JP2015126890A - Vital reaction recording device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a vital reaction recording device by solving such problems that, while a medical value of a mechanocardiogram is admitted high, a mechanocardiogram recording device is large and extremely expensive and the measurement performance thereof is also poor, and at least two medical professionals are required and can perform measurement only in a specific environment such as a sound proof room, accordingly, effective data for a measured living body truly needing the diagnosis using the mechanocardiogram cannot be obtained, and thereby the mechanocardiogram recording device is considered not useful for the diagnosis of a circulatory system.SOLUTION: A vital reaction recording device can be provided that is inexpensive in a small size like a notebook-sized personal computer, in which a two-dimensional sensor capable of simultaneously measuring the pressure change in a plurality of positions adjacent to a living body with respect to one pulsation to be measured, an electronic device of a personal computer level and a memory are fully used, and an apex cardiogram is measured, and also the time elapse of the living body information is also stored and can be used, and the living body information can be displayed as a digital image.

Description

  The present invention can be used for diagnosing the state of the heart by measuring the movement of the heart and large blood vessels of the living body and the change in blood flow sent from the heart into the living body as changes in the chest and abdomen. More specifically, the reaction recording apparatus and the biological reaction recording method, and more specifically, at least one of the apex pulsation, the right ventricular pulsation and the left atrial pulsation of the living body without using a special measurement room such as a soundproof room. A change in the chest or abdomen of at least one of a pulsation, an ascending aorta pulsation, a pulmonary artery (including at least one of the pulmonary artery trunk and central pulmonary artery), an abdominal aorta pulsation, or a liver pulsation The present invention relates to a biological reaction recording apparatus and a biological reaction recording method that can be detected and recorded as measurement results, can be miniaturized, and can be realized as an inexpensive apparatus.

  The present invention is firstly applied to a case where the living body to be measured is a human being and exhibits a great effect, but can also be applied to cases where the living body to be measured is other than a human being.

  However, a particularly important purpose is utilization for human beings, and in the following description, the case where the living body to be measured is a human will be described as an example.

  In recent years, not only medicine itself but also medical development accompanying the progress of engineering is remarkable. This tendency is the same in the field of cardiovascular medicine. For example, the blood pressure measuring device has been remarkably advanced and popularized, and has been widely used by the general public regardless of the involvement of medical professionals.

  In hospitals and other places where medical professionals are deeply involved, a lot of data such as ankle blood pressure, upper limb blood pressure, carotid, femoral, popliteal, and limb peripheral arterial waves are collected. It is stored in a storage device and used for diagnosis.

  With regard to circulatory system measurements, practical recording devices that can be measured at the normal bedside have been developed without requiring a special environment such as a soundproof room except for the chest, abdomen, and neck (jugular vein). A lot of data has been taken and utilized, but with regard to the chest, abdomen and neck (jugular vein), at least two medical professionals were asked to have a subject enter a special measurement room such as a soundproof room. At present, the data is taken.

  Regarding visual inspection and palpation in circulatory system examination, jugular vein pulsation, carotid artery pulsation and apex pulsation are particularly important.

  Of these, carotid pulsation has already been measured and recorded as a carotid wave by a measuring instrument and can be used for diagnosis.

  However, as for the cardiac mechanism diagram other than the carotid artery pulsation, as described later, there is still no practical level measuring device.

  From the past, the electrocardiogram has been measured and recorded by the electrocardiogram recording device in a special measurement room such as a soundproof room (for example, Non-Patent Document 1: Actual electrocardiogram / cardiogram inspection, page 211). As can be seen from the description of Non-Patent Document 1, which will be described later, the recording of the conventional heartbeat diagram has a subject enter a special measurement room such as a soundproof room and lie down on the bed in a special environment. Using the set heartbeat diagram recording device, data is measured as a heartbeat diagram by at least two doctors or doctors and technicians and recorded on a paper medium.

  FIG. 48 is a photograph of the heartbeat diagram recording apparatus set outside the soundproof room described in the figure on page 212 of Non-Patent Document 1, and FIG. 49 is a diagram of various transducers described on page 212 of Non-Patent Document 1. It is a photograph of an example.

  The heartbeat diagram recording apparatus of FIG. 48 is described in Non-Patent Document 1 as MIC8800T type manufactured by F company, and is provided with a moving carriage under the apparatus, and the width is approximately 60 cm. It is a large one with a height of approximately 180 cm and a depth of approximately 80 cm. Although it is equipped with a caster for movement, it is a heavy device that is difficult to move alone. In the figure, the window visible on the right side of the main body recording device main body is a window for looking into the soundproof room containing the subject.

  And this device is not only large, but also very expensive.

  It is described in Non-Patent Document 1 that the transducer shown in FIG. 49C can record the apex rhythm and the phonocardiogram at the same time.

  FIG. 50 is a perspective view of the biological sound detection device described in FIG. 1 of Japanese Patent Laid-Open No. 2000-60845 (hereinafter referred to as Patent Document 1), and FIG. 51 is the biological sound detection device of FIG. The part indicated by the reference numeral 40 is referred to as a microphone, and the whole component in FIGS. 50 and 51 is referred to as a biological sound detection device).

  The biological sound detection device of FIG. 50 and FIG. 51 is to record a heart sound by detecting a heart sound with a microphone mounted on the skin of the subject, so that the heart sound can be detected as accurately and with high sensitivity as possible. Various devices have been devised to reduce the influence of environmental noise such as speech, footsteps, and door opening / closing sounds generated from people other than the subject.

  As a device for reducing the influence of environmental noise, in FIG. 51, an air chamber 66 (64 in FIG. 51, which may be a mistake in 66), a vibration absorber, between the housing 22 and the microphone 40. 64 and 28, vibration absorbing sheet 46, weight 60, and the like, which suppress the influence of environmental noise. Further, in order to enhance the body sound detection effect, a tapered sound collection hole having a diameter decreasing from the skin side of the living body to the microphone side is provided between the microphone 40 and the body skin 11. It can be said that these represent the difficulty of measuring heart sounds.

  The heart sound detection apparatus described in Patent Document 1 shown in FIG. 50 and FIG. 51 is different from the pressure sensor for measuring the pulsation diagram of the present invention, but the transducer shown in FIG. Based on the fact that Non-Patent Document 1 describes that a motion diagram and a heart sound diagram can be recorded at the same time, it is cited above to refer to the fact that many measures are required in heart sound measurement.

  52 and 53 are perspective views of sensors actually used in a conventional heartbeat recording apparatus MIC9800 type. FIG. 52 shows a transducer for measuring a heart sound diagram, and FIG. 53 shows a transducer for measuring a pulsation diagram.

  52 and 53, reference numeral 110 is a pulsation diagram measurement transducer, 120 is a heart sound diagram measurement transducer, 111 is a pressure transmission unit, 121 is a heart sound measurement unit, 112 is a case outer peripheral frame, and 113 and 123 are case cases. Side surfaces 114 and 124 are lead wires.

  In the pulsation diagram measurement transducer 110, the pressure transmission part 111 is made of a hard material such as ceramic, is separated from the case outer peripheral frame 112, and moves slightly when pushed inward from the outside in the figure. It has become. When the transducer 110 is applied to the skin of the subject's pulsation measurement site, the pulsation is transmitted as a pressure change through the pressure transmission unit 111 to a pressure sensor (not shown) connected thereto and converted into an electrical signal. Then, it is inputted from the lead wire 114 to the MIC9800 type heartbeat diagram recording apparatus (not shown).

  The heart sound is measured by pressing the transducer 120 for measuring the heart sound against the skin of the subject's heart sound measurement location, and the heart sound is input from the lead wire 124 to the cardiac device recording device, and the heart sound is measured.

  The outer peripheral frame 112 of the transducer 110 has a cylindrical outer periphery with a diameter of 30 mm, and the pressure transmission unit 111 is disposed inside the outer peripheral frame 112. The portion visible inside the outer peripheral frame is a circular outer periphery with a diameter of 20 mm. The weight of the transducer 110 measured with the influence of the lead wire minimized is 19 g.

  A case outer peripheral frame 122 of the transducer 120 has a cylindrical outer periphery, a diameter of 25 mm, and the weight of the transducer 120 measured with a minimum influence of the lead wire is 34 g.

  The transducer 110 and the transducer 120 are attached to the subject's measurement site, and the respective lead wires are connected to the heartbeat diagram recording apparatus main body shown in FIG. 48 to measure pulsation and heart sound. Create a diagram.

  FIG. 54 is a diagram of the measurement of the cardiac rhythm described in the figure on page 222 of Non-Patent Document 1. In order to measure the cardiac rhythm, it enters the soundproof room and is placed on the left side on the bed, and the measurement microphone is attached to the chest. This is a photograph of a subject.

  This is because, in the photograph, the microphone lead wire is suspended from above, and otherwise environmental noise may be mixed.

In the vicinity of the cardiac device recording apparatus shown in FIG. 48, the measurer looks at the inside of the soundproof room from the window visible on the right side of the cardiac image recording apparatus, while using a microphone or the like other than the measurement terminal, You must measure the heartbeat diagram while communicating such as "hold your breath" or "exhale".

FIG. 55 is a heart diagram obtained as a result of the measurement. Reference numeral 101 is an apex rhythm diagram, 102 is a heart sound diagram (treble), 103 is a heart sound diagram (medium sound), 104 is a heart sound diagram (bass), and 105 is an electrocardiogram.

  In FIG. 55, since the subject is a young healthy person, three sounds appear in the phonocardiogram 104. This data can be said to be healthy person data.

  Although it is recognized by medical personnel that the heart diagram itself is necessary, as described in Non-Patent Document 1, measurement of the heart mechanism diagram is a very advanced technique and advanced as a specialist. It requires a lot of measurement ability and diagnostic ability and has many problems.

  First of all, it is necessary to put the subject in a special measurement room such as a soundproof room, so that the subject is limited to those who can withstand measurement in such an environment, Secondly, the measuring instrument is large and the measuring instrument is measured outside the soundproofing room in the soundproofing room, and a plurality of measurers are required. Third, the measurement is soundproofed and the room is limited like a closed room. The measurement is performed in a state different from the normal condition of the subject, and the subject is unnecessarily nervous. Fourth, the device is extremely expensive. And so on. For this reason, the conventional cardiac device recording apparatus has a great restriction on the selection of the subject, which places a heavy burden on the subject, is difficult to apply to severe patients who really want to diagnose, and the device is extremely expensive. In addition, the cost of collecting data such as the need for multiple medical professionals involved in measurement is high, the data recording is on paper and electronic recording of data is not possible, and data on critically ill patients cannot be obtained As a result, there are many problems such as the fact that the utility value of the data itself has become low, and it is hardly utilized in the medical field. It has been given up that a heartbeat recording device that can measure at the normal bedside cannot be realized.

  In this way, it is extremely difficult to measure the heartbeat diagram, the information obtained is insufficient, and the utility value is considered to be low, so the needs are not considered to be many in reality. Is considered to be unable to spend a great deal of money on the development of a cardiac chart recorder.

  On the other hand, the heart diagram itself is considered to have a high medical value, and if used correctly, it is thought to lead to a major advancement in medicine. Using an expensive and large cardiac recording device, the subject is asked to enter a special room like a soundproof room, measured by at least two medical professionals, and the results are announced. However, as described above, the research results and measurement data are not utilized at all in the medical field.

  This situation can also be understood by the low score for calculating the value of medical care at a medical institution. In other words, in the case of diagnosis using a conventional device to record a cardiac diagram, only a relatively low score is recognized as compared to the case of using other devices, and personnel costs and The actual situation is that the company will be in the red when the cost of the equipment is recovered. However, in this regard, as described above, the recording of the heart diagram using the conventional device is only data taken under very limited restrictions, and a patient who wants to make a real diagnosis from many experts. In view of the current situation in which it is considered impossible to use a heartbeat recording device, it is unavoidable.

