JP2008507523A - Skin care composition containing flavonoids and vitamin B3 - Google Patents

Abstract

  A skin care composition is disclosed, the composition comprising (1) about 0.001% to about 10% flavonoid compound, (2) 0.01% to about 15% vitamin B3 compound, and (3) composition. A dermatologically acceptable oil-in-water carrier comprising an oil component of at least about 2% by weight of the total product, the composition being substantially free of titanium dioxide.

Description

  The present invention relates to a skin care composition that provides various improved skin care benefits such as whitening and anti-aging. The invention particularly relates to a composition in oil-in-water form.

  Excessive pigmentation of the skin (aged spots, freckles, spots, darkening, yellowing, uneven color, and the like), wrinkles, and typically associated with skin aging or environmental damage to human skin Various treatments for the skin have been proposed to delay, minimize, or even eliminate other chronic changes. Such treatments range from the application of special cosmetics such as packs and masks and oral intake of vitamins to chemical peeling, laser surgery, photofacial treatments, and other treatments. In general, effective treatment is considered to require greater time, physical and economic investment. There is a strong need for safe and affordable treatments that are effective but can be used daily by consumers.

  Various whitening agents and anti-aging agents are known in the art. It is also known that combinations of active ingredients may provide synergistic benefits. Flavonoids such as hesperidin are known in the art for use on the skin, for example, in Japanese Patent Publication Nos. A11-346792, A2002-255827, A2003-137734, and US Patent Application Publication 2002/13481.

  In order to provide a skin care composition that is safe and effective for the general consumer, a combination of active agents that can be used in various phase types is desired. The oil-in-water phase type is commonly used to provide a composition suitable for daily use. For example, oil-in-water phase type compositions are utilized in emulsions, moisturizing lotions, and specialty care products.

  Recently, skin care compositions that utilize immediate benefit agents to whiten the skin or improve skin tone, such as titanium dioxide, are becoming increasingly popular. Although these immediate benefit agents may provide temporary satisfaction to the consumer, some consumers may cause irritation and other negative skin conditions.

  Based on the above, there is a need for oil-in-water skin care compositions that provide safe and effective skin care treatment benefits over a wide range of formulations and reduce inflammation over a wide range of people. Specifically, there is a need for a composition that provides a whitening effect and / or an anti-aging effect.

  None of the existing technology provides all of the advantages and benefits of the present invention.

The present invention
(1) about 0.001% to about 10% of a flavonoid compound,
(2) about 0.01% to about 15% vitamin B3 compound, and (3) a dermatologically acceptable oil-in-water carrier comprising at least about 2% by weight of the oil component of the total composition,
The composition relates to a skin care composition substantially free of titanium dioxide.

  The present invention also relates to a method for providing a whitening effect comprising the step of applying the aforementioned composition to the skin.

  The present invention also relates to a method for providing an anti-aging effect to the skin comprising the step of applying the aforementioned composition to the skin.

  These and other features, aspects and advantages of the present invention will become apparent to those of ordinary skill in the art upon reading this disclosure in conjunction with the appended claims.

  DETAILED DESCRIPTION While the specification concludes with claims that particularly point out and distinctly claim the invention, it is believed the present invention will be better understood from the following description.

  All percentages, parts and ratios are based on the total weight of the composition of the present invention unless otherwise specified. All such weights for the presented ingredients are based on the concentration of the active substance and thus do not include carriers or by-products that may be included in commercial materials.

  All ingredients such as active substances and other ingredients useful herein may be classified or described according to cosmetic and / or therapeutic benefits, or modes of action deemed to be obvious. . However, it should be understood that the active substances and other ingredients useful herein may in some cases provide multiple cosmetic and / or therapeutic benefits, or may act in multiple modes of action. It is. As such, the classifications herein are for convenience and are not intended to limit the components to a particular application or listed application.

Flavonoid compounds The composition comprises from about 0.001% to about 10%, preferably from about 0.01% to about 5%, more preferably from about 0.05% to about 1% of a flavonoid compound. Flavonoid compounds are known to provide antioxidant, UV absorption, and radical scavenging effects. Flavonoid compounds are also known to be effective in strengthening collagen structure.

  The flavonoid compounds useful herein are derived from either 2-phenylbenzopyrone (I) or 3-phenylbenzopyrone (II) backbone structures as follows: (McGraw-Hill encyclopedia of Science and technology)

  Flavonoid compounds can be further classified into different groups depending on the degree of oxidation or substitution pattern of their heterocycle (ring C). The flavonoid compounds useful herein include unsubstituted flavanone, substituted flavanone, unsubstituted flavone, substituted flavone, unsubstituted chalcone, substituted chalcone, unsubstituted isoflavone, and substituted isoflavone. As used herein, the term “substituted” refers to hydroxyl groups, C1-C8 alkyls, C1-C4 alkoxyls, O-glycosides, and the like, in which one or more hydrogen atoms of a skeletal structure as described above are independently By flavonoid compound replaced with a mixture of substituents. Particularly useful flavonoid compounds herein are selected from the group consisting of substituted flavanones, substituted flavones, substituted chalcones, substituted isoflavones, and mixtures thereof.

