JP2008512470A

JP2008512470A - アミジン置換アリールアニリン化合物

アミジン置換アリールアニリン化合物 Download PDF

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Publication number: JP2008512470A
Authority: JP; Japan
Prior art keywords: compound; formula; hydroxy; compounds; hydrogen
Prior art date: 2004-09-10
Legal status : Withdrawn

Application number

JP2007531297A

Other languages

English (en)

Japanese (ja)

Other versions

JP2008512470A5 (enExample

Inventor

マーティンエス．リンゼル，

ジョンアール．ジェーコブセン，

ニンニンスー，

Original Assignee

セラヴァンス，インコーポレーテッド

Priority date

2004-09-10

Filing date

2005-09-08

Publication date

2008-04-24

2005-09-08 Application filed by セラヴァンス，インコーポレーテッド filed Critical セラヴァンス，インコーポレーテッド

2008-04-24 Publication of JP2008512470A publication Critical patent/JP2008512470A/ja

2008-10-30 Publication of JP2008512470A5 publication Critical patent/JP2008512470A5/ja

Status Withdrawn legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 201
238000000034 method Methods 0.000 claims abstract description 56
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239000008194 pharmaceutical composition Substances 0.000 claims abstract description 31
230000000694 effects Effects 0.000 claims abstract description 25
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 23
201000010099 disease Diseases 0.000 claims abstract description 22
239000000048 adrenergic agonist Substances 0.000 claims abstract description 15
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230000008569 process Effects 0.000 claims abstract description 3
-1 —NR e R f Chemical group 0.000 claims description 74
239000000203 mixture Substances 0.000 claims description 59
150000003839 salts Chemical class 0.000 claims description 52
239000001257 hydrogen Substances 0.000 claims description 40
229910052739 hydrogen Inorganic materials 0.000 claims description 40
238000009472 formulation Methods 0.000 claims description 38
239000003814 drug Substances 0.000 claims description 35
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 31
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 29
125000000217 alkyl group Chemical group 0.000 claims description 28
239000012453 solvate Substances 0.000 claims description 23
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239000002253 acid Substances 0.000 claims description 16
229910052757 nitrogen Inorganic materials 0.000 claims description 16
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IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
125000003277 amino group Chemical group 0.000 claims description 12
239000003246 corticosteroid Substances 0.000 claims description 11
150000002431 hydrogen Chemical class 0.000 claims description 11
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