JP2008259518A - Fluid transporting device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a fluid transplanting device that realizes the downsizing and thinning and can be equipped in vivo. <P>SOLUTION: The fluid transporting device 1 is for allowing fluid to flow continuously by pressing tube 50 and has a fluid transporting mechanism 2 having the first cum 20 for pressing the fingers 40 to 46 in order to block the tube 50 and the second com 30, a driving power transmitting mechanism 3 that transmits the driving power to the fluid transposition mechanism 2, a reserver 60 connecting to the tube 50, a valve (port) 80 for filling the fluid into the reserver 60, and a cell 4 for feeding electric power to the drive power emitting mechanism 3 wherein the fluid transporting apparatus 2 and the driving power emitting mechanism 3 are arranged so that they may be overlapped, and the fluid transplanting mechanism 2 and the reserver 60 is arranged on the position so that it may not overlapped to the liquid transplanting mechanism and the drive power transmitting mechanism 3. Finally, at least the fluid transplanting mechanism 2, the drive power transmitting mechanism 3, and the cell 4 are housed in the sealed space formed with the outer case made of the upper lid 13 (Fig.1) and the lower lid 16 (Fig.1). <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a fluid transport device that presses a tube to flow a fluid, and more specifically, uses a drive transmission mechanism of a watch movement as a fluid transport mechanism, and superimposes the fluid transport mechanism and the drive transmission mechanism, The present invention relates to a structure of a fluid transportation device in which these mechanisms are arranged in a planar manner and these mechanisms are hermetically stored inside a casing. The present invention also relates to a structure of a fluid transport device that is implanted under the skin of a laboratory animal or the like and supplies a chemical solution into the body.

2. Description of the Related Art Conventionally, as a small fluid transporting device (pump) that can be carried close to a human body, a pump module provided with a coupling element, an output gear mechanism provided with a power take-out unit coupled to the coupling element, and the output gear mechanism are driven. The motor module includes a step motor, a control circuit, and a battery. The pump module and the motor module can be assembled and disassembled with each other, the connecting element is a gear, and the power take-out part is a pinion. A fluid transport device is known (see, for example, Patent Document 1).
Conventionally, experiments have been conducted to verify the efficacy of chemicals using small animals such as mice and guinea pigs, and various chemical supply devices (fluid transport devices) for supplying chemicals to small animals have been proposed. ing.
Among them, a type has been proposed in which a harness is attached to a mouse of an experimental animal, and a catheter supported by the harness is passed through the skin of the experimental animal to continuously supply a chemical solution (Patent Document 2).
On the other hand, a type in which a chemical solution supply device (fluid transport device) is embedded in the body of a laboratory animal has been proposed (see Non-Patent Document 1). This type is to be implanted under the skin of a laboratory animal. By injecting a special needle into the drug supply device from the outside and injecting the drug solution, the drug solution is injected into the body of the experimental animal through a catheter. is there.
On the other hand, an artificial pancreas device that is implanted in a human body and supplies insulin to a patient has also been proposed (see Patent Document 3). As shown in FIG. 1, this artificial pancreas device includes a rechargeable battery as a power source, an insulin reservoir for storing insulin, a micropump for feeding insulin into the abdominal cavity, and the like, and is implanted in a patient. For example, once a month, one month of insulin is percutaneously punctured to replenish the reservoir.

Japanese Patent No. 3177742 (pages 5, 6 and 1) Japanese Utility Model Publication No. 5-74511 JP 2001-286555 A Bio-Research Center Co., Ltd. animal experiment equipment catalog (subcutaneous implantable access port for small animals)

In Patent Document 1, the pump module and the motor module have a structure that can be connected to and disconnected from each other, and this connection and disconnection work can be performed by doctors and nurses. In a structure capable of performing work, it is difficult to ensure waterproofness between the pump module and the motor module, and it cannot be mounted in the living body.
The motor module and the pump module are connected by meshing a pinion provided on the motor module side with a gear provided on the pump module side. Assembling with the pinion and gear engaged in this way is usually expected to significantly reduce workability because the phase of the pinion and gear is out of phase, and to easily damage the pinion and gear. In the case of low torque driving by the step motor, there is a risk that the driving may be hindered.
In addition, the reservoir for storing the drug and the pump body are provided apart from each other and are connected by a tube. However, if the pump body is mounted in the living body, the inside and outside of the living body are communicated by the tube. Therefore, there is a risk that infectious diseases and the like are likely to occur in this communication part.
Further, when the drug is added and driven, the reservoir must be replaced, and it is considered that continuous injection of the drug is stopped.

Moreover, in the type of the above-mentioned Patent Document 2, since the chemical solution supply unit is outside the experimental animal, when the experimental animal moves around, the chemical solution supply unit easily moves from the experimental animal, and the risk that the catheter is detached from the experimental animal. Have Further, since the catheter is inserted into the experimental animal, there is a high possibility that the skin of the inserted portion will be inflamed.
Since the type of Non-Patent Document 1 does not include a micropump that supplies a chemical solution from the chemical solution supply device to the body of the experimental animal, it is basically an external dedicated needle that supplies the chemical solution to the body of the experimental animal. Depends on the supply capacity of chemicals from Therefore, the chemical solution cannot be continuously and quantitatively supplied to the laboratory animal.
The type of the above-mentioned Patent Document 3 is for implanting a device for supplying insulin into a patient's body, but since the catheter is placed in the abdominal cavity, the artificial pancreas itself is expected to be implanted in the vicinity of the abdominal cavity. Therefore, it is considered that the artificial pancreas is relatively large or thick because it is not required to be as small and thin as the type implanted under the skin. Further, no specific disclosure has been made regarding how to arrange the above-mentioned rechargeable battery, insulin reservoir, micropump, catheter and the like in the artificial pancreas.
Further, in each of the above-mentioned patent documents and non-patent document 1, consideration is not given to the outer shape to reduce as much as possible the occurrence of a sense of incongruity in the animal when implanted under the skin of the animal.

The object of the present invention is to solve the above-described problems, and achieve miniaturization and thinning, and additional injection of fluid into a reservoir can be performed at an arbitrary timing, and a small amount of fluid can be continuously supplied. It is an object of the present invention to provide a fluid transport device that can flow continuously and has high safety.
It is another object of the present invention to provide a fluid transport device capable of continuously and stably supplying a chemical solution (fluid) when used under the skin of an animal or the like.
It is another object of the present invention to provide a fluid transport device that reliably supplies chemical liquid (fluid) to the reservoir from the outside.
It is another object of the present invention to provide a fluid transporting device having an outer shape that reduces as much as possible an uncomfortable feeling to an animal or the like when it is implanted under the skin of an animal or the like (including after being implanted).

The fluid transport device according to Embodiment 1 of the present invention is a small fluid transport device that continuously squeezes fluid by squeezing an elastic tube, and includes a plurality of fingers that close the tube, and the plurality of fingers. A fluid transport mechanism having a cam that sequentially presses the fluid from the inflow side to the outflow side; a drive transmission mechanism that transmits a driving force to the fluid transport mechanism; a reservoir that contains fluid that communicates with the inflow side of the tube; and the reservoir A fluid injection port and a power source for supplying electric power to the drive transmission mechanism, wherein the fluid transport mechanism and the drive transmission mechanism are arranged to overlap, and the fluid transport mechanism and the drive transmission mechanism An exterior in which the reservoir is disposed at a position where it does not overlap, and at least the fluid transport mechanism, the drive transmission mechanism, and the power source are constituted by an upper lid and a lower lid Characterized in that it is stored in the enclosed space over scan.
Here, as the power source, for example, a button-type small battery used in a watch or the like can be employed.
According to this invention, since at least all of the components such as the fluid transport mechanism, the drive transmission mechanism, the battery, and the port are hermetically stored in the outer case, moisture, dust, etc. can enter the outer case. It can be used in living bodies, fluids, and dusty environments.
In addition, when the fluid transportation device of the present invention is installed in a living body, since there are no components protruding outside the living body including a tube, there is no occurrence of infectious diseases at the connection part between the inside and outside of the living body, It can be used safely.
In addition, since the reservoir is provided with a port for injecting fluid, the fluid can be additionally injected at an arbitrary timing even while the fluid transport device is being driven. Therefore, the drive is stopped by the additional injection of fluid. The continuous flow of the fluid can be continued without any problems.
Further, by arranging the fluid transport mechanism, the drive transmission mechanism, the battery, the reservoir, and the port as described above, a reduction in size and thickness can be realized.

The fluid transport device according to Embodiment 2 of the present invention is the fluid transport device according to Embodiment 1 of the present invention, wherein the reservoir is stored in a sealed space of the outer case.
According to the present invention, since the reservoir is also hermetically stored in the outer case, moisture, dust and the like do not enter the outer case and can be protected from the external environment including the reservoir.
In addition, the fluid transport device according to Embodiment 3 of the present invention is the fluid transport device according to Embodiment 1 of the present invention, wherein the reservoir is held outside the outer case in a state inclined with respect to the surface. And
According to the present invention, since the reservoir is attached to the outside of the exterior case, even when condensation occurs on the surface of the reservoir, the influence on the drive transmission mechanism and the battery can be avoided, and the occurrence of rust and circuit malfunction are suppressed By doing so, it becomes possible to improve durability.
Furthermore, since the reservoir is held in an inclined state on the surface of the exterior case, for example, when this fluid transport device is implanted subcutaneously, it becomes possible to prevent the skin from being stretched at the end of the reservoir, It is possible to reduce the uncomfortable feeling after installation.
Further, the fluid transport device according to Embodiment 4 of the present invention is the fluid transport device according to Embodiment 1 or Embodiment 3 of the present invention, wherein the reservoir is detachable from the outer case through a reservoir frame. It is attached.
According to this invention, since the reservoir is attached in a detachable state via the reservoir frame, the reservoir can be reliably held at a predetermined position of the outer case, and workability such as replacement can be improved. Become.
Furthermore, when this fluid transport device is implanted subcutaneously, the lower side of the reservoir protects the living body with a hard reservoir frame, and the upper side is opened, so that the reservoir can be easily deformed.

Moreover, the fluid transport apparatus according to Embodiment 5 of the present invention is the fluid transport apparatus according to any one of Embodiments 1 to 4 of the present invention, wherein the drive transmission mechanism includes a step motor and a train wheel. The cam is inserted into the shaft portion of the hour wheel of the wheel train that is composed of a watch movement and protrudes in the direction of the fluid transport mechanism.
Here, the train wheel is a generic term for a plurality of gears that transmit the rotation of the step motor to the cam.
As described above, since the drive transmission mechanism is constituted by a watch movement, the drive transmission mechanism can be reduced in size and thickness, and thus the fluid transport device can be reduced in size and thickness. In addition, the watch movement, which is mass-produced including the hour wheel to which the cam is inserted, is adopted, which contributes to cost reduction.

The fluid transport device according to Embodiment 6 of the present invention is the fluid transport device according to any one of Embodiments 1 to 5 of the present invention, wherein the port is disposed through the upper lid. It is characterized by.
By doing so, when the fluid is injected from the port into the reservoir, there is no member that hinders the injection operation above the port, so that the injection operation can be easily performed.

In addition, the fluid transport device according to Embodiment 7 of the present invention is the fluid transport device according to any one of Embodiments 1 to 6 of the present invention, wherein the fluid inflow port communicates with the tube provided in the reservoir. And a fluid inlet port communicating with the port are arranged at positions separated from each other so that fluid flows inside the reservoir.
The fluid in the reservoir flows from the fluid inlet port communicating with the port toward the fluid inlet port communicating with the tube. Therefore, by arranging the fluid inlet port on the upstream side and the fluid inlet port on the downstream side, it is possible to suppress the occurrence of fluid vortex and pulsation in the reservoir. A stable continuous flow can be maintained.

In addition, the fluid transport device according to Embodiment 8 of the present invention is the fluid transport device according to any one of Embodiments 1 to 7 of the present invention, wherein the reservoir is formed of a deformable wrapping bag. It is characterized by being.
Since the reservoir is stored in a sealed space of the outer case made up of the upper lid and the lower lid, when the fluid flows and is discharged by the fluid transport mechanism, the pressure in the reservoir decreases. Therefore, by configuring the reservoir with a deformable wrapping bag, the pressure in the reservoir can be kept substantially constant by being deformed so that the volume of the reservoir is reduced as the internal pressure decreases. Accordingly, when the tube is closed with the fingers and then opened, the fluid flows into the opened tube, so that a stable fluid flow can be maintained.

A fluid transportation device according to Embodiment 9 of the present invention is the fluid transportation device according to any one of Embodiments 1 to 8 of the present invention, wherein the flat surface of the outer case comprising the upper lid and the lower lid. The shape is an oval shape, and the outer periphery is formed into a gentle streamline shape.
By making the outer shape of the fluid transport device in this way, when this fluid transport device is mounted in the living body, the biocompatibility between the living tissue and the outer case is improved, and the outer case damages the living tissue, A sense of incongruity due to wearing can be suppressed.

In addition, the fluid transport device according to Embodiment 10 of the present invention is the fluid transport device according to any one of Embodiments 1 to 9 of the present invention, wherein the fluid outflow side end of the tube has the upper lid. It extends along the outer peripheral part shape of this.
Although the details will be described in an embodiment described later, the fluid outflow side end of the tube protrudes outside the outer case, but the tube outflow end is formed in a gentle streamline shape. Since the tube extends along the part, the biocompatibility between the tube and the living tissue is good, and the tube can damage the living tissue or suppress discomfort caused by mounting.

In addition, the fluid transport device according to Embodiment 11 of the present invention is the fluid transport device according to any one of Embodiments 1 to 10 of the present invention, wherein the fluid injection plug provided in the port has elasticity. The injection needle-like injection needle is inserted to inject fluid into the reservoir, and when the injection needle is removed, the portion where the injection needle is inserted is the elasticity of the fluid injection plug itself. It is sealed with.
Therefore, when the injection needle is inserted into the above-described fluid injection stopper, the fluid is injected into the fluid container, and then the injection needle is removed, the portion where the injection needle is inserted is blocked by the elastic force of the fluid injection stopper itself. In addition, the fluid can be prevented from flowing out from the port. Such a port can be realized with a simple structure without using a valve or the like, and the fluid injection operation can be repeated.

The fluid transport device according to the twelfth embodiment of the present invention is a fluid transport device used by being implanted subcutaneously, and an exterior case and an injection opening that is exposed to the outside of the exterior case and can inject fluid from the outside. Including a port, a reservoir for storing fluid injected from the port, a fluid conducting portion communicating with the reservoir and conducting the fluid, and a micropump for supplying the fluid to the outside through the fluid conducting portion And a battery for supplying power to the micropump pump,
The exterior case has a skin side corresponding surface that corresponds to the skin side when embedded under the skin,
The port is provided on the skin side corresponding surface.

According to the above configuration, the fluid transport device of the present invention includes the outer case, the port, the reservoir, the fluid conducting portion, the micropump, and the battery as described above, and is completed as a self-contained type. Since it is a fluid transporting device, it can be implanted in the body of an experimental animal or the like (which includes the human body, and is used in the present specification for the same purpose) as it is. No connection is required. Therefore, there is no inflammation in laboratory animals.
In addition, since the fluid transportation device of the present invention is self-contained, it can supply a fluid such as a chemical solution into the body by itself, and the supply conditions of the chemical solution and the like can be appropriately set by controlling the operation of the micropump. Easy to control.

Moreover, the fluid transport device of the present invention is used by being implanted under the skin of a laboratory animal or the like, and the port faces the skin side of the animal or the like when the fluid transport device is implanted under the skin. Therefore, it is easy to inject a chemical solution or the like into the port. In other words, when it is necessary to replenish a chemical solution etc., since the port is arranged toward the skin side of the animal etc., it becomes easy to find the location of the port, and the chemical solution etc. can be easily put in the port. Can be injected. The case where the above-described chemical solution or the like needs to be supplied may be the case where the chemical solution or the like is supplied immediately after the fluid transportation device is implanted under the skin of the experimental animal, or when the experiment progresses and the chemical solution or the like decreases. .
The chemical solution refers to a chemical solution for developing a new drug for medical use, a nutrient solution for nutritional supplementation for small animals, and the like, and other liquids that have medicinal effects.

Further, the fluid transport device according to Embodiment 13 of the present invention is the fluid transport device according to Embodiment 12 of the present invention, wherein the reservoir and the micropump are arranged apart from each other in plan view,
The port is arranged between the reservoir and the micropump in plan view.

According to the said structure, it has an effect described in this Embodiment 12. FIG.
Furthermore, in the present invention, since the reservoir and the micropump are arranged apart from each other in a plan view and do not substantially overlap each other in a plan view, the entire apparatus becomes thin. Since the reservoir needs to store as much fluid as a chemical solution as much as possible, and the micropump supplies the chemical solution etc. efficiently and powerfully, both of them have a relatively large capacity volume for the fluid transport device. .
Therefore, when the reservoir and the micropump are not in a positional relationship apart from each other in a plan view (viewed from the plane direction) but are overlapped with each other, a cross-sectional view (a thickness direction perpendicular to the plan view) As a result, the entire fluid transportation device becomes thick. Then, if it is implanted under the skin of a laboratory animal or the like, it will unnecessarily pull the skin, or it may cause pressure and cause discomfort and damage.

On the other hand, according to the present invention, since the entire apparatus is thin, it is difficult to give the above-mentioned discomfort. In other words, even if it is implanted under the skin of a laboratory animal, etc., it is less likely to cause an uncomfortable feeling to the laboratory animal such as pulling or pressing the skin, and it is less likely to cause damage. Can be used in the state.
In addition, since the reservoir and the micropump that want to ensure a relatively large volume capacity do not substantially overlap each other in plan view, the dimensions in the cross-sectional view direction (thickness dimensions) do not interfere with each other. It is also possible to secure the maximum thickness dimension. Therefore, the reservoir can store a large amount of chemical liquid and the like, and the micropump can efficiently and powerfully supply the chemical liquid and the like.
In addition, since the port is disposed between the reservoir and the micropump in the above-described plan view, the thinness of the entire apparatus is not impaired.

  Furthermore, as described above, the port inserts an injection needle-like liquid injection tool from the outside for replenishment of a chemical solution, etc., but an external force is applied to the insertion at that time, or the opposite direction also occurs when it is withdrawn. An external force is applied, and pressure acts on the entire fluid transportation device. However, in the present invention, since the port is disposed between the reservoir having a large surface area and the micropump, the placement position of the liquid injection port is substantially in plan view of the entire fluid transportation device. Near the center. Therefore, even when the pressure when the injection needle-like liquid injector is inserted into the port or when the pressure is withdrawn, the entire fluid transport device receives the pressure, and the entire fluid transport device is inclined. Less. Therefore, the operation for injecting and removing the liquid injection tool and the liquid injection operation are performed smoothly. Further, since the entire apparatus does not tilt, no local pressure is applied to the experimental animal or the like, and no local pain is given. Therefore, the burden on experimental animals and the like can be reduced, and experiments can be continued favorably.

Further, the fluid transport device according to Embodiment 14 of the present invention is the fluid transport device according to Embodiment 12 or Embodiment 13 of the present invention, wherein the port includes a projecting portion formed so as to project from the exterior case. The injection opening is formed in the upper part.
According to the said structure, it has an effect described in this Embodiment 12. FIG.
Furthermore, the present invention has the following specific effects because the port includes a protruding portion that protrudes from the outer case.
That is, even if the fluid transport device is implanted under the skin of a laboratory animal or the like, it becomes easy to recognize the location of the port from the outside. That is, the port of the present invention has the protruding portion as described above, and the protruding portion protrudes from the outer case, so that the epidermis of the experimental animal or the like is locally raised. This is because the fluid transport device is embedded in a specific place such as a laboratory animal under the skin, that is, since the skin (skin) is relatively thin and embedded under the skin, the skin is easily raised by the protrusions. Therefore, an experimenter or the like (which means all persons who want to inject a fluid such as a chemical solution, and is used in the present specification with the same meaning) can easily recognize the location of the port. For this reason, the experimenter or the like can easily insert a liquid injection tool into the center of the raised portion of the epidermis, and can supply a chemical solution or the like to the reservoir.

Further, the fluid transport device according to Embodiment 15 of the present invention is the fluid transport device according to any one of Embodiments 12 to 14 of the present invention, wherein the battery overlaps the reservoir in plan view, It is characterized by being arranged on the opposite side of the port with the reservoir in view.
According to the above configuration, the battery overlaps with the reservoir in a plan view and is disposed on the opposite side of the port with the reservoir in a cross-sectional view. Therefore, the reservoir that requires a large area in the plan view Compared with the case where the batteries are arranged apart from each other in a plan view, a chemical solution supply device having a small plan view area can be obtained.
In addition, since the port is disposed close to the reservoir in the cross-sectional view direction (thickness direction), the flow path for supplying the chemical liquid or the like from the port to the reservoir is shortened, and the chemical liquid or the like is supplied to the reservoir more reliably. It will be. Further, since the flow path is shortened as described above, the space of the fluid transport device can be reduced.

The fluid transportation device according to Embodiment 16 of the present invention is the fluid transportation device according to any one of Embodiments 12 to 15 of the present invention, wherein the port does not overlap the battery in plan view. It is characterized by being arranged.
According to the above configuration, since the port is arranged at a position that does not overlap the battery in plan view, the port can be configured in the cross-sectional view direction without being obstructed by the relatively thick battery. Therefore, the conduction path from the port to the reservoir can be arranged at the optimum height position. Moreover, since the guide opening when the liquid injection tool is inserted into the port from the outside can be secured deeply, the injected liquid injection tool is supported by the guide opening, and the replenishment operation of the chemical liquid or the like is stabilized.
In addition, the thickness dimension in the cross-sectional view direction of the battery can be increased, and a battery having a large capacity can be employed as described above.

In addition, the fluid transport device according to Embodiment 17 of the present invention is the fluid transport device according to any one of Embodiments 12 to 16 of the present invention, wherein the IC controls the operation of the micropump, and the IC And a signal supply port exposed in the outer case so as to supply a control program for controlling the operation of the micropump to the IC.
According to the above configuration, first, the operation of the micropump is controlled by the IC.
This IC may be composed of a logic circuit or a microcomputer. Therefore, it is possible to appropriately control the operation of the micropump, particularly the rotation drive unit. Therefore, it is easy to set the start and stop of driving of the fluid transport device, and it is possible to appropriately control the supply amount of a chemical solution or the like during an animal experiment, so that an animal experiment or the like can be performed effectively. I can do it.
Further, according to the above configuration, since the signal supply port is provided and is exposed at the exterior case, the driving conditions of the micropump can be set as needed after the fluid transport device is assembled. Therefore, the drive program can be stored before the fluid transportation device is embedded in the experimental animal or the like, or even during an animal experiment or the like, an experiment is performed using a signal line connected to the signal supply port and drawn out from the body of the experimental animal or the like. The program can be changed and input according to the state or the like.

In addition, the fluid transport device according to Embodiment 18 of the present invention is the fluid transport device according to any one of Embodiments 12 to 17 of the present invention, and is attached to an installation target such as an animal in the exterior case. The attachment part is formed.
According to the above configuration, the fluid transportation device can be easily attached to an animal or the like by entanglement such as winding a thread around the attachment portion and sewing the thread to the animal or the like.
The mounting portion is provided at a height as shown in the drawing (disposed away from the back surface of the exterior case to the skin side corresponding surface side), so that the fluid transport device can be threaded to the experimental animal or the like. When sewing and fixing, the sewn part of experimental animals, etc. can be brought close to the plan view position of the mounting part, the fluid transportation device can be attached so as to be pulled down directly, and attached so as not to float. it can.

In addition, Embodiment 19 of the present invention is a chemical solution supply device (fluid transport device) that is implanted under the skin of an animal or the like, and can expose the exterior case and the exterior of the exterior case to inject the chemical solution (fluid) from the outside. Via a liquid injection port (port) having an injection opening, a reservoir for storing a chemical liquid injected from the liquid injection port, a chemical liquid conduction part communicating with the reservoir and conducting a chemical liquid, and the chemical liquid conduction part A micropump for supplying the chemical solution to the outside, and a battery for supplying power to the micropump,
The liquid injection port is arranged toward the skin side of the animal when the chemical liquid supply device is implanted under the skin,
The reservoir, the micropump, and the battery are arranged at positions separated from each other in a plan view.

