JP2008113728A - Vital reaction recorder and vital reaction registration method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To solve the problem that a mechanocardiogram recorder is not useful for the diagnosis of the circulatory organ system because the mechanocardiogram recorder is large and very costly despite the recognition of a high medical value of the mechanocardiogram while the measuring performances are so poor as to require at least two medical specialists and to make measurement only possible in a specific environment such as that in a sound proof chamber but no data effective for a living body truly requiring the diagnosis using the mechanocardiogram can be acquired. <P>SOLUTION: The small and inexpensive vital reaction recorder of a note type personal computer size herein provided fully operates a two-dimensional pressure sensor which can measure changes in pressure simultaneously at a plurality of locations that allow the living body to approach pertaining to one measuring beat, an electronic device of a personal computer level and a memory to measure an apex beat diagram or the like and can store and utilize the hourly transition of biomedical information to enable the display of the biomedical information as a digital image. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention is first made on the assumption that the living body to be measured is a human being, but can also be applied to cases where the living body to be measured is other than a human being.

  However, a particularly important purpose is utilization for human beings, and in the following description, the case where the living body to be measured is a human will be described as an example.

  INDUSTRIAL APPLICABILITY The present invention can be used for diagnosing the state of the heart by measuring the movement of the living heart and large blood vessels themselves and the change in blood flow sent from the heart into the living body as pressure changes in the chest and abdomen. More specifically, the biological reaction recording apparatus and the biological reaction recording method, and more specifically, at least one of a cardiac apex pulsation, a right ventricular pulsation, and a left atrial pulsation without using a special measurement room such as a soundproof room. Pressure in the chest or abdomen as at least one of heartbeat ascending or ascending aorta pulsation, pulmonary artery (including at least one of pulmonary trunk and central pulmonary artery), abdominal aorta pulsation or liver pulsation The present invention relates to a biological reaction recording apparatus and a biological reaction recording method that can be detected and recorded as a change measurement result, can be miniaturized, and can be realized as an inexpensive apparatus.

  In recent years, not only medicine itself but also medical development accompanying the progress of engineering is remarkable.

  This tendency is the same in the field of cardiovascular medicine.

  For example, the blood pressure measuring device has been remarkably advanced and popularized, and has been widely used by the general public regardless of the involvement of medical professionals.

  In hospitals and other places where medical professionals are deeply involved, a lot of data such as ankle blood pressure, upper limb blood pressure, carotid, femoral, popliteal, and limb peripheral arterial waves are collected. It is stored in a storage device and used for diagnosis. These circulatory system measurements are performed in such a way that the body to be measured enters a special measurement room such as a soundproof room, except for the chest, abdomen, and neck (jugular vein) of the human body, and at least two medical professionals are attached. A lot of data is taken without imposing a burden.

  However, the situation is very different for the chest, abdomen and neck (jugular vein).

  Regarding visual inspection and palpation in circulatory system examination, jugular vein pulsation, carotid artery pulsation and apex pulsation are particularly important.

  Of these, carotid pulsation has already been measured and recorded as a carotid wave by a measuring instrument and can be used for diagnosis. However, with regard to apex pulsation, there is still no practical measuring device as will be described later.

  For a long time, carotid waves and apex rhythms have been measured and recorded by a cardiac recording device (Non-patent document 1: Actual electrocardiogram / cardiographic examination, see page 211) in a special measurement room such as a soundproof room. . As can be seen from the description of Non-Patent Document 1 described later, the recording of the conventional heart machine diagram is made by having the subject to be measured enter a special measurement room such as a soundproof room, and lying on the bed in a special environment. Using the set heartbeat diagram recording device, data is measured as a heartbeat diagram by at least two doctors or doctors and technicians and recorded on a paper medium.

  FIG. 20 is a photograph of the main body recording device set outside the soundproof room described in the page 212 of Non-Patent Document 1, and FIG. 21 is a diagram of various transducers described on page 212 of Non-Patent Document 1. It is a photograph of an example.

  The non-patent document 1 describes the MIC8800T type manufactured by F Company in the heartbeat diagram recording apparatus shown in FIG. 20, but is provided with a moving carriage below, with a width of about 60 cm and a height of about 60 cm. The large size is about 180 cm and the depth is about 80 cm. Although it has a caster for movement, it is a heavy device that is difficult to move alone. The window that is visible on the right side of the main body recording device main body is a window that looks into the soundproof room containing the living body to be measured.

  This device is not only large, but also very expensive.

  It is described in Non-Patent Document 1 that the transducer shown in FIG. 21C can record the apex rhythm and the phonocardiogram at the same time.

  22 is a perspective view of the biological sound detection device described in FIG. 1 of Japanese Patent Laid-Open No. 2000-60845 (hereinafter also referred to as Patent Document 1), and FIG. 23 is the biological sound detection device of FIG. FIG. 24 is a cross-sectional view of a portion indicated by reference numeral 40 in FIG. 23 is referred to as a microphone, and the whole component in FIGS. 22 and 23 is referred to as a biological sound detection device).

  The living body sound detection apparatus shown in FIGS. 22 and 23 records a heart sound diagram by detecting a heart sound with a microphone mounted on the skin, and from other than the living body to be detected so that the heart sound can be detected as accurately and as sensitively as possible. Various devices have been devised in order to suppress the influence of environmental noises such as generated speech, footsteps, and door opening / closing sounds.

  As a device for suppressing the influence of environmental noise, in FIG. 23, an air chamber 66 (64 in FIG. 23 is considered to be a mistake in 66) and the vibration absorber 64 between the housing 22 and the microphone 40. 28, vibration absorbing sheet 46, weight 60, etc., to suppress the influence of environmental noise. Further, in order to enhance the body sound detection effect, a tapered sound collection hole having a diameter decreasing from the skin side of the living body to the microphone side is provided between the microphone 40 and the body skin 11. It can be said that these represent the difficulty of measuring heart sounds.

  The heart sound detection device described in Patent Document 1 shown in FIG. 22 and FIG. 23 is different in purpose and function from the pressure sensor for pulsatogram measurement of the present invention, but is shown in FIG. 21C. In reference to the fact that the transducer can record the apex rhythm and the phonocardiogram at the same time as described in Non-Patent Document 1, and to refer to the fact that a lot of ingenuity is required in the measurement of the heart sound, the above cited references It is.

  24 and 25 are perspective views of a sensor actually used in the heartbeat diagram recording apparatus MIC8800T type of FIG. 20, FIG. 24 is a transducer for measuring a pulsation diagram, and FIG. 25 is a transducer for measuring a heart sound diagram. It is.

  In FIGS. 24 and 25, reference numeral 110 is a pulsatile diagram measurement transducer, 120 is a heart sound diagram measurement transducer, 111 is a pressure transmission unit, 121 is a heart sound measurement unit, 112 is a case outer peripheral frame, 113 and 123 Is the side of the case, and 114 and 124 are lead wires. The case side surface 123 and the outer surface of the heart sound measuring unit 121 are formed of an integral metal.

  In the pulsation diagram measurement transducer 110, the pressure transmission part 111 is made of a hard material such as ceramic, and is separated from the case outer peripheral frame 112, so that it moves slightly when pushed downward from the upper side of the figure. It has become. When the transducer 110 is applied to the skin of the pulsation measurement site of the living body to be measured, the pulsation is transmitted as a pressure change through the pressure transmission unit 111 to a pressure sensor (not shown) connected thereto and converted into an electrical signal. Then, the signal is input from the lead wire 114 to a cardiac device recording device (not shown), and the pulsation is measured.

  The heart sound is detected by attaching the transducer 120 for measuring a heart sound diagram to the skin of the heart sound measurement portion of the living body to be measured, and the heart sound is input from the lead wire 124 to a heartbeat diagram recording apparatus (not shown) to measure the heart sound.

  The outer peripheral frame 112 of the transducer 110 has a circular outer periphery with a diameter of 30 mm, and the pressure transmitting portion 111 is disposed inside the outer peripheral frame 112 and has a circular outer periphery with a diameter of 20 mm. The weight of the transducer 110 measured with a minimum is 19 g.

  A case outer peripheral frame 122 of the transducer 120 has a circular outer periphery, a diameter of 25 mm, and the weight of the transducer 120 measured with a minimum influence of the lead wire is 34 g.

  Such a transducer 110 and transducer 120 are attached to a measurement site of a living body to be measured, and each lead wire is connected to the heartbeat diagram recording apparatus main body shown in FIG. 20 to measure pulsation and heart sound. And create a phonocardiogram.

  FIG. 26 is a diagram of the cardiac rhythm measurement described in the figure on page 222 of Non-Patent Document 1. In order to measure the cardiac rhythm, it enters the soundproof room and is placed on the left side on the bed, and a measurement microphone is attached to the chest. It is the photograph of the to-be-measured living body.

  This is because, in the photograph, the microphone lead wire is suspended from above, and otherwise environmental noise may be mixed.

  In the vicinity of the cardiac diagram recording apparatus shown in FIG. 20, the measurer looks at the inside of the soundproof room from the window visible on the right side of the cardiac chart recording apparatus, and uses a microphone or the like other than the measurement terminal to identify the living body to be measured. You must measure the heartbeat diagram while communicating such as "hold your breath" or "exhale".

  FIG. 27 is a heart diagram obtained as a result of the measurement. Reference numeral 101 is an apex rhythm diagram, 102 is a heart sound diagram (treble), 103 is a heart sound diagram (medium sound), 104 is a heart sound diagram (bass), and 105 is an electrocardiogram.

  In FIG. 27, since the living body to be measured is a young healthy person, three sounds appear in the phonocardiogram 104. This data can be said to be healthy person data. There are four sounds in the phonocardiogram 104, which are usually not heard by auscultation.

  It has been recognized among medical staff that the cardiac mechanism itself is necessary, but as described in Non-Patent Document 1, the measurement of apical rhythm is very advanced and requires specialists. As such, it requires a high degree of diagnostic ability and has many problems.

  For example, it can be obtained by solving many problems such as the problem that the waveform changes if the measurement microphone is not properly placed on the chest, and the waveform changes depending on the time constant setting in the data processing of the detected pressure sensor. It is not useful for diagnosis unless the apex rhythm diagram is given.

  There are many problems with such measurements. For example, there are the following problems.

  First, it is necessary to put the patient in a special measurement room such as a soundproof room, so that the patient is limited to those who can withstand the measurement in such an environment, and second, the measurement Because of the large size of the vessel and the need for more than one measurer, and thirdly, the measurement is performed in a restricted room such as a closed room, so that the measurement is performed in an unusual condition of the patient. Is unnecessarily tense, and fourthly, the device is very expensive. For this reason, there is a great limitation on the selection of the living body to be measured, it places a heavy burden on the living body to be measured, it is difficult to apply to severely ill patients who really want to make a diagnosis, the device is extremely expensive, and the medical care involved in the measurement Mostly used because the cost of collecting data such as the necessity of multiple experts is high, the utility value of the data itself is low, such as the inability to electronically record data and the inability to collect data for critically ill patients The current situation is not.

  As mentioned above, a practical recording device has been developed that does not require a special environment such as a soundproof room, except for the chest, abdomen, and neck (jugular vein). A lot of data is taken and used.

  However, with regard to the chest, abdomen, and neck (jugular vein), as described above, a substantially large heart-cardiogram recording device is made for research purposes. And at least two medical professionals measure the psychocardiogram. And, it is thought that medical value is high, and if it is used correctly, it will lead to a big progress in medicine. Therefore, it is considered that the utility value is low, so the needs are not considered to be many in reality, and medical machine manufacturers cannot spend a lot of money on the development of cardiac device recording device It is believed that.

  At the present time, a heart-recording device that can be measured at the bedside is considered impossible, and of course has not yet been developed. In addition, the conventional cardiac device recording device cannot grasp the temporal changes of the cardiac device, and only captures the averaged movement of the heart and measures the spread of the movement of the heart itself. Detailed information that can support the findings is not available.

  This situation can also be understood by the low score for calculating the value of medical care. In other words, in the case of diagnosis using a conventional cardiac device recording device to record the cardiac device, only a relatively low score is recognized compared to the case of using other devices, The actual situation is that the company will be in the red when considering labor costs and equipment costs. However, in this regard, as described above, the recording of the apex rhythm using the conventional cardiogram recording device is only data taken under very limited restrictions, and from many experts. It can be said that it is unavoidable to give up considering the current situation that it is considered that a cardiac device recording device cannot be used for a patient who really wants to make a diagnosis.

  It is always said that physical findings are important in medicine.

  Exams for obtaining physical findings, in particular diagnostic imaging tests, have made great strides, and depending on the medical field, it has become possible to present features of a disease state objectively, clearly and objectively. For this reason, there is a lot of reliance and expectation on these device diagnoses, and there is a possibility that the examination findings that are difficult to display objectively, such as auscultation and auscultation, cannot be taken care of.

  Relying on costly equipment inspections as easily as the current situation without conducting appropriate examinations for accurate medical examinations has led to an increase in medical costs. The importance of physical findings is screamed from this viewpoint and the need to further enhance communication between doctors and patients.