  It has always been said that physical findings are important in medicine since ancient times.

  Tests for evaluating physical findings, particularly diagnostic imaging tests, have made great strides, and depending on the medical field, it has become possible to present pathological features in a simple, clear and objective manner. For this reason, there is a lot of reliance and expectation on these device diagnoses, and the physical findings that are difficult to display objectively, such as auscultation and auscultation, cannot be taken care of.

  It can be said that relying on easy and expensive equipment inspections as in the present situation without conducting appropriate inspections for correct medical care has led to a rise in medical costs.

  From these viewpoints and the viewpoint that communication between doctors and patients needs to be further enhanced, the importance of physical findings is screamed.

  On the other hand, the physical findings are subjective and lack objectivity. In medical education, it is important to teach the correct way of diagnosis, but there is a big problem in the current situation that the method has been carried out by each person.

With the background described above, the new development of cardiac device recorders is currently not very motivated by medical device manufacturers, but it can be said from the viewpoint of a doctor who truly understands this field. For example, in view of the current situation in which objective evaluation of auscultation and auscultation is not performed, if a small and inexpensive cardiograph recording device that can be measured at a normal bedside and can be objectively evaluated is realized, a circulatory organ We think that it brings big gospel to medical care of system.
Published by Japan Society for Clinical Hygiene and Examination: “Actual electrocardiogram and electrocardiographic examination” (published on November 1, 1996, 2nd edition), pages 212 and 222 Japanese Patent Laid-Open No. 2000-60845

  Regarding the cardiac diagram, although it is large at the research level as described above, many studies have been made and published by the medical doctor using a cardiac diagram recording device.

  However, as described above, in the conventional cardiac device recording apparatus, not only the measurement cost is high, but also effective data cannot be obtained for the patient who is really necessary for the diagnosis using the cardiac device diagram, and the diagnosis is made from the measured data. However, they had to rely on judgments made by experts with advanced knowledge of the world. Due to the lack of data, it is difficult for experts in this field to make an accurate diagnosis from measured data. Furthermore, since the detailed information on the heart itself cannot be grasped, the information on the heart movement is insufficient, and the cardiograph recording device was regarded as not useful for the diagnosis of the circulatory system. It can also be measured at the normal bedside, can grasp the temporal changes in cardiac function, and can be objectively evaluated to support palpation findings like the motion distribution of the heart itself. If a small and inexpensive cardiograph recording apparatus capable of obtaining necessary and sufficient information is realized, significant progress in cardiovascular medical care can be brought about.

  Recently, in order to improve such a situation, the inventor of the present invention, as a circulatory system examination, as at least one kind of pulsation of apex, right ventricular and left atrial beats. Detection of pressure change by pressure sensor, such as heartbeat, ascending aorta, pulmonary artery (including at least one of pulmonary artery trunk and central pulmonary artery), abdominal aorta or liver pulsation The measurement results can be recorded, and the measurement results can be recorded on the spot, and the patient's data can be evaluated and judged on the spot. And, from the viewpoint of medical education, it is possible to teach medical students and resident doctors the correct examination method (especially, regarding the examination palpation, the examination technique itself, the correct evaluation of the findings obtained by the examination) Biological response recording device, and biological response recording method can Unishi greatly improve clinical medical education Te was proposed to provide an inexpensive.

The present invention is a further improvement of the novel biological reaction recording apparatus proposed by the inventor of the present invention, and is constructed as a device that is easy to use in the medical field.
For example, if the position of the measurement microphone on the chest is not correct, the waveform will naturally change, but in addition to this, the waveform changes depending on the time constant set by the measurer in the data processing of the detected pressure sensor. It is not useful for diagnosis unless it is an apex rhythm diagram obtained by solving many problems.

  At present, there is no cardiograph recording device that can obtain a level of apical rhythm that can be measured at the bedside and used for diagnosis. In addition, it is extremely difficult to grasp changes over time in the heartbeat diagram with a conventional heartbeat diagram recording device, and it only captures the averaged movement of the heart, and palpation such as measuring the spread of the movement of the heart itself. Detailed information that can support the findings is not available.

  The remarkable feature of the technical idea of the present invention made to solve the above problems is that a pressure sensor is used for a chest, abdomen, etc. of a subject using a small, light and inexpensive device that can be easily carried by one person. The pressure change at a plurality of locations in the vicinity of the measurement location is recorded.

  Examples of the present invention will be specifically described below.

  A first invention as an example of the present invention made to solve the problem (hereinafter, also referred to as Invention 1) includes at least one of a cardiac apex beat, a right ventricular beat, and a left atrial beat. As a measurement result of pressure change, at least one of pulsation, ascending aorta pulsation, pulmonary artery (including at least one of pulmonary artery trunk and central pulmonary artery), abdominal aorta pulsation or liver pulsation A novel biological reaction recording device capable of detecting and recording, wherein the biological reaction recording device is measured as a pressure sensor capable of measuring the movement of at least one pulsation detection site as a pressure change. Data processing means such as an arithmetic processing unit capable of detecting biological reaction information (hereinafter also referred to as biological information) based on amplification means such as signals and measured data, and a small amount of measured data Data such as biological information detected using at least the main part and data processing means, information processed using the data processing means, or information in the middle of processing (hereinafter referred to as biological information detected using the data processing means or The pressure sensor has storage means and display means capable of storing at least one of data processed using the data processing means or data such as information in the middle of processing is also called detection data) Can measure the pressure at a plurality of locations adjacent to the living body with respect to one pulsation to be measured, and the storage means stores at least one of the measurement data at the plurality of locations and at least one of the detection data. It is a biological reaction recording device characterized by being able to perform.

  A second invention (hereinafter referred to as invention 2) as an example of the present invention developed from the invention 1 is the biological reaction recording apparatus according to the invention 1, wherein the biological reaction recording apparatus is the same subject to be measured. A biological reaction recording apparatus capable of storing the detection data measured at a plurality of different times (hereinafter also referred to as a change with time of detection data).

  A third invention (hereinafter referred to as invention 3) as an example of the present invention developed by developing the invention 1 or 2 is the biological reaction recording apparatus according to the invention 1 or 2, wherein the biological reaction recording apparatus is an electrocardiogram. A biological reaction recording apparatus having a measurement sensor and a phonocardiogram measurement sensor.

  A fourth invention (hereinafter referred to as invention 4) as an example of the present invention developed by developing the inventions 1-3 is the biological reaction recording device according to any one of the inventions 1-3, wherein the biological reaction recording is performed. A biological reaction recording apparatus characterized in that the apparatus can input at least one of electrocardiogram and electrocardiogram data of a living body to be measured from the outside of the biological reaction recording apparatus and can be synchronized with at least one of the data It is.

  A fifth invention (hereinafter referred to as invention 5) as an example of the present invention developed by developing the inventions 1 to 4 is the biological reaction recording device according to any one of the inventions 1 to 4, wherein the biological reaction recording is performed. The apparatus includes an extremum selection means for selecting an extremum of processed data such as the measurement data and the detection data, and a means for selecting extremum peripheral data for extremum peripheral data. It is a reaction recording device.

  A sixth invention (hereinafter referred to as invention 6) as an example of the present invention developed by developing the inventions 1 to 5 is the biological reaction recording apparatus according to any one of the inventions 1 to 5, wherein the display means includes A biological reaction recording apparatus capable of displaying diagnostic information relating to a health state of a living body.

  A seventh invention (hereinafter referred to as invention 7) as an example of the present invention developed from the inventions 1 to 6 is the biological reaction recording apparatus according to any one of the inventions 1 to 6, wherein the display means is used as the display means. The biological reaction recording apparatus is characterized in that the diagnostic information can be displayed with a health level such as health, caution 1, caution 2 and danger.

  An eighth invention (hereinafter referred to as invention 8) as an example of the present invention developed by developing the invention 6 or 7 is a diagnosis relating to the health condition of the living body in the biological reaction recording apparatus according to the invention 6 or 7. The information includes an electrocardiogram, a heart sound diagram, and a pulsation diagram, and further includes at least one of primary differential data obtained by differentiating a time-beat waveform with respect to time and secondary differential data obtained by differentiating the primary differential data with respect to time. This is a biological reaction recording apparatus.

  A ninth invention (hereinafter referred to as invention 9) as an example of the present invention developed from the inventions 1 to 8 is the biological reaction recording apparatus according to any one of the inventions 1 to 8, wherein the display means is used as the display means. An electrocardiogram, a heart sound diagram, and a pulsation diagram of the living body can be displayed, and at least of primary differential data obtained by differentiating a time-beat waveform with respect to time and secondary differential data obtained by differentiating the primary differential data with respect to time. One of the biological reaction recording apparatuses is characterized in that one of them can be displayed.

  A tenth invention (hereinafter referred to as invention 10) as an example of the present invention developed by developing the inventions 1 to 9 is the biological reaction recording device according to any one of the inventions 1 to 9, wherein the biological reaction recording is performed. A biological reaction recording apparatus characterized in that the apparatus has means for detecting and displaying at least one of pulsation amplitude and amplitude distribution.

  An eleventh invention (hereinafter referred to as invention 11) as an example of the present invention developed from the invention 10 is the biological reaction recording apparatus according to the invention 10, wherein at least one of the amplitude of the pulsation and the amplitude distribution is provided. It is a biological reaction recording apparatus characterized by being able to display the temporal change of the above.

  A twelfth invention (hereinafter referred to as invention 12) as an example of the present invention developed by developing the inventions 1 to 11 is the biological reaction recording device according to any one of the inventions 1 to 11. A biological reaction recording apparatus characterized in that the apparatus has means for detecting and displaying at least one of pulsation intensity and intensity distribution.

  A thirteenth invention (hereinafter referred to as invention 13) as an example of the present invention developed by developing the invention 12 is the biological reaction recording device according to the invention 12, wherein at least one of the intensity of the pulsation and the intensity distribution is provided. It is a biological reaction recording apparatus characterized by being able to display the temporal change of the above.

  A fourteenth invention (hereinafter referred to as invention 14) as an example of the present invention developed from the inventions 10 to 13 is the biological reaction recording device according to any one of the inventions 10 to 13, wherein the pulsation A biological reaction recording apparatus capable of displaying an amplitude or intensity distribution as a three-dimensional figure.

  A fifteenth invention (hereinafter referred to as invention 15) as an example of the present invention developed by developing the invention 14 is the biological reaction recording device according to the invention 14, wherein the distribution of the amplitude or intensity of the pulsation A biological reaction recording apparatus capable of displaying a cross-sectional view at a predetermined position of a three-dimensional figure.

  A sixteenth invention (hereinafter referred to as invention 16) as an example of the invention made by developing the inventions 1 to 15 is the biological reaction recording device according to any one of the inventions 1 to 15, wherein A biological reaction recording apparatus characterized in that a detection site is a chest.

  A seventeenth invention (hereinafter referred to as invention 17) as an example of the present invention developed by developing the inventions 1 to 16 is the biological reaction recording device according to any one of the inventions 1 to 16, wherein A biological reaction recording apparatus characterized in that a detection site is an abdomen.

  An eighteenth invention (hereinafter referred to as invention 18) as an example of the present invention developed from the inventions 1 to 17 is the biological reaction recording apparatus according to any one of the inventions 1 to 17. The apparatus is a biological reaction recording apparatus characterized by having past data storage means for storing past data of the same measured living body and capable of displaying a change in diagnostic information of the health state of the living body.

  A nineteenth invention (hereinafter referred to as invention 19) as an example of the present invention developed from the inventions 1 to 18 is the biological reaction recording device according to any one of the inventions 1 to 18, wherein the biological reaction recording is performed. The apparatus is a biological reaction recording apparatus characterized by having statistical data storage means for storing statistical data of at least one of the same living body and a plurality of living bodies.