According to the said structure, it has an effect described in this Embodiment 12. FIG.
Further, according to the present invention, since the reservoir, the micropump, and the battery are arranged apart from each other in a plan view and do not substantially overlap with each other in a plan view, the entire apparatus becomes thin. Because the reservoir needs to store as much chemical as possible, and the micropump supplies chemical liquid efficiently and powerfully, the battery can secure a large battery capacity and drive the micropump powerfully or drive time Each of them has a relatively large capacity volume for the chemical supply device.
Therefore, if the combination of at least one of the reservoir, the micropump, and the battery overlaps in plan view, the entire chemical supply device becomes thick. Then, by embedding under the skin of a laboratory animal or the like, the skin is unnecessarily pulled, or pressure is applied and damaged.

On the other hand, the present invention is thin, so that even if it is implanted under the skin of a laboratory animal or the like, it does not unnecessarily pull the skin or cause pressure or damage, giving the laboratory animal a sense of incongruity. Therefore, it can be used in a state close to usual for laboratory animals.
In addition, the reservoir, the micropump, and the battery for which a relatively large capacity is to be secured do not substantially overlap each other in plan view, so that the dimensions (thickness dimensions) in the sectional view direction do not interfere with each other. It is also possible to ensure the maximum dimensions. Therefore, the reservoir can store a large amount of the chemical solution, the micropump can supply the chemical solution efficiently and powerfully, and the battery can drive the micropump powerfully or can maintain the driving time for a long time.
In addition, the description regarding the fluid transport apparatus described in any one of the embodiment 16 to the embodiment 18 of the present invention is also applied to the embodiment 19 of the present invention.

In addition, the embodiment 20 of the present invention is a chemical solution supply device (fluid transport device) for subcutaneous implantation of an animal or the like according to any one of the embodiments 12 to 19 of the present invention,
The liquid injection port (port) is arranged substantially at the center in the narrow width direction which is narrow in the chemical liquid supply device in plan view.
According to the above configuration, since the liquid injection port is arranged at the substantially center in the narrow width direction that is narrow in the chemical liquid supply device in plan view, the liquid injection tool is inserted into the liquid injection port from the outside. In addition, when being pierced, the chemical supply device is prevented from tilting in the narrow direction.
Therefore, as described above, even when the pressure when the liquid injection tool is inserted into the liquid injection port or when the pressure is withdrawn, the entire chemical liquid supply apparatus receives the pressure, and thus the entire chemical liquid supply apparatus Is less inclined. Therefore, the liquid injection tool is well inserted and removed, and a smooth liquid injection operation is performed. Further, since the entire apparatus does not tilt, no local pressure is applied to the experimental animal or the like, and no local pain is given. Therefore, the burden on experimental animals can be reduced and the experiment can be continued well.
Therefore, the liquid injection port is disposed at the approximate center in the narrow width direction, which is narrow in the chemical liquid supply device in plan view, and the reservoir and micropump in plan view as in the thirteenth embodiment of the present invention. If it arrange | positions so that both of being arrange | positioned between may be satisfied, the effect mentioned above will be increased more.

Note that the narrow width direction, which is narrow in the chemical solution supply device in plan view, refers to the narrower width direction in which the width dimension is small in plan view of the chemical solution supply device.
As another way of viewing, the narrow width direction refers to a direction substantially perpendicular to a straight line connecting the central portion or the center of gravity of the reservoir and the central portion or the center of gravity of the micropump in a plan view in the thirteenth embodiment of the present invention.
Therefore, the planar view shape of the chemical solution supply apparatus is a planar shape having a width dimension in the wide direction (longitudinal direction) and a width dimension in the narrow width direction (short direction), such as a substantially rectangular shape, an oval shape, an elliptical shape, etc. Then, in general, the linear direction connecting the central portion or center of gravity of the reservoir and the central portion or center of gravity of the micropump in the plan view is the longitudinal direction, and the direction substantially perpendicular to the longitudinal direction is the narrow width direction (short direction). Become. Further, when the longitudinal direction or the narrow width direction (short direction) cannot be determined as in the case where the shape of the chemical solution supply device in plan view is substantially circular or irregular, the width referred to in Embodiment 18 of the present invention. As described above, the narrow direction is regarded as a direction substantially perpendicular to a straight line connecting the central portion or center of gravity of the reservoir and the central portion or center of gravity of the micropump in plan view.

In addition, the embodiment 21 of the present invention is a chemical solution supply device (fluid transport device) for subcutaneous implantation of an animal or the like according to any one of the embodiments 12 to 20 of the present invention,
The liquid injection port (port) is disposed inward of the injection opening, and a liquid injection tool penetrable member made of an elastic material through which the liquid injection tool can penetrate, and the liquid injection tool penetrable member penetrating the liquid injection port. And a chemical solution supply unit for supplying the chemical solution injected from the liquid injector to the reservoir.
According to the above configuration, the liquid injection port includes the liquid injection member penetrable member made of an elastic material that is disposed inward of the injection opening and is capable of penetrating the liquid injection tool. In other words, since it has the role of a lid, it is prevented that liquids such as body fluids and other gases enter the inside of the chemical solution supply device when the chemical solution supply device is buried under the skin of the experimental animal. . Therefore, the chemical solution is prevented from being contaminated by the body fluid or gas.
Furthermore, since the liquid injection tool penetrable member is formed of an elastic material, the liquid injection tool can be inserted into the liquid injection tool penetrable member from the outside for liquid injection. Therefore, the chemical solution is supplied from the liquid injection port to the reservoir.
As described above, the liquid injection member penetrable member made of the elastic material prevents contamination of the chemical liquid and allows the liquid injection tool to penetrate, so that the chemical liquid can be replenished.

In addition, the embodiment 22 of the present invention is a chemical solution supply device (fluid transport device) for subcutaneous implantation of an animal or the like according to any one of the embodiments 12 to 21 of the present invention,
The reservoir is connected to the liquid injection port (port) at one end of the side wall, the chemical liquid discharge part is connected to the chemical liquid conduction part (fluid conduction part) at the other end of the side wall, and the chemical injection part A chemical solution storage unit formed in the middle of the chemical solution discharge unit is provided.
According to the above configuration, in the reservoir, the chemical liquid injection part and the chemical liquid discharge part are provided at one end of a side wall (a horizontal wall that is not an upper wall in the vertical direction or a lower wall), and the thickness direction ( Since it is not provided in the cross-sectional view direction and the height direction), the reservoir is not thickened as in the case where the chemical solution injection portion and the chemical solution discharge portion are provided to protrude in the thickness direction. Therefore, the chemical solution supply device is thin.
The reservoir is configured such that a chemical solution is injected at a chemical solution injection portion provided at one end and communicated with the liquid injection port, and a chemical solution is discharged at a chemical solution discharge portion provided at the other end and communicated with the chemical solution conduction portion. The medicinal solution injected in the medicinal solution injecting unit is stored in the intermediate medicinal solution storing unit and discharged in the medicinal solution discharging unit, so that the flow of the medicinal solution is continuous and the air in the reservoir is easily released. It will flow smoothly without delay.

Further, the embodiment 23 of the present invention is a chemical solution supply device (fluid transport device) for subcutaneous implantation of animals or the like according to any one of the embodiments 12 to 22 of the present invention,
The said chemical | medical solution conduction | electrical_connection part (fluid conduction | electrical_connection part) is comprised with the tube which has elasticity.
According to the above configuration, since the chemical liquid conducting portion is configured by an elastic tube, the position of the chemical liquid flow path after the reservoir can be moved, and the shape thereof can be slightly modified. Even if a slight dimensional error occurs in each member, the elastic tube has elasticity, so that it is easy to correct its position and shape. Therefore, a good chemical solution flow path can be ensured even if the dimensions of the related members vary.
Furthermore, since the flow path is a tube, the cross section of the flow path can be round, and in this case, a highly efficient cross-sectional area can be obtained, so that a large amount of chemical solution can be supplied.

In addition, the embodiment 24 of the present invention is a chemical solution supply device (fluid transport device) for subcutaneous implantation of an animal or the like according to any one of the embodiments 12 to 23 of the present invention,
The micropump includes a rotation driving unit, a cam unit rotated by the rotation driving unit, and a plurality of pressing pins that sequentially press the tube in a radial direction by the cam unit. By pressing, the chemical solution is discharged to the outside.
According to the above configuration, since the micropump presses the tube sequentially by the cam portion rotated by the rotation drive portion, the mechanical drive force of the rotation drive portion, the cam portion, and the press pin is used. You can press the tube. Therefore, since the operation is reliable and relatively strong, a chemical solution in the tube can be sent out reliably and powerfully. Further, since the pressing pin presses the tube in the radial direction with respect to the rotation center of the cam portion, the operation of the pressing pin is stable and the tube can be pressed stably.

Further, the embodiment 25 of the present invention is a chemical solution supply device (fluid transport device) for subcutaneous implantation of an animal or the like according to any one of the embodiments 12 to 24 of the present invention,
The tube is formed between a reservoir connecting portion whose one end communicates with the reservoir, a chemical solution discharging portion where the other end is discharged to the outside, and an intermediate portion between the reservoir connecting portion and the chemical discharging portion. And an arcuate tube portion disposed on the outer peripheral side in a plan view with respect to the pin.
According to the above configuration, the tube forms an arcuate tube portion between the reservoir connecting portion and the chemical solution discharge portion, and the arcuate tube portion forms a part of the micropump. Therefore, it is possible to improve efficiency by using both the chemical solution conduction part and the micropump.
In addition, since the tube of this portion is formed in an arc shape, a necessary amount of the arc-shaped tube portion is secured, and thus a plurality of necessary pressing pins are arranged. In addition, since the cam portion and the pressing pin are arranged on the arc center side of the arc-shaped tube portion, the arc center side region can be used effectively, and the space of the micro pump can be reduced.
Even if the pressing pin protrudes and presses the tube, the tube can return the pressing pin to its original position due to its elasticity. In this case, the number of components can be reduced by eliminating the need for a return spring member. In addition, when the pressing pin returns, the tube returns to the original cross-sectional shape due to its elasticity, so that the flow path diameter is secured.

Further, the embodiment 26 of the present invention is a device for supplying a drug solution for subcutaneous implantation such as an animal according to any one of the embodiments 12 to 18 and 20 to 25 of the present invention. Fluid transport device),
The battery is characterized in that it overlaps with the rotation drive part of the micropump in a plan view and is arranged on the opposite side of the tube across the rotation drive part in a sectional view.
According to the above configuration, the battery is not directly mechanically related to the tube. In addition, the battery is disposed close to the rotation drive unit of the micropump in a plan view, but is disposed on the opposite side of the tube in a cross-sectional view, and thus depends on the tube and the rotation drive unit. The battery does not interfere with the configuration of the micropump. Therefore, the structure of the tube and the rotation drive unit can be optimally configured.

In addition, the embodiment 27 of the present invention is a chemical solution supply apparatus (fluid transport apparatus) for subcutaneous implantation of an animal or the like according to any one of the embodiments 12 to 26 of the present invention,
The outer case is characterized in that an upper lid is made of a transparent material, and at least the reservoir, micropump, and tube are visible from the upper lid.
According to the above configuration, since the upper lid is made of a transparent material, at least the reservoir, the micropump, and the tube can be visually recognized from the upper lid. Therefore, even after the chemical liquid supply apparatus is assembled, the reservoir, Abnormalities in assembly and operation of micropumps and tubes can be found from outside. If the above abnormality is discovered, improvement can be achieved before implantation in an animal or the like.

Further, the fluid transport device according to Embodiment 28 of the present invention is the fluid transport device according to Embodiment 12 of the present invention, wherein the exterior case has an inclined surface on at least a part of the outer wall from the skin-side corresponding surface toward the back surface. It is characterized by providing.
According to the above configuration, by forming the inclined surface on the outer wall of the outer case, when the fluid transport device is mounted in the living body, the biocompatibility between the living tissue and the outer case is good at the portion where the inclined surface is formed. Therefore, it is possible to suppress damage to living tissue and a sense of discomfort due to wearing.

In addition, in the fluid transport device according to Embodiment 29 of the present invention, in the fluid transport device according to Embodiment 28 of the present invention, the exterior case has a gripping vertical surface on the outer wall from the corresponding surface on the skin side toward the back surface. According to the above configuration, the fluid transportation device can be easily fixed by grasping the vertical surface for gripping through the skin after the fluid transportation device is implanted subcutaneously. The workability when this device needs to be fixed can be improved.

Further, the fluid transport device according to Embodiment 30 of the present invention is the fluid transport device according to Embodiment 28 or 29 of the present invention, wherein the inclined surface is narrow at one end in the wide direction of the outer case. The narrow side outer wall formed in the direction and the narrow side outer wall formed in the narrow direction at the other end of the wide direction are widened from the back surface of the exterior case toward the skin side corresponding surface. It is formed so as to be inclined so that the width in the direction becomes narrow.
According to the above configuration, when the inclined surface is formed, the skin of the animal is pulled according to the volume and height of the chemical solution supply device when implanted under the skin of the animal. The skin will be damaged. Therefore, by forming the inclined surface so that the tension is as small as possible and local shearing force is not applied to the skin, the width on the side close to the skin is particularly narrow, so as described above. Damage to the skin can be prevented as much as possible.
The inclination angle of the inclined surface is preferably 5 to 60 degrees, and more preferably 15 to 30 degrees. The inclination angles of the inclined surfaces may be the same or different.

In addition, the fluid transport device according to Embodiment 31 of the present invention is the fluid transport device according to any one of Embodiments 28 to 30 of the present invention, wherein the inclined surface extends in a narrow direction in the exterior case. The wide side outer wall formed in the wide direction at one end and the wide side outer wall formed in the wide direction at the other end in the narrow direction are directed from the back surface of the outer case to the skin side corresponding surface. According to the above, it is formed to be inclined so that the width in the narrow direction becomes narrow.
According to the above configuration, when the outer case is formed with the inclined surface as described above, as described in the embodiment 30 of the present invention, when the fluid transport device is embedded in the body of an animal or the like. Even in the narrow direction, it is possible to minimize the pulling of the skin of animals or the like according to the volume and height of the fluid transport device, and the width on the side close to the skin is particularly narrow. Damage to the skin is prevented as much as possible.

Further, the fluid transport device according to Embodiment 32 of the present invention is the fluid transport device according to Embodiment 12 of the present invention, wherein the exterior case is formed on the skin-side corresponding surface formed in a convex surface along the wide direction, It has at least one among the back surfaces of the said skin side corresponding | compatible surface formed in the concave surface along the said wide direction, It is characterized by the above-mentioned.
According to the above configuration, when the fluid transporting device is implanted in the body of an animal or the like, the skin-side corresponding surface is formed in a convex shape or the back surface is formed in a concave shape. Since it is formed into an upper surface shape and a lower back surface shape substantially along the subcutaneous shape, it is easy to become familiar with the skin and the like, and it is possible to prevent the animal from being forcedly pulled or damaged. In this case, the skin-side corresponding surface is formed in a convex shape, and at the same time, the back surface is formed in a concave shape. Etc., and the above-mentioned effects can be made more effective.

Further, the fluid transport device according to Embodiment 33 of the present invention is the fluid transport device according to Embodiment 12 or 32 of the present invention, wherein the outer case is formed in a convex surface along the narrow direction. At least one of the skin side corresponding surface and the back surface of the skin side corresponding surface formed in a concave surface along the narrow direction is provided.
According to the above configuration, the outer case is formed on the convex surface or / and the concave surface as described above, so that the fluid transport device is in the body of an animal or the like as described in the embodiment 30 of the present invention. When it is embedded in the skin, it is easy to become familiar with the skin etc. because it is formed in the skin side corresponding surface shape and the back surface shape almost along the subcutaneous shape of the animal etc. And damage can be prevented.

  ADVANTAGE OF THE INVENTION According to this invention, the fluid transport apparatus which can be made to supply fluids, such as a chemical | medical solution stably, can reduce the burden on an animal etc. can be provided.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.
[First Embodiment]
1 to 6 show a fluid transportation device according to a first embodiment of the present invention, FIG. 1 shows a configuration in a thickness direction, FIG. 2 shows a configuration in a plane direction, and FIG. 3 shows a watch as a drive transmission mechanism. FIG. 4 is a cross-sectional view showing a part of the drive transmission mechanism and the fluid transport mechanism, FIG. 5 is a cross-sectional view showing a structure related to fluid injection and outflow, and FIG. 6 is a plan view showing the fluid transport mechanism. It is.
In the present embodiment, a fluid transportation device that is attached to a living body such as a human body or an animal and uses a chemical as a fluid will be described as an example. The fluid includes a gel fluid and further includes a gas.

1 and 2 are a cross-sectional view and a plan view showing a basic configuration of a fluid transportation device 1 according to the first embodiment of the present invention. 1 and 2, the fluid transport device 1 of the present embodiment has a fluid transport mechanism 2 disposed on the upper surface of the drive transmission mechanism 3, and the drive transmission mechanism 3 and the fluid transport mechanism 2 do not overlap with each other in plan view. The reservoir 60 is disposed, and a valve 80 as a port (hereinafter referred to as a valve in the first embodiment) is disposed in a planar space between the drive transmission mechanism 3 and the reservoir 60.
Furthermore, a circuit board 5 on which a control circuit (not shown) for driving control of the drive transmission mechanism 3 is mounted is disposed on the back side of the drive transmission mechanism 3 (the surface opposite to the fluid transport mechanism 2). A battery 4 as a power source is disposed below the reservoir 60.
The fluid transport mechanism 2, the drive transmission mechanism 3, the reservoir 60, the valve 80, the battery 4, and the circuit board 5 are provided with an outlet 53 of the tube 50 in the sealed space of the outer case formed by the upper lid 13 and the lower lid 16. Except for being stored.

The drive transmission mechanism 3 employs a watch movement and utilizes only a step motor and a train wheel of a small movement having a barrel-shaped planar outer shape. The detailed structure of the drive transmission mechanism 3 will be described later with reference to FIGS.
The hour wheel at the final stage of the train wheel disposed in the center of the drive transmission mechanism 3 is a cam drive wheel 76, and a cylindrical shaft portion 76 a of the cam drive wheel 76 projects in the direction of the fluid transport mechanism 2. The cam is mounted on the shaft portion 76a (see FIG. 2).
The cam is composed of a first cam 20 pivotally supported by the shaft portion 76a and a second cam 30 pivotally supported by the shaft portion 76a. The second cam 30 is rotated by the first cam 20, The first cam 20 and the second cam 30 function as if they were one cam.

The fluid transport mechanism 2 includes the first cam 20 and the second cam 30 described above, and the seven fingers 40 interposed between the elastic tube 50 and the tube 50, the first cam 20, and the second cam 30. To 46.
The tube 50 has elasticity, and in this embodiment, is made of biocompatible silicone rubber, and is attached to the tube guide groove 121 of the tube frame 12 that is a machine frame of the fluid transport mechanism 2. In the tube guide groove 121, a tube guide wall 122 is provided on a concentric circle centered on the rotation center P of the cam drive wheel 76.

The fingers 40 to 46 are interposed between the tube 50, the first cam 20, and the second cam 30 at equal intervals from the rotation center P, and finger guide grooves 126 formed in the tube frame 12, respectively. (See FIG. 4).
These fingers 40 to 46 are mounted so as to be movable in the axial direction in the finger guide grooves 126, and are pressed by the first cam 20 and the second cam 30 to close the tube 50. The operation of the fluid transport mechanism 2 will be described later with reference to FIGS.

One end of the tube 50 is an outflow port 53 through which the chemical solution flows out, and extends to the outside of the fluid transport device 1. The other end is a fluid inflow port 52 that communicates with the reservoir 60, and communicates with the reservoir 60 via a connecting pipe 55.
The reservoir 60 is formed of a thin-walled sachet that swells when filled with a chemical solution and whose volume can be reduced when the chemical solution flows out. The reservoir 60 has a substantially semicircular planar shape, and one end of a portion corresponding to the string is a fluid discharge port 63 and is connected to the connection pipe 55 described above. The other end is a fluid injection port 62 and is connected to an injection pipe 83 protruding from the valve 80.
In this way, a chemical solution flow path of the valve 80, the reservoir 60, and the tube 50 is formed.

The drive transmission mechanism 3 described above is held by the movement frame 15, the fluid transport mechanism 2 is held by the tube frame 12, and the reservoir 60 is held in a space formed by the tube frame 12 and the movement frame 15. Yes. The tube frame 12 and the movement frame 15 are sandwiched between the upper lid 13 and the lower lid 16. A fixed shaft 95 is planted in the movement frame 15, and both ends of the fixed shaft 95 pass through the tube frame 12, the upper lid 13, and the lower lid 16, and the tube frame 12 and the movement are fixed by fixing screws 90 and 91. The frame 15, the upper lid 13, and the lower lid 16 are firmly fixed. The planar arrangement of the fixing screw 90 (95) is shown in FIG.
The outflow port 53 is fixed to the vicinity of the outer periphery of the tube frame 12 with an adhesive or the like, and the connecting pipe 55 is also fixed to the tube frame 12 with an adhesive or the like to form a sealed structure with the upper lid 13. Intrusion into the body fluid or the like from both ends of 50 is prevented.

A quartz substrate as a timing element (not shown), an IC 6 as a control circuit, and a lead substrate (not shown) for supplying power from the battery 4 to the IC 6 are mounted on the circuit board 5. Further, a pattern for transmitting a drive signal to the step motor of the drive transmission mechanism 3 is formed, and this pattern is connected to the terminals 101a and 101b (see FIG. 3) of the step motor.
The battery 4 is a button-type small battery for a watch, and is disposed at a position overlapping with a part of the reservoir 60, and supplies power to the IC 6 via the lead substrate described above.
The drive transmission mechanism 3 and the circuit board 5 are screwed and fixed to the movement frame 15 by a fixed shaft 96, a fixed screw 91, and a fixed shaft 92 that are planted in the movement frame 15.

  Both the upper lid 13 and the lower lid 16 have an oval shape in plan view, and the cross-sectional shape of each outer peripheral portion is gently rounded and has a substantially streamlined shape when assembled. This is a shape that is considered in order to increase the affinity with a living tissue when the fluid transport device 1 of the present invention is mounted in the living body. Further, the upper lid 13, the lower lid 16, the tube frame 12, and the movement frame 15 are excellent in biocompatibility and have rigidity necessary for normal use.

Next, the configuration of the drive transmission mechanism 3 will be described in detail with reference to FIGS. 3 and 4.
FIG. 3 is a plan view showing a watch movement as the drive transmission mechanism 3, and FIG. 4 shows a cross-sectional structure of the train wheel of the watch movement and the fluid transport mechanism 2. In FIG. 3, the drive transmission mechanism 3 has a train wheel supported between a first machine casing 11 (corresponding to a ground plane in a watch) and a second machine casing 14 (corresponding to a train wheel bridge in a watch). .
A step motor including a coil block 101, a stator 102, and a step rotor 70 is provided. Since the configuration of the step motor is known, the description thereof is omitted.

Next, the structure of the train wheel will be described. 3 and 4, the step rotor 70 of the step motor includes a permanent magnet 70 a and rotates due to the attractive and repulsive force of the stator 102. The rotation of the step rotor 70 is transmitted to the cam drive wheel 76 by sequentially meshing the first transmission wheel 71, the second transmission wheel 72, the third transmission wheel 73, and the fourth transmission wheel 74.
Here, the second transmission wheel 72 corresponds to a second hand wheel for attaching the second hand of the watch, the fourth transmission wheel 74 is a minute hand wheel for attaching the minute hand of the watch, and the cam driving wheel 76 is an hour hand wheel for attaching the hour hand of the watch ( It may be referred to as an hour wheel). The transmission wheels from the first transmission wheel 71 to the cam drive wheel 76 are collectively referred to as a train wheel.
The step rotor 70, the first transmission wheel 71, the third transmission wheel 73, and the fourth transmission wheel 74 are rotatably supported by the first machine frame (base plate) 11 and the second machine frame (wheel train receiver) 14. Has been. A transmission axle 75 is planted on the first machine casing 11, and the cylindrical portion protrudes upward (in the direction in which the first cam 20 and the second cam 30 are disposed). The cylindrical portion of the fourth transmission wheel 74 is inserted into the through hole formed in the transmission wheel shaft 75, and the shaft portion of the second transmission wheel 72 is inserted into the through hole formed in the fourth transmission wheel 74. Therefore, normally, the cam drive wheel 76 makes one rotation in 12 hours, but in this embodiment, the step rotor 70 is accelerated 45 times.

