JP2008154702A - Quantitative blood collection tube and fixed amount blood collecting tool - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To easily and securely carry out quantitative blood collection of blood S and quantitative mixing of the blood S and agent R. <P>SOLUTION: A quantitative blood collection tool has a blood collection tube body 21 having an opening in its one end, and a lid member 22 having a blood introducing port and a blood flowing path communicating with the blood introducing port and the blood collection tube body 21; the blood collection tube body 21 has a reduced pressure blood collection chamber 21A sucking the blood S from the blood introducing port 221A by reduced pressure sucking action and an agent holding chamber 21B holding the agent R diluting the blood S, and the lid member 22 has a quantitative collection portion 222 collecting a predetermined amount of the blood S from the blood flowing path and introducing the same into the agent holding chamber 21B. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a blood collection tube for collecting blood.

  For example, when analyzing blood, as a pre-processing step, a step of collecting blood with a vacuum blood collection tube or a syringe, a step of collecting a certain amount of blood in a vacuum blood collection tube using a glass capillary tube or pipette, and a certain amount of blood There is a process in which blood is introduced into a container containing a certain amount of reagent and mixed using a vibration device or the like.

  However, as described above, there are many work steps, and in particular, skill is required for the work of collecting a certain amount of blood using a glass capillary tube or a pipette.

  On the other hand, as shown in Patent Document 1, a blood collection tube that contains blood is introduced into a blood analyzer, a certain amount of blood and reagent are automatically sucked, and introduced into the same container for quantitative mixing. is there.

However, this quantitative mixing is performed exclusively for the blood analyzer, and the mixed liquid cannot be used for other analyzers. Also, quantitative mixing is performed by a mechanism provided integrally in the blood analyzer, and even when the blood is used only for quantitative mixing, it is necessary to use the blood analyzer, which increases the work. .
JP 2002-55069 A

  Therefore, the main object of the present invention is to perform quantitative sampling of blood and quantitative mixing of the blood and a reagent simply and reliably.

  That is, a quantitative blood collection tube according to the present invention includes a blood collection tube main body having an opening at one end, a blood introduction port, and a lid member having a blood flow path communicating the blood introduction port and the blood collection tube main body. The blood collection tube main body has a reduced-pressure blood collection chamber for sucking blood from the blood introduction port by a reduced-pressure suction action, and a reagent storage chamber for containing a reagent mixed with the blood, and the lid member includes the blood channel A predetermined amount of blood is collected and introduced into the reagent storage chamber.

  In such a case, the blood collection tube main body has a reduced-pressure blood collection chamber and a reagent storage chamber, and the lid member has a quantitative collection section for collecting a predetermined amount of blood and introducing it into the reagent storage chamber. Therefore, quantitative collection of blood and quantitative mixing of the blood and reagent can be performed easily and reliably.

  As a specific embodiment of the quantitative collection unit, the quantitative collection unit moves part of the blood channel by moving relative to the blood collection tube main body, and the channel is used as the reagent. It is possible to communicate with the storage room. If this is the case, the blood can be collected and mixed in a very simple operation.

  In addition, a quantitative blood collecting instrument according to the present invention includes the quantitative blood collecting tube and a blood collecting holder into which the quantitative blood collecting tube is inserted.

  According to the present invention configured as described above, the quantitative collection of blood and the quantitative mixing of the blood and the reagent can be performed easily and reliably.

  Hereinafter, a quantitative blood sampling device according to an embodiment of the present invention will be described with reference to the drawings. FIG. 1 is a longitudinal sectional view of the quantitative blood sampling device 1 according to this embodiment. FIG. 2 is a cross-sectional view showing a state in which the quantitative blood collection tube 2 is inserted into the blood collection tube holder 3. FIG. 3 is a cross-sectional view showing the quantitative blood collection tube 2 after blood collection. FIG. 4 is a cross-sectional view showing a state after the quantitative sampling unit 222 has been rotated.

<Device configuration>
As shown in FIG. 1, the quantitative blood collection device 1 according to the present embodiment includes a quantitative blood collection tube 2 and a blood collection tube holder 3 into which the quantitative blood collection tube 2 is inserted when blood is collected.

  First, the blood collection tube holder 3 will be described.

  As shown in FIG. 1, the blood collection tube holder 3 has an opening at one end (rear end portion), a cylindrical holder body 31 into which the quantitative blood collection tube 2 is inserted, and other holder body 31. A blood collection needle 32 that is attached to an end (tip portion) and includes a puncture needle portion 321 extending outward from the holder body 31 and a blood collection needle portion 322 extending inward; The part 322 is provided so as to pierce the lid member 22 of the quantitative blood collection tube 2 during blood collection.

