JP2008168074A - Apparatus and method for acquiring biological information - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To acquire both an accurate electrocardiogram and an accurate arteriosclerosis index, and also to reduce time and user's efforts for acquiring such biological information. <P>SOLUTION: An electrocardiogram measurement section 204 measures a subject's electrocardiogram. A measurement control section 201 for the upper limb and a measurement control section 202 for the lower limb composing a blood pressure and pulse wave measurement section 200 measure the pulse waves and the subject's blood pressure. An operation control section 10 carries out sequential control of the measurement by the electrocardiogram measurement section 204 and the measurement by the blood pressure and pulse wave measurement section 200. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a biological information acquisition apparatus and a biological information acquisition method.

  Various living body information is used for living body diagnosis. An electrocardiogram measured by an electrocardiograph is one of typical biological information, and is widely used for diagnosis of heart diseases. In an electrocardiogram, a standard 12-lead ECG is typically measured. A standard 12-lead ECG is attached to the subject's chest and six lead ECGs (I, II, III, aVR, avL, aVF) obtained from four ECG electrodes attached to the subject's limbs. 6 electrocardiograms (V1, V2, V3, V4, V5, V6) obtained from the 6 electrocardiographic electrodes. The heart disease of the subject can be diagnosed based on the waveform characteristics of the standard 12-lead electrocardiogram measured from the subject.

  Heart disease is mainly caused by arteriosclerosis. The same can be said for cerebrovascular diseases. With the rapid aging of society, prevention of arteriosclerotic diseases has become an important theme in the medical field, and it is important to detect arteriosclerosis early and treat it appropriately. In recent years, a blood flow disorder of the lower limb arteries called obstructive arteriosclerosis (ASO) is increasing mainly in elderly people. Obstructive arteriosclerosis is one that develops as a result of the progression of arteriosclerosis.

  The arteriosclerosis test includes, for example, a test for blood flow disorder in the lower limb blood vessels and a test for arterial extensibility. The blood pressure pulse wave inspection apparatus used for these examinations can measure biological information such as blood pressure and pulse wave, and derive an index (hereinafter referred to as “arteriosclerosis degree”) that can be used for the examination of arteriosclerosis. Hereinafter, some examples of the degree of arteriosclerosis will be described. In addition, the measuring method of each index is not limited to the one described here, and can be measured by various methods.

  For example, ABI (Ankle Brachial Index) is used for the examination of blood flow disorders in the lower limb blood vessels.

  ABI is a value obtained by dividing the value of the systolic blood pressure of the ankle by the value of the systolic blood pressure of the upper arm, and is sometimes called API or ABPI. As an index similar to ABI, there is an index called TBI (Toe Pressure Index). TBI is a value obtained by dividing the value of the systolic blood pressure of the toe (toe) by the value of the systolic blood pressure of the upper arm, and is sometimes referred to as TPI or TBPI.

  For the examination of arterial extensibility, for example, aortic PWV (Pulse Wave Velocity) (see, for example, Non-Patent Document 1) and baPWV (brachial-ankle Pulse Wave Velocity: upper arm-ankle PWV) (for example, see Non-Patent Document 2) ), CAVI (Cardio-Ankle Vascular Index) (for example, see Non-Patent Document 3) and the like.

  PWV is a pulse wave velocity, and is a value having a velocity unit obtained by dividing the value of the distance between two different points on the blood vessel by the value of the time difference between the pulse waves at the two points. For measuring the pulse wave, for example, various types of pulse wave sensors such as an air conduction type, a photoelectric type, an air bag type, an amorphous type, and a tonometry type are used. Further, the aorta, which is an elastic artery, may be adopted as a target site for PWV measurement, and the PWV measured in the aorta is referred to as the aorta PWV. There are mainly two methods for measuring the aortic PWV.

In one aorta PWV measurement method, for example, the aorta PWV is obtained by the following equation (1).
PWV = (b + c−a) / ΔT (1)
Here, ΔT is the time difference between the pulse wave rising part at the carotid artery part and the pulse wave rising part at the femoral artery part, a is the distance from the suprasternal fossa to the carotid artery part, b is C is the distance from the umbilicus to the femoral artery.

In the other aorta PWV measurement method, for example, the aorta PWV is obtained by the following equation (2).
PWV = D × 1.3 / (ΔT + Tc) (2)
Here, ΔT is a time difference between the pulse wave rising portion in the carotid artery portion and the pulse wave rising portion in the femoral artery portion, and Tc is from the start of the heart II sound (heart sound generated when the aortic valve is closed). It is the time to the notch of the pulse wave in the carotid artery, and D is the linear distance from the right edge of the 2nd intercostal sternum where the heart sound microphone for measuring heart II sound is placed to the femoral artery Yes, 1.3 is an anatomical correction value.