  On the other hand, the physical findings are subjective and lack objectivity. In education, it is important to teach the correct way of diagnosis, but there is a big problem in the current situation that the method has been carried out by each person.

  As explained above, regarding the new development of cardiac recording devices, medical device manufacturers are not very motivated to develop, but from the viewpoint of a doctor who truly understands this field, In view of the current situation where no objective evaluation of palpation and auscultation is performed, if a small and inexpensive cardiogram recording device that can be measured at the bedside and can be evaluated objectively can be realized, it can be used for cardiovascular medical care. Think of it as a great gospel.

Published by Japan Society for Clinical Hygiene and Examination: “Actual electrocardiogram and electrocardiographic examination” (published on November 1, 1996, 2nd edition), pages 212 and 222 Japanese Patent Laid-Open No. 2000-60845

  As described above, in the conventional cardiac device recording apparatus, not only the measurement cost is high, but also effective data cannot be obtained for a living body that really requires diagnosis using the cardiac device, and the movement of the heart itself is expanded. Information on heart movements such as the inability to grasp detailed movements as described above is insufficient, and it was thought that the cardiac device recording device was not useful for diagnosis of the circulatory system.

  However, an objective evaluation that can be measured at the normal bedside of the living body, can also grasp changes in cardiac function over time, and can support palpation findings like the distribution of movement of the heart itself. If a small and inexpensive cardiogram recording apparatus capable of obtaining sufficient information necessary for diagnosis is realized, a significant medical advancement concerning at least the chest and abdomen can be brought about.

  The present invention has been made in view of such a current situation, and one of the objects of the present invention is that of cardiac apex, right ventricular beat, and left atrial beat in circulatory system examination. Heart beat or ascending aorta beat or pulmonary artery (including at least one of pulmonary trunk and central pulmonary artery) beat or abdominal aorta beat or liver beat as at least one kind of beat Even at the bedside, measurement and recording can be done by detecting pressure changes with pressure sensors so that patient data can be evaluated on the spot, feedback can be given to the patient, and educational From a medical point of view, a biological reaction recording method and a biological reaction recording apparatus that can greatly improve clinical medical education for medical students and trainees are provided at low cost.

  A remarkable feature of the technical idea of the present invention made to solve the above problems is that a pressure sensor is used for a chest, abdomen, etc. of a living body to be measured using a small, light and inexpensive device that can be easily carried by one person. The pressure change at a plurality of locations in the vicinity of the measurement location is recorded.

  Examples of the present invention will be specifically described below.

  A first invention as an example of the present invention made to solve the problem (hereinafter, also referred to as Invention 1) includes at least one of a cardiac apex beat, a right ventricular beat, and a left atrial beat. As a measurement result of pressure change, at least one of pulsation, ascending aorta pulsation, pulmonary artery (including at least one of pulmonary artery trunk and central pulmonary artery), abdominal aorta pulsation or liver pulsation A novel biological reaction recording device capable of detecting and recording, wherein the biological reaction recording device is measured as a pressure sensor capable of measuring the movement of at least one pulsation detection site as a pressure change. Data processing means such as an arithmetic processing unit capable of detecting biological reaction information (hereinafter also referred to as biological information) based on amplification means such as signals and measured data, and a small amount of measured data Data such as biological information detected using at least the main part and data processing means, information processed using the data processing means, or information in the middle of processing (hereinafter referred to as biological information detected using the data processing means or The pressure sensor has storage means and display means capable of storing at least one of data processed using the data processing means or data such as information in the middle of processing is also called detection data) Can measure the pressure at a plurality of locations adjacent to the living body with respect to one pulsation to be measured, and the storage means stores at least one of the measurement data at the plurality of locations and at least one of the detection data. It is a biological reaction recording device characterized by being able to perform.

  A second invention (hereinafter referred to as invention 2) as an example of the present invention developed from the invention 1 is the biological reaction recording apparatus according to the invention 1, wherein the biological reaction recording apparatus is the same subject to be measured. A biological reaction recording apparatus capable of storing the detection data measured at a plurality of different times (hereinafter also referred to as a change with time of detection data).

  A third invention (hereinafter referred to as invention 3) as an example of the present invention developed by developing the invention 1 or 2 is the biological reaction recording apparatus according to the invention 1 or 2, wherein the biological reaction recording apparatus is an electrocardiogram. A biological reaction recording apparatus having a measurement sensor and a phonocardiogram measurement sensor.

  A fourth invention (hereinafter referred to as invention 4) as an example of the present invention developed by developing the inventions 1 to 3 is the biological reaction recording apparatus according to any one of the inventions 1 to 3, wherein the living body A biological reaction characterized in that the reaction recording device can input at least one of electrocardiogram and electrocardiogram data of a living body to be measured from the outside of the biological reaction recording device and can be synchronized with at least one of the data It is a recording device.

  A fifth invention (hereinafter referred to as invention 5) as an example of the present invention developed by developing the inventions 1 to 4 is the biological reaction recording apparatus according to any one of the inventions 1 to 4, wherein the living body The reaction recording apparatus has an extreme value selection means for selecting an extreme value of processed data such as the measurement data and the detection data, and a means for selecting peripheral data of the extreme value as extreme value peripheral data. This is a biological reaction recording device.

  The sixth invention (hereinafter referred to as invention 6) as an example of the present invention developed by developing the inventions 1 to 5 is the biological reaction recording apparatus according to any one of the inventions 1 to 5, wherein the display The biological reaction recording apparatus is characterized in that diagnostic information relating to the health condition of the living body can be displayed on the means.

  A seventh invention (hereinafter referred to as invention 7) as an example of the present invention developed by developing the inventions 1 to 6 is the biological reaction recording apparatus according to any one of the inventions 1 to 6, wherein the display It is a biological reaction recording device characterized in that the diagnostic information can be displayed with a health level such as health, caution 1, caution 2, danger, etc. attached to the means.

  An eighth invention (hereinafter referred to as invention 8) as an example of the present invention developed by developing the invention 6 or 7 is a diagnosis relating to the health condition of the living body in the biological reaction recording apparatus according to the invention 6 or 7. The information includes an electrocardiogram, a heart sound diagram, and a pulsation diagram, and further includes at least one of primary differential data obtained by differentiating a time-beat waveform with respect to time and secondary differential data obtained by differentiating the primary differential data with respect to time. This is a biological reaction recording apparatus.

  The ninth invention (hereinafter referred to as invention 9) as an example of the present invention developed from the inventions 1 to 8 is the biological reaction recording apparatus according to any one of the inventions 1 to 8, wherein the display The means can display an electrocardiogram, a heart sound chart, and a pulsation diagram of the living body, and primary differential data obtained by differentiating a time-beat waveform with respect to time and secondary differential data obtained by differentiating the primary differential data with respect to time. It is a biological reaction recording device characterized by being able to display at least one of them.

  The tenth invention (hereinafter referred to as invention 10) as an example of the present invention developed by developing the inventions 1 to 9 is the biological reaction recording apparatus according to any one of the inventions 1 to 9, wherein the living body A biological reaction recording apparatus characterized in that the reaction recording apparatus has means for detecting and displaying at least one of pulsation amplitude and amplitude distribution.

  An eleventh invention (hereinafter referred to as invention 11) as an example of the present invention developed from the invention 10 is the biological reaction recording apparatus according to the invention 10, wherein at least one of the amplitude of the pulsation and the amplitude distribution is provided. It is a biological reaction recording apparatus characterized by being able to display the temporal change of the above.

  A twelfth invention (hereinafter referred to as invention 12) as an example of the present invention developed by developing the inventions 1 to 11 is the biological reaction recording apparatus according to any one of the inventions 1 to 11, wherein the living body A biological reaction recording apparatus characterized in that the reaction recording apparatus has means for detecting and displaying at least one of pulsation intensity and intensity distribution.

  A thirteenth invention (hereinafter referred to as invention 13) as an example of the present invention developed by developing the invention 12 is the biological reaction recording device according to the invention 12, wherein at least one of the intensity of the pulsation and the intensity distribution is provided. It is a biological reaction recording apparatus characterized by being able to display the temporal change of the above.

  A fourteenth invention (hereinafter referred to as invention 14) as an example of the present invention developed by developing the inventions 10 to 13 is the biological reaction recording device according to any one of the inventions 10 to 13, wherein the beat The biological reaction recording apparatus is characterized in that the motion amplitude or intensity distribution can be displayed as a three-dimensional figure.

  A fifteenth invention (hereinafter referred to as invention 15) as an example of the present invention developed by developing the invention 14 is the biological reaction recording apparatus according to the invention 14, wherein the distribution of the amplitude or intensity of the pulsation is calculated as described above. A biological reaction recording apparatus capable of displaying a cross-sectional view at a predetermined position of a three-dimensional figure.

  A sixteenth invention (hereinafter referred to as invention 16) as an example of the present invention developed by developing the inventions 1 to 15 is the biological reaction recording device according to any one of the inventions 1 to 15, wherein the beat The biological reaction recording apparatus is characterized in that a motion detection site is a chest.

  The seventeenth invention (hereinafter referred to as invention 17) as an example of the present invention developed from the inventions 1 to 16 is the biological reaction recording device according to any one of the inventions 1 to 16, wherein the beat The biological reaction recording apparatus is characterized in that a motion detection site is an abdomen.

  An eighteenth invention (hereinafter referred to as invention 18) as an example of the present invention developed by developing the inventions 1 to 17 is the biological reaction recording device according to any one of the inventions 1 to 17, wherein the living body The reaction recording apparatus is a biological reaction recording apparatus characterized by having past data storage means for storing past data of the same living body to be measured, and capable of displaying changes in diagnostic information on the health state of the living body. is there.

  A nineteenth invention (hereinafter referred to as invention 19) as an example of the present invention developed by developing the inventions 1 to 18 is the biological reaction recording device according to any one of the inventions 1 to 18, wherein the living body The reaction recording apparatus is a biological reaction recording apparatus having statistical data storage means for storing statistical data of at least one of the same living body and a plurality of living bodies.

  A twentieth invention (hereinafter referred to as invention 20) as an example of the present invention developed from the inventions 1 to 19 is the biological reaction recording device according to any one of the inventions 1 to 19, wherein the living body The reaction recording device is a biological reaction recording device characterized in that it is a device capable of transmitting and receiving with other devices.

  A twenty-first invention (hereinafter referred to as invention 21) as an example of the present invention developed by developing the invention 20 is the biological reaction recording apparatus according to the invention 20, wherein the biological reaction recording apparatus is connected to a telemedicine system. A biological reaction recording apparatus characterized in that it is a device capable of transmitting and receiving and managing the health condition of a living body to be measured.

  A twenty-second invention (hereinafter referred to as invention 22) as an example of the present invention developed by developing the invention 20 or 21 is the biological reaction recording apparatus according to the invention 20 or 21, wherein the biological reaction recording apparatus is other. A biological reaction recording device characterized in that at least a pressure sensor is included in a portion of the device that is attached to a living body to be measured.

  The twenty-third invention (hereinafter referred to as invention 23) as an example of the present invention developed by developing the inventions 1-22 is the biological reaction recording apparatus according to any one of the inventions 1-22, wherein the pressure The sensor is a biological reaction recording apparatus characterized by being a two-dimensional pressure sensor configured by two-dimensionally arranging a plurality of pressure detection units (also referred to as pressure sensor units) or a plurality of pressure detection elements.

  A twenty-fourth invention (hereinafter referred to as invention 24) as an example of the present invention developed by developing the inventions 1 to 23 is the biological reaction recording apparatus according to any one of the inventions 1 to 23, wherein the pressure The sensor is a biological reaction recording apparatus, wherein the sensor is a two-dimensional pressure sensor in which a plurality of pressure detection units or a plurality of pressure detection elements are arranged concentrically.

  A twenty-fifth invention (hereinafter referred to as invention 25) as an example of the present invention developed by developing the inventions 1 to 24 is the biological reaction recording device according to any one of the inventions 1 to 24, wherein the pressure The sensor is a biological reaction recording device characterized in that it is a two-dimensional pressure sensor in which a plurality of pressure detection units or a plurality of pressure detection elements are arranged radially.

  A twenty-sixth invention (hereinafter referred to as invention 26) as an example of the present invention developed by developing the inventions 1 to 25 is the biological reaction recording device according to any one of the inventions 1 to 25, wherein the pressure The sensor is a two-dimensional pressure sensor having at least three pressure detection elements or pressure detection units in two directions in which a plurality of pressure detection units or a plurality of pressure detection elements are orthogonal to each other. is there.

  A twenty-seventh invention (hereinafter referred to as invention 27) as an example of the present invention developed from the inventions 1 to 26 is the biological reaction recording apparatus according to any one of the inventions 1 to 26, wherein the pressure A biological reaction recording apparatus, wherein the sensor is a pressure sensor configured by two-dimensionally arranging a plurality of pressure detection elements on a support substrate.

