 调控基于toll‑样受体的免疫应答的免疫调节寡核苷酸(iro)化合物 |
| CA2838158C (en) | 2011-06-03 | 2019-07-16 | 3M Innovative Properties Company | Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom |
| EP3153180A1 (en) | 2011-06-03 | 2017-04-12 | 3M Innovative Properties Company | Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom |
| WO2013162828A1 (en) * | 2012-04-27 | 2013-10-31 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Use of cpg oligonucleotides co-formulated with an antibiotic to accelarate wound healing |
| EP2674170B1 (en) | 2012-06-15 | 2014-11-19 | Invivogen | Novel compositions of TLR7 and/or TLR8 agonists conjugated to lipids |
| EP2732825B1 (en) | 2012-11-19 | 2015-07-01 | Invivogen | Conjugates of a TLR7 and/or TLR8 agonist and a TLR2 agonist |
| EP2769738B1 (en) | 2013-02-22 | 2016-07-20 | Invivogen | Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists |
| CN107537035A (zh) * | 2017-08-30 | 2018-01-05 | 北京恩元华生物科技有限公司 | 复合佐剂及含复合佐剂的狂犬疫苗及其制备方法和应用 |
| EP3728255B1 (en) | 2017-12-20 | 2022-01-26 | 3M Innovative Properties Company | Amide substituted imidazo[4,5-c]quinoline compounds with a branched chain linking group for use as an immune response modifier |
| US11504425B2 (en) | 2019-02-26 | 2022-11-22 | Wayne State University | Amphiphilic oligodeoxynucleotide conjugates as adjuvant enhancers |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3314941A (en) * | 1964-06-23 | 1967-04-18 | American Cyanamid Co | Novel substituted pyridodiazepins |
| US4006237A (en) * | 1973-10-11 | 1977-02-01 | Beecham Group Limited | Tetrahydrocarbostyril derivatives for the prophylaxis of asthma, hayfever and rhinitis |
| US4381344A (en) * | 1980-04-25 | 1983-04-26 | Burroughs Wellcome Co. | Process for producing deoxyribosides using bacterial phosphorylase |
| US4563525A (en) * | 1983-05-31 | 1986-01-07 | Ici Americas Inc. | Process for preparing pyrazolopyridine compounds |
| US4563821A (en) * | 1984-10-31 | 1986-01-14 | Saunders Archery Co. | Peep sight for compound bow |
| HU197019B (en) * | 1985-11-12 | 1989-02-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing thiqzolo (4,5-c) quinoline derivatives and pharmaceuticals comprising same |
| CA1287061C (en) * | 1986-06-27 | 1991-07-30 | Roche Holding Ltd. | Pyridine ethanolamine derivatives |
| US5500228A (en) * | 1987-05-26 | 1996-03-19 | American Cyanamid Company | Phase separation-microencapsulated pharmaceuticals compositions useful for alleviating dental disease |
| US5736553A (en) * | 1988-12-15 | 1998-04-07 | Riker Laboratories, Inc. | Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo 4,5-C!quinolin-4-amine |
| US4988815A (en) * | 1989-10-26 | 1991-01-29 | Riker Laboratories, Inc. | 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines |
| US5389640A (en) * | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| US5187288A (en) * | 1991-05-22 | 1993-02-16 | Molecular Probes, Inc. | Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis |
| US5268376A (en) * | 1991-09-04 | 1993-12-07 | Minnesota Mining And Manufacturing Company | 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| US5378848A (en) * | 1992-02-12 | 1995-01-03 | Shionogi & Co., Ltd. | Condensed imidazopyridine derivatives |
| US5395937A (en) * | 1993-01-29 | 1995-03-07 | Minnesota Mining And Manufacturing Company | Process for preparing quinoline amines |
| KR100341341B1 (ko) * | 1993-07-15 | 2002-11-25 | 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 | 이미다조[4,5-c]피리딘-4-아민 |
| US5648516A (en) * | 1994-07-20 | 1997-07-15 | Minnesota Mining And Manufacturing Company | Fused cycloalkylimidazopyridines |
| JPH07163368A (ja) * | 1993-12-15 | 1995-06-27 | Hayashibara Biochem Lab Inc | 組換えｄｎａとその組換えｄｎａを含む形質転換体 |
| WO1996002555A1 (en) * | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US5612377A (en) * | 1994-08-04 | 1997-03-18 | Minnesota Mining And Manufacturing Company | Method of inhibiting leukotriene biosynthesis |