In the second transmission wheel 72, one support shaft is pivotally supported by the second machine casing 14, and the other shaft portion is pivotally supported by a through hole formed in the fourth transmission wheel 74. Then, the rotation of the fourth transmission wheel 74 is transmitted to the cam drive wheel 76 via a fifth transmission wheel 79 (not shown) (see FIG. 3).
The cam drive wheel 76 is pivotally supported by inserting a through hole formed in the center into the outer periphery of the cylindrical portion of the transmission axle 75. The shaft portion 76a of the cam drive wheel 76 projects in the direction in which the first cam 20 and the second cam 30 are disposed. The upper part of the shaft portion of the cam drive wheel 76 is pivotally supported by a cam drive wheel support bearing 78 planted on the upper lid 13. The upper lid 13 is provided with a hole for pivotally supporting the cam drive wheel support bearing 78. This hole does not penetrate the upper cover 13, and the end of the cam drive wheel support bearing 78 is sealed by the upper cover 13. ing. The cam drive wheel 76 is rotated at a predetermined rotation speed by the transmission wheels described above for the rotation of the step rotor 70.
The cam drive wheel 76 is pivotally supported by the transmission wheel shaft 75 and the cam drive wheel support bearing 78, so that the distance between the support portions becomes long, and the amount of inclination of the cam drive wheel 76 is suppressed. The side pressure applied to the shaft portion of the cam drive wheel 76 generated by the load torque of the first cam 20 and the second cam 30 is reduced.

Next, the cross-sectional structure of the fluid transport mechanism 2 will be described with reference to FIG. The fluid transport mechanism 2 is disposed on the upper surface of the first machine frame 11 so as to overlap the drive transmission mechanism 3 described above. The second cam 30 and the first cam 20 are inserted in this order from below into the protruding shaft portion 76a of the cam drive wheel 76. Here, the second cam 30 is pivotally supported by the cam drive wheel 76 so as to be loosely fitted, and the first cam 20 is fixed so as to rotate integrally with the cam drive wheel 76.
A tube frame 12 is provided around the first cam 20 and the second cam 30. The tube frame 12 is sandwiched between the above-described upper lid 13 and the first machine frame 11, and the upper lid 13, the tube frame 12, and the first machine frame 11 are overlapped and screwed together by a fixing screw (not shown) and connected to each other. The face is intimate.

Next, the structure in the vicinity of the valve 80, the reservoir 60, and the tube outlet 53 will be described with reference to the drawings.
FIG. 5 is a cross-sectional view showing a structure related to fluid injection and outflow. In FIG. 5, the valve 80 includes a valve body 81 having an L-shaped flow portion, and a fluid injection plug 82 having elasticity that is press-fitted into the valve body 81. An injection pipe 83 projects from the valve body 81 and is connected to the reservoir 60. The fluid injection plug 82 is provided with a slit 82b (see also FIG. 2).

  Here, a method for injecting the chemical into the reservoir 60 will be described. For injecting the chemical solution into the reservoir 60, an injection needle-like injection needle (not shown) is inserted into the slit 82 b of the fluid injection plug 82 described above to inject the chemical solution into the reservoir 60. The injection needle can be easily inserted by providing the slit 82b. When the injection needle is removed after the chemical solution is injected, the fluid injection plug 82 is closed by the elastic force of the fluid injection plug 82 itself, and the fluid can be prevented from flowing out from the valve 80. Such a valve 80 can realize a simple structure that does not use a valve or the like, and can repeat the injection of the chemical solution.

Further, when the chemical solution is injected from the valve 80, it moves from the arrow F1 toward the fluid discharge port portion 63, and the fluid discharge port portion 63 and the fluid injection port portion 62 are separated from each other. The generation of vortex and pulsating flow can be suppressed, and the fluid smoothly moves from the connection pipe 55 into the fluid flow portion 51 of the tube 50 (in the direction of arrow F2).
In addition, an injection needle guide portion 82a is formed on the upper surface of the fluid injection plug 82 so that the insertion of the injection needle is guided and the substantially central portion of the slit 82b can be inserted.

  Further, the vicinity of the outlet portion 53 of the tube 50 is bent down toward the center in the thickness direction of the fluid transport device 1 along the shape of the outer peripheral portion of the upper lid 13. The shape of the bent-down portion is formed by the tube extraction portion 132 of the upper lid 13 and the tube extraction portion 152 of the movement frame 15. The reason why the outlet portion 53 of the tube 50 is formed in this way is that when the fluid transport device 1 of the present invention is mounted in a living body, if the tube 50 remains in a shape protruding from the outer shape, the living tissue and the tube 50 This is because the affinity with is considered to be impaired.

Then, the effect | action of the fluid transport apparatus 1 which concerns on this embodiment is demonstrated with reference to drawings.
FIG. 6 is an explanatory diagram showing the operation of the fluid transport device 1. This will be described with reference to FIG. First, the shape and function of the first cam 20 and the second cam 30 will be described with reference to FIG. The first cam 20 is formed with three protruding finger pressing portions 21 a to 21 c on the outer peripheral portion, and the second cam 30 is formed with one protruding finger pressing portion 32. These tube pressing portions are formed at equal intervals on concentric circles equidistant from the rotation center P.

The finger pressing portions 21 a to 21 c and 32 are set to dimensions that allow the fingers 40 to 46 to close the tube 50. In addition, sloped portions 22 and 31 that are continuous with these finger pressing portions are formed, and these sloped portions are provided to gradually press the fingers 40 to 46 from the opened state to the closed position. It has been.
And the connection parts 23 and 36 are formed in the position where the fingers 40-46 open the tube 50, and each is formed on the concentric circle equidistant from the rotation center P. As shown in FIG. Further, the end portions of the finger pressing portions 21a, 21b, 21c, and 32 are connected to the connecting portions 23 and 36 by straight lines toward the rotation center P (represented by reference numerals 24 and 35 in the figure).

  The second cam 30 is pivotally supported by the cam drive wheel 76 and is in a loose-fitting relationship. However, the second cam 30 is rotated in the same direction (arrow R direction) by the first cam 20 fixed to the cam drive wheel 76. That is, the second cam 30 has the first cam engagement portion 38 engaged with the second cam engagement portion 26 of the first cam 20 and the rotational force of the first cam 20 is the second cam engagement portion. 26 is transmitted to the first cam engaging portion 38 and rotates together with the first cam 20.

Next, the shapes of the fingers 40 to 46 will be described with reference to FIG. Since the fingers 40 to 46 have the same shape, the finger 44 will be described as a representative. The fluid transport mechanism 2 shown in FIG. 4 shows the AA cut surface of FIG. In the finger 44, one end 44b of the shaft 44a is rounded into a semicircular shape, and a flange 44c is formed at the other end. The end portion 44b is a contact portion with the first cam 20 and the second cam 30, and the flange portion 44c is a tube pressing portion.
The fingers 40 to 46 are mounted in a finger guide groove 126 formed in the tube frame 12 so as to be reciprocally movable in the axial direction.

Then, the fluid flow effect | action of the fluid transport apparatus 1 is demonstrated with reference to FIG. FIG. 6 shows one state of the fluid transport device 1. In this state, the finger pressing portion 32 of the second cam 30 presses the finger 44, and the finger 44 closes the tube 50 (see also FIG. 4). The fingers 45, 46 are on the slope portion 31, and the finger 45 has a slightly smaller tube pressing amount than the finger 44, and the finger 46 has a smaller pressing amount.
The fingers 41 to 43 are in the region of the connecting portion 36 of the second cam 30 and open the tube 50. The finger 40 is in a position where it begins to ride on the inclined surface portion 22 of the first cam 20 and is in a state in which the tube 50 is slightly pressed. In such a state, in the region of the fingers 40 to 43, the chemical solution has entered the fluid flow portion 51 of the tube 50 from the reservoir 60.

Further, when the first cam 20 and the second cam 30 are rotated in the arrow R direction, the finger pressing portion 32 of the second cam sequentially closes the fingers 45 and 46. Then, the finger pressing portion 21 c of the first cam 20 is sequentially closed from the finger 40 toward the finger 46. The finger released from the finger pressing part 32 or the finger pressing part 21 c opens the tube 50. In this way, the fingers 40 to 46 are repeatedly closed and opened by the peristaltic motion of the fluid from the upstream side to the downstream side, and the liquid medicine flows from the reservoir 60 toward the outlet 53. In the present specification, a structure that causes such a fluid flow action is referred to as a micropump.
The tube 50 is held by a tube guide groove 121 formed in the tube frame 12 and a tube guide groove of the upper lid 13. 125 and 131 are formed in each of them, and a necessary space is formed when the tube 50 is closed and deformed. In FIG. 4, the state where the tube 50 is closed is indicated by a solid line, and the opened state is indicated by a two-dot chain line.

In addition, since the pitches and shapes of the finger pressing portions of the first cam 20 and the second cam 30 are the same and the fingers are equally spaced, the load torque applied to the cam driving wheel 76 is the cam driving wheel 76 ( The shape of the finger pressing portion and the slope portion is set so that the variation in load torque during one rotation of the first cam 20 and the second cam 30) is small and substantially constant.
As a specific example of the fluid transportation device 10 of the present invention, the outer diameter of the tube 50 is 1.1 mm, the diameter of the fluid flow part 51 is 0.6 mm, and the rotational speeds of the first cam 20 and the second cam 30 are as follows. When it is set to 4 rotations / hour, a continuous flow of 15 μl / hour of chemical solution is realized.
In addition, the size of the fluid transport device 1 is reduced to a width of 18 mm, a length of 32 mm, and a thickness of 8.5 mm.

Therefore, according to the first embodiment described above, components such as the fluid transport mechanism 2, the drive transmission mechanism 3, the battery 4, the valve 80, the reservoir 60, and the like are disposed in a housing (exterior case) including the upper lid 13 and the lower lid 16. Therefore, when the fluid transport device 1 is mounted in the living body, body fluid, blood, or the like does not enter the housing, and the fluid transport mechanism 2 and the drive transmission mechanism 3 are affected. And stable driving can be continued in the living body.
Further, by properly disposing the fluid transport mechanism 2, the drive transmission mechanism 3, the battery 4, the reservoir 60, and the valve 80 as described above, it is possible to achieve a reduction in size and thickness and to be mounted in the living body. It is possible.
In addition, since the fluid transport device 1 has no components that protrude outside the living body, including the tube 50, there is no occurrence of an infectious disease at the connection portion between the inside and outside of the living body, and can be used safely.
Further, since the valve 80 for injecting the fluid into the reservoir 60 is provided, the chemical liquid can be additionally injected at any timing even while the fluid transport device 1 is being driven. The continuous flow of the chemical solution can be continued without stopping.

Further, since the drive transmission mechanism 3 is composed of a watch movement, it is possible to reduce the size and thickness of the watch, and thus to reduce the thickness and size of the fluid transport device 1. Further, since the movement for a watch that is mass-produced including the cam drive vehicle 76 into which the first cam 20 and the second cam 30 are inserted is adopted, it contributes to cost reduction.
Further, since the valve 80 is disposed through the upper lid 13 in a planar space formed between the drive transmission mechanism 3 and the fluid transport mechanism 2, the chemical solution is injected from the valve 80 into the reservoir 60. In this case, there is no member that hinders the injection operation above the valve 80, and the injection operation can be easily performed. Furthermore, it is possible to inject the chemical solution from above the skin into the reservoir 60 with the fluid transport device 1 mounted in the living body, and when the chemical solution is additionally injected, there is no need to take out the fluid transport device and to the living body. Can be reduced.

The chemical solution in the reservoir 60 flows from the fluid inlet port 62 communicating with the valve 80 toward the fluid inlet port 52 communicating with the tube 50. Therefore, by disposing the fluid inlet port 62 on the upstream side and the fluid inlet port 52 on the downstream side, it is possible to suppress the occurrence of vortex flow and pulsating flow of the chemical solution in the reservoir 60, A predetermined flow rate and a stable continuous flow can be maintained.
Furthermore, since the reservoir 60 is configured by a deformable wrapping bag, the volume of the reservoir 60 is deformed so that the volume of the reservoir 60 is reduced as the internal pressure decreases due to the flow of the chemical solution. I can keep it. Accordingly, when the tube 50 is closed by the fingers 40 to 46 and then opened, the fluid fluidized portion 51 in the opened region is filled with the chemical solution, so that stable fluid flow can be maintained.

Further, the planar shape of the casing (exterior case) composed of the upper lid 13 and the lower lid 16 is an oval shape, the outer peripheral portion is formed in a gentle streamline shape, and the outflow side end of the fluid of the tube 50 is However, since it extends along the outer peripheral shape of the casing, when the fluid transport device 1 is mounted in the living body, the living tissue and the casing and the tube 50 The biocompatibility is improved, and the housing can damage the living tissue or suppress a sense of discomfort to be worn.
Furthermore, the injection needle can be easily inserted into the slit 82b of the fluid injection plug 82 that is press-fitted into the valve 80, and when the injection needle is removed after the fluid is injected into the reservoir 60, the fluid injection plug 82 is removed. It is possible to prevent the fluid from flowing out of the valve by closing the slit by its own elastic force. Such a valve can realize a simple structure that does not use a valve or the like, and has an effect that a fluid injection operation can be repeated.

[Second Embodiment]
FIGS. 7 to 9 show a fluid transportation device according to a second embodiment of the present invention. FIG. 7 shows a configuration in the plane direction, FIG. 8 shows a configuration in the thickness direction, and (A) is viewed from the narrow side. 9B is a view from the wide side, FIG. 9 is a reservoir frame, FIG. 9A is a plan view, FIG. 9B is a front view, and FIG. 9C is a side view. In the present embodiment, a point in which a fluid transport device that is attached to a living body such as a human body or an animal and uses a chemical as a fluid is illustrated and described, or the fluid includes a gel-like fluid, and gas is also contained. The points to include are the same as in the first embodiment.

  The fluid transport device 160 shown in the second embodiment of FIGS. 7 and 8 is different from the fluid transport device 1 of the first embodiment in that a reservoir 170 is attached to the outside of the exterior case 161 and the reservoir 170. Are mainly attached to the exterior case in an inclined manner, and the reservoir 170 is attached to the exterior case via the reservoir frame 180. In addition, a fluid transport mechanism (micropump) 162 including a first cam 163, a second cam 164, a tube 165, and seven fingers 166, and a liquid injection port (port) 167 having a fluid injection plug 168 are the first. This is the same as that shown in the embodiment, and the description is omitted. Further, a drive transmission mechanism, a circuit board, a battery, and the like (not shown) are the same as those in the first embodiment, and a description thereof is omitted. The outer case 161 has an attachment portion 192 for attaching to an installation target such as subcutaneous. The attachment portion 192 is used for sewing with a thread or the like, for example, and is used in the same manner as in the embodiments described later.

As shown in the figure, the reservoir 170 is formed of a thin-walled sachet that can swell when filled with a chemical solution and reduce its volume when the chemical solution flows out, and has a circular shape in plan view. The one having a shape in which the thickness is increased and the thickness is decreased toward the periphery. However, the shape of the reservoir 170 is not limited to the illustrated shape, and may be a shape having a flat bottom surface, for example.
The reservoir 170 is held by the outer case 161 via the reservoir frame 180 and has a fluid inlet 171 connected to the liquid injection port 167 and a fluid outlet 172 connected to the tube 165. Yes. In addition, in order to connect the reservoir 170 outside the exterior case 161 to the tube 165 in the exterior case 161, both are connected via the connection member 173, and the exterior case 161 and the connection member 173 are sealed to seal the exterior case. The sealing property in 161 is ensured.

As shown in FIG. 8B, the exterior case 161 is formed such that the portion to which the reservoir 170 is attached is formed with a low height by the step 161a at the portion of the liquid injection port 167 when viewed from the wide direction. Following this stepped portion 161a, an inclined portion 169 is formed such that the height decreases toward the end at an angle X. Although the illustrated angle X is set to 17 degrees, it is not limited to this and can be set arbitrarily. The inclined portion 169 has an opening 190 described later.
The reservoir 170 is held via the reservoir frame 180 so as to follow the inclination of the inclined portion 169, and the reservoir 170 itself is also inclined at an angle X as shown in FIG. Thus, by tilting the reservoir 170, it is possible to prevent the skin from being stretched by the end of the fluid transport device 160 when the reservoir 170 is implanted under the skin of an animal or the like. Therefore, the inclination angle of the reservoir 170, that is, the angle X of the inclined portion may be an angle that can suppress the skin tension, and can be set to a suitable angle according to the installation condition, for example, 10 degrees to 30 degrees. Moreover, it is not limited to inclining linearly like illustration, You may incline curvedly.

As shown in FIG. 9, the reservoir frame 180 has a substantially cylindrical shape having a curved bottom portion 180a, and a notch 180b and a notch 180c are formed by notching a part of the wall portion. As shown in FIG. 7, the notch 180 b is used to pass a tubular fluid inlet 171 extending from the reservoir 170, and the notch 180 is formed through the tubular fluid outlet 172 also extending from the reservoir 170. Used for threading. The reservoir frame 180 is formed of a hard material such as resin or metal, but is not particularly limited.
The reservoir 170 and the reservoir frame 180 are integrated by fixing the lower surface 170a and the bottom portion 180a with an adhesive or the like. The means for fixing is not limited to an adhesive. Further, as shown in the figure, the reservoir 170 and the reservoir frame 180 are formed separately and are not limited to being integrated thereafter, and the same material can be used to form the lower surface side hard and the upper surface side soft. If there is, it can also be formed integrally. In this case, the hard portion on the lower surface side corresponds to the reservoir frame 180 of the present embodiment, and the soft portion on the upper surface side corresponds to the reservoir 170.

The bottom portion 180a of the reservoir frame 180 is formed so as to correspond to the shape of the lower surface 170a of the reservoir 170, and is formed, for example, with the same curvature as that of the lower surface 170a. Further, the center of the bottom portion 180a is shifted so that the reservoir 170 is inclined at an angle X1 when the reservoir 170 is fixed. The angle X1 is set in association with the inclined portion X of the outer case 160 described above, but is not limited to this.
Since the bottom portion 180a is formed corresponding to the shape of the lower surface 170a of the reservoir 170, for example, when the lower surface 170a is flat, the bottom portion 180a is also formed flat.

  Further, as shown in FIG. 9, the reservoir frame 180 is provided with a pair of hooks 181 at positions opposed to the outer peripheral surface. The hooks 181 are formed so as to protrude outward from the upper end of the reservoir frame 180 and bend downward. The hooks 181 are provided at the lower ends of the hooks 181 with flanges 183 that protrude substantially horizontally toward the outside. And a guide surface 182 that extends downward from the outer tip of the flange 183 and inclines inward. That is, the lower end portion (including the flange portion 183 and the guide surface 182) of the hook 181 is held from the outer peripheral surface of the reservoir frame 181 through a gap. The hook 181 is formed integrally with the reservoir frame 180, and is given elasticity so that the lower end portion including the flange portion 183 can be bent inward.

On the other hand, as shown in FIGS. 7 and 8, the exterior case 161 is provided with an opening 190 for attaching the reservoir frame 180 to the inclined portion 169. The opening 190 is formed to have an inner diameter capable of fitting the reservoir frame 180, and a pair of step portions 191 for latching the flange portion 183 of the hook 181 when the reservoir frame 180 is fitted to the inner wall lower portion thereof. Is formed. The exterior case 161 is formed so that the height of the opening 190 portion gradually decreases.
In the fluid transport device 160 configured as described above, the operation (action) of discharging the fluid accommodated in the reservoir 170 to the outside, and the procedure for replenishing the reservoir 170 with the fluid are the fluids of the first embodiment. The same as the transport device 1.

Next, an assembly method around the reservoir 170 will be described with respect to the second embodiment. First, the reservoir 170 integrated with the reservoir frame 180 is prepared. Subsequently, the fluid inlet port 171 of the reservoir 170 is connected to the liquid injection port 167, and the fluid outlet port 172 of the reservoir 170 is connected to the tube 165 (connecting member 173). At the same time as this connection work, the reservoir frame 180 is fitted into the opening 190. At this time, the hook 181 is in a state where the lower end portion is bent inward by the guide surface 182 being guided inward at the upper end of the opening 190. The hook 181 proceeds downward with its lower end portion bent inward, and returns to its original state due to its own elasticity when the flange portion 183 reaches the step portion 191. As a result, the collar portion 183 is hooked on the stepped portion, and the reservoir 170 is held by the exterior case 161 via the reservoir frame 180. Note that when the reservoir 170 is removed for replacement or the like, the procedure is reversed.
After the assembly, it is preferable that the surface of the reservoir 170 and the entire product (the entire fluid transportation device 160) is subjected to a silicon coating process to ensure more non-toxicity.

Thus, according to the second embodiment, since the reservoir 170 is attached to the outside of the outer case 161, it is possible to avoid the influence on the drive transmission mechanism and the battery even when condensation occurs on the surface of the reservoir 170. Durability can be improved by suppressing the occurrence of rust and circuit defects.
Furthermore, since the reservoir 170 is held in an inclined state on the surface of the outer case 161, for example, when the fluid transport device 160 is implanted subcutaneously, the skin is not stretched at the end of the reservoir 170. It is possible to reduce discomfort after wearing.
Further, since the reservoir 170 is attached in a detachable state via the reservoir frame 180, the reservoir 170 can be securely held at a predetermined position of the outer case 161, and workability such as replacement can be improved.
Further, when the fluid transport device 160 is implanted subcutaneously, the lower side of the reservoir 170 is protected by a hard reservoir frame 180 and the upper side is opened, whereby the reservoir 170 can be easily deformed. .

  Moreover, this 2nd Embodiment shows an example which hold | maintains the reservoir | reserver 170 on the outer side of the exterior case 161, and is not limited to the form shown in FIGS. For example, the reservoir 170 may be directly attached to the outer surface of the outer case 161 without using the reservoir frame 180. In this case, the reservoir 170 is fixed to the surface of the outer case 161 with an adhesive or the like.

Moreover, as shown in FIG. 8, it is not limited to inclining the reservoir 170. That is, the upper surface may be flattened without providing the inclined portion 169 in the exterior case 161, and the reservoir 170 may be held in a flat state on the flat surface.
Further, the liquid injection port 167 may be formed in a part of the reservoir frame 180 instead of being provided in the outer case 161, and further, a part of the upper surface of the reservoir 170, for example, the central part of the upper surface of the reservoir 170 or the fluid You may provide in the part away from the discharge port part 172, etc.
Further, the means for attaching / detaching the reservoir frame 180 to / from the outer case 161 is not limited to using the hook 181 and the step portion 191, and the reservoir frame 180 may be fixed to the outer case 161 using, for example, screws.

[Third Embodiment]
3rd Embodiment of this invention shows the chemical | medical solution supply apparatus (fluid transport apparatus) for implanting under the skin of a laboratory animal. A chemical solution is used as a fluid, and the object to be installed is an experimental animal. A laboratory animal refers to a small animal that can perform animal experiments on chemicals such as mice, rats, and guinea pigs. The chemical liquid refers to, for example, medicinal liquids and nutrient liquids, and refers to all liquids for performing animal experiments and animal treatments for their development.