  Flavonoid compounds can be obtained as extracts from natural sources such as plants. Examples of suitable flavonoid compounds include flavanone (unsubstituted), flavanonol (3′-hydroxyflavanone), pinocembrin (5,7-dihydroxyflavanone), pinostrobin (5-hydroxyl-7-methoxyflavanone), liquiritigenin (7, 4'-dihydroxyflavanone), liquiritin (4'-glucoside-7,4'-dihydroxyflavanone), butyne (7,3 ', 4'-trihydroxyflavanone), sakuranetin (5,4'-dihydroxy-7-methoxy) Flavanone), sakuranin (5-glucoside-5,4′-dihydroxy-7-methoxyflavanone), isosakuranetin (5,7-dihydroxy-4′-methoxyflavanone), poncillin (7-rhamnoglucoside-5,7-dihydroxy) -4'-Met Siflavanone), naringenin (5,7,4′-trihydroxyflavanone), naringin (7-rhamnoglucoside-5,7,4′-trihydroxyflavanone), hesperitin (5,7,3′-trihydroxy-4) '-Methoxyflavanone), hesperidin (7-rhamnoglucoside-5,7,3'-trihydroxy-4'-methoxyflavanone), flavone (unsubstituted), chrysin (5,7-hydroxyflavone), toringin ) (5-glucoside-5,7-hydroxyflavone), apigenin (5,7,4′-trihydroxyflavone), apiin (7-apio-glucoside-5,7,4′-trihydroxyflavone), cosmosin ( cosmosiin) (7-glucoside-5,7,4'-trihydroxyflavone), acacetin (5,7 , -Dihydroxy-4'-methoxyflavone), fortunellin (7-rhamnoglucoside-5,7, -dihydroxy-4'-methoxyflavone), baicalein (5,6,7-trihydroxyflavone), baicalin (7-glucuronide-5,6,7-trihydroxyflavone), scutellarin (7-glucuronide-5,6,7,4′-tetrahydroxyflavone), diosmethine (5,7,3′-trihydroxy) -4'-methoxyflavone), diosmin (7-rhamnoglucoside-5,7,3'-trihydroxy-4'-methoxyflavone), galandine (3,5,7-trihydroxyflavone), quercetin (3 5,7,3 ′, 4′-pentahydroxyflavone), quercitrin (3-rhamnoside-3,5,7) , 3 ′, 4′-pentahydroxyflavone), rutin (3-rhamnoglucoside-3,5,7,3 ′, 4′-pentahydroxyflavone), rhamnetin (3,5,3 ′, 4′-tetra) Hydroxy-7-methoxyflavone), xanthramnin (3-rhamnoside-3,5,3 ′, 4′-tetrahydroxy-7-methoxyflavone), myricetin (5,7,3 ′, 4 ′, 5′-) Pentahydroxyflavonol), myricitrin (3-rhamnoside-5,7,3 ′, 4 ′, 5′-pentahydroxyflavonol), biflavones such as fukugetin, ginkgetin and bilobetine, isoflavones, chalcones, any of the above substituted flavones Examples include, but are not limited to, isomers and mixtures thereof.

  The flavonoid compounds useful herein can be synthetic materials derived from or modified from natural source materials. By using these chemical modifications, flavonoid compounds can be made more applicable to skin care compositions that have improved solubility or compatibility with other composition components. Preferred modified flavonoid compounds are glycosylated, alkylated, or acylated from natural source materials.

  A particularly useful group of glycoside flavonoids herein is one selected from the general structural formula (III)

式中、Ｒ¹〜Ｒ⁶はＨ、ＯＨ、アルコキシ、及びヒドロキシアルコキシから成る群から独立して、選択され、ここで、そのアルコキシ又はヒドロキシアルコキシ基は分岐状又は非分岐状であり、さらに１〜１８個の炭素原子を有し、さらに式中、Ｚ¹はモノ−、及びオリゴグリコシドラジカルから成る群から選択される。Ｚ¹は、好ましくはヘキソシルラジカル、より好ましくはラムノシルラジカル、及びグルコシルラジカルから成る群から選択される。他のヘキソシルラジカル、例えば、アロシル（allosyl）、アルトロシル（altrosyl）、ガラクトシル、グロシル（gulosyl）、イドシル（idosyl）、マンノシル、及びタロシル（alosyl）を使用することもまた有利である。ペントシルラジカルを使用することもまた、本発明によると有利である場合がある。

Wherein R ^{1 to} R ⁶ are independently selected from the group consisting of H, OH, alkoxy, and hydroxyalkoxy, wherein the alkoxy or hydroxyalkoxy group is branched or unbranched, and further 1 Having ˜18 carbon atoms, wherein Z ¹ is selected from the group consisting of mono- and oligoglycoside radicals. Z ¹ is preferably selected from the group consisting of hexosyl radicals, more preferably rhamnosyl radicals, and glucosyl radicals. It is also advantageous to use other hexosyl radicals such as allosyl, altrosyl, galactosyl, gulosyl, idosyl, mannosyl, and alosyl. It may also be advantageous according to the invention to use pentosyl radicals.

  Another particularly useful group of glycoside flavonoids herein is selected from the general structural formula (IV):

式中Ｒ¹¹〜Ｒ¹⁷はＨ、ＯＨ、アルコキシ、及びヒドロキシアルコキシから成る群から独立して、選択され、ここで、そのアルコキシ又はヒドロキシアルコキシ基は分岐状又は非分岐状であり、さらに１〜１８個の炭素原子を有し、さらに式中、Ｚ²はモノ−及びオリゴグリコシドラジカルから成る群から選択される。Ｚ²は、好ましくはヘキソシルラジカル、より好ましくはラムノシルラジカル、及びグルコシルラジカルから成る群から選択される。他のヘキソシルラジカル、例えば、アロシル（allosyl）、アルトロシル（altrosyl）、ガラクトシル、グロシル（gulosyl）、イドシル（idosyl）、マンノシル、及びタロシル（alosyl）を使用することもまた有利である。ペントシルラジカルを使用することもまた、本発明によると有利である場合がある。

Wherein R ^{11 to} R ¹⁷ are independently selected from the group consisting of H, OH, alkoxy, and hydroxyalkoxy, wherein the alkoxy or hydroxyalkoxy group is branched or unbranched, Having 18 carbon atoms, further wherein Z ² is selected from the group consisting of mono- and oligoglycoside radicals. Z ² is preferably selected from the group consisting of hexosyl radicals, more preferably rhamnosyl radicals, and glucosyl radicals. It is also advantageous to use other hexosyl radicals such as allosyl, altrosyl, galactosyl, gulosyl, idosyl, mannosyl, and alosyl. It may also be advantageous according to the invention to use pentosyl radicals.

  In one particularly preferred embodiment of the present invention, the glycoside flavonoid is selected from the group consisting of glucosyl hesperidin, glucosyl rutin, glucosyl myristitrin, glucosyl isoquercitrin, glucosilk ercitrin, methyl hesperidin, and mixtures thereof. These glucoside flavonoid compounds can be obtained from related natural flavonoid compounds by biochemical methods. The glucosyl group (s) can be linked to one or more hydroxides of the original material.

A typical formula for glucosyl rutin is:

A typical formula for glucosyl hesperidin is:

  The alkylated flavonoid compounds useful herein are alkoxy or hydroxyalkoxy flavonoids that are usually derived by chemical modification of common natural flavonoids. Examples of alkylated flavonoid compounds useful herein are as follows: These formulas are merely representative, and it is possible for an alkyl or hydroxyalkyl group to be linked to other existing hydroxyl groups.

A typical formula for troxertin (3 ', 4', 7-tri-hydroxyethoxy rutile) is:

A typical formula for monoxertine (7-hydroxyethoxy rutile) is:

式中、Ｒ²¹〜Ｒ²⁸はＨ又はメチルから成る群から独立して、選択され、ここで、少なくとも１つのＲ²¹〜Ｒ²⁸はメチルである。 Another useful alkylated flavonoid compound, methyl hesperidin, has the general structural formula (V)

Wherein R ^{21 to} R ²⁸ are independently selected from the group consisting of H or methyl, wherein at least one R ^{21 to} R ²⁸ is methyl.

