JP2008260726A - Oral composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an oral composition having an abrasive material being dispersed uniformly and exhibiting a high cleaning effect with a low abrasive power. <P>SOLUTION: This oral composition comprises a cellulose-compounded material comprising crystalline cellulose, polysaccharide and/or its derivative (which is obtained by kneading/grinding insoluble crystalline cellulose obtained by the chemical treatment such as the acid hydrolysis or alkaline oxidative decomposition of cellulosic raw materials such as cotton linter, pulp, regenerated fibers, etc., a polysaccharide and/or its derivatives, drying, then crushing and sieving as it is) and an abrasive material. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to an oral composition containing a cellulose composite, and is used as a toothpaste that can uniformly disperse an abrasive and impart a high cleaning effect with low polishing power.

  2. Description of the Related Art Conventionally, it has been known that the cleaning effect of a composition for oral cavity is enhanced by using a polishing agent such as an inorganic powder or an organic powder to increase the effect of removing stains that cause coloring of teeth. Since the cleaning effect is proportional to the polishing power of the abrasive, it is necessary to increase the blending amount of the abrasive or use a strong abrasive to enhance the cleaning effect. However, while the cleaning effect is enhanced, the dentin of the teeth is shaved and there is a risk of causing unnecessary damage. Therefore, it has been desired to develop an oral composition having a low cleaning power and a high cleaning effect.

  About the composition for oral cavity which mix | blends a cellulose, it is disclosed by patent document 1 and patent document 2 until now. Patent Document 1 proposes that a micronized cellulose material is blended in a dentifrice composition, and has an extrudability and a shape retention property, and is excellent in a mouth-feeling property. However, it does not describe the polishing effect or the cleaning effect. When the polishing effect and cleaning effect of the composition were examined, the cleaning effect was sufficient, but when a large amount of abrasive was used, the polishing effect became too strong due to a synergistic effect, and there was a tendency to scrape dentin more than necessary. there were.

Patent Document 2 proposes a cellulose composite composed of fine cellulose and a polyhydric alcohol. However, in the production of an oral composition, this cellulose composite uses a cellulose composite powder instead of supplying a fine cellulose aqueous dispersion as a raw material, and improves the production efficiency by supplying cellulose as a powder. It was improved and did not increase the cleaning effect of the abrasive.
Japanese Patent Laid-Open No. 5-58861 JP 2003-95904 A

  The present invention relates to an oral composition containing a cellulose composite, and provides an oral composition in which an abrasive is uniformly dispersed and can provide a high cleaning effect with low polishing power. is there.

As a result of intensive studies to solve the above problems, the present inventors have solved the problem by using a cellulose composite composed of crystalline cellulose and polysaccharides and / or derivatives thereof. That is, the invention is as follows.
(1) An oral composition comprising a cellulose composite and an abrasive obtained by mixing crystalline cellulose and polysaccharides and / or derivatives thereof.
(2) The composition for oral cavity according to (1), wherein the content of the crystalline cellulose fine powder is less than 10% by mass.

(3) The composition for oral cavity according to (1) or (2), wherein the polysaccharide and / or derivative thereof is carboxymethylcellulose.

  Even if the cellulose composite in the present invention is dispersed in water at a high concentration, it can be uniformly dispersed and the abrasive can be uniformly dispersed. Therefore, the oral composition of the present invention formulated with this has high cleaning with low polishing power. The effect is exhibited and the extrudability is also good.

Hereinafter, the present invention will be described in detail.
Crystalline cellulose used in the present invention is obtained by acid hydrolysis or alkali oxidation decomposition of natural cellulose materials produced by microorganisms such as pulp, linter, regenerated fiber, and acetic acid bacteria obtained from wood and annual grass. This refers to a polymer having a degree of polymerization of about 30 to 375, for example, as described in JP-B-40-6118.