| US5482936A (en) * | 1995-01-12 | 1996-01-09 | Minnesota Mining And Manufacturing Company | Imidazo[4,5-C]quinoline amines |
| US5861268A (en) * | 1996-05-23 | 1999-01-19 | Biomide Investment Limited Partnership | Method for induction of tumor cell apoptosis with chemical inhibitors targeted to 12-lipoxygenase |
| US5741908A (en) * | 1996-06-21 | 1998-04-21 | Minnesota Mining And Manufacturing Company | Process for reparing imidazoquinolinamines |
| AU698419B2 (en) * | 1996-07-03 | 1998-10-29 | Dainippon Sumitomo Pharma Co., Ltd. | A novel purine derivative |
| HUP9904665A3 (en) * | 1996-10-25 | 2000-11-28 | Minnesota Mining And Mfg Co Sa | Immune response modifier compounds for treatment of th2 mediated and related diseases |
| US5939090A (en) * | 1996-12-03 | 1999-08-17 | 3M Innovative Properties Company | Gel formulations for topical drug delivery |
| FR2761557B1 (fr) * | 1997-03-28 | 1999-04-30 | Alsthom Cge Alcatel | Procede de transmission sur une pluralite de supports de transmission, a repartition dynamique des donnees, et emetteur et terminal correspondants |
| ATE370740T1 (de) * | 1997-05-20 | 2007-09-15 | Ottawa Health Research Inst | Verfahren zur herstellung von nukleinsäurekonstrukten |
| UA67760C2 (uk) * | 1997-12-11 | 2004-07-15 | Міннесота Майнінг Енд Мануфакчурінг Компані | Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки |
| TW572758B (en) * | 1997-12-22 | 2004-01-21 | Sumitomo Pharma | Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives |
| US6110929A (en) * | 1998-07-28 | 2000-08-29 | 3M Innovative Properties Company | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof |
| US6518280B2 (en) * | 1998-12-11 | 2003-02-11 | 3M Innovative Properties Company | Imidazonaphthyridines |
| US20020058674A1 (en) * | 1999-01-08 | 2002-05-16 | Hedenstrom John C. | Systems and methods for treating a mucosal surface |
| US6756382B2 (en) * | 1999-06-10 | 2004-06-29 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
| US6541485B1 (en) * | 1999-06-10 | 2003-04-01 | 3M Innovative Properties Company | Urea substituted imidazoquinolines |
| HU229310B1 (en) * | 1999-10-29 | 2013-10-28 | Nektar Therapeutics | Dry powder compositions having improved dispersivity |
| US6376669B1 (en) * | 1999-11-05 | 2002-04-23 | 3M Innovative Properties Company | Dye labeled imidazoquinoline compounds |
| US20040023870A1 (en) * | 2000-01-21 | 2004-02-05 | Douglas Dedera | Methods of therapy and diagnosis using targeting of cells that express toll-like receptor proteins |
| GB0001704D0 (en) * | 2000-01-25 | 2000-03-15 | Glaxo Group Ltd | Protein |
| US6894060B2 (en) * | 2000-03-30 | 2005-05-17 | 3M Innovative Properties Company | Method for the treatment of dermal lesions caused by envenomation |
| DE10029580C1 (de) * | 2000-06-15 | 2002-01-10 | Ferton Holding Sa | Vorrichtung zum Entfernen von Körpersteinen mit einem intrakorporalen Lithotripter |
| GB0023008D0 (en) * | 2000-09-20 | 2000-11-01 | Glaxo Group Ltd | Improvements in vaccination |
| US6545017B1 (en) * | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Urea substituted imidazopyridines |
| UA74852C2 (en) * | 2000-12-08 | 2006-02-15 | 3M Innovative Properties Co | Urea-substituted imidazoquinoline ethers |
| US6545016B1 (en) * | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Amide substituted imidazopyridines |
| US6677347B2 (en) * | 2000-12-08 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamido ether substituted imidazoquinolines |
| AU2002232498B2 (en) * | 2000-12-08 | 2006-05-04 | 3M Innovative Properties Company | Screening method for identifying compounds that selectively induce interferon alpha |
| US6677348B2 (en) * | 2000-12-08 | 2004-01-13 | 3M Innovative Properties Company | Aryl ether substituted imidazoquinolines |