  FIG. 10 shows an outline view of a chemical solution supply apparatus for implantation under the skin of a laboratory animal. 10A is a side view seen from the bottom of the chemical liquid supply device as viewed from below, and is a side view seen from the front side of the paper of FIG. 12, and FIG. FIG. 10C is a side view seen from the right side of the medicinal solution supply device, and FIG. 10D is a medicinal solution supply device. It is the left view side view seen from the left. FIG. 11 is an enlarged view of the right side of FIG. 10A in the chemical liquid supply apparatus of the present invention, and is also a side view of a thread hook portion that is sewn to the experimental animal with a thread when the chemical liquid supply apparatus is embedded in the experimental animal. is there. FIG. 12 is a plan view of the present chemical solution supply device, as seen from above in FIG. 10 (A). 13 is a cross-sectional view of the main part at the position A1-A1 in FIG. 14 is a cross-sectional view of the main part at the BB position in FIG. FIG. 15 is a cross-sectional view of the main part of the micropump portion of FIG. FIG. 16 is an enlarged cross-sectional view of the liquid injection port.

First, the appearance of the chemical solution supply apparatus 201 will be described.
In FIG. 10, the chemical solution supply apparatus 201 for implantation under the skin of a laboratory animal has a substantially box shape in appearance. The lateral width dimension in the longitudinal direction is approximately 34 mm, the depth dimension in the narrow width direction (short direction) is approximately 18 mm, and the height dimension is approximately 8.5 mm.
As an exterior case, an upper lid 202, a lower lid 203, an upper base frame (corresponding to the tube frame 12 of the first embodiment) 204, and a lower base frame (corresponding to the movement frame 15 of the first embodiment) 205 are fixed to each other. . The surface of the upper lid 202 is a skin-side corresponding surface that corresponds to the skin side when implanted under the skin, and the surface of the lower lid 203 is the back surface of the skin-side corresponding surface. The material of the member that contacts the experimental animal such as the upper lid 202, the lower lid 203, the upper base frame 204, the lower base frame 205, etc. needs to be nontoxic to the experimental animal. In addition, since the member is also a functional member, high strength and high hardness are required. Therefore, the materials of the upper lid 202, the lower lid 203, the upper base frame 204, the lower base frame 205 and the like as the outer case are non-toxic to the experimental animal, have high strength and high hardness, and are preferably lightweight. Synthetic resins such as polypropylene, polystyrene, and polycarbonate are used. After assembling, it is preferable to ensure non-toxicity by performing a silicon coating treatment. In addition, you may make it select the above-mentioned material from a viewpoint of ensuring biocompatibility.
The upper lid 202 is made of a transparent material, and can easily identify whether the built-in structure or the assembled state and the operating state of the parts are normal or abnormal. The lower lid 203, the upper base frame 204, and the lower base frame 205 as other exterior case members are made of a non-transparent colored resin.

  The upper lid 202, the lower lid 203, the upper base frame 204, and the lower base frame 205 have a function of storing and holding a built-in member. This is a member for holding the reservoir 209. Since the reservoir 209 expands and contracts as described above, for example, the reservoir 209 slides somewhat between the upper lid 202, the lower lid 203, the upper base frame 204, and the lower base frame 205. As will be described later, since the arcuate tube portion 211a of the tube 211 is sequentially pressed by a plurality of pressing pins 218, the upper lid 202 holding the pressed arcuate tube portion 211a on the side wall and The pressing force acts on the upper base frame 204, and the arcuate tube portion 211a slides somewhat between its side walls as the arcuate tube portion 211a expands and contracts.

  Therefore, members having a function of storing and holding the built-in member, for example, the upper lid 202, the lower lid 203, the upper base frame 204, and the lower base frame 205 are required to have high strength and low friction coefficient. Yes. Therefore, for example, a member having a function of storing and holding the built-in member such as the upper lid 202, the lower lid 203, the upper base frame 204, the lower base frame 205, or the like is filled with a filler that contributes to low friction. You may make it do.

  As will be described later, in FIG. 15, an arcuate tube portion support wall 224 a constituting a tube storage portion 224 that stores the arcuate tube portion 211 a of the micropump 212 is formed by an upper lid 202 and an upper base frame 204. In this arcuate tube portion support wall 224a, since the pressing pin 218 sequentially presses the arcuate tube portion 211a, the arcuate tube portion support wall 224a receives this pressing force. Therefore, the upper lid 202 and the upper base frame 204 constituting the arcuate tube portion support wall 224a may be filled with a filler that contributes to high strength and low friction. Therefore, even when the arcuate tube portion 211a is pressed by the pressing pin 218, the arcuate tube portion support wall 224a is not deformed, and a stable liquid pump for supplying a chemical solution that does not change with time can be provided.

Now, the external shape of the chemical solution supply apparatus 201 is as follows.
As shown in FIG. 10A, the left and right side surfaces in the longitudinal direction of the chemical liquid supply apparatus 201 are inclined surfaces such that the longitudinal dimension of the chemical liquid supply apparatus 201 becomes narrower as it goes upward. In FIG. 10A, a left end long left inclined surface 201d and a right end long right inclined surface 201e are formed. When the inclined surfaces 201d and 201e are implanted under the skin of the experimental animal, the skin of the experimental animal is pulled according to the volume and height of the chemical solution supply device 201, and in the worst case, the skin is damaged. Become. Therefore, the inclined surfaces 201d and 201e are formed so that the pulling is as small as possible and a local shearing force is not applied to the skin.
The inclination angles α1 and α2 of the inclined surfaces 201d and 201e are preferably 5 to 60 degrees, and more preferably 15 to 30 degrees. The inclination angles α1 and α2 of the inclined surfaces 201d and 201e may be the same or different.

The side surfaces in the narrow width direction of the chemical solution supply apparatus 201 illustrated in FIGS. 10C and 10D do not have to be provided with the inclined surfaces as described above, but the width is narrowed toward the upper side. In (C), a left-side width left inclined surface 201f and a right-end width right inclined surface 201g in the narrow width direction are formed. The inclination angles β1 and β2 of the inclined surfaces 201f and 201g are preferably 5 to 45 degrees, and more preferably 10 to 30 degrees. The inclination angles β1 and β2 may be the same or different.
The inclination angle is preferably larger from the viewpoint of reducing the skin tension of the experimental animal. However, the internal space of the chemical solution supply device 201 and the efficient arrangement of the built-in members, and the chemical solution supply device 201 at the initial injection of the chemical solution From the viewpoint of being easily held and held by hand, the smaller one is preferable.

When viewed from the side (as viewed from the side), the upper, lower, left and right corners are formed in an arc shape so as not to damage the subcutaneous part of the experimental animal.
As shown in FIG. 10A, the left and right corners in the longitudinal direction of the lower lid 203 have a large arc shape, and the width of the lower lid 203 is shown in FIG. The left and right corners in the narrow width direction are formed in a large arc shape. Similarly, as shown in FIG. 10A, the left and right corners in the longitudinal direction of the upper lid 202 are formed in a large arc shape, and as shown in FIG. 10C, the left and right corners in the narrow width direction of the upper lid 202 are formed. Is formed in a large arc shape. The arc-shaped portion in the longitudinal direction is formed in an arc shape having a larger radius than the arc-shaped portion in the narrow width direction, and the arc-shaped portions of the lower lid 203 are arc-shaped having a larger radius than the arc-shaped portion of the upper lid 202, respectively. Is formed. Note that the size of the radius may be opposite to that described above, or may be an arc having substantially the same radius.

10 (C), (D) and FIG. 8, the chemical solution supply device 201 is sewn to the experimental animal (installation target) under the skin of the experimental animal with a thread to fix the thread. A thread hook portion 207 that is an attachment portion for passing the thread is formed so as to protrude at a plurality of locations. The thread hook portion 207 is provided with a hole 207a for passing a thread.
The yarn hooking portion 207 is formed to protrude from the side surface of the lower lid 203, and is located at a predetermined height h1 from the bottom surface of the lower lid 203 to the lower surface of the yarn hooking portion 207. This predetermined height h1 is 1/10 to 1/2, preferably 1/5 to 1/3 of the thickness of the chemical solution supply apparatus 201, that is, the thickness H from the upper surface of the upper lid 202 to the lower surface of the lower lid 203. It is preferable to be formed in the position. That is, since the thread hook 207 has the height h1 described above, when the chemical solution supply device 201 is sewn and fixed to the experimental animal with a thread, the sewing portion of the experimental animal is attached to the thread hook 207. It is because it can be set to the approaching planar view position, and the chemical solution supply device 201 can be drawn right below, and can be attached so as not to float more.

The yarn hooking portion 207 may be formed so as to protrude from the side surface of the lower base frame 205. In this case, the yarn hooking portion 207 may be at a position where the predetermined height h1 is secured, or may be formed so as to protrude in the plan view direction from the lower surface of the lower lid 203 which is the bottom surface of the chemical solution supply apparatus 201.
Further, the position in plan view where the yarn hooking portion 207 is formed is the left and right side portions of the chemical solution supply apparatus 201 as shown in FIG. In other words, on the right side, there are three diameters in the vicinity of the portion where the tube 211 protrudes to the outside, two places on the upper side, and one place near the center of the left side.
Note that the thread hooking portion 207 moves the protruding portion of the tube 211 protruding from the side surface of the chemical solution supply apparatus 201 if the yarn hooking portion 207 is located on both sides of the protruding position of the tube 211 in the formation portion of the right side surface. Therefore, the chemical solution can be stably supplied to the experimental animal without moving the catheter for supplying the chemical solution to the experimental animal.

The formation place of the yarn hooking portion 207 in a plan view is preferably inside the quadrilateral in contact with the maximum outer shape end of the outer case as shown in FIG. The quadrilateral in contact with the maximum outer edge of the outer case is designated as follows in FIG. That is, the longitudinal tangent e1 of the upper end constituting the maximum width of the exterior case in the longitudinal direction of the chemical solution supply apparatus 201 and the longitudinal tangent e2 of the lower end constituting the maximum width of the exterior case in the longitudinal direction The longitudinal direction is the narrow-width-direction tangent line e3 that forms the maximum width of the exterior case in the narrow-width direction in the orthogonal direction, and the outer-width of the exterior case in the narrow-width direction (short direction). A quadrilateral is drawn by the narrow-width-direction tangent line e4 at the left end constituting the large portion. Each of the thread hooks 207 is arranged in a quadrilateral surrounded by the e1, e2, e3, e4 in plan view.
As described above, the yarn hooking portions 207 are arranged in the quadrilateral in a plan view, so that the yarn hooking portions 207 do not jump out of the side surface of the exterior case. The hanging portion 207 prevents the experimental animal from being pressed unnecessarily, thereby damaging the experimental animal and causing discomfort. In particular, since each of the thread hooks 7 is likely to be formed in a protruding shape, it is likely to press the experimental animal locally, and it is easy to cause the damage. This is an effective means for preventing the problem.
As shown in FIG. 10A, the tube 211b protrudes from the side.
In this embodiment, the thread hooking portion 207 is used as the attachment portion, but the present invention is not limited to this. For example, instead of sewing the object to be installed with a thread, it may be fixed with staples or an adhesive, and the attachment portion in that case is formed in a shape suitable for fixing with staples or an adhesive.

Next, FIG. 12 shows a plan view of the chemical liquid supply apparatus 201 in a plan view (when the chemical liquid supply apparatus 201 is viewed from above in FIG. 10A). The outline of the planar layout will be described with reference to this plan view. That is, an outline of the overall layout of the chemical solution supply apparatus 201 will be described.
In FIG. 12, a liquid injection port 208 (hereinafter referred to as a liquid injection port in this embodiment) as a port through which a chemical liquid is injected into the chemical liquid injection device 201 from the outside is provided at the upper part of the center. A reservoir 209 communicating with the liquid port 208 and storing a chemical solution therein; a flat circular battery 210 (silver oxide battery) partially overlapping the reservoir 209 and disposed in the lower right direction of the reservoir 209; A tube 211 (medical solution conducting portion) that is arranged substantially on the right side of the entire chemical solution injecting device and has elasticity to communicate with the reservoir 209 and to conduct the chemical solution; a micropump 212 that is configured near the substantially central portion of the tube 211; An integrated circuit (IC) 225 (see FIG. 13) having a driving circuit for the micropump 212 and a driving control circuit for controlling the driving circuit, and the IC And depending on finely necessary circuit board ensure electrical connections between the place any electronic device and the electronic components 226 (see FIG. 13) constitutes at least a by-chip unit.

The liquid injection port 208 is positioned substantially at the center in the longitudinal direction (left and right direction in FIG. 12) of the chemical liquid injector 201 and is narrow in the width direction (short direction) (vertical direction in FIG. 12 and perpendicular to the longitudinal direction). Is disposed between the reservoir 209 and the micropump 212, and is disposed so as not to overlap the battery 210 in plan view.
The micropump 212 is radially disposed outside the rotation drive unit 214, the cam unit 217 including the first cam 215 and the second cam 216 rotated by the rotation drive unit 214, and the cam unit 217. The cam portion 217 has a plurality of pressing pins 218 that sequentially project outward, and an arcuate tube portion 211 a that is formed in an arc shape at substantially the center of the tube 211.

The rotation driving unit 214 of the micro pump 212 partially overlaps the battery 210 on the left side, but does not overlap the reservoir 209.
Further, the cam portion 217 and the pressing pin 218 of the micropump 212 do not overlap the liquid injection port 208, the reservoir 209, the battery 210, and the tube 211 in a plan view.
The right end portion of the tube 211 is an exposed tube portion 211b protruding outside the chemical solution supply apparatus 201, and a catheter (not shown) is attached to the tip of the exposed tube portion 211b. A chemical solution is injected into the body.

By fixing the upper lid 202, the lower lid 203, the upper base frame 204, and the lower base frame 205 as the above-described outer case with a plurality of outer case fixing screws 213, the built-in portion has a planar direction and a cross-sectional direction. Is supported by As shown in FIG. 12, the outer case fixing screws 213 are screwed into the guide legs 219 from the upper part of the upper cover 202 and the lower part of the lower cover 203 at four locations on the outer periphery of the chemical solution supply apparatus 201. It is included. The upper lid 202, the lower lid 203, the upper base frame 204, and the lower base frame 205 have their planar positions determined by inserting their guide holes into the guide support legs 219. The upper cover 202, the lower cover 203, the upper base frame 204, and the lower base frame 205 are positioned and fixed in the cross-sectional direction (thickness direction) by tightening the upper and lower outer case fixing screws 213.
The above is an overview of the overall layout.

Next, the schematic cross-sectional structure of the chemical solution supply apparatus 201, the detailed structure and materials of the main part will be described based on FIG. 11, FIG. 12, FIG. 13, FIG.
First, as described above, the upper lid 202, the lower lid 203, the upper base frame 204, and the lower base frame 205 are positioned and fixed in the cross-sectional direction by screwing the outer case fixing screw 213 from both the upper and lower sides in the cross-sectional direction. . As the exterior case, only the upper lid 202 and the lower lid 203 may be provided. In this case, the upper base frame 204 and the lower base frame 205 are not exposed to the outer peripheral side surface, and the side wall formed by the upper lid 202 and the lower lid 203 is used. It will be placed inside.

First, the liquid injection port 208 is configured as follows.
The liquid injection port 208 is configured on the upper surface side of the upper lid 202 and is disposed toward the skin side of the experimental animal when the drug solution supply device 201 is implanted subcutaneously.
A substantially circular cylindrical liquid injection port protrusion 208a is formed on the upper surface of the upper lid 202, and an injection opening 208b for introducing a liquid injection tool to be inserted from the outside is provided inside the upper cover 202. It has been. This liquid injection tool is in the form of an injection needle, and is used to replenish the reservoir 209 with a chemical solution. The liquid injection port protrusion 208 a is formed integrally with the upper lid 202 and is made of the same material as the upper lid 202.
The liquid injection port protrusion 208a has the following dimensions. As shown in FIG. 16, the outer diameter d1 of the tip (upper end) of the liquid injection port projection 208a is approximately 6.0 mm, and the height h2 from the upper surface of the upper lid 202 to the tip of the liquid injection port projection 208a. Is approximately 1.5 mm. An inclined surface 208c having a divergent taper from the tip of the liquid injection port protrusion 208a to the upper surface of the upper lid 202 is formed. It is designed not to damage experimental animals. An inner diameter d2 of the injection opening 208b formed inward thereof is approximately 4.0 mm. The outer diameter d3 of the liquid injection port packing 221 below that is 3.0 mm. The diameter d4 of the lower space 220a is 2.3 mm.

  Since the liquid injection port protrusion 208a of the liquid injection port 208 protrudes from the upper surface of the upper lid 202, it is embedded under the skin of a laboratory animal and the location of the liquid injection port 208 can be easily recognized from the outside. That is, after the chemical solution supply apparatus 201 is implanted under the skin of the experimental animal, the chemical solution is gradually sent out into the body of the experimental animal by the operation of the micropump 212, and eventually the chemical solution stored in the reservoir 209 is reduced. An experimenter of an animal experiment inserts a liquid injection tool from the outside of the experimental animal into the liquid injection port packing 221 of the liquid injection port 208 and supplies the chemical solution into the reservoir 209. At that time, the experimenter needs to accurately recognize the location of the injection opening 208b of the liquid injection port 208 from the outside of the experimental animal. However, the injection port 208 of the present embodiment is such that the injection port protrusion 208a protrudes from the upper surface of the upper lid 202 as described above, so that the epidermis of the experimental animal is locally swelled. The location of the liquid injection port 208 can be easily recognized. Accordingly, when the experimenter inserts the liquid injection tool into the center of the swelled portion of the skin, the liquid injection tool can be inserted into the liquid injection port packing 221 and the chemical solution can be supplied into the reservoir 208. It is.

  As described above, the injection port protrusion 208a protrudes from the upper surface of the upper lid 202, and the epidermis of the experimental animal rises locally so that the experimenter can recognize the location of the injection port 208. Each dimension of 208a is preferably in the following range. That is, as shown in FIG. 16, the outer diameter d1 of the tip (upper end) of the liquid injection port protrusion 208a is 4.0 mm to 8.0 mm, more preferably 5.0 mm to 7.0 mm. The height h2 to the tip of the injection port protrusion 208a is 0.5 mm to 2.5 mm, more preferably 1.0 mm to 2.0 mm, and the inclination angle γ of the inclined surface 208c is 5 degrees to 60 degrees. Preferably, it is 15 degrees to 45 degrees. Further, the inner diameter d2 of the injection opening 208b formed inward is 2.0 mm to 6.0 mm, more preferably 3.0 mm to 5.0 mm.

A liquid injection port frame 220 made of a synthetic resin such as polypropylene or ABS resin is disposed below the injection opening 208b from the viewpoint of chemical resistance against chemicals and strength. A central portion of the liquid injection port frame 220 is opened, and a liquid injection port packing 221 made of synthetic rubber such as silicon having elasticity can be secured to the contact surface of the liquid injection port frame 220 in the opening. Joined and held with an adhesive. The above-mentioned liquid injection port packing 221 is easy to insert a liquid injection tool inserted from the outside and is easy to be removed. It is necessary to have elasticity that can reliably prevent animal body fluids from entering the inside. Therefore, it is necessary to carefully select the diameter and thickness of the liquid injection port packing 221 together with the appropriate elasticity described above. In addition, from the viewpoint of non-toxicity to laboratory animals, biocompatibility, and chemical resistance to chemical solutions, the material of the injection port packing 221 is preferably silicon.
The liquid injection port frame 220 is formed with a space portion 220 a on the lower inner side of the liquid injection port packing 221, and subsequently, a pipe-shaped connecting cylinder portion 220 b protruding toward the side wall of the reservoir 209. A communication path 220c that communicates with the space 220a is formed on the center side of the connection cylinder 220b.

The reservoir 209 has a bag shape capable of storing a chemical solution therein, and is made of a thin, deformable synthetic resin having a thickness of approximately 0.2 mm. When the chemical liquid is discharged by the micro pump 212 and discharged from the reservoir 209, the reservoir 209 contracts, and when the chemical liquid is injected from the liquid injection port 208, the reservoir 209 expands. The plan view shape and the side view shape of the expanded reservoir 209 having the maximum shape are as shown in the drawings.
The material of the reservoir 209 is preferably a material having chemical resistance against chemicals, elasticity, and strength, and excellent gas barrier properties (property of gas permeation), and among them, a synthetic resin material is preferable. The material having excellent gas barrier properties is required to prevent the entry of gas such as air from the outside into the chemical liquid of the reservoir 209 and prevent the harmful liquid from being mixed into the chemical liquid. This is to prevent the deterioration of the function of the micropump 212 because the pump function of the micropump 212 is lowered when bubbles enter and bubbles are present. For this reason, it is excellent in chemical resistance, elasticity, high strength, and gas barrier properties, and requires a rubber hardness of about 25 to 40 degrees. As the synthetic resin, olefin-based, vinyl chloride-based, silicon-based Synthetic resins are preferred.
As can be seen in FIG. 12, the planar view shape of the reservoir 209 is generally semicircular. However, as shown in FIGS. 10 and 11, a lower portion corresponding to a region overlapping in the plan view of the battery 210 is formed to have a small thickness in a cross-sectional view in order to avoid the battery 210.

In FIG. 12, on the right side of the upper portion of the reservoir 209, there is a liquid injection port connection portion 209a that has a shape protruding toward the liquid injection port 208 side and joins the connection pipe portion 220b of the liquid injection port 208. Is formed. On the right side of the lower portion of the reservoir 209, a connection pipe connection portion 209b protruding rightward is formed for connection to the connection pipe 222 connected to the tube 211. A chemical storage part 209c is provided between the liquid injection port connection part 209a and the connection pipe connection part 209b. The liquid injection port connection portion 209a and the connection tube portion 220b of the liquid injection port frame 220 may be joined by an adhesive or may be heat fusion by heating after press-fitting. The connection pipe connection portion 209b and the connection pipe 222 may be joined by an adhesive as described above, or may be heat fusion by heating after press-fitting.
The connection pipe 222 is preferably made of a metal such as stainless steel or a synthetic resin such as polypropylene or vinyl chloride from the viewpoint of gas resistance and chemical resistance against chemicals and strong, and has one end on the reservoir 209 side and one on the tube 211 side. At the other end, a step portion having a slightly larger outer diameter is formed so that the connection pipe connection portion 209b and the connection pipe attachment portion 211c of the tube 211 can be easily joined. On the center side of the connection pipe 222, a chemical liquid conduction path through which the chemical liquid can pass is formed.

  The tube 211 is preferably made of a material having chemical resistance against chemicals, elasticity and strength, and excellent gas barrier properties (property of gas permeation), and among them, a synthetic resin material is preferable. The material with excellent gas barrier properties is required in order to prevent the entry of gas such as air from the outside into the chemical solution in the tube and prevent harmful substances from being mixed into the chemical solution. This is because the pump function of the micropump 212 is reduced when bubbles enter and air bubbles are present, so that the function deterioration is prevented. The tube 211 is also a constituent member of the micropump 212. As will be described later, a rubber hardness (Shore A) of about 25 to 40 degrees is required so that the tube 211 does not break even when pressed by the pressing pin 218. To do. As the synthetic resin having excellent chemical resistance, elasticity, high strength and gas barrier properties and suitable hardness, olefin-based, vinyl chloride-based, and silicon-based synthetic resins are preferable. Therefore, the same material as that of the reservoir 209 can be selected. The tube 211 selected from these synthetic resins has an outer diameter of approximately 1.1 mm and an inner diameter of 0.6 mm. Therefore, the thickness is approximately 0.25 mm. It should be noted that the outer diameter, inner diameter, and thickness of the tube 211 can be changed as appropriate according to the usage conditions.

The shape in plan view is generally semicircular as shown in FIG. 12, and the arcuate tube portion 211a described above is formed on the substantially central side, and the exposed tube portion 211b described above is formed on the right side. A connection pipe attachment portion 211c that connects to the connection pipe 222 is formed on the reservoir 209 side on the left side.
In addition, the tube 211 is arranged at the upper part of the rotation driving unit 214 of the micropump 212 in the cross-sectional view direction, and is arranged at almost the same height as the cam unit 217 and the pressing pin 218. Has been.
Further, the upper lid 202 and the upper base frame 204 are formed in an arc shape formed on the corresponding outer portion of the arcuate tube portion 211a in a plan view with the same radius as the outer shape of the arcuate tube portion 211a of the tube 211 The tube storage portion 224 is formed, and the outer wall of the tube storage portion 224 is the arcuate tube portion support wall 224a, and is configured to support the outer wall of the arcuate tube portion 211a. The arcuate tube portion support wall 224a is configured as a straight wall in the vertical direction as shown in FIG. Accordingly, when the arcuate tube portion 211a is pressed outward by the pressing pin 218 of the micropump 212, the arcuate tube portion support wall 224a prevents the arcuate tube portion 211a from moving outward. The chemical solution conduction path inside the tube portion 211a can be almost sealed.
As described above, in FIG. 12, the pressing pin 218 sequentially presses the arcuate tube portion 211a by the cam portion 217, so that the chemical solution in the tube 211 is discharged to the exposed tube portion 211b side.