  The polysaccharide and / or derivative thereof used in the present invention is preferably water-soluble and may be generally used. Preferably, the substituent includes an ether bond of cellulose, and metal salts such as carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxyethylmethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose and derivatives thereof such as sodium carboxymethylcellulose and sodium Can be mentioned. Examples of those not containing an ester bond of cellulose include xanthan gum, karaya gum, gum arabic, locust bean gum, guar gum, tarragant gum, psyllium seed gum, tamarind seed gum, alginic acid, pectin and derivatives thereof. Among these, carboxymethylcellulose sodium is particularly preferable. As sodium carboxymethylcellulose, those having a carboxymethyl group substitution degree of 0.2 to 1.5, a polymerization degree of 200 to 500, and a 2 wt% aqueous solution with a viscosity of about 10 to 1000 mPa · s are preferable. The polysaccharide and / or derivative thereof in the cellulose composite is dispersed in water and serves as a protective colloid for the cellulose particles, thereby preventing the aggregation and sedimentation thereof. Furthermore, dextrins such as hydrolyzed starch, xylose, glucose, fructose, arabinose, galactose, mannose, fucose, raffinose, planteose, trehalose, xylo-oligo for the purpose of promoting the dispersion of cellulose particles in water and adjusting the flavor. Sugars, cellooligosaccharides, fructooligosaccharides, isomaltooligosaccharides, arabino-oligosaccharides, galactooligosaccharides, and other sugars, sucrose fatty acid esters, glycerin fatty acid esters, lecithin and other emulsifiers, and oils and fats such as linoleic acid, linolenic acid and oleic acid It is free to mix.

The cellulose composite of the present invention can be obtained by kneading and grinding the crystalline cellulose and the polysaccharide and / or derivative thereof, followed by drying, pulverization or sieving. The mixing ratio of crystalline cellulose and polysaccharide and / or derivative thereof is preferably 50 to 95% by mass of crystalline cellulose, and 50 to 5% by mass of polysaccharide and / or derivative thereof, particularly preferably crystalline cellulose. Is 75 to 90% by mass, and polysaccharide and / or derivative thereof is 25 to 10% by mass. If the crystalline cellulose is less than 50% by mass, the holding effect of the abrasive is weak, sufficient dispersion stability cannot be obtained, and it is difficult to obtain uniformity. When the polysaccharide and / or derivative thereof is less than 5% by weight, the redispersibility of cellulose particles is deteriorated, and the effects of the present invention may not be obtained.
The kneading and grinding of the crystalline cellulose and the polysaccharide and / or derivative thereof is performed by, for example, a kneader, a planetary mixer, a likai machine, an extruder, a three-roll, a colloid mill, etc., and the next drying is a drum drying method, Conventional methods such as a shelf-type drying method, a belt drying method, a spray drying method, and a vacuum drying method may be used. The pulverization can be performed by a general pulverization method such as a hammer mill, a turbo mill, a fine mill, a jet mill, a bantam mill, a grinder mill, or a cutter mill.

  The cellulose composite in the present invention can be blended in water by a known method such as mechanical dispersion using a homogenizer or the like. When the cellulose composite is dispersed in water, the average particle size of the cellulose particles is 20 μm or less, preferably 10 μm or less, more preferably 5 μm or less. When the average particle diameter exceeds 20 μm, it may give a rough surface or a feeling of foreign matter, or may deteriorate the stability of the dispersion. Although there is no restriction | limiting in particular in a lower limit, It is preferable to mix | blend the cellulose composite used for this invention in an oral composition from 1 mass% or more and less than 10 mass%. More preferably, it is 3 mass% or more and less than 10 mass%. When the amount is less than 1% by mass, sufficient dispersion stability is not exhibited, and the abrasive composition of the oral composition is often separated and settled. If it is 3% by mass or more, dispersion stability can be obtained in most cases. When it exceeds 10 mass%, the whole composition for oral cavity will gelatinize, a base material will not disperse | distribute uniformly and it will become easy to raise | generate segregation.

The crystalline cellulose fine powder referred to in the present invention is crystalline cellulose to be blended in the oral composition in addition to the crystalline cellulose as a component of the cellulose composite, and has an average particle size of 10 μm or less. Say.
The content of the crystalline cellulose fine powder in the oral composition is preferably less than 10% by mass, more preferably less than 4% by mass, still more preferably less than 2% by mass, and most preferably less than 0.2% by mass. Crystalline cellulose itself has high cleanability and low polishing. However, when a large amount of other abrasives are present, the polishing effect may be too high or the viscosity may be high. In the case of a general abrasive content, if the crystalline cellulose exceeds 10% by mass, the polishing effect becomes too high and the dentin may be scraped more than necessary.