  A twentieth invention (hereinafter referred to as invention 20) as an example of the present invention developed from the inventions 1 to 19 is the biological reaction recording device according to any one of the inventions 1 to 19, wherein the biological reaction recording is performed. The apparatus is a biological reaction recording apparatus characterized in that the apparatus can perform transmission / reception with another apparatus.

  A twenty-first invention (hereinafter referred to as invention 21) as an example of the present invention developed by developing the invention 20 is the biological reaction recording apparatus according to the invention 20, wherein the biological reaction recording apparatus is connected to a telemedicine system. A biological reaction recording apparatus characterized in that it is a device capable of transmitting and receiving and managing the health condition of a living body to be measured.

  A twenty-second invention (hereinafter referred to as invention 22) as an example of the present invention developed by developing the invention 20 or 21 is the biological reaction recording apparatus according to the invention 20 or 21, wherein the biological reaction recording apparatus is other. A biological reaction recording device characterized in that at least a pressure sensor is included in a portion of the device that is attached to a living body to be measured.

  A twenty-third invention (hereinafter referred to as invention 23) as an example of the present invention developed by developing the inventions 1-22 is the biological reaction recording device according to any one of the inventions 1-22, wherein the pressure sensor is A biological reaction recording apparatus comprising a plurality of pressure detection units (also referred to as pressure sensor units) or a two-dimensional pressure sensor configured by two-dimensionally arranging a plurality of pressure detection elements.

  A twenty-fourth invention (hereinafter referred to as invention 24) as an example of the present invention developed by developing the inventions 1 to 23 is the biological reaction recording device according to any one of the inventions 1 to 23, wherein the pressure sensor is A biological reaction recording apparatus comprising a two-dimensional pressure sensor in which a plurality of pressure detection units or a plurality of pressure detection elements are arranged concentrically.

  A twenty-fifth invention (hereinafter referred to as invention 25) as an example of the present invention developed by developing the inventions 1 to 24 is the biological reaction recording device according to any one of the inventions 1 to 24, wherein the pressure sensor is The biological reaction recording apparatus is a two-dimensional pressure sensor in which a plurality of pressure detection units or a plurality of pressure detection elements are radially arranged.

  A twenty-sixth invention (hereinafter referred to as invention 26) as an example of the present invention developed from the inventions 1 to 25 is the biological reaction recording device according to any one of the inventions 1 to 25, wherein the pressure sensor is The biological reaction recording apparatus is a two-dimensional pressure sensor having at least three pressure detection elements or pressure detection units in two directions in which a plurality of pressure detection units or a plurality of pressure detection elements are orthogonal to each other.

  A twenty-seventh invention (hereinafter referred to as invention 27) as an example of the present invention developed from the inventions 1 to 26 is the biological reaction recording device according to any one of the inventions 1 to 26, wherein the pressure sensor is The biological reaction recording apparatus is a pressure sensor configured by two-dimensionally arranging a plurality of pressure detection elements on a support substrate.

  According to a twenty-eighth invention (hereinafter referred to as invention 28) as an example of the present invention developed from the inventions 1-27, the biological reaction recording apparatus according to any one of the invention 1-27, the pressure sensor It is a biological reaction recording apparatus characterized by having at least one three-dimensional pressure sensor.

  A twenty-ninth invention (hereinafter referred to as invention 29) as an example of the present invention developed by developing the inventions 1-28 is the biological reaction recording apparatus according to any one of the inventions 1-28, wherein the pressure sensor is A pressure transmitting part between the part of the living body to be in contact with the surface of the part to be measured and the pressure detecting part of the pressure sensor, and the pressure transmitting part is a part of the cross section in contact with the surface of the part to be measured. The living body reaction recording apparatus is characterized in that the area of the body is larger than the area on the pressure detection unit side.

  A thirtieth invention (hereinafter referred to as invention 30) as an example of the present invention developed from the inventions 1 to 29 is the biological reaction recording device according to any one of the inventions 1 to 29, wherein the pressure sensor A biological reaction recording apparatus, wherein the pressure detection unit is a pressure sensor (hereinafter, also referred to as a piezoelectric pressure sensor or a piezoelectric pressure sensor) that is a pressure detection unit using a piezoelectric effect.

  The thirty-first invention (hereinafter referred to as invention 31) as an example of the present invention developed from the inventions 1 to 30 is the biological reaction recording device according to any one of the inventions 1 to 30, wherein the pressure sensor is A biological reaction recording apparatus characterized by being a piezo pressure sensor using a semiconductor.

  A thirty-second invention (hereinafter referred to as invention 32) as an example of the invention made by developing the inventions 1-31 is the biological reaction recording apparatus according to any one of inventions 1-31, wherein the pressure sensor The living body reaction recording apparatus is characterized in that the pressure detection unit has a pressure sensor (hereinafter also referred to as a capacitance type pressure sensor) which is a pressure detection unit using a change in capacitance.

  A thirty-third invention as an example of the present invention developed from the thirty-second invention (hereinafter referred to as thirty-third invention) is the biological reaction recording apparatus according to the thirty-second invention, wherein the pressure sensor is formed using a semiconductor. It is a biological reaction recording device characterized by being a pressure sensor.

  A thirty-fourth invention (hereinafter referred to as invention 34) as an example of the present invention developed by developing the inventions 23 to 33 is the biological reaction recording device according to any one of the inventions 23 to 33, wherein the pressure sensor A biological reaction recording apparatus, wherein the pressure detection unit or the pressure transmission unit is arranged in a region where the outer periphery is generally a circle.

  A thirty-fifth invention (hereinafter referred to as invention 35) as an example of the present invention developed by developing the inventions 23 to 33 is the biological reaction recording device according to any one of the inventions 23 to 33, wherein the pressure sensor The biological reaction recording apparatus is characterized in that the pressure detection part or the pressure transmission part is arranged in a region where the outer periphery is generally a polygon having a quadrangle or more.

  A thirty-sixth invention (hereinafter referred to as invention 36) as an example of the present invention developed from the inventions 1-35 is the biological reaction recording device according to any one of the inventions 1-35, wherein the pressure sensor is The biological reaction recording apparatus is characterized in that the outer shape of the mounted outer body is a round shape such as a circular shape or an oval shape.

  A thirty-seventh invention (hereinafter referred to as invention 37) as an example of the present invention developed from the inventions 1-36 is the biological reaction recording device according to any one of the inventions 1-36, wherein the pressure sensor The pressure-detectable range is a biological reaction recording device characterized in that the diameter of the circumscribed circle is a range of 30 mm or more.

  According to a thirty-eighth aspect of the present invention developed from the thirty-seventh aspect of the present invention (hereinafter, referred to as the thirty-eighth aspect), the biosensor recording apparatus according to the thirty-seventh aspect is characterized in that the pressure-detectable range of the pressure sensor A biological reaction recording apparatus characterized in that the diameter of a circle is in a range of 40 mm or more.

  A thirty-ninth invention (hereinafter referred to as invention 39) as an example of the present invention developed by developing the inventions 1-38 is the biological reaction recording apparatus according to any one of the inventions 1-38. The living body reaction recording apparatus is characterized in that at least the shape of the part in contact with the living body to be measured is formed in a deformable state.

  40th invention as an example of the present invention developed from the inventions 1 to 39 (hereinafter referred to as invention 40) is the biological reaction recording apparatus according to any one of the inventions 1 to 39. The apparatus includes at least one of a contact pressure between the pressure sensor and the living body to be measured or a difference between at least two pressure detecting elements constituting the pressure sensor or a contact pressure between each pressure detecting portion and the living body to be measured. It is a living body reaction recording device characterized by having contact pressure detecting means which can detect.

  The forty-first invention (hereinafter referred to as invention 41) as an example of the present invention developed by developing the invention 39 or 40 is the biological reaction recording apparatus according to the invention 39 or 40, wherein the biological reaction recording apparatus comprises: A biological reaction recording apparatus comprising: means for changing the contact pressure corresponding to the contact pressure detected by the contact pressure detecting means.

  A forty-second invention (hereinafter referred to as invention 42) as an example of the present invention developed from the inventions 1-41 is the biological reaction recording device according to any one of the inventions 1-41. The apparatus is a biological reaction recording apparatus characterized by having means for attaching the pressure sensor to the measurement subject in a state where the measurement is possible at the measurement part of the measurement subject.

  A forty-third invention (hereinafter referred to as invention 43) as an example of the present invention developed by developing the invention 42 is a biological reaction recording apparatus according to the invention 42, wherein the pressure sensor is attached to a measurement subject. Is a biological reaction recording apparatus characterized in that is a means using suction force.

  The forty-fourth invention (hereinafter referred to as invention 44) as an example of the present invention developed by developing the invention 42 or 43 is the biological reaction recording apparatus according to the invention 42 or 43, wherein the pressure sensor is used as a living body to be measured. The biological reaction recording apparatus is characterized in that the means to be attached to is a means utilizing adhesive force.

  Forty-fifth invention (hereinafter referred to as invention 45) as an example of the present invention developed by developing the inventions 1 to 44 is the biological reaction recording device according to any one of the inventions 1 to 44. The apparatus is a recording apparatus capable of presenting at least one of the measurement data, the detection data, and the diagnostic information of the health state of the living body as at least one of a still image and a moving image in real time. It is.

  A forty-sixth aspect of the present invention (hereinafter referred to as "invention 46"), which is an example of the present invention developed from the above-mentioned aspects of the inventions 1 to 45, is measured in the biological reaction recording device according to any one of the aspects 1 to 45. The biological reaction recording apparatus is characterized in that at least part of the data and the detection data is normalized data.

  Forty-seventh invention (hereinafter referred to as invention 47) as an example of the present invention developed by developing the inventions 1 to 46 is the biological reaction recording device according to any one of the inventions 1 to 46. The device is a biological reaction recording device capable of displaying at least one pulsation diagram among the pulsation diagrams as the detection data.

  The forty-eighth invention (hereinafter referred to as invention 48) as an example of the present invention developed from the invention 47 is the biological reaction recording device according to the invention 47, wherein the biological reaction recording device is used as the detection data. A biological reaction recording apparatus capable of displaying an electrocardiogram and an electrocardiogram.

  A forty-ninth aspect of the present invention (hereinafter referred to as "invention 49") as an example of the present invention developed from the first to fourth aspects of the present invention is the biological reaction recording apparatus according to any one of the first to 48th aspects. The apparatus is a biological reaction recording apparatus comprising sampling means for sampling at least one of the measurement data of the sensor and the detection data.

  The fifty-fifth invention (hereinafter referred to as invention 50) as an example of the present invention developed from the first to fourth inventions is the biological reaction recording device according to any one of the first to 49th inventions. The biological reaction recording apparatus, wherein the apparatus has a noise removing unit that removes noise from at least one of processing data such as measurement data of the sensor and detection data.

  A fifty-first invention (hereinafter referred to as invention 51) as an example of the present invention developed from the first to fifth inventions is the biological reaction recording apparatus according to any one of the first to 50th inventions. The apparatus is a biological reaction recording apparatus comprising a condition changing means that allows a user of the biological reaction recording apparatus to change at least one of a data processing condition, a sampling condition, and a noise removal condition. .

  A fifty-second invention (hereinafter referred to as invention 52) as an example of the present invention made by developing the inventions 1 to 51 is the biological reaction recording device according to any one of the inventions 1 to 51, wherein at least one of the above In signal processing of data measured as a change in pressure of movement of a pulsation detection site, a filter cutoff frequency or time constant of a signal processing circuit that processes measurement data of the pressure sensor is a parameter (hereinafter also referred to as parameter 1). As a result, the result of performing signal processing of the measurement data with the parameter 1 having a different value for the same or the same kind of pressure sensor measurement data is used as diagnostic information for the health condition of the living body. This is a biological reaction recording device.

