JP2008308499A - Combined drug for attaining three principles of non-illness, health and vitality to maintain life up to 100 years old - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a combined drug for attaining three principles of non-illness, health, and vitality to maintain life up to 100 years old. <P>SOLUTION: HARP-A comprises a chondroitin sulfate sodium salt, γ-linoleic acid, an aged garlic extract, a placenta extract, and vitamin B<SB>6</SB>. Alternatively, HARP-B comprises a chondroitin sulfate sodium salt, γ-linoleic acid, an aged garlic extract, and vitamin B<SB>6</SB>. HARP-KK further comprises an oyster shell powder heat treated for acceleration of absorption and an oyster extract. These drugs are administered with performing dietetic therapy and kinesitherapy. The above drugs are effective as preventive agents for cancer, cerebral infarction, myocardial infarction and the like. The drugs also have GH secretion acceleration, a biological defense effect against foreign substances and the like and can thereby construct a more healthy biological tissue structure and can achieve the reinforcement of the immune function. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention does not belong to the medical field, but establishes a healing induction and prevention effect in the previous stage of medical treatment, and achieves a higher level of fundamental constitution improvement, that is, non-disease, health and vitality. It belongs to the technical field related to the construction of healthy human anatomy. HARP-A or HARP-B In addition to taking HARP-KK as needed, a balanced diet, moderate exercise, adequate sleep, etc. are necessary requirements.

  [Claim 3] Stem cells that exist to protect the human body are soundly strengthened by HARP-A, HARP-B, and HARP-KK, and particularly, GH and IGF-1 by supplementing nucleic acid and enhancing cyclic AMP production are enhanced. DNA reformation is achieved with the promotion of secretion, and normal and healthy cells are induced to differentiate from healthy stem cells to form a healthy tissue structure. By continuing a healthy and enjoyable and fulfilling life, stem cell DNA reforms will spontaneously take place. This is the basis for maintaining the homeostasis of the human body.

The establishment of immune reserve by strengthening the intestinal immune mechanism generated in the small intestinal epithelial tissue according to “claim 4”, “claim 5” and “claim 6” does not belong to the medical field but is in the previous stage. Belongs to advanced technical field. The immune response, correct immune response, and attack power against foreign bodies are all established, and the original immunity is established, but the action of HARP-A, HARP-B, and HARP-KK fulfills this requirement without requiring the thymus. ing.
In particular, the fact that T cells with specific immunity are generated in the small intestinal epithelial tissue and matured regardless of the thymus is a devastating thing. Furthermore, when antigen sensitization is performed, the importance of intestinal immunity is suggested by the fact that the amount of T cells present in the intestinal mucosa fixed layer corresponds to 70 to 80% of the whole organism. The newborn living body promotes intestinal peristalsis by γ-linolenic acid contained in breast milk, enhances blood flow in the small intestinal epithelial mucosa, strengthens the intestinal immune mechanism, and strengthens the defense power against foreign substances in the living body itself. The fact that the aging body is reduced to 10% of the peak due to atrophy of the thymus, the incidence of cancer and autoimmune diseases is high, and the rate of death due to pneumonia is high. The enhancement of intestinal immune function by γ-linolenic acid in HARP-A or HARP-B can be performed from T cell generation to maturation without depending on the bone marrow or thymus, so it is significant for aging organisms At the same time there is something, it becomes the basis for achieving the three principles of non-disease, health and vitality.

[Claim 7] Growth hormone having a strong affinity of PGE ₁ produced from HARP-A or HARP-B-containing component γ-linolenic acid is an important factor for restoring human tissue.
It is safe when the health of the living body is established by stem cell DNA reform at an early stage, but growth hormone secretion when the start of taking HARP-A or HARP-B is delayed and aging is in progress The revitalization and restoration of living tissues through promotion has significant significance.
The animal dies as soon as the reproductive phase ends, but in the human body, for example, in the case of a woman, youthfulness, vitality restoration, and feminine attraction are restored by promoting growth hormone secretion even after menopause. The most favorable state appears. Even in men, it is possible to develop muscles by training after seeing the youth and revitalization of vitality.
This phenomenal phenomenon can be ensured by satisfying the following requirements.
Increase protein intake. Avoid excessive intake of carbohydrates and maintain blood sugar levels in normal or slightly lower eyes. A little stronger exercise is needed by accustoming the exercise little by little. Mental stimulation vitality is necessary. Deep sleep is also important. Growth hormone is secreted a lot during slow wave sleep. The objective is to achieve the three principles of non-disease, health, and vitality by using HARP-A, HARP-B, and HARP-KK, and to maintain it until the age of 100.

[Claim 8] Arteriosclerosis is the most important risk factor for the human body. Cerebral infarction and myocardial infarction occupy the top mortality and are on the rise. The brain and heart are the organs that consume the most budo sugar and oxygen in the human body. The brain stem controls the heart, and the heart replenishes the brain with budo sugar and oxygen through blood vessels. Therefore, both functions are closely related to each other, and are related to the advanced technical field that transcends the medical technical field in terms of preventing cerebral and cardiac vascular disorders and further inducing the cure of the generated arteriosclerosis.
The arteriosclerosis preventing and ameliorating action of HARP-A, HARP-B, and HARP-KK in the high technical field is exhibited by a powerful specific function.
(1) It exhibits a powerful arterial vasodilatory action and blood flow promoting action on each visceral tissue including brain, heart, mainly chondroitin sulfate sodium and γ-linolenic acid in HARP-A or HARP-B-containing components. Furthermore, it exerts vascular wall strengthening action, repair and regenerative action against vascular wall degeneration. Moreover, microvascular blood flow promotion and angiogenesis action are expressed by improving red blood cell change function.
(2) The action of mainly γ-linolenic acid and aged garlic extract maintains normal cholesterol levels and increases good cholesterol HDL.
(3) Hypertension is improved mainly by the action of γ-linolenic acid and ionized calcium in the processed oyster powder, and it is always possible to keep it below the normal value. This effect is particularly pronounced at diastolic blood pressure.
(4) Hyperlipidemia, which is a cause of arteriosclerosis, is caused by abnormalities in lipoprotein metabolism, but GH having strong affinity with PGE ₁ directly acts on adipose tissue to suppress fat synthesis. Promotes lipolysis and reduces visceral fat.
The above action is fundamental and constitutional improvement, and there is no substance having other action.
It is a serious invention.

“Claim 9” is a human body remodeling theory by improving brain tissue structure and strengthening tissue function, and belongs to the advanced technical field that transcends the medical field. If it is possible to restore the same brain tissue structure and tissue function as a young human living body, the rejuvenation of the human living body and vitalization of the biological function are automatically achieved. In this sense, HARP-A, HARP-B, and HARP-KK are unique materials that exhibit significance for improving brain tissue structure and strengthening tissue function.
The above facts are confirmed by the following items.
(1) The brain stem has the functions that are absolutely necessary to maintain life and controls the human body. It exerts a powerful arterial vasodilatation and arterial blood flow promoting action to sufficiently supply the budose sugar and oxygen, which are the basis of this brainstem function enhancement. In addition, the auxiliary blood flow promoting action is also significant.
(2) The brain stem directly dominates functions such as heart, blood vessels, swallowing, sleep, breathing, defecation, and urination. Strong arterial blood flow and auxiliary blood flow for internal organs responsible for these functions The tissue revival with the enhancement as the core and the backflow phenomenon by expressing the function enhancing action occur, and the brainstem action is made smoother and stronger.
(3) One action after the brainstem is an autonomic nerve control action, but the hypothalamus is also directly related to this action. The autonomic nervous system is composed of the sympathetic nerve and the parasympathetic scattered intestinal nerve. These function independently in the human body regardless of their will. In particular, sympathetic nerves and parasympathetic nerves maintain their biological functions in a normal state while regulating their actions.
Since this PGE ₁ produced from γ-linolenic acid directly dominates via the hypothalamus, this autonomic nervous function regulating action directly contributes to brainstem function enhancement.
The increase or decrease in blood pressure is due to sympathetic nerves and parasympathetic nerves, and is directly under the control of PGE ₁ via the hypothalamus.
(4) It is not an exaggeration to say that the brain tissue is mostly composed of unsaturated cellular acids, and contains as many unsaturated fatty acids. In this regard, the antioxidant effect of the aging garlic extract plays a significant role by preventing the formation of lipid peroxides.
(5) nerve cells at the human body is said to be reduced by 10 million pieces every day, that vitamin B ₆ acts suppression manner is generally accepted. Aged garlic extract was also confirmed to have the same function, and the synergistic action of both has significant significance. Furthermore, this action is completed by a GH secretion promoting action that enhances protein synthesis.
Furthermore, GH and IGF-1 are produced in most parts of the brain, and GH receptors are widely present in the central nervous system, but are particularly present in the hippocampus and exert their nerve cell proliferating function. Restores hippocampal tissue that has been shrunken due to strong stress, etc., and restores memory and cognitive brain. Many IGF-1 receptors are also present in the hippocampus and exert similar effects.
Many people have confirmed the resurrection of memory and cognitive brains. The above facts are not in the medical field, but have been completed by activating the functions of the human living body, and the best breakthrough invention is disclosed.

[Claim 10] In the invention group for the purpose of achieving the three principles of non-disease, health and vitality by HARP-A, HARP-B, and HARP-KK and maintaining it until the age of 100, cancer The technical field in the pre-medical stage is the most important and important invention.
It takes about 9 years for a 1 mm diameter cancer to grow into a 1 centimeter diameter cancer cell population, but the stem cells of the cell tissue in which cancer has developed over such a long period of time have caused DNA degeneration, Cells that have become cancerous by inducing differentiation of cancerous cells continue to divide more and more. Furthermore, the tissue stem cells denatured with DNA generate immunosuppressive substances to protect the already denatured self, the balance between helper T cells and suppressor T cells is broken, and the immune function of the living body is greatly reduced.
After this stage, it belongs to the medical field, and treatment other than complete excision of the cancer tissue group is extremely difficult. Although medical progress has been remarkable, the future is still severe in the technical field of cancer treatment.
In this sense, it is an epoch-making invention to induce cancer to cure in the previous stage of the medical technical field of cancer treatment.
(1) PGE ₁ produced from γ-linolenic acid increases cyclic AMP of various cancer cells, induces differentiation into normal cells, and suppresses their proliferation.
(2) Differentiating induction of healthy T cells, B cells, and NK cells from lymphoid stem cells by increasing bone mass, promoting bone blood flow, and enhancing bone marrow tissue regeneration function with HARP-A, HARP-, or HARP-KK.
(3) Immunity surplus is established by strengthening the intestinal immune mechanism by promoting small intestinal peristaltic movement by PGE ₁ produced from γ-linolenic acid and by promoting small intestinal mucosal blood flow.
(4) Nucleic acid is replenished with HARP-KK in order not to be damaged or distorted when DNA is copied during cell division. Furthermore, ionized calcium in HARP-KK promotes migration of macrophages that are differentiated from myeloid stem cells.
As described above, the cancer cell generation inhibitory effect is exhibited, and natural healing power is exhibited by taking HARP-A, HARP-B, or HARP-KK within a certain period.

[Claim 11] Inflammation and immunity are integrated, and no other substance such as HARP-A, HARP-B, or HARP-KK has both an anti-inflammatory action and an immune enhancing action. PGE ₁ produced from γ-linolenic acid via γ-dihomolinolenic acid is similar to PGE _{2 and} other PGs belonging to the arachidonic acid cascade, but the mechanism of action is mainly different. Normally, PGE ₁ PGE ₂ is produced by macrophages and the like, and exerts immune tolerance and immune response regulation in the thymus, but in fact, T cells are matured and mobilized to the necessary tissues and reach their maximum values. The production of PGE ₁ PGE ₂ is already inhibited by macrophages. PGE ₂ is independent of the immune enhancing effect. When HARP-A, HARP-B, or HARP-KK is continuously taken, PGE ₁ produced as necessary from γ-linolenic acid activates adenylate cyclase present in the cell membrane, By increasing the cyclic AMP and suppressing the release of the chemical substances histamine and SRM-A, which cause inflammation, from the cytoplasm, the increase in the permeability of the blood vessel wall is suppressed.
Bone marrow thymus immune mechanism that exerts anti-inflammatory action as described above, but forms the mainstream of immunity by inducing differentiation of healthy T cells, B cells, and NK cells from lymphoid stem cells by enhancing bone marrow function And the establishment of the intestinal immunity mechanism by strengthening the small intestinal epithelial tissue, the immune function of the living body is enhanced. As described above, maintaining immunity and exerting a powerful anti-inflammatory effect is significant, but in the case of inflammation, leukocytes, mainly neutrophils, can easily exudate from the blood vessels. Because of this, increased permeability of the blood vessel wall occurs. Normally, leukocytes digest carcinogens and other substances by phagocytosis and lysosomes, and also melt tissue disintegrating components.
When inflammatory exudation is severe, tissue destruction such as tissue infarction and necrosis progresses, and in particular, mononuclear cells such as macrophages may be added to cause a crisis state in the human body. In this sense, anti-inflammatory action by HARP-A, HARP-B, and HARP-KK is essential for maintaining the homeostasis of the human body, and achieves the three principles of non-disease, health, and vitality. It becomes an important factor for

[Claim 12] With respect to autoimmune diseases, the treatment is not only difficult, but may be life-threatening. Deterrence in the pre-treatment phase is the most important, and because it is delayed, it is the most important important technical field in the pre-treatment phase that induces palliative control even if the occurrence of the disease is observed. Belongs.
HARP-A, HARP-B, and HARP-KK are mild with respect to autoimmune diseases, but with severe differences, they mean that the immune system of the human body is abnormal, and in the extreme case, the state of the immune system is broken .
Bone marrow is the only tissue that can revive dysfunctional lymphoid tissues caused by X-ray irradiation, severe illnesses, and other causes. The state of failure of the biological immune system is restored and normalized.
Contrary to this fact, abnormal T cells, B cells, and NK cells are differentiated and generated by bone marrow stem cell DNA degeneration, which should be the basis of the immune mechanism, causing abnormalities in the biological immune mechanism, and various autoimmunity. Causes the occurrence of disease. In particular, abnormal progenitor T cells are unable to undergo normal ripening due to immune tolerance and immune response regulation even in a healthy thymus, causing lymphokine abnormalities, and B This leads to the appearance of cell abnormalities and macrophage functional abnormalities.
Since bone marrow can only revive lymphoid tissue by inducing differentiation of healthy lymphocytes from lymphoid stem cells, it is T cells that ultimately control the immune function of the body. . Thus, T cells play a central role in bioimmunity. However, in autoimmune diseases, the symptoms are different, but the common thing is that autoreactive T cells are activated. The autoimmune phenomenon is triggered by specific virus infections such as streptococci and retroviruses, but once the autoreactive T cells are activated, these viruses Generation of antibodies against the virus is also observed, and tissue destruction rapidly proceeds by self-antigen expression and promotion of production of inflammatory cytokines regardless of virus infection. Furthermore, various symptoms are formed by the physiological phenomenon of the produced cytokine.
In the field of the present invention, a preventive action and an early healing induction action are surely exhibited. There is no possibility of viral infection due to the strengthening of the bone marrow thymus immune system and the intestinal immune system. Furthermore, regarding the generation of autoantibodies and the activation of autoreactive T cells, in the thymus, PGE ₁ enhances cAMP, thereby tolerating the immune response of T cells together with PGE ₂ through thymic hormones and macrophages, immune attack It demonstrates the adjustment function.
Since the production of PGE ₁ and PGE ₂ must be suppressed to activate autoimmune T cells, the supply of γ-linolenic acid increases the level of PGE ₁ and suppresses activation of autoimmune T cells. The action naturally and clearly exhibits a significant action, and there is a remarkable aspect of the present invention.
Furthermore, regarding the generation of autoantibodies, B cells need the help of helper T cells for antibody production, so this part also belongs to the field of the present invention.
Although corticosteroids and glucocorticoids are often used for diagnosis and treatment of autoimmune diseases, they are only symptomatic treatments, but HARP-A or HARP-B retains immunity and exerts anti-inflammatory effects. It activates adenylyl cyclase present in the cell membrane to enhance cyclic AMP, inhibits the release of histamine, SRM-A, etc., inhibits the increase in vascular permeability, and exerts a mild deterrent effect.
The above suggests the necessity and importance of autoimmune diseases caused by HARP-A, HARP-B, and HARP-KK, and achieves the three principles of maintaining homeostasis, non-disease, health, and vitality of the human body. As a result, it becomes a serious invention.

“Claim 13” is an aging progression suppression theory. In the technical field within the scope of the present invention, non-disease, health by HARP-A, or HARP-B, HARP-KK, except for the part where degeneration occurs, which is fixed to a part of the living body. The achievement of the three principles of vitality is established, and the goal is to maintain it until the age of 100.
The aging biological phenomenon of walking with a cane due to the fact that the back is actually bent and the legs and legs are weakened is essentially a wrong phenomenon. The occurrence of such a phenomenon cannot be 100% due to cartilage strengthening.
(Important matter) γ-linolenic acid and PGE ₁ are separate, and γ-linolenic acid also has a unique mechanism of action, and generates PGE ₁ as necessary. Since ATP is produced in all internal organs and tissues, PGE ₁ activates adenyl cyclase present in the cell membrane to produce cyclic AMP, and GH and IGF-1 differentiate and proliferate healthy cells. By maintaining and sustaining a healthy and vigorous state, the stem cell DNA of all internal organs and tissues is reformed spontaneously, and healthy vital cells are differentiated and induced. As a result, the soundness and vitality of all internal organs can be maintained and sustained. Each tissue stem cell exists for the purpose of protecting and protecting the human living body, and as a result, maintains a state that suppresses the aging of the human living body. The brain and heart are organs necessary for maintaining the life of the human body, and govern the health of the human body. The brain and heart both consume 50% or more of the oxygen-budo sugar of the human body, but PGE ₁ and sodium chondroitin sulfate contribute to the enhancement of the function by arterial vasodilation and blood flow promoting action.
This effect is further enhanced by taking aged garlic extract and light sustained exercise. Furthermore, by slightly increasing exercise, increasing protein intake, mental stimulation, and keeping blood sugar as low as possible, secretion of GH with the strongest affinity with PGE ₁ is promoted, and GH is further in the liver. Stimulates the production of IGF-1 and suppresses the differentiation, proliferation, and cell death of healthy cells not only by the growth promoting action but also by the metabolic action of proteins, lipids, sugars, and water electrolytes, especially by the synergistic action with the components of the present invention. By demonstrating the action and maintaining a healthy biological tissue structure, the aging progress is suppressed. Especially in the hippocampus, nerve cells are proliferated and tissues are restored to enhance memory ability and cognitive ability.
It also plays an important role in the immune and reproductive systems. In the immune system, it exhibits the effect of preventing viruses and other infections. In particular, in the reproductive system, female estrogen has a GH secretion-promoting action, but in males in particular, it promotes testosterone release by increasing the cAMP concentration in Leydig cells.
By taking the ingredients of the present invention, enriching the contents of meals, avoiding overeating and continuing exercise, it is certain that the GH action, which is sex steroid dependence, will be strengthened and maintained, and the present invention will be completed. At the same time, the theory of restraining the progress of aging leads to a substantial success.
From the above facts, it is clear that the theory of aging deterrence in the human body is correct.

  “Claim 1” and “Claim 2” In the development of new drugs, results based on animal experiments are mainly used. However, even if they belong to the same mammal, the human living body and the animal living body are fundamentally different, and the result can never be correct. For example, in the case of allergic diseases, the human body generates histamine, SRMA, etc., but in animals it is mainly serotonin. However, human experiments can never be allowed. The present invention was manufactured in-house for a long period of several decades, sold in-house, and as a result of confirming the effect by selling the product alone or in combination with several kinds, the results of HARP-A, or HARP-B, HARP-KK It was established because it was proven that the three principles of non-disease, health and vitality were achieved. It was not a result of a biological experiment but occurred spontaneously.

