JP2008230995A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin-lightening cosmetic which contains a 4-methoxysalicylate salt, has properly increased viscosity, has freshness, and is less sticky. <P>SOLUTION: The skin-lightening cosmetic which has properly increased viscosity and freshness and is less sticky is prepared by dissolving gellan gum, a neutralizing agent comprising a cation, and a 4-methoxysalicylate salt, to produce the gel, crushing the gel to produce a fine gel-like composition, and adding the fine gel-like composition to a cosmetic. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a cosmetic containing a fine gel composition obtained by pulverizing a gel. More specifically, the present invention relates to a cosmetic that mixes gellan gum, a neutralizing agent composed of a cation, and 4-methoxysalicylate to form a gel and pulverize the gel to blend a fine gel composition.

Whitening agents used in cosmetics include vitamin C derivatives, arbutin, 4-methoxysalicylate, and the like. Among these, 4-methoxysalicylate is a drug expected to have a high whitening effect. However, when 4-methoxy salicylate is blended, the viscosity of the gel is lowered, and it is difficult to prepare a cosmetic material having an appropriate viscosity. There is a possibility that an agent having an appropriate viscosity can be prepared by increasing the amount of the thickener. However, when the amount of the thickener is increased, there is a drawback that the conventional feeling is not fresh and sticky.

An important factor in evaluating cosmetics is the feeling of use and stability. Attempts have been made to apply gellan gum to a composition for external use because of its unique feeling of use and the fact that it exhibits a thickening action even under electrolyte addition conditions. In recent years, studies have been made to prepare fine gels by adding gels made from gellan gum by adding alkali metal or alkaline earth metal cations such as sodium and calcium, and applying them to thickened external compositions. (See Patent Document 1).
Further, a gel composition containing gellan gum and an electrolyte that releases ammonium ions has been studied. (See Patent Document 2)
However, when 4-methoxysalicylate is simply blended in a prescription system thickened using gellan gum, the viscosity of the gel is lowered, and it is not possible to prepare a cosmetic material that is moderately thickened.
JP 9-20649 A JP 2004-196709 A

  This invention makes it a technical subject to mix | blend 4-methoxy salicylate, and to thicken moderately and to provide the whitening cosmetics with little freshness and stickiness.

  As a result of intensive studies to solve the conventional problems, the present inventors dissolved gellan gum, a neutralizing agent composed of a cation, and 4-methoxysalicylate to form a gel. By blending the pulverized fine gel composition into the cosmetic, it was found that a whitening cosmetic with a moderately thickened viscosity and less stickiness was obtained, and the present invention was completed.

That is, the present invention relates to a cosmetic comprising (a) gellan gum, (b) a neutralizing agent comprising a cation, and (c) 4-methoxysalicylate.
Further, the present invention provides the glycyrrhizic acid dipotassium salt, trimethylglycine, wherein the neutralizing agent (b) is a calcium salt, a magnesium salt, a sodium salt, a potassium salt, or dissociates the salt by dissolving in water. , A cosmetic selected from sodium pyrosulfite, sodium citrate, and potassium lactate.

  According to the present invention, gellan gum, a neutralizing agent composed of a cation, and 4-methoxysalicylate are dissolved to form a gel, and a fine gel composition obtained by pulverizing the gel is blended in cosmetics. Makes it possible to provide a whitening cosmetic with a moderately thickened, fresh and less sticky appearance.

Hereinafter, preferred embodiments of the present invention will be described in detail.
The gellan gum in the present invention is U.S. Pat. S. A. Developed by Kelco, Inc., which is composed of glucose, glucuronic acid and rhamnose produced by Pseudomonas Elodea in a medium containing glucose as the main component (glucose: glucuronic acid: rhamnose = 2: 1: 1). Ratio)), which is mainly composed of heteropolysaccharide. In addition, its molecular weight is about 670,000 to 920,000, and it is an industrial product with high purity that is industrially produced under complete production control. As shown in the following formula, the structural formula is a linear high-molecular polysaccharide composed of repeating 1-3 linked glucose, 1-4 bonded glucuronic acid, 1-4 bonded glucose, and 1-4 bonded rhamnose. is there.