| US6525064B1 (en) * | 2000-12-08 | 2003-02-25 | 3M Innovative Properties Company | Sulfonamido substituted imidazopyridines |
| US6664265B2 (en) * | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Amido ether substituted imidazoquinolines |
| US20020182274A1 (en) * | 2001-03-21 | 2002-12-05 | Kung-Ming Lu | Methods for inhibiting cancer growth, reducing infection and promoting general health with a fermented soy extract |
| ATE463505T1 (de) * | 2001-04-20 | 2010-04-15 | Inst Systems Biology | Toll-ähnlichen-rezeptor-5-liganden und verwendungsverfahren |
| WO2003094836A2 (en) * | 2001-10-12 | 2003-11-20 | University Of Iowa Research Foundation | Methods and products for enhancing immune responses using imidazoquinoline compounds |
| EP1455700A4 (en) * | 2001-11-16 | 2007-02-14 | 3M Innovative Properties Co | METHODS AND COMPOSITIONS RELATED TO MRI COMPOUNDS AND TO TOLL-TYPE RECEPTOR (TLR) PATHWAYS |
| US20050009858A1 (en) * | 2001-11-17 | 2005-01-13 | Martinez-Colon Maria I | Imiquimod therapies |
| US6677349B1 (en) * | 2001-12-21 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| US6525028B1 (en) * | 2002-02-04 | 2003-02-25 | Corixa Corporation | Immunoeffector compounds |
| EP2368431A1 (en) * | 2002-04-04 | 2011-09-28 | Coley Pharmaceutical GmbH | Immunostimulatory G,U-containing oligoribonucleotides |
| EP1513524A4 (en) * | 2002-06-07 | 2008-09-03 | 3M Innovative Properties Co | WITH ETHER SUBSTITUTED IMIDAZOPYRIDINE |
| MXPA05000893A (es) * | 2002-07-23 | 2005-09-30 | Biogal Gyogyszergyar | Preparacion de 1h-imidazo[4,5-c]quinolin-4-aminas a traves de compuestos intermedios 1h-imidazo [4,5-c] quinolin-4-ftalimida. |
| SI1539752T1 (sl) * | 2002-07-26 | 2007-08-31 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Priprava 1H-imidazo(4,5-c)kinolin-4-aminov preko novih imidazo(4,5-c)kinolin-4-ciano in 1H-imidazo(4,5-c)kinolin-4- karboksamidnih intermediatov |
| AU2003300184B8 (en) * | 2002-12-30 | 2009-12-03 | 3M Innovative Properties Company | Immunostimulatory combinations |
| US7163947B2 (en) * | 2003-03-07 | 2007-01-16 | 3M Innovative Properties Company | 1-Amino 1H-imidazoquinolines |
| EP1603476A4 (en) * | 2003-03-13 | 2010-01-13 | 3M Innovative Properties Co | PROCESS FOR REMOVING TATTOO |
| US20050032829A1 (en) * | 2003-06-06 | 2005-02-10 | 3M Innovative Properties Company | Process for imidazo[4,5-c]pyridin-4-amines |
| WO2005016275A2 (en) * | 2003-08-05 | 2005-02-24 | 3M Innovative Properties Company | Formulations containing an immune response modifier |
| MXPA06001674A (es) * | 2003-08-12 | 2006-05-12 | 3M Innovative Properties Co | Compuestos que contienen imidazo hidroxilamina-sustituidos. |
| EP1660122A4 (en) * | 2003-08-25 | 2007-10-24 | 3M Innovative Properties Co | IMMUNOSTIMULATORY COMBINATIONS AND TREATMENTS |
| EP1658076B1 (en) * | 2003-08-27 | 2013-03-06 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted imidazoquinolines |
| EP1660026A4 (en) * | 2003-09-05 | 2008-07-16 | 3M Innovative Properties Co | TREATMENT FOR CD5 + B CELL LYMPHOMA |
| ATE465742T1 (de) * | 2003-09-05 | 2010-05-15 | Anadys Pharmaceuticals Inc | Tlr7-liganden zur behandlung von hepatitis c |
| JP2007505629A (ja) * | 2003-09-17 | 2007-03-15 | スリーエム イノベイティブ プロパティズ カンパニー | Ｔｌｒ遺伝子発現の選択的調節 |
| US20090075980A1 (en) * | 2003-10-03 | 2009-03-19 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and Analogs Thereof |
| AU2004278014B2 (en) * | 2003-10-03 | 2011-04-28 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
| US20050239733A1 (en) * | 2003-10-31 | 2005-10-27 | Coley Pharmaceutical Gmbh | Sequence requirements for inhibitory oligonucleotides |
| EP1685129A4 (en) * | 2003-11-14 | 2008-10-22 | 3M Innovative Properties Co | OXIMSUBSTITUTED IMIDAZORING CONNECTIONS |