Background Art on Human Body Remodeling Theory with Stem Cell DNA ES cells (embryonic stem cells) are made from part of blastocysts. Embryos eventually form the whole body, but ES cells are part of the early embryo and retain the universal ability to form all types of cells in the body. Although it has come to the spotlight for the treatment of intractable diseases with ES cells, ES cells retain immune tolerance, but there is a possibility of cancer development specific to growth factors, so research is ongoing There is also a difficult part.
There are about 40 years of experience with stem cells in human bodies. This is evidenced by the fact that tens of thousands of people have recovered after receiving a bone marrow transplant. It was found that it can be regenerated by injecting healthy stem cells into the missing body part. That is, when the bone marrow is damaged due to congenital blood disease, immunodeficiency, or cancer treatment.
Bone marrow contains blood stem cells that produce billions of blood and immune cells every day. These contribute to the soundness of human biological tissues and the enhancement of immunity through blood circulation. Furthermore, mesenchymal hepatocytes are present in the bone marrow and induce differentiation of bone, cartilage, adipose tissue, various muscles, and blood inner wall cells. Tissues that differentiate from bone marrow stem cells are diverse, but all belong to the mesoderm in the early stages of development. Thus, each tissue stem cell is considered to be divided by germ layers. This has significant significance.
The synergistic action of all the components of the present invention achieves rejuvenation and soundness of all tissues of the living body, and in particular, GH directly promotes production of DNA and RNA, and the soundness of the living body centering on the brain lasts for a long time. The goal is to sustain DNA up to 100 years of age by completing the DNA reform spontaneously and further maintaining this healthy state for a long time.

“Claim 4” and “Claim 5” are important matters belonging to the present invention, which are background art relating to enhancement of the intestinal immune mechanism.
It is ultimately T cells that dominate the immune system of the body. Bone marrow governing immune system tissue can revive lymphatic tissue that has become dysfunctional due to radiation or severe illness by inducing differentiation of healthy lymphocytes from bone marrow stem cells It becomes.
However, in the case of cancer development, the balance between the helper T cell and the suppressor T cell is broken, the suppressor T cell action having an immunosuppressive action is enhanced, the antibody producing ability of the B cell is lowered, and the immunity of the cancer-bearing organism is greatly increased. The cancer cells are deprived of the living body.
Furthermore, in autoimmune diseases, the balance of helper T cells and suppressor T cells is reversed, helper T cell action is enhanced, and autoantibody production of B cells becomes possible. Furthermore, T cells that have become autoimmune T cells are activated in their action, produce inflammatory cytokines, and proceed with targeted self-organ destruction. Suppressor T cell action is suppressed, immunosuppression and immune tolerance are reduced, and the function is lost.
The collapse of these bioimmune mechanisms means the occurrence of a crisis state for the human body. It is the intestinal immunity that exists in the small intestine epithelium that should replace the bone marrow and thymic immunity that form the main body of immunity that protects the living body from this state. In the present invention, the purpose of protecting the living body is achieved by strengthening this natural function. Strangely, T cells are produced in the small intestine epithelial tissue, and in the small intestine, the immune regulation is matured and the specific function is exhibited without going through the thymus. Furthermore, NK cells are also activated without going through the thymus, and B cells and macrophages are added to exert cellular immune functions. This series of actions is enhanced and completed by PGE ₁ produced from the component γ-linolenic acid of the present invention by promoting peristaltic movement of the small intestine and promoting blood flow of the small intestinal epithelium. The groundbreaking invention with the highest necessity is disclosed by the above.

[Claim 6] As a background art, Ebers Japan Co., Ltd. has released a plant constipation treatment agent Eveciline (component, 1.125 g of senna fruit, 0.375 g of senna fruit in a daily dose of 1.5 g). Its benefits are (constipation, relief of the following symptoms associated with constipation, headache, hot flashes, rough skin, pimples, loss of appetite, abdominal distension, intestinal abnormal fermentation, sputum)
(Demonstration) The present invention is different in dimension. Defecation is governed by the brainstem. PARP ₁ produced from HARP-A or HARP-B-containing component γ-linolenic acid is synergistic with sodium chondroitin sulfate, thereby cerebral stem arterial vasodilation, blood flow promotion, and capillary blood flow promotion action. With sufficient oxygen supplementation, brainstem function is activated and defecation is performed normally. Furthermore, it is the only substance that shows natural defecation due to the synergistic effect of promoting the intestinal peristalsis by PGE ₁ and the action of jelly-forming water several thousand times that of sodium chondroitin sulfate. The intestines are normalized by taking lactic acid bacteria or butyric acid bacteria. Contributes to the excretion of black stool by promoting intestinal mucosal secretion. In particular, when the elderly said that there was no defecation for 7 days or 10 days, and the effect was small even after taking constipation medicine, it was wondering because this often caused death in a relatively short period of time. Demonstrated to be associated with reduced functionality.
Intestinal cleansing based on improving the function of the brainstem that governs the defecation function by HARP-A or HARP-B is not only to improve the intestinal age of the human body, but also to improve the health of the human body itself. It is an important invention that is unique and unique.

[Claim 7] Regenerative medicine using ES cells is in the limelight as a background technique for the biomodification theory by promoting GH secretion. However, there are many unsolved parts at the present time. Animal studies produce teratomas that contain a complete form of sputum. When ES cells are directly injected into a human body, there is a risk of tumors or sputum in the brain or heart. At present, a method of inducing ES cells to the precursor cell stage is also considered. Furthermore, ES cells are also at risk of being rejected like other transplanted organs. ES cells also have surface protein antigens and are attacked as foreign substances. With respect to regenerative medicine as a future image with various problems, the cell regeneration action by healthy cell differentiation and proliferation by GRH-1 produced in the liver by the GH and GH action in the present invention is the natural nature of the living body. Regardless of the difficult problems of ES cells that have been activated based on their ability, rejuvenation and vitalization of the living body by promoting GH secretion as the current image is HARP-A, HARP-B, HARP -Achieve healthy human body by improving human body tissue, strengthening tissue regeneration, angiogenic action, strengthening bone tissue by increasing bone mass, and strengthening cartilage tissue that supports bone tissue by taking KK continuously.
(Demonstration 1) GH secretion occurs spontaneously by long-term use of HARP-A, HARP-B, or HARP-KK. In the human body, especially in the case of women, the bone mass decreases suddenly between the average age of 45 and 55, which is called menopause, and continues to decrease thereafter. The recovery of normal values by ionized calcium in HARP-KK has been proved by hospital test results by about 100 female living bodies to be surely achieved in one year. Bone mass recovery is fully achieved, but it is not possible to recover from an already bent back and early use is required. Furthermore, it has been proved that cartilage tissue revival is finally achieved, although the period is different, except in cases of extreme degeneration. This effect is achieved by sodium chondroitin sulfate, the main component of pluteoglucan, which is the main component of cartilage tissue, but GH secretion is also relevant.
(Demonstration 2) Although the root of the freshness of the human living body is due to sodium chondroitin sulfate, the appearance of the appearance and morphological transformation phenomenon was surely verified to some extent by promoting GH secretion. I'm really looking forward to years later. In fact, the GH secretion-promoting action is indispensable for reversing the progress of aging and maintaining youthfulness and vitality. It is significant that the phenomenon has been demonstrated more remarkably by the synergistic action with other ingredients. It's deep.
(Demonstration 3) Animals die as soon as the reproductive period ends, and the animal body is destroyed, but the human body is essentially different, and it is possible for women to remain alive even after menopause. is there. In this case, the GH secretion promoting action is a great gospel and means a new start of life. As a result of taking HARP-A, HARP-B, or HARP-KK, the expression of female youth, vitality, and feminine attraction was recognized and demonstrated spontaneously. It is certain that it will manifest significantly over time. In addition, meals are mainly eaten for breakfast and lunch, and dinner is low in blood sugar by restricting the intake of protein and fat and sugar. Exercise is preferably light and continuous, but strengthens to some extent over time. Furthermore, mental stimulation and vitalization are necessary.
As described above, the secretion of GH is highest during the first slow wave sleep during sleep.

[Claim 8] Regarding the background art relating to arteriosclerosis, explanation of the mechanism of action of mevalotin released from Daiichi Sankyo Co., Ltd. (according to manufacturer's data) From HMG-COA to mevalonic acid, which is the rate limiting factor for cholesterol biosynthesis Specifically and competitively inhibit the enzyme HMG-COArcduotase) involved in the biosynthesis of Inhibition of cholesterol synthesis by mevalotin increases the LDL receptor activity because the cholesterol content of hepatocytes decreases, increases LDL uptake from blood into hepatocytes, and decreases the LDL cholesterol level in serum.
Although the mechanism of action is clarified by the above, this mevalotin is an excellent product that can be said to be a child of the times, which has maintained the highest sales for a long time in Japan.
(Demonstration 1) Cholesterol should be a raw material for cells, hormones and bile for the human body and is absolutely necessary. Rather than overdose of foods high in cholesterol content, cholesterol production is regulated in the liver. However, in reality, many people with hypercholesterolemia and hyperlipidemia frequently have cerebral infarction and myocardial infarction, and mevalotin, which has an action mechanism for reducing blood LDL, is essential. .
On the other hand, as a result of requesting 10 users taking HARP-A or HARP-B and checking at a hospital or the like, the total cholesterol level maintained a normal value, and an increase in HDL was confirmed. This action is mainly due to the action of γ-linolenic acid and aged garlic extract.
(Verification 2) Autonomic nerves control blood pressure. As a result, PGE ₁ produced from γ-linolenic acid dominates through the hypothalamus. Since the brain stem is also involved in this control, the arterial vasodilatory action of PGE ₁ produced from γ-linolenic acid is under the control of the brain stem. In any case, the powerful arterial vasodilation effect by PGE ₁ , the blood flow promotion effect by chondroitin sulfate sodium, and the capillary blood flow promotion effect, on the contrary, the brainstem function is strengthened, and the blood flow promotion effect is further ensured. Occurring and normal blood pressure recovery occurred in all people taking HARP-A, HARP-B, and HARP-KK. It was confirmed by direct measurement by 10 people. The decrease in diastolic blood pressure is particularly noticeable, which means an improvement in arteriosclerosis.
(Demonstration 3) HARP-A or HARP-B and further HARP-KK are the only substances having an effect of improving arteriosclerosis. Occurrence of arteriosclerosis is inevitable as a secondary symptom of a diabetic patient, but an electrocardiogram after taking the HARP-B relevant component for about 2 years to a human body that has been in a diabetic state for a fairly long time, Contrary to expectations, no abnormalities were found as a result of CT, echo, and scintin examinations. This fact means that the arteriosclerosis has been improved despite the fact that the development of coronary arteries has been reliably observed due to the occurrence of chest pain and sometimes arrhythmia over the long term. All other symptoms attributed to arteriosclerosis were resolved.

This is background art for “claim 9” and “related to brain function”. Recently, tissue stem cells capable of generating cells that make up living tissue have been found in many tissues and organs such as the skin epidermis, mammary gland, hair follicle, cornea, digestive organs, epithelium, etc. in addition to the hematopoietic system. It is also recognized in nerves. Neural stem cells have the ability to self-replicate and have the pluripotency to create cells such as neurons, atroglia, or orthodentroglio. This fact should make it possible to treat many people.
Furthermore, reports have been made that neural stem cells are discovered from unexpected places in living bodies at unexpected times, or that it is clear that nerve cells have unexpected properties.
As described above, even in adults, it is questioned whether the regenerative capacity of nerve cells is so low in the brain despite the presence of neural stem cells.
The significance of the present invention is particularly significant in view of the fact that one in five people is Alzheimer's recognition after age 85. Even in the mature brain, the reduction of nerve cells is suppressed by taking the ingredients of the present invention and improving the living environment, and as suggested by the background art, the DNA of neural stem cells is reformed to achieve the enhancement of nerve cells. There must be. It is important to create a rich environment that is not material but to pay attention to exercise.
PGE ₁ and IGF- ₁ , which have a strong affinity with the components of the present invention, are closely related to nerve growth factors and neurotransmitters, and both receptors are found in most parts of the brain, especially in the hippocampus. The fact that it exists and the restoration of its neuronal proliferation, memory ability, and cognitive ability has been confirmed by many has significant significance.
Rejuvenation and activation of the brain that governs the human body is what generates rejuvenation activation of the human body, but HARP-A, HARP-B, and HARP-KK are against rejuvenation and activation of the brain. Make a big contribution.
(Demonstration 1) It is the brain stem that has the functions that are absolutely necessary for the living human body to live, and functions such as heart, vascular function, swallowing, sleep, breathing, defecation, and urination are regulated. By continuously taking HARP-A, HARP-B, and HARP-KK, brain stem arterial blood flow increase and capillary blood flow increase occur spontaneously, and the visceral tissue functions under its control Rejuvenation and activation of the entire human body is achieved by strengthening by increasing arterial blood flow and capillary blood flow and further activating the brain stem function by the reverse flow phenomenon. This fact confirms normalization of cardiovascular function, swallowing, sleep, breathing, defecation, and urination in the human body taking HARP-A, HARP-B, and HARP-KK corresponding components for a certain period of time. Has been demonstrated.
(Demonstration 2) According to the data provided by the manufacturer, there was almost no cerebral infarction among chondroitin sulfate sodium users as a result of hospital surveys over the past 5 years, divided into those who did not take chondroitin sulfate and those who did not Things turned out. In fact, more than 10,000 people manufactured and sold products containing sodium chondroitin sulfate, but it was demonstrated that none of the patients with cerebral infarction or myocardial infarction occurred.
It is certain that this fact will become even more prominent for users taking HARP-A, HARP-B, or HARP-KK.
(Demonstration 3) Occurrence of manic depression, a 42-year-old woman, taking four types of antipsychotic drugs continuously in a hospital for 10 years, making defecation difficult, and various constipation drugs prescribed at the hospital are ineffective, dietary fiber Although some stools were being used for products such as those mainly made of, I received a report saying that I took γ-linolenic acid and saw a long stool that would be 1 meter after 10 days. This fact demonstrates that, as a result of long-term use of antipsychotic drugs, brainstem function decline occurred, and γ-linolenic acid enhanced arterial blood flow and capillary blood flow to the brainstem, thereby revitalizing brainstem function. The fact that it took 10 days to see a bowel movement proves that fact even more reliably.

“Claim 10” relates to the necessity of induction of healing in the precancerous stage.
(Background Art) This is a summary of the contents described in a pharmaceutical interview form produced by Diemzar Japan Eli Lilly Co., Ltd., a metabolic antineoplastic agent.
(Pharmacological action)
(1) Mechanism of action of action site The frequency distribution chart when CCR-CEM cells were treated with gemcitabine showed that they accumulated in the initial S phase of the cell cycle. Therefore, gemcitabine is considered to exhibit a specific action on cells in S phase where DNA synthesis is mainly performed.
(2) Activation It is thought that gemstabin is metabolized in cells by deoxycytidine kinase to diphosphates and triphosphates, which are active forms, and directly and indirectly inhibits DNA synthesis.
(3) Inhibition of DNA synthesis It is considered that dFdCTD competes with deoxycytidine triphosphate for DNA polymerase and is incorporated into the DNA strand to inhibit DNA synthesis.
(Serious side effects and early symptoms)
(1) myelosuppression, leukopenia, neutropenia, thrombocytopenia (2) interstitial pneumonia (3) anaphylactoid symptoms such as dyspnea (4) myocardial infarction (5) congestive heart failure (6) pulmonary edema ( 7) Bronchospasm (8) Adult respiratory distress syndrome (9) Renal failure (10) Hemolytic uremic syndrome (survival rate) Diemzar significantly increased survival time 63 cases in the Diemzar group, 63 cases in the 5-FU group Prove by comparing the implementation by. Diemzar 6-month survival rate 46%, 5-FU 31%, 9-month survival rate Diemzar 24%, 5-FU 6%, 1-year survival rate Diemzar 18%, 5-FU 2%.
The above is a summary of the pharmacological effects, serious side effects, and survival rate of Diemzar, a cancer treatment drug by Eli Lilly Japan, which is generally recognized for its superiority, and other anticancer drugs have similar effects. By grasping the substance of cancer treatment in this field, the substance of the background art is suggested.
(Demonstration of necessity and importance of early induction of cancer cure and preventive effect before the medical field in the present invention)
(1) In about 9 years, when the cancer cell population has reached a diameter of 1 centimeter or more, the balance between helper T cells and suppressor T cells is broken, and the immunity of the cancer-bearing organism is greatly increased. Treatment is extremely difficult by methods other than cancer tissue resection.
(2) As demonstrated by Diemzar, anticancer drugs generally have an effect on normal cells of cancer-bearing organisms because inhibition of DNA synthesis of cancer cells is the main mechanism of action.
(3) Diemzar suggests a decrease in leukocytes, especially neutrophils, but other anticancer agents are certainly expected to have an adverse effect on immune cells. Although the above means a decrease in bone marrow function, there is a possibility of inducing a decrease in the function of immune-related tissues including radiotherapy. Causes severe immune function decline.
(4) As described in the serious side effects of Diemzar, there is a possibility of serious side effects that go against treatment in other anticancer drugs, and even in the excellent anticancer drug Diemzar, the one-year survival rate It is only 18% and only 2% for 5-FU.
The above suggests the necessity and importance of generating a healing induction and a preventive effect in the pre-medical stage, that is, in the pre-stage where the abnormal cancer cell population forms a certain size by forming a tissue. This proves that the present invention is epoch-making because the tragedy of cancer treatment caused by being late is so serious.
(Demonstration 1) PGE ₁ produced from γ-linolenic acid increases cyclic AMP of various cancer cells, induces differentiation into normal cells, and suppresses their proliferation. In the human body, in all internal organs and tissues, ATP is produced from budo sugar and oxygen, and PGE ₁ activates adenylate cyclase present in the cell membrane, thereby increasing cyclic AMP. It is possible whenever there is a need. This action normalizes and restores immune stem cells, and induces normal and healthy immune cells to differentiate. When cells divide in the human body, DNA is copied. At this time, an abnormality occurs due to some factor, and cancer cells that are abnormal cells are generated.
In such a case, it is immediately excluded as a foreign substance by normal and healthy immune function, but even if it passes through the eyes of the net, it is induced to normal cells by raising cAMP of cancer cells in the second stage. , Its growth is suppressed. This fact is proved by the fact that there has been no example of cancer occurring in a sustained human living body by taking a component corresponding to HARP-A or HARP-B and further HARP-KK. This fact is even more certain by the fact that you will never suffer from a cold, flu or other infectious diseases.
(Demonstration 2) By taking HARP-A or HARP-B and further HARP-KK, bone mass increase, bone blood flow promotion, tissue regeneration, and tissue function enhancement are achieved for bone marrow tissue as the basis of immunity, Basic enhancement of immunity is established. Furthermore, as demonstrated by the newborn living body, the strengthening of the intestinal immunity mechanism occurring in the small intestinal epithelial tissue is related to the immunity of the human body itself, and it is demonstrated that it leads to the enhancement of the systemic immunity. . This fact prevents cancer development.
(Demonstration 3) Healing induction in the medical field and its predecessor stage should be completely different. However, there may be a situation that is unavoidable.
A 70-year-old man, Sharqli, who did not stop for 2 days, was cured with Chinese medicine, and his family was informed that he had a 3-month survival due to liver cancer. He was not informed that liver cancer had occurred, but was in a state of general exhaustion. Since he was not taking any anticancer drugs or other drugs, he took the corresponding HARP-B component and gradually turned to the best. 2 months Each time they were examined at the hospital and asked to present an examination form, they continued taking for 6 months. As a result, their physical condition returned to a healthy state, and all the examination forms returned to normal values. Because he did not know the fact that he was sentenced to cancer for 3 months, he suddenly stopped taking HARP-B. Although I was advised not to stop taking the medicine three times over the phone, there is no help for it because I don't know that the person has cancer. Because the condition recovery was so complete, I thought that it was probably cancer and left it as it was. About 2 years later, it was found that he died, and it was confirmed that he had liver cancer. When taking the HARP-B corresponding component continuously, it is certainly expected that the healthy state is maintained even now.
(Demonstration 4) 75-year-old woman, pancreatic cancer, 3 months advance notice of hospital survival, rash occurred in Diemzar, 5-FU chemicals used, healthy for 6 months while taking the same drugs and HARP-B The state was maintained. After that, resistance to 5-FU chemicals also developed, and the medical condition gradually worsened and food intake became impossible. Of course, the corresponding HARP-B component was also discontinued. However, although the hospital survival notice was three months, I was able to survive for more than one year.
When judging from the fact that the 5-FU 1-year survival rate based on the interview form provided by Eli Lilly Japan is only 2%, the significance of HARP-B is confirmed and the existence value of HARP-B is demonstrated.