The tube storage portion 224 may be configured by only one of the upper lid 202 and the upper base frame 204. In this case, the arcuate tube portion support wall 224a is also formed by either one of the circular shape. Since there is no step at the seamed portion of the arcuate tube portion support wall 224a, the arcuate tube portion 211a can be more tightly pressed by pressing the pressing pin 218.
Further, the exposed tube portion 211b at the right end of the tube 211 protrudes to the outside from a tube exposure opening 223 provided on the right side wall of the upper lid 202 and the upper base frame 204. A catheter for injecting a drug solution into a blood vessel of a test animal or a predetermined part in the body is attached to the tip protruding outside from the tube exposure opening 223.
In addition, what is exposed outside from the tube exposure opening 223 may not be a tube. In that case, for example, the end of the tube 211 and a catheter (not shown) are connected inside the tube exposure opening 223, and the tip of the catheter is projected from the tube exposure opening 223 to the outside. The drug solution is supplied to the blood vessel of the experimental animal at the distal end side of the catheter.
The connection pipe attachment portion 211c is fitted into the outer shape of the connection pipe 222 and fixed by adhesion or thermocompression bonding.
The arcuate tube portion 211a is formed in an arc shape in a plan view, and is disposed so as to surround the above-described many pressing pins 218 and cam portions 217 arranged on the arc center side in the plan view. .

The micro pump 212 will be described.
The micropump 212 includes the arc-shaped tube portion 211a, the plurality of pressing pins 218, the cam portion 217, and the rotation driving portion 214 that rotationally drives the cam portion 217.
The pressing pin 218 is made of a metal or a hard synthetic resin, and is a pressing pin guide member (not shown) so as to be able to linearly protrude from the rotation center O of the cam portion 217 and return to the original rotation center O side. )). Further, the pressing pin 218 is pushed out and protrudes outward in the radial direction by the cam portion 217, and presses the arcuate tube portion 211a against the outer wall of the tube storage portion 224.
The cam portion 217 includes a first cam 215 and a second cam 216, and the first cam 215 and the second cam 216 can rotate in one direction (clockwise in FIG. 12) about the rotation center O. .
The first cam 215 and the second cam 216 are made of engineer plastic having high mechanical strength, such as polyacetal resin, or a metal having excellent strength and wear resistance. In particular, when a synthetic resin is used, it is preferable to mix the aforementioned filler. As described above, the synthetic resin mixed with this filler has high hardness and increased strength, exhibits a low coefficient of friction, and is difficult to wear. Since the first cam 215 and the second cam 216 come into contact with each other to push the pressing pin 218 in the radial direction and crush the arcuate tube portion 211a, the first cam 215 and the second cam 216 receive a large reaction force. Therefore, since the first cam 215 and the second cam 216 are required to have high hardness, high strength, and low friction coefficient, it is preferable to use a filler-containing synthetic resin.

Each of the first cam 215 and the second cam 216 includes two protrusions and a recess in plan view, and the two protrusions are formed at a planar position rotated by about 180 degrees. A gentle slope is formed over the recess.
As for the positions of the first cam 215 and the second cam 216 in plan view, in FIG. 12, four projecting portions are set at equal intervals on the entire circumference. This is because the first cam 215 and the second cam 216 are driven when the micropump 212 is driven, that is, when the micropump 212 is in a normal use state after the chemical solution supply device 201 is implanted under the skin of a laboratory animal. It is a plan view position, and each protrusion is set at a position rotated by approximately 90 degrees.

  In FIG. 12, the two pressing pins 218 by the protruding portion of the first cam 215 are pushed outward, and the wide portion at the tip of the pressing pin 218 presses the arcuate tube portion 211a. The center side end surface of the pressing pin 218 (one) arranged on the right side of the two pressing pins 218 is in contact with the slope portion of the first cam 215. Three of the pressing pins 218 arranged on the left side of the two pressing pins 218 are in contact with the recesses of the first cam 215, and one of the leftmost pressing pins 218 is the second cam. In contact with the slope portion 216, the arcuate tube portion 211a is hardly pressed together with the three adjacent left sides. Each pressing pin 218 is pushed back in the direction of the rotation center O by the elastic force of the arcuate tube portion 211a.

  When the chemical solution supply apparatus 201 is assembled, the micropump 212 is stopped, but the first cam 215 is rotated about 50 degrees clockwise (rightward) from the position of the first cam 215 in FIG. Assembled. The second cam 216 is assembled at a position slightly rotated counterclockwise (leftward) from the position of the second cam 216 in FIG. Accordingly, the two protrusions of each of the cams 215 and 216 are set at positions closer to each other than the position of FIG. 12, and the respective concave portions of the cams 215 and 216 are set at positions facing the pressing pin 218. Therefore, each cam portion does not press any of the pressing pins 218. Since the chemical solution supply apparatus 201 is shipped in this state, all of the pressing pins 218 are pushed onto the arcuate tube portion 211a until the chemical solution supply apparatus 201 is embedded in the experimental animal and the micropump 212 is rotationally driven. The pressure is not applied, and the arcuate tube portion 211a is prevented from being sag or deformed by continuing to be pressed, and the elastic force can be secured over a long period of time.

  After that, when the chemical solution supply device 201 is embedded in the experimental animal and the micropump 212 starts to rotate, each of the rotation driving units 214 engaged with the first cam 215 and the second cam 216 will be described later. The rotation drive shaft rotates, and the first cam 215 and the second cam 216 are driven to rotate. Here, when the first cam 215 rotates and abuts against the pressing pin 218 at the left end in FIG. 12, the first cam 215 slips with its rotation drive shaft until the protrusion of the second cam 216 rotates. Will stay in position. Next, the second cam 216 rotates, and the projection comes into contact with the left end of the first cam 215. The first cam 215 is pushed by the second cam 216 by the contact, and both of them are clockwise. Will rotate. In this case, the positions of the cams 215 and 216 in the rotational direction are as shown in FIG. 12, and the protruding portions of the first cam 215 and the second cam 216 are set at equal intervals of approximately 90 degrees. Is done. Thereafter, it is rotationally driven in the plane positional relationship, and as described above, each projection and slope push the pressing pin 218 outward in the radial direction. The tube portion 211a is pressed outward, and the chemical solution in the tube 211 is discharged to the outside (rightward in plan view of FIG. 12).

The height positions of the first cam 215 and the second cam 216 in a sectional view are configured to be substantially the same height as the pressing pin 218 as shown in FIG. In this case, while the first cam 215 and the second cam 216 make one rotation, each of the concave portions described above does not press the pressing pin 218 while rotating the position facing the pressing pin 218. Further, sag and deformation caused by continuously applying a pressing force to the arcuate tube portion 211a are prevented, and an elastic force can be secured over a long period of time.
Note that the elastic force that the pressing pin 218 pushes back toward the rotation center O does not use the elastic force of the arcuate tube portion 211a, but may apply the elastic force using a spring member. For example, a coil spring or a leaf spring may be installed between the pressing pin 218 and a pressing pin guide member (not shown).

The members for rotationally driving the first cam 215 and the second cam 216 are the respective rotational drive shafts protruding from the rotational drive unit 214. The rotational drive shafts are engaged and attached to the center holes of the first cam 215 and the second cam 216, respectively.
Each of the rotation drive shafts rotates about the same rotation center O, and one rotation drive shaft is inserted outside the other rotation drive shaft.
As shown in FIG. 15, each rotation drive shaft protrudes upward from the rotation drive unit 214 toward the first cam 215 and the second cam 216, and each rotation drive shaft has a gear train of various gears and pinions. It is rotated by the train wheel. The rotational drive source of the train wheel is a stepping motor, and a rotor having a two-pole permanent magnet attached to a rotating shaft rotates at an angle of 180 degrees within one opening of the stator. This rotary drive unit 214 almost adopts the structure of a step motor of a wristwatch, a train wheel, a second axle at the end of the train wheel, a cylindrical hook frictionally engaged with the second axle, and an hour wheel rotating in conjunction with the cylindrical hook. Is something that can be done. The step motor is driven with a DC voltage of about 1.5V.

13, 14, and 15, IC 225 is a circuit board, 226 is a circuit board on which an IC is mounted, and a wiring pattern for electrical connection with each electronic component or electronic element is formed on the surface. This circuit board 226 is screwed and attached to the lower base frame 205 with a circuit board fixing screw 227 as shown in FIG.
In FIG. 15, two external signal input ports 228 are formed on the lower surface of the lower lid 203.
The external signal input port 228 is preferably disposed in a plan view where there is some space in the cross-sectional view direction with the inner surface of the lower lid 203 and overlaps the circuit board 226 in a plan view. It can be anywhere. A more preferable arrangement location is the arrangement area of the liquid injection port 208 and the rotation driving unit 214 and its peripheral area in plan view. On the other hand, an unfavorable arrangement location is a plan view region of the reservoir 209 and the battery 210 and its peripheral region, and the reservoir 209 and the battery 210 are configured to the vicinity of the lower surface of the lower lid 203 in a sectional view.

The external signal input port 228 is formed inside a recess provided in the lower lid 203, and an input pin 229 made of a conductive material is fixed to the lower lid 203. When an external input terminal is pressed against the input pin 229, the vicinity of the recessed portion of the lower lid that fixes the input pin 229 is elastically deformed, so that the input pin 229 is formed on the lower surface of the circuit board 226. It will be in contact with the wiring pattern. Therefore, program data and control signals are input from the external input terminal to the IC via the input pin 229 and the wiring pattern of the circuit board 226.
With this input pin 229, the driving characteristics and driving program of the micropump 212 are input in advance to an IC. For example, the start time of the discharge of the chemical liquid, the end of the discharge, the discharge speed, the discharge amount per unit time, and the like. Although it is preferable to input before starting the animal experiment, it is possible to change the driving characteristics during the animal experiment. In order to input the change, it is necessary to project a connection cable connected to the input pin 229 outside the experimental animal.

Next, the sterilization process during assembly will be described.
First, a sterilization process is performed on the members constituting the passage of the chemical solution.
Here, the chemical solution passage path constituting member may indicate a liquid injection unit in which they are assembled, or may indicate an individual member. From the viewpoint of workability, it is preferable to sterilize after assembling the liquid injection unit.
First, the case where a sterilization process is performed after the liquid injection unit is assembled will be described.
The liquid injection unit is a unit in which the liquid injection port frame 220 of the liquid injection port 208, the liquid injection port packing 221, the reservoir 209, the connection pipe 222, and the tube 211 are assembled. This liquid injection unit is subjected to gas sterilization treatment with ethylene oxide gas, and sterilized.

  In this gas sterilization treatment with ethylene oxide gas, an ethylene oxide gas injection tool (or ethylene oxide gas supply device) is inserted from a liquid injection port packing 221 which is an inlet of the liquid injection unit, and the liquid injection part An ethylene oxide gas injection device (or ethylene oxide gas supply device) is inserted (connected) into the tip of the exposed tube portion 211b of the tube 211 that is the outlet of the unit, and the ethylene oxide gas injection inserted into the injection port packing 221 The ethylene oxide gas is injected from both ends of the injection port packing 221 side and the distal end side of the exposed tube portion 211b by both the tool and the ethylene oxide gas injection device connected to the distal end of the exposed tube portion 211b. In the chemical solution passage in the head unit. Side gas is filled. In this way, the inside of the liquid injection unit is sterilized. Ethylene oxide gas is discharged from the liquid injection unit after a predetermined time after the filling or a predetermined time after the ethylene oxide gas is injected. This discharge may be performed from either the liquid injection port packing 221 side or the distal end side of the exposed tube portion 211b, or from both. The gas may be discharged by a suction pump or natural discharge.

After confirming the discharge of the gas, the tip of the exposed tube portion 211b is heat-pressed and sealed.
By the above, the sterilization process of the chemical solution passage path of the liquid injection unit is completed. The thermocompression-bonded tip of the exposed tube portion 211b is opened at an appropriate timing before and after being embedded in a laboratory animal and connected to a catheter.
The injection and discharge of the ethylene oxide gas is not limited to the above procedure. For example, the ethylene oxide gas injection tool is inserted from the injection port packing 221 to inject the ethylene oxide gas, and the exposed tube portion 211b. As described above, the tip of the exposed tube portion 211b may be sealed by thermocompression bonding after confirming the discharge.

Next, the sterilization process is performed on the entire chemical solution supply apparatus 201. The sterilization process will be described. The liquid injection unit and the built-in member are assembled to the upper lid 202, the upper base frame 204, and the lower base frame 205 by tightening all of the exterior case fixing screws 213, thereby sealing the inside and completing the chemical solution supply apparatus 201. The entire chemical solution supply apparatus 201 in this state is subjected to gas sterilization treatment with ethylene oxide gas. The built-in member is, for example, a battery 210, an IC 225, a circuit board 226, a micro pump 212 (rotation drive unit 214, pressing pin 218, etc.), and the like.
As described above, the sterilization process is performed twice. That is, the gas sterilization process is performed after the liquid injection unit is assembled, and the gas sterilization process is performed after the chemical solution supply apparatus 201 is completed. The first sterilization process consists of a narrow passage and a small bag for the chemical solution passage. Therefore, the most suitable sterilization process (type of gas, gas pressure, gas injection time, etc.) You can choose. On the other hand, by performing sterilization after completion of the chemical solution supply apparatus 201, sterilization can be performed in a gas environment that does not damage the materials of the exterior case member and the built-in member.

The initial sterilization process in the liquid injection unit may be other than the gas sterilization process described above, and may be, for example, a high-pressure steam sterilization process or a radiation sterilization process.
In this high-pressure steam sterilization process, high-pressure steam of about 130 ° C. is passed through the chemical liquid passage of the liquid injection unit.
That is, as described above, a high-pressure steam injector (or high-pressure steam supply device) is inserted from the injection port packing 221 that is the inlet of the injection unit, and the tube 211 that is the outlet of the injection unit. A high-pressure steam injector (or high-pressure steam supply device) is inserted (connected) to the tip of the exposed tube portion 211b, and high-pressure steam is injected from both the injection port packing 221 side and both ends of the tip side of the exposed tube portion 211b. Similarly to the above-described discharge of ethylene oxide gas, high-pressure steam is discharged from the liquid injection unit. For this discharge, various methods are used similarly to the discharge of the ethylene oxide gas.

After confirming the discharge of the high-pressure steam, the tip of the exposed tube portion 211b is heat-pressed and sealed.
By the above, the sterilization process of the chemical solution passage path of the liquid injection unit is completed. Then, the thermocompression-bonded tip of the exposed tube portion 211b is opened at an appropriate timing before and after being embedded in the experimental animal and connected to the catheter.
The injection and discharge of the high-pressure steam is not limited to the above procedure. For example, the high-pressure steam is injected from the injection port packing 221 to inject the high-pressure steam, and the exposed tube portion 211b. As described above, the tip of the exposed tube portion 211b may be sealed by thermocompression bonding after confirming the discharge.
The steam temperature is not limited to the above-mentioned 130 ° C., and is preferably 120 ° C. to 150 ° C.

When the high-pressure steam sterilization treatment is performed on the liquid injection port frame 220 and the liquid injection port packing 221, the reservoir 209, the tube 211, the connection pipe 222, etc. of the liquid injection unit, the chemical solution passage path is constituted by a narrow passage and a small bag. Therefore, even if it is difficult to fill and remove the ethylene oxide gas, it is easy to pass high-temperature and high-pressure steam. The reason why the high-pressure steam sterilization treatment is not applied to the other built-in members, lid members, and base frame members is that the built-in members, lid members, and base frame members use plastic materials, and the plastic materials can withstand high temperature and pressure. This is because, similarly, a built-in member such as a functional component battery or an electronic component such as an IC is not damaged by applying high temperature and pressure.
The second sterilization process after the high-pressure steam sterilization process is performed on the entire chemical supply apparatus 201 is the same gas sterilization process as described above.
In addition, the first sterilization treatment is performed on each member before the liquid injection unit unit assembly in a sterile room or the like under aseptic conditions without human intervention, and then the liquid injection under aseptic conditions. The unit may be assembled.

In the above assembly, it is preferable to perform waterproofing so that the body fluid of the experimental animal does not enter the inside of the drug solution supply apparatus 201.
For this reason, the members having portions exposed to the outside are bonded to each other with an adhesive having a waterproof function attached thereto.
Contact surface on the outer peripheral side of the upper lid 202 and the upper base frame 204, contact surface on the outer peripheral side of the upper base frame 204 and the lower base frame 205, contact surface of the lower base frame 205 and the lower cover 203, liquid injection The inner wall surface of the injection opening 208b of the port 208, the upper outer peripheral wall surface of the injection port frame 220, the inner wall surface of the injection port frame 220 and the outer peripheral wall surface of the injection port packing 221 and the outer peripheral surface of the exposed tube portion 211b at the right end of the tube 211. On the inner peripheral wall surface of the tube exposure opening 223 provided on the right side walls of the upper lid 202 and the upper base frame 204, for example, an ultraviolet curable adhesive as the adhesive is applied, and the outer case fixing screw 213 is screwed. Immediately after that, when the entire surface of the chemical solution supply apparatus 201 is irradiated with ultraviolet rays, the aforementioned ultraviolet curable adhesive is cured, and waterproofness is ensured.

  Further, when a silicon coat (thin film) is formed on the externally exposed surface of the exterior case member (in the above case, the upper lid 202, the lower lid 203, the upper base frame 204, and the lower base frame 205) of the chemical solution supply apparatus 201, the waterproofing is achieved. Improves. The silicon coat may be formed on the externally exposed surface of the finished product assembled with the chemical solution supply device, or it may be an exterior case member (in the above case, the upper lid 202, the lower lid 203, the upper base frame 204, and the lower base frame 204). It may be applied to each part of the base frame 205) and then assembled to the chemical supply apparatus.

Next, the usage method of this chemical | medical solution supply apparatus 201 is demonstrated.
After the assembly of the apparatus 201, the drive control program for the rotation drive unit 214 of the micropump 212 (drive timings of the first cam 215 and the second cam 216, and the like) For controlling the driving speed of the cam, the driving method corresponding to those driving forces, and the driving conditions). Specifically, a program corresponding to a drive signal such as a drive start time, a drive pulse width, a drive pulse output cycle, and a drive voltage is given to a drive driver of a stepping motor (not shown) incorporated in the rotation drive unit 214. is there.
The drive control program described above may be stored in advance in the IC.
Further, a liquid injection tool is inserted into the liquid injection port packing 221 of the liquid injection port 208 to initially supply the chemical liquid into the reservoir 209.

After that, it is implanted under the skin of a laboratory animal.
Cut the skin of the experimental animal that had been paralyzed in advance, set the lower lid 203 of this drug solution supply device 201 under the skin, and sew the thread passed through the hole 207a of the thread hook 207 to the experimental animal. The chemical solution supply apparatus 201 is attached. Since the hole 207a of the thread hook portion 207 is provided in a plurality of locations around the periphery, the medicinal solution supply apparatus 201 can be stably attached.
Next, the chemical solution is set so that the chemical solution can be supplied to the body of the experimental animal, for example, the blood vessel via the catheter attached to the tip of the tube 211 protruding from the side wall of the chemical solution supply apparatus 201.
When the above preparation is completed, the animal experiment starts by sewing the skin of the experimental animal. The amount of chemical solution supplied by the micropump 212 (discharge amount to the experimental animal) is about 0.1 to 15 microliters per hour, but can be arbitrarily set in advance. It is also possible to program the IC in advance so as to change the discharge amount according to the elapsed time during the animal experiment.

  When several days have passed since the experimental animal moved around, the amount of drug solution stored in the reservoir 209 decreases. When this decrease is recognized by the elapse of a preset number of days or by detecting the remaining amount of the chemical in the reservoir 209 by the detection means, the experimenter can inject the liquid injector into the liquid injection port packing of the liquid injection port 208. 221 is inserted, and a chemical solution is additionally supplied into the reservoir 209. At this time, since the experimenter can easily visually recognize the portion where the surface of the experimental animal is partially raised by the injection port 208, the injecting device is inserted into the center of the rising portion and the inside of the reservoir 209 is inserted. Can be replenished with chemicals.

[Fourth Embodiment]
Next, 4th Embodiment is described based on FIG. 17, FIG.
In the third embodiment, the reservoir 209 and the battery 210 partially overlap each other in plan view. However, in the fourth embodiment, the reservoir 209 and the battery 210 are arranged so as not to overlap each other in plan view.
In the third embodiment, the arcuate tube portion 211a, the cam portion 217. The pressing pin 218 and the like are disposed above the rotation driving unit 214, but the fourth embodiment is different in that it is disposed below the rotation driving unit 214.
The rest is the same as in the third embodiment.

FIG. 17 is a plan view of the main part of the fourth embodiment, and FIG. 18 is a cross-sectional view of the main part at the CC position in FIG.
As shown in FIG. 17, the battery 210 is located slightly to the left of the center in the longitudinal direction (the left-right direction in FIG. 17) of the chemical solution supply device 201 and substantially in the center in the narrow width direction (the up-down direction in FIG. 17). Is arranged. As shown in FIG. 18, the battery 210 is a battery that is thick enough to substantially contact the inner surface of the upper lid 202 and the inner surface of the lower lid 203, for example, a button-type battery.
The reservoir 209 is formed in a semicircular shape on the battery 210 side so as to avoid the battery 210 as shown in FIG. 17, and as seen in FIG. 18, the reservoir 209 is almost in contact with the inner surface of the upper lid 202 and the inner surface of the lower lid 203. It is formed in the thickness.

As described above, since the battery 210 can be a thick battery in the height direction, it is possible to secure a large capacity, and since the battery capacity is also increased, the duration of the battery can be increased. Can continue.
In addition, since the reservoir 209 does not partially overlap with the battery in plan view as in the third embodiment, it is possible to ensure a large storage volume for the chemical solution.
Therefore, since the efficiency of securing the volumes of the reservoir 209 and the battery 210 is increased, the chemical solution supply apparatus 201 can be downsized in plan view. Therefore, when the chemical solution supply apparatus 201 is embedded in the experimental animal, the burden on the experimental animal can be reduced, which contributes to increasing the certainty of the animal experiment of the chemical solution.
Moreover, it is not necessary to provide the reservoir 209 with a stepped portion for avoiding the battery 210 as seen in FIGS. That is, the reservoir 209 can be formed with the same thickness over almost the entire region of the chemical solution storage portion so that it can be formed from the inner surface of the upper lid 202 to the inner surface of the lower lid 203, for example. Even if contraction and expansion are repeated, there is no portion where the strength is lost, and a stable long-term strength can be ensured.

Furthermore, since the battery 210 is formed thick as described above in a sectional view, the main part of the liquid injection port 208 is disposed so as not to overlap the battery 210 in a plan view. That is, the liquid injection port frame 220 and the liquid injection port packing 221 shown in FIG. 17 do not overlap with the battery 210 in plan view.
The connection cylinder part 220b of the liquid injection port frame 220 connected to the reservoir 209 from the liquid injection port 208 is disposed above the battery 210 in a plan view and does not overlap the battery 210 in a plan view.
Similarly, the connection pipe 222 connected from the reservoir 209 to the micropump 212 is installed below the battery 210 as shown in FIG. 17 so as to avoid the battery 210 in plan view.