  Another useful group of glycoside flavonoids herein is chalcone, which can be obtained from any flavanone by isomerization. Chalcones are very useful in the present invention because of their improved solubility, which facilitates their incorporation into skin care compositions.

Typical chalcones derived from hesperidin are as follows.

Another representative chalcone derived from hesperitin is as follows.

  Commercially available flavonoid compounds include hesperidin, methyl hesperidin, and rutin available from Alps Pharmaceutical Industry Co. Ltd. (Japan), and Hayashibara Biochemical Laboratories, Inc. (Japan) And glucosyl hesperidin and glycosyl rutin available from Toyo Sugar Refining Co. Ltd (Japan).

Vitamin B3 Compound The composition comprises from about 0.01% to about 15%, preferably from about 0.1% to about 15%, more preferably from about 0.5% to about 10% vitamin B3 compound. Vitamin B3 compounds by themselves provide precursors for the nicotinamide adenine dinucleotide phosphate (NADP) family of coenzymes and their reduced form (NADPH) family that enhance many metabolic enzyme reactions in the skin. Are known. Vitamin B3 compounds are also known to provide reduced transdermal water loss and excess dermal glycosaminoglycans, which are indicators of skin barrier properties.

  Surprisingly, it has been found that using a combination of a flavonoid compound and a vitamin B3 compound results in a composition that provides a synergistic skin treatment effect over the use of either active agent alone. It was done. The skin treatment effect is particularly seen in the whitening effect and anti-aging effect.

  Without being bound by theory, flavonoid compounds are believed to enhance the transport properties of vitamin B3 compounds. Flavonoid compounds have a relatively good affinity for cell membrane lipid bilayers, while vitamin B3 compounds have a relatively low affinity due to their general hydrophilic structure. By effectively transporting the two types of active substances into the skin cells, the two types of active substances provide a skin treatment effect through different mechanisms within the dermis, thereby synergistic to the skin. The effect is considered to be provided.

  Useful vitamin B3 compounds herein include, for example, those having the following formula:

式中、Ｒは−ＣＯＮＨ₂（例えば、ナイアシンアミド）、又は−ＣＨ₂ＯＨ（例えば、ニコチニルアルコール）、これらの誘導体、及びそれらの塩である。前述のビタミンＢ₃化合物の代表的な誘導体としては、ニコチン酸の非血管拡張性エステル、ニコチニルアミノ酸、カルボン酸のニコチニルアルコールエステル、ニコチン酸Ｎ−オキシド、及びナイアシンアミドＮ−オキシドを包含する、ニコチン酸エステルが挙げられる。好ましいビタミンＢ₃化合物は、ナイアシンアミド及びニコチン酸トコフェロールであり、ナイアシンアミドがより好ましい。好ましい実施形態では、ビタミンＢ₃化合物は、限られた量の塩の形態を含有し、より好ましくは実質的にビタミンＢ₃化合物の塩を含まない。好ましくはビタミンＢ₃化合物は約５０％未満のそのような塩を含有し、更に好ましくは本質的には塩の形態を含まない。本明細書で極めて有用な市販のビタミンＢ₃化合物としては、ライリー（Reilly）から入手可能なナイアシンアミドＵＳＰが挙げられる。

In the formula, R is —CONH ₂ (for example, niacinamide), or —CH ₂ OH (for example, nicotinyl alcohol), derivatives thereof, and salts thereof. Representative derivatives of the aforementioned vitamin B ₃ compounds include non-vasodilator esters of nicotinic acid, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxide, and niacinamide N-oxide. And nicotinic acid esters. Preferred vitamin B ₃ compounds are niacinamide and tocopherol nicotinate, with niacinamide being more preferred. In a preferred embodiment, the vitamin B ₃ compound contains a limited amount of salt form, more preferably substantially free of vitamin B ₃ compound salt. Preferably the vitamin B ₃ compound contains less than about 50% of such salts, more preferably essentially free of salt forms. A commercially useful vitamin B ₃ compound that is very useful herein includes niacinamide USP available from Reilly.

Vitamin B6 compound The present composition is preferably from about 0.001% to about 15%, preferably from about 0.01% to about 10%, more preferably from about 0.01% to about 15% by weight of the composition. It further comprises 5% by weight of a vitamin B6 compound.

  Vitamin B6 compounds are known per se to provide coenzymes for the synthesis of amino acids and nucleic acids, thereby enhancing the anabolic activity, such as collagen synthesis, of skin cells. The improved collagen structure is known to provide good skin tone and a bright appearance of the skin.

  Surprisingly, it has been found that the use of a combination of a flavonoid compound and a vitamin B3 compound in addition to a vitamin B6 compound provides a composition that provides a significant skin treatment effect. The skin treatment effect is particularly seen in the whitening effect and anti-aging effect.

  Without being bound by theory, it is believed that the three types of active substances have an overall effect on the skin through different mechanisms in the dermis, which provides a synergistic benefit to the skin. It is done.

  Vitamin B6 compounds useful herein include pyridoxine, pyridoxine tripalitate, pyridoxine dipalmitate, pyridoxine esters such as pyridoxine dioctanoate, pyridoxine amines such as pyridoxamine, pyridoxine HCl And salts thereof such as pyridoxamine, pyridoxal, pyridoxal phosphate, and pyridoxine acid. Particularly useful vitamin B6 compounds are selected from the group consisting of pyridoxine, pyridoxine esters, and pyridoxine salts. Vitamin B6 compounds can be synthetic or naturally derived and can be used as essentially pure compounds or as mixtures of compounds (eg, extracts from natural sources or mixtures of synthetic substances). . As used herein, “vitamin B6” includes isomers and six tautomers of such. Commercially available vitamin B6 useful herein includes, for example, pyridoxine dipalmitate having the trade name NIKKOL DP available from Nikko Chemicals Co. Ltd, such as pyridoxine HCl available from DSM, And pyridoxine dioctanoate with the trade name Nikkor DK.

Oil-in-water carriers and composition forms The skin active agents of the present invention can be incorporated into various skin care compositions in the form of oil-in-water emulsions. The composition has a continuous aqueous phase and an identifiable non-continuous oil phase comprising an oil component, the oil component being at least 2% by weight of the total composition.