Moreover, baPWV is calculated | required by following Formula (3), for example.
baPWV = (La−Lb) / Tba (3)
Here, Tba is the time difference between the pulse wave rising part at the upper arm and the pulse wave rising part at the ankle, each measured using a cuff, and La is the distance from the aortic valve opening to the ankle. , Lb is the distance from the aortic valve opening to the upper arm.

ここで、Ｐｓは、上腕の収縮期血圧であり、Ｐｄは、上腕の拡張期血圧であり、ρは血液密度であり、ΔＰは、Ｐｓ−Ｐｄである。また、ＰＷＶは、脈波伝播速度であり、例えば次の式（５）により求められる。

ここで、Ｔｂは、心II音の開始から上腕での脈波の切痕部までの時間であり、Ｔｂａは、上腕での脈波立ち上がり部と足首での脈波立ち上がり部との時間差であり、Ｄは、心II音を計測する心音マイクが置かれた胸骨右縁第II肋間から大腿動脈部までの直線距離であり、１．３は解剖学的補正値であり、Ｌ２は、大腿動脈部から膝関節中央部までの直線距離であり、Ｌ３は、膝関節中央部から足首カフ装着中央部までの直線距離である。
増田善昭、金井寛著、「動脈脈波の基礎と臨床」、共立出版、１５〜１９ページ、２０００年 小澤利男、増田善昭著、「脈波速度」、メジカルビュー社、２８〜２９ページ Kohji Shirai, Junji Utino, Kuniaki Ohtsuka, Masanobu Takada, "A Novel Blood Pressure-independent Arterial Wall Stiffness Parameter; Cardio-Ankle Vascular Index (CAVI)", Journal of Atherosclerosis and Thrombosis, Vol.13, No.2 In CAVI measurement, a cuff is attached to the upper arm and ankle (or popliteal area) to measure blood pressure and pulse wave, and a heart sound microphone is attached to the sternum to measure heart sounds. CAVI is obtained by the following equation (4), for example.

Here, Ps is the systolic blood pressure of the upper arm, Pd is the diastolic blood pressure of the upper arm, ρ is the blood density, and ΔP is Ps−Pd. Moreover, PWV is a pulse wave propagation velocity and is calculated | required by following Formula (5), for example.

Here, Tb is the time from the start of the heart II sound to the pulse wave notch on the upper arm, and Tba is the time difference between the pulse wave rising part on the upper arm and the pulse wave rising part on the ankle. , D is the linear distance from the right heel of the sternum to the femoral artery where the heart sound microphone for measuring heart II sound is placed, 1.3 is the anatomical correction value, and L2 is the femoral artery L3 is a linear distance from the knee joint central part to the ankle cuff wearing central part.
Yoshiaki Masuda, Hiroshi Kanai, “Fundamental and Clinical Arterial Pulse Waves”, Kyoritsu Shuppan, 15-19 pages, 2000 Toshio Ozawa, Yoshiaki Masuda, "Pulse wave velocity", Medical View, 28-29 pages Kohji Shirai, Junji Utino, Kuniaki Ohtsuka, Masanobu Takada, "A Novel Blood Pressure-independent Arterial Wall Stiffness Parameter; Cardio-Ankle Vascular Index (CAVI)", Journal of Atherosclerosis and Thrombosis, Vol.13, No.2

  However, in the conventional biometric information acquisition method, in order to obtain both an accurate electrocardiogram and an accurate degree of arteriosclerosis from one subject, an electrocardiograph and a blood pressure pulse wave inspection device, which are separate biometric information acquisition devices, are used. There is a problem that it takes time for the person who performs the inspection. In particular, after the electrocardiogram is measured, the biometric information acquisition device is replaced (that is, the electrocardiograph is removed from the subject and the blood pressure pulse wave examination device is newly attached to the subject), and the degree of arteriosclerosis In the case of performing acquisition, there is a possibility that the subject's resting state may be lost by changing the apparatus, and accurate biological information may not be acquired.

  The present invention has been made in view of the above points, and obtains both an accurate electrocardiogram and an accurate degree of arteriosclerosis, as well as the trouble of a user (for example, a doctor or a laboratory technician) associated with the acquisition of such biological information. It is an object of the present invention to provide a biological information acquisition apparatus and a biological information acquisition method that can reduce the risk.

  The biological information acquisition apparatus of the present invention includes a first measurement unit that measures an electrocardiogram of a subject, a second measurement unit that measures a pulse wave or blood pressure of the subject, the first measurement unit, and the And a control unit that performs sequence control of measurement by the second measurement unit.