Further, as shown in FIG. 18, the cross-sectional view is as follows.
The connecting cylinder portion 220b connected to the reservoir 209 from the liquid injection port 208 is connected to the upper side from the central portion of the reservoir 209 in a cross-sectional view as shown in FIG. 14 as in the third embodiment.
The connection pipe 222 connected from the reservoir 209 to the tube 211 is disposed below the reservoir 209 as shown in FIG. 18, and is connected to the lower side of the central portion of the reservoir 209 in a sectional view. Yes.
Further, in the micropump 212, the connection pipe mounting portion 211c of the tube 211 communicating with the connection pipe 222, the first cam 215 and the second cam 216 constituting the cam portion 217, the pressing pin 218, the arcuate tube portion 211a. 18 are installed at the inner surface side of the lower lid 203 in a sectional view as shown in FIG. The exposed tube portion 211b in the tube 211 is also located on the inner surface side of the lower lid 203 and protrudes to the outside.
Therefore, the micropump 212 is disposed in the direction opposite to the third embodiment in the cross-sectional view direction. That is, the rotation drive part 214, the connection pipe attachment part 211c of the tube 211, the first cam 215 and the second cam 216 constituting the cam part 217, the pressing pin 218, the arcuate tube part 211a, etc. are shown in FIGS. Is configured in the opposite direction in the cross-sectional view direction.
Similarly, the circuit board 226 and the IC 225 are provided above the rotation driving unit 214 in a sectional view.

Therefore, in the flow of the chemical solution, a smooth flow that is not unreasonable is easily performed in a plan view and a cross-sectional view.
That is, in plan view, as shown in FIG. 17, the chemical solution storage portion 209 c for the reservoir 209 is formed in the central region of the reservoir 209, and the liquid injection port 208, which can be referred to as a chemical solution supply inlet, A connection pipe 222 that can be said to be a chemical solution discharge port is formed below the chemical solution storage unit 209c.
Accordingly, when the chemical solution is injected from the liquid injection port 208 on the upper side of the chemical solution storage unit 209c, the chemical solution is smoothly stored in the chemical solution storage unit 209c, and is smoothly discharged from the connection pipe 222 on the lower side of the chemical solution storage unit 209c. As a result, the chemical liquid does not stay and the chemical liquid flows through the flow path without difficulty.

On the other hand, in a cross-sectional view, as shown in FIG. 18, in the chemical solution storage unit 209c of the reservoir 209, when the chemical solution is injected from the liquid injection port 208 on the upper side, the chemical solution storage unit 209c smoothly stores the chemical solution. It is smoothly discharged from the connecting pipe 222 below the portion 209c.
Moreover, also in the micropump 212, as described above, the connection pipe mounting portion 211c, the cam portion 217, the pressing pin 218, the arcuate tube portion 211a, and the exposed tube portion 211b of the tube 211 communicating with the connection pipe 222 are also included. It is located on the inner surface side of the lower lid 203 so as to be almost the same height as the connection pipe 222 and projects to the outside.
Therefore, there is no stagnation of the chemical liquid, and the chemical liquid flows through the flow path without difficulty and is discharged to the outside.
In particular, when the chemical solution supply apparatus 201 is embedded in an experimental animal, if the chemical solution supply apparatus 201 is embedded so that the lower lid 203 is on the lower side in the vertical direction and the upper lid 202 is on the upper side in the vertical direction, the chemical solution is aligned with gravity. Since the flow path is formed so as not to be unreasonable, it becomes easier to flow more smoothly.

On the other hand, as shown in FIG. 17, the battery 210 is disposed in the center of the narrow width direction and the longitudinal direction of the chemical solution supply apparatus 201. In addition, the reservoir 209 and the micropump 212 are also arranged substantially at the center in the narrow width direction.
The battery 210, the reservoir 209 in which the chemical solution is stored, the micropump 212, and especially the rotation drive unit 214 are relatively heavy units, and the unit having a large weight is almost in the narrow width direction and the longitudinal direction. By being arranged in the center, the stability of fixation when the chemical solution supply apparatus 201 is implanted in a laboratory animal and an animal experiment is performed is enhanced. In other words, since the center of gravity of the chemical solution supply apparatus 201 is located at substantially the center in the plan view of the chemical solution supply apparatus 201, the chemical solution supply apparatus 201 has an unreasonable effect on the experimental animal implantation portion when the experimental animal moves. It is because it receives less power. Therefore, the experiment is stably continued.

[Fifth Embodiment]
The fifth embodiment is different from the third embodiment in that, as shown in the plan view of FIG. 19, the liquid injection port 208 is arranged on the center side in the narrow width direction in the plan view of the chemical liquid supply device 201. It is that.
In FIG. 19, the liquid injection port 208 is disposed substantially at the center in the narrow width direction of the chemical liquid supply device 201. The point 201a, that is, the distance from the upper edge and the distance from the lower edge in FIG. However, the substantially equal position includes being within a predetermined range width 201b from the intermediate point 201a. The predetermined range width 201b is set to 1/5 of the maximum width 201c of the chemical solution supply apparatus 201. The predetermined range width 201b is more preferably a tenth of the maximum width 201c, and even more preferably a fifteenth.

  As described above, since the center position 208d of the liquid injection port 208 exists in the vicinity of the intermediate point 201a in the narrow width direction of the chemical liquid supply device 201, the liquid injection tool is inserted into the liquid injection port 208 and the inside of the reservoir 209 is inserted. When the chemical solution is replenished, the puncturing force of the liquid injector is not applied to the experimental animal in the direction in which the chemical solution supply device 201 is inclined. That is, if the center position 208d of the liquid injection port 208 is formed not in the vicinity of the intermediate point 201a in the narrow width direction of the chemical liquid supply device 201 but in a biased position near the upper edge or the lower edge, Since the piercing force into the liquid injection port 208 by the liquid injection tool works at a location close to the upper edge or the lower edge, the chemical solution supply device 201 easily tilts toward the upper edge side or the lower edge side, and the liquid injection device 208 is injected into the liquid injection port 208. It becomes difficult to replenish the medicinal solution by the liquid tool, and also causes local pain by tilting the replenishment experimental animal, so that the liquid injection operation is likely to be hindered. On the other hand, in the present embodiment, when a liquid injector is inserted into the liquid injection port 208 and the chemical liquid is replenished into the reservoir 209, the chemical liquid supply device 201 has a substantially uniform insertion force in the narrow width direction. Therefore, the chemical solution replenishing operation is performed smoothly without giving local pain to the experimental animal.

In the plan view of FIG. 19, the reservoir 209 and the battery 210 overlap in a plan view, but this is different from the third embodiment.
The liquid injection port 208 is disposed between the reservoir 209 and the micropump 212, and is disposed between the battery 210 and the micropump 212.
As described above, since the liquid injection port 208 is disposed between the reservoir 209 or the battery 210 and the micropump 212 in a plan view, the chemical liquid supply apparatus is also used in the longitudinal direction of the chemical liquid supply apparatus 201 (the left-right direction in FIG. 19). The liquid injection port 208 is disposed near the center of 201. Therefore, in the same manner as described above, when a liquid injector is inserted into the liquid injection port 208 and the chemical liquid is replenished into the reservoir 209, the chemical liquid supply apparatus 201 is inserted almost evenly over the entire area of the chemical liquid supply apparatus 201 in the longitudinal direction. Since the force is applied, the chemical solution replenishing operation is smoothly performed without giving local pain to the experimental animal.
Note that when the liquid injection port 208 is disposed in the substantially central portion in the narrow width direction and the longitudinal direction, the pulling force over the entire region of the chemical liquid supply apparatus 201 is also obtained when the liquid injection tool is pulled out from the liquid injection port 208. Therefore, the injection operation can be performed generally well without giving local pain to the experimental animal.

[Sixth Embodiment]
Next, a sixth embodiment will be described with reference to FIGS.
In the sixth embodiment, the outer shape of the chemical solution supply apparatus is particularly modified.
FIG. 20 shows an external view of a chemical solution supply apparatus for implantation under the skin of a laboratory animal. 20A is a side view seen from the bottom of the chemical liquid supply device, and is a side view seen from the front side of the paper in FIG. 22, and FIG. 20B is an upper view seen from above the chemical liquid supply device. 22 is a side view as viewed from the upper side of the paper in FIG. 22, FIG. 20C is a right side view as viewed from the right side of the medicinal solution supply apparatus, and FIG. 20D is a medicinal solution supply apparatus. It is the left view side view seen from the left. FIG. 21 is an enlarged view of the right side in FIG. 20A of the chemical liquid supply apparatus of the present invention, and is also a side view of a thread hook portion that is sewn to the experimental animal with a thread when the chemical liquid supply apparatus is embedded in the experimental animal. . FIG. 22 is a plan view of the present chemical solution supply device, and is a plan view as viewed from the upper side of the sheet of FIG. 23 is a cross-sectional view of the main part at the position A2-A2 in FIG. 24 is a cross-sectional view of the main part at the position B1-B1 in FIG. FIG. 25 is a cross-sectional view of the main part of the micropump portion of FIG. FIG. 26 is an enlarged cross-sectional view of the liquid injection port.

First, the appearance of the chemical solution supply device (fluid transport device) 301 will be described.
In FIG. 20, the chemical solution supply device 301 for implantation under the skin of a laboratory animal has a substantially box shape in appearance. The width dimension in the wide direction (longitudinal direction) is approximately 34 mm, the depth dimension in the narrow direction (short direction) is approximately 18 mm, and the height dimension is approximately 8.5 mm.
As the exterior case, an upper lid 302, a lower lid 303, an upper base frame 304, and a lower base frame 305 are fixed to each other. The material of the member that contacts the experimental animal such as the upper lid 302, the lower lid 303, the upper base frame 304, the lower base frame 305, etc. needs to be non-toxic to the experimental animal. In addition, since the member is also a functional member, high strength and high hardness are required. Therefore, the materials of the upper lid 302, the lower lid 303, the upper base frame 304, the lower base frame 305 and the like as the outer case are non-toxic to the experimental animal, have high strength and high hardness, and are preferably lightweight. Synthetic resins such as polypropylene, polystyrene, and polycarbonate are used. After assembling, it is preferable to ensure non-toxicity by performing a silicon coating treatment. In addition, you may make it select the above-mentioned material from a viewpoint of ensuring biocompatibility.
The upper lid 302 is made of a transparent material, and can easily identify whether the built-in structure or the assembled state and the operating state of the parts are normal or abnormal. The lower lid 303, the upper base frame 304, and the lower base frame 305 as other exterior case members are made of a non-transparent colored resin.

  The upper lid 302, the lower lid 303, the upper base frame 304, and the lower base frame 305 have a function of storing and holding a built-in member. For example, when the chemical solution is replenished and released, it expands and contracts. This is a member for holding the reservoir 309. Since the reservoir 309 expands and contracts as described above, for example, the reservoir 309 slides somewhat between the upper lid 302, the lower lid 303, the upper base frame 304, and the lower base frame 305. As will be described later, the arcuate tube portion 311a of the tube 311 is sequentially pressed by a plurality of pressing pins 318. Therefore, the upper lid 302 holding the pressed arcuate tube portion 311a on the side wall and The pressing force acts on the upper base frame 304, and the arcuate tube portion 311a slides somewhat between its side walls as the arcuate tube portion 311a expands and contracts.

  Accordingly, members having a function of storing and holding the built-in member, for example, the upper lid 302, the lower lid 303, the upper base frame 304, and the lower base frame 305 are required to have high strength and low friction coefficient. Yes. Therefore, for example, a member having a function of storing and holding the built-in member such as the upper lid 302, the lower lid 303, the upper base frame 304, the lower base frame 305, and the like is filled with a filler that contributes to low friction. You may make it do.

  As will be described later, in FIG. 25, an arcuate tube portion support wall 324a constituting a tube storage portion 324 for storing the arcuate tube portion 311a of the micropump 312 is formed by an upper lid 302 and an upper base frame 304. Since the pressing pin 318 sequentially presses the arcuate tube portion 311a, the arcuate tube portion support wall 324a receives the arcuate tube portion support wall 324a. Therefore, the upper lid 302 and the upper base frame 304 constituting the arcuate tube portion support wall 324a may be filled with a filler that contributes to high strength and low friction. Therefore, even when the arcuate tube portion 311a is pressed by the pressing pin 318, the arcuate tube portion support wall 324a is not deformed, and a stable liquid pump for supplying a chemical solution that does not change with time can be provided.

Now, the external shape of the chemical solution supply apparatus 301 is as follows.
As shown in FIG. 20A, the upper surface of the chemical solution supply device 301 is formed in a convex shape so that the central portion is highest in the wide direction (longitudinal direction). Accordingly, the upper surface shape of the upper lid 302 is formed in an arc shape having a radius R1 as shown in FIG. On the other hand, the lower and rear surfaces of the chemical liquid supply device 301 are formed in a concave shape so that the central portion is highest (depressed) in the wide direction (longitudinal direction). Therefore, the lower surface shape of the lower lid 303 is formed in an arc shape having a radius R2 as shown in FIG. The sizes of the radii R <b> 1 and R <b> 2 may be set along the subcutaneous shape of the animal in which the drug solution supply device 301 is embedded. R1 and R2 may be concentric or non-concentric.

FIG. 21 is an enlarged view of the right side portion in FIG. The substantially central portion of the upper surface in the longitudinal direction is higher by a height h31 from the boundary position between the later described long right inclined surface 301e (or long left inclined surface 301d) and the above upper surface due to the convex shape described above. This boundary position is an intersection position between the long right inclined surface 301e and the convex extension line of the upper surface.
The substantially central portion of the lower back surface in the longitudinal direction is raised by a depth h41 from the lower surface positions at both ends of the lower back surface due to the concave shape described above.

Further, in the narrow direction (short direction) in the longitudinal direction and the orthogonal direction, it is as follows.
As shown in FIG. 20C, the upper surface of the chemical solution supply device 301 is formed in a convex shape so that the central portion is the highest in the narrow direction. Therefore, the upper surface shape of the upper lid 302 is formed in an arc shape with a radius r1 as shown in FIG. On the other hand, the lower back surface of the chemical solution supply device 301 is formed in a concave shape so that the central portion is highest (depressed) in the narrow direction. Therefore, the lower surface shape of the lower lid 303 is formed in an arc shape with a radius r2 as shown in FIG.
The r1 and r2 may be concentric or non-concentric.
The upper surface shape in the longitudinal direction and the upper surface shape in the narrow direction need not be arc-shaped, for example, may be non-arc-curved or may be a combination of straight lines. The upper surface of 301 may be formed in any way as long as it is formed in a convex shape so that the vicinity of the center is highest in the longitudinal direction or the narrow direction.

Similarly, the lower back surface shape in the longitudinal direction and the lower back surface shape in the narrow direction do not have to be arc shapes, for example, may be non-arc curved shapes, or may be a combination of straight lines. The lower back surface shape of the device 301 may be formed in any way as long as it is formed in a concave shape so that the vicinity of the central portion is highest (depressed) in the longitudinal direction or the narrow direction.
The upper surface shape in the longitudinal direction is formed in the convex shape, but the upper surface shape in the narrow direction may be a linear shape, and conversely, the upper surface shape in the longitudinal direction is formed in a linear shape. However, the upper surface shape in the narrow direction may be the convex shape.
The lower back surface shape in the longitudinal direction is formed in the concave shape, but the lower back surface shape in the narrow direction may be a linear shape, and conversely, the lower back surface shape in the longitudinal direction is formed in a linear shape. However, the lower back surface shape in the narrow direction may be the concave shape.
The shape of the upper surface in the longitudinal direction, the sizes of the radii R1 and R2, the height h31, and the depth h41 can be set according to the skin shape and subcutaneous shape of the animal into which the drug solution supply device 301 is embedded. Good.
The shape of the upper surface in the narrow direction, the sizes of the radii r1 and r2, the height h31, and the depth h41 can be set according to the skin shape and subcutaneous shape of the animal in which the drug solution supply device 301 is embedded. Good.

  By forming the upper surface in a convex shape, or by forming the lower back surface in a concave shape, when the drug solution supply device 301 is implanted, the upper surface shape substantially along the subcutaneous shape of the animal, Moreover, since it is formed in the lower back surface shape, it becomes easy to adapt to the skin and the like, and it is possible to prevent or reduce the occurrence of excessive pulling and damage to the animal. In particular, the upper surface is formed in a convex shape and the lower back surface is formed in a concave shape at the same time, so that each upper surface or each lower back surface of the chemical liquid supply device 301 is in contact with the skin inner surface shape, subcutaneous shape, etc. of the animal. It becomes easy to follow, and the above-mentioned effect can be made more effective.

The exterior case is formed in a narrow-side outer wall formed in a narrow direction at one end in the wide direction (longitudinal direction) in the chemical solution supply device, and in a narrow direction at the other end in the wide direction. The narrow outer wall is formed on an inclined surface that is inclined so that the width in the wide direction becomes narrower from the lower back surface to the upper surface of the outer case.
That is, the left and right side surfaces in the longitudinal direction of the chemical solution supply device 301 are inclined surfaces such that the size in the longitudinal direction of the chemical solution supply device 301 becomes narrower as it goes upward, as shown in FIGS. In FIG. 2, a left left inclined surface 301d and a long right inclined surface 301e are formed. When the inclined surfaces 301d and 301e are implanted under the skin of the experimental animal, the skin of the experimental animal is pulled according to the volume and height of the chemical solution supply device 301. In the worst case, the skin is damaged. Become. In view of this, the inclined surfaces 301d and 301e are formed so that the pulling is as small as possible and a local shearing force is not applied to the skin.
The inclination angles α11 and α21 of the inclined surfaces 301d and 301e are angles formed by the inclined surfaces 301d and 301e with respect to a vertical line perpendicular to the flat surface when the chemical solution supply device 301 is placed on a flat surface. Are the inclination angles α11 and α21. The inclination angles α11 and α21 are preferably 5 to 60 degrees, more preferably 15 to 30 degrees. The inclination angles α11 and α21 of the inclined surfaces 301d and 301e may be the same or different.

Further, the outer case has a wide outer wall formed in the wide direction at one end in the narrow direction in the chemical solution supply apparatus, and a wide width formed in the wide direction at the other end in the narrow direction. The side outer wall is formed on an inclined surface that is inclined so that the width in the narrow direction becomes narrower from the lower back surface to the upper surface of the exterior case.
That is, the narrow side surface of the chemical solution supply device 301 illustrated in FIGS. 20C and 20D does not have to be provided with the inclined surface as described above (β is 0 degree), It is preferable to make the inclined surface narrow in width as it goes. In FIG. 20C, a width-left inclined surface 301f and a width-right inclined surface 301g in the narrow direction are formed. The inclination angles β11 and β21 of the inclined surfaces 301f and 301g are angles formed by the inclined surfaces 301f and 301g with respect to a vertical line perpendicular to the flat surface when the chemical solution supply device 301 is placed on a flat surface. Are the inclination angles β11 and β21. The inclination angles β11 and β21 of the inclined surfaces 301f and 301g are preferably 5 to 45 degrees, and more preferably 10 to 30 degrees. The inclination angles β11 and β21 of the inclined surfaces 301f and 301g may be the same or different.

The inclination angle is preferably larger from the viewpoint of reducing the pulling of the skin of the experimental animal. However, the internal space of the chemical solution supply device 301 and the efficient arrangement of the built-in members, and the chemical solution supply device 301 at the initial injection of the chemical solution From the viewpoint of being easily held and held by hand, a smaller one is preferable, and both viewpoints may be determined by comprehensive judgment.
The inclined surfaces 301d, 301e, 301f, and 301g are not limited to being formed in a straight line as described above, and may be curved. The curve is preferably a convex curve in which the central part of the inclined surface 301d, 301e, 301f, 301g is convex. The degree of the inclination is such that the tangent lines of the inclinations 301d, 301e, 301f, and 301g at the height position 1/2 of the height (thickness) H1 of the chemical solution supply apparatus 301 are the vertical lines (vertical direction lines in FIG. 20). ) Are α11, α21, β11, and β21 described above, and these angles α11, α21, β11, and β21 are preferably set to the aforementioned angles.
In this way, by forming the inclined surfaces 301d, 301e, 301f, and 301g into a convex non-linear shape, it is possible to further prevent unreasonable tension and damage that are more familiar to animals.

When viewed from the side (as viewed from the side), the upper, lower, left and right corners are formed in an arc shape so as not to damage the subcutaneous part of the experimental animal.
As shown in FIG. 20A, the left and right corners in the longitudinal direction of the lower lid 301 have a large arc shape, and the width of the lower lid 303 is shown in FIG. The left and right corners in the narrow direction are formed in a large arc shape. Similarly, as shown in FIG. 20A, the left and right corners in the longitudinal direction of the upper lid 302 are formed in a large arc shape, and as shown in FIG. 20C, the left and right corners in the narrow direction of the upper lid 302 are It is formed in a large arc shape. The arcuate portion in the longitudinal direction is formed in an arc shape with a larger radius than the arcuate portion in the narrow direction, and the arc shape portions of the lower lid 303 are each formed in an arc shape with a larger radius than the arc shape portion of the upper lid 302. Has been. Note that the size of the radius may be opposite to that described above, or may be an arc having substantially the same radius.

As shown in FIGS. 20 (C), (D) and FIG. 21, the chemical solution supply device 301 is threaded to thread the thread to sew and fix the experimental animal under the experimental animal's skin. A thread hook portion 307 as an attachment portion is formed to protrude at a plurality of locations. The thread hook portion 307 is provided with a hole 307a for passing a thread.
The thread hook 307 protrudes from the side surface of the lower lid 303, and is located at a predetermined height h11 from the bottom surface of the lower lid 303 to the lower surface of the thread hook 307. This predetermined height h11 is 1/10 to 1/2, preferably 1/5 to 1/3 of the thickness of the chemical solution supply device 301, that is, the thickness H1 from the upper surface of the upper lid 302 to the lower surface of the lower lid 303. It is preferable to be formed at the position. That is, since the thread hook 307 has the height h11, when the chemical supply device 301 is sewn to the experimental animal with a thread, the sewing portion of the experimental animal is attached to the thread hook 307. This is because the close-up position in plan view can be obtained, and the chemical solution supply device 301 can be drawn to the lower side, and can be attached so as not to float.

The yarn hooking portion 307 may be formed so as to protrude from the side surface of the lower base frame 305. In this case, the yarn hooking portion 307 may be at a position where the predetermined height h11 is secured, or may be formed so as to protrude in the plan view direction from the lower surface of the lower lid 303 which is the bottom surface of the chemical solution supply device 301.
Further, the position in plan view where the yarn hooking portion 307 is formed is the left and right side portions of the chemical solution supply apparatus 301 as shown in FIG. That is, on the right side, there are three diameters in the vicinity of the portion where the tube 306 protrudes to the outside, two locations on the upper side, and one location near the center of the left side surface.
The thread hooking portion 307 further moves the protruding portion of the tube 306 protruding from the side surface of the chemical liquid supply device 301 if the thread hooking portion 307 is positioned on both sides of the protruding position of the tube 306 at the right side formation portion. Therefore, the chemical solution can be stably supplied to the experimental animal without moving the catheter for supplying the chemical solution to the experimental animal.

The formation place of the thread hook portion 307 in a plan view is preferably inside the quadrilateral that is in contact with the maximum outer shape end of the outer case as shown in FIG. The quadrilateral in contact with the maximum outer edge of the outer case is designated as follows in FIG. That is, the longitudinal tangent e11 of the upper end constituting the maximum width of the exterior case in the longitudinal direction of the chemical solution supply device 301, and the longitudinal tangent e21 of the lower end constituting the maximum width of the exterior case in the longitudinal direction. The longitudinal direction is the narrow width direction tangent line e31 that forms the maximum width of the outer case in the narrow direction in the orthogonal direction, and the maximum width of the outer case in the narrow direction (short direction). A quadrilateral is drawn by the narrow direction tangent line e41 at the left end. Each of the thread hooks 307 is arranged in a quadrilateral surrounded by the e1, e2, e3, and e4 in a plan view.
As described above, the yarn hooking portions 307 are arranged in the quadrilateral in a plan view, so that the yarn hooking portions 307 do not jump out of the side surface of the exterior case. The hanging portion 307 prevents the experimental animal from being pressed unnecessarily, thereby damaging the experimental animal and causing discomfort. In particular, since each of the thread hooks 307 is likely to be formed in a protruding shape, it is likely to press the experimental animal locally, and it is easy to cause the damage. It is an effective means for preventing the problem.
Further, as shown in FIG. 20A, the tube 311b protrudes from the side.