  A twenty-eighth invention (hereinafter referred to as invention 28) as an example of the present invention developed by developing the inventions 1-27 is the biological reaction recording apparatus according to any one of the inventions 1-27, wherein the pressure A biological reaction recording apparatus having at least one three-dimensional pressure sensor as a sensor.

  A twenty-ninth invention (hereinafter referred to as invention 29) as an example of the present invention developed by developing the inventions 1-28 is the biological reaction recording apparatus according to any one of the inventions 1-28, wherein the pressure The sensor has a pressure transmission part between a part of the living body to be measured that contacts the surface of the measurement part and the pressure detection part of the pressure sensor, and the pressure transmission part is in contact with the surface of the measurement part in its cross section. The living body reaction recording apparatus is characterized in that an area of a contacting portion is larger than an area on the pressure detection unit side.

  A thirtieth invention (hereinafter referred to as invention 30) as an example of the present invention developed from the inventions 1 to 29 is the biological reaction recording device according to any one of the inventions 1 to 29, wherein the pressure A biological reaction recording apparatus, wherein the pressure detection unit of the sensor is a pressure sensor (hereinafter also referred to as a piezoelectric pressure sensor or a piezoelectric pressure sensor) that is a pressure detection unit using a piezoelectric effect.

  The thirty-first invention (hereinafter referred to as invention 31) as an example of the present invention developed by developing the invention 30 is a biological reaction recording apparatus according to the invention 30, wherein the pressure sensor uses a semiconductor. This is a biological reaction recording apparatus.

  A thirty-second invention (hereinafter referred to as invention 32) as an example of the present invention developed by developing the inventions 1-31 is the biological reaction recording apparatus according to any one of the inventions 1-31, wherein the pressure A biological reaction recording apparatus characterized in that the pressure detection unit has a pressure sensor (hereinafter also referred to as a capacitance-type pressure sensor) that is a pressure detection unit using a change in capacitance as a sensor. .

  A thirty-third invention as an example of the present invention developed from the thirty-second invention (hereinafter referred to as thirty-third invention) is the biological reaction recording apparatus according to the thirty-second invention, wherein the pressure sensor is formed using a semiconductor. It is a biological reaction recording device characterized by being a pressure sensor.

  A thirty-fourth invention (hereinafter referred to as invention 34) as an example of the present invention developed by developing the inventions 23 to 33 is the biological reaction recording apparatus according to any one of the inventions 23 to 33, wherein the pressure The biological reaction recording apparatus is characterized in that the pressure detection part or the pressure transmission part of the sensor is arranged in a region where the outer periphery is generally a circle.

  A thirty-fifth invention (hereinafter referred to as invention 35) as an example of the present invention developed by developing the inventions 23 to 33 is the biological reaction recording device according to any one of the inventions 23 to 33, wherein the pressure The biological reaction recording apparatus is characterized in that the pressure detection part or the pressure transmission part of the sensor is arranged in a region where the outer periphery is generally a polygon having a square shape or more.

  A thirty-sixth invention (hereinafter referred to as invention 36) as an example of the present invention developed by developing the inventions 1 to 35 is the biological reaction recording device according to any one of the inventions 1 to 35, wherein the pressure The biological reaction recording apparatus is characterized in that the outer shape of the exterior body on which the sensor is mounted is a round shape such as a circular shape or an oval shape.

  A thirty-seventh invention (hereinafter referred to as invention 37) as an example of the invention made by developing the inventions 1-36 is the biological reaction recording device according to any one of the inventions 1-36, wherein the pressure The range in which the pressure of the sensor can be detected is a range of a circumscribed circle having a diameter of 30 mm or more.

  According to a thirty-eighth aspect of the present invention developed from the thirty-seventh aspect of the present invention (hereinafter, referred to as the thirty-eighth aspect), the biosensor recording apparatus according to the thirty-seventh aspect is characterized in that the pressure-detectable range of the pressure sensor is its circumscribing area. A biological reaction recording apparatus characterized in that the diameter of a circle is in a range of 40 mm or more.

  A thirty-ninth invention (hereinafter referred to as invention 39) as an example of the present invention developed by developing the inventions 1-38 is the biological reaction recording apparatus according to any one of the inventions 1-38, wherein the pressure The biological reaction recording device is characterized in that the shape of at least a portion of the sensor contacting the living body to be measured is deformable.

  40th invention as an example of the present invention developed from the inventions 1 to 39 (hereinafter referred to as invention 40) is the biological reaction recording apparatus according to any one of the inventions 1 to 39, wherein the living body The reaction recording apparatus is configured to calculate a difference in contact pressure between the pressure sensor and the living body to be measured or a difference in contact pressure between at least two pressure detecting elements or pressure detecting portions constituting the pressure sensor and the living body to be measured. A biological reaction recording apparatus having a contact pressure detecting means capable of detecting at least one of them.

  The forty-first invention (hereinafter referred to as invention 41) as an example of the present invention developed by developing the invention 39 or 40 is the biological reaction recording apparatus according to the invention 39 or 40, wherein the biological reaction recording apparatus comprises: A biological reaction recording apparatus comprising: means for changing the contact pressure corresponding to the contact pressure detected by the contact pressure detecting means.

  42nd invention (henceforth the invention 42) as an example of this invention made | formed by developing said invention 1-41 WHEREIN: The biological reaction recording device of any one of invention 1-41 WHEREIN: The said biological body The reaction recording apparatus is a biological reaction recording apparatus having means for attaching the pressure sensor to a measurement subject in a state where the measurement can be performed at a measurement part of the measurement subject.

  A forty-third invention (hereinafter referred to as invention 43) as an example of the present invention developed by developing the invention 42 is a biological reaction recording apparatus according to the invention 42, wherein the pressure sensor is attached to a measurement subject. Is a biological reaction recording apparatus characterized in that is a means using suction force.

  The forty-fourth invention (hereinafter referred to as invention 44) as an example of the present invention developed by developing the invention 42 or 43 is the biological reaction recording apparatus according to the invention 42 or 43, wherein the pressure sensor is used as a living body to be measured. The biological reaction recording apparatus is characterized in that the means to be attached to is a means utilizing adhesive force.

  Forty-fifth invention (hereinafter referred to as invention 45) as an example of the present invention developed by developing the inventions 1-44 is the biological reaction recording apparatus according to any one of the inventions 1-44, wherein the living body The reaction recording apparatus is a recording apparatus capable of presenting at least one of the measurement data, the detection data, and the diagnosis information of the living body's health condition in real time as at least one of a still image and a moving image. It is a recording device.

  Forty-sixth invention (hereinafter referred to as invention 46) as an example of the present invention developed by developing the inventions 1 to 45 is the biological reaction recording apparatus according to any one of the inventions 1 to 45, wherein the measurement is performed. The biological reaction recording apparatus is characterized in that at least part of the detected data and the detected data is normalized data.

  Forty-seventh invention (hereinafter referred to as invention 47) as an example of the present invention developed by developing the inventions 1-46 is the biological reaction recording device according to any one of the inventions 1-46, wherein the living body The reaction recording apparatus is a biological reaction recording apparatus capable of displaying at least one of the pulsation charts as the detection data.

  The forty-eighth invention (hereinafter referred to as invention 48) as an example of the present invention developed from the invention 47 is the biological reaction recording device according to the invention 47, wherein the biological reaction recording device is used as the detection data. A biological reaction recording apparatus capable of displaying an electrocardiogram and an electrocardiogram.

  A forty-ninth invention (hereinafter referred to as invention 49) as an example of the present invention developed by developing the inventions 1 to 48 is the biological reaction recording apparatus according to any one of the inventions 1 to 48, wherein the living body The reaction recording apparatus is a biological reaction recording apparatus having sampling means for sampling at least one of the measurement data of the sensor and the detection data.

  A fifty-th invention as an example of the present invention developed from the first to fourth aspects of the present invention (hereinafter referred to as the present invention 50) is the biological reaction recording apparatus according to any one of the first to 49th aspects of the present invention. The biological reaction recording apparatus, wherein the reaction recording apparatus includes a noise removing unit that removes noise from at least one of processing data such as measurement data of the sensor and detection data.

  A fifty-first invention (hereinafter referred to as invention 51) as an example of the present invention developed from the inventions 1 to 50 is the biological reaction recording apparatus according to any one of the inventions 1 to 50, wherein the living body The reaction recording apparatus has a condition changing unit that allows a user of the biological reaction recording apparatus to change at least one of a data processing condition, a sampling condition, and a noise removal condition. It is.

  A fifty-second invention (hereinafter referred to as invention 52) as an example of the invention made by developing the inventions 1 to 51 is the biological reaction recording apparatus according to any one of the inventions 1 to 51, wherein at least one In the signal processing of the data measured as the pressure change of the movement of the two pulsation detection parts, the cutoff frequency or time constant of the filter of the signal processing circuit that processes the measurement data of the pressure sensor is set as a parameter (hereinafter referred to as parameter 1). And using the result of the signal processing of the measurement data with the parameter 1 having a different value for the same or the same type of pressure sensor measurement data as diagnostic information on the health condition of the living body. It is the biological reaction recording device characterized.

  A thirty-third invention (hereinafter referred to as invention 53) as an example of the present invention developed by developing the inventions 10 to 52 is the biological reaction recording device according to any one of the inventions 10 to 52, wherein the beat The biological reaction recording apparatus is characterized in that a measurement area of a living body when detecting or displaying either or both of an amplitude distribution and an intensity distribution of a movement is a circular range having a diameter of at least 5 mm.

  54th invention (henceforth the invention 54) as an example of this invention made | formed by developing said invention 1-53 is the biological reaction recording device of any one of invention 1-53, The said biological body. The reaction recording apparatus has data for comparison with the detection data (hereinafter also referred to as reference data), and has means for comparing the detection data with the reference data. It is.

  The fifty-fifth invention (hereinafter referred to as invention 55) as an example of the present invention developed from the present invention 54 is the biological reaction recording device according to the invention 54, wherein the biological reaction recording device uses the reference data. A biological reaction recording apparatus comprising at least one of a changing means and an adding means.

  The fifty-sixth invention (hereinafter referred to as invention 56) as an example of the present invention developed by developing the invention 54 or 55 is the biological reaction recording device according to the invention 54 or 55, wherein the detection data and the reference data are used. The biological reaction recording apparatus is characterized in that the means for comparing is means for detecting and displaying a difference between the detection data and the reference data.

  A fifty-seventh invention (hereinafter referred to as invention 57) as an example of the present invention developed by developing the inventions 54 to 56 is the biological reaction recording apparatus according to any one of the inventions 54 to 56, wherein the reference is made. The biological reaction recording apparatus characterized in that the data includes data using the extreme values of the reference data.

  The 58th invention (hereinafter referred to as invention 58) as an example of the present invention developed by developing the inventions 1 to 57 is the biological reaction recording apparatus according to any one of the inventions 1 to 57, wherein the living body The reaction recording apparatus is a biological reaction recording apparatus having a pattern matching diagnostic unit that generates diagnostic information using a pattern matching technique.

  A fifty-ninth invention (hereinafter referred to as invention 59) as an example of the present invention developed from the first to fifth inventions is the biological reaction recording apparatus according to any one of the first to 58th inventions. The reaction recording apparatus is a biological reaction recording apparatus having means for setting a measurement condition of a pulsation diagram using an area between a time-beat waveform of a pulsation diagram and a time axis. .

  A 60th invention as an example of the present invention made to solve the problem (hereinafter also referred to as the invention 60) includes at least one of a cardiac apex beat, a right ventricular beat, and a left atrial beat. As a measurement result of pressure change, at least one of pulsation, ascending aorta pulsation, pulmonary artery (including at least one of pulmonary artery trunk and central pulmonary artery), abdominal aorta pulsation or liver pulsation A novel biological reaction recording device capable of detecting and recording, wherein the biological reaction recording device is measured as a pressure sensor capable of measuring the movement of at least one pulsation detection site as a pressure change. A data processing means such as an arithmetic processing unit capable of detecting biological information based on amplifying means such as a signal and the measured data; at least a main part of the measured data; Storage means capable of storing at least one of the display means and display means, and the storage means can store at least one of the measurement data and at least one of the detection data, and the same measured object The biological reaction recording apparatus is characterized in that it can store a change in detection data of a living body over time.

  The 61st invention as an example of the present invention developed from the invention 60 (hereinafter referred to as invention 61) is the biological reaction recording apparatus according to the invention 60, wherein the biological reaction recording apparatus includes an electrocardiogram measurement sensor and a heart sound. It is a biological reaction recording device characterized by having a figure measuring sensor.

  A twenty-second invention (hereinafter referred to as invention 62) as an example of the present invention developed by developing the invention 60 or 61 is the biological reaction recording apparatus according to the invention 60 or 61, in which the biological reaction recording apparatus is covered. A biological reaction recording apparatus characterized in that at least one of electrocardiogram and electrocardiogram data of a measurement living body can be input from the outside of the biological reaction recording apparatus and can be synchronized with the at least one data. .