  The biometric information acquisition method of the present invention is a biometric information acquisition method of a biometric information acquisition apparatus having first measurement means and second measurement means, wherein the first measurement measures the electrocardiogram of the subject by the first measurement means. A second measuring step for measuring the pulse wave or blood pressure of the subject by the second measuring means, and a control step for sequence-controlling the measurements in the first measuring step and the second measuring step, It was made to have.

  ADVANTAGE OF THE INVENTION According to this invention, the effort of the user accompanying acquisition of an exact electrocardiogram and an exact arteriosclerosis can be reduced.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

  FIG. 1 is a block diagram showing a configuration of a biological information acquisition apparatus according to an embodiment of the present invention. This biological information acquisition apparatus can be applied to various medical devices, but is particularly suitable for use as a blood pressure pulse wave inspection apparatus.

  The biological information acquisition apparatus includes an arithmetic control unit 10, a display unit 70, a recording unit 75, a storage unit 80, a sound generation unit 85, an input / instruction unit 90, an upper limb measurement control unit 201, a lower limb measurement control unit 202, and a heart sound. The measurement unit 203, the electrocardiogram measurement unit 204, and the pulse wave measurement unit 205 are integrated by being housed in a housing of the main body. Two cuffs 21R and 21L are connected to the upper limb measurement control unit 201 via hose 21h, and two cuffs 22R and 22L are connected to the lower limb measurement control unit 202 via hose 22h, respectively. The heart sound measuring unit 203 is connected to the heart sound microphone 23, the electrocardiogram measuring unit 204 is connected to the limb electrocardiographic electrode unit 24 a and the chest electrocardiographic electrode unit 24 b, and the pulse wave measuring unit 205. Are connected to amorphous pulse wave sensors 25a and 25b. The upper limb measurement control unit 201 and the lower limb measurement control unit 202 constitute a blood pressure pulse wave measurement unit 200 of the biological information acquisition apparatus.

  The arithmetic control unit 10 is a general-purpose computer device having a CPU (Central Processing Unit), a ROM (Read Only Memory), a RAM (Random Access Memory), various interfaces, and the like. The arithmetic control unit 10 controls and executes the operation of the entire apparatus described below by executing a control program stored in a built-in memory or an external storage device by the CPU. The control of the entire apparatus by the arithmetic control unit 10 may be realized only by software, or may be realized by a combination of software and hardware.

  The arithmetic control unit 10 also measures an upper limb measurement control unit 201, a lower limb measurement control unit 202, a heart sound measurement unit 203, an electrocardiogram measurement unit 204, and a pulse wave measurement unit 205 (hereinafter referred to as “biological information”). The measurement of the “collection unit” is collectively controlled. In sequence control, the arithmetic control unit 10 can instruct each biological information measurement unit to start measurement. The contents of the sequence control will be described in detail later.

  Further, the arithmetic control unit 10 receives biological information supplied from each biological information measuring unit. The received biometric information is edited or converted into display data when it is necessary to display it on the screen, and then edited or converted into print data when it is necessary to print it on the report paper. After that, the data is output to the recording unit 75. In addition, the arithmetic control unit 10 appropriately stores the biological information in the storage unit 80 and reads the stored biological information.

  In addition, the arithmetic control unit 10 analyzes a waveform obtained from the biological information received from each biological information measuring unit, and based on the analysis result and the numerical value indicated by the received biological information, the degree of arteriosclerosis is calculated. Perform the calculation. Since the degree of arteriosclerosis that can be calculated and the calculation formula thereof have already been described, the description thereof is omitted here. The analysis of the waveform includes detection of feature points in the waveform. The arithmetic control unit 10 also edits or converts the arteriosclerosis degree and the waveform analysis result into display data when necessary to be displayed on the screen, as in the case of biological information, and then displays the report on a report sheet. When printing is necessary, the data is edited or converted into print data and output to the recording unit 75. In addition, the arithmetic control unit 10 appropriately stores the degree of arteriosclerosis and the analysis result in the storage unit 80 and reads out the stored information.

  The arithmetic control unit 10 performs various determination processes on the biological information, the degree of arteriosclerosis, and the waveform analysis result. The arithmetic control unit 10 also edits or converts the result of this determination into display data when it is necessary to display it on the screen, like the degree of arteriosclerosis and biometric information, and displays it on the report sheet. When printing is necessary, the data is edited or converted into print data and output to the recording unit 75. In addition, the arithmetic control unit 10 appropriately stores the determination result in the storage unit 80 and reads out the stored determination result. In addition, the arithmetic control unit 10 outputs a signal instructing the output of the notification sound to the sound generation unit 85 according to the determination result.

  Further, the arithmetic control unit 10 outputs guidance data to the voice generation unit 85 when voice guidance for assisting the user's operation is necessary.