  The composition typically has a milky or turbid appearance, but is transparent or translucent by adjusting the oil droplets to a size of less than about 100 nm, preferably less than about 80 nm. Can be made. The size of the droplets can be determined using a laser scattering particle size distribution analyzer LA-910 (Horiba, Japan). Droplet size is measured after mixing the emulsion for 30 seconds at a temperature of 25 ° C. + / − 1 ° C. In one highly preferred embodiment, the composition has a more or less transparent appearance having an absorbance value of less than about 2 at a wavelength of 340 nm, preferably about 1 to about 1.5 at the same wavelength. Such transparent or translucent emulsions are often referred to by the name of microemulsions and are various, including PCT international patent applications WO 00/61083 and WO 02/58665 to achieve the desired droplet size. Are available and are incorporated herein by reference.

  Products using the composition include lotions, emulsions, creams, makeup bases, and liquid foundations. By incorporating a powder having specific characteristics, the composition may include the characteristics of a makeup composition.

Oily Component The composition of the present invention contains an oily component. The oily ingredients useful herein can deliver skin conditioning effects such as smoothness and softness to the skin. Oily components useful herein include, for example, C _7-40 linear and branched hydrocarbons such as aliphatic alcohols, silicone oils, mineral oils, petrolatum, isohexadecane, C _{1- 30} alcohol esters, glycerides, alkylene glycol esters, propoxylated and ethoxylated derivatives, sugar ester such as poly cotton seed fatty acid sucrose, vegetable oils such as coconut oil, hydrogenated vegetable oils, animal fats, and C _{4 to 20} polypropylene glycol Examples include alkyl ethers, _C1-20 carboxylic acid esters of polypropylene glycol, and di- _C8-30 alkyl ethers. Hydrophobic nonionic surfactants that are water insoluble and have an HLB value of less than 10 can be used as the oily component. Hydrophobic nonionic surfactants useful herein include, for example, cetearyl glucoside, steareth-2, laureth-4, sucrose cocoate, sorbitan monoisostearate, sorbitan diisostearate Sorbitan sesquiisostearate, sorbitan monooleate, sorbitan dioleate, sorbitan sesquioleate, glyceryl monoisostearate, glyceryl diisostearate, glyceryl sesquiisostearate, glyceryl monooleate, glyceryl di Oleate, glyceryl sesquioleate, diglyceryl diisostearate, diglyceryl dioleate, diglycerin monoisostearyl ether, diglycerin diisostearyl ether, and mixtures thereof. That.

In one preferred embodiment, the oily components are in that they provide a skin conditioning effect, and also that they can form a gel network with the emulsifier, thereby increasing viscosity, phase stability, and slippery feel. Is selected from aliphatic alcohols in that a conditioning effect is provided. The fatty alcohols useful herein are selected from the group consisting of saturated linear or branched C _12-30 fatty alcohols, saturated linear or branched C _12-30 diols and mixtures thereof. Saturated linear or branched aliphatic alcohols. Preferred fatty alcohols are cetyl alcohol, stearyl alcohol and mixtures thereof.

  In another preferred embodiment, the two or more oily components are selected from the group consisting of hydrocarbon oils, fatty acid esters, and silicone oils.

  The oily component is preferably from about 2% to about 50%, more preferably from about 2% to about 20%, even more preferably from about 2% to about 50% by weight in the composition in that it provides a skin conditioning effect such as smoothness. Is included at a concentration of about 2% to about 10% by weight.

Emulsifier The composition preferably includes an emulsifier to disperse the oil component into the aqueous phase. A wide variety of emulsifiers are available herein. Known or conventional emulsifiers can be used in the composition so long as the selected emulsifier is chemically and physically compatible with the essential components of the composition and provides the desired dispersion characteristics.

  Non-limiting examples of emulsifiers useful herein include sugar esters and polyesters, alkoxylated sugar esters and polyesters, C1-C30 fatty acid esters of C1-C30 fatty alcohols, C1-C30 fatty acids of C1-C30 fatty alcohols. Alkoxylated derivatives of esters, alkoxylated ethers of C1-C30 aliphatic alcohols, polyglyceryl esters of C1-C30 fatty acids, C1-C30 esters of polyols, C1-C30 ethers of polyols, alkyl phosphates, polyoxyalkylene aliphatic ether phosphates, There are various nonionic and anionic emulsifiers such as fatty acid amides, acyl lactylates, soaps, and mixtures thereof.

  Non-limiting examples of other emulsifiers for use herein include the following. Polyethylene glycol 20 sorbitan monolaurate (polysorbate 20), polyethylene glycol 5 soy sterol, steareth-20, cetealess-20, PPG-2 methyl glucose ether distearate, ceteth-10, polysorbate 80, cetyl phosphate, potassium cetyl phosphate, Diethanolamine cetyl phosphate, polysorbate 60, glyceryl stearate, PEG-100 stearate, polyoxyethylene 20 sorbitan trioleate (polysorbate 85), sorbitan monolaurate, polyoxyethylene 4-lauryl ether sodium stearate, polyglyceryl-4 isostearate Hexyl laurate, PPG-2 methyl glucose ether distearate, ceteth-10 Diethanolamine cetyl phosphate, glyceryl stearate, PEG40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, and mixtures thereof.

  In one highly preferred embodiment, the oil-in-water composition of the present invention provides a microemulsion that is transparent or translucent in appearance. Microemulsions can be formed by the choice of surfactant. Hereinafter, the selection of surfactant to provide the microemulsion is referred to as the “first surfactant system”. Preferably, the first surfactant system is liquid at 40 ° C, more preferably at 25 ° C.

  The first surfactant system is selected from the group consisting of polysorbate, polyoxyalkylene hydrogenated castor oil, polyglycerin alkyl ester having a C10-20 alkyl substituent, polyoxyethylene sterol, and polyoxyethylene hydrogenated sterol. One or more nonionic surfactants. The overall hydrophilic-lipophilic balance (HLB) of the first surfactant system is 10 or more, preferably about 12 or more, more preferably about 14 to about 20. Preferably, the first surfactant system consists essentially of a nonionic surfactant having an HLB of 10 or more, more preferably about 12 or more, and even more preferably about 14 to about 20.

  Examples of polyoxyalkylene hydrogenated castor oil useful herein include polyoxyethylene (20) hydrogenated castor oil, polyethylene (40) hydrogenated castor oil, and polyoxyethylene (100) hydrogenated castor oil. And polyoxyethylene hydrogenated castor oil having 20 to 100 moles of ethylene oxide.

  Polyglycerol alkyl esters having C10-20 alkyl substituents useful herein include, for example, 6-10 moles of glycerol, such as polyglyceryl-6 laurate, polyglyceryl-10 laurate, and polyglyceryl-10 stearate. The thing which has a unit is mentioned.