  A 63rd invention as an example of the present invention made to solve the problem (hereinafter also referred to as an invention 63) includes at least one of a cardiac apex beat, a right ventricular beat, and a left atrial beat. At least one of pulsation or ascending aorta pulsation, pulmonary artery (including at least one of pulmonary artery trunk and central pulmonary artery) pulsation, abdominal aorta pulsation or liver pulsation is used as a measurement result of pressure change. A novel biological reaction recording method capable of detecting and recording, wherein the biological reaction recording method measures the movement of at least one pulsation detection site as a pressure change at a plurality of locations in the vicinity of the location to be measured. And at least one of the pulsation detection site movements, the biological information is obtained from the data measured as the pressure change by the pressure sensor. It means for output, means for storing the detected biometric information, a biological reaction recording method characterized by using the means for displaying the diagnostic information on the state of health of the living body based on the detected biological information.

  The sixty-fourth invention (hereinafter referred to as invention 64) as an example of the present invention developed from the invention 63 is the biological reaction recording method according to the invention 63, wherein the biological reaction recording method includes an electrocardiogram measurement sensor and a heart sound. A biological reaction recording method using a figure measuring sensor.

  The 65th invention as an example of the present invention developed from the invention 63 or 64 (hereinafter referred to as invention 65) is the biological reaction recording method according to the invention 63 or 64, wherein the electrocardiogram and heart sound of the living body to be measured. 64. A biological reaction recording method characterized in that it can be input from the outside of the biological reaction recording device using at least one of the data in the figure, and can be synchronized with at least one data according to claim 63.

  The 66th invention (hereinafter referred to as invention 66) as an example of the present invention developed from the inventions 63 to 65 is the biological reaction recording method according to any one of the inventions 63 to 65, wherein the beat The biological reaction recording method is characterized in that at least one of the chest and abdomen is targeted as a motion detection site.

  The 67th invention (hereinafter referred to as invention 67) as an example of the present invention developed from the inventions 63 to 66 is the biological reaction recording method according to any one of the inventions 63 to 66, wherein the living body Electrocardiogram, phonocardiogram, and pulsation chart as diagnostic information of the health condition of the patient, and the first derivative data obtained by differentiating the time-beat waveform with time and the second derivative data obtained by differentiating the first derivative data with time. It is the biological reaction recording method characterized by using the information containing at least one of these.

  The 68th invention (hereinafter referred to as invention 68) as an example of the present invention developed by developing the inventions 63 to 67 is the biological reaction recording method according to any one of the inventions 63 to 67, in the chest. A biological reaction recording method using means for detecting and displaying at least one of pulsation amplitude, amplitude distribution, intensity, and intensity distribution.

  The 69th invention (hereinafter referred to as invention 69) as an example of the present invention developed from the inventions 63 to 68 is the biological reaction recording method according to any one of the inventions 63 to 68, wherein the living body The reaction recording method is a biological reaction recording method using means for comparing the detected data detected from the measured data with reference data.

  Conventionally, the pulsation is measured as the value of the whole or average value of the range where the microphone is in close contact with the representative point in the chest, as described above, with the patient entering a noise-proof environment such as a soundproof room. Then, the apex rhythm diagram was obtained and the record was recorded on paper, but this could not be used for actual diagnosis as described above.

  As in each example of the present invention, in the measurement by the pressure sensor, for example, with respect to one pulsation, the characteristic that it is possible to distinguish and measure the pressures at a plurality of locations adjacent to a living body is an important feature that could not be expected in the past. In addition to being able to obtain useful information, it has the great effect of bringing long-lasting progress to diagnosis using it. Furthermore, the feature of being able to measure the pressure at multiple locations at the same time for a single pulsation is the most important information that could not be expected in the past, such as the ability to observe complex heart movements in more detail. There is a great effect that it can be obtained.

  Here, it is possible to measure at the same time, for example, when data is sampled at 1/1000 second or 1200 second, for example, when measurement data is temporarily stored in memory and read out. However, it is not limited to this. For example, when the number of pressure detection elements of the pressure sensor is n and n is a very large number In many cases, there is no problem in handling data within n seconds of 1000 minutes as data measured simultaneously. It is possible to obtain important information on heart movement by handling data within approximately 0.3 seconds as data measured at the same time.

  As a result of research by the inventors of the present invention, it is particularly preferable to obtain truly simultaneous data as a measured value as in the above example from the viewpoint of data utilization. In synchronization with at least one of the electrocardiogram and the electrocardiogram, data taken 0.02 seconds after the beginning of the QRS wave of the electrocardiogram or a specific position of one sound of the electrocardiogram, or data after 0.04 seconds or 0 Taking the data after 0.08 seconds can provide important information and is particularly preferable.

  However, from a medical point of view, the present invention is not limited to this, and even if the measured values within 0.1 seconds are treated as simultaneously measured data, the amplitude and intensity of the pulsation can be grasped fairly accurately. Even if the measured values within 3 seconds are treated as simultaneously measured data, it is possible to roughly grasp the movement of the heart, so it can be said that the data measured with a time difference within 0.3 seconds is measured simultaneously. .

  As the data relating to the heart, it is practically preferable to use an average of data of at least three beats as the data, and the accuracy of diagnosis can be improved.

  From the viewpoints of simplifying the measurement system, obtaining accurate data suitable for the purpose of diagnosis, and making an appropriate diagnosis according to the medical condition, sampling for multiple pulsations as appropriate, It is also possible to obtain representative beat information of multiple beats.

  Further, each of the above-mentioned inventions is obvious from the following description, but it can be developed to bring about many new inventions, and many variations are possible.

  For example, the measurement data is stored in a part of the storage means, a filter is inserted between the measurement data storage means and the signal amplification means, and the signal processing is performed by changing the filter variously. A biological reaction recording apparatus characterized in that a graph is detected and a signal obtained as a result of the detection can be used for diagnosis or the like.

  The present invention makes it possible to record the biological reaction of the chest and abdomen without using a special measurement room such as a soundproof room, for example, in an outpatient examination room or a hospital room, and also by a single doctor. This has the great effect of making it possible to make an accurate diagnosis of cardiovascular diseases.

  Examples of embodiments of the present invention will be described below with reference to the drawings. The drawings used for the description schematically show the dimensions, shapes, arrangement relationships, and the like of each component to the extent that an example of the present invention can be understood. For convenience of explanation of the present invention, there may be cases where the enlargement ratio is partially changed for illustration, and the drawings used for explanation of the examples of the present invention may not necessarily be similar to the actual objects and descriptions of the embodiments. Moreover, in each figure, about the same component, it attaches and shows the same number, The overlapping description may be abbreviate | omitted.

  Conventionally, even if an extremely large device as described above is used and environmental noise is suppressed, the living body to be measured enters a special measurement room such as a soundproof room, and various sensors for measurement are mounted on the skin. I put a recording device in the next room, etc., and sometimes I took a heartbeat diagram while watching the state of the living body to be measured and sometimes correcting the state of the sensor through the communication means, sometimes through the window.

  However, the heart diagram taken in this way is not data in the natural state of the living body to be measured, and it was thought that the actual use of the heart diagram could not be expected with a few exceptions. The actual situation was.

  The present invention can be applied to a patient who needs a heartbeat diagram that has been thought to be unusable for correct medical treatment, and can be applied to a patient who needs it. A small and inexpensive recording device that can be used at the bedside of the hospital and records past data and can be used for continuous medical care of patients. It provides educational methods.

  One of the notable features of the technical idea of the present invention is that the biological reaction recording apparatus of the present invention has a pressure sensor disposed in at least one position of the chest or abdomen of the living body, and apex pulsation, right ventricular pulsation, and left Detecting and recording as pressure change at least one of heart beat, ascending aorta beat, pulmonary artery beat, abdominal aorta beat or liver beat as at least one kind of beat of atria. A new biological reaction recording apparatus capable of measuring a plurality of pressures in the vicinity of a measured position of a living body with respect to one pulsation using a pressure sensor, and storing the measurement data in the measurement data storage means There is a place where measurement data at a plurality of locations can be stored.

  One of the features that should be noted in the technical idea of the present invention is that the pressure changes at the plurality of locations can be distinguished and stored. These pressure changes at a plurality of locations are simultaneously measured so that, for example, the complex movement of the heart can be observed in more detail.

  Furthermore, the detection data storage means can also store the time course of biological information.

  One of the remarkable features of the technical idea of the present invention is that the biological reaction recording device can be reduced in size and weight so that even a doctor can easily carry it. It is in a place where it can be made small enough to fit in.

  FIG. 1 is a block diagram illustrating a biological reaction recording apparatus as an embodiment of the present invention. 1, reference numeral 200 denotes a biological reaction recording apparatus as an embodiment of the present invention, 201 a pressure sensor that measures pulsation, 202 a heart sound sensor that measures a heart sound, 203 an electrocardiogram sensor that measures an electrocardiogram, 220 is a control / measurement data processing unit, 230 is a storage unit, 240 is a display unit, 211 is a wiring connecting the pressure sensor 201 and the control / measurement data processing unit 220, and 212 is a heart sound sensor 202 and a control / measurement data processing unit 213 is a wiring connecting the electrocardiogram sensor 203 and the control / measurement data processing unit 220, 231 is a wiring connecting the storage unit 230 and the control / measurement data processing unit 220, and 241 is a display unit. This wiring connects 240 and the control / measurement data processing unit 220.

  The pressure sensor 201 is a pressure sensor having a plurality of pressure detection elements or pressure detection units that can detect pressure measurements at a plurality of locations as data distinguished from each other. For example, a piezoelectric element such as a piezo element made of a semiconductor is used. Can be configured.

  The heart sound sensor 202 is a sensor for measuring a heart sound, and a conventional heart sound sensor can also be used.

  The electrocardiogram sensor 203 is a sensor for measuring an electrocardiogram, and a conventional electrocardiogram electrode can also be used.

  In FIG. 1, a pressure sensor 201, a heart sound sensor 202, and an electrocardiogram sensor 203 are respectively arranged at measurement points of a living body to be measured, and each measurement data is sent to the control / measurement data processing unit 220 via each wiring.

  The measurement data sent from the pressure sensor 201 is processed in the control / measurement data processing unit 220 as pulsation diagram creation data and other data, stored in the storage unit 230, and displayed on the display unit 240 as necessary. The The other data may be unnecessary, but includes, for example, a two-dimensional distribution of pressure detection intensity within a predetermined range in the chest and contact pressure.

  The measurement data sent from the heart sound sensor 202 and the electrocardiogram sensor 203 are processed by the control / measurement data processing unit 220 as data for a heart sound diagram and an electrocardiogram, respectively, stored in the storage unit 230, and displayed as necessary. Is displayed.

  FIG. 2 is a block diagram for explaining a biological reaction recording apparatus that can also perform remote management as an embodiment of the present invention.

  In FIG. 2, reference numeral 300 denotes a biological reaction recording system as an embodiment of the present invention, 301 a pressure sensor that measures pulsation, 305 a a heart sound sensor that measures a heart sound, 305 b an electrocardiogram sensor that measures an electrocardiogram, and the like. , 320 is a control / measurement data processing unit, 330 is a storage unit, 340 is a display unit, 350 is a remote management unit, 311 is a communication means for connecting the pressure sensor 301 and the control / measurement data processing unit 320, 315a is Contact means for connecting the sensor 305a and the control / measurement data processor 320, 315b for contact between the sensor 305b and the control / measurement data processor 320, 331 for the storage 330 and the control / measurement data processor 320 341 is a communication unit for connecting the display unit 340 and the control / measurement data processing unit 320, and 351 is a remote tube. A communication means between the parts 350 and the control and measurement data processing unit 320. At least a part of the contact means can be configured using communication means such as wireless communication or optical communication.

  In FIG. 2, a sensor 305 such as a pressure sensor 301 for measuring a pulsation, a heart sound sensor for measuring a heart sound and an electrocardiogram sensor for measuring an electrocardiogram, a control / measurement data processing unit 320, a storage unit 330, and a display unit 340 are biological reactions. Although it corresponds to a recording device, it is a major difference from the case of FIG. 1 in that some of the contents of the control / measurement data processing unit 320, the storage unit 330, and the display unit 340 are provided in the remote management unit 350.

  The living body reaction recording apparatus system of FIG. 2 can perform the health management of the living body to be measured based on the measurement information of the sensor by attaching the necessary minimum part of the living body reaction recording apparatus to the living body to be measured.

  FIG. 3 is a block diagram for explaining an example of measurement data processing in the biological reaction recording apparatus as an embodiment of the present invention. The flow of processing is as follows. In the figure, numerals 271 to 287 described in squares are symbols for explaining processing steps, processing contents, functions, and the like. Hereinafter, typical steps of measurement data processing will be described.

  In step 271, the measurement data of the pressure sensor and other sensors are captured, and the measurement data sampled at 12000 points for 10 seconds is stored in the memory 283, and the measurement data is input to the amplification / noise removal unit shown in step 272. The measurement data is digital data. The measurement data measured by the pressure sensor that detects pulsation as pressure change is the data measured by distinguishing multiple pressure changes at the pulsation measurement position. Can be used to know the amplitude distribution and intensity distribution.