  Further, the arithmetic control unit 10 receives the contents of the input and instruction by the user's operation from the input / instruction part 90, and according to the received contents, each biological information measuring unit, display unit 70, recording unit 75, storage unit 80, voice Settings related to the function of the generation unit 85 are made, and the start and stop of each operation are controlled.

  The display unit 70 has a display screen or the like as a main component, and displays biological information, waveform analysis results, arteriosclerosis degrees, and determination results input as display data from the arithmetic control unit 10 on the screen.

  The recording unit 75 has a paper feed mechanism, a print head, and the like as main components, and prints biometric information, waveform analysis result, arteriosclerosis degree, and determination result input as print data from the arithmetic control unit 10 on a sheet. .

  The storage unit 80 includes a hard disk drive, a writable optical disk drive, a nonvolatile memory, and the like, and can hold information from the arithmetic control unit 10.

  The sound generation unit 85 has a speaker or the like as a main component, and generates a guidance sound or a notification sound in accordance with guidance data or a notification sound output instruction signal input from the arithmetic control unit 10.

  The input / instruction unit 90 includes a keyboard, a mouse, buttons, a touch panel, and the like, and enables input and instructions by user operations. The contents of user input and instructions are notified to the arithmetic control unit 10.

  The pulse wave measuring unit 205 is an amorphous pulse wave measuring means. The pulse wave measurement unit 205 supplies a pulse wave signal of the subject detected by the amorphous pulse wave sensors 25a and 25b appropriately attached to the subject to the arithmetic control unit 10, thereby measuring the pulse wave. I do. The pulse wave measurement may be started when the biological information acquisition apparatus is turned on, or may be started when a pulse wave measurement start instruction is received from the arithmetic control unit 10. The pulse wave measurement by the pulse wave measurement unit 205 is preferably used when the arithmetic control unit 10 obtains the aorta PWV. In this case, one of the amorphous pulse wave sensors 25a and 25b is the carotid part of the subject. The other is attached to the femoral artery of the subject.

  The electrocardiogram measurement unit 204 measures the electrocardiogram by supplying the calculation control unit 10 with the electrocardiogram signals detected by the electrocardiogram electrode unit 24a for the limbs and the electrocardiogram electrode unit 24b for the limbs that are appropriately attached to the subject. . The limb electrocardiogram electrode portion 24a typically includes four electrocardiogram electrodes attached to the right wrist, the left wrist, the right ankle, and the left ankle, respectively. The electrocardiographic electrodes for both ankles are preferably formed so as not to be hindered by the cuffs 22R and 22L attached to the lower limbs. Moreover, the electrocardiogram electrode portion 25b for the chest is typically composed of six electrocardiographic electrodes that are respectively attached to six locations on the chest. The electrocardiogram measurement may be started when the biological information acquisition apparatus is turned on, or may be started when an electrocardiogram measurement start instruction or a pulse wave measurement start instruction is received from the arithmetic control unit 10.

  The heart sound measuring unit 203 measures the heart sound by supplying a heart sound signal detected by the heart sound microphone 23 appropriately attached to the subject to the arithmetic control unit 10. The heart sound measurement may be started when the biological information acquisition apparatus is turned on, or may be started when a pulse wave measurement start instruction is received from the arithmetic control unit 10.

  The blood pressure pulse wave measurement unit 200 is an oscillometric blood pressure pulse wave measurement unit, and has both functions of a blood pressure measurement unit and a pulse wave measurement unit. The upper limb measurement control unit 201 of the blood pressure pulse wave measurement unit 200 includes a pump, an exhaust valve, a CPU, and a memory in addition to the two pressure sensors 211R and 211L. The memory stores a program for controlling blood pressure measurement by the pump, exhaust valve, cuffs 21R and 21L and pulse wave measurement by cuffs 21R and 21L, and setting information related to this control. The measurement control unit 201 for the upper limb executes a program according to the setting information by the CPU. The measurement control unit 201 for the upper limbs uses the pump and the exhaust valve to pressurize the cuffs 21R and 21L by introducing air into the rubber sac 21aR and 21aL of the cuff 21R and cuff 21L through the hose 21h. The cuffs 21R and 21L are decompressed by discharging air from the rubber bags 21aR and 21aL. The cuff 21R indicates a cuff appropriately attached to the upper right arm, and the cuff 21L indicates a cuff appropriately attached to the left upper arm. The target value of the cuff pressure after pressurization is different for pulse wave measurement and blood pressure measurement, and can be set individually.

  The upper limb measurement control unit 201 detects the cuff pressure fluctuations of the cuffs 21R and 21L after the cuff pressurization as pulse wave signals by the pressure sensors 211R and 211L, and the detected pulse wave signal is sent to the arithmetic control unit 10. By supplying, the pulse wave is measured. The measurement of the pulse wave is started when a pulse wave measurement start instruction is received from the calculation control unit 10. Note that only one of the two cuffs 21R and 21L may be used for pulse wave measurement, or both may be used.