  A thirty-third invention (hereinafter referred to as invention 53) as an example of the present invention developed by developing the inventions 10 to 52 is the biological reaction recording device according to any one of the inventions 10 to 52, wherein A biological reaction recording apparatus characterized in that a measurement area of a living body when detecting or displaying either or both of an amplitude distribution and an intensity distribution is a circular range having a diameter of at least 5 mm.

  54th invention (henceforth the invention 54) as an example of this invention made | formed by developing said invention 1-53 is the biological reaction recording apparatus in any one of invention 1-53, The said biological reaction recording. The apparatus has a data for comparing with the detection data (hereinafter also referred to as reference data), and has a means for comparing the detection data with the reference data. .

  The fifty-fifth invention (hereinafter referred to as invention 55) as an example of the present invention developed from the present invention 54 is the biological reaction recording device according to the invention 54, wherein the biological reaction recording device uses the reference data. A biological reaction recording apparatus comprising at least one of a changing means and an adding means.

  The fifty-sixth invention (hereinafter referred to as invention 56) as an example of the present invention developed by developing the invention 54 or 55 is the biological reaction recording device according to the invention 54 or 55, wherein the detection data and the reference data are used. The biological reaction recording apparatus is characterized in that the means for comparing is means for detecting and displaying a difference between the detection data and the reference data.

  A fifty-seventh invention (hereinafter referred to as invention 57) as an example of the present invention developed by developing the inventions 54 to 56 is the biological reaction recording device according to any one of the inventions 54 to 56. The biological reaction recording apparatus includes data using an extreme value of the reference data.

  A 58th invention as an example of the present invention developed from the inventions 1 to 57 (hereinafter referred to as invention 58) is the biological reaction recording device according to any one of the inventions 1 to 57. The apparatus is a biological reaction recording apparatus having a pattern matching diagnostic unit that generates diagnostic information using a pattern matching technique.

  A fifty-ninth invention (hereinafter referred to as invention 59) as an example of the present invention developed from the first to fifth inventions is the biological reaction recording device according to any one of the first to 58th inventions. The apparatus is a biological reaction recording apparatus having means for setting a measurement condition of a pulsation diagram using an area between a time-beat waveform of a pulsation diagram and a time axis.

  A 60th invention as an example of the present invention made to solve the problem (hereinafter also referred to as the invention 60) includes at least one of a cardiac apex beat, a right ventricular beat, and a left atrial beat. As a measurement result of pressure change, at least one of pulsation, ascending aorta pulsation, pulmonary artery (including at least one of pulmonary artery trunk and central pulmonary artery), abdominal aorta pulsation or liver pulsation A novel biological reaction recording device capable of detecting and recording, wherein the biological reaction recording device is measured as a pressure sensor capable of measuring the movement of at least one pulsation detection site as a pressure change. A data processing means such as an arithmetic processing unit capable of detecting biological information based on the amplifying means of the signal and the measured data, and at least a main part of the measured data and the detection data; Storage means capable of storing at least one of the display means and display means, and the storage means can store at least one of the measurement data and at least one of the detection data, and the same measured object The biological reaction recording apparatus is characterized in that it can store a change in detection data of a living body over time.

  The 61st invention as an example of the present invention developed from the invention 60 (hereinafter referred to as invention 61) is the biological reaction recording apparatus according to the invention 60, wherein the biological reaction recording apparatus includes an electrocardiogram measurement sensor and a heart sound. It is a biological reaction recording device characterized by having a figure measuring sensor.

  A twenty-second invention (hereinafter referred to as invention 62) as an example of the present invention developed by developing the invention 60 or 61 is the biological reaction recording apparatus according to the invention 60 or 61, in which the biological reaction recording apparatus is covered. A biological reaction recording apparatus characterized in that at least one of electrocardiogram and electrocardiogram data of a measurement living body can be input from the outside of the biological reaction recording apparatus and can be synchronized with the at least one data. .

  A 63rd invention as an example of the present invention made to solve the problem (hereinafter also referred to as an invention 63) includes at least one of a cardiac apex beat, a right ventricular beat, and a left atrial beat. As a measurement result of pressure change, at least one of pulsation, ascending aorta pulsation, pulmonary artery (including at least one of pulmonary artery trunk and central pulmonary artery), abdominal aorta pulsation or liver pulsation A novel biological reaction recording method capable of detecting and recording, wherein the biological reaction recording method measures the movement of at least one pulsation detection site as a pressure change at a plurality of locations in the vicinity of the location to be measured. And at least one of the pulsation detection site movements, the biological information is obtained from the data measured as the pressure change by the pressure sensor. It means for output, means for storing the detected biometric information, a biological reaction recording method characterized by using the means for displaying the diagnostic information on the state of health of the living body based on the detected biological information.

  The sixty-fourth invention (hereinafter referred to as invention 64) as an example of the present invention developed from the invention 63 is the biological reaction recording method according to the invention 63, wherein the biological reaction recording method includes an electrocardiogram measurement sensor and a heart sound. A biological reaction recording method using a figure measuring sensor.

  The 65th invention as an example of the present invention developed from the invention 63 or 64 (hereinafter referred to as invention 65) is the biological reaction recording method according to the invention 63 or 64, wherein the electrocardiogram and heart sound of the living body to be measured. 64. A biological reaction recording method characterized in that it can be input from the outside of the biological reaction recording device using at least one of the data in the figure, and can be synchronized with at least one data according to claim 63.

  A 66th invention as an example of the present invention developed from the inventions 63 to 65 (hereinafter referred to as invention 66) is the biological reaction recording method according to any of the inventions 63 to 65, wherein the pulsation detection is performed. The biological reaction recording method is characterized in that at least one of the chest and abdomen is targeted as the site.

  The 67th invention (hereinafter referred to as invention 67) as an example of the present invention developed from the inventions 63 to 66 is the biological reaction recording method according to any of the inventions 63 to 66, wherein As the diagnostic information of the state, an electrocardiogram, a heart sound chart, and a pulsation chart are used, and at least one of primary differential data obtained by differentiating a time-beat waveform with respect to time and secondary differential data obtained by differentiating the primary differential data with respect to time. The biological reaction recording method is characterized in that information including the information is used.

  The 68th invention as an example of the present invention developed from the inventions 63 to 67 (hereinafter referred to as invention 68) is the biological reaction recording method according to any of the inventions 63 to 67, wherein the pulsation in the chest And a means for detecting and displaying at least one of amplitude, amplitude distribution, intensity, and intensity distribution.

  A 69th invention (hereinafter referred to as invention 69) as an example of the present invention developed from the inventions 63 to 68 is the biological reaction recording method according to any one of the inventions 63 to 68. The method is a biological reaction recording method using means for comparing detected data detected from the measured data with reference data.

  The 70th invention as an example of the present invention made to solve the problem (hereinafter also referred to as the invention 70) includes at least one of a cardiac apex beat, a right ventricular beat, and a left atrial beat. Pressure change and / or wave movement of at least one of pulsation, ascending aorta pulsation, pulmonary artery (including at least one of pulmonary artery trunk and central pulmonary artery), abdominal aorta pulsation or liver pulsation It is a novel biological reaction recording device that can detect and record the measurement result of the reflection of the blood, and the biological reaction recording device can measure the movement of at least one pulsation detection site as a pressure change. A biosensor information (hereinafter referred to as a life sensor) based on a pressure sensor and / or a reflection detection sensor that uses wave reflection to measure, an amplification means such as a measured signal, and the measured data. Data processing means such as an arithmetic processing unit capable of detecting information) and at least the main part of measured data and biological information detected using the data processing means or information processed using the data processing means Alternatively, data such as information in the middle of processing (hereinafter, biometric information detected using the data processing means, information processed using the data processing means, or data such as information in the middle of processing is also referred to as detection data). The pressure sensor and / or the reflection detection sensor respectively measure the pressure and / or reflection information of the living body with respect to the one pulsation to be measured. And the storage means stores at least a main portion of the measurement data at the plurality of locations and the detection data. It is a biological reaction recording apparatus characterized by capable of storing at least one of the data.

  The 71st invention (hereinafter referred to as invention 71) as an example of the invention made by developing the inventions 1 to 62 and the invention 70 is the biological reaction recording device according to any one of the inventions 1 to 62 and the invention 70. , 2 sounds (aortic valve closing sound) are identified from the heart sound diagram, and in the apex rhythm diagram waveform, it exists before 2 sounds in the time axis (horizontal axis) direction, and the interval between the 2 sounds is less than 50 msec. The positive extreme value closest to two sounds (the zero point is shown when the differential value changes from + to-) is the S point, and if there is an S point, there is a possibility of advanced left ventricular injury (contraction failure, dilation failure). If the S point is not present, left ventricular diastolic dysfunction is suggested, and / or left ventricular systolic dysfunction is suggested separately from left ventricular diastolic dysfunction, and / or moderate or higher left Information processing is performed on the assumption that the left ventricular contraction is suspected. It is a biological reaction recording apparatus characterized.

  The S point is identified from the apex rhythm diagram. Two sounds (aortic valve closing sound) are identified from the phonocardiogram. On the time axis (horizontal axis), the positive extreme value closest to two sounds with an interval between the two sounds of less than 50 msec (at the time when the differential value changes from + to-) The zero point is indicated as S point. Positive extreme values that exist before two sounds and are separated by 50 msec or more up to two sounds are not treated as S points. There is a method in which the height of the point S is not measured in the pressure value (vertical axis). The point S means the end of the systole and at the same time means the start of the diastole. The point S is an index of left ventricular diastolic disorder and an index of contraction disorder. If the S point is present, the possibility of severe left ventricular injury (contraction failure, diastolic failure) is low. If the S point is not present, a left ventricular diastolic disorder is suggested. In addition to left ventricular diastolic disorder, left ventricular contraction disorder is suggested. In addition, there are suspected cases of left ventricular hypertrophy that is moderate or higher and normal left ventricular contraction.

  The 72nd invention (hereinafter referred to as invention 72) as an example of the invention made by developing the inventions 1 to 62 and inventions 70 and 71 is described in any of inventions 1 to 62 and inventions 70 and 71. In the biological response recording device, two sounds (aortic valve closing sound) are identified from the heart phonogram, and on the time axis (horizontal axis), after the first sound of the apex rhythm diagram after two sounds in the apex rhythm diagram waveform. The negative extrema is the O point, the time from the 2nd sound to the O point is the 2-O time, the 2-O time is normal when it is less than 150 msec, and the information processing is performed with 150 msec or more and less than 200 msec as abnormal. This is a biological reaction recording device.

  In some cases, identifying the point O from the apex rhythm diagram can be used as important information in biological information processing. Two sounds (aortic valve closing sound) are identified from the phonocardiogram. On the time axis (horizontal axis), the first negative extreme value in the apex rhythm diagram is defined as point O after 2 msec from the second sound in the apex rhythm diagram waveform. The time from two sounds to point O is called 2-O time. A 2-O time of less than 150 msec is regarded as normal, and a time of 150 msec or more and less than 200 msec is regarded as abnormal. The first negative extreme value that is 200 msec or more away from the second sound is not measured. In the pressure value (vertical axis), the apex rhythm diagram waveform is normalized, and the height of point O is set to zero. Point O is near the time of mitral valve opening. The 2-O time approximates the isovolumetric diastolic period, and the 2-O time is extended during diastolic failure. Suspension of the left ventricular myocardium, ie, hypertension, left ventricular hypertrophy due to aortic stenosis or hypertrophic cardiomyopathy, fibrosis or degenerative myocardial infarction, secondary cardiomyopathy, etc. are suspected.

  A 73rd invention (hereinafter referred to as an invention 73) as an example of the present invention made by developing the inventions 1 to 62 and the inventions 70 to 72 is the invention according to any one of the inventions 1 to 62 and the inventions 70 to 72. In the biological reaction recording apparatus, the first positive extreme value that exists after the O point and is less than 150 msec from the O point is the F point, the time from the O point to the F point is the O-F time, and the O-F time is 100 msec. The biological reaction recording apparatus is characterized in that information processing is performed with a value less than 100 msec normal and less than 150 msec abnormal.