  The holder body 31 is integrally formed of plastic such as polypropylene, polyethylene, polyvinyl chloride, polycarbonate, polystyrene, and the like, and is protruded outward in the radial direction at one end where the opening is formed. A flange portion 33 is formed.

  Next, the quantitative blood collection tube 2 will be described.

  The quantitative blood collection tube 2 is a vacuum blood collection tube provided with a quantitative blood collection device function and a quantitative mixing mechanism. As shown in FIGS. 1 to 4, the quantitative blood collection tube 2 is inserted into the equal blood collection tube holder 3 through the opening at its rear end. A blood collection tube main body 21 having an opening at one end and a lid member 22 that is detachably closed in the opening are provided.

  The blood collection tube main body 21 is a bottomed tube having a circular cross section with one end opened and the other end closed, and the inside thereof is partitioned into a decompression blood collection chamber 21A and a reagent storage chamber 21B by a partition wall 211. . The blood collection tube main body 21 is integrally formed from glass or plastic.

  The decompressed blood collection chamber 21A is decompressed to a predetermined pressure (for example, vacuum). The reagent storage chamber 21B is a chamber for storing a reagent R such as a diluent used for pretreatment of the blood S, and stores the reagent R in advance before blood collection. For example, before decompressing the decompression blood collection chamber 21A, a predetermined reagent is introduced into the reagent housing chamber 21B, and the lid member 22 is plugged to seal the reagent.

  In addition, a thick portion 212 having a flow channel communicating with a blood flow channel provided in the lid member is formed in the opening side portion of the reduced-pressure blood collection chamber 21A. A fixed shaft 224 for attaching a lid member 22 described later is attached to the thick portion 212.

  The lid member 22 closes the opening of the blood collection tube main body 21, and has a blood flow path that communicates the blood introduction port 221 A with the blood introduction port 221 A and the decompression blood collection chamber 21 A of the blood collection tube main body 21. . The lid member 22 includes a lid member main body 221 made of rubber, and a quantitative sampling portion 222 provided on the base end portion (the blood collection tube main body 21 side).

  The lid member main body 221 has a blood introduction port 221A at one end surface and forms a blood flow path therein, and a rubber lid 223 through which the blood collection needle 322 is inserted is attached to the distal end surface. It has been.

  The quantitative sampling part 222 forms a part of the blood flow channel therein, and is pivotally supported by a fixed shaft 224 between the blood collection tube main body 21 and the lid member main body 221. During blood collection, the blood flow path communicates with the reduced-pressure blood collection chamber 21A. As a result, the blood collection needle 322 is pierced through the rubber lid 223, so that the blood S passes through the blood channel and into the reduced pressure collection chamber 21A by the reduced pressure suction action of the reduced pressure collection chamber 21A. Inflow. Thereafter, when the blood sampler rotates the quantitative sampling part 222 by 180 degrees, as shown in FIG. 4, only the flow path formed in the quantitative sampling part 222 is cut off, and the flow path becomes the reagent storage chamber 21B. Communicated with

  In addition, the quantitative collection amount is obtained by changing the cross-sectional area (thickness) of the flow channel formed in the quantitative collection unit 222 and the thickness of the quantitative collection unit 222, that is, the flow rate of the flow channel formed in the quantitative collection unit 222. It can be changed freely by changing the volume. For example, it can be changed to about 1 μL to 20 μL.

  In the present embodiment, since the reagent R is stored in the reagent storage chamber 21B, the blood S that is quantitatively sampled by the quantitative sampling unit 222 by shaking the quantitative blood collection tube 2 (in the cut channel). Blood S) and reagent R are mixed. At this time, the blood S and the reagent R can be mixed quantitatively by adjusting the amount of the reagent R stored in the reagent storage chamber 21B.

  In addition, the quantitative sampling unit 222 and the blood collection tube main body 21 are sealed so that the reagent R and the blood S are not leaked to the outside even when the quantitative sampling unit 222 rotates.

<How to use>
Next, a method of using the quantitative blood sampling device 1 according to this embodiment will be described.

  First, the puncture needle portion 321 of the blood collection tube holder 3 is inserted into the blood collection subject's arm or the like to fix the blood collection tube holder 3. Next, the quantitative blood collection tube 2 is inserted straight into the blood collection tube holder 3. Then, the blood collection tube needle portion 322 of the blood collection tube holder 3 is pierced by the rubber lid 221A of the quantitative blood collection tube 2 (see FIG. 2), and the blood collection needle 32 and the blood channel communicate with each other, thereby reducing the suction pressure. As a result, blood S flows from the blood vessel into the reduced-pressure blood collection chamber 21A (see FIG. 3). As soon as the blood flow of blood collection stops, the quantitative blood collection tube 2 is removed from the blood collection tube holder 3. When blood is continuously collected, the quantitative blood collection tube 2 is replaced while the blood collection tube holder 3 is fixed. When blood collection is completed, the needle 32 of the blood collection tube holder 3 is pulled out and general measures such as disinfection are performed.