As background technology related to "Claim 11" and "Claim 12", the documents provided by Shionogi Pharmaceutical Co., Ltd. are summarized and described for glucocorticoids secreted from the adrenal cortex. Physiological actions of glucocorticoids (1) Promotion of glycogen production and gluconeogenesis in the liver, promotion of lipolysis and increase of protein degradation in adipose tissue and muscle. Suppresses sugar intake in most tissues except the liver, heart, and brain. As a result, blood free fatty acid and budo sugar levels increase.
(2) Anti-inflammatory and anti-allergic effects include increased capillary permeability due to inflammation, migration of migrating cells, inhibition of accumulation, blocking of antigen-antibody reaction, suppression of cytotoxic activity, suppression of release of chemical substances from the cell chamber .
(3) It has a lymphocyte and eosinophil reducing action, atrophy of the lymphoid tissue to reduce the number of lymphocytes, a decrease in eosinophilic leukocyte, and an erythropoiesis action in the bone marrow.
(4) Shows androgenic action.
(5) Increases excitability of the central nervous system, enhances mood, or presents with depressive symptoms.
Serious side effects [1] Induction and exacerbation [2] Pathologic osteotomy (osteoporosis) [3] Adrenal atrophy [4] Peptic ulcer [5] Diabetes onset and exacerbation [6] Psychiatric and neurological symptoms [7] Thrombus formation [8] Growth disorder [9] Edema, hypertension, heart failure [10] Wound healing disorder [11] Muscle atrophy, myobate.
The above describes the physiological effects and serious side effects of the adrenocortical hormone glucocorticoid. This glucocorticoid is an important substance that is immediately secreted and exerts an action that should protect the life of the human body when a strong shock state such as anaphylactic shock occurs in the human body. Adrenal cortex function should not be reduced by easy and continuous use. Therefore, it cannot be used generally, but in the medical field, this glucocorticoid prevents the increase of vascular permeability due to inflammation and is a symptomatic treatment for autoimmune diseases that are intractable diseases. Nevertheless, it is the only substance that has a dramatic effect and must be used. In contrast to this background art, HARP-A, HARP-B, and HARP-KK are the only substances that maintain defense against foreign substances and exert anti-inflammatory effects, and are in the pre-medical stage for autoimmune diseases. Healing induction and preventive effect are important. Furthermore, it is surprising that all the serious side effects of glucocorticoids are reversed and significantly act on the living body.
(1) The defense power against infectious diseases is outstanding. (2) With regard to osteoporosis, the normal bone mass recovery can be achieved in one year. (3) Strengthen adrenal cortex function through the hypothalamus. (4) Gastric mucosa protection by inhibiting gastric secretion and producing mucous secretion glycoprotein. (5) As an extra-adrenocortical action of ACTH, cyclic AMP is increased and insulin secretion is promoted, but as a sure action, the occurrence of secondary symptoms of diabetes is suppressed. (6) Budosugar and oxygen are sufficiently supplemented by cerebral arterial blood flow promotion and capillary blood flow promotion action, which significantly improves mental and neurological symptoms. (7) Strengthen arterial blood flow to prevent thrombus formation. (8) Have strong affinity with GH and promote its secretion. (9) Strengthen renal function and increase urine volume by promoting renal artery blood flow and capillary blood flow. Furthermore, it promotes arterial blood flow and capillary blood flow for all visceral tissues of the living body, and normalizes blood pressure.
As for heart failure, coronary artery blood flow promotion and accessory blood flow promotion significantly improve the function.
(10) Inhibition of increased vascular permeability to prevent leukocyte extravasation, and further enhancement of wound regeneration by promoting tissue regeneration and repair (11) Enhanced GH secretion enhances protein production and significantly improves muscle atrophy Works.
As described above, not only does it reverse the serious side effects of glucocorticoids, but also HARP-A, or HARP-B, HARP-KK itself inhibits the increase in vascular permeability and prevents the inflammatory action. In particular, the necessity and importance of belonging to the preventive field that induces autoimmune disease to a curative state or prevents its occurrence in the pre-treatment stage in the medical field where glucocorticoids must be used It is invention which has.
(Demonstration 1) If streptococcus or other virus infections are related to abnormalities in bone marrow tissue or abnormalities in immune cells generated from immune stem cells, it is ensured by taking HARP-A, HARP-B, or HARP-KK. To be prevented. The fact is proved by the fact that there are no cases of cold, influenza, or other infectious diseases among those taking the above ingredients.
(Demonstration 2) By taking HARP-A, HARP-B, or HARP-KK, bone mass increase, bone blood flow promotion, bone marrow tissue regeneration, and strengthening, normalization and normalization of bone marrow function is achieved. Adenylyl cyclase present in the cell membrane is activated, and by enhancing cyclic AMP, normalization and restoration of bone marrow immune stem cells and normalization and restoration of differentiation-induced lymphocytes are achieved. Normalization and soundness of functions are achieved. This fact is proved by the fact that no autoimmune disease or similar disease has occurred in the user taking the relevant ingredient.
(Demonstration 3) The enhancement of intestinal immunity by the above components is related to the immune mechanism of the human body, which is proved by the enhancement of immunity of the neonatal body by γ-linolenic acid contained in breast milk. When antigen-sensitized in the mechanism, T-cells and IgA plasma cells are generated by 70-80% of the whole organism, and this function is proved to be powerful.

Background Art on "Aging Progress Suppression Theory" Since regenerative medicine using ES cells has been in the limelight and its research has progressed, various things have been revealed. For example, unlike skin and liver organs, nerve tissues such as the brain and bone marrow are not repaired naturally, and no repair action actually occurs despite the presence of nerve cells in the nerve tissue. Since this fact has been questioned, it is certain that it will eventually be elucidated. In the present invention, the relationship of glial tissue is suggested.
Furthermore, it was confirmed that GH and IGF-1 do not exhibit the same function but perform different functions independently. In addition, γ-linolenic acid and PGE ₁ are different, and PGE ₁ is produced as necessary, and the mechanism of action may be different.
(Demonstration 1) “Establish morphological health” Bone mass recovers to normal value in 1 year, cartilage mass is normalized within a certain period except in special cases, and muscle synthesis is also promoted by GH secretion to normal protein synthesis This is proved by the appearance of people who walked in a refreshing manner due to the achievement of aging.
(Demonstration 2) “Establishment of healthy biological function” Promotes arterial blood flow and capillary blood flow to the brainstem, and the brainstem function is activated and revived by sufficient supplementation of budoo sugar and oxygen. It is proved that the progress of aging of the human body is suppressed by achieving normalization of vascular function, swallowing, sleep, breathing, defecation and urination.
(Demonstration 3) “Normalization and soundening of living organ tissues” Synergistic activation of brain stem function promotes arterial blood flow and capillary blood flow to the internal organs and tissues of the whole body. Tissue regeneration and resurrection effects are exerted, especially due to each visceral tissue stem cell DNA reform, normal and healthy cells are induced to differentiate, normal and healthy viscera and tissues are formed, and it is possible to maintain a healthy state Proven.
(Demonstration 4) “Normalization of normal immunity and establishment of healthy” Bone blood flow promotion, bone marrow tissue regeneration, resurrection, immune stem cell DNA reform induces normal healthy lymphocytes to differentiate and normalize immune functions And soundness are established. Furthermore, immune immunity is generated by strengthening intestinal immunity function, which means that there is residual health. Demonstrated by never having a cold, flu, or other infection.
(Demonstration 5) “Life-supporting cancer, early cure induction and establishment of preventive ability in the previous stage of medical treatment for cerebrocardiovascular disorders” Increase cyclic AMP of various cancer cells within a certain period of time To induce differentiation into normal cells and suppress their proliferation. Furthermore, normalization of immune immunity by (demonstration 4), establishment of soundening, and establishment of immune immunity establish cancer cure induction and preventive effects. Furthermore, it prevents the occurrence of vascular disorders such as cerebral infarction by improving arteriosclerosis, strengthening vascular wall tissue, maintaining normal blood pressure, and further promoting arterial blood flow and capillary blood flow. Brain stem function restoration is related to cardiac function activation, and coronary artery and capillary blood flow promoting action prevents myocardial infarction from occurring, and at the same time, blood clots generated due to cardiac dysfunction are sent to the brain Preventing cerebral infarction. It has been proved that chondroitin sulfate alone does not cause the occurrence of cerebral infarction in the past 5 years. However, including the demonstration 4, such symptoms have occurred in the prevention of cancer and the prevention of brain and cardiovascular disorders. This is demonstrated by the lack of examples.

An object of the present invention is to maintain a healthy and vigorous state of a human body without suffering from various diseases, and to maintain it until the age of 100.
Issues corresponding to "Claim 1" and "Claim 2".

The viscera and tissues that should be kept healthy have lameness in their functions, and any of them can cause diseases. With the aging of the population, the number of occurrences of pathological abnormalities increases, and the number of therapeutic drugs administered in the medical field also increases. Furthermore, depending on the medical condition, the need for long-term administration also arises.
However, even if an excellent drug is chemical, it is a foreign substance for the human body, so it naturally becomes a burden on the function of metabolism and excretion. Since it is a chemical substance in particular, it exerts its healing power against lesions, but on the other hand, it has a negative effect on stem cell DNA reform to form a healthy tissue. This is particularly noticeable in anti-neurologic drugs. It is an important issue that needs to be resolved.
Although the present invention that should achieve the soundness of human tissue by stem cell DNA reform is epoch-making, there is also a fatal reform retrograde factor. For example, since all anticancer agents are DNA inhibitors of cancer cells, they have a significant effect on tissue stem cell DNA and go against reform. Furthermore, the glucocorticoid, which is an adrenal cortex hormone that exerts the most important therapeutic effect on autoimmune diseases, becomes a destructive factor for the healthy biological tissue mechanism by stem cell DNA reform. This is an important issue for the present invention. A problem corresponding to "Claim 3".

An important subject of the present invention for maintaining the homeostasis of the human living body and achieving the three principles of non-disease, health and vitality is the enhancement of immunity to protect the living body from foreign substances such as viruses and bacteria. However, thymic atrophy occurs as the population ages, and the number of T cells with specific functions that play a central role in immunity is reduced to 10% of the peak level. The incidence of immune disease is also increased. Currently, in the medical field, there is no way but to concentrate on treatment, and it is difficult.
The solution according to the invention is the most important matter. Issues corresponding to "Claim 4" and "Claim 5".

Human tissue regenerative medicine using ES cells has been in the spotlight and its research is progressing. However, the present invention is the origin of unnatural human tissue repair and tissue regenerative medicine due to such external factors. In the present invention, the present invention protects the human living body from various diseases by activating the excellent functions originally possessed by the human living body through tissue repair, tissue regeneration, etc. The challenge is to achieve vigorous organization formation and maintenance of its functional capabilities.
A problem corresponding to "claim 7".

The greatest difficulty in achieving the three principles of non-disease, health and vitality in the human body is the occurrence of cerebral infarction and myocardial infarction. The cause is arteriosclerosis, and the use of cholesterol, a drug that lowers the LDL level, is highly significant, but it does not go beyond the preventive effect. Symptomatic drugs are continuously administered to people with hypertension, but they have not reached the level of complete improvement of arteriosclerosis reform. In addition, as a therapeutic agent for the occurrence of cerebral infarction, aspirin-based drugs are mainly used and are most effective, but there is a possibility of inducing cerebral hemorrhage as a characteristic of the infarction therapeutic agent. Although various medical conditions are associated with heart disease, therapeutic agents are mainly symptomatic treatments as represented by nitroglycerin.
As described above, healing induction and preventive effects are necessary in the pre-treatment stage in the medical field, and improvement of arteriosclerosis is an important issue. A problem corresponding to "claim 8".

  Rejuvenation and activation of brain functions leads to rejuvenation and activation of the human body. The functions of the internal organs and tissues of the living body are under the control of the brain. In particular, the functions necessary to maintain life are under the control of the brain stem. Therefore, in order to achieve the three principles of the non-disease, health and vitality of the human living body of the present invention, it is essential to improve the function and function of the brain, particularly the brain stem. This is a different dimension from the medical field and is the most important issue in the present invention. A problem corresponding to "claim 9".

Regarding the occurrence of cancer, the site of occurrence, the properties of cancer cells, and the like are various, and early detection is extremely difficult in the medical field. It is said that the possibility of detecting Milli cancer is 1 / 2,000, and it is said that it takes about 9 years for the cancer cells to reach 1 centimeter in diameter. May hold and belong to the Cancer Reserve. On the other hand, even if early detection of cancer occurs, if it occurs in a place where it cannot be excised, it is mainly treated with an anticancer agent. As you can see, its survival rate is too low. Therefore, the discovery of cancer generally means the death sentence.
As described above, induction of long-term healing in the previous stage of the medical technology field, and further exerting a preventive effect on generation become a major issue with necessity and importance. A problem corresponding to "claim 10".

  The incidence of type I allergy has been increasing due to recent dietary habits and environmental changes. In general, taking drugs that are mainly antihistamines has surpassed the situation, and it does not solve the fundamental factors. There are serious constitutional factors such as a decrease in immunity at the root of the phenomenon in which inflammation must be generated or must be generated in the human body. Based on this fact, an important problem that the present invention has to solve arises. In addition, the incidence of autoimmune diseases increases with the aging of the population, but the occurrence of autoimmune diseases is due to the failure of the biological immune mechanism, so if the immune mechanism is almost destroyed Since this means the destruction of the human body, an important and serious problem occurs in the present invention. Issues corresponding to "claim 11" and "claim 12".

  The aging phenomenon due to aging progresses spontaneously, and if left as it is, the three principles of non-disease, health and vitality are gradually lost, and it is difficult to maintain and the purpose of maintaining up to 100 years old is It becomes impossible. The challenge of the aging deterrence theory is to prevent aging within the possible range of each claim. A problem corresponding to "claim 13".

Means to solve the problem

  [Claim 1] [Claim 2] In the present invention, by taking HARP-A, HARP-B, and further HARP-KK, by taking a balanced diet and continuing moderate exercise, The challenge of achieving the three principles of illness, health, and vitality and maintaining it until the age of 100 is solved, but for that purpose, all the issues from "Claim 3" to "Claim 13" are covered. It is necessary to do. The present invention has already solved that problem.

[Claim 3] The origin of the present invention is based on the fact that the user of HARP-A or HARP-B is aware that the youth does not change forever. Furthermore, there are different stem cells in various internal organs and tissues, and if a DNA reform of the stem cells is established, it is always possible to induce differentiation of healthy youthful cells and form a healthy living tissue structure. found. When this DNA reform is established, it is possible for the human body to maintain a youthful and healthy tissue structure, and the phenomenon of maintaining youthfulness without the occurrence of tissue degradation indefinitely appears. This fact indicates that in human organs and tissues, ATP is produced by oxygen and budose sugar, and this ATP activates adenylate cyclase present in the cell membrane by HARP-A or HARP-B-containing components. This is the result of producing cAMP and enhancing the action of GH and IGF-1 and exerting the function of inducing normal healthy cell development.
Furthermore, this effect is further ensured by supplementation of nucleic acids with HARP-KK-containing components. The present invention has been established through decades of research, experience, and achievements, and cannot be seen anywhere else.
In the medical field, most of the drugs used for treatment are chemical substances, especially anticancer drugs and corticosteroids, which have a serious adverse effect on DNA and have been shown to go against stem cell DNA reform. In reality, HARP-A, HARP-B, and HARP-KK, including other claimed inventions, induce healing and prevention in the previous stage of the medical field. It has been confirmed that it exerts its effects. The problem with this fact is reliably solved and only the significance of the present invention is disclosed.

“Claim 4” and “Claim 5” The intestinal immunity mechanism is essential for human defense. Γ-Linolenic acid contained in breast milk to protect the living body of a newborn born in a state where there is almost no defense against foreign substances is not only strengthening the intestinal immune system, The relationship between the intestinal immune system and the systemic immune system was confirmed as evidenced by the need for enhancement. Based on decades of research, experience, and achievements, obtain evidence that HARP-A, HARP-B, and HARP-KK users will never catch a cold and will never suffer from an infection such as influenza. Became possible.
This fact has occurred even in the elderly, and it is even more reliably established that there is a link between strengthening the intestinal immunity and systemic immunity. Since thymus atrophy occurs and the amount of T cells, which is the basis of human biological immune function, has decreased to 10% of the peak, the decrease in immune function is clearly manifested. Under these circumstances, taking HARP-A, HARP-B, or HARP-KK strengthens the intestinal immunity and means that more and more T cells are generated from the small intestinal epithelium. It is a great gospel, and the strengthening of immunity in the elderly is definitely proven. As described above, means for solving this problem is established, and further, this fact proves that the present invention is an epoch-making invention. At the same time, it becomes possible to achieve the three principles of non-disease, health, and vitality by HARP-A, HARP-B, and HARP-KK.

[Claim 7] Human body regenerative medicine using ES cells has complex elements ahead, and there are unreasonable parts to solve. Naturally complex elements have been solved for tissue repair and tissue regeneration by liver-derived IGF-1 produced by GH and GH action produced by the human body to maintain self-health . A means for solving the problems in the present invention is to exhibit a series of anabolic actions centering on the promotion of GH secretion by HARP-A, HARP-B, and HARP-KK.
In particular, GH exerts the promotion of protein synthesis and the synthesis of DNA and RNA. This claim demonstrates a strong synergistic effect on the rejuvenation and vitalization of biological tissue structure by "Claim 3" stem cell DNA reform. To do. Furthermore, “Claim 9” not only exhibits a strong synergistic effect on brain function, particularly the achievement of rejuvenation and activation of human biological tissue by rejuvenation and activation of the brain stem, but also a fatal neuron for human living body relative reduction, synergy but in the present invention have confirmed the effect of aging garlic extract and vitamin B ₆ and GH is excellent.
Animals lose their life when the reproductive phase ends. In the human body, it is impossible for a woman to reach menopause. As a great gospel of women, a series of assimilation actions centered on GH according to the present invention means the start of a new life for women. It is recognized that this effect restores the youthfulness, attractiveness, and vitality of women, and is thought to be caused by the bone end action of GH, but facial changes are observed in some people, facial acupressure, facial massage, etc. A beautiful face method is possible.
With the above description, the important first problem in the “claim 7” of the present invention is solved. As one of the factors for promoting GH secretion, it is necessary to maintain normal blood sugar at the time of going to bed at night, but the problem is solved by the recent increase in diabetes and the decrease in insulin action due to aging. Means are needed. Regarding this, taking HARP-A or HARP-B leads to normalization of blood glucose level by light continuous exercise, accompanied by the promotion of sugar oxidation by sulfur-containing amino acids contained in aged garlic extract. It is possible to maintain, and this problem is solved.
As described above, the first and second problems are solved, and it is demonstrated that the present invention is epoch-making, and at the same time, the non-disease, health and vitality targeted by the present invention are surely achieved. .