  Next, a plan view of the chemical liquid supply apparatus 301 in a plan view (a state in which the chemical liquid supply apparatus 301 is viewed from above in FIG. 20A) is illustrated in FIG. As shown in the plan view, the same configuration as that of the third embodiment shown in FIG. 12 is adopted. The liquid injection port 308, the reservoir 309, the battery 310, the tube 311, the arc-shaped tube portion 311a, and the exposed tube shown in FIG. Part 311b, micropump 312, exterior case fixing screw 313, rotation drive part 314, first cam 315, second cam 316, cam part 317, pressing pin 318, guide support 319, integrated circuit (IC) 325, circuit board For 326, 208, reservoir 209, battery 210, tube 211, arcuate tube portion 211a, exposed tube portion 211b, micropump 212, exterior case fixing screw 213, rotation drive portion 214, first cam shown in FIG. 12 respectively. 215, the second cam 216, the cam portion 217, the pressing pin 218, and the guide foot 219 Since the integrated circuit (IC) 225, is similar to the circuit board 226 is used, the description thereof is omitted.

Next, the schematic cross-sectional structure of the chemical solution supply apparatus 301, the detailed structure and materials of the main part are shown in FIGS. 21, 22, 23, 24, 25, and 26. These correspond to FIGS. 11, 12, 13, 14, 15, and 16 of the third embodiment.
Accordingly, the upper lid 302, the lower lid 303, the upper base frame 304, the lower base frame 305, and the exterior case fixing screw 313 described in FIGS. 203, the description of the upper base frame 204, the lower base frame 205, and the exterior case fixing screw 213 is omitted.
Further, as described above, the liquid injection port 308 is the same as the liquid injection port 208 of the third embodiment, and the liquid injection port protrusion 308a, the injection opening 308b, the inclined surface 308c, the liquid injection port frame 320, the space About the part 320a, the connecting cylinder part 320b, the communication path 320c, and the liquid injection port packing 321, the liquid injection port protrusion 208a, the injection opening 208b, the inclined surface 208c, and the liquid injection port frame 220 of the third embodiment shown in FIG. , The space 220a, the connecting cylinder 220b, the communication passage 220c, and the injection port packing 221 are the same as those described above, and the description thereof is omitted.
Further, regarding the dimensions of the liquid injection port protrusion 308a, the outer diameters d11 and h21, the inclination angle γ1, the inner diameter d21, the outer diameter d31, and the diameter d41 shown in FIG. 26 are the outer diameters d1 of the third embodiment shown in FIG. , H2, the inclination angle γ, the inner diameter d2, the outer diameter d3, and the diameter d4, the description is omitted.

As described above, the shape and material of the reservoir 309 are the same as those of the reservoir 209 of the third embodiment, and the liquid injection port connection portion 309a, the connection pipe connection portion 309b, and the chemical solution storage portion 309c are shown in FIG. Since it is the same as the description regarding the liquid injection port connection part 209a, the connection pipe connection part 209b, and the chemical | medical solution storage part 209c of 3rd Embodiment shown in FIG.
As described above, the shape and material of the tube 311 are the same as those of the tube 211 of the third embodiment, and the arcuate tube portion 311a, the exposed tube portion 311b, and the connection pipe attachment portion 311c are shown in FIGS. Since it is the same as the description regarding the circular arc-shaped tube part 211a, the exposed tube part 211b, and the connection pipe attachment part 211c of 3rd Embodiment shown in FIG. 16, description is abbreviate | omitted.
As described above, the shape and material of the micropump 312 are the same as those of the micropump 212 of the third embodiment, and the rotation drive unit 314, the first cam 315, the second cam 316, the cam unit 317, the press Regarding the pin 318, the tube exposure opening 323, the tube storage portion 324, the arcuate tube portion support wall 324a, and the rotation center O1, the rotation drive portion 214, the first cam 215, the first cam 215 of the third embodiment shown in FIGS. 2 The cam 216, the cam part 217, the pressing pin 218, the tube exposure opening 223, the tube storage part 224, the arcuate tube part support wall 224a, and the description about the rotation center O are omitted.
In addition, for the connection pipe 322, IC 325, circuit board 326, circuit board fixing screw 327, external signal input port 328, and input pin 329, the connection pipe 222, IC 225, and circuit board of the third embodiment shown in FIGS. 226, the circuit board fixing screw 227, the external signal input port 228, and the input pin 229, the description is omitted.

Moreover, about the chemical | medical solution supply apparatus 301 which concerns on this 6th Embodiment, the chemical | medical solution which concerns on 3rd Embodiment regarding the sterilization process of each component at the time of the assembly method and assembly, and also about the sterilization process with respect to the chemical | medical solution supply apparatus 301 whole Since it is the same as the description regarding the supply apparatus 201, description is abbreviate | omitted.
In addition, waterproof treatment is performed so that the body fluid of the experimental animal does not enter the inside of the medicinal solution supply apparatus 301, and members having parts exposed to the outside are bonded to each other with a waterproof function for this waterproof treatment. Since it is the same as the description regarding the chemical | medical solution supply apparatus 201 which concerns on 3rd Embodiment also about being adhered by the chemical | medical agent, it abbreviate | omits description.
Moreover, since the usage method of this chemical solution supply apparatus 301 is the same as the description regarding the chemical solution supply apparatus 201 according to the third embodiment, the description thereof is omitted.

[Seventh Embodiment]
Next, a seventh embodiment will be described with reference to FIGS.
In the sixth embodiment, the reservoir 309 and the battery 310 partially overlap in plan view, but in the seventh embodiment, the reservoir 309 and battery 310 are arranged so as not to overlap in plan view.
In the sixth embodiment, the arcuate tube portion 311a and the cam portion 317. The pressing pin 318 and the like are disposed above the rotation driving unit 314. However, the seventh embodiment is different in that it is disposed below the rotation driving unit 314.
The rest is the same as in the sixth embodiment.

27 is a plan view of the main part of the second embodiment, and FIG. 28 is a cross-sectional view of the main part at the position C1-C1 in FIG.
In FIG. 28, a substantially central portion in the longitudinal direction of the upper lid 302 is formed in a convex shape protruding slightly upward, and a lower back surface of the lower lid 303 is formed in a concave shape. The concave shape of the lower back surface is formed with a horizontal straight line at the substantially central side, a straight line with a lower left side on the left end side, and a straight line with a lower right side on the right end side.
As shown in FIG. 27, the battery 310 is located slightly to the left of the center in the longitudinal direction (left and right direction in FIG. 27) of the chemical solution supply device 301 and substantially in the center in the narrow direction (up and down direction in FIG. 27). Has been placed. As shown in FIG. 28, the battery 310 is a battery that is so thick as to be substantially in contact with the inner surface of the upper lid 302 and the inner surface of the lower lid 303, for example, a button-type battery.
The reservoir 309 is formed in a semicircular shape on the battery 310 side so as to avoid the battery 310 as shown in FIG. 27, and as shown in FIG. 28, the reservoir 309 is almost in contact with the inner surface of the upper lid 302 and the inner surface of the lower lid 303. It is formed in the thickness.

  In addition, the seventh embodiment is the same as the fourth embodiment shown in FIGS. 17 and 18, and the liquid injection port 308, the reservoir 309, the chemical solution storage unit 309c, the battery 310, the tube 311, and FIGS. Arc-shaped tube portion 311a, exposed tube portion 311b, connection pipe mounting portion 311c, micro pump 312, rotation drive portion 314, first cam 315, second cam 316, cam portion 317, pressing pin 318, liquid injection port frame 320, Regarding the connection cylinder part 320b, the injection port packing 321, the connection pipe 322, the circuit board 326, and the IC 325, the injection port 208, the reservoir 209, the chemical storage part 209c, and the battery 210 of the fourth embodiment shown in FIGS. , Tube 311, arcuate tube portion 311 a, exposed tube portion 311 b, connection pipe removal Part 311c, micropump 312, rotation drive part 314, first cam 315, second cam 316, cam part 317, pressing pin 318, liquid injection port frame 320, connection cylinder part 320b, liquid injection port packing 321, connection pipe 322 Since it is the same as the description about the circuit board 326 and the IC 325, the description is omitted.

[Eighth Embodiment]
The eighth embodiment is different from the sixth embodiment in that, as shown in the plan view of FIG. 29, the liquid injection port 308 is arranged on the center side in the narrow direction in the plan view of the chemical liquid supply device 301. It is that. Other configurations, in particular, the outer shape of the exterior case as the chemical solution supply apparatus are formed in the same manner as in the sixth embodiment.
Further, the seventh embodiment is the same as the fifth embodiment shown in FIG. 19, and the intermediate point 301a, the predetermined range width 301b, the maximum width 301c, the liquid injection port 308, the center position 308d, the reservoir 309, The battery 310 and the micropump 312 are related to the intermediate point 201a, the predetermined range width 201b, the maximum width 201c, the injection port 208, the center position 208d, the reservoir 209, the battery 210, and the micropump 212 of the fifth embodiment shown in FIG. Since it is the same as that of description, description is abbreviate | omitted.

[Ninth Embodiment]
Next, a ninth embodiment will be described with reference to FIG.
The outer case has an upper surface formed in a convex surface at a substantially central portion in the width direction of the chemical solution supply apparatus, and / or a lower back surface formed in a concave surface at a substantially central portion in the width direction of the chemical solution supply device. Since it is formed, the shape of the built-in component can be modified and arranged.
In the ninth embodiment, as shown in FIG. 37, the substantially central portion of the lower back surface of the lower lid 303 is formed into a concave surface, so that the lower portion of the reservoir 309 can be extended downward. FIG. 30 is a cross-sectional view of the main part of the chemical liquid supply apparatus 301 corresponding to FIG.
In FIG. 30, the left and right ends in the longitudinal direction of the lower lid 303 are formed so as to protrude downward with respect to FIG. 23, and the left outer end of the reservoir 309 does not overlap the battery 310 in plan view. The lower portion is extended downward to form a lower extension 309g. Therefore, a large capacity of the reservoir 309 can be secured by the lower extension 309g.

  The extension portion of the reservoir 309 is not limited to the above, and may be another portion. For example, if both ends in the narrow direction of the lower lid 303 protrude downward with respect to FIG. 23, both ends in the narrow direction that do not overlap the battery 310 in the plan view in the reservoir 309 are on the lower side. It may be extended. Alternatively, when the substantially central side in the longitudinal direction of the upper surface of the upper lid 302 is convex, an upper portion corresponding to the convex shape of the reservoir 309 is projected upward along the convex shape on the central side. You may do it. Alternatively, when the substantially center side in the narrow direction of the upper surface of the upper lid 302 is formed in a convex shape, the upper side of the reservoir 309 may be formed so as to protrude corresponding to the convex shape.

[Tenth embodiment]
Next, a tenth embodiment will be described with reference to FIG.
The outer case has an upper surface formed as a convex surface at a substantially central side in the width direction of the chemical liquid supply device, and / or a lower back surface formed as a concave surface at a substantially central side in the width direction of the chemical liquid supply device. Therefore, the shape of the built-in component can be modified and arranged.
In the tenth embodiment, as shown in FIG. 31, the vertical axis of the reservoir 309 is inclined with respect to the vertical axis 311h of the chemical solution supply device 301, and the vertical axis of the micropump 312 is similarly inclined. It is shown. FIG. 31 is a cross-sectional view of a main part corresponding to FIG. The vertical axis 311h of the chemical liquid supply device 301 indicates a vertical axis that is orthogonal to the flat surface when the chemical liquid supply device 301 is placed on a flat plane.

  In FIG. 31, the lower back surface of the lower lid 303 is formed in a concave surface so that the central portion in the longitudinal direction is concave. A central lower back surface 303c is formed on the center side of the lower back surface of the lower lid 303, a left lower back surface 303d is formed on the left side, and a right lower back surface 303e is formed on the right side. It is formed in a straight line. The center lower back surface 303c, the left lower back surface 303d, and the right lower back surface 303e may be formed in an arc shape. On the other hand, the upper surface of the upper lid 302 is also formed with a central upper surface 302c on the center side, a left upper surface 302d on the left side, and a right upper surface 302e on the right side. The central upper surface 302c, the left upper surface 302d, and the right upper surface 302e are It is formed in a substantially arc shape. The center upper surface 302c, the left upper surface 302d, and the right upper surface 302e may be formed in a straight line.

Here, the vertical axis 309h of the reservoir 309 is substantially perpendicular to the left lower back surface 303d of the lower lid 303. Therefore, the vertical direction of the chemical solution supply device 301 is perpendicular to the central lower rear surface 303c of the lower lid 303. It tilts to the left with respect to the axis 311h and has a reservoir tilt angle ε1. Similarly, the vertical axis 312a of the micropump 312 is substantially perpendicular to the lower right back surface 303e of the lower lid 303. Therefore, the upper and lower sides of the chemical solution supply device 301 are perpendicular to the central lower rear surface 303c of the lower lid 303. It tilts to the right with respect to the direction axis 311h and has a micropump tilt angle ε2.
For this reason, the reservoir 309 and the micro pump 312 are arranged with their respective vertical axes inclined so as to be almost perpendicular to the concave surface on the lower back surface of the lower lid 303 or the convex surface of the upper surface of the upper lid 302 which is an exterior case. Therefore, it is possible to arrange the gaps among the reservoir 309, the micropump 312 and the inner surface of the outer case with a small amount, and a thin chemical supply device can be provided. In other words, since the upper surface of the outer case is a convex surface and the lower back surface is a concave surface, the animal is less uncomfortable and minimizes damage, while achieving a low thickness as described above. It is possible to reduce damage to animals.

[Eleventh embodiment]
Next, an eleventh embodiment will be described with reference to FIG.
The shapes of the upper and lower surfaces of the outer case are not limited to the above.
The eleventh embodiment is configured as shown in FIG.
In FIG. 32A, in the longitudinal direction, substantially the center of the upper surface of the upper lid 302 is formed as a convex surface, and the lower rear surface of the lower lid 303 is formed in a straight line. (B) Contrary to (A), the upper surface of the upper lid 302 is formed in a straight line, and the substantially central side of the lower surface of the lower lid 303 is formed in a concave shape. In (C), in the narrow direction, the substantially central side of the upper surface of the upper lid 302 is formed as a convex surface, and the lower rear surface of the lower lid 303 is formed in a straight line shape. In (D), contrary to (C), the upper surface of the upper lid 302 is formed in a linear shape, and the substantially central side of the lower surface of the lower lid 303 is formed in a concave shape.
In addition to the above, the above combination may be other than that. With this configuration, when the chemical solution supply apparatus is incorporated in the animal, the sense of incongruity to the animal is further eliminated.

In the present invention, the inclined surface is not limited to the form described in the sixth embodiment to the eleventh embodiment, but from the skin-side corresponding surface that is the surface of the upper lid 302 to the rear surface that is the surface surface of the lower lid 303. What is necessary is just to be formed in at least one part of the outer wall which faces. For example, in the sixth embodiment of FIG. 20, all of the outer walls (side surfaces) are inclined surfaces 301d, 301e, 301f, and 301g. Instead, the inclined surfaces 301d and 301e are left as inclined surfaces, and the other outer walls are inclined. As described above, the configuration may be such that β (21, 21 is 0 degrees) may not be used. In this case, the outer wall in the wide direction where the inclined surfaces 301f and 301g were formed is formed in a substantially vertical surface. This substantially vertical plane becomes a gripping vertical plane described later.
According to this embodiment, after the chemical solution supply device 301 is implanted subcutaneously, it becomes easy to grasp the substantially vertical surface (the vertical surface for gripping) through the skin, and the embedded chemical solution supply device 301 can be easily fixed. Accordingly, when the reservoir 309 is replenished with the chemical solution, the position of the liquid injection port 308 can be easily fixed, and the workability can be improved by clarifying the position where the injection needle is inserted.

Alternatively, the inclined surfaces 301d, 301e, 301f, and 301g may be left as inclined surfaces, and the other outer walls may not be inclined (α11, 21 is 0 degrees).
Further, any one of the inclined surfaces 301d, 301e, 301f, and 301g may be formed as an inclined surface, and the other outer wall may be formed as a substantially vertical surface without being inclined.
Moreover, the form provided with the vertical surface for a grip as mentioned above in a part of inclined surface may be sufficient. That is, when described using the sixth embodiment of FIG. 20, the intermediate portions of the inclined surfaces 301f and 301g may be partially formed substantially vertically (β11 and 21 are 0 degrees). In this case, the inclined surfaces 301f and 301g are formed on both sides of the substantially vertical surface, and the substantially vertical surface becomes the gripping vertical surface.

Next, modifications and application examples applicable to each embodiment will be described.
[Modification 1]
FIG. 33 is a main cross-sectional view of the liquid injection port 208 showing a modified example of the liquid injection port 208 (including the liquid injection port 308).
The liquid injection port protrusion 208a in FIG. 16 has a color tone integrated with the upper lid 202 in FIG. 16, but the liquid injection port protrusion 208a in FIG. 33 is different from the color tone of the upper lid 202.
Although the color tone of the upper lid 202 is formed of a colorless transparent material, the liquid injection port protrusion 208a in FIG. 33 is formed of red. Therefore, the liquid injection port protrusion 208a may be a separate member from the upper lid 202, and the contact surface of both may be joined with an adhesive such as waterproofing, or a red synthetic resin is formed on the upper lid 202 for injection. The liquid port protrusion 208a may be integrally formed with resin.
As described above, since the liquid injection port protrusion 208a is red and different from the color tone of the upper lid 202, when the liquid medicine supply device 201 is implanted under the skin of a laboratory animal, the liquid injection port protrusion 208a The red color is easier to see from the outside. The experimenter can easily recognize the location of the liquid injection port 208 and easily insert the liquid injection tool into the liquid injection port 208.
In this case, the color tone of the liquid injection port protrusion 208a is not limited to the red color, and may be any color tone that can be easily recognized by the experimenter from the outside, such as a blue color or a black color. good.
In FIG. 33, at the upper end of the liquid injection port frame 220, a drop prevention collar 220d for preventing the liquid injection port packing 221 from coming out is provided.
Except for the above, they are formed in the same manner as in FIG.

[Modification 2]
FIG. 34 is a main cross-sectional view of the liquid injection port 208 showing another modification of the liquid injection port 208 (including the liquid injection port 308).
In the liquid injection port 208 of FIG. 34, a guide inclined surface 220e is provided at the upper end of the liquid injection port frame 220 to serve as a guide when the liquid injection tool is inserted from the outside. The inclination angle δ of the guide inclined surface is formed in a direction extending upward, and is preferably 5 degrees to 30 degrees, more preferably 10 degrees to 20 degrees.

[Modification 3]
FIG. 35 is a main cross-sectional view of the liquid injection port 208 showing still another modified example of the liquid injection port 208 (including the liquid injection port 308).
In FIG. 35, the liquid injection port 208 has no protrusion from the upper surface of the upper lid 202.
That is, the injection port protrusion 208a does not exist as shown in FIGS.
Therefore, the upper end of the liquid injection port frame 220 is formed so as to be held at a height below the upper surface of the upper lid 202.
If the liquid injection port 208 does not protrude from the upper surface of the upper lid 202 in this way, it is not necessary to protrude the skin of the experimental animal, thereby reducing the burden on the experimental animal.
However, since it becomes difficult for an experimenter to find the location of the liquid injection port 208 when the chemical liquid is replenished, it is necessary to make the color tone of the liquid injection port frame 220 different from the color tone of the upper surface of the upper lid 202 as in Modification 1. .

[Modification 4]
The micropump 212 (312) is not limited to the type described above. In short, any chemical solution may be used as long as it is appropriately supplied and discharged from the reservoir 209 (309).
For example, the structures of the rotation drive unit 214 (314) and the cam unit 217 (317) may be those disclosed in Japanese Patent No. 3702901.
The rotation driving unit 214 (314) uses a timepiece movement for driving a wristwatch of a wristwatch, and the stepping motor is step-driven in accordance with a driving signal and a control program determined in advance by the driving control means, so that the cam unit However, the rotation drive unit may be other than that.
Also, any structure or method may be used for the pump structure that sequentially presses the tube 211 (311) to deliver the chemical solution. For example, the tube is localized by a metal ball that rotates on the tube while maintaining a plurality of predetermined intervals. The micropump may be such that the chemical liquid existing between the tubes at predetermined intervals of the plurality of balls is discharged sequentially.

[Modification 5]
The battery 210 (310) in each embodiment may be a disposable type primary battery such as a silver oxide battery or a lithium battery, but may be a rechargeable secondary battery. In that case, it is necessary to form a charging terminal on, for example, the lower lid 203 (302) of the chemical solution supply apparatus 201 (301). The secondary battery can be charged by connecting the connection terminal of the external charger to the charging terminal, and the chemical solution supply device 201 (301) can be used or reused for a long time. In addition, the battery 210 (310) in each said embodiment used what outputs the DC voltage of 1.5V. Note that another power source may be used instead of the battery.

[Modification 6]
In addition to the waterproof treatment described above, a waterproof structure may be employed so that the body fluid of the experimental animal does not enter the chemical solution supply apparatus.
For example, in each embodiment, the contact surfaces on the outer peripheral side of the upper lid 202 (302) and the upper base frame 204 (304), and the outer peripheral side of the upper base frame 204 (304) and the lower base frame 205 (305). Minute protrusions are formed on the entire circumference of the chemical solution supply device on at least one of the contact surfaces and the contact surfaces of the lower base frame 205 (305) and the lower lid 203 (303). . The minute projections are formed on the inner peripheral side of the outer case fixing screw 213 (313) to be fixed by screwing. After that, by screwing the outer case fixing screw 213 (313), the contact surfaces are brought into pressure contact with each other, and the upper lid 202 (302), the upper base frame 204 (304), the lower base frame 205 (305), and the lower lid 203 are pressed. Since (303) is formed of a synthetic resin, the minute projections are crushed by the pressure contact and have a waterproof structure.
Further, the fine protrusions may be fused by heat generated by ultrasonic vibration.
In the above case, the injection opening 208b (308b) of the injection port 208 (308), the upper outer peripheral wall surface of the injection port frame 220 (320), the inner wall surface of the injection port frame 220 (320), and the injection port packing 221. (321), an outer peripheral wall surface of the tube 211 (311), an outer peripheral surface of the exposed tube portion 211b (311b) at the right end, and a tube exposure opening 223 (on the right side wall of the upper lid 202 (302) and upper base frame 204 (304)). It is preferable to adhere to the inner peripheral wall surface of H.323) with the aforementioned ultraviolet curable adhesive.

As another waterproof structure, a waterproof packing structure in which the waterproof packing is pressed against the contact portion of each member can also be applied.
For example, the outer contact surface between the upper lid 202 (302) and the upper base frame 204 (304), the outer contact surface between the upper base frame 204 (304) and the lower base frame 205 (305), and the lower base The contact surface between the frame 205 (305) and the lower lid 203 (303), the contact surface between the injection opening 208b (308b) of the injection port 208 (308) and the upper outer periphery of the injection port frame 220 (320), On the outer peripheral surface of the exposed tube portion 211b (311b) at the right end of the tube 211 (311) and the inner peripheral wall surface of the tube exposure opening 223 (323) provided on the right side wall of the upper lid 202 (302) and the upper base frame 204 (304). If a waterproof packing arrangement groove made of synthetic rubber is formed around the circumference, the waterproof packing is inserted into the arrangement groove and then assembled, and when the above-mentioned exterior case fixing screw 213 (313) is screwed in, each waterproof packing is compressed. From, so that the waterproof structure can be obtained.