  Further, the upper limb measurement control unit 201 detects the cuff pressure with the most remarkable increase in amplitude as the systolic blood pressure while detecting the cuff pressure vibrations of the cuffs 21R and 21L by the pressure sensors 211R and 211L during the cuff pressure reduction. At the same time, the cuff pressure with the most significant vibration reduction is detected as the diastolic blood pressure, and the blood pressure signal is measured by supplying the blood pressure signals respectively indicating the detected systolic blood pressure and diastolic blood pressure to the arithmetic control unit 10. I do. The blood pressure measurement may be started when the biological information acquisition apparatus is turned on, or may be started when a blood pressure measurement start instruction is received from the arithmetic control unit 10. In particular, when a right blood pressure measurement start instruction is received from the calculation control unit 10, blood pressure measurement is performed using only the cuff 21R, and when a left blood pressure measurement start instruction is received from the calculation control unit 10, only the cuff 21L is used. Blood pressure is measured. The systolic blood pressure and the diastolic blood pressure can be detected from the vibrating cuff pressure by the arithmetic control unit 10 instead of the upper limb measurement control unit 201.

  The lower limb measurement control unit 202 of the blood pressure pulse wave measurement unit 200 includes a pump, an exhaust valve, a CPU, and a memory in addition to the two pressure sensors 221R and 221L. The memory stores a program for controlling blood pressure measurement by the pump, exhaust valve, cuffs 22R, 22L and pulse wave measurement by the cuffs 22R, 22L, and setting information related to this control. The lower limb measurement control unit 202 executes a program according to the setting information by the CPU. The lower limb measurement control unit 202 uses the pump and the exhaust valve to pressurize the cuffs 22R and 22L by introducing air into the rubber sac 22aR and 22aL of the cuff 22R and cuff 22L through the hose 22h. The cuffs 22R and 22L are depressurized by discharging air from the rubber pouches 22aR and 22aL. The cuff 22R indicates a cuff that is properly attached to the right ankle, and the cuff 22L indicates a cuff that is appropriately attached to the left ankle. The target value of the cuff pressure after pressurization is different for pulse wave measurement and blood pressure measurement, and can be set individually.

  Further, the measurement control unit 202 for the lower limbs detects a change in the cuff pressure of the cuffs 22R and 22L after the cuff pressurization as a pulse wave signal by the pressure sensors 221R and 221L, and the detected pulse wave signal is sent to the arithmetic control unit 10. By supplying, the pulse wave is measured. The pulse wave measurement is started upon reception of a pulse wave measurement start instruction from the arithmetic control unit 10. Note that only one of the two cuffs 22R and 22L may be used for pulse wave measurement, or both may be used.

  In addition, the measurement control unit 202 for the lower limbs detects the cuff pressure in which the fluctuation is remarkable as the systolic blood pressure while detecting the fluctuation of the cuff pressure of the cuffs 22R and 22L by the pressure sensors 221R and 221L during the cuff pressure reduction. At the same time, the cuff pressure in which the decrease in fluctuation is significant is detected as the diastolic blood pressure, and the blood pressure is measured by supplying the blood pressure signals respectively indicating the detected systolic blood pressure and diastolic blood pressure to the arithmetic control unit 10. . The blood pressure measurement may be started when the biological information acquisition apparatus is turned on, or may be started when a blood pressure measurement start instruction is received from the arithmetic control unit 10. In particular, when a right blood pressure measurement start instruction is received from the calculation control unit 10, blood pressure measurement is performed using only the cuff 22R, and when a left blood pressure measurement start instruction is received from the calculation control unit 10, only the cuff 22L is used. Blood pressure is measured. Note that the systolic blood pressure and the diastolic blood pressure can be detected from the vibrating cuff pressure by the arithmetic control unit 10 instead of the lower limb measurement control unit 202.

  The configuration of the biological information acquisition apparatus according to this embodiment has been described above.

  Next, sequence control performed by the arithmetic control unit 10 for measurement in each biological information measurement unit will be described. FIG. 2 is a flowchart for explaining the sequence control operation by the arithmetic control unit 10. Here, a case where a measurement start instruction is issued from the arithmetic control unit 10 to all the biological information measurement units and a standard 12-lead electrocardiogram test and a blood pressure pulse wave test are performed will be described as an example.