  Polysorbates useful herein include those having 20 to 80 moles of ethylene oxide such as, for example, polysorbate-20, polyborbate-40, polysorbate-60, and polysorbate-80.

  Polyethylene sterols and polyethylene-cured sterols useful herein include those having 10-30 moles of ethylene oxide, such as, for example, polyethylene (10) phytosterol, polyethylene (30) phytosterol, and polyethylene (20) cholesterol. It is done.

  Among the nonionic surfactants, polysorbate is preferable, and polysorbate-20, polysorbate-40, and a mixture thereof are more preferable.

Aqueous Carrier The composition of the present invention includes an aqueous carrier to provide a continuous phase. The carrier concentration and species are selected according to compatibility with other ingredients and other desired properties of the product. The aqueous carrier is preferably included in the composition at a concentration of from about 30% to about 98%, more preferably from about 50% to about 95%, even more preferably from about 70% to about 95% by weight. The

  Carriers useful in the present invention include water and aqueous solutions of lower alkyl alcohols. The lower alkyl alcohol useful herein is a monohydric alcohol having 1 to 6 carbons, more preferably ethanol. Preferably, the aqueous carrier is substantially water. Deionized water is preferably used. Water from natural sources including mineral cations can also be used depending on the desired properties of the product.

  The pH of the composition is preferably from about 4 to about 8. If a skin treatment is included in the liquid composition, the pH may be adjusted to a pH that provides optimal effectiveness of the active skin treatment. Buffers and other pH adjusting agents can be included to achieve the desired pH. Suitable pH adjusting agents herein include acetate, phosphate, citrate, triethanolamine and carbonate.

Viscosifier The composition may comprise a viscosity agent that imparts a viscosity of from about 500 mPa / s to about 1,000,000 mPa / s, preferably from about 1000 mPa / s to about 100,000 mPa / s. . The composition may have a wide range of viscosities. The term “water-soluble or water-miscible” with respect to the viscosity agent herein is dissolved and clear when dissolved in a sufficient amount of water with or without the aid of high temperatures and / or mixing. It relates to a compound that makes a simple solution.

  Carboxylic acid / carboxylate copolymers are useful herein. Since the carboxylic acid / carboxylate copolymer keeps the composition relatively clear and at a suitable viscosity without sticking or oiling the composition in use, the copolymer provides a microemulsion. Especially useful for. In addition, the carboxylic acid / carboxylate copolymer can disperse and stabilize these components in the present composition when water-insoluble components are included.

  Commercially available carboxylic acid / carboxylate copolymers useful herein include the following. All B. F. CTFA name acrylates / C10-30 with trade names of Pemulene TR-1, Pemulene TR-2, Carbopol 1342, Carbopol 1382 and Carbopol ETD2020, available from BF Goodrich Company Alkyl acrylate crosspolymer.

  A neutralizing agent may be included to neutralize the carboxylic acid / carboxylate copolymers herein. Non-limiting examples of such neutralizers include sodium hydroxide, potassium hydroxide, ammonium hydroxide, monoethanolamine, diethanolamine, triethanolamine, diisopropanolamine, aminomethylpropanol, tromethamine, tetrahydroxypropyl Examples include ethylenediamine and mixtures thereof.

  Cellulose derivative polymers are useful herein. Cellulose derivative polymers useful herein include methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxyethylethylcellulose, hydroxypropylmethylcellulose, nitrocellulose, sodium cellulose sulfate, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder and mixtures thereof. It is done. Particularly preferred are hydroxyethyl cellulose, carboxymethyl cellulose, and mixtures thereof. Commercially useful compounds useful herein include hydroxyethyl cellulose under the trade name Natrosol Hydroxyethylcellulose, carboxy under the trade name Aqualon Cellulose Gum, both available from Aqualon. Examples include methyl cellulose.

  Useful herein are vinyl polymers such as crosslinked acrylic acid polymers of the CTFA name Carbomer, pullulan, mannan, scleroglucan, polyvinylpyrrolidone, polyvinyl alcohol, guar gum, hydroxypropyl guar gum, xanthan gum, acacia Gum, gum arabic, tragacanth, galactan, carob gum, caraya gum, locust bean gum, carrageenin, pectin, amylopectin, agar, quince seed (Sydonia oblonga Mill), starch (rice, corn, potato, Wheat), algal colloids (algae extract), microbiological polymers such as dextran, succinoglucan, starches such as carboxymethyl starch and methylhydroxypropyl starch Polymers, alginate polymers such as sodium alginate, propylene glycol alginate, acrylate polymers such as sodium polyacrylate, polyacrylamide, polyethyleneimine, and the like bentonite, aluminum magnesium silicate, laponite, hectorite, and silicic anhydride Is an inorganic water-soluble substance.

  Polyalkylene glycols having a molecular weight greater than about 1000 are useful herein. Those having the following general formula are useful:

式中、Ｒ⁹⁵はＨ、メチル及びこれらの混合物から成る群から選択される。Ｒ⁹⁵がＨのときには、これらの物質は、ポリエチレンオキシド、ポリオキシエチレン、及びポリエチレングリコールとしても知られている、エチレンオキシドのポリマーである。Ｒ⁹⁵がメチルのときには、これらの物質は、ポリプロピレンオキシド、ポリオキシプロピレン、及びポリプロピレングリコールとしても知られている、プロピレンオキシドのポリマーである。また、Ｒ⁹⁵がメチルのときには、得られるポリマーの種々の位置異性体が存在し得ることも認識されている。上記構造では、ｘ３は、約１，５００〜約２５，０００、好ましくは約２，５００〜約２０，０００、より好ましくは約３，５００〜約１５，０００の平均値を有する。他の有用なポリマーとしては、ポリプロピレングリコール及び混合ポリエチレン−ポリプロピレングリコール、又はポリオキシエチレン−ポリオキシプロピレンコポリマーのポリマー類が挙げられる。本明細書で有用なポリエチレングリコールポリマーは、Ｒ⁹⁵がＨに等しく、ｘ３が約２，０００の平均値を有するＰＥＧ−２Ｍ（ＰＥＧ−２Ｍは、ユニオン・カーバイド（Union Carbide）から入手可能なポリオックス（Polyox）ＷＳＲ（登録商標）Ｎ−１０としても知られ、またＰＥＧ−２，０００としても知られる）、Ｒ⁹⁵がＨに等しく、ｘ３が約５，０００の平均値を有するＰＥＧ−５Ｍ（ＰＥＧ−５Ｍは、共にユニオン・カーバイドから入手可能なポリオックスＷＳＲ（登録商標）Ｎ−３５及びポリオックスＷＳＲ（登録商標）Ｎ−８０としても知られ、またＰＥＧ−５，０００及びポリエチレングリコール３００，０００としても知られる）、Ｒ⁹⁵がＨに等しく、ｘ３が約７，０００の平均値を有するＰＥＧ−７Ｍ（ＰＥＧ−７Ｍは、ユニオン・カーバイドから入手可能なポリオックスＷＳＲ（登録商標）Ｎ−７５０としても知られる）、Ｒ⁹⁵がＨに等しく、ｘ３が約９，０００の平均値を有するＰＥＧ−９Ｍ（ＰＥＧ−９Ｍは、ユニオン・カーバイドから入手可能なポリオックスＷＳＲ（登録商標）Ｎ−３３３３としても知られる）、並びにＲ⁹⁵がＨに等しく、ｘ３が約１４，０００の平均値を有するＰＥＧ−１４Ｍ（ＰＥＧ−１４Ｍは、ユニオン・カーバイドから入手可能なポリオックスＷＳＲ（登録商標）Ｎ−３０００としても知られる）である。