  In the amplification and noise removal in the amplification / noise removal unit in step 272, the conditions for noise removal such as the filter conditions are set and the measurement data is amplified.

  For example, in the case of a pulsation diagram, it is easy to evaluate by normalizing the data so that the maximum value of the pulsation amplitude appearing in 10 seconds is 1000.

  The data amplified in step 272 is stored in the memory 283 and input to the waveform / graphic processing unit in step 273. In the waveform / graphic processing unit in step 273, for example, if the data is for pulsation charts (measurement data by a pressure sensor), electrocardiograms or phonocardiograms, a graph is created, and the amplitude distribution of the pulsations In the case of an intensity distribution, graphic processing is performed.

  The data that has undergone the waveform / graphic processing in step 273 is stored in the memory 283 and the feature extraction processing is performed in step 274. In the feature extraction process, for example, features such as extraction of extreme values in a graph of a pulsation diagram, comparison of the magnitudes of extreme values, shapes of primary differential waveforms and secondary differential waveforms, and waveforms of pulsation diagrams are extracted.

  The data subjected to the feature extraction process in step 274 is stored in the memory 283 as detection data, and the extracted waveform, feature, etc. are evaluated in step 275. For example, the shape of the graph of the apex rhythm may vary greatly depending on the noise removal conditions in the amplification / noise removal unit in step 272. In step 275, it is determined whether or not the graph or figure obtained as a result of the waveform / graphic processing in step 273 is appropriate for the diagnosis of the living body to be measured. If you want to change the processing conditions, go to Step 284 and set new or changed amplification / noise removal conditions and feature extraction conditions in the amplification / noise removal condition setting unit, feed back to steps 272, 274, etc. Amplification, noise removal, and feature extraction are performed according to

  If it is determined in step 275 that the extracted waveform, feature, or the like is appropriate, it is stored in the memory 283 and a primary diagnosis or evaluation is performed in step 276 to create detection data such as biological information. When possible, detection data is sent to step 277 and stored in the memory 283. In step 278, information other than information based on the current measurement data such as blood pressure and drug administration information is stored as necessary. The secondary diagnosis or evaluation is performed by using the storage unit 286.

  If it is determined in step 278 that further examination is necessary, the process proceeds to steps 284 and 285, where, for example, the processing as described above is performed, and further diagnosis and evaluation are performed.

  Even when it is determined in step 275 or 278 that the extracted waveform, feature, or the like is not appropriate, it can be stored in the memory 283 as necessary.

  3 may be performed automatically or semi-automatically according to a program or the like, may be performed as a diagnosis / evaluation by a specialist, or may be performed as a combination thereof.

  If it is determined in the first diagnosis or evaluation in step 276 that there is a problem in creating detection data such as biometric information, the process moves to the processing condition setting unit in step 285 to set the waveform / graphing conditions and the like. For example, the process returns to step 273 to perform waveform / graphic processing.

  The result of the secondary diagnosis or evaluation is stored in the memory 283 and primary diagnosis information is created in step 279.

  The primary diagnosis information created in step 279 is stored in the memory 283 and the process proceeds to step 280, and the secondary diagnosis information can be created by referring to the reference data storage unit 287 as necessary.

  The reference data storage unit stores, for example, time-change information such as detection data of the same living body to be measured, statistical data that is useful for diagnosis, model patterns of pulsation charts, etc. Simple diagnosis can be realized.

  The secondary diagnosis information is stored in the memory 283, and if necessary, the process proceeds to step 282 and is displayed on the display device, and the process proceeds to step 281 to create health information of the living body to be measured.

  The health information of the measurement subject created in step 281 is displayed on the display device in step 282.

  The display on the display device is not limited to this, and if necessary at each step, the process can move to step 282 each time and can be displayed on the display device. Further, the display screen can be divided into a plurality of parts and displayed at the same time, and the results of a plurality of steps can be displayed in a list. By configuring in this way, it is possible to make a more accurate and quick diagnosis.

  In the feature extraction and diagnosis of the pulsation diagram, the pulsation diagram itself is naturally important information, but as will be apparent from the examples described later, the differential data of the pulsation diagram also plays an important role. For example, when extracting features or evaluating features according to a program, performing automatic diagnosis or semi-automatic diagnosis, or interpreting a pulsation diagram that is difficult to judge, use the first derivative or second derivative data. In many cases, feature extraction, its evaluation, and various diagnoses can be easily performed.

  Each of the steps can have many variations. For example, the apex rhythm diagram as a graph obtained as a result of the graphic processing changes when the noise removal condition in step 272 is changed. What processing conditions should be used at what time greatly affects the accuracy of diagnosis of the apparatus. The example of the biological reaction recording apparatus of the present invention has these conditions as a part of the invention.

  The measurement data includes a measurement value by a pressure sensor of a corresponding pulsation in the chest or abdomen, but may include a measurement value by an electrocardiogram sensor and a heart sound sensor. The data for the electrocardiogram and the data for the electrocardiogram are the data measured so that the pulsatogram can be synchronized by the measuring means different from the biological reaction recording apparatus as an example of the present invention. It is also possible to configure the apparatus so that it is used by receiving it as external input data. By doing so, it is possible to reduce the size and cost of the apparatus.

  Further, as described in the means for solving the problems, the biological reaction recording apparatus as an example of the present invention covers only the pressure sensor or the minimum part including the same in the configuration shown in FIG. For example, a hospital can be attached to a measurement living body, and a transmission / reception function between the part and an external device is provided in a necessary part of the part to be attached to the measurement biological body and the external device. Can be used for remote health management, or by providing a portable device such as a personal computer, a mobile phone, or a wristwatch with the necessary functions as the external device, and as a whole, a biological reaction recording device can be configured and widely used. It can be used for health management of many people.

  FIG. 4 is a diagram for explaining an example of a pressure sensor for measuring the pulsation of the biological reaction recording apparatus as an embodiment of the present invention, in which the outer shape of the sensor is circular.

  In FIG. 4, reference numeral 201a is a pressure sensor, 241a to 241c, 242a to 242c, 243a to 243c are pressure sensor units for detecting pulsation of the living body, and 244a to 244d are pressure sensor units for detecting contact pressure with the living body. Is a semiconductor substrate, 245 is an inner wall of the outer periphery of the pressure sensor, 246 is an outer wall of the outer periphery of the pressure sensor, 247 is a space formed between the outer wall 246 and the inner wall 245, and 247a partitions the space 247. The partition portions 249a to 249d are wearing position correcting means, and 249e to 249h are microphones that can also be used for heart sound sensors.

  In FIG. 4, each pressure sensor is a piezo element formed on a semiconductor substrate 248.

  For example, the pressure sensor 201a is connected to the control / measurement data processing unit via wiring as shown in FIG. 1, and sends the measurement data of each sensor to the control / measurement data processing unit, and if necessary, It is also possible to measure based on a command sent from the control / measurement data processing unit and send the measurement value to the control / measurement data processing unit.

  The pressure sensor units 244a to 244d that detect the contact pressure with the living body can detect the contact pressure with the living body, and depending on the purpose of use of the biological reaction recording device, for example, according to a command from the control / measurement data processing unit Based on this, there may be provided means for changing the relative position between the pressure sensor 201a and the living body, such as the mounting position correcting means 249a to 249d.

  The space portion 247 may be divided into a plurality of locations, and may be used by being divided into a portion that performs a suction action and a portion that performs a pressing action.

  Depending on the purpose of use of the biological reaction recording device, the pressure in the space 247 can be changed and used to attach / detach the pressure sensor 201a to / from the living body. For example, when the space portion 247 is divided into a plurality of locations by the partition portion 247a in FIG. 4, the pressure in the space portion can be changed for each divided location, and the pressure sensor 201a is applied to the living body. It can be used for attaching / detaching or changing the relative position of the pressure sensor 201a and the living body.

  The illustrated portions of the microphones 249e to 249h may include the microphone itself, and the position of the microphone itself may be used as a sound collection hole, and a sound detection unit may be provided inside or on the back side of the substrate 248. By doing in this way, size reduction can be achieved and a sound detection characteristic can also be improved.

  Depending on the purpose of use of the biological reaction recording device, the number of pressure sensor parts for detecting the pulsation of the living body may be increased or decreased, but it is preferably three or more and particularly preferably two-dimensionally arranged. Furthermore, the pressure sensor units 244a to 244d for detecting the contact pressure with the living body may not be provided depending on the purpose of use of the biological reaction recording apparatus.

  Even if the pressure sensor 201a is configured without any or all of the mounting position correcting means 249a to 249d, the microphones 249e to 249h, and the space portion 247, it can be used as a pressure sensor for detecting pulsation.

  The pressure sensor 201a as shown in FIG. 4 is an example in which the pressure sensor unit for detecting the pulsation of the living body is arranged two-dimensionally in 3 rows and 3 columns, and the pressure change of the living body at the position of each pressure sensor unit, respectively. Can be measured so that the pulsation of the living body can be accurately detected. And if the measurement system is configured so that it can measure the pressure change of the living body at the position of each pressure sensor at the same time or measure it as a movie, it can be observed equivalent to or better than the palpation of the heart, Highly reliable examination can be performed.

  The number and arrangement of the two-dimensional pressure sensor units or pressure detection elements are not limited to the above. If the number of sensor units is arranged in a matrix of 3 × 3, 5 × 5, 7 × 7, etc., a sensor that can grasp the actual movement of the heart with a relatively small number of sensor units can be realized at low cost. In addition to the matrix form, the arrangement can be made concentrically or radially from the center to increase detection accuracy. From the viewpoint of operability, detection accuracy, etc., the number and manner of arrangement capable of detecting the center of the sensor unit are preferable.

  Although not shown, a well-known element MEMS can be used as a pressure sensor for detecting pressure changes at a plurality of locations.

  By utilizing semiconductor technology, a very large number of pressure sensor units can be constructed and used.

  These pressure sensor units are preferably used not only for detecting the pressure of the pulsation itself, but also for instructing correction to be a position where the pressure sensor is to be applied to the living body or an appropriate position. By doing so, a pressure sensor that is easy to use and can be measured accurately can be realized.

  The outer peripheral shape of the pressure sensor 201a is circular.

  The shape of the outer circumference of the pressure sensor is extremely important for actual measurement. Usually, the pressure sensor is applied to the skin of the living body with some pressure, so that the living body is free of pain and other pain. If the outer shape of the sensor is circular or elliptical, it is possible to perform more accurate measurement without causing pain even if the sensor is pressed strongly against the living body. For the same reason or improvement of measurement accuracy, if a flexible pressure sensor is used, a decrease in measurement accuracy due to the shape of the chest can be reduced, for example, in the case of a person with a conspicuous rib. Furthermore, it is preferable to round the corners when using a shape that is not circular but is based on, for example, a quadrilateral or more polygon.

  It is convenient to add an additional function if the outer shape of the sensor is a polygon larger than a square.

  As the outer shape of the pressure sensor, various shapes can be selected according to the type and form of the pressure detecting element used for the pressure sensor, the purpose of measurement, the condition of the living body to be measured and the like.

  The measurement of pulsation is a concern for many noises. As a matter of course, it is also useful to selectively use noise suppression means conventionally considered in heart sound measurement for this noise removal.

  FIG. 5 is a diagram for explaining an example of a pressure sensor for measuring the pulsation of the biological reaction recording apparatus as an embodiment of the present invention, in which the outer shape of the sensor is a quadrangle.

  In FIG. 5, reference numeral 201b is a pressure sensor, 251a to 251c, 252a to 252c, 253a to 253c, 254a to 254f are pressure sensor parts for detecting the pulsation of a living body, 258 is a substrate, and 255 is an outer wall of the outer periphery of the pressure sensor. It is.

  The pressure sensors 253a to 253c can measure pulsations at corresponding positions. The pressure sensor units 254a to 254f can detect the pressure at the position, and for example, can acquire information supplementing the pressure information detected by the pressure sensor units 253a to 253c.

  The pressure sensor for detecting a pressure change in the present invention requires a specially considered condition as known in signal amplification, noise processing, and the like because the living body to be measured is a living body. Sensors that are widely used in various fields are required for medical use, even if the form is different, such as piezoelectric elements that use piezoelectric phenomena in sensors and electrostatic types that use capacitance change between electrodes. It can be used in such a way as to satisfy the conditions, and in this way, many pressure sensing element and displacement sensing element technologies can be used, and a highly reliable and suitable medical pressure sensor can be realized at low cost. can do.

  The pressure sensor as an embodiment of the present invention illustrated in FIGS. 4 and 5 is not limited to this. For example, the number of pressure detection elements arranged two-dimensionally is assumed to be m and n as integers. , M × n, and 5 × 9 or 9 × 15 pressure detectors or pressure detectors are arranged in an elliptical shape with a short axis of 1 cm and a long axis of 3 cm, for example, between the human ribs. This makes it possible to accurately measure the apical pulsation of a person with a conspicuous rib, and to enable many variations. The two-dimensional arrangement of the pressure detection element or pressure detection unit of the pressure sensor according to the present invention is not limited to the measurement of the pulsation diagram, but accurately detects the movement of the heart that performs complex movements including twisting movement. It can be grasped and has a great effect of enabling a correct diagnosis.