| AR046781A1 (es) * | 2003-11-25 | 2005-12-21 | 3M Innovative Properties Co | Derivados de imidazoquinolinas. composiciones farmaceuticas. |
| WO2005066170A1 (en) * | 2003-12-29 | 2005-07-21 | 3M Innovative Properties Company | Arylalkenyl and arylalkynyl substituted imidazoquinolines |
| CA2551399A1 (en) * | 2003-12-30 | 2005-07-21 | 3M Innovative Properties Company | Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides |
| US20080015184A1 (en) * | 2004-06-14 | 2008-01-17 | 3M Innovative Properties Company | Urea Substituted Imidazopyridines, Imidazoquinolines, and Imidazonaphthyridines |
| AU2006213746A1 (en) * | 2005-02-11 | 2006-08-17 | Coley Pharmaceutical Group, Inc. | Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods |
| US8093390B2 (en) * | 2005-02-11 | 2012-01-10 | 3M Innovative Properties Company | Substituted fused [1,2]imidazo[4,5-C] ring compounds and methods |
| WO2006091647A2 (en) * | 2005-02-23 | 2006-08-31 | Coley Pharmaceutical Group, Inc. | Method of preferentially inducing the biosynthesis of interferon |
| US8178677B2 (en) * | 2005-02-23 | 2012-05-15 | 3M Innovative Properties Company | Hydroxyalkyl substituted imidazoquinolines |
| WO2006091567A2 (en) * | 2005-02-23 | 2006-08-31 | Coley Pharmaceutical Group, Inc. | Hydroxyalkyl substituted imidazoquinoline compounds and methods |
| US8138173B2 (en) * | 2005-04-01 | 2012-03-20 | 3M Innovative Properties Company | Pyrazolo[3,4-C]quinolines, pyrazolo[3,4-C]naphthyridines, analogs thereof, and methods |
| WO2008008432A2 (en) * | 2006-07-12 | 2008-01-17 | Coley Pharmaceutical Group, Inc. | Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods |
-
2005
- 2005-12-08 WO PCT/US2005/044306 patent/WO2006063072A2/en active Application Filing
- 2005-12-08 US US11/720,862 patent/US20110070575A1/en not_active Abandoned
- 2005-12-08 EP EP05853268A patent/EP1819364A4/en not_active Withdrawn
- 2005-12-08 JP JP2007545600A patent/JP2008523076A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008523076A5 (ja) | ||
| JP2008523084A5 (ja) | ||
| NO2017005I1 (no) | Human pappilomavirus vaksine [type 6, 11, 16, 18, 31, 33, 45, 52, 58] | |
| IL245489A0 (en) | New 1-aryl-3-azabicyclo[0.1.3]hexanes, their preparation and their use for the treatment of neuropsychotic disorders | |
| JP2007520565A5 (ja) | ||
| EP1888765A4 (en) | METHOD AND COMPOSITIONS FOR DIAGNOSIS OF VENOUS THROMBOEMBOLIC ILLNESSES | |
| JP2010538767A5 (ja) | ||
| WO2007073478A8 (en) | Genemap of the human genes associated with crohn's disease | |
| EP1929043A4 (en) | GENETIC CARD OF HUMAN GENES ASSOCIATED WITH CROHN'S DISEASE | |
| FR2887548B1 (fr) | Derives de 4,5-diarylpyrrole, leur preparation et leur application en therapeutique | |
| HK1118804A1 (en) | Novel unsaturated fatty hydroxy acid derivatives and the dermocosmetologic use thereof | |
| FR2899254B1 (fr) | Tete de douchette avec dosage de savons, sels et similaires. | |
| EP1841747A4 (en) | DERIVATIVES OF OXAZOLE HYDROXAMIC ACID AND ITS USE | |
| FR2904626B1 (fr) | Derives de pyrazolo[4,3]thiazole, leur preparation et leur application en therapeutique | |
| GB2444687A8 (en) | Animal model with induced arrhythmia | |
| RU2005137426A (ru) | ПРИМЕНЕНИЕ 7-БРОМИМИДАЗО[4,5-b]ИНДОЛ-2-ТИОНА ДЛЯ ЗАЩИТЫ ОРГАНИЗМА ОТ ВОЗДЕЙСТВИЯ ГИПОБАРИЧЕСКОЙ, ГЕМИЧЕСКОЙ И ГИПЕРКАПНИЧЕСКОЙ ГИПОКСИИ | |
| ES1060422Y (es) | Almohada terapeutica de cascara de alforfon. | |
| RU2005128615A (ru) | Средство для лечения заболеваний пародонта | |
| ATE372220T1 (de) | Kupplungskörper | |
| FR2885386B1 (fr) | Collecteur d'echappement | |
| ES1063922Y (es) | "maquina formadora de pieza de masa para panaderia y pasteleria perfeccionada" | |
| Buckland | Focus on REACH Regulation | |
| ITVB20050003U1 (it) | Trasduttore "penn" | |
| GB0501502D0 (en) | Device to overcome festination for people with Parkinson's disease | |
| ITBO20050163A1 (it) | Dispositivo per l'allenamento |