  Examples of the abrasive that can be blended in the composition of the present invention include abrasive silica such as abrasive precipitated silica and abrasive gel silica, calcium hydrogenphosphate dihydrate and anhydrous, calcium phosphate, tricalcium phosphate, carbonate Calcium, calcium pyrophosphate, calcium silicate, aluminum hydroxide, aluminum oxide, aluminum silicate, pumice (pumice), insoluble sodium metaphosphate, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, magnesium sulfate, polymethyl methacrylate, Examples include bentonite, zirconium silicate, hydroxyapatite, synthetic resin, titanium oxide, and zeolite. Abrasive silica, calcium hydrogen phosphate dihydrate and anhydrous, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, aluminum oxide, and hydroxyapatite are preferable. Abrasive silica, calcium hydrogen phosphate dihydrate and anhydrous, and aluminum oxide are more preferable, and abrasive silica is most preferable. An abrasive | polishing agent may be used individually by 1 type, and may use 2 or more types together. The amount of the abrasive added is appropriately adjusted depending on the amount used, but is preferably 5% by mass to 60% by mass, more preferably 10% by mass to 50% by mass, and still more preferably based on the entire composition. It is 10 mass%-40 mass%.

In the composition of the present invention, a binder, an oil and fat component, a surfactant, a sweetener, a fragrance, a stabilizer, a medicinal component, a pH adjuster, or the like can be used alone or in combination of two or more as necessary. .
Examples of the binder include methylcellulose, hydroxypropylcellulose, sodium carboxymethylcellulose, hydroxyethylcellulose, propylene glycol alginate, pullulan, tragacanth gum, xanthan gum, pectin, fercelan, chitosan, polyethylene oxide, polyvinylpyrrolidone, polyacrylic acid and polymethacrylic acid. Or these salts, gelatin, peptone, casein, collagen, albumin, carrageenan, gum arabic, karaya gum, carboxyvinyl polymer, Eudragit, ethyl cellulose, cellulose acetate, sodium polyacrylate, polyvinyl alcohol, polyvinyl acetal dimethylamino acetate, cellulose acetate・ Dibutyl hydroxypropi It may be used ether.

Examples of the oil and fat component include higher alcohols such as liquid paraffin, paraffin, cetyl alcohol, and stearyl alcohol, and fatty acid esters such as oleic acid and isopropyl myristate.
As alcohols, lower alcohols such as ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, 1,5-pentadiol, sorbit And polyhydric alcohols such as polyethylene glycol.

  Surfactants include non-ionic surfactants such as sorbitan fatty acid ester, glycerin fatty acid ester, decaglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol / pentaerythritol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycerin. Fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene glycol, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl ether , Polyoxyethylene castor oil / hardened castor oil, polyoxyethylene Norin, lanolin alcohol, beeswax derivative, polyoxyethylene alkylamine, fatty acid amide, polyoxyethylene alkylphenyl formaldehyde condensate, single chain length polyoxyethylene alkyl ether, anionic surfactants include sodium lauryl sulfate, myristyl sulfate Sodium, alkyl sulfate, polyoxyethylene alkyl sulfate, N-acyl amino acid and its salt, N-acylmethyl taurine and its salt, polyoxyethylene alkyl ether acetate, alkyl sulfocarboxylate, α-olefin sulfonate Alkyl phosphates, polyoxyethylene alkyl ether phosphates, cationic surfactants include alkyl ammonium, alkyl benzyl ammonium salts, and amphoteric surfactants include solid acetate. Examples of in, imidazolinium betaine, lecithin, and nonionic surfactants include sucrose fatty acid esters and decaglyceryl laurate.

  Examples of the sweetener include saccharin sodium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, asparatylphenylalanine methyl ester, acesulfame potassium, perilartin, p-methoxycinnamamic aldehyde, aspartame, xylitol and the like.

Examples of the fragrances include essential oils such as peppermint and spearmint, eucalyptus oil, orange oil, lemon oil, l-menthol, carvone, eugenol, anethole and herb mint.
Examples of the stabilizer include vitamin C, vitamin E and derivatives thereof, sodium sulfite, sodium pyrosulfite, sodium hydrogen sulfite, butylhydroxytoluene, butylhydroxyanisole and the like.