Wherein R ⁹⁵ is selected from the group consisting of H, methyl and mixtures thereof. When R ⁹⁵ is H, these materials are polymers of ethylene oxide, also known as polyethylene oxide, polyoxyethylene, and polyethylene glycol. When ^R95 is methyl, these materials are polymers of propylene oxide, also known as polypropylene oxide, polyoxypropylene, and polypropylene glycol. It is also recognized that when R ⁹⁵ is methyl, various regioisomers of the resulting polymer can exist. In the above structure, x3 has an average value of about 1,500 to about 25,000, preferably about 2,500 to about 20,000, more preferably about 3,500 to about 15,000. Other useful polymers include polypropylene glycol and mixed polyethylene-polypropylene glycol, or polyoxyethylene-polyoxypropylene copolymer polymers. The polyethylene glycol polymers useful herein are PEG-2M (PEG-2M is a polyhydride available from Union Carbide) with R ⁹⁵ equal to H and x3 having an average value of about 2,000. PEG-5M, also known as Polyox WSR® N-10, also known as PEG-2,000), R ⁹⁵ equals H and x3 has an average value of about 5,000 (PEG-5M is also known as Polyox WSR® N-35 and Polyox WSR® N-80, both available from Union Carbide, and also PEG-5,000 and polyethylene glycol 300 PEG-7M, where R ⁹⁵ is equal to H and x3 has an average value of about 7,000 (PEG-7M is PEG-9M (also known as Polyox WSR® N-750 available from On Carbide), R ⁹⁵ equals H, and x3 has an average value of about 9,000 (PEG-9M is Polyox WSR® N-3333 available from Union Carbide), as well as PEG-14M (PEG-14M is an average of about 14,000 with R ⁹⁵ equal to H and x3) Polyox WSR® N-3000 available from Union Carbide).

  Commercially available additional water-soluble polymers that are very useful herein include the brand name KELTROL series of xanthan gums, all available from Kelco. F. Trade names available from BF Goodrich Company carbopol 934, carbopol 940, carbopol 950, carbopol 980, and carbopole 981 carbomers available from Rohm and Hass ACRYSOL 22 acrylate / steares-20 methacrylate copolymer, trade name SEPIGEL 305 polyacrylamide available from Seppic, trade name LUBRAGEL NP glyceryl available from ISP Polymethacrylate and a mixture of glyceryl polymethacrylate, propylene glycol and PVM / MA copolymer under the trade name LUBRAGEL OIL, Michel Mercier Products Inc. (New Jersey, USA) Clerarogel SC11 cleroglucan available from Gee, all brand names CARBOWAX PEG, POLYOX WASR, and UCON FLUIDS supplied by Amerchol ) Of ethylene oxide and / or propylene oxide.

  MERQUAT 280, polyquaternium 22 with mark 295, MERQUAT PLUS 3330, polyquaternium 39 with MARK PLUS 3331, and products Commercially available amphoteric polymers such as polyquaternium 47 having the names Markatt 2001, Markatt 2001N are useful herein, all of which are available from Calgon Corporation.

Water-soluble humectants The compositions of the present invention may further comprise from about 0.1% to about 30%, preferably from about 3% to about 15% of a water-soluble humectant. Water-soluble humectants useful herein include polyhydric alcohols such as butylene glycol (1,3 butanediol), pentylene glycol (1,2-pentanediol), glycerin, sorbitol, propylene glycol, hexylene. Glycol, ethoxylated glucose, 1,2-hexanediol, 1,2-pentanediol, hexanetriol, dipropylene glycol, erythritol, trehalose, diglycerin, xylitol, maltitol, maltose, glucose, fructose, and other water solutions Compounds such as urea, sodium chondroitin sulfate, sodium hyaluronate, sodium adenosin phosphate, sodium lactate, pyrrolidone carbonate, glucosamine, cyclodextrin Phosphorus and mixtures thereof are mentioned. Also useful herein are polyethylene glycols and polypropylene glycols having molecular weights up to about 1000, such as those with CTFA names of PEG-200, PEG-400, PEG-600, PEG-1000, and mixtures thereof. And water-soluble alkoxylated nonionic polymers such as

  The following are mentioned as a commercially available moisturizing agent in this specification. Trade name 1,3-butylene glycol available from Celanese, Butylene glycol available from Dragoco, Pentylene glycol available from Dragoco, HYDROLITE-5, Procter Trade names STAR and SUPEROL available from The Procter & Gamble Company, Croderol GA7000 available from Croda Universal Ltd., Unikema The brand name Rexol PG-865 / 855 (LEXOL PG available from Inolex) under the same trade name as the chemical name available from NOF, as well as the PRECERIN series available from (Unichema) -865/855), 1,2-propylene glycol USP available from BASF 1,2-PROPYLENE GLYCOL USP), Propylene glycol, Liponic series available from Lipo, SORBO available from ICI, ALEX, A-625, and A -641, and UNISWEET 70, UNISWEET CONC available from UPI, sorbitol, also available from BASF under the same dipropylene glycol, Solvay GmbH DIGLYCEROL diglycerin, Kyowa and Eizai also have the same brand name xylitol, trade name Malbit maltitol available from Hayashibara The trademark names available from Freeman and Bioiberica are the same and -Trade name of ATOMERGIC SODIUM CHONDROITIN SULFATE, available from Atomergic Chemetals, sodium chondroitin sulfate, available from Chisso Corp., Active Organics Trade names available from Organics ACTIMOIST, AVIAN SODIUM HYALURONATE series available from Intergen, hyaluronics available from Ichimaru Pharcos Sodium adenosin phophate of HYALURONIC ACID Na, which has the same brand name available from sodium hyaluronate, Asahikasei, Kyowa, and Daiichi Seiyaku, The trade names available from Merck, Wako, and Showa Kako are also the same sodium lactate, trade names available from American Maize, CAVITRON, and Rhône Poulin. RHODOCAP series available from (Rhone-Poulenc), and DEXPEARL available from Tomen, cyclodextrin, trade name Carbowax (available from Union Carbide) CARBOWAX series polyethylene glycol and a mixture of glyceryl polymethacrylate, propylene glycol and PVM / MA copolymer under the trade name Lubrajel Oil available from Guardian Lab.