  When the sequence control is started, the arithmetic control unit 10 first outputs an electrocardiogram measurement start instruction to the electrocardiogram measurement unit 204 (step S101). By this instruction, the measurement of the standard 12-lead ECG by the electrocardiogram measurement unit 204 is executed. During the measurement, an electrocardiogram signal is supplied from the electrocardiogram measurement unit 204 to the arithmetic control unit 10. The supplied electrocardiogram signal is output as display data to the display unit 70 and also stored in the storage unit 80. In addition, it is preferable that the electrocardiogram signal preserve | saved here is a thing after the subject's resting state was confirmed by the user.

  Then, the arithmetic control unit 10 detects completion of electrocardiogram measurement (step S102). The time required from the start instruction to completion of electrocardiogram measurement is usually about 10 seconds. Subsequently, the arithmetic control unit 10 outputs a pulse wave measurement start instruction to the upper limb measurement control unit 201, the lower limb measurement control unit 202, the heart sound measurement unit 203, and the electrocardiogram measurement unit 204 (step S103). By this instruction, the electrocardiogram measurement of the electrocardiogram measurement unit 204 (the electrocardiogram measured at this time may be obtained only from the electrocardiogram electrode unit 24a for the limbs), the heart sound measurement of the heart sound measurement unit 203, and the measurement control unit 201 for the upper limbs And the pulse wave measurement of the measurement control part 202 for lower limbs is performed according to the flow of FIG. As described above, after the measurement of the electrocardiogram is completed, it is possible to proceed to the measurement of the pulse wave without changing the apparatus. During the execution of pulse wave measurement, an electrocardiogram signal from the electrocardiogram measurement unit 204, a heart sound signal from the heart sound measurement unit 203, and a pulse wave signal from the measurement control unit 201 for the upper limb and the measurement control unit 202 for the lower limb, respectively, are calculated and controlled. 10 is supplied. The supplied electrocardiogram signal, heart sound signal, and pulse wave signal are output as display data to the display unit 70 and stored in the storage unit 80.

  Then, the arithmetic control unit 10 detects the completion of pulse wave measurement (step S104). The time required from the start instruction to completion of pulse wave measurement is usually about 20 seconds. Subsequently, the arithmetic control unit 10 waits for a certain period (for example, 10 seconds) (step S105), and then outputs a right blood pressure measurement start instruction to the upper limb measurement control unit 201 and the lower limb measurement control unit 202 (step S106). ). By this instruction, the right blood pressure measurement of the upper limb measurement control unit 201 and the lower limb measurement control unit 202 is executed according to the flow of FIG. 4 described later. During the measurement, blood pressure signals are supplied from the upper limb measurement control unit 201 and the lower limb measurement control unit 202 to the arithmetic control unit 10. The supplied blood pressure signal is stored in the storage unit 80.

  Then, the arithmetic control unit 10 detects completion of right blood pressure measurement (step S107). The required time from the start instruction to completion of the right blood pressure measurement is usually about 1 minute. Subsequently, after waiting for a certain period (for example, 5 to 120 seconds) (step S108), the arithmetic control unit 10 outputs a left blood pressure measurement start instruction to the upper limb measurement control unit 201 and the lower limb measurement control unit 202 ( Step S109). By this instruction, the left blood pressure measurement of the upper limb measurement control unit 201 and the lower limb measurement control unit 202 is performed in the same manner as the right blood pressure measurement. During the measurement, blood pressure signals are supplied from the upper limb measurement control unit 201 and the lower limb measurement control unit 202 to the arithmetic control unit 10. The supplied blood pressure signal is stored in the storage unit 80. Further, the arithmetic control unit 10 obtains an average value of the blood pressure from the blood pressure signal obtained by the right blood pressure measurement and the blood pressure signal obtained by the left blood pressure measurement, and outputs this to the display unit 70 as display data. Save in the storage unit 80.

  When the completion of the left blood pressure measurement is detected (step S110), the arithmetic control unit 10 ends the sequence control. The required time from the start instruction to completion of the right blood pressure measurement is usually about 1 minute.

  Thus, in the sequence control exemplified here, the electrocardiogram is measured before the pulse wave and blood pressure are measured, that is, first. Thereby, measurement of an electrocardiogram can be started in a state where the subject is surely resting. Moreover, the resting state of the subject can be recovered by placing an appropriate interval between the measurement of each biological information.

  Incidentally, after the end of the sequence control, the calculation control unit 10 can read out the information stored in the storage unit 80 and calculate the degree of arteriosclerosis such as CAVI or ABI. It is possible to determine whether or not it is normal. In addition, the arithmetic control unit 10 outputs information read from the storage unit 80 to the recording unit 75 so that information related to one subject can be combined into one report and recorded at a time. It is also possible to divide into reports and record them at different times.

  Note that the sequence control described here is an example, and the steps of changing the order of any of the plurality of steps, parallelizing any of the plurality of steps, deleting any of the steps, or performing other control steps. You can add or make changes. Such a change can be realized by a user operation or a program update.