[Claim 8] The present invention belongs to an advanced technical field that exerts a healing induction and a preventive action in the previous stage of medical treatment. Since the brain and cardiovascular disorders are diseases that occupy the highest mortality rate, the problem of the present invention is to exhibit an arteriosclerosis improving function as a result. Means for solving this serious problem are as follows. The present invention eliminates animal experiments of different dimensions, and has been established by decades of long-term research, experience, and results (demonstration).
As a result of investigations over the past 5 years by taking HARP-A, HARP-B, containing component sodium chondroitin sulfate alone or in combination with other components, it has been proved that there is no occurrence of cerebral infarction or myocardial infarction. Furthermore, when taking γ-linolenic acid and aged garlic extract in combination, the cholesterol level is maintained at a normal level, and it is confirmed by hospital test sheets requested by many people that it exhibits the action of raising HDL, particularly good cholesterol. It was. In the medical field, mevalotin's action to reduce LDL acts to prevent arteriosclerosis, while HDL-increasing action acts to improve arteriosclerosis. The most powerful action for improving arteriosclerosis is the effect of PGE ₁ generated from γ-linolenic acid and chondroitin sulfate sodium on strong arterial vasodilation, blood flow promoting action, platelet aggregation inhibiting action, and erythrocyte variability promoting action. It is an action that promotes flow. This fact not only exhibits a strong effect of improving arteriosclerosis, but also exhibits an infarction suppression effect.
Anti-lipid peroxidation by anti-oxidation effect by aging garlic extract exerts an arteriosclerosis-improving action, but it exerts a great effect especially when accompanied by exercise therapy.
Although chondroitin sulfate sodium and vitamin B ₆ exert their functions in strengthening the blood vessel wall, "Claim 7" achieves rejuvenation and restoration of the blood vessel tissue by promoting protein synthesis and promoting lipolysis by promoting GH secretion. . Furthermore, by strengthening the brain stem function that governs the vascular function, the function enhancement and soundness of the entire vascular tissue are achieved, and the arteriosclerosis improving action becomes perfect. [Claim 3] According to the DNA reform of tissue stem cells, healthy cells are induced to differentiate, a healthy vascular tissue structure is formed, and a healthy vascular function is maintained for a long time.
As described above, the important problem corresponding to “claim 8” is solved, and at the same time, achievement of the three principles of non-disease, health, and vitality by HARP-A, HARP-B, and HARP-KK is established.

[Claim 9] A decrease in brain function that dominates the human living body causes a significant decrease in function and degeneration of the human living body. In particular, when brain stem failure occurs, a devastating blow is given to the human body.
Although it is said that the number of nerve cells is reduced by 100,000 each day, the decrease in brain stem function and the decrease in nerve cells occur spontaneously.
In accordance with the above facts, the important problem of the present invention is to function the brain, in particular, the brain stem function to be healthy and activated, and to suppress the neuronal cell depletion. Based on research, experience, and achievements (demonstration) over several decades, the solutions to the above problems are shown as follows.
(1) PGE ₁ produced from γ-linolenic acid, arterial vasodilation by sodium chondroitin sulfate, arterial blood flow promoting action, capillary blood flow promoting action by improving erythrocyte change brain, and infarct generation inhibiting action, and 20% of living body The brain, especially the brainstem function, is activated by sufficient supplementation of consuming budo sugar and oxygen. Furthermore, the brain stem function is further enhanced by the backflow phenomenon due to the enhancement of the arterial blood flow and capillary blood flow promoting action of all internal organs and tissues of the living body. This is because the activated brainstem function enhances the arterial blood flow and capillary blood flow promotion function for the blood vessels under its control, thereby further strengthening the arterial blood flow and capillary blood flow to the brainstem, Proven by demonstrating full functionality.
(2) Reduction of infarct size and prevention of infarction are due to the effect of promoting arterial blood flow and capillary blood flow, but cerebral infarction and myocardial infarction inhibition are demonstrated by chondroitin sulfate sodium salt as demonstrated by the survey over the past five years. This is due to the specific function of. The vascular wall strengthening action is also due to the function centered on sodium chondroitin sulfate, but the repair and regenerative action against vascular wall degeneration, breakage, etc. are all HARP-A, HARP-B, HARP-KK centering on GH action This is due to the synergistic action of these components.
(3) For the construction of a healthy, vigorous tissue structure of the brain, particularly the brain stem, “Claim 7” HARP-A or HARP-B centered on GH secretion promoting action, and further HARP-KK, all components It is achieved by the synergistic action. Further, healthy and vital cells are differentiated and induced by DNA reform of the brain, particularly brain stem tissue stem cells according to claim 3, and the healthy and vital brain, particularly the brain stem tissue structure is constructed and maintained.
(4) In the human body, it is said that the number of nerve cells decreases by 100,000 per day. It is said that if you drink a large amount of liquor, you may lose 1 million per day. Forgetfulness is especially severe when you are nearly 80 years old. This decrease in nerve cells occurs spontaneously and is left unattended by anyone. As a result of investigating vitamin B ₆ involved in protein synthesis and aged garlic extract having antioxidant power, a considerable disparity was recognized. A significant discovery was hidden in the present invention. [Claim 7] Investigation of rejuvenation and vitalization of the living body by synergistic action with other components centering on GH secretion in 10 people, and forgetfulness has hardly occurred in 3 elderly people among them Was recognized.
This fact demonstrates that there is a strong inhibitory effect on neuronal cell loss due to the synergistic action of GH secretion promoting action and HARP-A, or HARP-B, HARP-KK-containing component vitamin B ₆ and aged garlic extract.
Thus, the important problem of the present invention corresponding to “claim 8” is solved. Furthermore, it is demonstrated that the present invention is epoch-making, and the three principles of non-disease, health, and vitality can be achieved by HARP-A, HARP-B, and HARP-KK.

  “Claim 6” The solution to the problem relating to normalization of the intestines and the normalization of defecation is that the defecation is under the control of the brainstem, so that “claim 9” means activation of brain stem function As will become apparent from the explanations regarding the above, the activation of the brain stem function achieves a healthy intestinal tissue and regulates the defecation function. Feces accumulated in the intestinal folds are also discharged and the intestinal age rejuvenates. This makes an important contribution to the achievement of the three principles of non-disease, health and vitality of the body by HARP-A, HARP-B, and HARP-KK.

“Claim 10” In the field of medicine, it is steadily progressing and is in great development, but regarding cancer treatment, the excellent anticancer drug Gemzar has a one-year survival rate of 8% and 5-FU2% too much. In addition, a decrease in immunity due to a decrease in white blood cells and neutrophils due to a decrease in bone marrow function, and the treatment thereof is extremely difficult.
In view of the current situation, the most important problem to be solved by the present invention is to induce early healing and preventive effects in the previous stage of the medical field, and the means to be solved are It is essential.
The present invention has been established through several decades of research, experience and achievements (demonstration). Meanwhile, HARP-A, HARP-B, and HARP-KK users are never affected by colds and never suffer from infections such as influenza. There is no one who has cancer.
(1) “Claim 3” Normal and healthy cells are induced to differentiate by DNA reform of human living stem cells, and abnormal cells such as cancer cells cannot be generated. This is even more certain by the nucleic acid supplementation in HARP-KK. Even if the administration of HARP-A, HARP-B, or HARP-KK is delayed, PGE1 produced from γ-linolenic acid increases cAMP of various cancer cells and differentiates into normal cells. Induces and suppresses the growth of cancer cells.
(2) Bone marrow, thymic immune system enhancement, bone blood flow promotion, bone marrow tissue regeneration enhancement action, and immune stem cell DNA reform, induced differentiation of healthy progenitor T cells, B cells, NK cells, Aged in the thymus. T cells are generated and matured by strengthening the intestinal immunity mechanism in the small intestinal epithelial tissue and enhancing the peristaltic mucosal blood flow of the small intestine.
As described above, both immune mechanisms centering on T cells are strengthened, and cancer cells are eliminated mainly by cellular immunity.
(3) About 20 years ago, on a newspaper, a group of people who drink milk every day and a group who does not drink milk were divided into two groups. However, since milk is the best absorbed source of calcium, it is thought that it is a problem whether or not to get cancer depending on whether or not calcium is consumed. Therefore, it is recognized that ionized calcium in HARP-KK is particularly relevant to strengthening immunity and has a preventive effect on cancer development. Furthermore, it was confirmed by the manufacturer-provided documents that aging garlic extract also has an immunity enhancing effect. As described above, the enhancement of immunity is due to the synergistic action of the components containing HARP-A, HARP-B, and HARP-KK.
In the medical stage, the cancer is often about 1 centimeter in diameter, the immunity of the human body is greatly reduced, and the anti-cancer drugs used are normal cell DNA production inhibition, immune tissue, Since it adversely affects immune cells, immunity is further reduced and treatment is extremely difficult.
However, healing induction and preventive action in the previous stage of medical care to which the present invention belongs can be reliably achieved by many years of research, experience, and results (demonstration). Obtaining a passport that should prevent cancer development by taking HARP-A, HARP-B, and HARP-KK continuously means that you have earned the greatest wealth.
As described above, means for solving important problems are established, and it is proved that the present invention is epoch-making. In addition, the three principles of non-disease, health, and vitality can be achieved by HARP-A, HARP-B, and HARP-KK.

[Claim 11] [Claim 12] The allergic phenomenon to a new antigen is completely prevented by taking HARP-A or HARP-B and further HARP-KK. However, the allergic phenomenon to the antigen that has already occurred cannot be prevented, but it exerts a mild deterrent action. PGE ₁ produced from γ-linolenic acid moderately suppresses allergic phenomena by activating adenylyl cyclase present in the cell membrane, enhancing cAMP and preventing the release of histamine and SRM-A from the cell chamber. Demonstrate the effect. This action is different from the antihistamines currently in common use. Although there are various autoimmune diseases called intractable diseases, the symptoms are more severe than the type 1 allergy phenomenon, and there may be cases in which symptoms causing a fatal blow to the human body may occur. Corticosteroids and glucocorticoids that are currently used in the medical field are highly effective, but are symptomatic and not fundamental. The original function of glucocorticoids is secreted immediately when a shock or the like occurs in a human body, and the original action is to eliminate sudden symptoms and save lives. However, there is a possibility that sudden death may be caused by taking a glucocorticoid for a long period of time and stopping it suddenly. Even for the treatment of autoimmune diseases in accordance with specialized knowledge, a decrease in adrenal cortex function is inevitable.
However, it would be even more difficult if no glucocorticoid product was present. This is because there are no other products that are effective against autoimmune diseases other than glucocorticoids.
The common feature of glucocorticoids and HARP-A, or HARP-B, HARP-KK is anti-inflammatory action, and there are differences in the mechanism of action and strength of action, but both are significant for autoimmune diseases. Act on. However, glucocorticoids have many serious side effects as described below. In contrast to this fact, the components of the present invention go against all the serious side effects and all of them exert a beneficial action on the human body.
The facts are described below.
Serious side effects of glucocorticoids (1) Promotes liver glycogenogenesis and gluconeogenesis, suppresses intake of sugars other than liver, heart, and brain, raises blood budo sugar level, and causes diabetes-like symptoms .
(2) In order to promote protein degradation, the degeneration tendency of visceral tissues of the living body is expressed, and the function of the organ in which supplementation of budo sugar is suppressed occurs. Occurrence of edema (circular face) is high due to gastric ulcer due to promotion of protein catabolism and secretion of renal sodium. Increases the amount of free fatty acids in the blood by promoting lipolysis and observes the occurrence of blood hypermaemia.
(3) Lymphoid tissue is atrophy, lymphocytes and acid leukocytes are decreased, infection is induced by immunity reduction, and hatred.
(4) Reduce bone mass (osteoporosis) and induce pathological fractures.
(5) Adrenal atrophy occurs due to long-term use of glucocorticoid preparations, and secretion becomes impossible when a shock or the like is required.
(6) Demonstrate androgenic action.
(7) Demonstrate thrombus generation.
(8) Muscle atrophy occurs due to protein catabolism.
(9) Wound healing disorder occurs.
(10) Causes edema and hypertension.
(11) It has the action of going against growth factors.
HARP-A, or HARP-B, HARP-KK completely suppresses serious side effects of glucocorticoids.
(1) For diabetes, induction of natural healing and complete prevention of secondary symptoms by combined use of exercise therapy.
(2) Rejuvenation and vitalization of all visceral tissues can be achieved by sufficiently supplementing budo sugar and oxygen by promoting the synthesis of protein, the arterial blood flow, and the venous blood flow by the action mainly of GH secretion. Of course, gastric ulcer healing effect, renal function soundness, hyperlipidemia improving effect is exhibited.
(3) Strengthening of bone marrow, thymic immune system, and intestinal immune system has been established, and it has excellent defense against infectious diseases.
(4) Due to the ionized calcium in HARP-KK, the bone mass maintains a normal value of 100%, and there is no fracture.
(5) Contributes to sound adrenal function through the hypothalamus.
(6) Has strong relaxation properties with all steroids and exhibits harmonious action.
(7) Reduces thrombus size and exerts cerebral infarction and myocardial infarction generation inhibiting action.
(8) The muscle tissue is strengthened by the protein synthesis promoting action, the arterial blood flow and the capillary blood flow promoting action on the muscle tissue.
(9) It suppresses the increase in blood vessel permeability, prevents leukocyte migration, and exerts a powerful defense force against bacteria, thereby exerting a tremendous early healing power.
(10) Due to promotion of renal blood flow, renal function remains normal and edema cannot occur. Furthermore, the blood pressure is maintained at a normal value, which promotes arterial blood flow and capillary blood flow in all human tissues. Furthermore, normalization of diastolic blood pressure is particularly pronounced.
(11) Rejuvenation and vitalization of the human body are achieved through a series of actions centered on the GH secretion promoting action.
As described above, it was proved that serious side effects of glucocorticoid and HARP-A, HARP-B, and HARP-KK reverse all the parts other than the anti-inflammatory action and significantly act on the human body. .
Generally speaking, there are many types of autoimmune diseases, which differ depending on the severity of symptoms, but are said to be intractable. There are subtleties in the medical field, but there are other symptomatics besides this glucocorticoid. There are no other drugs that are effective even in therapy. Therefore, even if there are serious side effects, this medicine must be used for treatment. In some cases, this medicine must be taken for a long time. Although autoimmune diseases themselves can be life-threatening, this drug also causes atrophy of the adrenal cortex due to long-term use, and life is because glucocorticoids are not secreted as needed when intense stress occurs A crisis occurs. In this way, we see the occurrence of a second risk factor next to the first risk factor of autoimmune disease.
The present invention solves the problem and discloses an epoch-making invention relating to an autoimmune disease.
{Circle around (1)} Macrophages secrete a large amount of PGE ₁ PGE ₂ to increase the level of T cells in order to suppress immune excess of T cells. When the need for T cell attack occurs due to an immune response, the level of PGE ₁ PGE ₂ is decreased to enhance T cell function. In autoimmune diseases, the self-reactive T cell function is enhanced to secrete inflammatory cytokines and promote the destruction of the target self tissue. Therefore, more PGE ₁ is used than the component γ-linolenic acid of the present invention. It is self-evident to suppress the enhancement of self-reactive T cells by producing them.
(2) Prior to the onset of autoimmune disease, virus infections such as streptococci and retroviruses are considered to be triggered. To prevent this, bone marrow function enhancement by the present invention component was established. Bone marrow thymus immune system and intestinal immune system have been strengthened.
Therefore, it exerts a powerful preventive action against virus infection.
As described above, the present invention has established a preventive function and an early healing induction function against autoimmune diseases.
There has been no one who has developed an autoimmune disease among those taking HARP-A, HARP-B, or HARP-KK for a long time. Even in the elderly, it has been confirmed that they are not infected with colds, influenza, and other infectious diseases. This is not only the establishment of a healthy bone marrow thymus immune system, which is the mainstream of immunity, but also the intestinal immune mechanism, which is a reserve. It is a serious and significant phenomenon that more T cells are produced than small intestinal epithelial tissue, and immune tolerance, immune response regulation, and ripening in small intestinal epithelial tissue without going through the thymus. is there. This is because when a failure occurs in the bone marrow thymus immune system, the destruction of this immune mechanism means the destruction of the human body itself. It is possible to maintain
Glucocorticoids and HARP-A, or HARP-B and HARP-KK are not comparable in terms of the strength and weakness of their anti-inflammatory function, but conversely, against the fatal side effects, On the other hand, there is a large disparity in that it works significantly. As described above, the healing induction in the previous stage of the medical treatment of the present invention is only moderate deterrence, but since the preventive effect is certain, the means for solving the problem to be solved of the present invention is as follows. It is established and further proved to be unparalleled in the necessity and importance of the present invention. In addition, HARP-A, HARP-B, and HARP-KK will surely achieve the three principles of non-disease, health and vitality for the human body.

[Claim 13] In the human body, aging progresses spontaneously and frequently. Even in Japan, the world's aging population is progressing, and in order to maintain national prosperity, some improvement measures must be taken. In this sense, the present invention must suppress aging within the range of possibilities. Means for solving the serious problem will be described below.
(1) “Claim 7” Rejuvenation and vitalization of the biological tissue structure is achieved by a comprehensive action centering on the GH secretion promoting action. Furthermore, by the DNA reform of living tissue stem cells according to “Claim 3”, healthy cells are induced to differentiate and exert a synergistic effect with actions such as promotion of GH secretion to construct a healthy and vigorous living tissue structure. To achieve. Furthermore, this fact can be maintained and sustained.
(2) Normally, thymic atrophy and T cells are reduced to one-tenth of the peak as aging progresses. "Claim 3" Healthy and vigorous T by DNA reform of bone marrow immune system stem cells Cells are induced to differentiate. In particular, HARP-A, HARP-B, and HARP-KK exert bone blood flow promotion, bone marrow tissue regeneration, and strengthening effects, which contribute to the regeneration and revival of thymic function. Furthermore, the enhancement of intestinal immunity according to "Claim 4" and "Claim 5" improves the aging suppression factor by strengthening immunity by the gospel that T cells are produced more and more from the small intestine epithelium.
(3) “Claim 8” Although it is common that aging progresses with the degeneration of blood vessels, arterial vasodilation, arterial blood flow promotion, capillary blood flow promotion, vascular wall strengthening, and further to the vascular wall Demonstrates the effect of improving repairs such as degeneration, breakage, and infarction.
The above is due to the synergistic action of all the components containing PGE ₁ produced from γ-linolenic acid, HARP-A mainly composed of sodium chondroitin sulfate, or HARP-B and HARP-KK. Furthermore, γ-linolenic acid and aged garlic extract maintain a normal cholesterol level and exert an arteriosclerosis improving action by increasing the HDL level. Furthermore, rejuvenation and soundening of the vascular tissue are achieved by the comprehensive action centering on the GH secretion promoting action.
In addition, protein synthesis and lipolysis function are demonstrated by promoting GH secretion, synergistically works on vascular wall repair strengthening, angiogenesis action, and hyperlipidemia improving action makes arteriosclerosis improving action complete, Contributes to the prevention of aging.
(4) Rejuvenation and activation of brain tissue according to claim 9 is an important factor for achieving rejuvenation and activation of a human living body. One of the important effects of HARP-A, HARP-B, and HARP-KK is that the brain is an organ that consumes 20% of budou sugar and oxygen of all living organisms, so that it promotes arterial blood flow, capillary blood This is achieved by promoting the flow.
[Claim 7] Rejuvenation and activation of brain tissue function is achieved by a comprehensive action centering on promotion of GH secretion. In particular, it is said that the number of nerve cells will be reduced by 100,000 per day, but as the population ages, the number will greatly decrease and forgetfulness will become intense. Although it is the most important issue for the aging deterrence, the present invention has been solved for the first time. This phenomenon occurs spontaneously, and there was no better way than just leaving it vaguely.
However, in the present invention, in addition to vitamin B ₆ and aged garlic extract, protein synthesis was greatly enhanced by the action of promoting GH secretion, and a nerve cell decrease inhibiting action was clearly recognized.
In particular, in the hippocampus, which is abundant in GH receptors, the tissue is activated and the memory ability and cognitive ability are restored by proliferation of nerve cells. This effect is achieved by maintaining the protective action of the nerve cell decrease in a protective manner by inducing differentiation of healthy nerve cells by the DNA reform of neural stem cells. This fact of the present invention is the most important matter for deterring aging.
(5) “Claim 10” The occurrence of cancer is diverse in all internal organs and tissues of the living body. In the field of treatment, treatment other than excision by early detection is extremely difficult. Treatment with anticancer drugs also has a low survival rate, and the occurrence of cancer is equivalent to a death sentence. Cancer is an important issue that the present invention must solve because it has a high frequency of occurrence and occupies the highest mortality rate. It is solved by induction of early healing and achievement of preventive action in the pretreatment stage.
(6) "Claim 11" and "Claim 12" Autoimmune diseases occurring in the human body have many types and various symptoms. In severe cases, there is a life risk. It is the bone marrow that dominates the living immune system. Furthermore, it is T cells that dominate immune cells. Both of these deficiencies cause a deficient state in the human immune system, leading to the occurrence of autoimmune diseases. Since the destruction of the human bioimmune mechanism means the destruction of the human living body, the palliative inhibitory action in the pretreatment stage of the present invention is impossible in the case of fulminant, but the preventive action, the early Since the achievement of the healing induction effect is certain, the problem of the present invention is solved. As described above, the necessity and importance of the present invention become clear, and the achievement of the three principles of non-disease, health and vitality of HARP-A, HARP-B, and HARP-KK is established.

