JP2008513027A5 - - Google Patents
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- Publication number
- JP2008513027A5 JP2008513027A5 JP2007532656A JP2007532656A JP2008513027A5 JP 2008513027 A5 JP2008513027 A5 JP 2008513027A5 JP 2007532656 A JP2007532656 A JP 2007532656A JP 2007532656 A JP2007532656 A JP 2007532656A JP 2008513027 A5 JP2008513027 A5 JP 2008513027A5
- Authority
- JP
- Japan
- Prior art keywords
- pal
- ammonia lyase
- phenylalanine ammonia
- phenylalanine
- lyase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108700023158 Phenylalanine ammonia-lyases Proteins 0.000 claims 37
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 101100462457 African swine fever virus (strain Badajoz 1971 Vero-adapted) Ba71V-049 gene Proteins 0.000 claims 1
- 241000221523 Rhodotorula toruloides Species 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 238000002703 mutagenesis Methods 0.000 claims 1
- 231100000350 mutagenesis Toxicity 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 238000002708 random mutagenesis Methods 0.000 claims 1
- 102200063469 rs869312823 Human genes 0.000 claims 1
- 102220102437 rs878855252 Human genes 0.000 claims 1
- 238000002741 site-directed mutagenesis Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61077004P | 2004-09-17 | 2004-09-17 | |
| US65195005P | 2005-02-09 | 2005-02-09 | |
| PCT/US2005/033895 WO2006034373A2 (en) | 2004-09-17 | 2005-09-19 | Variants and chemically-modified variants of phenylalanine ammonia-lyase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008513027A JP2008513027A (ja) | 2008-05-01 |
| JP2008513027A5 true JP2008513027A5 (https=) | 2008-11-06 |
Family
ID=36090659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007532656A Pending JP2008513027A (ja) | 2004-09-17 | 2005-09-19 | フェニルアラニンアンモニアーリアーゼの改変体および化学的に修飾された改変体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7553653B2 (https=) |
| EP (1) | EP1814984A2 (https=) |
| JP (1) | JP2008513027A (https=) |
| AU (1) | AU2005286763A1 (https=) |
| CA (1) | CA2580679A1 (https=) |
| WO (1) | WO2006034373A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1708690T3 (pl) | 2003-11-17 | 2017-01-31 | Biomarin Pharmaceutical Inc. | Leczenie fenyloketonurii za pomocą BH4 |
| US7531341B1 (en) | 2006-06-12 | 2009-05-12 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
| US7534595B2 (en) * | 2006-06-12 | 2009-05-19 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
| ES2409756T3 (es) * | 2006-12-04 | 2013-06-27 | Promedior, Inc. | Combinación de SAP y de enalapril para su uso en tratamiento de trastornos fibróticos o fibroproliferativos |
| LT2545939T (lt) | 2007-04-11 | 2021-03-10 | Biomarin Pharmaceutical Inc. | Tetrahidrobiopterinas, skirtas gydyti ligas, susijusias supadidėjusiu fenilalanino kiekiu |
| US9884899B2 (en) | 2007-07-06 | 2018-02-06 | Promedior, Inc. | Methods for treating fibrosis using CRP antagonists |
| US8497243B2 (en) * | 2007-07-06 | 2013-07-30 | Promedior, Inc. | Methods and compositions useful in the treatment of mucositis |
| US7560263B2 (en) * | 2007-08-17 | 2009-07-14 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof |
| WO2010014225A2 (en) * | 2008-07-30 | 2010-02-04 | Biomarin Pharmaceutical Inc. | Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase |
| CA2754961C (en) * | 2009-03-11 | 2018-04-10 | Promedior, Inc. | Treatment and diagnostic methods for hypersensitive disorders |
| EP2405929B1 (en) * | 2009-03-11 | 2018-06-06 | Promedior Inc. | A sap polypeptide for use in the treatment of autoimmune disorders and graft vs host disease |
| UA110323C2 (en) * | 2009-06-04 | 2015-12-25 | Promedior Inc | Derivative of serum amyloid p and their receipt and application |
| EP2987803B1 (en) * | 2009-06-17 | 2018-08-29 | Promedior Inc. | Sap variants and their use |
| ES2690542T3 (es) | 2010-02-04 | 2018-11-21 | Biomarin Pharmaceutical Inc. | Método para purificar variantes de fenilalanina amoníaco-liasa procariotas |
| NZ607996A (en) | 2010-09-22 | 2014-07-25 | Alios Biopharma Inc | Substituted nucleotide analogs |