[Modification 7]
In the chemical solution supply device 201 (including the chemical solution supply device 301), when the chemical solution is supplied to the reservoir 209 having the above-described material and thickness through the liquid injection port 208 as described above, and discharged by the micropump 212. In this case, the external shape of the reservoir 209 is set so as to expand and contract.
For example, when the reservoir 209 is filled with a chemical solution, the reservoir 209 expands to have an expanded outer shape, such as a plan view shape or a side view shape as shown in FIGS. Thereafter, when the chemical liquid is discharged by the micropump 212, the reservoir 209 gradually contracts, and the outer shape thereof also exhibits a contracted outer shape.
If the external shape of the reservoir 209 is set so as not to be deformed even if the liquid medicine is discharged from the reservoir 209 by the micropump 212, a space portion corresponding to the volume of the discharged liquid medicine is formed in the reservoir 209. Will be. The space is almost in a vacuum state. If the supply operation of the chemical solution by the micropump 212 is continued thereafter, the chemical solution becomes difficult to be discharged, and it becomes difficult to control the supply of the chemical solution (supply amount, supply speed, etc.). This is because the reaction force due to the vacuum state of the above-described space in the reservoir 209 acts on the chemical solution supply force of the micropump 212. Therefore, as the chemical solution is discharged from the reservoir 209, the reaction force described above increases, and it becomes difficult to control the supply of the chemical solution.

Therefore, in order to improve the difficulty of controlling the supply of the chemical solution described above, it is preferable that the reservoir 209 can be contracted as the chemical solution is discharged from the reservoir 209.
FIG. 36 shows a modification in which the reservoir 209 is configured to be able to contract.
FIG. 36 is a cross-sectional view seen from substantially the same direction as FIG. The left and right directions of the reservoir 209 and the battery 210 are shown in FIG. 14 without being omitted.
36, the reservoir 209 is configured in the same manner as in FIG. 14, and the material and thickness thereof are substantially the same as those in FIG.
In the illustration of FIG. 36, since the chemical liquid is almost discharged from the reservoir 209 by the micropump 212, the upper wall 209d of the reservoir 209 hangs down to the suspending position 209e indicated by a solid line. The suspended position 209e is suspended to a position almost in contact with the lower wall 209f of the reservoir 209. The chemical solution in this state is discharged by the micropump 212 and is in a state where only a small amount exists in the reservoir 209.

On the other hand, a deformable upper lid portion 230 that can be elastically deformed is formed in a planar region of the upper lid 202 that faces the reservoir 209 in plan view.
The deformed upper lid portion 230 is made of the same material as the reservoir 209. Specifically, it is excellent in chemical resistance, elasticity, strength, and gas barrier properties, and has an rubber hardness of about 25 to 40 degrees. It is a vinyl-based or silicon-based synthetic resin, and its thickness is 0.2 mm.
The outer peripheral surface 230b of the outer peripheral thick wall portion 230a on the outer periphery is bonded to the inner surface of the opening of the upper cover 202 by an adhesive or by heat fusion to the above-described deformed upper cover portion 230, thereby ensuring waterproofness. ing. The center of the deformed upper lid portion 230 in the plan view is a central thin portion 230c.

  As shown in FIG. 36, when the chemical liquid in the reservoir 209 is almost discharged, the pressure inside the deformed upper lid portion 230, that is, the pressure inside the chemical liquid supply apparatus 201 is decreased. The upper side wall 209d tends to be deformed downward, but the downward pressure is prevented from being deformed downward due to the pressure drop. At that time, the central thin-walled portion 230c is elastically deformed inward (downward in FIG. 36) due to the pressure drop inside thereof and hangs down to a lower position 230d. Therefore, the inner pressure of the thin portion 230c hardly decreases, and thus the upper wall 209d of the reservoir 209 is not prevented from drooping. Therefore, the pressure in the reservoir 209 is prevented from decreasing, and the chemical liquid is smoothly discharged by the micropump 212.

In addition, when the reservoir 209 is filled with the chemical solution, the central thin portion 230c of the deformed upper lid portion 230 is located above as shown by a two-dot chain line in FIG. It has a bellows shape. This is to facilitate elastic deformation to the lower position 230d. However, the shape of the thin portion 230c when the reservoir 209 is filled with the chemical solution is not limited to the bellows, but may be horizontal. In short, any material and shape that can be easily elastically deformed to the lower position 230d may be used.
The configuration of the elastically deformable deformable upper lid portion 230 provided on the upper lid 202 is not limited to the above-described configuration, and the chemical liquid corresponds to the pressure drop in the reservoir 209 when the chemical liquid in the reservoir 209 is discharged. Any structure may be used as long as the outer case portion of the supply device 201 is elastically deformed inward. For example, an opening that communicates with the outside may be provided in the exterior case portion of the chemical solution supply device 201 so as to communicate with the outer space of the reservoir 209 inside the upper lid 202. For example, in the upper lid 202 of FIGS. 13 and 14, a small hole is provided at a position overlapping the reservoir 209 in plan view. The small hole may be provided at a position overlapping the reservoir 209 of the lower lid 203 in plan view.
The reservoir 209 is set so that the outer shape of the reservoir 209 hardly changes when the chemical solution is supplied through the injection port 208 as described above and when the reservoir is discharged by the micropump 212. Also good. In this case, the material of the reservoir 209 is selected so as not to be elastically deformed.

It should be noted that the present invention is not limited to the above-described embodiment, and modifications, improvements, and the like within a range in which the object of the present invention can be achieved (a range that does not change the gist of the present invention) are included in the present invention. .
That is, the present invention is mainly illustrated and described with respect to specific embodiments, but the shape of the embodiments described above is not deviated from the technical idea and scope of the present invention. Various modifications can be made by those skilled in the art in terms of materials, combinations, other detailed configurations, and processing methods between manufacturing processes.
Therefore, the description limited to the shape, material, manufacturing process and the like disclosed above is an example for easy understanding of the present invention, and does not limit the present invention. Descriptions of the names of members from which some or all of the limitations such as materials and combinations are removed are included in the present invention.

For example, in the above-described embodiment, the fluid transporting device mounted in the living body has been described. However, the fluid transporting device can be mounted not only in the living body but also in other devices and apparatuses. In particular, since the fluid transport device has a sealed structure, the fluid transport device is suitable as a fluid transport device used in a fluid or in a place with a lot of dust.
Therefore, according to the above-described embodiment, it is possible to achieve a reduction in size and thickness, waterproofness that can be mounted in a living body, and additional injection of a chemical solution at an arbitrary timing, It is possible to provide a fluid transport device that can continuously and continuously flow and has high safety.
Further, in the above-described embodiment, the outer shape is formed in a substantially rectangular shape in plan view, but is not limited thereto, and is square, circular, elliptical, oval, and semicircular in plan view. Further, it may be spherical.
Which external shape is applied is selected depending on the place of use, the situation, etc. For example, in the case of the type embedded under the skin, the external shape that does not give a sense of incongruity to the living body (does not affect) is selected. The

The fluid transport device 1 of the present invention can be miniaturized and can stably flow at a very small flow rate, so that the fluid transport device 1 is suitable for medical use such as the development of a new drug, treatment, etc. .
Moreover, in various mechanical devices, it can be mounted in the device or outside the device and used for transporting fluids such as water, saline, chemicals, oils, fragrances, inks and gases. Furthermore, the fluid transport device alone can be used for the flow and supply of the fluid.
Moreover, the chemical | medical solution supply apparatuses 201 and 301 of this invention can be embedded under the skin of a laboratory animal as mentioned above, and can be used for the animal incident of a chemical | medical solution. The chemical solution is not used for the development of a new drug for medical use or for the development of a nutrient for small animals, and is not limited to its use.
Further, the chemical solution supply devices 201 and 301 of the present invention are not limited to devices for implantation in laboratory animals, but are also applied to applications for implantation under the skin of a human body. For example, they are medical therapeutic drug solutions or nutrient solutions. For example, it may be injected into a blood vessel or muscle.

Sectional drawing which shows the basic composition of the fluid transport apparatus which concerns on 1st Embodiment of this invention. The top view which shows the basic composition of the fluid transport apparatus which concerns on 1st Embodiment of this invention. The top view which shows the movement for watches as a drive transmission mechanism which concerns on 1st Embodiment of this invention. Sectional drawing which shows the cross-section of the train wheel and fluid transport mechanism of the drive transmission mechanism which concerns on 1st Embodiment of this invention. Sectional drawing shown about the structure in connection with injection | pouring of the fluid which concerns on 1st Embodiment of this invention, and outflow. The top view shown about the effect | action of the fluid transport apparatus which concerns on 1st Embodiment of this invention. The top view which shows the structure of the fluid transport apparatus which concerns on 2nd Embodiment of this invention. It is a side view of the fluid transport apparatus which concerns on 2nd Embodiment of this invention, Comprising: (A) is a narrow side view seen from the narrow side, (B) is a wide side view seen from the wide side. It is a reservoir frame which concerns on 2nd Embodiment of this invention, (A) is a top view, (B) is a front view, (C) is a side view. It is an external view which shows the external appearance of the chemical | medical solution supply apparatus which concerns on 3rd Embodiment of this invention, Comprising: (A) is the downward view side view seen from the lower side of this chemical | medical solution supply apparatus, (B) is seen from the upper side. (C) is a right side view as viewed from the right side of (A), and (D) is a left and right side view as viewed from the left side of (A). It is an enlarged view of the right side part in (A) of Drawing 10 in a chemical solution supply device concerning a 3rd embodiment of the present invention. The top view of the chemical | medical solution supply apparatus in 3rd Embodiment of this invention seen from the paper surface upper part of (A) of FIG. FIG. 13 is a cross-sectional view of a main part of a chemical liquid supply device according to a third embodiment of the present invention at the position A1-A1 in FIG. Sectional drawing of the principal part of the chemical | medical solution supply apparatus in 3rd Embodiment of this invention in the BB position in FIG. The principal part sectional drawing of the micropump part of the chemical | medical solution supply apparatus in 3rd Embodiment of this invention in FIG. The expanded sectional view of the liquid injection port of the chemical | medical solution supply apparatus in 3rd Embodiment of this invention. The top view of the chemical | medical solution supply apparatus in 4th Embodiment of this invention. FIG. 18 is a main cross-sectional view of a chemical liquid supply device according to a fourth embodiment of the present invention at the CC position in FIG. 17. The principal part top view of the chemical | medical solution supply apparatus in 5th Embodiment of this invention. It is an external view which shows the external appearance of the chemical | medical solution supply apparatus which concerns on 6th Embodiment of this invention, Comprising: (A) is the downward view side view seen from the lower side surface of this chemical solution supply apparatus, (B) is seen from the upper side surface. (C) is a right side view as viewed from the right side of (A), and (D) is a left and right side view as viewed from the left side of (A). It is an enlarged view of the right side part in (A) of Drawing 20 in a chemical solution supply device concerning a 6th embodiment of the present invention. The top view of the chemical | medical solution supply apparatus in 6th Embodiment of this invention seen from the paper surface upper part of FIG. 20 (A). The principal part sectional drawing of the chemical | medical solution supply apparatus in 6th Embodiment of this invention in the A2-A2 position in FIG. The principal part sectional drawing of the chemical | medical solution supply apparatus in 6th Embodiment of this invention in the B1-B1 position in FIG. The principal part sectional drawing of the micropump part of the chemical | medical solution supply apparatus in 6th Embodiment of this invention in FIG. The expanded sectional view of the liquid injection port of the chemical | medical solution supply apparatus in 6th Embodiment of this invention. The top view of the chemical | medical solution supply apparatus which concerns on 7th Embodiment of this invention. FIG. 28 is a main cross-sectional view of a chemical solution supply apparatus according to a seventh embodiment of the present invention at the C1-C1 position in FIG. The principal part top view of the chemical | medical solution supply apparatus which concerns on 8th Embodiment of this invention. Sectional drawing of the principal part of the chemical | medical solution supply apparatus which concerns on 9th Embodiment of this invention. Sectional drawing of the principal part of the chemical | medical solution supply apparatus which concerns on 10th Embodiment of this invention. It is an external view which shows the external appearance of the chemical | medical solution supply apparatus which concerns on 11th Embodiment of this invention, Comprising: (A) is the downward view side view seen from the lower side surface of this chemical solution supply apparatus, (B) is seen from the upper side surface. (C) is a right side view as viewed from the right side of (A), and (D) is a left and right side view as viewed from the left side of (A). The principal part sectional drawing of the modification 1 of the injection port part of this invention. Sectional drawing of the principal part of the modification 2 of the injection port part of this invention. Sectional drawing of the principal part of the modification 3 of the injection port part of this invention. The principal part sectional drawing in the modification 7 around the reservoir | reserver part of this invention.

Explanation of symbols

  1: fluid transport device, 3: drive transmission mechanism, 4: battery as power source, 13: upper lid, 16: lower lid, 20: first cam, 30: second cam, 40-46: finger, 50: tube, 60: reservoir, 80: valve (port), 160: fluid transport device, 161: exterior case, 162: fluid transport mechanism (micropump), 167: injection port (port), 169: inclined portion, 170: reservoir, 170a: bottom surface, 180: reservoir frame, 180a: bottom, 180b, 180c: notch, 181: hook, 182: guide surface, 183: collar, 190: opening, 191: step, 192: mounting portion, 201 : Chemical solution supply device (fluid transport device), 201a: intermediate point in the narrow width direction, 201b: predetermined range width in the narrow width direction, 201c: maximum width in the narrow width direction, 201d: longitudinal Side inclined surface, 201e: Longitudinal right inclined surface, 201f: Width left inclined surface, 201g: Width right inclined surface, 202: Upper lid, 202a: Arc-shaped portion, 202b: Arc-shaped portion, 203: Lower lid, 203a: Arc-shaped portion, 203b: Arc-shaped part, 204: Upper base frame, 205: Lower base frame, 206: Exterior case, 207: Thread hook part (mounting part), 207a: Hole in the thread hook part, 208: Injection port (port), 208a: Injection port protrusion, 208b: Injection opening, 208c: Inclined surface, 208d: Center position of injection port, 209: Reservoir, 209a: Injection port connection, 209b: Connection pipe connection, 209c: Chemical solution Storage section, 209d: upper wall of reservoir, 209e: hanging position of upper wall, 209f: lower wall of reservoir, 210: battery, 211: tube, 211a: arc-shaped tube Part 211b: exposed tube part 211c connection pipe attachment part 212: micropump 213: exterior case fixing screw 214: (micropump) rotational drive part 215: first cam 216: second cam 217: Cam part, 218: Pressing pin, 219: Guiding foot, 220: Injection port frame, 220a: Space part, 220b: Connection cylinder part, 220c: Communication path, 220d: Pull-out prevention collar, 220e: Guide inclined surface 221: Injection port packing 222: Connection pipe 223: Tube exposure opening 224: Tube storage part 224a: Arc-shaped tube part support wall 225: IC 226: Circuit board 227: Circuit board fixing screw 228: External signal input port, 229: Input pin, 230: Deformation upper cover part, 230a: Outer peripheral thick part of deformation upper cover part, 230b: Outer periphery The outer peripheral surface of the thick portion, 230c: the central thin portion, 230d: the hanging position of the central thin portion, 301: chemical supply device (fluid transport device), 301a: intermediate point in the narrow direction, 301b: narrow direction Predetermined range width, 301c: maximum width in the narrow direction, 301d: long left inclined surface, 301e: long right inclined surface, 301f: wide left inclined surface, 301g: wide right inclined surface, 301h: vertical axis, 302: upper lid, 302a: Arc-shaped portion, 302b: Arc-shaped portion, 302c: Center upper surface, 302d: Left upper surface, 302e: Right upper surface, 303: Lower lid, 303a: Arc-shaped portion, 303b: Arc-shaped portion, 303c: Center Lower back surface, 303d: Left lower back surface, 303e: Right lower back surface, 304: Upper base frame, 305: Lower base frame, 306: Exterior case, 307: Thread hook part (attachment part), 307a: Hole in thread hook part 3 8: Injection port (port), 308a: Injection port protrusion, 308b: Injection opening, 308c: Inclined surface, 308d: Center position of injection port, 309: Reservoir, 309a: Injection port connection, 309b : Connection pipe connection part, 309c: Chemical solution storage part, 309d: Reservoir upper side wall, 309e: Upper wall hanging position, 309f: Reservoir lower wall, 309g: Lower extension part, 309h: Vertical axis of reservoir, 310: Battery, 311: Tube, 311a: Arc-shaped tube portion, 311b: Exposed tube portion, 311c: Connection pipe mounting portion, 312: Micro pump, 312a: Vertical axis of micro pump, 313: Exterior case fixing screw, 314 : Rotation drive part (of micro pump) 315: First cam 316: Second cam 317: Cam part 318: Pressing pin, 319: Guide foot, 320: Injection port frame, 320a: Space portion, 320b: Connection tube portion, 320c: Communication passage, 321: Injection port packing, 322: Connection pipe, 323: Tube exposure Opening, 324: tube storage portion, 324a: arcuate tube portion support wall, 325: IC, 326: circuit board, 327: circuit board fixing screw, 328: external signal input port, 329: input pin, α1: inclined surface 201d , Α2: inclination angle of the inclined surface 201e, β1: inclination angle of the inclined surface 201f, β2: inclination angle of the inclined surface 201g, γ: inclined surface inclination angle of the injection port projection, δ: injection port frame H: Thickness of the chemical solution supply device, O: Center of rotation of the cam portion, h1: Height of the thread hook portion, h2: Height of the tip of the injection port protrusion, d1: Injection port Tip of protrusion End outer diameter, d2: inner diameter of introduction opening, d3: outer diameter of injection port packing, d4: inner diameter of space, e1: longitudinal tangent of upper end, e2: longitudinal tangent of lower end, e3: right side Narrow width direction tangent of the end, e4: narrow width direction tangent of the left end, α11: inclination angle of the inclined surface 301d, α21: inclination angle of the inclined surface 301e, β11: inclination angle of the inclined surface 301f, β21: inclined surface 301 g of inclination angle, γ1: inclined surface inclination angle of the injection port protrusion, ε1: reservoir inclination angle, ε2: micropump inclination angle, H1: thickness of the chemical supply device, O1: rotation center of the cam part, h11: Height of thread hook part, h21: height of tip of liquid injection port protrusion, h31: height of convex part on upper surface, h41: depth of concave part on lower back, d11: liquid injection port protrusion Tip outer diameter, d21: inner diameter of introduction opening, d31: injection port port Kin outer diameter, d41: inner diameter of space, e11: longitudinal tangent of upper end, e21: longitudinal tangent of lower end, e31: narrow tangent of right end, e41: narrow tangent of left end .

Claims (24)

A compact fluid transporting device that continuously squeezes fluid by squeezing a tube having elasticity,
A fluid transport mechanism having a plurality of fingers for closing the tube, and a cam for sequentially pressing the fingers from the fluid inflow side to the outflow side;
A drive transmission mechanism for transmitting a driving force to the fluid transport mechanism;
A reservoir containing a fluid communicating with the inflow side of the tube;
A port for injecting fluid into the reservoir;
A power supply for supplying power to the drive transmission mechanism,
The fluid transport mechanism and the drive transmission mechanism are disposed to overlap, and the reservoir is disposed at a position where the fluid transport mechanism and the drive transmission mechanism do not overlap,
At least the fluid transport mechanism, the drive transmission mechanism, and the power source are stored in a sealed space of an outer case constituted by an upper lid and a lower lid. The fluid transport device according to claim 1,
The fluid transport device according to claim 1, wherein the reservoir is stored in a sealed space of the outer case. The fluid transport device according to claim 1,
The fluid transport device according to claim 1, wherein the reservoir is held outside the outer case in an inclined state with respect to the surface. The fluid transport device according to claim 1 or 3,
The fluid transport device according to claim 1, wherein the reservoir is attached to the outside of the outer case in a detachable state via a reservoir frame. The fluid transport device according to any one of claims 1 to 4,
The drive transmission mechanism is composed of a watch movement including a step motor and a train wheel, and the cam is inserted into the shaft portion of the hour wheel of the train wheel protruding in the direction of the fluid transport mechanism. A fluid transport device. The fluid transport device according to any one of claims 1 to 5,
The fluid transport device according to claim 1, wherein the port is disposed through the upper lid. The fluid transport device according to any one of claims 1 to 6,
The fluid inflow port portion communicating with the tube provided in the reservoir and the fluid inlet port communicating with the port are disposed at positions separated from each other so that the fluid flows inside the reservoir. Fluid transport device. The fluid transport device according to any one of claims 1 to 7,
The fluid transport device according to claim 1, wherein the reservoir comprises a deformable bag. The fluid transport device according to any one of claims 1 to 8,
The fluid transport device according to claim 1, wherein a planar shape of the outer case including the upper lid and the lower lid is an oval shape, and an outer peripheral portion is formed in a gentle streamline shape. The fluid transport device according to any one of claims 1 to 9,
The fluid transport device according to claim 1, wherein an end portion of the tube on a fluid outflow side extends along a shape of an outer peripheral portion of the upper lid. The fluid transport device according to any one of claims 1 to 10,
The fluid injection plug provided in the port is made of an elastic material, and when the injection needle is inserted and fluid is injected into the reservoir and the injection needle is removed, the injection is performed. A fluid transporting device characterized in that a portion where a needle is inserted is sealed by the elasticity of the fluid injection plug itself. A fluid transport device used under the skin;
An exterior case,
A port having an injection opening that is exposed to the outside of the outer case and can inject fluid from the outside;
A reservoir for storing fluid injected from the port;
A fluid conducting portion communicating with the reservoir to conduct fluid;
A micropump for supplying the fluid to the outside via the fluid conducting portion;
A battery for supplying power to the micropump,
The exterior case has a skin side corresponding surface that corresponds to the skin side when embedded under the skin,
The fluid transport device according to claim 1, wherein the port is disposed on the skin side corresponding surface. The fluid transport device according to claim 12, wherein
The reservoir and the micropump are arranged apart from each other in plan view,
The fluid transport device according to claim 1, wherein the port is disposed between the reservoir and the micropump in a plan view. The fluid transport device according to claim 12 or 13,
The fluid transport device according to claim 1, wherein the port includes a projecting portion projecting from the outer case, and the injection opening is formed in the projecting portion. The fluid transport device according to any one of claims 12 to 14,
The fluid transport device according to claim 1, wherein the battery overlaps with the reservoir in a plan view and is disposed on the opposite side of the port with the reservoir in a cross-sectional view. The fluid transport device according to any one of claims 12 to 15,
The fluid transport device according to claim 1, wherein the port is disposed at a position that does not overlap the battery in plan view. The fluid transport device according to any one of claims 12 to 16,
An IC for controlling the operation of the micropump, a circuit board on which the IC is mounted, and a signal supply port disposed in the exterior case so as to supply a control program for controlling the operation of the micropump to the IC And a fluid transport device. The fluid transport device according to any one of claims 12 to 17,
An attachment part for attaching to an installation object is formed in the exterior case, The fluid transportation device characterized by things. The fluid transport device according to claim 12, wherein
The fluid transporting device according to claim 1, wherein the exterior case includes an inclined surface on at least a part of an outer wall from the skin-side corresponding surface toward the back surface. The fluid transport device according to claim 19,
The fluid transporting device according to claim 1, wherein the outer case includes a vertical gripping surface on an outer wall from the skin-side corresponding surface toward the back surface. The fluid transport device according to claim 19 or 20,
The inclined surface is a narrow side outer wall formed in the narrow direction at one end in the wide direction in the outer case, and a narrow side outer wall formed in the narrow direction at the other end in the wide direction. The fluid transporting device is characterized by being formed so as to be inclined so that the width in the wide direction becomes narrower from the back surface of the exterior case toward the corresponding surface on the skin side. The fluid transport device according to any one of claims 19 to 21,
The inclined surface includes a wide side outer wall formed in the wide direction at one end in the narrow direction in the outer case, and a wide side outer wall formed in the wide direction at the other end in the narrow direction. A fluid transporting device, wherein the fluid transporting device is formed so as to be inclined so that the width in the narrow direction becomes narrower from the back surface of the outer case toward the corresponding surface on the skin side. The fluid transport device according to claim 12, wherein
The exterior case has at least one of the skin-side corresponding surface formed in a convex surface along the wide direction and the back surface of the skin-side corresponding surface formed in a concave surface along the wide direction. A fluid transportation device comprising: 24. The fluid transport device according to claim 12 or claim 23.
The exterior case includes at least a skin-side corresponding surface formed in a convex surface along a narrow direction and a back surface of the skin-side corresponding surface formed in a concave surface along the narrow direction. A fluid transporting device comprising one side.

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