JP2008142347A - Powder compressed tablet - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a powder compressed tablet capable of preventing a powder raw material from attaching onto the surface of a pestle being a compression member when the powder is compression-molded. <P>SOLUTION: The powder compressed tablet 10 is obtained by compressing and molding the powder raw material and includes a conical part 11 as a shape along a compressing direction. It is preferable that the conical part 11 has a circular conical shape or a pyramidal shape. It is also preferable that the vertex of the conical part 11 is round and the curvature radius R of the vertex in the conical part 11 is 0.2-5 mm in vertical section. Besides, it is preferable that the rising angle of an oblique side in the vertical section of the conical part 11 is 20-60°. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to the shape of a tablet obtained by powder compression molding.

  Conventionally, in a tablet (powder compressed tablet) manufactured by compression molding (powder compression molding) of a powder raw material, a planar shape viewed from the compression direction is generally a circle, a square, a rhombus, or the like. This planar shape is set according to the shape of the ridge (upper heel / lower heel) and the mortar, which are compression members. Further, this planar shape is generally symmetrical with respect to the center in the compression direction. Furthermore, the compression surface is generally flat or curved.

  As described above, tablets produced by compression molding of powder raw materials generally have a simple symmetric shape in many cases. However, by giving the shape characteristics, there are cases where the function resulting from the shape is imparted to the tablet. . For example, it has been proposed to provide a tablet with a function of preventing rolling by forming a beveled portion on one side surface of the tablet so as to make a notch intervention on the outer peripheral side surface (Patent Document 1). In addition, it has been proposed to impart a rolling prevention function to the tablet by inclining the outer peripheral side surface of the tablet (see Patent Document 2).

  Conventionally, when a tablet is produced by powder compression molding, while the compression molding is repeated in the production process, as shown in FIG. 6, the powder raw material (dough) adheres to the surface of the ridge P, which is a compression member, and becomes a foreign substance. It is known that a phenomenon occurs in which chipping occurs on the surface of the tablet T in subsequent molding. This phenomenon is generally called sticking. Sticking contributes to a reduction in manufacturing yield and a reduction in product quality such as a reduction in strength.

  Sticking occurs when the bonding force between the powder raw material and the compression member is larger than the bonding force of the compressed powder compact. In order to avoid this, it is conceivable to compress the powder material to near the true density by applying high pressure, but this would exceed the allowable strength of the compression member and the capacity of the tableting device, making it difficult to design the device. It is. As other methods for preventing sticking, there are a method of internally adding a lubricant to the powder raw material and a method of spraying a small amount of lubricant on the surface of the compression member. However, many of the lubricant components are oil-based components, and are insoluble or hardly soluble in water, which may impair the water solubility of the molded product. The techniques described in Patent Documents 1 and 2 described above provide a function of preventing rolling by giving the characteristics of the shape of the tablet, but nothing has been studied about prevention of sticking.

JP-A-3-123726 Japanese Patent Laid-Open No. 11-21232

  An object of the present invention is to provide a powder compressed tablet capable of eliminating the above-mentioned drawbacks of the prior art.

  The present invention provides a compressed powder tablet obtained by compression molding a powder raw material, and the compressed tablet has a cone-shaped portion as a shape along the compression direction.

  Further, the present invention provides a method for producing a powder compressed tablet, wherein the powder raw material is compression molded using a compression member having a reverse cone shape on the compression surface. It is.

  ADVANTAGE OF THE INVENTION According to this invention, the powder compression tablet of the new design which has a cone-shaped part is provided, and the tablet which is hard to produce sticking at the time of compression molding is obtained stably.

  The present invention will be described below based on preferred embodiments with reference to the drawings. 1 (a) to 1 (c) show an embodiment of the compressed powder tablet of the present invention. Fig.1 (a) is a top view of a tablet, FIG.1 (b) is a front view, FIG.1 (c) is a bottom view. The tablet of this embodiment concerns a solid bath.

