JP2008508271A - ビアリール複素環式化合物ならびにその化合物を製造および使用する方法 - Google Patents
ビアリール複素環式化合物ならびにその化合物を製造および使用する方法 Download PDFInfo
- Publication number
- JP2008508271A JP2008508271A JP2007523532A JP2007523532A JP2008508271A JP 2008508271 A JP2008508271 A JP 2008508271A JP 2007523532 A JP2007523532 A JP 2007523532A JP 2007523532 A JP2007523532 A JP 2007523532A JP 2008508271 A JP2008508271 A JP 2008508271A
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- Prior art keywords
- alkyl
- group
- compound
- pharmaceutically acceptable
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(NC[C@@](CN1B(*)*(*)N)OC1=O)=O Chemical compound CC(NC[C@@](CN1B(*)*(*)N)OC1=O)=O 0.000 description 8
- BFTHYMXYWKRDSX-UHFFFAOYSA-N C=CCC(C#N)Br Chemical compound C=CCC(C#N)Br BFTHYMXYWKRDSX-UHFFFAOYSA-N 0.000 description 1
- RHIRRXGPXGFAJH-UHFFFAOYSA-O CC(C)(C(C)(C)OBc(c(F)c1)ccc1N(CC(CNC(C)=O)O1)C1=O)[OH2+] Chemical compound CC(C)(C(C)(C)OBc(c(F)c1)ccc1N(CC(CNC(C)=O)O1)C1=O)[OH2+] RHIRRXGPXGFAJH-UHFFFAOYSA-O 0.000 description 1
- MDNMTNMZQABZBQ-UHFFFAOYSA-N CC(NCC(CN1c(cc2)ccc2-c(cc2)ccc2C#N)OC1=O)=O Chemical compound CC(NCC(CN1c(cc2)ccc2-c(cc2)ccc2C#N)OC1=O)=O MDNMTNMZQABZBQ-UHFFFAOYSA-N 0.000 description 1
- IUPMBNHROWEVSK-LBPRGKRZSA-N CC(NC[C@@H](CN1c2cc(F)c(-c(cc3)cnc3[IH]N)c(F)c2)OC1=O)=O Chemical compound CC(NC[C@@H](CN1c2cc(F)c(-c(cc3)cnc3[IH]N)c(F)c2)OC1=O)=O IUPMBNHROWEVSK-LBPRGKRZSA-N 0.000 description 1
- HMPHQMPMGVYNDL-ZDUSSCGKSA-N CC(NC[C@@H](CN1c2ccc(-c(cc3)cnc3[IH]N)c(F)c2)OC1=O)=O Chemical compound CC(NC[C@@H](CN1c2ccc(-c(cc3)cnc3[IH]N)c(F)c2)OC1=O)=O HMPHQMPMGVYNDL-ZDUSSCGKSA-N 0.000 description 1
- HNJZPSOMNPJXSJ-INIZCTEOSA-N CC(NC[C@@H](CN1c2ccc(-c3ccnc(CC#N)c3)c(F)c2)OC1=O)=O Chemical compound CC(NC[C@@H](CN1c2ccc(-c3ccnc(CC#N)c3)c(F)c2)OC1=O)=O HNJZPSOMNPJXSJ-INIZCTEOSA-N 0.000 description 1
- JWAWEQBUZOGIBZ-UHFFFAOYSA-N C[n]1nncc1 Chemical compound C[n]1nncc1 JWAWEQBUZOGIBZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59177104P | 2004-07-28 | 2004-07-28 | |
PCT/US2004/039966 WO2006022794A1 (fr) | 2004-07-28 | 2004-12-01 | Composes hétérocycliques de biaryle et procédés de fabrication et d’utilisation desdits composés |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2008508271A true JP2008508271A (ja) | 2008-03-21 |
Family
ID=34960158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007523532A Pending JP2008508271A (ja) | 2004-07-28 | 2004-12-01 | ビアリール複素環式化合物ならびにその化合物を製造および使用する方法 |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1778653A1 (fr) |
JP (1) | JP2008508271A (fr) |
WO (1) | WO2006022794A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100948345B1 (ko) * | 2006-12-08 | 2010-03-22 | 주식회사 레고켐 바이오사이언스 | 신규한 옥사졸리디논 유도체, 이의 제조방법 및 이를함유하는 의약 조성물 |
US7666864B2 (en) | 2008-03-26 | 2010-02-23 | Global Alliance For Tb Drug Development | Bicyclic nitroimidazole-substituted phenyl oxazolidinones |
UY36402A (es) | 2014-11-14 | 2016-06-30 | Melinta Therapeutics Inc | Método para tratar, prevenir, o reducir el riesgo de infección cutánea |
CN104592163B (zh) * | 2015-01-08 | 2016-08-24 | 爱斯特(成都)生物制药有限公司 | 一种手性2-苯基吡咯烷的合成方法 |
WO2017066964A1 (fr) * | 2015-10-22 | 2017-04-27 | Merck Sharp & Dohme Corp. | Composés oxazolidinone et procédés d'utilisation de ces derniers en tant qu'agents antibactériens |