The invention's effect

The difference is obvious when it comes to treatment or prevention. In the treatment of cancer, it is extremely difficult to treat because cancer is treated with an anticancer drug that has a surprisingly low survival rate even in a situation where the immunity of the cancer-bearing organism has been greatly reduced. Things are natural. Furthermore, there are cases where cerebral infarction and myocardial infarction cannot be treated.
While the importance of preventive medicine is suggested as described above, the present invention is a pioneer. Over a long period of decades, the achievement of the three principles of non-disease, health and vitality built on its research, experience and achievements (demonstration) led to a series of effects. This fact is clarified by “Claim 3” and below.

The effect in “Claim 3” is excellent. [Claim 7] By virtue of a series of actions centered on the GH secretion promoting action, a young and vigorous biological tissue structure is constructed.
Furthermore, “seventh aspect” of the brain, in particular, the brain stem function is activated and activated, whereby a healthy and vital function is exhibited.
Based on such a state, cAMP is produced by activating adenylyl cyclase present in the cell membrane from ATP produced in all tissues, and the action of GH and IGF-1 is enhanced. It is a tissue stem cell that exists to achieve the DNA reform of stem cells to induce differentiation of healthy and vital tissue cells to build healthy and vital tissue structures, and to preserve and protect living tissues Therefore, this action is preserved and sustained for a long time. This fact is proved by walking refreshingly even in the elderly, full of youth and vitality.
The above explanation demonstrates the generation of the best effect.

  “Claim 4” and “Claim 5” are symbols of effects generated by activating functions of a human living body. In an aging organism, macrophages and plasma cells tend to increase without changing the size of the spleen and lymph nodes. IgG antibodies and IgA antibodies are also increasing. However, the decrease in T cells is remarkable and it is unavoidable that the immunity is reduced, and it is easy to suffer from infectious diseases, and the incidence of pneumonia is particularly high. Furthermore, the incidence of cancer and autoimmune diseases also increases. The prior art suggests that T cell loss is due to atrophy of the thymus and is due to the hypothalamic hypofunction, which makes it impossible to secrete corticosteroids. However, in the present invention, it is recognized that it is the bone marrow that controls the immune system, and T cells that control the immune cells. Corticosteroids and glucocorticoids are factors that greatly reduce the body's immunity, and rather lead to tissue degeneration. By taking HARP-A or HARP-B and further HARP-KK, bone mass increase, bone blood flow increase, and bone marrow tissue regeneration enhancement action are established. “Claim 3” Healthy treatment by DNA reform of bone marrow immune system stem cells, Vigorous progenitor T cells are induced to differentiate and see revival of thymic function. Furthermore, by strengthening the intestinal immunity mechanism, the great gospel that more and more T cells are generated from the small intestine epithelial tissue demonstrates the effect of establishing a monumental tower that enhances the immunity of an aging organism.

[Claim 7] GH is secreted from the pituitary gland via the hypothalamus, which has the strongest affinity with PGE ₁ produced from γ-linolenic acid, and GH further inhibits the production of IGF-1 in the liver. Both promote and rejuvenate and revitalize the human body by demonstrating the repair and regeneration of living tissue through healthy cell differentiation and proliferation. This action was established by taking HARP-A or HARP-B, and further by using HARP-KK, and established a biological mechanism full of youth and vitality through a comprehensive function centered on GH action. Demonstrate the effect. Especially for postmenopausal women, in addition to GH secretion promotion, synergistic action with other components, protein synthesis promotion, lipolysis promotion, bone mass increase, morphological improvement by normalizing cartilage mass, feminine rejuvenation and vitalization Occurring, this great gospel means the beginning of a woman's new life, so we see the unprecedented effects that have occurred.
Further, “Claim 9” exerts a strong synergistic effect on the rejuvenation and activation of the brain, particularly the brain stem function, and greatly contributes to the construction of a vigorous tissue structure and the youth of the human body. In particular, there is a feeling that the spontaneous phenomenon that the number of neurons decreases 100,000 a day is left as it is, but in the present invention, the protein synthesis enhancing action by the GH secretion promoting action, the antioxidant of the mature garlic extract action, by further synergy effects involved in protein synthesis of vitamin B _6, potent neuronal cell loss inhibiting effect was demonstrated. This fact is an important part of generating the effect of the present invention.

[Claim 8] In the present background technical field, it should belong to the arteriosclerosis preventive range, and there is no example suggesting an accurate arteriosclerosis improving action. The effects produced by the present invention are groundbreaking because they are not possible with the general concept. The mainstream of the arteriosclerosis-improving action is PGE ₁ produced from γ-linolenic acid and chondroitin sulfate sodium arterial blood flow promoting action, capillary blood flow promoting action, and the blood vessel wall by synergistic action with other components It is due to strengthening, vascular wall degeneration, and revival of damage repair, but as an important factor, the improvement of arteriosclerosis is further ensured by the synergistic action with other components centering on GH secretion promoting action. Is to build a simple vascular tissue structure. [Claim 3] By the DNA reform of vascular tissue stem cells, healthy cells are induced to differentiate, and the vascular tissue structure can maintain the youthfulness and vitality for a long time.
As described above, the unexplained arteriosclerosis is overcome, and the occurrence of a breakthrough effect according to the present invention is observed.

[Claim 9] By achieving rejuvenation and activation of the brain, in particular, the brain stem, it is possible to construct a healthy tissue structure of a human body and to exert a healthy function. Based on this fact, the present invention sees the occurrence of exquisite effects. Its main function is as follows.
(1) The arterial blood flow and capillary blood flow are promoted to the brain, particularly the brain stem, and budosugar and oxygen are sufficiently supplemented.
(2) Although the heart is under the control of the brain stem, "Claim 8" prevents the occurrence of cerebral infarction and myocardial infarction with high mortality by achieving improvement of arteriosclerosis. This greatly contributes to the generation of exquisite effects of the present invention.
(3) “Claim 7” The structure of the brain full of youth and vitality, especially the brainstem, by synergistic action with other components centering on GH secretion promoting action, especially the structure of the brainstem, is demonstrated and exhibits healthy and vital functions Things will be possible.
(4) protein synthesis is enhanced by the "claim 7" GH secretion-promoting effect, aged garlic extract, by the synergistic effect of the vitamin B ₆ 1 day 100,000 decrease, of nerve cells that are said to not play again It exerts a strong deterrent action against the decrease. This fact is an epoch-making invention and greatly contributes to the generation of exquisite effects.

[Claim 10] Cancer is a disease having a high incidence and occupying the highest mortality rate. However, in the medical field, the cure rate is in the worst state by methods other than complete excision by early detection.
As proved in the corresponding section of the background art "Claim 10", the excellent anticancer agent Diemsar has a survival rate of only 8% per year. The one-year survival rate for 5-FU formulations is only 2%.
More serious side effects are listed, and in particular, the bone marrow function, which is the main head of immunity, is lowered, and the immune function is lowered such as leukocytes and neutrophils are decreased. At the stage of treatment, the cancer-bearing organism is in a situation where the balance between suppressor T cells and helper T cells is broken, and the immunity is greatly reduced. . Cancer treatment is extremely difficult because of similar effects in other anticancer agents. Therefore, with some exceptions, the advance notice of cancer is equivalent to the death penalty. In view of such a situation in the medical field, it is essential to establish early healing induction and preventive action in the previous stage of the medical field by HARP-A, HARP-B, and further HARP-KK. Therefore, the generation of the greatest effect having the necessity and importance according to the present invention will be seen.

[Claim 11] [Claim 12] Currently, antihistamines are mainly used for type I allergies, but they are merely symptomatic treatments. Furthermore, glucocorticoid products secreted from the adrenal cortex are exclusively used for the treatment of autoimmune diseases in the medical field. Glucocorticoids are the only unrivaled substance that exerts remarkable effects on autoimmune diseases, but they are merely symptomatic treatments.
2. Background Art As demonstrated in the corresponding claims of “claim 11” and “claim 12”, there are serious side effects, especially the atrophy of lymphoid tissue, and the immune function such as the reduction action of lymphocytes and acidophilic leukocytes Weakness is fatal. Furthermore, the development and progression of diabetes reverses the action of insulin, which is an anabolic hormone, and further functions to destroy biological tissues by suppressing growth factors, protein catabolism, and the like. However, in the medical field, it has been used with caution, and doses are gradually reduced at the time of discontinuation. We see the occurrence of the second life crisis because it is impossible to perform the function of protecting life by being secreted as necessary to the shock of the original anaphylaxis shock and intense stress. However, even in autoimmune diseases, glucocorticoid products have to be used because a severe crisis can cause a first life threat.
Under such circumstances, in an autoimmune disease, autoimmune T cells are activated to damage the self tissue and the tissue destruction proceeds. Since macrophages present in the cell cause the activation of autoimmune T cells by reducing the level of PGE ₁ PGE ₂ , by supplementing γ-linolenic acid and enhancing the level of PGE ₁ Suppresses activation of autoimmune T cells. In addition, HARP-A, HARP-B, and HARP-KK are also related to the fact that anti-inflammatory action is exerted by inhibiting the release of chemical substances from the cell chamber and suppressing the enhancement of vascular permeability. The order is the same as glucocorticoids. Certainly, its action is weaker than that of glucocorticoids, but it goes against all the strong side effects of glucocorticoids and acts significantly on the human body, so the difference is extremely large. Is.
As described above, the establishment of the palliative deterrent effect and the preventive action in the previous stage of the medical treatment of the present invention exhibits an effect that cannot be seen elsewhere.

  [Claim 6] The rejuvenation of the intestine age by intestinal cleansing has an important relationship with the rejuvenation and vitalization of the human body. HARP-A or HARP-B is the only one that shows normal defecation, and it excretes stool collected in the intestinal tract by promoting secretion of the large intestine wall, and cleans the intestine. The intestines of the newborn are only good bacteria, but the intestines of the elderly are filled with bad bacteria. The effect is completed by taking lactic acid bacteria, butyric acid bacteria, natto bacteria, brewer's yeast, etc. at the same time. This action means enhancement of brainstem function, which is different in dimension from other constipation drugs, and thus exerts an important effect in the present invention.

Related to “Claim 13”, the present invention is based on the long-term research, experience and achievements (development) of several decades before the field of medicine by the synergistic action of HARP-A, HARP-B, and HARP-KK. Induction of healing and establishment of preventive action at the stage have been achieved, leading to the remarkable effect of the present invention. The progress of medicine is remarkable, and new medicines are developed one after another in the medical field, and the results of treatment are constantly progressing. However, on the other hand, a retrograde action may occur in the construction of a healthy tissue structure of the human body. Decreased immune system function of immune system, decreased immune cells, and other serious side effects on biological functions in "Claim 10", lymph by glucocorticoid product in "Claim 11" and "Claim 12" It acts as a tissue destructive factor against the reduction of immune cells due to tissue atrophy and the restoration of human anatomy. [Claim 3] By taking an antipsychotic, it exerts an action against the DNA reform of tissue stem cells. Although there are other differences, there is a possibility of some side effects. In view of the above situation in the medical field, there is no obstacle to the induction of healing and establishment of preventive action in the previous stage of medical treatment according to the present invention, and the generation of excellent effects. I see.
Generation of the effects from “Claim 3” to “Claim 12” cooperates with each other, and finally, the generation of epoch-making effects is achieved by the synergistic action mechanism.

BEST MODE FOR CARRYING OUT THE INVENTION

Manufacturing method

In 4 capsules of HARP-A 1 dose, sodium chondroitin sulfate 500 mg, γ-linolenic acid 100 mg, aged garlic extract dry powder 400 mg, vitamin B ₆ 40 mg, placenta extract dry powder 400 mg

Manufacturing method

Production will be mass-produced, sodium chondroitin sulfate 500mg, aged garlic extract dried powder 400mg, vitamin _B 6 40 mg, mixed with an excipient at a rate of placental extract dry powder 400mg, finally adding γ Rinoren acid granules Filled into capsules. Take 4 capsules 3 times a day.
HARP-B 1 dose 3 capsules, chondroitin sulfate 500 mg, γ-linolenic acid 100 mg, aged garlic extract dry powder 400 mg, vitamin B ₆ 40 mg

Manufacturing method

Production will be mass-produced, sodium chondroitin sulfate 500mg, aged garlic extract dried powder 400mg, vitamin B ₆ 40 mg mixed with an excipient at a rate of, finally adding γ Rinoren acid granular and pear, the capsule Fill. Take 3 capsules, 3 times a day.
HARP-KK 1 dose 3 capsules, 400mg oyster shell heat-processed powder, 500mg oyster meat extract powder

Manufacturing method

Manufacture will be mass-produced. Add the excipients to 400mg of oyster shell heat-processed powder and 500mg of oyster meat extract powder to form granules and fill them into capsules.
Further technical details will be decided after consultation with the processing manufacturer.
HARP-A, or HARP-B and HARP-KK-containing components are composed of only human biological components or substances that enter the living body and function as biological components, and are non-disease, health and vitality in the human body. Achieve the principle. The best mode for carrying out the present invention will be described in detail below in “Claim 3”.

[Claim 3] Invention embodiment [Claim 7] Rejuvenation and activation of human anatomy by a series of synergistic actions centered on GH secretion promoting action [Claim 9] Normalization and activation of brain, particularly brain stem function By synergizing with the health and activation of human biological functions by restructuring DNA of all internal organs and tissue stem cells, healthy and vigorous internal organs and tissues are induced by differentiation. While constructing the structure, it works to preserve and preserve its effects. This fact is demonstrated by the fact that the users taking HARP-A, HARP-B, and HARP-KK corresponding components maintain their youth and vitality compared to other people.
In the previous stage of the medical field, depression led to DNA reform of stem cells and induction of healing, and the fact reached 70 cases. This non-depressive illness is caused by some shocking event. Although the response to shocks varies from person to person, a relatively mediocre person feels a greater shock, so a large amount of glucocorticoid is secreted from the adrenal cortex and becomes mentally elevated, but immediately changes to a depressed state. However, this phenomenon is temporary and cannot be sustained.
Because of this phenomenon, it is natural that all people with depression are induced to cure in a month.
With HARP-A, HARP-B, and HARP-KK, healing induction or preventive action is established by DNA reform of neural stem cells for persons with depression.
Recently, the problem of bullying and suicide in school has occurred, but it can be solved by taking HARP-B and HARP-KK. The reason is that bullying causes a stressful shock to the bullied child, and the glucocorticoid is secreted from the adrenal cortex. In the case of a child, a manic-depressed state occurs. See the outbreak of suicide. If it is a boy, it is solved by taking HARP-B, training the mind and body by sports every day, nurturing strong mental power, and achieving stem cell DNA reform.
Furthermore, by refining through a series of actions centered on promotion of GH secretion, a strong biological tissue structure as well as the spirit is constructed and solved.
A fact similar to this actually occurred, but was solved by reforming stem cell DNA by taking HARP-B and HARP-KK.
Manic depression is not a disease, so it does not belong to the medical field and is considered to belong to the field of the present invention. The long-term use of antipsychotic drugs goes against stem cell DNA reform, and addictiveness to drugs occurs, and taking the same medicine for more than 10 years makes it difficult to discontinue and shifts to refractory depression, It has recently been revealed that the frontal association field is dysfunctional. Furthermore, brain stem function decline occurred, and it became clear that it was remarkably manifested in the elderly. For example, an 80-year-old man with depression who suffered from depression suffered urinary leakage and fecal leakage due to brain stem function deterioration. We explained the necessity of HARP-B applicable products, but as a compensation for stem cell DNA reform, the addictiveness of anti-neurologic drugs is even more strongly expressed, so the regulation of anti-neuropathic drug administration and brainstem function activation I strongly encouraged me to do it. He has a strong attachment to life, participates in health care three times a week, always performs a light exercise every day, and is a depressed person, so he does not stay in bed or sleep for a long time. The person who was taking care of suddenly was admitted to the hospital for foot surgery, even though it was always executed, so the person himself was forced to be hospitalized without necessity. . The patient died in a month because his brainstem decline became worse and he was unable to swallow because he slept in bed. I felt the necessity of early stem cell DNA reform, normalization of brain stem function, and activation.

“Claim 4”, “Claim 5” and “Claim 6” In the human body, apart from the bone marrow thymus immune system which is the mainstream of immunity, lymphoid tissues for biological defense are distributed throughout the small intestinal epithelial mucosa. Yes. T cells are produced in this lymphoid tissue and are subjected to immune tolerance and immune response regulation, and are matured. The intestinal immunity mechanism centering on T cells has a powerful function. When receiving antigen sensitization, the intestinal mucosa fixed layer is in a normal and healthy state, and the human intestinal mucosa fixed layer has a 70- There are 80% T cells and IgA plasma cells, as well as 5-10% macrophages. In an aging organism, thymic atrophy occurs, the amount of T cells decreases to 10% of the peak, and it is easy to suffer from various infectious diseases. In particular, the incidence of pneumonia is high. In addition, the frequency of cancer and autoimmune diseases is increased due to a decrease in immunity.
As an embodiment of the present invention, as a result of having taken a relatively aged human living body and continuously taking a product corresponding to HARP-A, HARP-B, or HARP-KK, in all living bodies None of the cases were infected with a cold, flu, or any other infection. Of course, there was no cancer or autoimmune disease. A 72-year-old woman suffered from a cold and other infectious diseases without being affected because he / she was affected by HARP-B in spite of 3 family members suffering from influenza. I have never done anything, and once every 6 months I have a medical examination such as a stomach camera and chest x-ray, but I am confident that I will never get cancer. Of course, cancer patients cannot take cancer. Is equivalent to having a passport.
In addition, “Claim 6” intestinal cleansing is because the intestines of elderly people are filled with bad bacteria even though the intestines of newborns are filled with good bacteria. In view of the fact that gamma-linolenic acid contained not only strengthens the intestinal immunity mechanism but also fulfills systemic biological defense, it is considered necessary to make the conditions the same as that of the newborn by intestinal cleansing.