  As shown in FIGS. 1A and 1C, the tablet 10 has a regular octagonal outer shape in plan view. Moreover, as shown in FIG.1 (b), the upper region 11, the center region 12, and the bottom region 13 are provided along the height direction. The upper region 11 is a conical portion. Specifically, the base has a regular octagonal pyramid shape, that is, a regular octagonal pyramid shape. The central area 12 is a flat columnar portion. Specifically, it has a columnar body whose bottom surface is a regular octagon, that is, a regular octagonal column. The bottom region 13 has a polyhedral shape in which the bottom surface of a flat regular octagonal column is so-called diamond cut. All of the cut surfaces are triangular and are arranged radially from the center of the bottom region 13 toward the outside.

  As will be described in detail later, the tablet 10 is obtained by compression molding a powder raw material using a compression member having a mold shape corresponding to the shape of the tablet 10. In this embodiment, it shape | molds using the upper collar which has a reverse cone shape. The compression direction at the time of compression molding is the Z direction shown in FIG.

  According to the study of the present inventor, it has been found that the occurrence of sticking depends on the density of the compression molded product. That is, it is considered that there is a density range in which sticking is likely to occur depending on the powder raw material composition during compression molding, and sticking is unlikely to occur even if the density is higher or lower. However, in order to obtain a high-density molded body, high-pressure conditions are required. Therefore, there are restrictions on the apparatus, and if the density is low, even if sticking can be prevented, the density is too low to become a compression molded body. Sometimes.

From this point of view, the most likely condition for sticking when obtaining a compression-molded product having a shape-retaining property that has no practical problem is that a relatively low-density portion of the compression-molded product is exposed on the compression surface. It turns out that. Therefore, it is possible to prevent sticking unless a relatively low density portion is exposed on the surface of the compression molded product. However, when compression molding is performed to the shape shown in FIG. 6, which is a general shape as a compression molded product, the density of the obtained compression molded product becomes almost uniform, so that a relatively low density portion is exposed on the surface. easy.

From this point of view, the present inventor examined various conditions for compression molding, and formed a compression molded product having a cone portion, and compressed the powder raw material along the height direction of the cone portion during the molding. By doing so, it has been found that a portion having a relatively low density can be prevented from being exposed to the surface as much as possible. By forming the tablet into such a shape, density distribution is generated inside the tablet, and even if a relatively low density portion is exposed on the surface of the compression molded product, that portion is the central portion (cone) of the upper and lower compression surfaces. In the shape part, it is estimated that it is possible to keep only one small point). In other words, the region where sticking occurs can be converged to an infinitely small point, and as a result, the occurrence of sticking can be substantially prevented.

FIG. 2 schematically shows the internal density distribution in the longitudinal section of the tablet 10 of FIG. In the figure, the darker the color, the higher the density. As is apparent from the figure, the tablet 10 has a lower density in the width direction and a higher density as it approaches the surface in the width direction. In the figure, the density is shown to change stepwise, but in reality, the density seems to change continuously from the inside toward the surface.

  In FIG. 2, the point to be particularly noted is that the density of the tip portion of the upper region 11 that is a cone-shaped portion, that is, the apex portion of the regular octagonal pyramid, is the most extended portion from the central portion that is the lowest density portion in the tablet 10. It is lower. It is considered that the occurrence of sticking during compression molding can be effectively prevented by the density of the apex portion being the lowest.

  Further, since the density of the tip portion of the upper region 11 is the lowest, an oil agent (for example, a fragrance) as a component necessary for exhibiting the performance of the tablet 10 moves from the high density portion toward the low density portion, It becomes easy to ooze out to the surface of the tablet 10 through the tip portion of the upper region 11. As a result, the peelability between the tablet 10 and the wrinkles is improved, thereby making sticking less likely to occur.