  The first positive extreme value existing after the O point and less than 150 msec from the O point is defined as the F point. After the O point, it is not treated as a positive extreme value F point separated from the O point by 150 msec or more. The time from the point O to the point F is called the OF time. An OF time of less than 100 msec is regarded as normal, and an error of 100 msec or more and less than 150 msec is regarded as abnormal. When the OF time is 100 msec or more and less than 150 msec, the extensibility of the left ventricular myocardium is reduced, that is, hypertension, aortic stenosis or hypertrophic cardiomyopathy causes left ventricular hypertrophy, fibrosis, and degeneration Myocardial infarction, secondary cardiomyopathy, etc. are suspected.

  A 74th invention (hereinafter referred to as invention 74) as an example of the present invention made by developing the inventions 1 to 62 and inventions 70 to 73 is described in any one of inventions 1 to 62 and inventions 70 to 73. In the biological reaction recording device, in the normalized apex rhythm diagram, the height of the F point is regarded as abnormal when the height of the F point is less than 50 points, 50 points or more and less than 200 points as normal, and 200 points or more as abnormal It is the biological reaction recording device characterized by performing.

  The height of point F may be used as important information. On the vertical axis of the normalized apex rhythm diagram, the F point height is less than 50 points as abnormal, 50 points or more and less than 200 points as normal, and 200 points or more as abnormal. When the F point is less than 50 points, it indicates a left ventricular diastolic disorder. Suspension of the left ventricular myocardium, ie, hypertension, left ventricular hypertrophy due to aortic stenosis or hypertrophic cardiomyopathy, fibrosis or degenerative myocardial infarction, secondary cardiomyopathy, etc. are suspected.

  When the F point is 200 points or more, it indicates a left ventricular diastolic disorder. Suspicion of increased load during initial expansion. In some cases, left ventricular function is normal and left ventricular myocardial extensibility is particularly good.

  It may also indicate a pathological condition in the early stage of left ventricular dilation. There are two morbid states, one is a finding that suspects an absolute increased ventricular diastolic load. Diseases that increase blood flow through the mitral valve orifice (mitral regurgitation, ventricular septal defect, patent ductus arteriosus) or high cardiac output (hyperthyroidism, moderate or higher anemia, pregnancy Suspected of fever).

  Another may be suspicious of increased relative ventricular diastolic load. That is, the left ventricular myocardium is damaged and the load becomes excessive without increasing the blood flow through the mitral valve opening. The increase in the left ventricular residual blood volume at the end systole due to the left ventricular contraction disorder and the increase in the left ventricular filling pressure in the early diastole cause the left heart failure to produce a high F point. It usually presents with congestive heart failure with left ventricular enlargement and increased left ventricular filling pressure. Frequent examples include myocardial infarction patients and dilated cardiomyopathy patients.

  A 75th invention (hereinafter referred to as invention 75) as an example of the invention made by developing the inventions 1 to 62 and inventions 70 to 74 is described in any of inventions 1 to 62 and inventions 70 to 74. In the biological reaction recording device, the positive peak values of the A wave, E wave, and F wave in the primary differential waveform of the apex rhythm are respectively a point, e point, and f point, and each a point, e point, and f point are relative to each other. Compared and examined as a value, when the height of the point f is less than half the height of the point e, it is determined to be normal, and the height of the point f is more than half the height of the point e. When it is less than two-thirds, it is determined that attention is required in the boundary area, and information processing is performed by determining that the height of point f is abnormal when the height of point f is two-thirds or more of the height of point e. It is a biological reaction recording device.

  The height of point f may be used as important information. Each a point, e point, and f point are compared and examined as relative values. When the height of the point f is less than half the height of the point e, it is determined as normal. When the height of the point f is one-half or more of the height of the point e and less than two-thirds, it is determined that attention is required in the boundary area. An abnormality is determined when the height of the point f is 2/3 or more of the height of the point e.

  When the f point is relatively higher than the e point (when the f point is more than half of the e point), it indicates a load load in the initial stage of left ventricular expansion. There are two pathological conditions at this time, one is an absolute increase in ventricular diastolic load. Diseases that increase blood flow through the mitral valve orifice (mitral regurgitation, ventricular septal defect, patent ductus arteriosus) or high cardiac output (hyperthyroidism, moderate or higher anemia, pregnancy Suspected of fever). Another may be a relative ventricular diastolic load increase. That is, the left ventricular myocardium is damaged and the load becomes excessive without increasing the blood flow through the mitral valve opening. Increased left ventricular residual blood volume at the end of systole due to left ventricular contraction and increased left ventricular filling pressure in the early diastole combined cause left heart failure. It usually presents with congestive heart failure with left ventricular enlargement and increased left ventricular filling pressure. Frequent examples include myocardial infarction patients and dilated cardiomyopathy patients.

  The 76th invention (hereinafter referred to as the invention 76) as an example of the present invention made by developing the inventions 1 to 62 and the inventions 70 to 75 is the invention according to any one of the inventions 1 to 62 and the inventions 70 to 75. In the biological reaction recording apparatus, the information processing is performed by determining that the height of the point A is 300 points or higher and determining that the height of the point A is less than 300 points is normal.

  There may be no A wave. If almost no positive wave is observed before point C, it is determined that there is no A wave, and neither point A nor point a exists. There may be normal cases where no load is applied at the end of the left ventricular diastole or pathological cases in which the left atrial contractile function is lost or reduced.

  A point A height of 300 points or more is abnormal, and less than 300 points is normal.

  If the height of the point A is 300 points or more, it indicates an increase in the load at the end of the left ventricular end diastole.

  Suspension of the left ventricular myocardium, ie, hypertension, left ventricular hypertrophy due to aortic stenosis or hypertrophic cardiomyopathy, fibrosis or degenerative myocardial infarction, secondary cardiomyopathy, etc. are suspected. It is also affected by an increase in load from the beginning of diastole, so it shows increased blood flow through the mitral valve opening (mitral regurgitation, ventricular septal defect, patent ductus arteriosus) and high cardiac output. Suspected condition (hyperthyroidism, moderate or higher anemia, pregnancy, fever).

  It is suspected that the left ventricular myocardium, such as myocardial infarction or dilated cardiomyopathy, is damaged and the load becomes excessive without increasing the blood flow through the mitral valve opening.

  A 77th invention (hereinafter referred to as invention 77) as an example of the invention made by developing the inventions 1 to 62 and inventions 70 to 76 is described in any one of the inventions 1 to 62 and inventions 70 to 76. In the biological reaction recording device, it is determined that the a point is more than one half of the e point is abnormal, and when the a point is more than one quarter of the e point and less than one half, it is determined that attention is required in the boundary area. The biological reaction recording apparatus is characterized in that information processing is performed by determining that point a is less than a quarter of point e as normal.

  The height of point a may be used as important information. It is clearly determined that the point a is more than half of the point e. When the point a is more than a quarter of the point e and less than a half, it is determined that attention is required in the boundary area. It is determined that point a is less than a quarter of point e as normal.

  A high point a suggests an increase in left ventricular pressure due to enhanced left atrial contraction at the end diastole.

  Suspected hypertension with reduced extensibility of left ventricular myocardium, left ventricular hypertrophy due to aortic stenosis or hypertrophic cardiomyopathy, myocardial infarction causing fibrosis or degeneration, secondary cardiomyopathy, etc.

  When point a is lower than point f, normal left ventricular function has particularly good left ventricular dilatability, or conversely, severe heart failure (compensation failure).

  The 78th invention (hereinafter referred to as the invention 78) as an example of the invention made by developing the inventions 1 to 62 and the inventions 70 to 77 is described in any one of the inventions 1 to 62 and the inventions 70 to 77. In the biological reaction recording apparatus, when the C point is less than 300 points, it is determined as normal, and when the C point is 300 points or more, it is determined as abnormal and information processing is performed.

  When C point is less than 300 points, it is determined as normal. C point is determined to be abnormal when 300 points or more. There is a possibility of increased left ventricular load at the end of diastole.

  A 79th invention (hereinafter referred to as invention 79) as an example of the present invention developed by developing the inventions 1 to 62 and inventions 70 to 78 is described in any one of inventions 1 to 62 and inventions 70 to 78. In the biological reaction recording device, the positive extreme value (the point where the first-order differential waveform changes from + to-) from point C to less than 150 msec is defined as point E, and from point C to point E is determined to be caution from 125 to 150 msec. The biological reaction recording apparatus is characterized in that information from the C point to the E point is determined to be normal when less than 125 msec is normal.

  There are cases in which the time phases of point E and point P can be used as important information.

  When the positive extreme value (the point at which the primary differential waveform changes from + to-) from point C is less than 150 msec is set as point E, and the positive extreme value is recognized only at 150 msec or more without being judged as point E from C point to less than 150 msec. Let the extreme value be P point. When point P is present, it is determined to be abnormal. Suspected left ventricular contraction disorder or moderate or greater left ventricular hypertrophy. Moderate or higher left ventricular hypertrophy may or may not be accompanied by contraction disorders.

  The 80th invention (hereinafter referred to as invention 80) as an example of the invention made by developing the inventions 1 to 62 and inventions 70 to 79 is any one of inventions 1 to 62, inventions 1 to 62, and 70 to 79. In the biological reaction recording apparatus described in the above, when the E point does not exist less than 150 msec from the C point and a positive extreme value is recognized only at 150 msec or more, the extreme value is regarded as the P point, and when the P point exists A biological reaction recording apparatus characterized in that information processing is performed by determining an abnormality.

  Watch out from point C to point E for 125msec to 150msec. May be morbid. The point from point C to point E is less than 125 msec.

  The 81st invention (hereinafter referred to as the invention 81) as an example of the invention made by developing the inventions 1 to 62 and the inventions 70 to 80 is the invention according to any one of the inventions 1 to 62 and the inventions 70 to 80. In the biological reaction recording apparatus, the biological reaction recording apparatus is characterized in that information processing is performed using determination of the presence or absence of overshoot in the F wave.

  Overshooting is a phenomenon in which, after the rising wave reaches the peak, it immediately falls downward immediately and then rises again.

  If there is an overshoot finding in the F wave, the left ventricular myocardial extensibility is normal (good compliance), or an increase in the left ventricular load at the beginning of dilation is suspected. If there is no overshoot, there is no left ventricular diastolic dysfunction, or diastolic dysfunction is implied, meaning that the extensibility of the left ventricular myocardium is reduced (poor compliance).

  The 82nd invention (hereinafter referred to as invention 82) as an example of the invention made by developing the inventions 1 to 62 and inventions 70 to 81 is the invention according to any one of inventions 1 to 62 and inventions 70 to 81. In the biological response recording device, there is an interval in which the differential value between the e-th point of the first-order differential waveform of the apex rhythm diagram and the lowest point just before the f-point is near zero, and it can be determined that the differential waveform transitions horizontally only from the differential waveform. The biological reaction recording apparatus is characterized in that information processing is performed by determining that it is normal if it is normal and determining that it is not normal if it is not.

  As will be described later with reference to FIGS. 23 and 24, the differential value between the point e of the primary differential waveform of the apex rhythm diagram and the lowest point before the point f is in the vicinity of zero, and only the differential waveform is horizontal. If there is a section in which it can be determined that there is a transition to, there is a method for determining a normal left ventricular contraction state in which it can be determined that it is normal, and if it is not, there is a left ventricular contraction disorder.

  An 83rd invention as an example of the present invention developed from the invention 82 (hereinafter referred to as the invention 83) is the biological reaction recording apparatus according to the invention 82, wherein f point of the first derivative waveform of the apex rhythm diagram is shown. Normal if the position of the lowest point just before is located in the first half of the section between the point where the differential value immediately before the lowest point is zero and the point where the differential value immediately after the lowest point is zero It is judged that it has left ventricular dilatability, and it is a biological reaction recording device characterized by performing information processing.