  0.001-1.5 mass% is preferable with respect to the whole external composition, and, as for the compounding quantity of the gellan gum in this invention, 0.005-1.0 mass% is especially preferable. When the blending amount is less than 0.005% by mass with respect to the entire external composition, it becomes substantially difficult to sufficiently gel, and when it exceeds 1.5% by mass with respect to the entire external composition. When a polymer-specific film is formed on the system and applied to the skin

  The neutralizing agent consisting of (b) a cation used in the present invention is not particularly limited as long as it has a function of gelling gellan gum. For example, calcium salt, magnesium salt, sodium salt, potassium salt, or dipotassium glycyrrhizinate, trimethylglycine, sodium pyrosulfite, sodium citrate, potassium lactate, etc., which dissolves in water and dissociates the salt. it can. Of these, calcium chloride salt, magnesium chloride salt, sodium chloride salt and potassium chloride salt are preferably used.

The blending amount of the neutralizing agent comprising a cation in the present invention is preferably 0.001 to 10% by mass with respect to the entire cosmetic, and 0.15 to 50 times by mass with respect to gellan gum. I like it. When the blending amount is less than 0.001% by mass with respect to the entire cosmetic, it becomes substantially difficult to sufficiently gel the entire cosmetic, and when the blending exceeds 10% by mass with respect to the entire cosmetic. When applied to the skin, the feeling of use will be impaired.

  The kind of 4-methoxysalicylate salt used in the present invention is not particularly limited as long as it is a pharmaceutically acceptable salt. For example, an alkali metal such as sodium salt, potassium salt, calcium salt is used. In addition to salts or alkaline earth metal salts, salts such as ammonium salts and amino acid salts can be mentioned. Of these, potassium 4-methoxysalicylate is preferable in that it can provide a gel having high transparency and stability. In the present invention, 4-methoxysalicylate may be blended or 4-methoxysalicylic acid and an alkali compound that forms a salt may be blended separately.

The blending amount of 4-methoxysalicylate in the present invention should be appropriately selected according to the specific dosage form of the external preparation for skin and the balance with other blending components, and is particularly limited. Although it is not, it is preferable that it is 0.001-10.0 mass% with respect to the whole cosmetics, More preferably, it is 0.01-5.0 mass%. When the blending amount of 4-methoxysalicylate is less than 0.001% by mass relative to the entire cosmetic, it is difficult to sufficiently exert the whitening effect, and it is not preferable, and the amount exceeds 10.0% by mass. However, the improvement of the whitening effect commensurate with the increase in the amount of blending is hardly recognized, and the tendency to promote a rather sticky feeling of use is strong, which is not preferable.

In the present invention, gellan is prepared by dissolving gellan gum, a cation neutralizing agent, and 4-methoxysalicylate. A whitening cosmetic can be provided by blending the cosmetic with a fine gel composition obtained by pulverizing the gel using a homomixer or the like.
In addition, when melt | dissolving the neutralizing agent which consists of a cation, and 4-methoxy salicylate at high temperature of 80-95 degreeC, it cools below the temperature which forms a gel, and when a gel is produced, a firmer gel Is preferable.

The cosmetic blended with the pulverized gel may be any of a transparent liquid, a translucent liquid, an O / W emulsified aqueous phase, and a W / O emulsified aqueous phase. It is also possible to blend in a three-phase system in which powders are further dispersed.

  The gel obtained in the present invention is a gel that is stronger than a gel prepared using gellan gum and an ascorbic acid derivative, and has a characteristic that it does not decrease in viscosity at high temperatures and is more fresh and non-sticky.