  In actual compression molding, it is not easy to make the tip portion of the cone-shaped portion, that is, the apex portion of the regular octagonal pyramid completely, and roundness is inevitably generated. For this reason, the vertex portion is usually rounded (filleted). However, if the degree of roundness is large, the above-described low density portion is easily exposed on the surface of the tablet 10 and sticking is likely to occur. Therefore, the degree of roundness is preferably as small as possible. Therefore, taking into consideration the balance between prevention of sticking and compression molding conditions, the radius of curvature R (see FIG. 3) of the vertex when the cone-shaped portion is viewed in a longitudinal section through the vertex is 0.2. ˜5 mm, particularly preferably 0.5 to 5 mm.

  The upper region 11 which is a conical portion is more effective from the viewpoint of preventing sticking as the shape thereof is sharper. However, if the upper region 11 is too sharp, it will move away from a practical shape as a tablet. From these viewpoints, the rising angle θ (see FIG. 3) of the hypotenuse S when the conical portion is viewed in a longitudinal section through the apex thereof, that is, the angle θ formed by the hypotenuse S and the horizontal line L is set to 20-60. It is preferable to set the angle to 20 ° to 45 °, particularly 30 ° to 45 °.

  The overall size of the tablet 10 can be appropriately set according to the specific application of the tablet 10. Generally, as shown in FIG. 1B, the height H when viewed from the front can be set to 3 to 80 mm, particularly 4 to 30 mm. The height h1 of the upper region 11 which is a cone-shaped part can be 1-60 mm. The height h2 of the central region 12 can be 1 to 10 mm. Moreover, as shown to Fig.1 (a), the maximum width W by planar view can be 5-70 mm, especially 10-30 mm.

  The lower region 13 shown in FIG. 1B has a polyhedral shape that narrows toward the bottom surface as described above, but may be a flat columnar portion that is the same as the middle region 12. The height h3 of the lower region 13 can be 0.1-5 mm, in particular 0.5-3 mm.

  Further, the shape of the bottom surface portion of the tablet 10 is not limited to a flat surface as shown in FIGS. 1B and 1C, and is a convex curved surface curved outward or a concave curved surface curved inward. Also good.

  The composition of the powder used as the raw material of the tablet 10 can be appropriately set according to the specific application of the tablet 10. When the use is a solid bath agent, the powder raw material preferably contains a carbonate, an organic acid, and a polymer binder. As the carbonate, sodium carbonate, sodium hydrogen carbonate, magnesium carbonate, potassium carbonate and the like are used. As the organic acid, it is preferable to use a water-soluble and solid acid such as succinic acid, fumaric acid, malic acid, adipic acid, tartaric acid, benzoic acid, citric acid, pyrrolidone carboxylic acid and salicylic acid. Polyethylene glycol (molecular weight 1000 to 20000) is preferably used as the polymer binder.

  Next, the preferable manufacturing method of the tablet 10 of this embodiment is demonstrated, referring FIG. The tablet 10 is manufactured using the tableting device 20. The tableting device 20 may be a single-shot tableting machine, a rotary tableting machine, a laminated tableting machine, a rotary cored tableting machine, or the like. The tableting device 20 has a set of molding dies provided with rod-like upper and lower punches 21 and 22 and a cylindrical mortar 23. The upper eyelid 21 has a reverse cone-shaped molding surface 21 a that is complementary to the upper region 11 of the tablet 10. The lower punch 22 has a molding surface 22 a that is complementary to the bottom region 13 of the tablet 10. The mortar hole of the mortar 23 has a complementary shape with the central region 12 of the tablet 10. The upper punch 21, the lower punch 22 and the mortar 23 constituting the mold are made of conventional materials such as metals and ceramics conventionally used for this type of tableting device.