  The 84th invention (hereinafter referred to as invention 84) as an example of the invention made by developing the inventions 1 to 62 and inventions 70 to 83 is described in any one of inventions 1 to 62 and inventions 70 to 83. In the biological reaction recording device, each feature point (A point, C point, E point, S point, O point, F point, a point, e point, f point) of the apex rhythm diagram and / or its primary differential waveform It has a predetermined range set with respect to time phase and height with respect to at least one, and has means for determining whether or not each measured data falls within the range It is a biological reaction recording device.

  The 85th invention (hereinafter referred to as the invention 85) as an example of the present invention made by developing the inventions 1 to 62 and the inventions 70 to 84 is the invention according to any one of the inventions 1 to 62 and the inventions 70 to 84. In the biological reaction recording device, each feature point (A point, C point, E point, S point, O point, F point, a point, e point, f point) of the apex rhythm diagram and / or its primary differential waveform A means for allowing a measurer to input and set a predetermined range relating to time phase and height with respect to at least one, and means for determining whether or not each measured data falls within the range. It is a biological reaction recording device characterized by having.

  The 86th invention (referred to as invention 82) as an example of the invention made by developing the inventions 1 to 62 and inventions 70 to 85 is any one of inventions 1 to 62, inventions 1 to 62, and 70 to 85. In the biological reaction recording apparatus described above, each feature point (A point, C point, E point, S point, O point, F point, a point, e point, f point) of the apex pulsation diagram and / or its primary differential waveform ) Has a means by which a measurer can input and set a predetermined range relating to time phase and height as a figure using a tablet or the like, and each measured data is within that range. It is a biological reaction recording device characterized by having a means to determine whether to enter.

If the claims in this divisional application are referred to as new claims and the claims of the old divisional application filed on July 24, 2014 are referred to as claims of the original application, the problem will be solved in this divisional application. The following six new claims 1 to 6 have been proposed as effective new claims.
The biological reaction recording method according to claim 1 is a biological reaction recording method used in a configured biological reaction recording apparatus,
The biological response recording apparatus is configured to include a heartbeat or ascending aorta beat or pulmonary artery (pulmonary artery trunk and central pulmonary artery) as at least one kind of pulsation of the apex, right ventricle and left atrium of a living body. A novel biological reaction capable of detecting a measurement value capable of generating at least one pulsation chart of pulsation or abdominal aorta pulsation or liver pulsation (including at least one) as a measurement result of wave reflection In the recording device, biological reaction information (hereinafter referred to as biological information) is obtained based on the reflected wave detection sensor that measures the movement of at least one pulsation detection site using the reflected wave of the wave and the measured data. Biological information or data processing means detected using data processing means such as an arithmetic processing unit that can be detected, at least a main part of measured data, and data processing means Data processed using or data such as information in the middle of processing (hereinafter referred to as biometric information detected using the data processing means, data processed using the data processing means or data in the middle of processing detected data, etc. And the reflection detection sensor includes a plurality of detection sensors capable of distinguishing and measuring measurement data at a plurality of measurement sites. The reflection detection sensor can measure the reflection information of the living body with respect to one pulsation to be measured, and the storage means stores at least one of the measurement data at the plurality of locations and at least one of the detection data. Is a biological reaction recording device characterized in that
The biological reaction recording method includes a step of arranging a reflected wave detection sensor capable of detecting a measurement value of a pulsation capable of creating at least one pulsation diagram as a measurement result of reflection of the wave;
Determining the health condition of the measured living body detected based on at least one of the measurement data measured by the reflected wave detection sensor and the detection data;
A process of outputting the health status of the measured living body
It is a biological reaction recording method characterized by having.
The biological reaction recording method according to claim 2 is a biological reaction recording method used in a configured biological reaction recording apparatus,
The biological reaction recording apparatus is a novel biological reaction recording apparatus capable of detecting a measurement value capable of creating a cardiac apex rhythm diagram of a living body as a measurement result of pressure change and / or wave reflection, and at least one A pressure sensor that can measure the movement of the pulsation detection site as a pressure change and / or a reflection detection sensor that measures the reflection using wave reflection, an amplification means such as a measured signal, and a measured data Biological information or data processing detected using data processing means such as an arithmetic processing unit capable of detecting biological reaction information (hereinafter referred to as biological information) based on the data processing means and at least the main part of the measured data Storage means that can store at least one of data such as information processed using the means or information being processed Data such as biological information detected using the data processing means, information processed using the data processing means or information in the middle of processing is referred to as detection data), and the pressure sensor and / or reflection detection. The sensor is composed of a plurality of detection sensors capable of distinguishing and measuring the measurement data at a plurality of measurement sites, and the pressure sensor and / or the reflection detection sensor is configured to detect the pressure of the living body and the one pulsation to be measured. It is possible to measure reflection information respectively, and / or the storage means can store at least one of the measurement data of the plurality of locations and at least one of the detection data, the biological reaction recording device,
The biological reaction recording method includes:
Arranging a reflected wave detection sensor capable of detecting a measurement value of a pulsation capable of creating at least one pulsation diagram as a measurement result of reflection of the wave;
Determining the health condition of the measured living body detected based on at least one of the measurement data measured by the reflected wave detection sensor and the detection data;
A process of outputting the health status of the measured living body
It is a biological reaction recording method characterized by having.
The biological reaction recording method according to the new claim 3, the biological reaction recording method according to the new claim 2,
Characteristic points related to apex rhythm are identified as 2 sounds (aortic valve closing sound) from the phonogram during the 1 pulsation period, and before the 2nd sound in the time axis (horizontal axis) direction in the apex rhythm diagram The positive extreme value closest to two sounds that are less than 50 msec apart from the two sounds is the S point, and when there is a negative extreme value near the apex of the QRS wave on the electrocardiogram, the negative extreme point is the C point If there is no negative extreme value near the apex of the QRS wave of the electrocardiogram, a perpendicular line is taken from the R of the electrocardiogram, and the point where the perpendicular intersects the apex rhythm waveform is the C point. If the A wave has a positive extreme value as point A, and the A wave does not have a positive extreme value and rises continuously and reaches point C, which will be described later, C point is regarded as point A, C point The positive extreme value less than 150 msec from E point is E point, and when neither E point nor S point exists, 150m from C point The positive extreme value that is delayed by ec and more than 50 msec before the second sound of the phonogram is P point, and the first negative extreme value of the apex rhythm diagram is O point after 50 msec or more from the second sound, The first positive extreme value less than 150 msec from O point is the F point, the positive wave due to left atrial contraction is the A wave, the left ventricular systolic wave is the E wave, and the rapid inflow wave is the F wave And the positive peak values of the A wave, E wave, and F wave in the first derivative waveform of the apex rhythm are a point, e point, and f point, respectively, and the amplitude axis (vertical axis) of the apex rhythm waveform is the minimum value. Is normalized to 0 points and the maximum value is normalized to 1000 points.
The biological reaction recording method includes:
And having the step of determining the presence or absence of at least one of the feature points, and
Determination means for determining whether the height of point A is less than 300 points or 300 points or more;
Determination means for determining whether the height of point C is less than 300 points or 300 points or more;
determining means for determining whether the height of the point a is less than a quarter of the point e, or more than a quarter, less than a half, or more than a half; ,
Determination means for determining whether the height of the F point is less than 50 points, 50 points or more, less than 200 points, or 200 points or more;
determining means for determining whether the height of the point f is less than half of the point e, or more than half, and less than two thirds, or more than two thirds; ,
When determining means for determining whether or not the F wave has an overshoot,
The biological reaction recording method further includes:
It is a biological reaction recording method characterized by having at least one determination means among the respective determination means as a step of determining the health state of the living body to be measured.
The biological reaction recording method according to claim 4 is the biological reaction recording method according to any one of claims 1 to 3, wherein the determination is performed in the step of outputting the determined health state of the measured living body. A biological reaction recording method characterized by using information or display means for indicating the health level of a living body to be measured such as health, caution 1, caution 2, danger and the like.
The biological reaction recording method according to claim 5 is the biological reaction recording method according to any one of claims 1 to 4, wherein the pressure sensor and / or the reflection detection sensor of the biological reaction recording device are arranged. And the portion where the pressure sensor and / or the reflection detection sensor are not arranged is referred to as the second portion of the biological reaction recording device. A recording method comprising a step of arranging a first part of a biological reaction recording device in a measured part of a living body to be measured and arranging the second part in another part. It is.
The biological reaction recording device according to claim 6 is the biological reaction recording device according to any one of claims 1 to 5, wherein the first part of the biological reaction recording device is a measured position of the living body to be measured. And the second part of the biological reaction recording apparatus is arranged at a position different from the arrangement position of the first part, and the first part and the second part of the biological reaction recording apparatus are wirelessly communicated and / or A biological reaction recording device configured to transmit information by wired communication.
In the former divisional application, 20 items of claims 1 to 20 of the following original application have been proposed as claims of the original application effective for solving the problems.
The biological reaction recording apparatus according to claim 1 of the original application is a novel living body capable of detecting a measurement value capable of creating a cardiac apex rhythm diagram as a measurement result of pressure change and / or wave reflection. A reaction recording device, wherein the biological reaction recording device measures the movement of at least one pulsation detection site as a pressure change and / or reflection using wave reflection. Data processing means such as an arithmetic processing unit capable of detecting biological reaction information (hereinafter also referred to as biological information) based on the detection sensor, the amplification means for the measured signal and the measured data, and the measured data Of data such as biological information detected using at least a main part and data processing means, information processed using data processing means, or information being processed Storage means capable of storing at least one (hereinafter, data such as biological information detected using the data processing means, information processed using the data processing means, or information in the middle of processing is also referred to as detection data) The pressure sensor and / or the reflection detection sensor includes a plurality of detection sensors capable of distinguishing and measuring measurement data at a plurality of measurement sites. Alternatively, the reflection detection sensor can measure the pressure and / or reflection information of the living body with respect to one pulsation to be measured, and the storage means can store at least one of the measurement data at the plurality of locations and at least one of the detection data. In the biological reaction recording apparatus, characterized in that
Characteristic points related to apex rhythm are identified as 2 sounds (aortic valve closing sound) from the phonogram during the 1 pulsation period, and before the 2nd sound in the time axis (horizontal axis) direction in the apex rhythm diagram The positive extreme value closest to two sounds that are less than 50 msec apart from the two sounds is the S point, and when there is a negative extreme value near the apex of the QRS wave on the electrocardiogram, the negative extreme point is the C point If there is no negative extreme value near the apex of the QRS wave of the electrocardiogram, a perpendicular line is taken from the R of the electrocardiogram, and the point where the perpendicular intersects the apex rhythm waveform is the C point. If the A wave has a positive extreme value as point A, and the A wave does not have a positive extreme value and rises continuously and reaches point C, which will be described later, C point is regarded as point A, C point The positive extreme value less than 150 msec from E point is E point, and when neither E point nor S point exists, 150m from C point The positive extreme value that is delayed by ec and more than 50 msec before the second sound of the phonogram is P point, and the first negative extreme value of the apex rhythm diagram is O point after 50 msec or more from the second sound, The first positive extreme value less than 150 msec from O point is the F point, the positive wave due to left atrial contraction is the A wave, the left ventricular systolic wave is the E wave, and the rapid inflow wave is the F wave When the positive peak values of the A wave, E wave, and F wave in the first derivative waveform of the apex rhythm are a point, e point, and f point, respectively, the amplitude axis (vertical axis) of the apex rhythm waveform is In a state where the minimum value is normalized to 0 point and the maximum value is normalized to 1000 points,
The biological reaction recording apparatus has means for determining presence / absence of at least one of the feature points, and
Determination means for determining whether the height of point A is less than 300 points or 300 points or more;
Determination means for determining whether the height of point C is less than 300 points or 300 points or more;
determining means for determining whether the height of the point a is less than a quarter of the point e, or more than a quarter, less than a half, or more than a half; ,
Determination means for determining whether the height of the F point is less than 50 points, 50 points or more, less than 200 points, or 200 points or more;
determining means for determining whether the height of the point f is less than half of the point e, or more than half, and less than two thirds, or more than two thirds; ,
A biological reaction recording apparatus having at least one determination means of determination means for determining whether or not an F wave has an overshoot.
The biological reaction recording apparatus according to claim 2 of the original application is a novel living body capable of detecting a measurement value capable of generating a cardiac apex rhythm diagram as a measurement result of pressure change and / or wave reflection. A reaction recording device, wherein the biological reaction recording device measures the movement of at least one pulsation detection site as a pressure change and / or reflection using wave reflection. Data processing means such as an arithmetic processing unit capable of detecting biological reaction information (hereinafter also referred to as biological information) based on the detection sensor, the amplification means for the measured signal and the measured data, and the measured data Of data such as biological information detected using at least a main part and data processing means, information processed using data processing means, or information being processed Storage means capable of storing at least one (hereinafter, data such as biological information detected using the data processing means, information processed using the data processing means, or information in the middle of processing is also referred to as detection data) The pressure sensor and / or the reflection detection sensor includes a plurality of detection sensors capable of distinguishing and measuring measurement data at a plurality of measurement sites. Alternatively, the reflection detection sensor can measure the pressure and / or reflection information of the living body with respect to one pulsation to be measured, and the storage means can store at least one of the measurement data at the plurality of locations and at least one of the detection data. In the biological reaction recording apparatus, characterized in that
The biological reaction recording apparatus has a means for determining the presence / absence of at least two of the feature points, and a noise processing means for removing noise from at least one of the measurement data of the sensor and the processed data. It is the biological reaction recording device characterized by the above-mentioned.
The biological reaction recording apparatus according to claim 3 of the original application is a novel living body capable of detecting a measurement value capable of generating a cardiac apex rhythm diagram as a measurement result of pressure change and / or wave reflection. A reaction recording device, wherein the biological reaction recording device measures the movement of at least one pulsation detection site as a pressure change and / or reflection using wave reflection. Data processing means such as an arithmetic processing unit capable of detecting biological reaction information (hereinafter also referred to as biological information) based on the detection sensor, the amplification means for the measured signal and the measured data, and the measured data Of data such as biological information detected using at least a main part and data processing means, information processed using data processing means, or information being processed Storage means capable of storing at least one (hereinafter, data such as biological information detected using the data processing means, information processed using the data processing means, or information in the middle of processing is also referred to as detection data) The pressure sensor and / or the reflection detection sensor includes a plurality of detection sensors capable of distinguishing and measuring measurement data at a plurality of measurement sites. Alternatively, the reflection detection sensor can measure the pressure and / or reflection information of the living body with respect to one pulsation to be measured, and the storage means can store at least one of the measurement data at the plurality of locations and at least one of the detection data. In the biological reaction recording apparatus, characterized in that
The biological reaction recording device has means for determining the presence or absence of at least two of the feature points,
Data such as biological information detected using data processing means from at least the main part of measured data, information processed using data processing means, or information in the middle of processing (hereinafter, detected using data processing means) The biological reaction recording apparatus is characterized in that it has reference data that compares the biological information or information processed using the data processing means or data in the middle of processing with detection data).
Biological reaction apparatus according to claim 4 of the original application, the biological reaction apparatus according to claim 3 of the parent application, characterized in that it is possible to input the reference data from the outside of the biological reactions recorder It is a biological reaction recording device.
Biological reaction apparatus according to claim 5 of the original application, the biological reaction apparatus according to claim 3 of the parent application, biological response recording, characterized in that it comprises a means for changing the reference data Device.
The biological reaction recording apparatus according to claim 6 of the original application is a novel living body capable of detecting a measurement value capable of generating a cardiac apex rhythm diagram as a measurement result of pressure change and / or wave reflection. A reaction recording device, wherein the biological reaction recording device measures the movement of at least one pulsation detection site as a pressure change and / or reflection using wave reflection. Data processing means such as an arithmetic processing unit capable of detecting biological reaction information (hereinafter also referred to as biological information) based on the detection sensor, the amplification means for the measured signal and the measured data, and the measured data Of data such as biological information detected using at least a main part and data processing means, information processed using data processing means, or information being processed Storage means capable of storing at least one (hereinafter, data such as biological information detected using the data processing means, information processed using the data processing means, or information in the middle of processing is also referred to as detection data) The pressure sensor and / or the reflection detection sensor includes a plurality of detection sensors capable of distinguishing and measuring measurement data at a plurality of measurement sites. Alternatively, the reflection detection sensor can measure the pressure and / or reflection information of the living body with respect to one pulsation to be measured, and the storage means can store at least one of the measurement data at the plurality of locations and at least one of the detection data. In the biological reaction recording apparatus, characterized in that
The biological reaction recording device has means for determining the presence or absence of at least two of the feature points,
A biological reaction recording apparatus comprising data processing means for generating judgment information using a pattern matching technique.
Biological reaction apparatus according to claim 7 of the original application, the biological reaction apparatus according to claim 1 of the original application, as the pressure change of at least one motion detection portion of the pulsation In the signal processing of the measured data, the cutoff frequency or time constant of the filter of the signal processing circuit that processes the measurement data of the sensor is used as a parameter (hereinafter also referred to as parameter 1), and the measurement data of the same or the same type of sensor is used. On the other hand, the biological reaction recording apparatus is characterized in that the result of performing signal processing of measurement data with the parameter 1 having a different value is used as diagnostic information on the health state of the living body.
Biological reaction apparatus according to claim 8 of the original application, the biological reaction apparatus according to claim 1 of the original application, the shape of the portion in contact with at least the measured biological the sensor deformation The biological reaction recording device is characterized by being formed in a possible state.
Biological reaction apparatus according to claim 9 of the original application, formed in a biological reaction apparatus according to any one of claims 1 to 8 of the original application, at least in part in contact with the measured biometric of the sensor is flexible It is the biological reaction recording device characterized by the above-mentioned.
The biological reaction apparatus according to claim 10 of the original application, the biological reaction apparatus according to claim 1 of the original application, the biological reaction recording apparatus, the sensor and the measured living body A contact pressure detecting means capable of detecting at least one of a contact pressure between the at least two pressure detecting elements constituting the sensor or a difference in contact pressure between each pressure detecting portion and a living body to be measured. It is the biological reaction recording device characterized by the above-mentioned.
Biological reaction apparatus according to claim 11 of the original application, the biological reaction apparatus according to claim 9 or 10 of the original application, the biological reaction recording apparatus, the contact pressure which the contact pressure detected by the detecting means A biological reaction recording apparatus comprising means for changing the contact pressure corresponding to
Biological reaction apparatus according to claim 12 of the original application, the biological reaction apparatus according to any one of claims 1 to 11 in the original application, the biological reaction recording apparatus, measures the sensor of the measured biological It is a biological reaction recording device characterized by having means for attaching to a living body to be measured in a state where the measurement at the part is possible.
Biological reaction apparatus according to claim 13 of the original application, it in biological reactions recording apparatus according to claim 12 of the original application, means for mounting the sensor to be measured living body is a means which utilizes the attractive force A biological reaction recording apparatus characterized by the above.
The biological reaction apparatus according to claim 14 of the original application, the biological reaction apparatus according to claim 12 or 13 of the original application, a means of means for mounting the sensor to be measured living body using the adhesive force It is a biological reaction recording device characterized by being.
Biological reaction apparatus according to claim 15 of the original application, the biological reaction apparatus according to any one of claims 1 to 14 in the original application, the biological reaction recording apparatus for detecting data and biometric said measurement data The biological reaction recording apparatus is a recording apparatus capable of presenting at least one of health condition diagnosis information as at least one of a still image and a moving image in real time.
Biological reaction apparatus according to claim 16 of the original application, the biological reaction apparatus according to any one of claims 1 to 15 of the original application, the biological reaction recording apparatus having the same biological and multiple biological least one of A biological reaction recording device comprising statistical data storage means for storing statistical data.
The biological reaction apparatus according to claim 17 of the original application, the biological reaction apparatus according to any one of claims 1 to 16 of the original application, the apex cardiogram or the measurement data of the measured biological electrocardiogram The biological reaction recording apparatus is characterized by being synchronized with any one of a heart sound diagram and externally input data.
Biological reaction apparatus according to claim 18 of the original application, the biological reaction apparatus according to any one of claims 1 to 17 of the original application, the distribution of the amplitude or intensity of the pulsation as a three-dimensional figure And / or a biological reaction recording device capable of displaying a cross-sectional view of a predetermined position of a three-dimensional figure.
The biological reaction apparatus according to claim 19 of the original application, the biological reaction apparatus according to any one of claims 1 to 18 of the original application, the diameter of the pressure detection range is the circumcircle of the sensor 30mm The biological reaction recording device is in the above range.
Biological reaction apparatus according to claim 20 of the original application, the biological reaction apparatus according to any one of claims 1 to 18 of the original application, either or both of the amplitude distribution and the intensity distribution of the pulsation The living body reaction recording apparatus is characterized in that a measurement area of a living body when detecting and displaying is a circular range having a diameter of at least 5 mm.
Conventionally, the pulsation is obtained as a whole or average value of the range in which the microphone is brought into close contact with the representative point in the chest by having the subject enter the environment where noise is difficult to enter as described above. The apex rhythm diagram was obtained by measurement, and the record was recorded on paper. However, this could not be used for actual diagnosis as described above.