Additional Skin Active Agent The compositions of the present invention may further comprise a safe and effective amount of an additional skin active agent. Skin active agents useful herein include whitening agents, anti-acne agents, emollients, non-steroidal anti-inflammatory agents, local anesthetics, artificial tanning agents, antiseptics, antibacterial and antifungal active substances, skin sedation Agent, sunscreen agent, skin barrier repair agent, wrinkle prevention agent, skin atrophy prevention active substance, lipid, sebum inhibitory substance, sebum inhibitory substance, skin sensory agent, proteolytic enzyme inhibitory substance, skin tightening agent, anti-itch agent Hair inhibitory substances, desquamating enzyme fortifiers, anti-glycation agents, and mixtures thereof. When included, the composition comprises from about 0.001% to about 30%, preferably from about 0.001% to about 10% of an additional skin active agent.

  The type and amount of skin active agent is selected so that the inclusion of a specific agent does not affect the stability of the composition.

  Whitening agents useful herein refer to active ingredients that improve pigmentation when compared to before treatment. Whitening agents useful herein include ascorbic acid compounds, azelaic acid, butylhydroxyanisole, gallic acid and its derivatives, glycyrrhizic acid, hydroquinone, kojic acid, arbutin, mulberry extract, and mixtures thereof. The use of a combination of whitening agents is considered advantageous in that they may provide a whitening effect by different mechanisms.

  Ascorbic acid compounds useful herein include essentially L-form ascorbic acid, ascorbate, and derivatives thereof. Ascorbates useful herein include sodium, potassium, lithium, calcium, magnesium, barium, ammonium and protamine salts. Ascorbic acid derivatives useful herein include, for example, esters of ascorbic acid and ester salts of ascorbic acid. Particularly preferred ascorbic acid compounds include 2-o-D-glucopyranosyl-L-ascorbic acid (an ester of ascorbic acid and glucose, commonly referred to as L-ascorbic acid 2-glucoside or ascorbyl glucoside) and its metal Salts, and L-ascorbic acid phosphate ester salts such as sodium ascorbyl phosphate, potassium ascorbyl phosphate, magnesium ascorbyl phosphate, and calcium ascorbyl phosphate. Commercially available ascorbic acid compounds include magnesium ascorbyl phosphate available from Showa Denko, 2-o-α-D-glucopyranosyl-L-ascorbic acid available from Hayashibara, and DSM. A possible trade name is STAY C50 sodium L-ascorbyl phosphate.

  Other hydrophobic whitening agents useful herein include ascorbic acid derivatives such as ascorbyl tetraisopalmitate (eg, VC-IP available from Nikko Chemical), ascorbyl palmitate (eg, DSM) Ascorbyl dipalmitate (eg, NIKKOL CP available from Nikko Chemical), undecylenoyl phenylalanine (eg, SEPIWHITE MSH available from Seppic), Octadecenedioic acid (eg, ARLATONE DIOIC DCA available from Uniquema, oenothera biennis sead extract, and pyrus malus (apple) fruit extract, and These mixtures are mentioned.

  Other skin active agents useful herein include panthenol, benzoyl peroxide, 3-hydroxybenzoic acid, farnesol, phytantriol, glycolic acid, lactic acid, 4-hydroxybenzoic acid, acetylsalicylic acid, 2-hydroxy Butanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, cis-retinoic acid, trans-retinoic acid, retinol, retinyl ester (eg retinylpropionate), phytic acid, N-acetyl-L-cysteine , Lipoic acid, tocopherol and its esters (eg, tocopheryl acetate), azelaic acid, arachidonic acid, tetracycline, ibuprofen, naproxen, ketoprofen, hydrocortisone, acetaminophen, resorcinol, phenoxy Cyethanol, phenoxypropanol, phenoxyisopropanol, 2,4,4′-trichloro-2′-hydroxydiphenyl ether, 3,4,4′-trichlorocarbanilide, octopirox, lidocaine hydrochloride, clotrimazole, miconazole, ketoconazole , Neomycin sulfate, theophylline, and mixtures thereof.

UV Absorber The composition of the present invention may further comprise a safe and effective amount of a UV absorber. A wide variety of conventional UV protection agents are suitable for use herein, such as US Pat. No. 5,087,445 (Haffey et al., Issued February 11, 1992), US Pat. No. 5,073,372 (Turner et al., Issued Dec. 17, 1991), US Pat. No. 5,073,371 (Turner et al., Issued Dec. 17, 1991), and SEGARIN ( Segarin et al., Cosmetics Science and Technology (1972), Chapter 8, pages 189 et seq. When included, the composition comprises from about 0.5% to about 20%, preferably from about 1% to about 15% UV absorber.

  UV absorbers useful herein include, for example, 2-ethylhexyl-p-methoxycinnamate (commercially available as PARSOL MCX), butylmethoxydibenzoyl-methane, 2-hydroxy-4-methoxy. Benzo-phenone, 2-phenylbenzimidazole-5-sulfonic acid, octyldimethyl-p-aminobenzoic acid, octocrylene, 2-ethylhexyl N, N-dimethyl-p-aminobenzoate, p-aminobenzoic acid, 2-phenylbenz Imidazole-5-sulfonic acid, octocrylene, oxybenzone, homomenthyl salicylate, octyl salicylate, 4,4′-methoxy-t-butyldibenzoylmethane, 4-isopropyldibenzoylmethane, 3-benzylidene camphor, 3- (4-methylbenzylidene N) camphor, Eusolex® 6300, Octocrylene, Avobenzone (commercially available as Parsol 1789), and mixtures thereof.

Additional Ingredients The compositions herein are, for example, sensory effects, therapeutic effects, or prophylaxis related to appearance, smell, or feel to the composition or skin, as conventionally used in topical products. Additional ingredients may be further included to provide aesthetic or functional effects such as aesthetic effects. It should be understood that the required materials described above may provide such effects on their own.