  The upper punch 21 and the lower punch 22 have the same cross-sectional shape as the cross-sectional shape of the mortar hole of the mortar 23, and can penetrate into the mortar hole. The upper collar 21 and the lower collar 22 are installed at positions where their axial centers coincide with the center of the acetabulum. The upper rod 21 and the lower rod 22 are slidable in the vertical direction along the axis. As a result, the upper punch 21 and the lower punch 22 can be inserted into the mortar of the mortar 23. The sliding of the upper rod 21 and the lower rod 22 can be performed by a known means such as a hydraulic device or a lifting cam (not shown).

  The manufacturing method of the tablet 10 using the tableting device 20 having the above configuration will be described. First, as shown in FIG. 4A, the tip of the lower punch 22 is moved into the mortar of the mortar 23 by a lifting mechanism (not shown). Inserted into. Thereby, the powder filling portion 24 is formed by the mortar hole and the molding surface 22 a of the lower jaw 22. On the other hand, the upper collar 21 is raised and retracted by a lifting mechanism (not shown).

  Next, as shown in FIG.4 (b), the powder raw material F is supplied from a powder supply apparatus (not shown), and is filled in a powder filling part. Subsequently, the lower eyelid 22 is slightly lifted by a lifting mechanism (not shown). A part of the powder raw material filled in the powder filling portion overflows from the powder filling portion due to the rise of the lower punch 22. The overflowing powder material is removed by a scraping plate (not shown). As a result, the powder filling portion is fully filled with the powder raw material.

  Next, as shown in FIG. 4 (c), the lower hook 22 starts to descend while keeping the position of the lower hook 22, and the tip of the upper hook 21 is inserted into the powder filling portion. In a state where the tips of both sides are inserted into the powder filling part, the powder raw materials filled in the powder filling part are slid in the directions close to each other so that the powder raw material filled in the powder filling part It is compressed between the upper end surfaces of the flanges 22.

The powder raw material is preferably compressed in two stages: pre-compression performed at a relatively low pressure and main compression performed at a pressure higher than the pre-compression. At that time, the pre-compression is sufficient if the air contained in the powder raw material can be sufficiently removed. That is, there is no need for further compression, for example, compression in which the binder in the raw material causes deformation for bonding, preventing raw material adhesion in the pre-compression, and performing the compression necessary for the main compression at once. Is preferred. As a result, the occurrence of sticking can be more effectively prevented.

  The compression force (tablet pressure) at the time of tableting can be appropriately set according to the physical properties of the tablet such as tablet thickness, diameter, tablet hardness, disintegration time, etc. within the allowable pressure range. In consideration of the physical properties of the tablet such as porosity, moldability, hardness, and disintegration after preventing the occurrence of sticking, the tableting pressure is preferably 30 to 250 MPa, particularly 50 to 200 MPa. The tableting force is a value obtained by converting the pressure per unit area of the punch (per unit cross-sectional area in the axial direction of the powder filling space of the punch) from the pressure of the tableting machine. Tableting is preferably performed at a temperature that does not adversely affect the powder raw material, for example, normal temperature (20 to 30 ° C.).

  The compression by the both sides 21 and 22 is performed along the height direction of the upper region 11 which is a conical portion in the target tablet 10. This makes it possible to provide a density distribution as shown in FIG. The reason why such a density distribution occurs is considered to be that a flow and force that are pushed outward are applied to the powder raw material by being compressed with an inverted cone-shaped mold (upper collar).

  When a target tablet is obtained by applying a compressive force to the powder raw material for a predetermined time, the upper punch 21 is lifted and taken out from the powder filling portion and retracted upward. At this time, adhesion of the powder raw material to the molding surface 21a of the upper collar 21 is not observed. Simultaneously with or slightly after raising the upper eyelid 21, the lower eyelid 22 is also raised. The lower punch 21 rises to a position where its upper end surface is flush with the upper surface of the mortar 23. Thereby, the tablet 10 obtained by compression molding is taken out. Thereafter, the lower punch 22 descends and returns to the position where the powder filling portion is formed together with the mortar 23.