  And, the microphone used in the conventional cardiograph recording device requires expert knowledge for setting the time constant by the measurer, and the microphone should be applied correctly, but the microphone was applied correctly. It has been said that the measured data cannot be used for diagnosis as a heartbeat diagram by setting the time constant by the measurer alone.

  The biological reaction recording device and the biological reaction recording method of the present invention also solve this problem, and the problem of the time constant is solved inside the measuring device. For example, the circuit is configured according to the necessity depending on the usage situation of the pressure sensor, and the measurement is performed. Thus, correct data can be obtained even if the time constant setting by the user is not a problem.

  As in each example of the present invention, in the measurement by the pressure sensor, for example, with respect to one pulsation, the characteristic that it is possible to distinguish and measure the pressures at a plurality of locations adjacent to a living body is an important feature that could not be expected in the past. In addition to being able to obtain useful information, it has the great effect of bringing long-lasting progress to diagnosis using it. Furthermore, the feature of being able to measure the pressure at multiple locations at the same time for a single pulsation is the most important information that could not be expected in the past, such as the ability to observe complex heart movements in more detail. There is a great effect that it can be obtained. The feature of extracting and measuring the maximum pressure among multiple pressures for one pulsation can be expected in the past, such as the ability to observe in detail the complex movements of the heart. This has the great effect of being able to obtain extremely important information that was not available. Furthermore, in the example of the pressure sensor of the present invention, there is a great effect that it is possible to use partial average values, total values, or overall average values and total values of one-dimensional and two-dimensional pressure detection portions.

  Here, it is possible to measure at the same time, for example, when data is sampled at 1/1000 second or 1200 second, for example, when measurement data is temporarily stored in memory and read out. However, it is not limited to this. For example, when the number of pressure detection elements of the pressure sensor is n and n is a very large number In many cases, there is no problem in handling data within n seconds of 1000 minutes as data measured simultaneously. It is possible to obtain important information on heart movement by handling data within approximately 0.3 seconds as data measured at the same time.

  As a result of research by the inventors of the present invention, it is particularly preferable to obtain truly simultaneous data as a measured value as in the above example from the viewpoint of data utilization. In synchronization with at least one of the electrocardiogram and the electrocardiogram, data taken 0.02 seconds after the beginning of the QRS wave of the electrocardiogram or a specific position of one sound of the electrocardiogram, or data after 0.04 seconds or 0 Taking the data after 0.08 seconds can provide important information and is particularly preferable. Such data can be used, for example, to make a more accurate judgment on the appearance of spike waves (notches) as an impact other than the peak of the apex heartbeat graph or the apex heartbeat itself. If a notch appears near point E, it can be assumed whether it is a vibration due to the closure of the mitral valve, useful for considering the rotation of the heart, and so on.