  Examples of suitable topical ingredients include anti-cellulite agents, antioxidants, radical scavengers, chelating agents, vitamins and their derivatives, abrasives, other oil absorbents, astringents, dyes, essential oils, fragrances, structures Agents, emulsifiers, solubilizers, anti-caking agents, antifoaming agents, binders, buffers, fillers, modifiers, pH adjusters, propellants, reducing agents, sequestering agents, biocides for cosmetics, and preservatives Is mentioned.

  The following examples further describe and demonstrate embodiments within the scope of the present invention. These examples are presented for illustrative purposes only, and many variations are possible without departing from the spirit and scope of the invention, and should not be construed as limiting the invention. Absent. Ingredients are identified by chemical name or CTFA name, where applicable, otherwise defined below.

Definition of ingredients
^* 1 Niacinamide: Available from Niacinamide USP, DSM
^* 2 Glucosyl hesperidin: available from alpha-Ghesperidin PS-CC, Toyo Sugar Refining
^* 3 Rutin: available from Alps Pharmaceutical Industry
^* 4 Pyridoxine palmitate: available from Nikkol DP, Nikko Chemicals
^* 5 Poly cottonseed fatty acid sucrose: available from Kobo Products Inc.
^* 6 Polyacrylamide: Sepigel 305, available from SEPPIC Inc.
^* 7 Acrylate / C10-30 alkyl acrylate crosspolymer: Pemulen TR-2, B.I. F. Available from BF Goodrich
^* 8 Xanthan gum: available from Keltrol and Kelco
^* 9 Cetearyl glucoside: Emulgade PL68 / 50, available from Cognis
^* 10 PEG-100 stearate: Myrj 59P, available from Uniqema
^* 11 Dimethicone and Dimethiconol: DC Q2-1503 fluid, available from Dow Chemicals
^* 12 Tocopheryl acetate: available from Eisai Co. Ltd.
^* 13 Panthenol: D-Panthenol, available from DSM
^* 14 Ascorbyl sodium phosphate: Available from Stay-C50, DSM
^* 15 Mulberry extract: available from Mulberry extract BG, Maruzen Pharmaceuticals
^* 16 Ginkgo biloba extract: available from Ginkgo Extract BG, Maruzen Pharmaceuticals
^* 17 Promatrixyl: mixture contains Palmitoyl Pentapeptide-3, available from Sederma, Inc.
^* 18 Polymethylsilesquioxane: Tospearl 145A, available from GE Toshiba
^* 19 Zinc oxide, Z-Cote HP1, available from BASF Corp.
^* 20 Polyethylene: Microthene FN510-00, available from Equistar Chemicals
^* 21 Saccharomycopsis enzyme filtrate: available from SKII Pitera and Kashiwayama

Method of Preparation The above composition can be made by any method known to those skilled in the art. The composition is suitably manufactured as follows.
(1) Any oily component and hydrophilic surfactant are mixed in a container, and when a solid oily component is included, it is heated to 70 ° C. or higher until it melts. If ZnO or other inorganic powder is included, it is also dispersed into the oil phase.
(2) Water-soluble and heat-stable components other than the water-soluble thickening polymer are dissolved in water in a separate container and heated to 70 ° C. or higher.
(3) The products of steps (1) and (2) are mixed using a high speed mixer, a mill or a homogenizer, and mixed homogeneously.
(4) Add the water soluble thickening polymer to the product of step (3) and mix until homogeneous.
(5) If polyethylene beads are included, add it to the above mixture and mix.
(6) The product of step (5) is cooled to 40 ° C. or lower.
(7) All other water soluble components such as niacinamide, glucosyl hesperidin, extract, etc. are dissolved in water and added to the mixture of step (6).
(8) If other remaining ingredients such as perfume and Saccharomycopsis enzyme filtrate are included, add them to the product of step (6).

  These embodiments, represented by the foregoing examples, are useful as skin care products. When applied to facial skin, they offer many benefits. For example, they can provide improvements in areas of skin tone, skin lightening, skin whitening, skin yellowing reduction, and fine wrinkle reduction. A significant improvement in the above effects is observed when the examples are used daily for at least 4 weeks.

  All references cited in the “Best Mode for Carrying Out the Invention” are incorporated herein by reference in their relevant part, but any reference to a document is accepted as being prior art with respect to the present invention. Should not be interpreted. To the extent that any meaning or definition of a term in this document conflicts with any meaning or definition of a term in a document incorporated by reference, the meaning or definition given to the term in this document applies.

  While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. Accordingly, it is intended to embrace all such changes and modifications that fall within the scope of the invention within the scope of the appended claims.

Claims (10)

(1) about 0.001% to about 10% of a flavonoid compound,
A skin care composition comprising (2) 0.01% to about 15% vitamin B3 compound, and (3) a dermatologically acceptable oil-in-water carrier comprising at least about 2% oil component of the total composition. A thing,
The composition is a skin care composition substantially free of titanium dioxide.   2. The composition of claim 1, further comprising 0.001% to about 15% vitamin B6 compound.   2. The composition of claim 1, wherein the flavonoid compound is selected from the group consisting of substituted flavanones, substituted flavones, substituted chalcones, substituted isoflavones, and mixtures thereof.   4. The composition of claim 3, wherein the flavonoid compound is selected from the group consisting of glucosyl hesperidin, glucosyl rutin, glucosyl myristitrin, glucosyl isoquercitrin, glucosyl ercitrin, methyl hesperidin, and mixtures thereof. The carrier
(A) oily component,
(B) an emulsifier,
The composition according to claim 1, comprising (c) a viscosity agent, and (d) water.   The composition according to claim 5, wherein the thickening agent comprises an acrylic polymer. The carrier
(A) two or more selected from the group consisting of polyoxyalkylene alkyl ethers having a C _12-18 alkyl substituent, polyoxyalkylene hydrogenated castor oil, and linear or branched mono- or tri-alkyl glycerides An emulsifier comprising a nonionic surfactant of
(B) an oily component selected from the group consisting of hydrocarbon oils, fatty acid esters, silicone oils, and mixtures thereof;
(C) a thickening agent comprising a carboxylic acid / carboxylate copolymer;
(D) a water-soluble humectant, and (e) water,
The composition of claim 1, wherein the composition has an absorbance value of less than about 2 at a wavelength of 340 nm.   8. The composition of claim 7, wherein at least one of the nonionic surfactants has 10 or more HLBs, and at least one of the nonionic surfactants has an HLB of less than 10. .   A method for whitening the skin, comprising applying the composition according to claim 1 to the skin.   A method for providing an anti-aging effect to the skin, comprising applying the composition of claim 1 to the skin.