  Next, the quantitative collection part 222 of the quantitative blood collection tube 2 taken out from the blood collection tube holder 3 is rotated (see FIG. 4). Thereafter, the quantitative blood collection tube 2 is mixed by inversion. Then, after mixing by inversion, the quantitative blood collection tube 2 is introduced into an analyzer such as a blood cell counter for measurement.

<Effect of this embodiment>
According to the quantitative blood collection device 1 according to the present embodiment configured as described above, blood can be collected by the same procedure as that of a conventionally used vacuum blood collection tube, and a certain amount of blood S is obtained by the quantitative collection unit 222. Can be collected, so that the quantitative blood collection of the blood S can be performed easily and reliably.

  In addition, since the quantitative sampling and quantitative mixing can be performed simultaneously by one operation (one action) of rotating the quantitative sampling unit 222 after blood sampling, quantitative blood sampling and quantitative mixing can be performed very easily.

  In addition, since quantitative blood collection and quantitative mixing can be performed with this instrument 1, some of the quantitative devices, reagent mixing mechanisms, etc. provided inside conventional blood analyzers can be omitted, and as a result In addition, it is possible to reduce the size and cost of the blood analyzer.

<Other modified embodiments>
Needless to say, the present invention is not limited to the above-described embodiment, and various modifications can be made without departing from the spirit of the present invention.

  For example, in the above-described embodiment, the reagent R is stored in the reagent storage chamber 21B before blood collection. However, the reagent R may be stored in the reagent storage chamber 21B after quantitative sampling.

  The quantitative sampling part 222 is rotatably supported by the blood collection tube main body 21 and the lid member main body 221 so as to introduce the quantitatively collected blood S into the reagent storage chamber 21B. In addition, for example, as shown in FIG. 5, sliding movement may be performed with respect to the blood collection tube main body 21 and the lid member main body 221. At this time, as the operation of quantitative collection and quantitative mixing, it is only necessary to push the protrusion 222a.

  Furthermore, in the above embodiment, the blood S is introduced into the quantitative blood collection tube 2 using the blood collection tube holder 3, but the blood collection tube holder 3 may not be used.

  In addition, the blood collection tube main body 21 can be formed of an optically transparent material, and the quantitative blood collection tube 2 can be directly introduced into an analyzer for measuring absorbance or the like.

  In addition, some or all of the above-described embodiments and modified embodiments may be combined as appropriate, and the present invention is not limited to the above-described embodiments, and various modifications can be made without departing from the spirit of the present invention. .

1 is a schematic cross-sectional view of a quantitative blood collection device according to an embodiment of the present invention. Sectional drawing which shows the state which inserted the fixed-quantity blood-collecting tube in the blood-collecting tube holder in the embodiment. Sectional drawing which shows the fixed_quantity | assay blood collection tube after blood collection in the embodiment. Sectional drawing which shows the state after rotating the fixed_quantity | quantitative_collection part in the embodiment. Sectional drawing of the quantitative blood collection tube which concerns on deformation | transformation embodiment.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... Quantitative blood-collecting instrument 2 ... Quantitative blood-collecting blood vessel 21 ... Blood-collecting blood-tube main body 21A ... Pressure-reduced blood-collecting chamber 21B ... Reagent storage chamber 22 ... Cover member 221 ... Cover member main body 221A ..Blood introduction port 222 ・ ・ ・ Quantitative sampling part 3 ・ ・ ・ Blood collection holder

Claims (3)

A blood collection tube body having an opening at one end;
A blood introduction port, and a lid member having a blood flow channel communicating the blood introduction port and the blood collection tube main body,
The blood collection tube main body has a reduced-pressure blood collection chamber for sucking blood from the blood introduction port, and a reagent storage chamber for storing a reagent mixed with the blood,
A quantitative blood collection tube, wherein the lid member has a quantitative collection part for collecting a predetermined amount of blood from the blood flow channel and introducing the blood into the reagent storage chamber.   2. The quantitative sampling part moves relative to the blood collection tube main body, thereby moving a part of the blood flow channel and communicating the flow channel with the reagent storage chamber. Quantitative blood collection tube.   A quantitative blood collection device comprising the quantitative blood collection tube according to claim 1 and a blood collection holder into which the quantitative blood collection tube is inserted.