  Medicinal components include antibacterial agents such as chlorhexidine, triclosan, cetylpyridinium chloride and hinokitiol, fluorine compounds such as sodium fluoride, stannous fluoride and sodium monofluorophosphate, plaque such as dextranase, mutanase and protease. Formation inhibitor, tranexamic acid, aminocaproic acid, glycyrrhizic acid, glycyrrhetinic acid, azulene, allantoin, lysozyme chloride, psyllium extract and other gingivitis preventives, polyphosphates and other anticalculus agents, sodium chloride and other gum tightening agents, tocopherol acetate, etc. And various vitamins.

Examples of pH adjusters include citric acid and its salts, phosphoric acid and its salts, malic acid and its salts, gluconic acid and its salts, maleic acid and its salts, aspartic acid and its salts, gluconic acid and its salts, succinic acid And salts thereof, glucuronic acid and salts thereof, fumaric acid and salts thereof, glutamic acid and salts thereof, adipic acid and salts thereof, hydrochloric acid, hydrofluoric acid, alkali metal hydroxide and the like.
The cellulose composite of the present invention can be used as a toothpaste because it can impart high viscosity and thixotropy when blended with an oral composition, and can improve separation of abrasives, reduction of sedimentation, extrusion from a tube, and shape loss. .

  EXAMPLES Next, although an Example demonstrates this invention further in detail, these do not restrict | limit the scope of the present invention. In addition, the average particle diameter of the cellulose powder, the polishing power of the toothpaste, the cleaning power, the abrasive uniformity, and the extrudability in the examples and comparative examples were measured and evaluated as follows.

<Average particle size>
Using a laser diffraction / scattering apparatus, the value at which the integrated volume reached 50% was read and taken as the average particle size.
<Polishing power measurement method>
RDA value, which is the dentin polishing value, was measured by the general RDA method described in Journal of Dental Research., Vol. 55, vol 4, p.563-573, 1976, which measures the degree of dentin polishing. . A smaller RDA value indicates a lower abrasiveness.
[Evaluation criteria]
◎ ・ ・ ・ RDA value is less than 100 ○ ・ ・ ・ RDA value is 100 or more and less than 150 △ ・ ・ ・ RDA value is 150 or more and less than 200 × ・ ・ ・ RDA value is 200 or more

<Cleaning power evaluation method>
After applying the paint taken out from the tobacco in advance on the acrylic plate, heating and drying it, fixing it to a commercially available abrasiveness tester, and using a solution in which 10 g of toothpaste is dispersed in 20 g of ion-exchanged water, brushing load Artificial brushing was performed at 300 g, brushing frequency of 100 strokes, and stroke width of 10 cm. After brushing, sensory evaluation was performed by visually observing the removal of spider on the acrylic plate. The results are shown in Table 2.
[Evaluation criteria]
A: The ratio of removal of spears is 80% or more.
O ... The percentage of removal of the spider is 50% or more and less than 80%.
Δ: The ratio of removal of spear is 30% or more and less than 50%.
X: The ratio of removal of spider is less than 30%.

<Evaluation of abrasive uniformity>
A small amount of sample was placed on a slide glass and observed with a cover glass. The state of dispersion of the abrasive was evaluated by observation with an optical microscope.
"Evaluation criteria"
A ... The abrasive is completely uniformly dispersed.
○: The abrasive is almost dispersed.
Δ: The abrasive is slightly dispersed.
X: The abrasive is not dispersed at all.

<Extrudability evaluation>
The trial toothpaste was filled in a toothpaste tube, and the exfoliated surface and the shape of the mold were observed when extruded from the tube.
"Evaluation criteria"
◎ ... Does not cause mold deformation during extrusion and does not cause water separation on the surface.
○ ・ ・ ・ No deformation of the mold during extrusion, but a little water separation occurs on the surface.
Δ: Slightly deformed during extrusion, causing water separation on the surface.
X: The mold is completely deformed during extrusion and water separation occurs on the surface.
[Example 1]