[Claim 7] The construction of a biological structure full of youth and vitality through the synergistic action of a series of components centering on the GH secretion promoting action by HARP-A or HARP-B and HARP-KK Although it is the most important factor in achieving the three principles of vitality, it further has a particularly significant effect on the stem cell DNA reform. Due to the fact that the anti-psychotic addictive nature and the effect of reversing the stem cell DNA reform have emerged too prominently, the construction of youthful and vital anatomy by the action centering on GH has led to the stem cell DNA reform. It is certainly expected to contribute greatly. In fact, those who take HARP-A, or HARP-B, HARP-KK are proved by maintaining their youth and vitality longer than others.
Furthermore, “claim 9” has a particularly great relevance to the health and activation of the brain, particularly brain function, and of course contributes to the construction of a healthy tissue structure of the brain and brainstem. the synergy with vitamin B _6, possible to suppress neuronal cell loss is an important effect unparalleled. HARP-A, HARP-B, and HARP-KK users have hardly forgotten things compared to other people. Even if forgetfulness occurs, it has a mysterious characteristic that it must be remembered the next day. With regard to this fact, particularly in the present invention, GH receptors are abundant in the hippocampus, and in the hippocampus, it is important that nerve cells proliferate, activate the tissue, and enhance memory ability and cognitive ability. This is a major factor. It has been demonstrated that GH exerts its vitality function strongly. A slightly stronger exercise, increase protein intake. At night, reduce sugar intake to maintain low blood sugar, eliminate bad stress, and strengthen good stress.
As a result of the above, the morphological rejuvenation and functional activation of the human body were remarkably confirmed by many people by taking HARP-A or HARP-B and further HARP-KK.

[Claim 8] The present invention is not based on animal experiments, but is established based on long-term research, experience and results (demonstration). As an important factor for improving arteriosclerosis, the synergistic action of the aging garlic extract and γ-linolenic acid maintains the total cholesterol level at a normal level, and particularly increases the HDL level called good cholesterol.
This fact was asked to 10 people and confirmed on the hospital examination form.
Furthermore, as an important factor, it has been confirmed that there has been no person with cerebral infarction or myocardial infarction in the past 5 years, including those taking chondroitin sulfate sodium, vitamin B ₆ alone or aged garlic extract, and other ingredients. done.
Furthermore, as an important factor that makes arteriosclerosis improving action decisive,
(1) PGE ₁ produced from γ-linolenic acid and chondroitin sulfate sodium arterial blood flow promoting action and capillary blood flow promoting action reduce the infarct size and exert a strong arteriosclerosis improving action.
(2) Due to the synergistic action of all components of HARP-A or HARP-B and HARP-KK, vascular wall strengthening, vascular wall degeneration, damage repair, and the like are exhibited.
(3) Regarding blood pressure, which is one of the risk factors for the occurrence of arteriosclerosis, in addition to the blood pressure normalizing action by the arterial blood flow promoting action and the capillary blood flow promoting action, the minimum blood pressure by ionized calcium in HARP-KK The action of lowering the value is a new invention not yet known. Ten people were asked to confirm the result of measuring several times with an automatic sphygmomanometer.
(4) "Claim 7" A healthy and vital vascular tissue structure is constructed by a series of actions centered on the GH secretion promoting action, and the arteriosclerosis improving action is completed.
It should be noted that vascular tissue strengthening by promoting protein synthesis by promoting GH secretion and hyperlipidemia improving action by promoting lipolysis are indispensable for improving arteriosclerosis.
(5) “Claim 9” Promoting arterial blood flow and capillary blood flow to the brain stem governing vascular function, and strengthening the supply of budo sugar and oxygen, thereby strengthening and revitalizing vascular function Is achieved, and the effect of improving arteriosclerosis is ensured.
As demonstrated by the above, the arteriosclerosis improving action is unparalleled, and the present invention can be achieved by taking a balanced diet, exercise therapy, etc. by taking HARP-A, HARP-B, and further HARP-KK. The best embodiment of this is constructed. In addition, it is demonstrated that there is no cerebral infarction or myocardial infarction in the person taking HARP-A, HARP-B, or HARP-KK corresponding component due to the arteriosclerosis improving action.

[Claim 9] The vitalization of the brain, particularly the brainstem function, leads to vitality and vitalization of the living body, but its action is "Claim 7" of the human body by a series of actions centered on the GH secretion promoting action. The construction of youthful and vital biological structure and "Claim 3" The synergy of three kinds of action to construct healthy and vital biological tissue structure by inducing differentiation of healthy and vital cells by DNA reform of human biological stem cells Although acting, the basis is still the brain and brainstem.
Good stress promotes GH secretion and acts significantly. It is related to noradrenaline and promotes crushing of the chest and nerve transmission action to cure depression and the like. Bad stress must be eliminated. It is related to adrenaline and leads to glucocorticoid secretion. It raises blood glucose level and exerts a catabolic effect on the living body to cause brain stem function decline.
In accordance with the above description, description will be made regarding normalization, restoration, and vitalization of brain and brainstem functions by HARP-A or HARP-B, and further by HARP-KK.
(1) Promotes arterial blood flow and capillary blood flow to the brain and brainstem by PGE ₁ , sodium chondroitin sulfate produced from γ-linolenic acid, and replenishes the function by vigorous supplementation of budosugar and oxygen, vitality Make it.
(2) “Claim 7” A healthy and vigorous tissue structure of the brain and brain stem is constructed by a series of actions centered on the GH secretion promoting action.
(3) “Claim 3” Healthy and vital cells are differentiated and induced by DNA reform of brain and brain stem tissue stem cells, and a healthy and vital brain stem tissue structure is constructed and preserved and preserved over a long period of time.
(4) Induce healthy and vigorous nerve cells by DNA reformation of neural stem cells in particular, and exert a conservation and preservation action. Further aging garlic extract, in addition to the synergistic effect of vitamin B _6, reduced deterrent effect on potent by GH secretagogue activity with protein synthesis function, nerve cells that are said to be reduced 100,000 daily spontaneously Demonstrate.
It is actually proved whether the brainstem function is healthy or activated by taking HARP-A, HARP-B, or HARP-KK. The most obvious phenomena are stool, urine, and sleep. An even more important phenomenon is that the atrial fibrillation-like arrhythmia that often occurs due to aging disappears, and the heart becomes healthy. Furthermore, breathing is performed smoothly and there is no such thing as suffocating. In particular, the vascular function is regulated, the original arterial blood flow and capillary blood flow are promoted, the phenomenon that the feet and hands are cold is eliminated, and the systemic function is activated.
This phenomenon has been demonstrated to have occurred in HARP-A, HARP-B, and HARP-KK corresponding product users, thereby normalizing, enhancing, and energizing brainstem function.
(Demonstration) 75-year-old male, due to diabetes, does not pass through the Budo sugar membrane to the brain and brainstem, causes lameness in the brainstem function, and immediately after leaving hyperglycemia, the brainstem function declines and reverses the above phenomenon Occurs.
The most troublesome is the occurrence of insufficiency in cardiac function. However, the dose of aged garlic extract in the HARP-B applicable product was increased, and it was repeated that light exercise was continued for 1 hour, the blood sugar level maintained the normal value, and the brain stem function activation phenomenon was clearly expressed.
This fact has revealed that brainstem function may be reduced and may be energized. In particular, symptoms of blood flow insufficiency such as some heart failure and cold limbs can be solved by HARP-A or HARP-B, and HARP-KK corresponding products. Furthermore, the factors required by each person are different, but it has also been found that the problem can be solved by eliminating the factors and improving the health and vitality of the brain stem function. Thus, the best embodiment is established.

“Claim 10” Cancer has a high frequency of occurrence and is the most powerful enemy factor for achieving the three principles of non-disease, health and vitality which are the object of the present invention. Also, if there are people who die at the age of 50 years, one in two people will die from cancer. However, in the medical field, cancer treatment is extremely difficult, and the survival rate by anticancer drug treatment etc. is surprisingly low by methods other than resection by early detection. In view of the above, the establishment of early healing induction and preventive action in the pre-treatment stage is the most important part of the embodiment of the present invention.
(1) By the synergistic action of “claim 9”, “claim 7” and “claim 3”, normal and healthy cells are induced to differentiate from each tissue stem cell, and further, cAMP is enhanced, and nucleic acid in HARP-KK As a result of supplementation, DNA copies of cell division are also accurately performed, and abnormal cells such as cancer cells cannot be generated.
As described above, the embodiment for establishing the cancer prevention effect is established.
(2) Even if abnormal cancer cells that do not normally occur are generated, cAMP of the cancer cells is increased to induce differentiation into normal cells.
(3) By enhancing bone marrow function, healthy and vital lymphocytes, particularly precursor T cells, are differentiated and induced by bone marrow immune system stem cells, and the bone marrow and thymic immune mechanisms that form the mainstream of immunity become complete. Furthermore, in the small intestinal mucosal epithelial tissue, the strengthening of the human immune system is established by strengthening the intestinal immune system centered on immune tolerance, immune regulation, and matured T cells.
As described above, induction of early cure of cancer development is established, and the best embodiment is completed.
Background Art “Claim 10” Applicable facts (Demonstration 1) A 70-year-old man, Sharqli did not stop for 2 days, healed with Chinese medicine, and then his family was informed that his life was 3 months due to the occurrence of liver cancer . He was not informed that liver cancer had occurred, but was in a state of general exhaustion. Since he was not taking any anticancer drugs or other drugs, he took the corresponding HARP-B component and gradually turned to the best. 2 months Each time they were examined at the hospital and asked to present an examination form, they continued taking for 6 months. As a result, their physical condition returned to a healthy state, and all the examination forms returned to normal values. Because he did not know the fact that he was sentenced to cancer for 3 months, he suddenly stopped taking HARP-B. Although I was advised not to stop taking the medicine three times over the phone, there is no help for it because I don't know that the person has cancer. Because the condition recovery was so complete, I thought that it was probably cancer and left it as it was. About 2 years later, it was found that he died, and it was confirmed that he had liver cancer. When taking the HARP-B corresponding component continuously, it is certainly expected that the healthy state is maintained even now.
(Demonstration 2) 75-year-old female, pancreatic cancer, 3 months notice of hospital survival, rash occurred in Diemzar, 5-FU chemical use, healthy for 6 months while taking the same drug and HARP-B relevant ingredients The state was maintained. Thereafter, the use of 5-FU chemicals was suddenly stopped. The condition gradually worsened and food intake became impossible. Of course, the corresponding HARP-B component was also discontinued. However, although the hospital survival notice was three months, I was able to survive for more than one year.
When judging from the fact that the 5-FU one-year survival rate based on the interview form provided by Eli Lilly Japan is only 2%, the significance of HARP-B is confirmed and the existence value of HARP-B is demonstrated. .
(Demonstration 1) (Demonstration 2) was released from the medical field after receiving a notice of a three-month survival period, so taking HARP-B is a correct action.
In the case of (Demonstration 1), since the use of anticancer agents and others has been discontinued, healing should be successfully induced in 6 months by taking the corresponding HARP-B component alone, and further completed by continuous use.
In the case of (Demonstration 2), it is difficult to treat pancreatic cancer. Because of the occurrence of a rash on Diemzar, an excellent anticancer drug with a one-year survival rate of 8%, a 5-FU product with a one-year survival rate of only 2% must be used. It's a shame that there wasn't. However, since the normal state was maintained for 6 months, it is thought that it would have been better to continue using the 5-FU product without stopping the use.
This is because the side effects of 5-FU chemicals are alleviated by the HARP-B product. Furthermore, since the immunity of the cancer-bearing organism is extremely reduced, synergism with the anticancer agent is always exhibited by the enhancement of immunity, and there is a possibility of induction of healing. This is because the normal state was maintained by the combination therapy for 6 months. Miracles do not occur, but are established on the basis of correct theory. By anti-cancer agent, pancreatic tissue stem cells and differentiation-induced abnormal cancer cell DNA inhibition action, even if temporary, decrease cancer cells and increase cancer cell cAMP, and induce to normal cells It is important to control the increase as well. In particular, DNA reform of stem cells is the most important matter. As described above, in the case of the anticancer agent alone, the state of survival rate of only 2% was greatly improved. In this case, since the 5-FU product and the HARP-B corresponding component were maintained in a normal state while taking the 5-FU product, the health condition is maintained for a longer period unless the 5-FU product is suddenly stopped. It seems that things were possible.
This is demonstrated by (demonstration 1) that a male with liver cancer who had only 3 months of survival noticed that healing was achieved by taking 6 months of the HARP-B product.
(Verification 1) (Verification 2) is an important matter of the embodiment of the present invention.
"Necessity of embodiments of the present invention that are a social problem"
Recently, hepatitis C due to blood infection has become a social problem, but its treatment is based on interferon, and there is no other special treatment. Hepatitis C gradually deteriorates from about 55 years old due to a decrease in the immunity of the living body, leading to the occurrence of cirrhosis and liver cancer. The immune system of the human body is formed by complex factors and cannot be completed by the current main treatment, interferon monotherapy.
As will be apparent from (Demonstration 1), it is completed for the first time by enhancing the overall immunity of the human body. Early healing induction is completed by taking HARP-A, HARP-B, and further HARP-KK in conjunction with interferon treatment, leading to the solution of social problems. In particular, it was confirmed that HARP-A is the only substance that can significantly improve the values of GOT and GPT in hepatitis C patients.

“Claim 11” and “Claim 12” Inflammation is a phenomenon that occurs as part of an immune response in a human living body, but it can also act as a biological destruction factor like an autoimmune disease. In the medical field, corticosteroids and glucocorticoid drugs that have the only dramatic effect on autoimmune diseases are used. Although it is used carefully in treatment, it may be necessary for long-term use. Adrenocortical function declines, adrenal atrophy occurs, and glucocorticoids cannot be secreted when anaphylactoid shock is necessary, so even if autoimmune disease itself is severe, it is a life risk factor, Look at the occurrence of a second risk factor.
Means for solving the following problems "Claim 11" and "Claim 12" include serious side effects of corticosteroids and glucocorticoids, and severe side effects of HARP-A, HARP-B, and HARP-KK. The fact that all significant functions are exerted on the human body was described.
Glucocorticoid (1) Promotes hepatic glycogenogenesis and gluconeogenesis, suppresses the intake of sugars other than the liver, heart, and brain, raises the blood budo sugar level, and causes diabetes-like symptoms. (2) In order to promote protein degradation, the degeneration tendency of visceral tissues of the living body is expressed, and the function of the organ in which supplementation of budo sugar is suppressed occurs. Occurrence of edema (circular face) is high due to protein catabolism, gastric ulcer due to promotion of gastric juice secretion, and decreased renal sodium excretion. Increases the amount of free fatty acids in the blood by promoting lipolysis and observes the occurrence of blood hypermaemia. (3) Lymphoid tissue is atrophy, lymphocytes and acid leukocytes are decreased, infection is induced by immunity reduction, and hatred.
(4) Reduce bone mass (osteoporosis) and induce pathological fractures.
(5) Adrenal atrophy occurs due to long-term administration of a glucocorticoid preparation, and glucocorticoid cannot be secreted when a shock or the like is required. (6) Demonstrate androgenic action.
(7) Demonstrate thrombus generation. (8) Muscle atrophy occurs due to protein catabolism.
(9) Wound healing disorder occurs. (10) Causes edema and hypertension.
(11) It has the action of going against growth factors.
HARP-A, or HARP-B, HARP-KK completely reverses the serious side effects of glucocorticoids. (1) For diabetes, induction of natural healing and complete prevention of secondary symptoms by combined use of exercise therapy. (2) Rejuvenation and vitalization of all visceral tissues can be achieved by sufficiently supplementing budo sugar and oxygen by promoting the synthesis of protein, the arterial blood flow, and the venous blood flow by the action mainly of GH secretion. Of course, gastric ulcer healing effect, renal function soundness, hyperlipidemia improving effect is exhibited. (3) Strengthening of bone marrow, thymic immune system, and intestinal immune system has been established, and it has excellent defense against infectious diseases. (4) Due to the ionized calcium in HARP-KK, the bone mass maintains a normal value of 100%, and there is no fracture. (5) Contributes to sound adrenal function through the hypothalamus.
(6) Has strong relaxation properties with all steroids and exhibits harmonious action.
(7) Reduces thrombus size and exerts cerebral infarction and myocardial infarction generation inhibiting action.
(8) The muscle tissue is strengthened by the protein synthesis promoting action, the arterial blood flow and the capillary blood flow promoting action on the muscle tissue. (9) It suppresses the increase in blood vessel permeability, prevents leukocyte migration, and exerts a powerful defense force against bacteria, thereby exerting a tremendous early healing power. (10) Due to promotion of renal blood flow, renal function remains normal and edema cannot occur. Furthermore, the blood pressure is maintained at a normal value, which promotes arterial blood flow and capillary blood flow in all human tissues.
Furthermore, normalization of diastolic blood pressure is particularly pronounced. (11) Rejuvenation and vitalization of the human body are achieved through a series of actions centered on the GH secretion promoting action.
Autoimmune disease, which is said to be an intractable disease, is a serious risk factor for the living body, but rather than the autoimmune disease itself, the cause of the failure of the biological immune mechanism, and the seriousness of glucocorticoids used for treatment It describes important embodiments for maintaining the homeostasis of human body such as side effects.
(1) Regarding the anti-inflammatory action, HARP-A or HARP-B and glucocorticoid drugs exhibit the same function. In any case, the chemical substance is released from the cell chamber and the increase in the permeability of blood vessels is suppressed, thereby preventing the occurrence of inflammation.
(2) As described above, glucocorticoids have serious side effects (1) to (11) and may cause life threatening factors due to long-term use.
(3) HARP-A or HARP-B counteracts the serious side effects of glucocorticoids (1) to (11), and as described in (1) to (11), Therefore, there is no possibility that the risk factor of life will be generated by acting significantly, stocking up surplus health.
(4) The most important action of a glucocorticoid is to relieve a strong shock-like condition when it occurs. With glucocorticoids, I have encountered several deaths that seem to have saved lives.
The need for an unusual best embodiment In the medical field, there are serious problems between autoimmune diseases and glucocorticoids as described in (1), (2), (3) and (4).
Moreover, the present invention and the medical field are different in dimension, and the present invention is different from the medical field, and the establishment of healing induction and preventive action in the previous stage of medical treatment It is a place to aim. However, since human life is something that cannot be changed, it must be solved by searching for some method.
In conclusion, the anti-inflammatory action of HARP-A, HARP-B, and HARP-KK in autoimmune diseases is far less than that of glucocorticoids, but cAMP enhancement is related to the mechanism of action. The combined use greatly enhances the synergistic effect and significantly reduces the amount of glucocorticoid drugs used. Furthermore, the serious side effects of glucocorticoids are almost eliminated, and the living body is protected and protected. A mandatory embodiment is formed.