  Although the case where the standard 12-lead electrocardiogram examination and the blood pressure pulse wave examination are performed has been described as an example here, other examinations can be similarly subjected to sequence control. In the biological information acquisition apparatus of the present embodiment, the electrocardiogram measurement unit 204 can perform, for example, an autonomic nerve R-R interval test and an arrhythmia test in addition to the standard 12-lead electrocardiogram test, and a blood pressure pulse wave measurement unit In addition to the blood pressure pulse wave test described above, for example, a footpad waveform test can be performed 200, and the pulse wave measuring unit 205 can perform, for example, an aortic PWV test. Therefore, the sequence control can be set so that any combination of these six tests is executed in any order.

  For example, in the above sequence control, after the standard 12-lead ECG examination, the arithmetic control unit 10 analyzes the waveform of the standard 12-lead ECG. If the result of the analysis shows an arrhythmia, the arrhythmia examination is sent to the ECG measurement unit 204. It may be additionally executed. In addition, when an electrocardiogram abnormality is recognized as a result of the waveform analysis of the standard 12-lead electrocardiogram, the electrocardiogram RR interval test may be additionally executed by the electrocardiogram measurement unit 204.

  Or, after one of the above six tests is completed, other scheduled tests may be canceled or other scheduled ones may be stopped depending on the result of analyzing or determining the measurement results of the tests. The inspection may be additionally performed.

  Alternatively, if it is determined in advance that two or three of the above-described electrocardiogram tests, that is, the standard 12-lead electrocardiogram test, the autonomic nerve RR interval test, and the arrhythmia test, the blood pressure pulse wave test, All electrocardiogram tests may be performed prior to the footpad waveform test and the aortic PWV test (hereinafter, these three tests are collectively referred to as “blood pressure pulse wave test”). As a result, a plurality of electrocardiogram examinations can be performed while keeping the subject's resting state, and the total examination time can be shortened.

  Alternatively, when the standard 12-lead electrocardiogram (or arrhythmia test) is performed prior to the blood pressure pulse wave system test as in the above-described sequence control, as a result of the waveform analysis of the standard 12-lead electrocardiogram (or arrhythmia test), When an electrocardiogram abnormality (or any arrhythmia) is recognized, that fact is displayed on the display unit 70, printed on the recording unit 75, or output as a voice or a notification sound from the voice generation unit 85. Or you may. Thereby, the user can be notified of a decrease in the reliability of the blood pressure pulse wave system test. Further, the autonomic nerve RR interval test may be executed prior to the blood pressure pulse wave system test.

  Alternatively, any one of the blood pressure pulse wave tests may be performed before any one of the electrocardiogram tests. In particular, when the blood pressure pulse wave system test is performed prior to the autonomic nerve R-R interval test or the arrhythmia test, the convenience for the user during the test is improved from the viewpoint of the user's operation and confirmation work. Can do.

  Next, a pulse wave measurement control operation in the blood pressure pulse wave measurement unit 200 will be described with reference to FIG.

  The upper limb measurement control unit 201 and the lower limb measurement control unit 202 first receive a pulse wave measurement start instruction from the arithmetic control unit 10 (step S121). The upper limb measurement control unit 201 pressurizes the cuffs 21R and 21L, and the lower limb measurement control unit 202 pressurizes the cuffs 22R and 22L to, for example, 30 to 50 mmHg (step S122). When the cuff pressurization is completed, the measurement control unit 201 for the upper limb performs measurement of the pulse wave signal of the upper limb over a certain period (for example, 5 seconds), and the measurement control unit 202 for the lower limb also performs the measurement of the pulse wave signal of the lower limb. It is performed over a period (step S123). After the measurement period, the upper limb measurement control unit 201 depressurizes the cuffs 21R and 21L, and the lower limb measurement control unit 202 depressurizes the cuffs 22R and 22L to 0 mmHg (step S124). When the cuff decompression is completed, the upper limb measurement control unit 201 and the lower limb measurement control unit 202 notify the calculation control unit 10 of the completion of the pulse wave measurement (step S125).

  Next, the right blood pressure measurement control operation in the blood pressure pulse wave measurement unit 200 will be described with reference to FIG.

  The upper limb measurement control unit 201 and the lower limb measurement control unit 202 first receive a right blood pressure measurement start instruction from the arithmetic control unit 10 (step S131). The upper limb measurement control unit 201 pressurizes the cuff 21R, and the lower limb measurement control unit 202 pressurizes the cuff 22R to an appropriate value higher than the systolic blood pressure to be measured (step S132). When the cuff pressurization is completed, the upper limb measurement control unit 201 gradually depressurizes the cuff 21R, and the lower limb measurement control unit 202 gradually depressurizes the cuff 22R (step S133). During cuff decompression, the upper limb measurement control unit 201 measures the systolic blood pressure and the diastolic blood pressure of the upper right arm, and the lower limb measurement control unit 202 measures the systolic blood pressure and the diastolic blood pressure of the right ankle (step S134). ). After the blood pressure measurement, when the cuff pressures of the cuffs 21R and 22R reach 0 mmHg, the upper limb measurement control unit 201 and the lower limb measurement control unit 202 notify the arithmetic control unit 10 of the completion of the right blood pressure measurement (step S135).