US10995097B2 (en) * | 2016-03-11 | 2021-05-04 | The Board Of Trustees Of The University Of Illinois | Small molecules active against gram-negative bacteria |
WO2018237140A1 (fr) | 2017-06-23 | 2018-12-27 | The Board Of Trustees Of The University Of Illinois | Inhibiteurs de la topoisomérase ayant une activité antibactérienne et une activité anti-cancéreuse |
WO2020147504A1 (fr) * | 2019-01-18 | 2020-07-23 | Merck Sharp & Dohme Corp. | Composés d'oxazolidinone et leurs procédés d'utilisation comme agents antibactériens |
WO2021184339A1 (fr) | 2020-03-20 | 2021-09-23 | Merck Sharp & Dohme Corp. | Composé d'oxazolidinone et procédés d'utilisation de celui-ci comme agent antibactérien |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2458547A2 (fr) * | 1978-06-09 | 1981-01-02 | Delalande Sa | Nouvelles n-aryle azolones, leur procede de preparation et leur application en therapeutique |
EP0352781A2 (fr) * | 1988-07-29 | 1990-01-31 | The Du Pont Merck Pharmaceutical Company | Dérivés d'aminométhyloxooxazolidinyl-arylbenzène comme agents antibactériens |
WO1993009103A1 (fr) * | 1991-11-01 | 1993-05-13 | The Upjohn Company | Aryl- et heteroarylphenyloxazolidinones substituees, utilisees comme agents antibacteriens |
US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
WO2001094342A1 (fr) * | 2000-06-05 | 2001-12-13 | Dong A Pharm. Co., Ltd. | Nouveaux derives oxazolidinone et processus de preparation de ces derives |
WO2004029066A2 (fr) * | 2002-09-26 | 2004-04-08 | Rib-X Pharmaceuticals, Inc. | Composes heterocycliques bifonctionnels et procedes de fabrication et d'utilisation de ces composes |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004267007C1 (en) * | 2003-06-03 | 2010-04-29 | Melinta Subsidiary Corp. | Biaryl heterocyclic compounds and methods of making and using the same |
-
2004
- 2004-12-01 JP JP2007523532A patent/JP2008508271A/ja active Pending
- 2004-12-01 EP EP04812487A patent/EP1778653A1/fr not_active Withdrawn
- 2004-12-01 WO PCT/US2004/039966 patent/WO2006022794A1/fr active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2458547A2 (fr) * | 1978-06-09 | 1981-01-02 | Delalande Sa | Nouvelles n-aryle azolones, leur procede de preparation et leur application en therapeutique |
EP0352781A2 (fr) * | 1988-07-29 | 1990-01-31 | The Du Pont Merck Pharmaceutical Company | Dérivés d'aminométhyloxooxazolidinyl-arylbenzène comme agents antibactériens |
US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
WO1993009103A1 (fr) * | 1991-11-01 | 1993-05-13 | The Upjohn Company | Aryl- et heteroarylphenyloxazolidinones substituees, utilisees comme agents antibacteriens |
WO2001094342A1 (fr) * | 2000-06-05 | 2001-12-13 | Dong A Pharm. Co., Ltd. | Nouveaux derives oxazolidinone et processus de preparation de ces derives |
WO2004029066A2 (fr) * | 2002-09-26 | 2004-04-08 | Rib-X Pharmaceuticals, Inc. | Composes heterocycliques bifonctionnels et procedes de fabrication et d'utilisation de ces composes |
Also Published As
Publication number | Publication date |
---|---|
EP1778653A1 (fr) | 2007-05-02 |
WO2006022794A1 (fr) | 2006-03-02 |
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Legal Events
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A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110222 |
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A02 | Decision of refusal |
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