“Claim 13” is the best embodiment of the present invention by the aging deterrence theory within the range of possibilities.
(1) The best embodiment in biomorphic soundness It is confirmed by a hospital examination that bone mass becomes 100% normal in one year by ionized calcium in HARP-KK, HARP-A, or HARP-B By taking, the amount of cartilage returns to normal within a certain period. Furthermore, through a series of synergistic actions centered on GH secretion promoting action, muscle tissue is also sounded, and a morphological structure full of youth and vitality of the human living body is built, and the appearance of a person walking refreshingly appears. The best embodiment is established.
(2) Best Embodiment by Functional Health of Living Body It is the brain, particularly the brain stem, that controls human biological function. The brain stem dominates functions that are absolutely necessary for the human body to maintain life. By taking HARP-A or HARP-B, the arterial blood flow and capillary blood flow to the brain, especially the brainstem, are promoted, and the brain, especially the brainstem, especially the brainstem, which is most needed, is fully supplemented, and the brainstem is directly controlled. The functional soundness of the human living body is completed by acting not only on the function being performed but also on the regulation of the autonomic nervous function governed with the hypothalamus.
This fact is proved by the fact that healthy functions of the heart and blood vessels, swallowing, sleep, breathing, defecation, urination and the like have been actually achieved in the human body. This establishes the best embodiment.
(3) The best embodiment by sounding the internal organs of the body By taking HARP-A or HARP-B and further HARP-KK, a healthy and vigorous visceral organ by a series of synergistic actions centering on GH secretion promoting action An organizational structure is established.
Strengthening the brain and brainstem functions also has a synergistic effect. Furthermore, the visceral tissue is made healthy and energized by promoting arterial blood flow and capillary blood flow to the visceral tissue by HARP-A or HARP-B. Furthermore, by virtue of the visceral tissue stem cell DNA reform, healthy cells are induced to differentiate and are maintained and maintained with a healthy internal tissue construction. It is confirmed by many people that this fact is actually maintained in a healthy state without any abnormality in the visceral tissue mechanism in the person taking HARP-A or HARP-B, Proven.
Thus, the best embodiment of the present invention has been established.
(4) Best embodiment by sounding of living immunity By taking HARP-A or HARP-B, and further by HARP-KK, bone blood flow is promoted, bone marrow tissue is revived, regeneration is enhanced, and bone marrow immune system stem cells are healthy. Lymphocytes are induced to differentiate, and in particular, progenitor T cells are immune-tolerated, immune-regulated and matured in the thymus. This achieves soundness of the bone marrow and thymic immune mechanisms, which are the main components of the biological immune mechanism. Furthermore, by strengthening the intestinal immunity mechanism centering on T cells that are generated in the small intestinal mucosal tissue by enhancing intestinal peristalsis and promoting blood flow in the small intestinal mucosal tissue, Immunity enhancement is established. This fact is proved by the fact that none of the aging organisms suffered from colds, influenza, or other infectious diseases.
Thus, the best embodiment of the present invention is established.
(5) Best Embodiment by Inducing Early Healing for Cancer, Cerebral Infarction, and Myocardial Infarction with High Mortality, Establishing Preventive Action By taking HARP-A or HARP-B and further HARP-KK, "Claim 3" Normal and healthy cells are induced to differentiate by the DNA reform of each tissue stem cell. Furthermore, due to the cAMP enhancing action and nucleic acid supplementation, DNA copy at the time of cell division is also accurately performed, and there is no possibility of generation of abnormal cancer cells. Even if an abnormal cancer cell is generated, it is possible to enhance cAMP of the cancer cell and induce it to a normal cell. Furthermore, as described in (4), the induction of early cancer cure and preventive action are surely achieved by strengthening the bone marrow, thymus immune system immune system, and intestinal immune system.
This fact indicates that there is no cancer occurrence among those who take HARP-A, HARP-B, and HARP-KK. Furthermore, immunity is strengthened by the fact that none of the elderly suffered from colds, influenza, or other infectious diseases. Furthermore, regarding the achievement of cerebral infarction, myocardial infarction, and early healing induction preventive effect by HARP-A or HARP-B, and further by HARP-KK, the best embodiment “Claim 8” has the effect of improving arteriosclerosis. However, the action of promoting arterial blood flow and capillary blood flow on the brain and heart is the most important factor for preventing infarction. In the event of an infarct size reduction that has occurred, the blood vessel strengthening action, vascular wall degeneration, and damage repair regeneration action are particularly important factors.
The above actions achieve the object by reforming the brain and cardiovascular tissue structure through a series of actions centered on "claim 7" GH secretion promoting action. Going one step further, building a healthy tissue structure by reforming the brain and heart body, going one step further, nerve cells by synergistic action of mature garlic extract, vitamin B6 and the function of enhancing protein synthesis by promoting GH secretion The reduction inhibitory action is an important part of the present invention. The brain stem dominates the heart and blood vessels, and by strengthening the function of the heart and blood vessels, the arterial blood flow and capillary blood flow are enhanced, and the brain stem function is further strengthened by sufficient supply of budo sugar and oxygen. In addition, the soundness of the heart function eliminates the occurrence of cerebral infarction due to the clotted blood flow being sent to the brain. There is no cerebral infarction or myocardial infarction in the patients taking HARP-A, HARP-B, or HARP-KK, but the improvement effect has already appeared clearly in cerebral infarction patients.
Thus, the best embodiment of the present invention has been established.

Claims (13)