  Regarding the control operation of the left blood pressure measurement in the blood pressure pulse wave measurement unit 200, the target cuff for pressure increase / decrease is changed from the cuffs 21R and 22R for the right arm and the right ankle to the left upper arm and the left ankle in the description of the right blood pressure measurement control operation. By replacing the cuffs 21L and 22L, it can be realized in the same manner as the right blood pressure measurement.

  As described above, according to the present embodiment, the electrocardiogram measurement and the blood pressure pulse are controlled while controlling the timing of the electrocardiogram measurement by the electrocardiogram measurement unit 204 and the timing of the blood pressure and pulse wave measurement by the blood pressure pulse wave measurement unit 200. Since both of the wave measurements can be performed, it is possible to simplify the operation of the apparatus and the preparation of the apparatus for a user who performs a plurality of examinations such as an electrocardiogram examination and an arteriosclerosis examination. Accurate measurement can be maintained. In particular, the biological information acquisition device and the biological information acquisition method of the present embodiment can perform a plurality of tests continuously or simultaneously without changing the device, thereby losing the subject's resting state. There is a great advantage that a plurality of inspections can be performed in a relatively short time.

  Further, according to the present embodiment, each test result can be recorded in one report as illustrated in FIG. 5 while performing an electrocardiogram test and a blood pressure pulse wave test independently of each other. Further, the arithmetic control unit 10 can make a comprehensive determination on both inspection results, and the determination result can be recorded together with each inspection result in a report. The arithmetic control unit 10 can derive the risk of occurrence of ischemic heart disease included in the determination result based on the expression rate of the ischemic heart disease finding group that can be obtained from the calculated value of CAVI.

  The embodiment of the present invention has been described above. The above description is an illustration of a preferred embodiment of the present invention, and the scope of the present invention is not limited to this. That is, the description of the configuration and operation of the above apparatus is an example, and it is apparent that various modifications and additions to these examples are possible within the scope of the present invention.

The block diagram which shows the structure of the biometric information acquisition apparatus which concerns on one embodiment of this invention. The flowchart for demonstrating an example of the sequence control operation | movement by the arithmetic control part which concerns on one embodiment of this invention The flowchart for demonstrating the pulse-wave measurement control operation by the blood-pressure pulse-wave measuring part which concerns on one embodiment of this invention The flowchart for demonstrating the blood-pressure measurement control operation by the blood-pressure-pulse-wave measuring part which concerns on one embodiment of this invention The figure for demonstrating an example of the report which concerns on one embodiment of this invention

Explanation of symbols

10 Arithmetic Control Unit 21R, 21L, 22R, 22L Cuff 21aR, 21aL, 22aR, 22aL Rubber Sac 21h, 22h Hose 23 Heart Sound Microphone 24a Limb Electrocardiogram Electrode 24b Chest Electrocardiogram Electrode 25a, 25b Amorphous Pulse Wave Sensor 70 Display Unit 75 recording unit 80 storage unit 85 sound generation unit 90 input / instruction unit 200 blood pressure pulse wave measurement unit 201 upper limb measurement control unit 202 lower limb measurement control unit 203 heart sound measurement unit 204 electrocardiogram measurement unit 205 pulse wave measurement unit 211R, 211L 221R, 221L Pressure sensor

Claims (4)

First measuring means for measuring an electrocardiogram of the subject;
Second measuring means for measuring the pulse wave or blood pressure of the subject;
Control means for sequence-controlling measurement by the first measurement means and the second measurement means;
A biological information acquisition apparatus characterized by comprising:   The biological information acquisition apparatus according to claim 1, wherein the first measurement unit measures a standard 12-lead electrocardiogram.   The biological information acquisition according to claim 1, wherein the control unit causes the measurement by the first measurement unit to be performed after the test of the subject is started and before the measurement by the second measurement unit is performed. apparatus. In the biological information acquisition method of the biological information acquisition apparatus having the first measurement means and the second measurement means,
A first measuring step of measuring an electrocardiogram of the subject by the first measuring means;
A second measuring step of measuring the pulse wave or blood pressure of the subject by the second measuring means;
A control step for performing sequence control of the measurement in the first measurement step and the second measurement step;
A biometric information acquisition method comprising:

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