In the present invention, in addition to the essential components described above, other components that can be usually blended in the external composition can be blended as long as the desired effects of the present invention are not impaired.
For example, hydrocarbons such as liquid paraffin, squalane and petrolatum; fats and oils such as macadamia nut oil, olive koji and lanolin; waxes such as jojoba oil, carnauba wax and candelilla wax; silicones such as dimethylpolysiloxane and methylphenylsiloxane Higher alcohols such as capryl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, cholesterol, phytosterol; higher fatty acids such as capric acid, myristic acid, palmitic acid, stearic acid, behenic acid, lanolin fatty acid, linoleic acid, linolenic acid; Polyethylene glycol, glycerin, 1,
Moisturizers such as 3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, mucopolysaccharide, hyaluronic acid, chondroitin sulfate, chitin, chitosan; lower alcohols such as ethanol; antioxidants such as butylhydroxytoluene, tocopherol, and phytin; Antibacterial agents such as benzoic acid, salicylic acid, sorbic acid, paraoxybenzoic acid alkyl ester, hexachlorophene, and the like can be appropriately blended.

  Amino acids such as glycine, alanine, valine, leucine, threonine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamine, taurine, histidine and their alkali metal salts and hydrochlorides; acyl sarcosine acids (eg, lauroyl sarcosine sodium), glutathione Organic acids such as citric acid, malic acid, tartaric acid and lactic acid; vitamin A and its derivatives; vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 and its derivatives, vitamin B12, vitamin B15 and its derivatives Vitamin B such as α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, etc .; vitamin D; vitamins such as vitamin H, pantothenic acid, panthetin, etc. Nicotinamide, benzyl nicotinate, γ-oryzanol, allantoin, glycyrrhizic acid (salt), glycyrrhetinic acid and its derivatives, hinokitiol, bisabolol, eucalyptol, thymol, inositol, saikosaponin, carrot saponin, hetimasaponin, muclodisaponin Various drugs such as saponins such as pantothenyl ethyl ether, ethinyl estradiol, tranexamic acid, arbutin, cephalanthin, and placenta extract; borage, clara, corn, orange, sage, yarrow, zebra, thyme, thyme, spruce, spruce, birch , Natural extracts extracted with various solvents such as horsetail, loofah, maroonier, yukinoshita, arnica, lily, mugwort, peonies, aloe, gardenia, sawara, etc .; neutralizing agent, Antioxidants, pigments, fragrances, purified water and the like can be appropriately blended.

The cosmetics of the examples and comparative examples described in the table were prepared and evaluated according to the following evaluation criteria. However, the unit of the amount is mass%.
[Manufacturing method] The cosmetics shown in Examples and Comparative Examples were prepared by mixing each raw material with water at room temperature, dissolving by heating to 80 to 95 ° C, and then cooling to room temperature again to prepare a gel. The gel was pulverized using a homomixer or the like.

(1) Evaluation of thickness For each cosmetic, a cosmetic use test was conducted by five specialist panels, and the thickness at the time of application was evaluated based on the following criteria of evaluation points.
◎: Feeling thick (4 out of 5 responded that the evaluation items were excellent)
○: Feeling somewhat thick (2-5 out of 5 responded that the evaluation items were excellent)
△: Almost no feeling of thickness (1 out of 5 responded that the evaluation item was excellent)
×: Feels not thick at all (0 out of 5 responded that the evaluation items were excellent)

(2) Evaluation of Usability For each cosmetic, a cosmetic use test was conducted by five specialist panels, and the following evaluations were made about the non-stickiness / freshness at the time of application and the non-stickiness / freshness after use. Evaluation was based on point criteria.
◎: Excellent (4 out of 5 responded that the evaluation items were excellent)
○: Slightly superior (2 to 3 out of 5 responded that the evaluation items were excellent)
Δ: Slightly inferior (1 out of 5 responded that the evaluation item was superior)
X: Inferior (out of 5 respondents said that 0 are superior in terms of evaluation items)

