JP2008513027A5 - - Google Patents
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- Publication number
- JP2008513027A5 JP2008513027A5 JP2007532656A JP2007532656A JP2008513027A5 JP 2008513027 A5 JP2008513027 A5 JP 2008513027A5 JP 2007532656 A JP2007532656 A JP 2007532656A JP 2007532656 A JP2007532656 A JP 2007532656A JP 2008513027 A5 JP2008513027 A5 JP 2008513027A5
- Authority
- JP
- Japan
- Prior art keywords
- pal
- ammonia lyase
- phenylalanine ammonia
- phenylalanine
- lyase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108700023158 Phenylalanine ammonia-lyases Proteins 0.000 claims 37
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 101100462457 African swine fever virus (strain Badajoz 1971 Vero-adapted) Ba71V-049 gene Proteins 0.000 claims 1
- 241000221523 Rhodotorula toruloides Species 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 238000002703 mutagenesis Methods 0.000 claims 1
- 231100000350 mutagenesis Toxicity 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 238000002708 random mutagenesis Methods 0.000 claims 1
- 102200063469 rs869312823 Human genes 0.000 claims 1
- 102220102437 rs878855252 Human genes 0.000 claims 1
- 238000002741 site-directed mutagenesis Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61077004P | 2004-09-17 | 2004-09-17 | |
| US65195005P | 2005-02-09 | 2005-02-09 | |
| PCT/US2005/033895 WO2006034373A2 (en) | 2004-09-17 | 2005-09-19 | Variants and chemically-modified variants of phenylalanine ammonia-lyase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008513027A JP2008513027A (ja) | 2008-05-01 |
| JP2008513027A5 true JP2008513027A5 (https=) | 2008-11-06 |
Family
ID=36090659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007532656A Pending JP2008513027A (ja) | 2004-09-17 | 2005-09-19 | フェニルアラニンアンモニアーリアーゼの改変体および化学的に修飾された改変体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7553653B2 (https=) |
| EP (1) | EP1814984A2 (https=) |
| JP (1) | JP2008513027A (https=) |
| AU (1) | AU2005286763A1 (https=) |
| CA (1) | CA2580679A1 (https=) |
| WO (1) | WO2006034373A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070005550A (ko) | 2003-11-17 | 2007-01-10 | 바이오마린 파머수티컬 인크. | 대사 장애 치료를 위한 조성물 및 방법 |
| US7534595B2 (en) * | 2006-06-12 | 2009-05-19 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
| US7531341B1 (en) | 2006-06-12 | 2009-05-12 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
| CA2708004C (en) * | 2006-12-04 | 2015-12-01 | Promedior, Inc. | Conjoint therapy for treating fibrotic diseases |
| WO2008128049A2 (en) | 2007-04-11 | 2008-10-23 | Biomarin Pharmaceutical Inc. | Methods of administering tetrahydrobiopterin, associated compositions, and methods of measuring |
| US9884899B2 (en) | 2007-07-06 | 2018-02-06 | Promedior, Inc. | Methods for treating fibrosis using CRP antagonists |
| US8497243B2 (en) * | 2007-07-06 | 2013-07-30 | Promedior, Inc. | Methods and compositions useful in the treatment of mucositis |
| US7537923B2 (en) * | 2007-08-17 | 2009-05-26 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof |
| WO2010014225A2 (en) | 2008-07-30 | 2010-02-04 | Biomarin Pharmaceutical Inc. | Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase |
| PT2405928T (pt) * | 2009-03-11 | 2017-02-07 | Promedior Inc | Métodos de tratamento e de diagnóstico para patologias de hipersensibilidade |
| CA2755047C (en) * | 2009-03-11 | 2018-12-04 | Promedior, Inc. | Treatment methods for autoimmune disorders |
| UA110323C2 (en) * | 2009-06-04 | 2015-12-25 | Promedior Inc | Derivative of serum amyloid p and their receipt and application |
| EP2987803B1 (en) | 2009-06-17 | 2018-08-29 | Promedior Inc. | Sap variants and their use |
| ES2582459T3 (es) | 2010-02-04 | 2016-09-13 | Biomarin Pharmaceutical Inc. | Composiciones de variantes de fenilalanina amoníaco-liasa de procariotas y métodos de uso de sus composiciones |
| BR112013005872A2 (pt) | 2010-09-22 | 2019-09-24 | Alios Biopharma Inc | compostos, composição farmacêutica e respectivos usos |
| EP2794630A4 (en) | 2011-12-22 | 2015-04-01 | Alios Biopharma Inc | SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE |
