JP2008517278A - p27のユビキチン化アッセイ及びその使用方法 - Google Patents

p27のユビキチン化アッセイ及びその使用方法 Download PDF

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JP2008517278A
JP2008517278A JP2007536976A JP2007536976A JP2008517278A JP 2008517278 A JP2008517278 A JP 2008517278A JP 2007536976 A JP2007536976 A JP 2007536976A JP 2007536976 A JP2007536976 A JP 2007536976A JP 2008517278 A JP2008517278 A JP 2008517278A
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ubiquitin
label
compound
ubiquitination
ubiquitinated
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JP2008517278A5 (https=
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シュウ,シェイチャン
コックス,サラ
シェ,ウェイリン
マーキュリオ,フランク,エム.
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シグナル ファーマシューティカルズ,エルエルシー
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2007536976A 2004-10-15 2005-10-17 p27のユビキチン化アッセイ及びその使用方法 Pending JP2008517278A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61909204P 2004-10-15 2004-10-15
PCT/US2005/037171 WO2006044747A2 (en) 2004-10-15 2005-10-17 P27 ubiquitination assay and methods of use

Publications (2)

Publication Number Publication Date
JP2008517278A true JP2008517278A (ja) 2008-05-22
JP2008517278A5 JP2008517278A5 (https=) 2008-12-04

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ID=36203595

Family Applications (1)

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JP2007536976A Pending JP2008517278A (ja) 2004-10-15 2005-10-17 p27のユビキチン化アッセイ及びその使用方法

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US (1) US20060194262A1 (https=)
EP (1) EP1810008A4 (https=)
JP (1) JP2008517278A (https=)
AU (1) AU2005295517A1 (https=)
CA (1) CA2584131A1 (https=)
WO (1) WO2006044747A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014510926A (ja) * 2011-04-07 2014-05-01 ザ スクリップス リサーチ インスティテュート 細胞巨大分子の発現を調節する化合物のハイスループットスクリーニング

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8663928B2 (en) * 2006-11-27 2014-03-04 Cis Bio International Method for the detection of post-translational modifications
MX344555B (es) * 2007-05-08 2016-12-20 Hunter Douglas Ind Switzerland Sistema de color multivariado con aplicacion de textura.
JP2011528908A (ja) * 2008-07-25 2011-12-01 プロジェンラ インク. ユビキチンリガーゼのモジュレーターの特定法
GB201007185D0 (en) * 2010-04-29 2010-06-09 Iti Scotland Ltd Ubiquitination assay
CN103196877B (zh) * 2013-03-08 2015-06-03 刘小龙 基于均相时间分辨荧光的检测重金属含量的方法
CN104155452A (zh) * 2013-05-15 2014-11-19 复旦大学 一种检测细胞内蛋白质降解的方法
GB201415688D0 (en) * 2014-09-04 2014-10-22 Univ Edinburgh Method and Systems
ES2965761T3 (es) * 2016-08-08 2024-04-16 Tech Innovation Momentum Fund Israel Limited Partnership Sistemas bacterianos para el análisis de polipéptidos ubiquitilados
WO2019030759A1 (en) 2017-08-08 2019-02-14 Technology Innovation Momentum Fund (Israel) Limited Partnership CHLORAMPHENICOL-RESISTANT TRUNCATED PROTEIN AND USES THEREOF

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003512008A (ja) * 1998-08-28 2003-04-02 ニューヨーク・ユニバーシティ 治療ターゲットとしての新規ユビキチンリガーゼ
WO2003095971A2 (en) * 2001-11-09 2003-11-20 Proteologics, Inc. Posh nucleic acids, polypeptides and related methods
WO2003100064A1 (en) * 2002-05-29 2003-12-04 Kyowa Hakko Kogyo Co., Ltd. Novel ubiquitin ligase
JP2004531218A (ja) * 2001-01-05 2004-10-14 ニューヨーク・ユニバーシティ 増殖性および分化性疾患の治療に有用な化合物の同定方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE424927T1 (de) * 1993-10-28 2009-03-15 Houston Advanced Res Ct Mikrofabriziertes poröses durchflussgerät zur diskreten bestimmung von bindungsreaktionen
US5463564A (en) * 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
US6747128B2 (en) * 1997-08-20 2004-06-08 Gpc Biotech, Inc. Components of ubiquitin ligase complexes, and uses related thereto
US6413725B1 (en) * 1998-08-07 2002-07-02 California Institute Of Technology Biochemical assay to monitor the ubiquitin ligase activities of cullins
US6740495B1 (en) * 2000-04-03 2004-05-25 Rigel Pharmaceuticals, Inc. Ubiquitin ligase assay

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003512008A (ja) * 1998-08-28 2003-04-02 ニューヨーク・ユニバーシティ 治療ターゲットとしての新規ユビキチンリガーゼ
JP2004531218A (ja) * 2001-01-05 2004-10-14 ニューヨーク・ユニバーシティ 増殖性および分化性疾患の治療に有用な化合物の同定方法
WO2003095971A2 (en) * 2001-11-09 2003-11-20 Proteologics, Inc. Posh nucleic acids, polypeptides and related methods
WO2003100064A1 (en) * 2002-05-29 2003-12-04 Kyowa Hakko Kogyo Co., Ltd. Novel ubiquitin ligase

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014510926A (ja) * 2011-04-07 2014-05-01 ザ スクリップス リサーチ インスティテュート 細胞巨大分子の発現を調節する化合物のハイスループットスクリーニング

Also Published As

Publication number Publication date
EP1810008A4 (en) 2008-09-10
EP1810008A2 (en) 2007-07-25
CA2584131A1 (en) 2006-04-27
WO2006044747A2 (en) 2006-04-27
AU2005295517A1 (en) 2006-04-27
US20060194262A1 (en) 2006-08-31
WO2006044747A3 (en) 2006-10-12

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