  As mentioned above, although this invention was demonstrated based on the preferable embodiment, this invention is not restrict | limited to the said embodiment. For example, the tablet 10 of the above embodiment has one conical portion, but instead, it may have a shape having two conical portions facing in opposite directions.

  Moreover, although the upper area | region 11 which is a cone-shaped part in the tablet 10 of the said embodiment was a regular octagonal pyramid shape, it replaced with this and the upper area 11 has comprised the polygonal pyramid shape other than an octagon. Also good. In this case, the bottom surface of the pyramid may be a regular polygon or may not be a regular polygon. Furthermore, the upper region 11 may be conical.

  Moreover, you may make the bottom part area | region 13 shown in FIG. 1 into a gentle dome shape as a shape of a tablet. Or you may employ | adopt the shape which formed only the column-shaped center area | region and the cone-shaped upper area | region, without forming the bottom part area | region 13 shown in FIG.

  Moreover, although the said embodiment is an example which applied the tablet which concerns on this invention to a solid bath agent, the tablet of this invention can be applied without a restriction | limiting in particular for another use. For example, it can be applied to uncoated tablets, chewable tablets, multilayer tablets, dry-coated tablets, film tablets using these as core tablets, sugar-coated tablets, mouth fresheners, tablet-type detergents, and the like.

  Hereinafter, the present invention will be described in more detail with reference to examples. However, the scope of the present invention is not limited to such examples. Unless otherwise specified, “%” means “% by weight”.

[Example 1]
According to the method shown in FIG. 4, a solid bathing agent having the shape shown in FIG. 1 was produced. As for the dimensions of the solid bath agent, the maximum width W in the plan view is 16.5 mm, the height H in the front view is 9.5 mm, the height h1 in the upper region is 4.5 mm, and the height h2 in the central region is 3 mm. It was. The composition of the powder raw material was as follows.
・ Sodium bicarbonate 20%
・ 20% sodium carbonate
・ Fumaric acid 40%
-Polyethylene glycol (molecular weight 6000), fragrance and other ingredients 20%

  When the above powder raw material was used and tableting was performed at a tableting pressure of 51 MPa, no sticking was observed even after 10000 times of tableting.

[Comparative Example 1]
A solid bath with the shape shown in FIG. 5 was produced. The dimensions of the solid bathing agent were D = 15 mm, H = 8 mm, h1 = 2 mm, and h2 = 3 mm in FIG. The composition of the powder raw material was the same as in Example 1. When this powder raw material was used for tableting at a tableting pressure of 50 MPa, the occurrence of sticking was observed after 200 tablets.

It is the top view which shows the tablet of this invention, a front view, and a bottom view. It is a figure showing the density distribution in the inside of a tablet shown in FIG. It is a figure which shows the curvature radius of the top part in the tablet shown in FIG. 1, and the standup angle of a hypotenuse. It is process drawing which shows the manufacturing method of the tablet shown in FIG. It is a figure which shows the shape and dimension of the solid bath agent manufactured in the comparative example 1. It is a schematic diagram which shows the state in which sticking generate | occur | produces at the time of the compression molding of a powder raw material.

Explanation of symbols

10 Tablets 11 Upper region 12 Central region 13 Bottom region

Claims (5)

  A powder compressed tablet obtained by compression molding a powder raw material, wherein the tablet has a cone-shaped portion as a shape along a compression direction.   2. The compressed powder tablet according to claim 1, wherein the conical portion has a conical shape or a pyramid shape.   The powder compressed tablet according to claim 1 or 2, wherein the apex of the cone-shaped portion is rounded, and the radius of curvature R of the apex in the longitudinal sectional view of the cone-shaped portion is 0.2 to 5 mm.   The powder compressed tablet according to any one of claims 1 to 3, wherein a rising angle of a hypotenuse in a longitudinal sectional view of the conical portion is 20 to 60 degrees.   A method for producing a powder compressed tablet, wherein the powder raw material is compression-molded using a compression member having a compression surface having an inverted cone shape.