The formulation example of this invention is shown below.
Formulation example: Solubilized whitening cosmetic liquid A parts ethanol 10.0
PPG-13
Decyltetradeces-24 0.3
Methyl paraoxybenzoate 0.1
Phenoxyethanol 0.1
Fragrance Mentyl lactate 0.004
B parts glycerin 2.0
PEG / PPG-14 / 7 dimethyl ether 3.0
Dipropylene glycol 1.0
1,3-butylene glycol 5.0
L-serine 0.5
L-alanine 0.5
Ichiyakuso Extract 0.01
Psycho extract 0.05
Dipotassium glycyrrhizinate 0.05
Purified water Residual C parts purified water 50.0
Gellan gum 0.2
4-methoxysalicylic acid potassium salt 1.0
Sodium chloride 1.0
"Production method"
The alcohol phase of A was added to the aqueous phase of B and solubilized to prepare a lotion. Phase C gellan gum was dissolved at 85 ° C., potassium 4-methoxysalicylate was added, cooled to 25 ° C. (room temperature), solidified, crushed, and added to the skin lotion.

Formulation example: Solubilized whitening cosmetic liquid A parts ethanol 10.0
PPG-13
Decyltetradeces-24 0.3
Methyl paraoxybenzoate 0.1
Phenoxyethanol 0.1
Fragrance Trace B parts Glycerin 2.0
PEG / PPG-14 / 7 dimethyl ether 3.0
Dipropylene glycol 1.0
1,3 Butylene glycol 5.0
Beech bud extract 0.5
Asenya extract 0.1
Yukinoshita Extract 0.1
Licorice extract 0.3
Peonies extract 0.5
ONONIS EXTRACT 0.3
Mishima psycho root extract 0.1
Rose extract 0.3
Dipotassium glycyrrhizinate 0.05
Purified water Residual C parts purified water 52.0
Gellan gum 0.2
4-methoxysalicylic acid potassium salt 1.0
Magnesium chloride 0.5
Potassium chloride salt 0.5
"Production method"
The alcohol phase of A was added to the aqueous phase of B and solubilized to prepare a lotion. Gelatin gum of phase C, magnesium chloride salt and potassium chloride salt are dissolved at 85 ° C., 4-methoxysalicylic acid potassium salt is added, cooled to 25 ° C. (room temperature), solidified, pulverized, and lotion Added to.

Formulation Example: Whitening Milk A Parts Dimethicone 1.0
Squalane 1.0
Cetyl ethylhexanoate 2.0
Carboxyvinyl polymer 0.2
Fragrance Trace B parts Glycerin 2.0
Polyoxyethylene hydrogenated castor oil 0.3
Methyl paraoxybenzoate 0.1
Phenoxyethanol 0.1
PEG / PPG-14 / 7 dimethyl ether 3.0
Dipropylene glycol 1.0
1,3-butylene glycol 5.0
Oat extract 0.3
Hinogi extract 0.3
Loquat extract 0.5
Aloe extract 0.3
Ginger extract 0.1
Dipotassium glycyrrhizinate 0.05
Purified water Residual caustic potash appropriate amount C parts purified water 56.0
Gellan gum 0.2
4-methoxysalicylic acid potassium salt 1.0
Potassium chloride 1.0
"Production method"
Add the oil phase of A to the aqueous phase of B and emulsify, then dissolve the gellan gum and potassium chloride of phase C at 85 ° C, add 4-methoxysalicylic acid potassium salt, then cool to 25 ° C (room temperature) The solidified product was pulverized to obtain an emulsion.

Claims (2)

  A cosmetic comprising (a) gellan gum, (b) a neutralizing agent comprising a cation, and (c) 4-methoxysalicylate.   (B) a neutralizing agent comprising a cation dissolves in calcium salt, magnesium salt, sodium salt, potassium salt, or water to dissociate the salt, glycyrrhizic acid dipotassium salt, trimethylglycine, sodium pyrosulfite, citric acid The cosmetic according to claim 1, which is selected from sodium acid and potassium lactate.