  FIGS. 6 to 9 simultaneously measured the apex rhythm diagram of the living body to be measured on the left side lying on the bed in a normal hospital room using the biological reaction recording apparatus as an embodiment of the present invention. It is an example of the heart machine diagram shown with the electrocardiogram, the heart sound diagram, and the first derivative curve of the apex rhythm diagram.

  6 to 9, reference numerals 500, 510, 520, and 530 are heart mechanisms, 502, 512, 522, and 532 are apex rhythms, 503, 513, 523, and 533 are heart sounds, and 504, 514, 524, and 534 Is the electrocardiogram, 501, 511, 521, 531 are the first derivative curves of the apex rhythm diagrams 502, 512, 522, 532, 5011 is the isovolumetric peak of the first derivative curve 501, and 5013 is the rapid inflow wave (3 Corresponding to the sound), the peak of the primary differential curve 501 corresponding to the left atrial contraction wave (corresponding to the four sounds), and 5111 the peak of the isovolumetric contraction of the primary differential curve 511. 5113 is almost unknown, but the peak of the first derivative curve 511 corresponding to the rapid inflow wave, and 5114 is the peak of the first derivative curve 511 corresponding to the left atrial contraction wave. 5211 is the peak of the isovolumetric contraction phase of the primary differential curve 521, 5213 is the peak of the primary differential curve 521 corresponding to the rapid inflow wave, 5214 is the peak of the primary differential curve 521 corresponding to the left atrial contraction wave, 5311 is The peak of the isobaric systole of the primary differential curve 531, 5313 is the peak of the primary differential curve 531 corresponding to the rapid inflow wave, 5314 is the peak of the primary differential curve 531 corresponding to the left atrial contraction wave, 5031, 5131, 5231, 5331 is one sound, 5032, 5132, 5232 and 5332 are two sounds, 5333 is a state where three and four sounds are superimposed, 5034 and 5134 are four sounds, and 5041, 5141, 5241 and 5341 are QRS waves.

  6 to 9, the horizontal axis is the time axis common to each graph (figure), and the numbers on the horizontal axis are point values when the start point (not shown) is 0 seconds and 10 seconds is 12000 points. The vertical axis is a standard value of amplitude (intensity), and the relative value indicating the standard of detection intensity for electrocardiograms and electrocardiograms, and the maximum value for 10 seconds normalized to 1000 for apex rhythms The numerical value and the first derivative curve are differentiated values.

  One of the features of the graph of FIG. 6 is that the first derivative curve peak 5011 corresponding to the isovolumetric systole is high and the first derivative curve peak 5013 corresponding to the rapid inflow wave is low, corresponding to the left atrial contraction wave. The peak 5014 of the first derivative curve is low.

  One of the features of the graph of FIG. 7 is that the peak 5111 of the first derivative curve corresponding to the isovolumetric systole is high, and the peak 5113 of the first derivative curve corresponding to the rapid inflow wave is hardly understood. That is, the peak 5114 of the primary differential curve corresponding to is about 40% of the peak 5111.

  One of the characteristics of the graph of FIG. 8 is that the peak 5213 of the first derivative curve corresponding to the rapid inflow wave and the peak 5214 of the first derivative curve corresponding to the left atrial contraction wave are more than the peak 5211 corresponding to the isovolumetric systole. It is expensive.

  One of the features of the graph of FIG. 9 is that the peak 5313 of the primary differential curve corresponding to the rapid inflow wave is higher than the peak 5311 corresponding to the isovolumetric systole, and the peak of the primary differential curve corresponding to the left atrial contraction wave. 5314 is not higher than the peak 5311 corresponding to the isovolumetric systole, but about half of it. When it becomes severe, the left atrial contraction wave becomes inconspicuous and becomes a rapid inflow wave only.

  FIG. 6 shows a case of a healthy person capable of intense sports, FIG. 7 shows a case of a patient with normal left ventricular contraction but impaired expansion, and FIG. FIG. 9 in the case of a patient who has a patient is an example of a severe patient, and the data in the case of a patient who cannot move even worse than the case of FIG. More specifically, FIG. 7 shows data of a patient who cannot perform intense sports but can go up and down stairs, go out and travel, and FIG. 8 shows data of a patient who can walk only slowly. Is the data of patients who cannot walk without leaving the bed to the toilet.

  FIGS. 10 to 16 are diagrams for explaining examples of temporal changes in heartbeat diagrams measured using a biological reaction recording apparatus as an embodiment of the present invention. FIGS. FIGS. 13, 13 and 14 are heart diagrams of the same measured living body different from the measured living body of FIGS. 10 to 12, and FIGS. 15 and 16 are measured living bodies of FIGS. 10 to 12 and FIGS. It is a heartbeat figure of the same to-be-measured living body different from FIG.

  10 to 16, reference numerals 554, 558, 562, 566, 570, 574, 578 are electrocardiograms, 553, 557, 561, 565, 569, 573, 577 are electrocardiograms, 552, 556, 560, 564, 568. , 572, 576 are apex rhythm diagrams, 551, 555, 559, 563, 567, 571, 575 are primary differential curves of the apex rhythm diagrams, and A1 to A5 are A waves (left atrial contraction wave) of each apex rhythm diagram. ), 5511, 5551, 5591, 5631, and 5671 are the extreme values of the differential waveform in the isovolumetric contraction period, and 5514, 5554, 5594, 5634, and 5684 are the extreme values of the A wave.

  FIG. 10 is a heart diagram when the measured living body has a blood pressure of 230/130, and FIG. 11 is a heart mechanism diagram when the blood pressure is 200/110 by administering a hypotensive drug to the measured living body of FIG. FIG. 12 is a heartbeat diagram in a state in which the measured living body of FIG. 10 has a blood pressure of 160/90 due to treatment, and the medical condition has improved, and measurement after 8 days from the measurement of FIG. It is data.

  10 to 12, the A wave of the apex rhythm is clearly noticeable in FIG. 10, is lower than FIG. 10 in FIG. 11, and is hardly noticeable in FIG. This is a phenomenon suggesting that left ventricular diastolic dysfunction has improved. The fact that the blood pressure actually decreased from 230/130 to 200/110 and further to 160/90 as described above indicates that the load on the heart is reduced. The A wave indicated by reference numeral A3 is an example that is difficult to understand in FIG. 12, but it may be difficult to understand where to take. Even in such a case, if a differential waveform is used as shown in FIG.

  FIG. 13 is a heartbeat diagram in a state where the measured living body is bad, and FIG. 14 is a heartbeat diagram in a state where the medical condition of the measured biological body in FIG. 13 is improved as a result of treatment, and is measurement data 14 days after the measurement in FIG. . This is an example of a left ventricular diastolic disorder that can be said to be similar to FIGS. 10 to 12, and is a phenomenon suggesting that the diastolic dysfunction of the left ventricle is improved even if the A wave is reduced. In the blood pressure data, the blood pressure is lowered from 190/110 to 160/85 by administering a blood pressure lowering agent.

  10 to 12, with respect to extreme values (reference numeral 5511 in FIG. 10, reference numeral 5551 in FIG. 11, reference numeral 5591 in FIG. 12, reference numeral 5631 in FIG. 13, reference numeral 5671 in FIG. 14) with differential waveforms in the differential waveform. The left ventricular end-diastolic situation is grasped by looking at the ratio of the extreme values of the A wave (reference numeral 5514 in FIG. 10, reference numeral 5554 in FIG. 11, reference numeral 5594 in FIG. 12, reference numeral 5634 in FIG. 13, reference numeral 5574 in FIG. 14). it can. If the ratio of the extreme value of the A wave decreases, it is suggested that the load in the end diastole of the left ventricle is reduced.

  15 is a heart diagram in a state where the measured living body is in a bad state, and FIG. 16 is a heart mechanism diagram in a state where the measured biological body in FIG. 15 is improved as a result of treatment, and measurement data after about 6 months from the measurement in FIG. It is. Reference numerals d1 to d9, d31 to d3, and d91 are points for explaining examples of the characteristics of the primary differential waveform of the apex rhythm diagram.

  In any case, there is a characteristic in the temporal change of the peak shape of the pulsation chart, and in FIG. 15, considering the A wave, the d1 point of the differential waveform (the maximum point of the differential value) to the d2 point (The point where the differential value is approximately 0) (the differential value may fall from the d1 point to the d2 point and may rise again and then fall down to the d2 point) to the d3 point (minimum differential value point) It goes down in a straight line, then rises from d3 point to d31 point where the differential value is 0, and is almost horizontally from d31 point to d32 point (although there are some fluctuations due to noise and other circumstances, it is roughly horizontal) After a lapse, it goes from d32 point to d33 point (point corresponding to d1 point of the next cycle) and then repeats this. In FIG. 16, from d4 point (maximum point of differential value) to d5 Until the point (the point where the differential value is almost 0) After moving down linearly and moving horizontally until d6 point, after moving down linearly from d6 point to d7 point (minimum differential value), it is generally d8 point (point where the differential value is almost 0). It moves linearly (the differential value goes up and down after the point of 0, but it is a fine change, it can be said that it is almost linear) and moves to the d9 point after that and moves almost horizontally to the d91 point (next cycle) (Which corresponds to d4 point) and then repeat this process.

  15 shows an example of a heart failure state in which the left ventricular contractility (left ventricular ejection fraction) is 40%, and FIG. 16 shows a left ventricular ejection fraction when a heart failure therapeutic agent is administered to the patient in the state of FIG. This is an example in which the state is improved to 60%.

  17, 18 and 19 are diagrams for explaining an example of the pulsation amplitude distribution as an embodiment of the present invention. FIG. 17 is a diagram for explaining the pressure detection position of the pressure sensor. P1 to P9 are pressures. 18 and 19 are diagrams showing examples of typical patterns of the pulsation amplitude distribution measured by the pressure sensor shown in FIG. 17 as cross-sectional views at predetermined positions of a three-dimensional display figure. is there. 18 and 19, the horizontal axis of each figure (graph) indicates the pressure detection position of FIG. 17, and the vertical axis indicates the magnitude of the pulsation amplitude at each pressure detection position indicated on the horizontal axis. It is shown as data.

  As a typical pattern of the pulsation amplitude distribution, at least the type shown in FIG. 18A (hereinafter also referred to as pattern A) at the positions of the pressure detection positions P4, P5, and P6 in FIG. There are types shown in B) (hereinafter also referred to as pattern B).

  More specifically, when apex pulsation is measured with a pressure sensor in which a large number of pressure detection elements or pressure detection units are arranged at positions indicated by P1 to P9 in FIG. As shown in FIG. 19, the amplitude distribution at the pressure detection positions P1 to P3, P4 to P6, and P7 to P9 shown in FIG. As shown in FIG. 17, the amplitude distribution at the pressure detection positions P1 to P3 and P7 to P9 in FIG. 17 is different from the amplitude distribution at P4 to P6, and the amplitude at the pressure detection position P5 in FIG. , P4, P6, and P8 are smaller than the amplitude at the pressure detection position P5 but larger than the amplitudes at the pressure detection positions P1, P3, P7, and P9.

  The amplitude distribution of the pulsation of the measurement subject whose heart condition is not healthy has many patterns A, and the amplitude distribution of the pulsation of the measurement subject whose heart condition is normal has many patterns B. However, depending on the medical condition, the amplitude distribution of pattern B may be exhibited even in the case of a non-healthy person. In such a case, a correct diagnosis can be performed by combining the apex pulsation diagram, blood pressure, and the amplitude distribution of pulsations. As is clear from this example, the actual medical condition is qualified by diagnosing the measurement data of only the electrocardiogram, electrocardiogram, and apex rhythm with the measurement data of the pulsation amplitude distribution and intensity distribution. Can be diagnosed.

  The pulsation amplitude distribution shown in FIGS. 18 and 19 is data at a certain moment. In particular, the maximum amplitude in the case of pattern B (the amplitude at the pressure detection position P5 in FIG. 19) moves from P5 to another position during one beat.

  Furthermore, the detection of the intensity of the pulsation in the present invention is information that helps to estimate the momentum of the heart.

  As described above, the first-order differential waveform of the apex rhythm diagram, that is, the first-order differential waveform of the time-beat waveform can be used for feature extraction related to the pulsation of the living body to be measured. The differential waveform can be used for extracting feature points of the primary differential waveform of the apex rhythm diagram. In the utilization of the heart machine diagram for diagnosis, not only the waveform of the apical pulsation as data synchronized with the electrocardiogram or electrocardiogram, but also the use of the first and second derivatives, and the amplitude and amplitude of the pulsation The use of information on distribution, intensity, and intensity distribution is extremely important for accurate diagnosis.