It relates to HARP-A. HARP-A is sodium chondroitin sulfate, gamma Rinoren acid, aged garlic extract, placenta extract, contains vitamin B _6, non-disease of the human body, health, achieving three principles of vitality, and intended to maintain up to 100 years old To do.
Since the target action is exerted by the synergistic action of the five components containing HARP-A, which is not possible with a single component, the target action may be reversed. Thus, one substance called HARP-A is formed. The HARP-A-containing component is composed of all human biological components or components that enter the body and function as human biological components.
Since the human body is a single body and all visceral tissues are related to the maintenance of the living body, HARP-A significantly affects all visceral tissues and is one step for all diseases. It is a fundamental constitution-improving drug belonging to so-called preventive medicine that exhibits a healing effect before. Since HARP-A is composed of the minimum essential components excluding all components that can be ingested with meals and the like, there is a need for a balanced diet and moderate exercise. In the following, the significance of the mechanism of action of HARP-A and the necessity due to excellent action are listed in claims 3 and below, but all of them are innovative and worthy of patent. It relates to HARP-B. HARP-B contains sodium chondroitin sulfate, gamma Rinoren acid, aged garlic extract, vitamin B _6, non-disease of the human body, health, achieving three principles of vitality, and an object thereof is to maintain up to 100 years old. The same action as described in claim 1 below, except that the placenta extract is excluded and it is composed of four components. When the visceral atrophy and physical strength decrease are relatively old, the tissue regeneration and the physical strength enhancing action are remarkable. It is preferable to use HARP-A containing the placenta extract to be exerted. The present invention relates to the human body remodeling theory and HARP-KK by stem cell DNA reform. It is a human body remodeling theory for differentiating and generating healthy cells from healthy stem cells to form a healthy biological tissue structure. There are about 60 trillion cells in the human body, but they are not all the same, and all forms are different depending on each function and each tissue structure. Originally, stem cells have the ability to self-correct, repeat indefinite division, and induce differentiation into various kinds of cells to maintain life forms. For example, immune cells, nerve cells, muscle cells, and other organ cells are all differentiated from stem cells and grow into mature cells. Therefore, stem cells are essential for protecting human living cells. In addition, DNA exists in the nucleus of the stem cell, and each person has a personality. This DNA reform of stem cells is essential for, for example, strengthening immunity, preventing various diseases, strengthening functions of central and peripheral nerves, and strengthening all other human tissue structures.
HARP-A and HARP-B are composed of the minimum necessary components for achieving the above-mentioned purpose. Substances that can be taken in the diet and chemical substances that can adversely affect DNA are excluded. In addition, it is difficult to ingest at meals, but as an essential calcium and nucleic acid supplement, HARP-KK containing HARP-KK combined with heat-treated oyster shell powder and oyster meat extract to promote absorption of HARP-A or HARP-B The gaps can be filled and DNA reform and stem cell reform can be completed.
Stem cell DNA reform, that is, the theory of human body remodeling by stem cell reform, is an epoch-making invention that does not yet exist. The human body continues to take HARP-A or HARP-B and HARP-KK, and the human body maintains a healthy and healthy state. It is possible to build an organizational structure. In the human living body, budo sugar is converted into carbon dioxide gas and water by generating energy through the TCA cycle via viruvic acid and acetyl CoA. Furthermore, when undergoing complete aerobic metabolism, 38 ATPs are produced from one molecule of budosaccharide. ATP is produced in any tissue, and PGE ₁ produced from γ-linolenic acid activates adenylyl cyclase present in the cell membrane to generate cyclic AMP in all tissues of the human body. In this way, the reform of the human body is achieved because all the cells that are further differentiated and normalized are restored to normalization and normalization of the internal organs stem cells. Furthermore, the supply of nucleic acid with HARP-KK is even more reliable. The above is an epoch-making invention like no other, and at the same time is an important factor in achieving the three principles of non-disease, health and vitality. It relates to immune tolerance and immune response. In the immunity mechanism, biological defense is complete only when both immune tolerance induction and aggression against foreign substances are provided. That is, it is an essential condition that an immune response is accurately performed. At the time of foreign body invasion, immune cells, in particular, Plastaglandin E ₁ (hereinafter referred to as PGE ₁ ) and Plastaglandin E ₂ (hereinafter referred to as PGE ₂ ) secreted by macrophages are T cells responsible for specific immunity and Suppresses excessive immune response to macrophages. PGE ₁ PGE ₂ plays an important role for thymic hormone, which is a factor that regulates maturation and differentiation of progenitor T cells.
The thymus is divided into two types: cortical thymic T cells that are present in the cortex and medullary thymic T cells that are present in the medulla. Yes.
In order for T cells that are immunocompetent cells to be differentiated and matured, released into tissues, and recruited, they must be changed from cortical T cells to medullary T cells. It is thymic hormones and macrophages that are responsible for this important role until the differentiation and maturation of intrathymic T cells. This series of functions of thymic hormone is served through the action of increasing the cyclic AMP of PGE ₁ PGE ₂ . Furthermore, although the immune excess of T cells, which are immunocompetent cells, is suppressed in response to foreign body stimulation, macrophages regulate the production of PGE ₁ PGE ₂ according to the immune response in vivo, so that PGE ₁ is necessary as necessary. The level of PGE ₂ can be rapidly reduced to achieve maximum T cell function.
The above suggests the necessity of harmony between immune tolerance and immune attack and the importance of accurate immune response for biological defense, but PGE ₁ PGE ₂ plays this main role. Thus, it is claimed that PGE ₁ produced from HARP-A or HARP-B-containing component γ-linolenic acid, together with PGE ₂ , exhibits the most important immune tolerance for immunity and the regulation of immune response. 5. Relevant to strengthening the immune system and enhancing immune reserve, it is an important factor in achieving the three principles of non-disease, health and vitality in the human body. It relates to the importance of intestinal immune mechanisms. The human body has an immune mechanism specific to the small intestinal epithelium that is different from the normal immune mechanism. This immune mechanism has the ability to induce immune tolerance and an immune response in the positive direction against foreign substances that have entered the human body. In this regard, claim 3 suggests that PGE ₁ produced from γ-linolenic acid and PGE ₂ can be used via macrophages. Such an immune mechanism is universally found in mucosal tissues throughout the body. Lymphatic devices that recognize foreign substances and protect the living body are distributed throughout the small intestinal epithelial mucosa. The place where B cells, which are precursor cells of plasma cells that produce IgA that specifically binds to foreign substances, are differentiated is a lymph apparatus represented by Peyer's plate. T cells and B cells sensitized with this Peyer's plate differentiated from the Peyer's plate, matured into the vasculature from the thoracic duct via the mesenteric lymph nodes and matured specifically in the paraspinal region of the Peyer's plate It returns to the intestinal tract from the vasculature and is distributed between the small intestinal mucosa fixed layer and the small intestinal epithelial cells according to their functions. B cells finally differentiate into IgA plasma cells in the mucosal anchoring layer. In the intestinal mucosa fixed layer, there are many IgA plasma cells in a healthy and normal state, and the amount thereof corresponds to 70 to 80% of the whole human body. There are many T cells, and the amount reaches almost 70 to 80%, which is the same as that of plasma cells. There are also 5-10% macrophage cells. This amazing fact has significant significance for the human body. Enhancement of the intestinal immune mechanism by HARP-A or HARP-B and further HARP-KK means enhancement of immune reserve, which means enhancement of health reserve. This fact clarifies the significance of HARP-A, HARP-B, and HARP-KK, and this fact suggested by claims 4 and 5 is a serious invention.
The immunity against foreign substances such as viruses and bacteria in the outside world is too weak for a newborn living body that has been born as a single individual away from the mother and placenta that have been protected until now. What strengthens this immunity is the intestinal immunity mechanism enhanced by PGE ₁ produced from IgA antibody and γ-linolenic acid contained in breast milk. PGE ₁ enhances small intestinal peristaltic movement, promotes blood flow in the small intestinal epithelial mucosa, and is produced from small intestinal epithelial cells. Serve purpose. The specific intestinal immunity mechanism is as follows. T cells that have the functions underlying immunity are generated in bone marrow or small intestinal epithelial tissue. Progenitor T cells generated in the bone marrow enter the thymus and become thymic T cells that settle in lymph nodes. T cells generated by small intestinal epithelial cells settle in the intestinal mucosa fixed layer. In addition, proliferation of T cells cannot be differentiated by the corresponding antigen in lymph nodes, spleen, peripheral blood, or other tissues, and can only proliferate and differentiate in thymus or small intestinal epithelial tissues. The same receptor exists in the thymus and small intestine epithelium. Furthermore, although NK cells are derived from bone marrow, their differentiation is widely distributed in small intestinal epithelial tissues without depending on secondary tissues such as spleen and thymus. The action of this NK cell is functional differentiation and induction by interferon, but it is actually activated through T cell-derived interleukin 2 that accompanies activation of T cells resident in the small intestinal epithelial tissue.
In this way, in addition to the T cell damage activity, the damage activity caused by NK cells committed to the T cell lineage is enhanced. The immune mechanism formed by these T cells and NK cells is the core of intestinal immunity, but has significant significance in that both were constructed without going through the thymus. Furthermore, there are many T cells between small intestinal epithelial cells, but many B cells and plasma cells are distributed in the mucosal fixed layer. The lymph nodes of the submucosal lymph apparatus are composed of B cells. Other macrophage cells are also present in the mucous membrane fixed layer, and the living body's immune system is composed of cells having different functions such as T cells, B cells, and macrophages. Foreign matter that has entered the body is processed mainly by cellular immunity by these immune cells.
Summarizing claims 4 and 5, the PGE ₁ small intestinal peristalsis generated from γ-linolenic acid contained in breast milk is enhanced, and the blood flow of the epithelium of the small intestine is increased, thereby increasing T cells, NK The intestinal immune mechanism established by the small intestinal epithelial tissue centered on lymphocytes that do not require thymus such as cells protects the newborn organism from foreign substances. This fact indicates that the intestinal immunity mechanism is not completely isolated, and that when the immune system is weakened, that is, the immune system is in a state of immune dysfunction like the neonatal body, the function is significantly activated for the defense of the human body. Prove that. In the intestinal immunity mechanism, T cells are not generated from the bone marrow but are generated in the small intestine epithelial tissue, and matured in the small intestinal epithelial tissue to exert their functions. The sensitized T cells mature and occupy 70-80% of the whole human body in the intestinal mucosa fixed layer. Furthermore, there are almost the same number of IgA plasma cells differentiated from B cells. Furthermore, in the intestinal immunity mechanism, immune tolerance and regulation of immune response have been established, and the establishment of a strong immune system greatly contributes to the human body. The enhancement of intestinal immune function suggests a significant link to the achievement of non-disease, health and vitality of HARP-A, or HARP-B, HARP-KK. Furthermore, in the bone marrow and thymus immune system, when bone marrow or thymus failure or all precursor T cells differentiated from bone marrow stem cells fail to function, antibodies cannot be generated from B cells, resulting in immune function. Therefore, the enhancement of intestinal immunity function by γ-linolenic acid contained in breast milk is a serious invention. Furthermore, it becomes an important factor for achieving the three principles of non-disease, health and vitality.   Regarding intestinal cleansing. As the human body ages, the decrease in intestinal peristalsis becomes more prominent. As a result, the number of defecations decreases, often over 7 days. This is because of the increase of enterotoxins and peracid lipids, and the rapid aging of the human body is observed. The intestines of newborns are filled with good bacteria, but bad bacteria occupy the intestines of aging adults. In HARP-A or HARP-B, γ-linolenic acid exerts an action to enhance intestinal peristalsis and synergizes with the action of chondroitin sulfate sodium to retain water in the stool in the lower part of the large intestine. See unparalleled normal comfort. In addition, it promotes mucus secretion in the large intestine and discharges black stool, also referred to as stool, stuck to the folds of the intestine. In addition, it is necessary to take any or all of butyric acid bacteria, lactic acid bacteria, natto bacteria, etc., and by this, intestinal cleansing is achieved, and rejuvenation of the intestine age leads to rejuvenation of the human body itself. Normalization of defecation means a healthy state of brainstem function. Intestinal cleansing with HARP-A or HARP-B-containing components is an important factor in achieving non-disease, health and activity in the human body. Furthermore, this is an important invention. It relates to the theory of human body remodeling by growth hormone. PGE ₁ produced from γ-linolenic acid acts on the diencephalon and hypothalamus and promotes secretion of the anterior pituitary hormone ACTH. This ACTH exerts an action of promoting the production of corticosteroids. In addition, ACTH has a strong recombination with a receptor present in the adrenal cortex as an extra-adrenal action, and activates the membrane adenylyl cyclase to produce cyclic AMP. ACTH thereby promotes growth hormone secretion and insulin secretion. Since insulin promotes sugar oxidation and acts as an anabolic hormone, synergy with growth hormone, a growth factor, is the most important factor in producing adult youth and vitality. Growth hormone promotes tissue amino acid uptake, protein synthesis from amino acids, and RNA synthesis. This effect acts synergistically with vitamin _{B 6} in the HARP-A. It also breaks down fat and releases fatty acids and glycerol. Ingestion of glucose is promoted, but when hyperglycemia occurs, oxidation of budo sugar is suppressed. Furthermore, it promotes the reabsorption of water and electrolytes in the renal tubule. Growth hormone secretion increases markedly during sleep, especially during the first slow wave sleep. In order to promote secretion, protein intake, exercise, mental stimulation, and maintenance of hypoglycemia are necessary. The three principles of non-disease, health and vitality are achieved by promoting insulin and growth hormone secretion of HARP-A or HARP-B.
In addition to the above effects HARP-A, or HARP-B-containing component, the synergistic effect of the insulin by the sulfur-containing amino acids during the aging garlic extract, protein synthesis of vitamin B _6, sodium chondroitin sulfate, gamma Rinoren acid, tissue by placental extract The synergistic effect of regenerative angiogenesis and growth hormone is unique.
In general, animals end their life when the reproductive period is over, but this is not possible in the human body. In particular, women reach menopause at an average age of about 55 years, but since then, the secretion of female hormones has decreased, so that hyperlipidemia due to obesity and the occurrence of osteoporosis increase due to a significant decrease in bone mass. Female menopause means the end of the reproductive period in animals. However, the gospel of promoting growth hormone secretion leads to youthfulness as a woman and attractive longevity as a woman. Furthermore, the slimming beauty method is established by the action of promoting lipolysis, protein and RNA synthesis. In addition, growth hormones act on the bone ends and, depending on the effort, facial facial changes occur spontaneously.
Especially in the case of females, even if bone mass and cartilage are reduced due to HARP-A and HARP-KK, the bone mass is restored to normal in one year, and the cartilage mass is also special. It is possible to restore to the normal state except for. Therefore, regardless of aging, a refreshing appearance appears in both appearance and physical appearance. Also in men, taking HARP-A or HARP-B and further HARP-KK, stronger exercise, mental vitality, hypoglycemic maintenance, deep sleep, strongly promotes growth hormone secretion, bone mass, cartilage As well as increasing the amount, protein synthesis is strengthened, muscle development is remarkable, visceral function is also strengthened, and robust living body formation is realized.
In particular, since the strength of affinity between PGE ₁ and growth hormone is unparalleled, other factors including HARP-A, HARP-B, HARP-KK and other factors are also taken into account. The human body modification theory is a novel and important invention. It is an important factor in achieving the three principles of non-disease, health and vitality. Regarding arteriosclerosis. Arteriosclerosis is an arterial lesion caused by thickening and hardening of the blood vessel wall, and causes ischemic heart disease such as myocardial infarction, cerebrovascular disorder, aortic aneurysm and the like. Arteriosclerosis is composed of three types: medial sclerosis, arteriole sclerosis, and atherosclerosis.
The human body is said to age with blood vessels, and brain and cardiovascular disorders occupy the top of mortality with cancer. The main risk factors for these vascular disorders are hypertension, hyperlipidemia, diabetes, hyperuricemia, etc. In reality, one in two middle-aged women has hyperlipidemia. It is said that about 40% of the people have high blood pressure. Furthermore, LDL cholesterol is low in specific gravity and is called bad cholesterol, and is said to be the cause of arteriosclerosis. Conversely, low HDL cholesterolemia is an important risk factor for arteriosclerosis.
That is, it is not a matter of having a low total cholesterol value, but the ratio of HDL and LDL is important. Since HDL has been suggested to remove cholesterol from foam cells and carry it to the liver, this is the main body of anti-atherosclerosis.
HARP-A and HARP-B are the only substances that maintain total cholesterol levels normal and increase HDL cholesterol levels.
This action is mainly due to the synergistic action of the ripened garlic extract and γ-linolenic acid, but further, the antioxidant action of glutathione peroxidase in the ripened garlic extract suppresses the oxidation of LDL and is not recognized by macrophages, so that foam cells are formed. Can be prevented. HARP-A and HARP-B are the only substances that can restore vascular damage due to arteriosclerosis. PGE ₁ produced from γ-linolenic acid has a different mechanism of action from other plastagrandins belonging to other arachidonic acid cascades. PGE ₁ has a strong vasodilatory action, platelet aggregation inhibition, and erythrocyte variability improving action. Vasodilatory effect particularly strong in the arterial system, its vasodilating action is 100 times that of PGI _2. This synergistic effect of PGE ₁ and sodium chondroitin sulfate has the effect of preventing blood clots from flowing through arterial blood vessels to prevent thrombus formation and reducing infarct size. Furthermore, it is possible to repair and restore wounds and tissue damage generated in the blood vessel wall by the synergistic action of all components containing HARP-A and HARP-B.
The arteriosclerosis improving action by HARP-A, HARP-B, or HARP-KK is an epoch-making invention. The reason is as follows.
It has a strong arterial vasodilatory action and further has a blood flow promoting action. It also promotes microvascular blood flow. In particular, it exerts angiogenic effects by continuing exercise. There have been no cases of cerebral infarction or myocardial infarction in the past five years. In addition, it has preventive effects such as late cerebral hemorrhage, which has a blood vessel strengthening action as well as an infarction inhibiting action.註 In general, cerebral infarction drugs tend to cause cerebral hemorrhage. Tissue repair and tissue regeneration are prominent against tissue degeneration in the blood vessel wall. Furthermore, although it takes time to thicken and harden the vessel wall that has already occurred, the objective is achieved by eliminating all risk factors for arteriosclerosis.
1. With regard to blood pressure, it maintains a normal value or less due to a strong arterial vasodilatory effect, and also takes into account the action of ionized calcium factor, and is particularly remarkable in improving the minimum blood pressure.
2. Regarding hyperlipidemia, fat is broken down into fatty acids and glycerol by the action of promoting growth hormone secretion, and further, the action of γ-linolenic acid and aged garlic extract keeps the total cholesterol level to a normal value, The arteriosclerotic state is improved by exerting an increasing action.
3. By increasing blood flow in the coronary, liver, and kidneys, arteriosclerosis is directly and indirectly improved by preventing blood pressure rise, suppressing uric acid, and enhancing detoxification.
4). Prevention of lipid peroxidation due to the antioxidant effect of aged garlic extract greatly contributes to the improvement of arteriosclerosis, but further improves arteriosclerosis by improving glucose tolerance abnormality and exercise therapy with sulfur-containing amino acids.
Even if it takes a long time, there is always a life-threatening human life unless HARP-A or HARP-B, HARPKK as necessary, and dietary therapy are performed to improve arteriosclerosis.
As described above, the three principles of non-disease, health, and vitality are achieved, and this is a necessary and important invention. Regarding brain function. It is the brain that dominates the human body. Aging of the living body progresses with the aging of the brain. On the other hand, if you can achieve rejuvenation and activation of your brain, you can naturally rejuvenate and rejuvenate your body.
Glucose and oxygen are transported to the brain tissue by capillaries, but the amount of budo sugar and oxygen consumed in the brain reaches 20% of the human body. This large amount of oxygen and budoo sugar is involved in the production of ATP, but this ATP is used in the synthesis of hormone transmitters and proteins in brain neurons, but most of it is consumed by the activity of brain neurons. This action also serves the purpose of the arterial vasodilation of PGE ₁ produced from γ-linolenic acid, the action of promoting capillary blood flow by the action of improving erythrocyte variability, and the action of generating sugar in the liver as required. More importantly, PGE ₁ contributes to brain function regulation by generating cyclic AMP from ATP by activation of adenylyl cyclase present in the cell membrane.
Many types of pluteoglucans exist in nerve tissue, and various functions are generated by morphogenesis of brain and nerve tissue. Pluteoglucan is mostly composed of sodium chondroitin sulfate, and is partly composed of protein tissue. Pluteoglucan is involved in neuronal differentiation, migration, and neurite outgrowth. Furthermore, cranial nerve tissue is formed by many unsaturated fatty acids. Antioxidant effect of mature garlic extract by glutathione peroxidase is essential. The brain consists of the cerebrum, cerebellum, and brain stem. The brainstem keeps the functions that are absolutely necessary to live in it, and it controls the functions of the heart and blood vessels, swallowing, sleeping, breathing, defecation and urination. Independent nerves consist of three nervous systems: sympathetic nerves, parasympathetic nerves, and scattered intestinal nerves. The former two work in coordination with each other. The scattered enteric nervous system regulates the function of the gastrointestinal tract. The autonomic nerve is a nervous system that functions autonomously regardless of the will, but the hypothalamus and brainstem are directly related. The rise and fall of blood pressure is due to the sympathetic parasympathetic nerve and is related to the hypothalamus. PGE ₁ produced from γ-linolenic acid has a particularly close relationship with the hypothalamus and directly regulates its action on the autonomic nerve.
As for the brain stem necessary for life support, the synergistic action of PGE ₁ and sodium chondroitin sulfate enables powerful arterial vasodilation, blood flow promoting action, microvascular blood flow promoting side blood flow enhancing action, and blood vessel wall protection Because of its strengthening action, buddo sugar and oxygen are sufficiently replenished, and it is possible to perform a healthy function. The brain stem function is still smoother and more healthy due to the powerful arterial vasodilation of the heart, blood vessels, lungs, kidneys, etc., which is controlled by the brain stem, and the enhancement of the function by promoting blood flow. Configure functions. Further, according to claim 3, healthy nerve cells are differentiated by DNA reformation of neural stem cells, and it is said that these nerve cells decrease by 100,000 daily, but vitamin B ₆ , a mature garlic extract Although it is suppressed to some extent by the synergistic action, the protein synthesis is enhanced by the growth hormone secretion promoting action, and the nerve cell decrease inhibiting action is completed. It is a unique invention. The health and activation of the brain, especially the brain stem, means the health and activation of the human body.
In addition, calcium ionized in HARP-KK has a good absorption rate, exhibits nerve transmission promoting action, is further called a natural tranquilizer, and is strong against stress due to synergistic action with aged garlic extract.
As described above, it has been clarified that the healthy and activated brain function is a source for maintaining or reviving the youth of the human living body and maintaining the vitality. HARP-A or HARP- B, the usefulness of HARP-KK is suggested and this fact is the most significant and important invention. It relates to treatment in the precancerous stage. Pluripotent hematopoietic stem cells present in the bone marrow are divided into myeloid stem cells and lymphoid stem cells. Differentiation of red blood cells, megakaryocytes, platelets, polymorphonuclear leukocytes, and macrophages is induced from myeloid stem cells. In addition, T cells, B cells, and NK cells are induced to differentiate from lymphoid stem cells. Furthermore, T cells mature in the thymus and exert their functions. B cells become mature cells in the bone marrow. Furthermore, T cells and NK cells generated in the small intestinal epithelial tissue are thymus-independent.
When mutant cells are generated in the human body, it is cellular immunity centered on lymphocytes that discriminates and eliminates them by immune responses. Human living stem cells are indispensable for maintaining adults in a normal state and protecting and maintaining them, but they are various depending on their functions and tissue structures. There are various miscellaneous and various types of cancers that are mutant cells. It is natural that normal stem cells are generated from normal stem cells, but when cells divide into two, the DNA present in the cell nucleus is copied, but some external factors or internal This DNA is distorted by factors, and the resulting condition is cancer. It takes about 9 years on average to escape from the network of immune systems centering on cellular immunity and to form a cancer cell population with a diameter of 1 centimeter by the occurrence of a 1-milli diameter cancer cell line. It is said that at this stage, the tissue stem cells for maintaining the homeostasis of the living body have already progressed for a long period of time, so that the DNA denaturation gradually proceeds and the mutant stem cells for generating mutant cells are denatured, An immunosuppressive substance is generated to protect the degenerated self, the balance between the suppressor T cell and the helper T cell is broken, and the immunity of the cancer-bearing adult is greatly reduced, making the treatment difficult. Typical immunosuppressive substances are fetal antigens AFP and CEA, which have special tolerance.
The therapeutic effect of HARP-A and HARP-B is the most correct method that is performed in this previous stage. In addition, although the possibility of detecting Milli cancer is extremely difficult, the early healing induction and preventive effects of HARP-A and HARP-B are accurate and reliable regardless of such matters. 6. The intestinal epithelial tissue according to claim 5, which enhances peristaltic movement of the small intestine by PGE ₁ generated from γ-linolenic acid contained in breast milk in order to protect the newborn body from foreign substances, It exerts a damaging activity against cancer cells by the immune system of small intestine epithelial tissue centering on resident T cells and NK cells. Furthermore, PGE ₁ increases cyclic AMP of various cancer cells, induces differentiation into normal cells, and suppresses their proliferation. It is definitive that cancer can not occur in those who have taken HARP-A or HARP-B and HARP-KK early.
According to claim 3, healthy immune cell differentiation is induced by DNA reform of immune stem cells, and claims 4 and 5 suggest enhancement of intestinal immune function and establishment of defense function against cancer cells.
As described above, the most important matters for achieving the three principles of non-disease, health, and vitality by HARP-A, HARP-B, and HARP-KK are solved. Moreover, this fact for the eradication of cancer with the highest mortality rate for the human body is an epoch-making and important invention. Regarding the occurrence of inflammation. Inflammation can cause symptoms such as rash and swelling as part of a defense response to an immune-related attack on cells and tissues, and in particular increases the permeability of capillaries. Inflammation and immunity are an integral part of the reaction that occurs due to the necessity of facilitating extravasation of leukocytes and the like.
Leukocytes that have migrated outside the blood vessels, especially neutrophils, act on pathogenic bacterial components and tissue-disintegrating components. However, leukocytes infiltrating and accumulating in tissues also have the same effect on antigen-antibody complexes. Eating other substances, digesting with lysosomes present in the cytoplasm, denatures and melts tissue disruption components, and cleans the inflamed area. The tissue and cells in the area become foreign bodies due to bruises and injuries, and the healing period is greatly extended by the leukocyte attack. In addition, when inflammatory exudation is severe, intravascular coagulation and thrombus formation are observed, and infarct necrosis of the tissue occurs. Nuclear cells become the majority of exudate cells. HARP-A and HARP-B are the only substances that have a strong anti-inflammatory effect in the human body and a powerful defense function against foreign body attack. The above describes the inflammatory reaction that should become a constant stone for biological defense, but HARP-A, HARP-B, and HARP-KK exert a function that should be called a common stone for suppressing this inflammatory reaction. For example, biological destruction caused by bruises and injuries is naturally cured in a surprisingly short time. Furthermore, it is possible to prevent type I, type II, type III, and type IV allergy, although the form is different in the previous stage of disease development. However, for diseases caused by antigen-antibody reactions or similar actions, it is impossible to block the action caused by the same antigen. In type I allergy, the IGE antibody binds to the anti-basophil or mast cell surface receptor and specifically binds to the corresponding antigen, causing a change in the higher-order structure. Release granules. Histamine, SRM-A, and the like contained in the granules cause symptoms such as enhanced vascular permeability, smooth muscle contraction, and increased mucus secretion. PGE ₁ produced from γ-linolenic acid activates the action of adenylyl cyclase present in the cytoplasm to increase cycle AMP, thereby suppressing release of histamine, SRM-A and the like from the cell chamber. Vividly alleviates and suppresses type I allergy.
Furthermore, in type III allergic rheumatoid arthritis, IgG-anti-IgG is generated in the joint, and complement is bound to this to release histamine and SRM-A from the cytoplasm, thereby enhancing vascular permeability. Leukocytes to migrate outside the blood vessels. This action is prevented by preventing the release of histamine, SRM-A and the like from the cell chamber by activating adenylyl cyclase present in the cell membrane by PGE ₁ and increasing cyclic AMP.
As described above, HARP-A, or HARP-B and AHARP-KK exert a palliative inhibitory action against allergic inflammation. In addition, when inflammatory exudation is severe, intravascular coagulation, thrombus formation, tissue infarction, and necrosis occur, it exerts a powerful action to repair and regenerate such a state.
The above-mentioned action to prevent inflammation is an essential constitutional improvement compared with other symptomatic treatment agents, and is essential for maintaining the homeostasis of the human body, achieving non-disease, health and vitality Has significant significance. Claims 8 and 11 constitute a novel invention. It relates to autoimmune diseases. Most of the diseases called intractable diseases involve autoimmunity. The ultimate results of long-term research and examination are as follows.
The cause of autoimmune diseases is due to abnormalities in bone marrow stem cells due to internal or external factors. Abnormalities of lympholoin such as interleukin II occur due to abnormalities of T cells generated from bone marrow stem cells, and also results in abnormal functions of B cells and macrophages that are antibody-producing cells.
T cell dysfunction is not due to thymic dysfunction, but is due to the failure of progenitor T cells to differentiate and mature in the thymus. Originally, bone marrow is an important tissue that forms the basis of immunity, and is the only source of stem cells that can revive lymphoid tissue that has become dysfunctional due to radiation or severe illness.
In order for B cells to differentiate and proliferate into antigen-producing cells in response to an antigen, the cooperation of helper T cells is required. Expression of the immune response is regulated by dual control of helper T cells and suppressor T cells. Although it is certain that the cause of the occurrence of various autoimmune diseases is due to abnormal T cells generated by abnormal bone marrow stem cells, all precursor T cells actually generated from the bone marrow are functioning abnormally. If it is demonstrated, the existence of a human living body is impossible.
Bone marrow is present in whole body bones, and its weight is widespread in large tissues reaching a total of over 2000 g. Therefore, regarding the generation of mutant T cells from bone marrow stem cells, it is considered that this is a partial tissue rather than a whole bone marrow tissue. This is thought to significantly affect the treatment of various autoimmune diseases by activating and strengthening the remaining bone marrow function. It has been suggested that a virus such as streptococcus is associated with this bone marrow stem cell failure. Is also an important factor.
HARP-A or HARP-B and HARP-KK possess immunity as described in claims 4 and 5 and have a strong defense against infections such as viruses. Furthermore, claim 3, DNA reformation of immune stem cells is established, and healthy precursor T cells can be differentiated and produced from bone marrow stem cells.
Especially regarding normalization and restoration of bone marrow tissue, HARP-A or HARP-B and HARP-KK are the best strengths. Bone volume enhancement, bone tissue enhancement due to increased bone blood flow, tissue repair, regeneration Reinforcing bone marrow function by strengthening action, normal and healthy progenitor T cells are differentiated from bone marrow stem cells, thereby improving and improving function of spleen, thymus, etc. As long as normalization and restoration of the human immune system is achieved by normalization and restoration of immune cells, as well as preventive effects in the previous stages of autoimmune disease, as long as there is no complete tissue destruction even after the outbreak It is possible to exert a mitigating action.
Although the usefulness of HARP-A, HARP-B, and HARP-KK for autoimmune diseases is clarified as described above, these facts including claims 7 and 8 disclose important inventions. . However, the basic thing is to protect the human body from various tissue destructions caused by various inflammations according to the correct and healthy immune function, the correct immune tolerance, and the correct immune response, and to be more foreign than the less frequently occurring autoimmune diseases. The most important thing is to maintain the homeostasis of the human body by defending the living body from external enemies. It relates to the theory of suppressing aging. Aging is a more powerful extrinsic factor than any disease. It is a methodology to repel this powerful external factor in order to achieve the three principles of non-disease, health and vitality by taking HARP-A or HARP-B and HARP-KK, and to maintain it until the age of 100. The root of 20-year-old freshness is sodium chondroitin sulfate. Sodium chondroitin sulfate is the main component of 60 trillion cell substrates present in the human body, and is the basis for preventing aging and maintaining youthfulness. It eliminates the possibility of causing cerebral infarction and myocardial infarction, which is one of the powerful external factors. The skeleton of the human body is composed of bone tissue and cartilage tissue that supports it. This cartilage is formed mainly of pluteoglucan mainly composed of sodium chondroitin sulfate. HARP-KK-containing component Ionized calcium in oyster shell powder is absorbed by 70-80% in the upper part of the duodenum, and osteoporosis, which is common in aging women, returns to normal bone mass in one year. An aging living body supported by an organization can walk refreshingly, and the aging control theory is established.
The 60 trillion cell capsules present in the human body are easily peroxidized and drowned because they are made of unsaturated fatty acids. Furthermore, since the membrane of the sachet existing in the cells is also an unsaturated fatty acid, it is peroxidized and trapped, and the lysosome flows out from the inside to destroy the self cells. This phenomenon is inhibited by peroxidase of mature garlic extract, and the cells remain normal. When cells are divided, DNA is copied at the time of cell division, but normal cells may not be generated if the nucleic acid is insufficient. Nucleic acids are replenished by the HARP-KK-containing component oyster meat extract to produce normal cells, but in particular PGE ₁ produced from γ-linolenic acid is induced to normal cells by enhancing cyclic AMP. Regeneration and restoration of each tissue is achieved by inducing differentiation of healthy tissue cells by DNA reform of each important tissue stem cell, which is different in dimension from normal cell generation by simple cell division. Can be maintained. This fact establishes the aging control theory.
PGE ₁ produced from γ-linolenic acid enhances arterial vasodilation, promotes blood flow by exposing blood to sodium chondroitin sulfate, and promotes microvascular blood flow by both, thereby activating all other internal tissue functions. Is done. In particular, the brain and heart are the organs that consume the most sugar oxygen, and both occupy 50% or more of the anterior visceral tissue. The brain and heart are the organs that control the human body, and by activation, the three principles of non-disease, health, and vitality are inevitably achieved.
It should be noted that sugar and oxygen should be adequately replenished by promoting arterial blood flow, but in the case of diabetic patients, the membrane permeation of sugar may not be performed normally, which may cause problems. In some cases, insulin secretion decreases and the same condition appears, complaining of wobbling of the head, shortness of breath of the heart, and the like.
This problem is solved by sulfur-containing amino acids contained in the aged garlic extract. In this case, light and continuous exercise is most effective. Furthermore, by strengthening exercise, tissue regeneration and microangiogenesis action are expressed by the synergistic action of all components of HARP-A, HARP-B, and HARP-KK, and biological function enhancement is established. Furthermore, by strengthening exercise and increasing protein intake, the secretion of growth hormone with strong affinity with PGE ₁ produced from γ-linolenic acid is promoted, and the rejuvenation and vitalization of the living body are reversed against the progress of aging. Once achieved, the aging control theory is established.
The eyes are said to be a mirror of the internal organs, and clear eyes mean that the internal organs are healthy. Except for elderly cataracts and diabetic retinopathy, the recovery of visual acuity has achieved more than 90% with the action of chondroitin sulfate sodium and aged garlic extract. In oriental medicine, the relationship between eyes and liver has been suggested, but PGE ₁ produced from γ-linolenic acid promotes arterial blood flow and enhances liver function by promoting bile secretion, chondroitin sulfate sodium, and mature garlic extract. The liver function is improved by the liver cell function improving action.
As a unique action, the sulfur-containing amino acid in the aging garlic extract component finally produces taurine, and when this taurine is used continuously, gallstones naturally disappear, and the synergistic action of γ-linolenic acid and placenta extract results in C-type. Confirm that it has been proved that the increase in GOT and GPT in hepatitis is improved to normal values.
The aging control theory is established by the above. With the establishment of the theory of aging suppression, the achievement of non-disease, health and vitality objectives is established, and it is possible to challenge to maintain this until the age of 100.
The above facts are comprehensively important and important inventions.