(1) Preparation of cellulose composite consisting of crystalline cellulose and sodium carboxymethyl cellulose Cut commercially available DP pulp (average polymerization degree 850), obtained by hydrolyzing at 105 ° C. for 30 minutes under 1% hydrochloric acid. The acid-insoluble residue was filtered and washed with pure water to obtain a wet cake. Sodium carboxymethylcellulose was added so that the cellulose / carboxymethylcellulose sodium ratio was 89/11 (solid content mass ratio) with respect to the solid content of the water-insoluble cellulose, and kneading and grinding were performed with a kneader. . Next, it was dried with hot air and pulverized with a hammer mill to obtain a cellulose composite powder A as a dry powder composed of crystalline cellulose and sodium carboxymethylcellulose. The average particle size of this dry powder was 8.0 μm.
(2) Preparation and Evaluation of Toothpaste Using the cellulose composite powder A obtained above, an oral composition was produced according to the following formulation.

Calcium hydrogen phosphate dihydrate 30% by mass
Glycerin 5% by mass
Sodium lauryl sulfate 2% by mass
Saccharin sodium 0.2% by mass
Fragrance 1% by mass
Cellulose composite powder A 3% by mass
Purified water 58.8% by mass
Next, the obtained toothpaste was evaluated for polishing power, cleaning power, abrasive uniformity and extrudability. The evaluation results are shown in Table 1.

[Comparative Example 1]
Commercially available DP pulp is cut and hydrolyzed in a 10% aqueous hydrochloric acid solution at 105 ° C. for 30 minutes. The insoluble residue obtained is filtered, washed, and pH adjusted to obtain a cellulose dispersion having a solid content of 14% and pH 6.5. I adjusted my body. The cellulose dispersion was spray-dried and jet milled to obtain crystalline cellulose powder A (crystalline cellulose fine powder). The obtained crystalline cellulose powder A had an average particle size of 9 microns. Next, the toothpaste of Comparative Example 1 was produced in the same manner as in Example 1 except that the crystalline cellulose powder A was used in place of the cellulose composite powder A.
The evaluation results are shown in Table 1.

[Comparative Example 2]
In Example 1, the toothpaste of Comparative Example 2 was produced in the same manner as in Example 1 except that sodium carboxymethylcellulose was used in place of the cellulose composite powder A.
The evaluation results are shown in Table 1.
[Comparative Example 3]
Comparative Example 3 was carried out in the same manner as in Example 1 except that the cellulose composite powder A was reduced to 1% by mass, the crystalline cellulose powder A was added by 10% by mass, and the water was reduced by the increment in Example 1. An intraoral composition was prepared. The evaluation results are shown in Table 1.

<Evaluation results>
In Example 1, although the RDA value showed a low value of less than 100, a high cleaning effect was recognized. Furthermore, it was confirmed that the abrasive in the toothpaste composition was uniformly dispersed, and the extrudability from the tube did not cause water separation on the surface of the toothpaste composition, and did not lose its shape. . On the other hand, although the comparative example 1 mix | blends crystalline cellulose powder, it did not come to exhibit the high cleaning effect with low polishing power like the cellulose composite of an Example. Further, since the dispersibility of the crystalline cellulose powder itself was poor, the abrasive could not be uniformly dispersed, segregation occurred in part, and water separation was observed on the surface of the extruded toothpaste composition. Further, Comparative Example 2 contains carboxymethyl cellulose, which is a water-soluble cellulose, but is water-soluble, has low polishing power and a low cleaning effect, and has high dispersibility at high viscosity. The agent could not be uniformly dispersed. In Comparative Example 3, the crystalline cellulose powder A, which is a crystalline cellulose fine powder, was added in addition to the cellulose composite, so that the polishing power was somewhat strong. In addition, the uniformity of the abrasive and the extrudability were also higher than in Example 1. Slightly inferior. It can be said that it is better to add crystalline cellulose as a composite as in the present invention.

  The composition for oral cavity comprising the cellulose composite of the present invention as a component is suitable as a toothpaste and the like because it exhibits a high cleaning effect with low polishing power and good extrudability because the abrasive is uniformly dispersed. Can be used for

Claims (3)

  An oral composition comprising a cellulose composite and an abrasive obtained by mixing crystalline cellulose and a polysaccharide and / or a derivative thereof.   The composition for oral cavity according to claim 1, wherein the content of the crystalline cellulose fine powder is less than 10% by mass.   The composition for oral cavity according to claim 1 or 2, wherein the polysaccharide and / or derivative thereof is carboxymethylcellulose.