  Regarding the grasp of the heart movement, it can be mentioned that the pulsation chart and the amplitude of the pulsation and the distribution of the amplitude can be known, but in addition to this, for example, whether the heart is moving vigorously or moving strongly It is possible to know the intensity and intensity distribution. As is well known to doctors who perform palpation, the heart moves in a complex manner. Being able to be detected by a pressure sensor is important information for accurate diagnosis.

  The said Example can be utilized variously as needed, and can exhibit the effect which was not expectable conventionally.

  For example, after measuring the cardiac diagram, the results can be immediately explained to the patient, or the cardiac diagram can be shown to the patient and explained. Furthermore, the apparatus of the present invention includes, as one of reference data, past data of a measured living body, statistical data useful for diagnosis of the measured living body, and the like. It is possible to grasp the change of the above, or to explain to the living body to be measured for effective health management.

  An electrode for electrocardiogram measurement may be incorporated into the pressure sensor, and a microphone for electrocardiogram measurement may be incorporated into the pressure sensor. By configuring in this way, it is possible not only to enable high accuracy, simplification, miniaturization, price reduction, etc. of the recording apparatus, but also to measure by attaching many sensors to the measurement subject. Can greatly reduce the mental burden caused by.

  By forming the pressure sensor in a three-dimensional configuration, pressure and heart sounds can be detected, and the S / N ratio of measurement data can be increased.

  A transmitter or a transmitter / receiver is incorporated in the pressure sensor having various configurations as described above and attached to the living body to be measured, or a pressure sensor and a small and light transmitter or transmitter / receiver are attached to the living body to be measured. The device of the present invention is configured by transmitting or transmitting / receiving data measured by a sensor to an external device carried by a living organism or an external device located away from the living organism to be measured for health management by the measuring organism itself It can be used, or a medical professional can diagnose and measure the health of a living body.

  In the above example, the apex pulsation diagram has been described as an example of the pulsation diagram, but as described above, the present invention is not limited to the apex pulsation diagram, and the same applies to the various pulsations. It has a great effect.

  In the measurement of the electrocardiogram, even if the electrocardiogram and electrocardiogram sensors are provided in the apparatus of the present invention, the electrocardiogram and electrocardiogram data are measured separately from the apparatus of the present invention and input to the apparatus of the present invention. Even in this case, it is important to synchronize the pulsatogram with at least one of the electrocardiogram and the electrocardiogram. In this way, diagnosis can be performed with high reliability.

  As explained above, the chest and abdominal organisms that had to be recorded by a minimum of two doctors or doctors and technicians using a large-scale measurement facility and having a patient enter a special measurement room such as a soundproof room. According to the present invention, a response record can be measured in an outpatient office or hospital room of a hospital, and can also be recorded by a single doctor, and the data is recorded in a computer memory or the like. It can be played back as a moving picture on the spot from the data recorded in the. In other words, the present invention has a great effect as a medical treatment that can be fed back to the patient on the spot, and the satisfaction of the patient is increased. Examinations are also possible, and the quality of examination skills, such as visual inspection, palpation, and auscultation, is improved, and it is possible to make an accurate diagnosis of cardiovascular diseases.

  It is also extremely effective for lifelong education of doctors and clinical medical education for medical students and trainees.

  Furthermore, the present invention enables wide application of medical expertise such as normal health management and remote health management.

  The embodiment of the electronic component according to the present invention has been described with reference to the embodiments. However, the present invention is not limited to the embodiments, and many variations using the technical idea of the present invention are described. Is possible.

  As described above, according to the present invention, a pulsation diagram relating to the chest and abdomen, which is extremely important in clinical practice of the circulatory system but is actually difficult and has not been accurately measured and recorded, can be obtained with considerably high accuracy. It can be measured and recorded, and can be fed back to medical care on the spot or used as past data, for example.

  The present invention significantly improves the medical care level of the circulatory system, enhances the cooperation effect with other medical fields, contributes greatly to the development of medicine, greatly contributes to the saving of medical expenses, etc. It has a great economic effect and is widely used in the medical field and medical education field.

It is a figure explaining the biological reaction recording device as an example of an embodiment of the invention. It is a block diagram explaining the biological reaction recording device which can also perform remote management as an embodiment of the present invention as an embodiment of the present invention. It is a block diagram explaining the example of the measurement data process in the biological reaction recording device as an embodiment of this invention. It is a figure explaining the pressure sensor as an example of an embodiment of the invention. It is a figure explaining the pressure sensor as an example of an embodiment of the invention. It is the example of the heart figure measured with the biological reaction recording device as an embodiment of the present invention. It is the example of the heart figure measured with the biological reaction recording device as an embodiment of the present invention. It is the example of the heart figure measured with the biological reaction recording device as an embodiment of the present invention. It is the example of the heart figure measured with the biological reaction recording device as an embodiment of the present invention. It is a figure explaining the example of the time change of the cardiac figure measured with the biological reaction recording device as an example of embodiment of this invention. It is a figure explaining the example of the time change of the cardiac figure measured with the biological reaction recording device as an example of embodiment of this invention. It is a figure explaining the example of the time change of the cardiac figure measured with the biological reaction recording device as an example of embodiment of this invention. It is a figure explaining the example of the time change of the cardiac figure measured with the biological reaction recording device as an example of embodiment of this invention. It is a figure explaining the example of the time change of the cardiac figure measured with the biological reaction recording device as an example of embodiment of this invention. It is a figure explaining the example of the time change of the cardiac figure measured with the biological reaction recording device as an example of embodiment of this invention. It is a figure explaining the example of the time change of the cardiac figure measured with the biological reaction recording device as an example of embodiment of this invention. It is a figure explaining the pressure detection position of the pressure sensor in the biological reaction recording device as an embodiment of the present invention. It is a figure explaining the example of the amplitude distribution of the pulsation measured with the biological reaction recording device as an example of an embodiment of the invention, and is the figure shown as a sectional view in the predetermined position of the figure of three-dimensional display. It is a figure explaining the example of the amplitude distribution of the pulsation measured with the biological reaction recording device as an example of an embodiment of the invention, and is the figure shown as a sectional view in the predetermined position of the figure of three-dimensional display. It is a photograph of a conventional heart mechanism diagram recording apparatus main body. It is a photograph of the example of various conventional transducers. It is a perspective view of the conventional biological sound detection apparatus. It is sectional drawing of the biological sound detection apparatus of FIG. FIG. 21 is a perspective view of a pulsation diagram measuring transducer of the heartbeat diagram recording apparatus of FIG. 20. FIG. 21 is a perspective view of a transducer for measuring a heart sound diagram of the heartbeat diagram recording apparatus of FIG. 20. It is a photograph of a living body to be measured with a conventional apparatus. It is a heartbeat diagram obtained as a result of measurement by a conventional heartbeat diagram recording apparatus.

Explanation of symbols

40: Microphone 101, 502, 512, 522, 532, 552, 556, 560, 564, 568, 572, 576: Apical rhythm diagram 102, 103, 104, 553, 557, 561, 565, 569, 573, 577 : Electrocardiogram 105, 554, 558, 562, 566, 570, 574, 578: Electrocardiogram 110: Transducer for pulsatogram measurement 111: Pressure transmission part 112, 122: Case outer peripheral frame 113, 123: Case side surface 114, 124: Lead wire 120: Transducer for heart sound diagram measurement 121: Heart sound measurement unit 200: Biological reaction recording device 201, 201a, 201b, 301: Pressure sensor 202, 305a: Heart sound sensor 203: Electrocardiogram sensor 211, 212, 213 , 231, 241: wiring 220, 3 20: Control / measurement data processing unit 230, 330: Storage unit 240, 340: Display unit 241a to 241c, 242a to 242c, 243a to 243c, 244a to 244d, 251a to 251c, 252a to 252c, 253a to 253c: Pressure sensor 245: Inner wall of the outer peripheral portion of the pressure sensor 246, 255: Outer wall of the outer peripheral portion of the pressure sensor 247: Space portion 248, 258: Substrate 271 to 287: Reference numeral 300 for explaining processing steps, processing contents, functions, etc. Biological reaction recording system 305b: Sensors 311, 315a, 315b, 331, 341, 351: Contact means 350: Remote management unit 500, 510, 520, 530: Heartbeat diagram 501, 511, 521, 531, 551, 555, 559, 563, 567, 571, 575: cardiac apex Primary differential curves 503,513,523,533: electrocardiogram 504,514,524,534: electrocardiogram 5011,5013,5014,5111,5113,5114,5211,5213,5214,5311,5313,5314: apex Peak of first-order differential curve of pulsation diagram 5031, 5131, 5231, 5331: 1 sound 5032, 5132, 5232, 5332: 2 sounds 5333: State where 3 sounds and 4 sounds are superimposed 5034, 5134: 4 sounds 5041, 5141 5241, 5341: QRS wave 5511, 5551, 5591, 5631, 5671: Extreme value of differential waveform in isovolumetric systole 5514, 5554, 5594, 5634, 5684: Extreme value of A wave A1-A5: Each apex pulse A wave (left atrial contraction wave)
d1 to d9, d31 to d3, d91: Points for explaining examples of features of the differential waveform of the apex rhythm diagram P1 to P9: Symbols indicating pressure detection positions

Claims (69)

