JP2008509999A - 選択的なエストロゲン受容体モジュレーターとしてのベンズオキサゼピン誘導体 - Google Patents
選択的なエストロゲン受容体モジュレーターとしてのベンズオキサゼピン誘導体 Download PDFInfo
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- JP2008509999A JP2008509999A JP2007527837A JP2007527837A JP2008509999A JP 2008509999 A JP2008509999 A JP 2008509999A JP 2007527837 A JP2007527837 A JP 2007527837A JP 2007527837 A JP2007527837 A JP 2007527837A JP 2008509999 A JP2008509999 A JP 2008509999A
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- YURKVGHCTXQSSU-UHFFFAOYSA-N tert-butyl-[4-[8-[tert-butyl(dimethyl)silyl]oxy-5-[[3-(2-chloroethoxy)phenyl]methyl]-3,4-dihydro-2h-1,5-benzoxazepin-3-yl]phenoxy]-dimethylsilane Chemical compound C1=CC(O[Si](C)(C)C(C)(C)C)=CC=C1C1CN(CC=2C=C(OCCCl)C=CC=2)C2=CC=C(O[Si](C)(C)C(C)(C)C)C=C2OC1 YURKVGHCTXQSSU-UHFFFAOYSA-N 0.000 description 1
- MXVHPWGLSGSZRG-UHFFFAOYSA-N tert-butyl-[4-[8-[tert-butyl(dimethyl)silyl]oxy-5-[[4-(2-chloroethoxy)phenyl]methyl]-3,4-dihydro-2h-1,5-benzoxazepin-3-yl]phenoxy]-dimethylsilane Chemical compound C1=CC(O[Si](C)(C)C(C)(C)C)=CC=C1C1CN(CC=2C=CC(OCCCl)=CC=2)C2=CC=C(O[Si](C)(C)C(C)(C)C)C=C2OC1 MXVHPWGLSGSZRG-UHFFFAOYSA-N 0.000 description 1
- SNPLUAOADKXHPY-UHFFFAOYSA-N tert-butyl-[[3-[3-[tert-butyl(dimethyl)silyl]oxyphenyl]-2,3,4,5-tetrahydro-1,5-benzoxazepin-8-yl]oxy]-dimethylsilane Chemical compound CC(C)(C)[Si](C)(C)OC1=CC=CC(C2COC3=CC(O[Si](C)(C)C(C)(C)C)=CC=C3NC2)=C1 SNPLUAOADKXHPY-UHFFFAOYSA-N 0.000 description 1
- RHQMFMXRCZPEIV-UHFFFAOYSA-N tert-butyl-[[3-[3-[tert-butyl(dimethyl)silyl]oxyphenyl]-5-[[4-(2-piperidin-1-ylethoxy)phenyl]methyl]-3,4-dihydro-2h-1,5-benzoxazepin-8-yl]oxy]-dimethylsilane Chemical compound CC(C)(C)[Si](C)(C)OC1=CC=CC(C2CN(CC=3C=CC(OCCN4CCCCC4)=CC=3)C3=CC=C(O[Si](C)(C)C(C)(C)C)C=C3OC2)=C1 RHQMFMXRCZPEIV-UHFFFAOYSA-N 0.000 description 1
- WEXFXSDIUYMQEK-UHFFFAOYSA-N tert-butyl-[[3-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-2,3,4,5-tetrahydro-1,5-benzoxazepin-8-yl]oxy]-dimethylsilane Chemical compound C1=CC(O[Si](C)(C)C(C)(C)C)=CC=C1C1COC2=CC(O[Si](C)(C)C(C)(C)C)=CC=C2NC1 WEXFXSDIUYMQEK-UHFFFAOYSA-N 0.000 description 1
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 125000005455 trithianyl group Chemical group 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 231100001042 uterine atrophy Toxicity 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 230000000283 vasomotion Effects 0.000 description 1
- 208000004043 venous thromboembolism Diseases 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pregnancy & Childbirth (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60205404P | 2004-08-17 | 2004-08-17 | |
| PCT/US2005/026944 WO2006023242A1 (en) | 2004-08-17 | 2005-07-28 | Benzoxazepine derivatives as selective estrogen receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008509999A true JP2008509999A (ja) | 2008-04-03 |
| JP2008509999A5 JP2008509999A5 (cg-RX-API-DMAC7.html) | 2008-09-04 |
Family
ID=35431802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007527837A Withdrawn JP2008509999A (ja) | 2004-08-17 | 2005-07-28 | 選択的なエストロゲン受容体モジュレーターとしてのベンズオキサゼピン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060040917A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1778656A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2008509999A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101039925A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2576747A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006023242A1 (cg-RX-API-DMAC7.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013537213A (ja) * | 2010-09-20 | 2013-09-30 | ノバルティス アーゲー | クラジノース環のＣ−４”をエポキシド基で修飾した９−デオキソ−９ａ−アザ−９ａ−ホモエリスロマイシンＡの新規製造方法 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101363472B1 (ko) | 2011-03-30 | 2014-02-17 | 한국화학연구원 | 신규한 크로멘 유도체, 이의 약학적으로 허용가능한 염 또는 이의 이성질체, 이의 제조방법 및 이를 포함하는 ｐａｒ-1 관련 질환의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5552412A (en) * | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| DE19833786A1 (de) * | 1998-07-18 | 2000-01-20 | Schering Ag | Benzocycloheptene, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
| WO2002094788A1 (en) * | 2001-05-22 | 2002-11-28 | Eli Lilly And Company | 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods |
-
2005
- 2005-07-28 CN CNA2005800351717A patent/CN101039925A/zh active Pending
- 2005-07-28 US US11/191,499 patent/US20060040917A1/en not_active Abandoned
- 2005-07-28 JP JP2007527837A patent/JP2008509999A/ja not_active Withdrawn
- 2005-07-28 EP EP05767648A patent/EP1778656A1/en not_active Withdrawn
- 2005-07-28 WO PCT/US2005/026944 patent/WO2006023242A1/en not_active Ceased
- 2005-07-28 CA CA002576747A patent/CA2576747A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013537213A (ja) * | 2010-09-20 | 2013-09-30 | ノバルティス アーゲー | クラジノース環のＣ−４”をエポキシド基で修飾した９−デオキソ−９ａ−アザ−９ａ−ホモエリスロマイシンＡの新規製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101039925A (zh) | 2007-09-19 |
| EP1778656A1 (en) | 2007-05-02 |
| WO2006023242A1 (en) | 2006-03-02 |
| US20060040917A1 (en) | 2006-02-23 |
| CA2576747A1 (en) | 2006-03-02 |
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