| WO2013142124A1 (en) | 2012-03-21 | 2013-09-26 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| US9012427B2 (en) | 2012-03-22 | 2015-04-21 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| WO2014018822A2 (en) * | 2012-07-26 | 2014-01-30 | Casa Luker S.A. | Methods for increasing the production of phenolic compounds from theobroma cacao |
| KR102218930B1 (ko) | 2013-04-18 | 2021-02-23 | 코덱시스, 인코포레이티드 | 조작된 페닐알라닌 암모니아 리아제 폴리펩티드 |
| WO2015161019A1 (en) | 2014-04-16 | 2015-10-22 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| US10610546B2 (en) | 2015-05-13 | 2020-04-07 | Synlogic Operating Company Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| CN111655841A (zh) | 2017-06-21 | 2020-09-11 | 同生运营公司 | 用于治疗紊乱的细菌 |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| US10900055B2 (en) | 2018-06-12 | 2021-01-26 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| JP2021531749A (ja) * | 2018-07-12 | 2021-11-25 | コデクシス， インコーポレイテッド | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
| SG11202105668PA (en) | 2018-12-14 | 2021-06-29 | Codexis Inc | Engineered tyrosine ammonia lyase |
| CA3154817A1 (en) * | 2019-10-17 | 2021-04-22 | James Nolan | Pegylated kynureninase enzymes and uses thereof for the treatment of cancer |
| WO2021158686A1 (en) | 2020-02-04 | 2021-08-12 | Codexis, Inc. | Engineered leucine decarboxylases |
| CN115298308A (zh) * | 2020-03-20 | 2022-11-04 | 同生运营公司 | 经工程化以减轻高苯丙氨酸血症的微生物 |
| EP4204554A4 (en) | 2020-08-28 | 2024-08-21 | Codexis, Inc. | MODIFIED PROTEASE VARIANTS |
| MX2023002421A (es) | 2020-08-28 | 2023-05-18 | Codexis Inc | Variantes de amilasa modificadas geneticamente. |
| CN118475692A (zh) | 2021-11-01 | 2024-08-09 | 森蒂斯生物公司 | 工程化亮氨酸脱羧酶 |
| CN118931888A (zh) * | 2023-05-09 | 2024-11-12 | 重庆派金生物科技有限公司 | 苯丙氨酸裂解酶突变体及其偶联物或其药学上可接受的盐 |
| US20250108095A1 (en) * | 2023-09-28 | 2025-04-03 | Aperiam Bio, Inc. | Degradation of toxins in vivo |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4562151A (en) | 1983-09-06 | 1985-12-31 | Monsanto Company | Stabilization of L-phenylalanine ammonia-lyase enzyme |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| DK75593D0 (https=) * | 1993-06-25 | 1993-06-25 | Novo Nordisk As | |
| US5981239A (en) | 1997-09-24 | 1999-11-09 | Great Lakes Chemical Corp. | Synthesis of optically active phenylalanine analogs using Rhodotorula graminis |
| US6451986B1 (en) | 1998-06-22 | 2002-09-17 | Immunex Corporation | Site specific protein modification |
| US6461849B1 (en) | 1998-10-13 | 2002-10-08 | Novozymes, A/S | Modified polypeptide |
| US6686164B1 (en) | 1998-10-30 | 2004-02-03 | Novozymes A/S | Low allergenic protein variants |
| IL138990A0 (en) | 1999-02-12 | 2001-11-25 | Biostream Inc | Matrices for drug delivery and methods for making and using the same |
| US6586398B1 (en) | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
| AU2001257032A1 (en) | 2000-04-14 | 2001-10-30 | University Of South Carolina Research Foundation | Cloning, overexpression and therapeutic uses of bioactive histidine ammonia lyase |
| US6967097B2 (en) * | 2000-07-24 | 2005-11-22 | Pcbu Services, Inc. | Phenylalainine ammonia lyase polypeptide and polynucleotide sequences and methods of obtaining and using same |
| EP1476563B1 (en) * | 2002-02-26 | 2008-09-17 | E.I. Du Pont De Nemours And Company | Method for the recombination of genetic elements |
| US20080124275A1 (en) * | 2002-11-14 | 2008-05-29 | The Scripps Research Institute | Crystalline Form of Fatty Acid Amide Hydrolase (Faah) |
-
2005
- 2005-09-19 US US11/230,374 patent/US7553653B2/en not_active Expired - Fee Related
- 2005-09-19 EP EP05816095A patent/EP1814984A2/en not_active Withdrawn
- 2005-09-19 WO PCT/US2005/033895 patent/WO2006034373A2/en not_active Ceased
- 2005-09-19 CA CA002580679A patent/CA2580679A1/en not_active Abandoned
- 2005-09-19 JP JP2007532656A patent/JP2008513027A/ja active Pending
- 2005-09-19 AU AU2005286763A patent/AU2005286763A1/en not_active Abandoned
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