  Heart beat or ascending aorta beat or pulmonary artery (including at least one of pulmonary trunk and central pulmonary artery) as at least one kind of pulsatile heartbeat, right ventricular beat and left atrial beat Alternatively, it is a novel biological reaction recording apparatus capable of detecting and recording at least one of abdominal aorta pulsation or liver pulsation as a measurement result of pressure change, wherein the biological reaction recording apparatus includes at least one of the Detecting biological reaction information (hereinafter also referred to as biological information) based on a pressure sensor capable of measuring the movement of a pulsation detection site as a pressure change, amplification means such as a measured signal, and measured data Data processing means such as an arithmetic processing unit, at least a main part of measured data, and biological information detected using the data processing means or data processing means Data processed in this way or data in the middle of processing (hereinafter referred to as biological data detected using the data processing means, data processed using the data processing means or data in the middle of processing as detected data) The pressure sensor measures the pressure at a plurality of locations adjacent to the living body with respect to the one pulsation to be measured. The biological response recording apparatus characterized in that the storage means can store at least one of the measurement data at the plurality of locations and at least one of the detection data.   2. The biological reaction recording apparatus according to claim 1, wherein the biological reaction recording apparatus stores the detection data (hereinafter, also referred to as a time-dependent change of the detection data) measured at a plurality of different times of the same living body to be measured. A biological reaction recording apparatus characterized by being capable of performing.   3. The biological reaction recording apparatus according to claim 1, wherein the biological reaction recording apparatus includes an electrocardiogram measurement sensor and an electrocardiogram measurement sensor.   The biological reaction recording device according to any one of claims 1 to 3, wherein the biological reaction recording device inputs data of at least one of an electrocardiogram and a heart sound diagram of a living body to be measured from the outside of the biological reaction recording device. And a biological reaction recording apparatus characterized by being capable of synchronizing with at least one of the data.   The biological reaction recording device according to any one of claims 1 to 4, wherein the biological reaction recording device includes means for selecting an extreme value of processed data such as the measurement data and detection data, and the periphery of the extreme value. A biological reaction recording apparatus comprising means for selecting data.   6. The biological reaction recording apparatus according to claim 1, wherein diagnostic information relating to a health condition of the living body can be displayed on the display means.   The biological reaction recording device according to any one of claims 1 to 6, wherein the display means displays the diagnostic information with a health level such as health, caution 1, caution 2, and danger. Biological reaction recording device characterized by being capable of   8. The biological reaction recording apparatus according to claim 6 or 7, wherein the diagnostic information relating to the health state of the living body includes an electrocardiogram, a heart sound diagram, and a pulsation diagram, and further includes first-order differential data obtained by differentiating a time-beat waveform with respect to time. A biological reaction recording apparatus characterized by being information including at least one of secondary differential data obtained by differentiating primary differential data with respect to time.   The biological reaction recording device according to any one of claims 1 to 8, wherein an electrocardiogram, a phonocardiogram, and a pulsation diagram of the living body can be displayed on the display means, and a time-pulsation waveform is expressed in time. A biological reaction recording apparatus capable of displaying at least one of differentiated primary differential data and secondary differential data obtained by differentiating the primary differential data with respect to time.   The biological reaction recording device according to claim 1, wherein the biological reaction recording device has means for detecting and displaying at least one of pulsation amplitude and amplitude distribution. Biological reaction recording device.   11. The biological reaction recording apparatus according to claim 10, wherein a temporal change of at least one of the amplitude of the pulsation and the amplitude distribution can be displayed.   12. The biological reaction recording apparatus according to claim 1, wherein the biological reaction recording apparatus has means for detecting and displaying at least one of pulsation intensity and intensity distribution. Biological reaction recording device.   The biological reaction recording apparatus according to claim 12, wherein the temporal change of at least one of the pulsation intensity and the intensity distribution can be displayed.   The biological reaction recording apparatus according to claim 10, wherein the pulsation amplitude or intensity distribution can be displayed as a three-dimensional figure.   15. The biological reaction recording apparatus according to claim 14, wherein the pulsation amplitude or intensity distribution can be displayed as a cross-sectional view at a predetermined position of the three-dimensional figure.   16. The biological reaction recording apparatus according to claim 1, wherein the pulsation detection site is a chest.   The biological reaction recording device according to claim 1, wherein the pulsation detection site is an abdomen.   The biological reaction recording device according to any one of claims 1 to 17, wherein the biological reaction recording device includes past data storage means for storing past data of the same measured living body, and health of the living body. A biological reaction recording apparatus capable of displaying a change in diagnostic information of a state.   The biological reaction recording device according to any one of claims 1 to 18, wherein the biological reaction recording device has statistical data storage means for storing statistical data of at least one of the same living body and a plurality of living bodies. A biological reaction recording device.   The biological reaction recording device according to claim 1, wherein the biological reaction recording device is a device capable of performing transmission / reception with another device.   21. The biological reaction recording device according to claim 20, wherein the biological reaction recording device is a device capable of transmitting and receiving with a telemedicine system and managing a health condition of a living body to be measured. apparatus.   The biological reaction recording device according to claim 20 or 21, wherein the biological reaction recording device is a device capable of performing transmission / reception with another device, and at least a pressure is applied to a portion of the device attached to a measurement subject. A biological reaction recording apparatus comprising a sensor.   23. The biological reaction recording apparatus according to claim 1, wherein the pressure sensor includes a plurality of pressure detection units (also referred to as pressure sensor units) or a plurality of pressure detection elements arranged two-dimensionally. Biological reaction recording device, characterized in that it is a two-dimensional pressure sensor.   The biological reaction recording apparatus according to any one of claims 1 to 23, wherein the pressure sensor is a two-dimensional pressure sensor in which a plurality of pressure detection units or a plurality of pressure detection elements are arranged concentrically. A biological reaction recording device characterized by the above.   The biological reaction recording device according to any one of claims 1 to 24, wherein the pressure sensor is a two-dimensional pressure sensor in which a plurality of pressure detection units or a plurality of pressure detection elements are arranged radially. A biological reaction recording device.   The biological reaction recording device according to any one of claims 1 to 25, wherein the pressure sensor includes at least three pressure detection elements or two pressure detection elements or two pressure detection elements in two directions orthogonal to each other. A biological reaction recording apparatus comprising a two-dimensional pressure sensor having a pressure detection unit.   The biological reaction recording device according to any one of claims 1 to 26, wherein the pressure sensor is a pressure sensor configured by two-dimensionally arranging a plurality of pressure detection elements on a support substrate. Biological reaction recording device.   The biological reaction recording device according to any one of claims 1 to 27, further comprising at least one three-dimensional pressure sensor as the pressure sensor.   29. The biological reaction recording apparatus according to any one of claims 1 to 28, wherein the pressure sensor is a pressure transmission unit between a portion of the living body to be measured that is in contact with a surface of the measurement target and a pressure detection unit of the pressure sensor. The living body reaction recording apparatus according to claim 1, wherein an area of a portion of the cross section of the pressure transmitting portion that abuts on the surface of the measured portion is larger than an area on the pressure detecting portion side.   30. The biological reaction recording apparatus according to claim 1, wherein the pressure detection unit of the pressure sensor is a pressure detection unit using a piezoelectric effect (hereinafter referred to as a piezoelectric pressure sensor or a piezo pressure sensor). Biological reaction recording device characterized by the above.   31. The biological reaction recording apparatus according to claim 30, wherein the pressure sensor is a piezo pressure sensor using a semiconductor.   The biological reaction recording apparatus according to any one of claims 1 to 31, wherein the pressure sensor is a pressure sensor that uses a change in capacitance as a pressure sensor (hereinafter referred to as a capacitance type). A biological reaction recording apparatus comprising a pressure sensor).   33. The biological reaction recording apparatus according to claim 32, wherein the pressure sensor is a pressure sensor formed using a semiconductor.   The biological reaction recording device according to any one of claims 23 to 33, wherein the pressure detection unit or the pressure transmission unit of the pressure sensor is arranged in a region where the outer periphery is generally a circle. Reaction recording device.   The biological reaction recording device according to any one of claims 23 to 33, wherein the pressure detection part or the pressure transmission part of the pressure sensor is arranged in a region where the outer periphery is generally a polygon having a quadrangle or more. A biological reaction recording device.   The biological reaction recording device according to any one of claims 1 to 35, wherein an outer shape of the exterior body on which the pressure sensor is mounted is a round shape such as a substantially circular shape or an oval shape. A biological reaction recording device.   37. The biological reaction recording apparatus according to claim 1, wherein the pressure detectable range of the pressure sensor is a range in which a circumscribed circle has a diameter of 30 mm or more.   38. The biological reaction recording apparatus according to claim 37, wherein a pressure detectable range of the pressure sensor is a range in which a circumscribed circle has a diameter of 40 mm or more.   The biological reaction recording device according to any one of claims 1 to 38, wherein the shape of at least a portion of the pressure sensor that comes into contact with the measured living body is deformable. Recording device.   The biological reaction recording device according to any one of claims 1 to 39, wherein the biological reaction recording device is a contact pressure between the pressure sensor and a living body to be measured or at least two of the pressure sensors. A biological reaction recording apparatus comprising contact pressure detecting means capable of detecting at least one of a difference in contact pressure between a pressure detecting element or each pressure detecting portion and a living body to be measured.   41. The biological reaction recording apparatus according to claim 39 or 40, wherein the biological reaction recording apparatus has means for changing the contact pressure in response to the contact pressure detected by the contact pressure detecting means. Biological reaction recording device.   The biological reaction recording device according to any one of claims 1 to 41, wherein the biological reaction recording device puts the pressure sensor in a state in which the measurement can be performed at a measurement portion of the biological body to be measured. A biological reaction recording device comprising means for mounting.   43. The biological reaction recording apparatus according to claim 42, wherein the means for attaching the pressure sensor to the measurement subject is a means using suction force.   44. The biological reaction recording apparatus according to claim 42 or 43, wherein the means for attaching the pressure sensor to the living body to be measured is a means using adhesive force.   45. The biological reaction recording device according to any one of claims 1 to 44, wherein the biological reaction recording device receives at least one of the measurement data, the detection data, and the diagnostic information of the health state of a living body as a still image and a moving image. A biological reaction recording apparatus, which is a recording apparatus capable of presenting at least one of them in real time.   The biological reaction recording device according to any one of claims 1 to 45, wherein at least a part of the measured data and the detected data is normalized data. apparatus.   The biological reaction recording device according to any one of claims 1 to 46, wherein the biological reaction recording device displays at least one pulsation diagram among the pulsation diagrams as the detection data. A biological reaction recording apparatus characterized by being capable of performing.   48. The biological reaction recording apparatus according to claim 47, wherein the biological reaction recording apparatus is capable of displaying an electrocardiogram and an electrocardiogram as the detection data.   49. The biological reaction recording apparatus according to any one of claims 1 to 48, wherein the biological reaction recording apparatus includes sampling means for sampling at least one of measurement data of the sensor and detection data. The biological reaction recording device characterized by the above-mentioned.   The biological reaction recording device according to any one of claims 1 to 49, wherein the biological reaction recording device removes noise from at least one of processing data such as measurement data of the sensor and detection data. A biological reaction recording apparatus comprising a removal unit.   The biological reaction recording device according to any one of claims 1 to 50, wherein the biological reaction recording device sets at least one of a data processing condition, a sampling condition, and a noise removal condition to the biological reaction recording apparatus. A biological reaction recording apparatus comprising condition changing means that can be changed by a user.   52. In the biological reaction recording device according to claim 1, in the signal processing of the data measured as the pressure change of the movement of at least one of the pulsation detection sites, the measurement data of the pressure sensor is used. Using the filter cutoff frequency or time constant of the signal processing circuit to be processed as a parameter (hereinafter also referred to as parameter 1), the measurement data of the same or the same type of pressure sensor with different values of the parameter 1 A biological reaction recording apparatus characterized in that the result of performing the signal processing is used as diagnostic information on the health state of the living body.   53. The living body reaction recording apparatus according to any one of claims 10 to 52, wherein an area to be measured of a living body when detecting and displaying one or both of the amplitude distribution and the intensity distribution of the pulsation has at least a diameter. A biological reaction recording device having a circular range of 5 mm.   The biological reaction recording device according to any one of claims 1 to 53, wherein the biological reaction recording device has data (hereinafter also referred to as reference data) to be compared with the detection data. And means for comparing the reference data with the biological reaction recording apparatus.   55. The biological reaction recording apparatus according to claim 54, wherein the biological reaction recording apparatus has at least one of means for changing the reference data and means for adding.   56. The biological reaction recording apparatus according to claim 54 or 55, wherein the means for comparing the detected data with the reference data is means for detecting and displaying a difference between the detected data and the reference data. apparatus.   57. The biological reaction recording apparatus according to claim 54, wherein the reference data includes data using an extreme value of data.   The biological reaction recording device according to any one of claims 1 to 57, wherein the biological reaction recording device includes a pattern matching diagnostic unit that generates diagnostic information using a pattern matching technique. Recording device.   59. The biological reaction recording device according to any one of claims 1 to 58, wherein the biological reaction recording device measures a pulsation diagram by using an area between a time-beat waveform of a pulsation diagram and a time axis. A biological reaction recording apparatus comprising means for setting conditions.   Heart beat or ascending aorta beat or pulmonary artery (including at least one of pulmonary trunk and central pulmonary artery) as at least one kind of pulsatile heartbeat, right ventricular beat and left atrial beat Alternatively, it is a novel biological reaction recording apparatus capable of detecting and recording at least one of abdominal aorta pulsation or liver pulsation as a measurement result of pressure change, wherein the biological reaction recording apparatus includes at least one of the Detecting biological reaction information (hereinafter also referred to as biological information) based on a pressure sensor capable of measuring the movement of a pulsation detection site as a pressure change, amplification means such as a measured signal, and measured data Data processing means such as an arithmetic processing unit, at least a main part of measured data, and biological information detected using the data processing means or data processing means Data processed in this way or data in the middle of processing (hereinafter referred to as biological data detected using the data processing means, data processed using the data processing means or data in the middle of processing as detected data) The storage means can store at least one of the measurement data, and the storage means can store at least one of the measurement data and at least one of the detection data. A biological reaction recording apparatus capable of storing a plurality of the detection data (hereinafter also referred to as a change with time of detection data) measured at different times of the same living body to be measured.   61. The biological reaction recording apparatus according to claim 60, wherein the biological reaction recording apparatus includes an electrocardiogram measurement sensor and an electrocardiogram measurement sensor.   The biological reaction recording device according to claim 60 or 61, wherein the biological reaction recording device can input data of at least one of an electrocardiogram and a heart sound diagram of a living body to be measured from outside the biological reaction recording device. A biological reaction recording apparatus characterized in that it can be synchronized with at least one of the data.   Heart beat or ascending aorta beat or pulmonary artery (including at least one of pulmonary trunk and central pulmonary artery) as at least one kind of pulsatile heartbeat, right ventricular beat and left atrial beat Alternatively, it is a novel biological reaction recording method capable of detecting and recording at least one of abdominal aorta pulsation or liver pulsation as a measurement result of pressure change, and the biological reaction recording method includes at least one of the above-mentioned biological reaction recording methods A pressure sensor that can measure the movement of the pulsation detection site as a pressure change at a plurality of locations in the vicinity of the measurement site is used, and is measured as a pressure change by the pressure sensor of at least one of the pulsation detection site movements. Means for detecting biological reaction information (hereinafter also referred to as biological information) from stored data, means for storing the detected biological information, and the detection Biological response recording method characterized by using the means for displaying the diagnostic information on the state of health of the living body based on the biological information.   64. The biological reaction recording method according to claim 63, wherein at least one of the electrocardiogram and electrocardiogram data of the measured living body can be input from outside the biological reaction recording apparatus, and at least one of claim 63. A biological reaction recording method characterized in that it can be synchronized with two data.   65. The biological reaction recording method according to claim 63 or 64, wherein the biological reaction recording method uses an electrocardiogram measurement sensor and a heart sound diagram measurement sensor.   The biological reaction recording method according to any one of claims 63 to 65, wherein at least one of the chest and abdomen is targeted as the pulsation detection region.   The biological reaction recording method according to any one of claims 63 to 66, wherein an electrocardiogram, a phonocardiogram, and a pulsation diagram are used as diagnostic information of the health state of the living body, and a time-pulsation waveform is differentiated by time. A biological reaction recording method using information including at least one of primary differential data and secondary differential data obtained by differentiating the primary differential data with respect to time.   The biological reaction recording method according to any one of claims 63 to 67, wherein means for detecting and displaying at least one of pulsation amplitude, amplitude distribution, intensity, and intensity distribution in the chest is used. A biological reaction recording method.   69. The biological reaction recording method according to any one of claims 63 to 68, wherein the biological reaction recording method uses means for comparing detection data detected from the measured data with reference data. Biological reaction recording method.

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