| CA2860234A1 (en) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
| HK1206362A1 (zh) | 2012-03-21 | 2016-01-08 | Alios Biopharma, Inc. | 硫代氨基磷酸酯核苷酸前藥的固體形式 |
| WO2013142157A1 (en) | 2012-03-22 | 2013-09-26 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| EP2877584A4 (en) * | 2012-07-26 | 2016-03-30 | Casa Luker S A | METHODS FOR INCREASING THE PRODUCTION OF PHENOLIC COMPOUNDS FROM THEBROMA COCOA |
| NZ713396A (en) | 2013-04-18 | 2020-06-26 | Codexis Inc | Engineered phenylalanine ammonia lyase polypeptides |
| WO2015161019A1 (en) | 2014-04-16 | 2015-10-22 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| ES2881384T3 (es) | 2015-05-13 | 2021-11-29 | Synlogic Operating Co Inc | Bacterias manipuladas para reducir la hiperfenilalaninemia |
| CN111655841A (zh) | 2017-06-21 | 2020-09-11 | 同生运营公司 | 用于治疗紊乱的细菌 |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| US10900055B2 (en) | 2018-06-12 | 2021-01-26 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| JP2021531749A (ja) * | 2018-07-12 | 2021-11-25 | コデクシス， インコーポレイテッド | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
| CA3122524A1 (en) | 2018-12-14 | 2020-06-18 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| CN114828863A (zh) * | 2019-10-17 | 2022-07-29 | 医肯纳肿瘤学公司 | 聚乙二醇化犬尿氨酸酶以及其用于治疗癌症的用途 |
| JP2023512683A (ja) | 2020-02-04 | 2023-03-28 | コデクシス， インコーポレイテッド | 操作されたロイシンデカルボキシラーゼ |
| BR112022018571A2 (pt) * | 2020-03-20 | 2022-11-01 | Synlogic Operating Co Inc | Microrganismos manipulados para reduzir a hiperfenilalaninemia |
| CN116897205A (zh) | 2020-08-28 | 2023-10-17 | 科德克希思公司 | 工程化淀粉酶变体 |
| AU2021334371A1 (en) | 2020-08-28 | 2023-03-09 | Codexis, Inc. | Engineered protease variants |
| JP2024540358A (ja) | 2021-11-01 | 2024-10-31 | シンティス バイオ，インコーポレイティド | 工学操作ロイシン脱炭酸酵素 |
| CN118931888A (zh) * | 2023-05-09 | 2024-11-12 | 重庆派金生物科技有限公司 | 苯丙氨酸裂解酶突变体及其偶联物或其药学上可接受的盐 |
| WO2025072636A1 (en) * | 2023-09-28 | 2025-04-03 | Aperiam Bio, Inc. | Degradation of toxin in vivo |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4562151A (en) | 1983-09-06 | 1985-12-31 | Monsanto Company | Stabilization of L-phenylalanine ammonia-lyase enzyme |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| DK75593D0 (https=) * | 1993-06-25 | 1993-06-25 | Novo Nordisk As | |
| US5981239A (en) | 1997-09-24 | 1999-11-09 | Great Lakes Chemical Corp. | Synthesis of optically active phenylalanine analogs using Rhodotorula graminis |
| US6451986B1 (en) | 1998-06-22 | 2002-09-17 | Immunex Corporation | Site specific protein modification |
| US6461849B1 (en) | 1998-10-13 | 2002-10-08 | Novozymes, A/S | Modified polypeptide |
| US6686164B1 (en) | 1998-10-30 | 2004-02-03 | Novozymes A/S | Low allergenic protein variants |
| US6395299B1 (en) | 1999-02-12 | 2002-05-28 | Biostream, Inc. | Matrices for drug delivery and methods for making and using the same |
| US6586398B1 (en) | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
| AU2001257032A1 (en) | 2000-04-14 | 2001-10-30 | University Of South Carolina Research Foundation | Cloning, overexpression and therapeutic uses of bioactive histidine ammonia lyase |
| US6967097B2 (en) * | 2000-07-24 | 2005-11-22 | Pcbu Services, Inc. | Phenylalainine ammonia lyase polypeptide and polynucleotide sequences and methods of obtaining and using same |
| KR20040088538A (ko) * | 2002-02-26 | 2004-10-16 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 유전 인자의 재조합 방법 |
| JP2006516095A (ja) | 2002-11-14 | 2006-06-22 | ザ スクリップス リサーチ インスティテュート | 脂肪酸アミドヒドロラーゼ（ｆａａｈ）の結晶形 |
-
2005
- 2005-09-19 WO PCT/US2005/033895 patent/WO2006034373A2/en not_active Ceased
- 2005-09-19 US US11/230,374 patent/US7553653B2/en not_active Expired - Fee Related
- 2005-09-19 AU AU2005286763A patent/AU2005286763A1/en not_active Abandoned
- 2005-09-19 EP EP05816095A patent/EP1814984A2/en not_active Withdrawn
- 2005-09-19 JP JP2007532656A patent/JP2008513027A/ja active Pending
- 2005-09-19 CA CA002580679A patent/CA2580679A1/en not_active Abandoned
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