  However, from a medical point of view, the present invention is not limited to this, and even if the measured values within 0.1 seconds are treated as simultaneously measured data, the amplitude and intensity of the pulsation can be grasped fairly accurately. Even if the measured values within 3 seconds are treated as simultaneously measured data, it is possible to roughly grasp the movement of the heart, so it can be said that the data measured with a time difference within 0.3 seconds is measured simultaneously. .

  An apex rhythm diagram measuring apparatus according to the present invention having means for designating a specific position of two sounds and means for displaying data of the rhythm diagram by designating a specific time after the specific position of two sounds was created. It was found that it can greatly contribute to the analysis of

  As data relating to the heart, various information can be obtained as data that can be used for diagnosis of the subject using data of one beat determined by the measurer from a professional point of view, but more preferably, data of at least three beats. It is practically preferable to use the average of these as data, and the accuracy of diagnosis can be improved.

  From the viewpoints of simplifying the measurement system, obtaining accurate data suitable for the purpose of diagnosis, and making an appropriate diagnosis according to the medical condition, sampling for multiple pulsations as appropriate, It is also possible to obtain representative beat information of multiple beats.

  Further, each of the above-mentioned inventions is obvious from the following description, but it can be developed to bring about many new inventions, and many variations are possible.

  For example, the measurement data is stored in a part of the storage means, a filter is inserted between the measurement data storage means and the signal amplification means, and the signal processing is performed by changing the filter variously. A biological reaction recording apparatus characterized in that a graph is detected and a signal obtained as a result of the detection can be used for diagnosis or the like.

  The present invention makes it possible to record the biological reaction of the chest and abdomen without using a special measurement room such as a soundproof room, for example, in an outpatient examination room or a hospital room, and also by a single doctor. This has the great effect of making it possible to make an accurate diagnosis of cardiovascular diseases.

  Examples of embodiments of the present invention will be described below with reference to the drawings. The drawings used for the description schematically show the dimensions, shapes, arrangement relationships, and the like of each component to the extent that an example of the present invention can be understood. For convenience of explanation of the present invention, there may be cases where the enlargement ratio is partially changed for illustration, and the drawings used for explanation of the examples of the present invention may not necessarily be similar to the actual objects and descriptions of the embodiments. Moreover, in each figure, about the same component, it attaches and shows the same number, The overlapping description may be abbreviate | omitted.

  Conventionally, even if an extremely large device as described above is used and environmental noise is suppressed, the living body to be measured enters a special measurement room such as a soundproof room, and various sensors for measurement are mounted on the skin. I put a recording device in the next room, etc., and sometimes I took a heartbeat diagram while watching the state of the living body to be measured and sometimes correcting the state of the sensor through the communication means, sometimes through the window.

  However, the heart diagram taken in this way is not data in the natural state of the living body to be measured, and it was thought that the actual use of the heart diagram could not be expected with a few exceptions. The actual situation was.

  The present invention can be applied to a patient who needs a heartbeat diagram that has been thought to be unusable for correct medical treatment, and can be applied to a patient who needs it. A small and inexpensive recording device that can be used at the bedside of the hospital and records past data and can be used for continuous medical care of patients. It provides educational methods.

  One of the notable features of the technical idea of the present invention is that the biological reaction recording apparatus of the present invention has a pressure sensor disposed in at least one position of the chest or abdomen of the living body, and apex pulsation, right ventricular pulsation, and left Detecting and recording as pressure change at least one of heart beat, ascending aorta beat, pulmonary artery beat, abdominal aorta beat or liver beat as at least one kind of beat of atria. A new biological reaction recording apparatus capable of measuring a plurality of pressures in the vicinity of a measured position of a living body with respect to one pulsation using a pressure sensor, and storing the measurement data in the measurement data storage means There is a place where measurement data at a plurality of locations can be stored.

  One of the features that should be noted in the technical idea of the present invention is that the pressure changes at the plurality of locations can be distinguished and stored. These pressure changes at a plurality of locations are simultaneously measured so that, for example, the complex movement of the heart can be observed in more detail.

  Furthermore, the detection data storage means can also store the time course of biological information.

  One of the remarkable features of the technical idea of the present invention is that the biological reaction recording device can be reduced in size and weight so that even a doctor can easily carry it. It is in a place where it can be made small enough to fit in.

  FIG. 1 is a block diagram illustrating a biological reaction recording apparatus as an embodiment of the present invention. 1, reference numeral 200 denotes a biological reaction recording apparatus as an embodiment of the present invention, 201 a pressure sensor that measures pulsation, 202 a heart sound sensor that measures a heart sound, 203 an electrocardiogram sensor that measures an electrocardiogram, 220 is a control / measurement data processing unit, 230 is a storage unit, 240 is a display unit, 211 is a wiring connecting the pressure sensor 201 and the control / measurement data processing unit 220, and 212 is a heart sound sensor 202 and a control / measurement data processing unit 213 is a wiring connecting the electrocardiogram sensor 203 and the control / measurement data processing unit 220, 231 is a wiring connecting the storage unit 230 and the control / measurement data processing unit 220, and 241 is a display unit. This wiring connects 240 and the control / measurement data processing unit 220.

  The pressure sensor 201 is a pressure sensor having a plurality of pressure detection elements or pressure detection units that can detect pressure measurements at a plurality of locations as data distinguished from each other. For example, a piezoelectric element such as a piezo element made of a semiconductor is used. Can be configured.

  The heart sound sensor 202 is a sensor for measuring a heart sound, and a conventional heart sound sensor can also be used.

  The electrocardiogram sensor 203 is a sensor for measuring an electrocardiogram, and a conventional electrocardiogram electrode can also be used.

  In FIG. 1, a pressure sensor 201, a heart sound sensor 202, and an electrocardiogram sensor 203 are respectively arranged at measurement points of a living body to be measured, and each measurement data is sent to the control / measurement data processing unit 220 via each wiring.

  The measurement data sent from the pressure sensor 201 is processed in the control / measurement data processing unit 220 as pulsation diagram creation data and other data, stored in the storage unit 230, and displayed on the display unit 240 as necessary. The The other data may be unnecessary, but includes, for example, a two-dimensional distribution of pressure detection intensity within a predetermined range in the chest and contact pressure.

  The measurement data sent from the heart sound sensor 202 and the electrocardiogram sensor 203 are processed by the control / measurement data processing unit 220 as data for a heart sound diagram and an electrocardiogram, respectively, stored in the storage unit 230, and displayed as necessary. Is displayed.

  FIG. 2 is a block diagram for explaining a biological reaction recording apparatus that can also perform remote management as an embodiment of the present invention.

  In FIG. 2, reference numeral 300 denotes a biological reaction recording system as an embodiment of the present invention, 301 a pressure sensor that measures pulsation, 305 a a heart sound sensor that measures a heart sound, 305 b an electrocardiogram sensor that measures an electrocardiogram, and the like. , 320 is a control / measurement data processing unit, 330 is a storage unit, 340 is a display unit, 350 is a remote management unit, 311 is a communication means for connecting the pressure sensor 301 and the control / measurement data processing unit 320, 315a is Contact means for connecting the sensor 305a and the control / measurement data processor 320, 315b for contact between the sensor 305b and the control / measurement data processor 320, 331 for the storage 330 and the control / measurement data processor 320 341 is a communication unit for connecting the display unit 340 and the control / measurement data processing unit 320, and 351 is a remote tube. A communication means between the parts 350 and the control and measurement data processing unit 320. At least a part of the contact means can be configured using communication means such as wireless communication or optical communication.

  In FIG. 2, a sensor 305 such as a pressure sensor 301 for measuring a pulsation, a heart sound sensor for measuring a heart sound and an electrocardiogram sensor for measuring an electrocardiogram, a control / measurement data processing unit 320, a storage unit 330, and a display unit 340 are biological reactions. Although it corresponds to a recording device, it is a major difference from the case of FIG. 1 in that some of the contents of the control / measurement data processing unit 320, the storage unit 330, and the display unit 340 are provided in the remote management unit 350.

  The living body reaction recording apparatus system of FIG. 2 can perform the health management of the living body to be measured based on the measurement information of the sensor by attaching the necessary minimum part of the living body reaction recording apparatus to the living body to be measured.

  FIG. 3 is a block diagram for explaining an example of measurement data processing in the biological reaction recording apparatus as an embodiment of the present invention. The flow of processing is as follows. In the figure, numerals 271 to 287 described in squares are symbols for explaining processing steps, processing contents, functions, and the like. Hereinafter, typical steps of measurement data processing will be described.

  In step 271, the measurement data of the pressure sensor and other sensors are captured, and the measurement data sampled at 12000 points for 10 seconds is stored in the memory 283, and the measurement data is input to the amplification / noise removal unit shown in step 272. The measurement data is digital data.

  In the amplification and noise removal in the amplification / noise removal unit in step 272, the conditions for noise removal such as the filter conditions are set and the measurement data is amplified.

  For example, in the case of a pulsation diagram, it is easy to evaluate by normalizing the data so that the maximum value of the pulsation amplitude appearing in 10 seconds is 1000.

  Examples of the measurement of the apex rhythm diagram according to the present invention to be described below include an example in which one waveform is normalized, and an example in which a plurality of waveforms are normalized and one waveform is shown in the center.

  The data amplified in step 272 is stored in the memory 283 and input to the waveform / graphic processing unit in step 273. In the waveform / graphic processing unit in step 273, for example, if the data is for pulsation charts (measurement data by a pressure sensor), electrocardiograms or phonocardiograms, a graph is created, and the amplitude distribution of the pulsations In the case of an intensity distribution, graphic processing is performed.

  The data that has undergone the waveform / graphic processing in step 273 is stored in the memory 283 and the feature extraction processing is performed in step 274. In the feature extraction process, for example, features such as extraction of extreme values in a graph of a pulsation diagram, comparison of magnitudes of extreme values, shapes of primary differential waveforms and secondary differential waveforms, and waveforms of pulsation diagrams are extracted.

  The data subjected to the feature extraction process in step 274 is stored in the memory 283 as detection data, and the extracted waveform, feature, etc. are evaluated in step 275. For example, the shape of the graph of the apex rhythm may vary greatly depending on the noise removal conditions in the amplification / noise removal unit in step 272. In step 275, it is determined whether or not the graph or figure obtained as a result of the waveform / graphic processing in step 273 is appropriate for the diagnosis of the living body to be measured. If you want to change the processing conditions, go to Step 284 and set new or changed amplification / noise removal conditions and feature extraction conditions in the amplification / noise removal condition setting unit, feed back to steps 272, 274, etc. Amplification, noise removal, and feature extraction are performed according to

  If it is determined in step 275 that the extracted waveform, feature, or the like is appropriate, it is stored in the memory 283 and a primary diagnosis or evaluation is performed in step 276 to create detection data such as biological information. When possible, detection data is sent to step 277 and stored in the memory 283. In step 278, information other than information based on the current measurement data such as blood pressure and drug administration information is stored as necessary. The secondary diagnosis or evaluation is performed by using the storage unit 286.

  If it is determined in step 278 that further examination is necessary, the process proceeds to steps 284 and 285, where, for example, the processing as described above is performed, and further diagnosis and evaluation are performed.

  Even when it is determined in step 275 or 278 that the extracted waveform, feature, or the like is not appropriate, it can be stored in the memory 283 as necessary.

  3 may be performed automatically or semi-automatically according to a program or the like, may be performed as a diagnosis / evaluation by a specialist, or may be performed as a combination thereof.

  If it is determined in the first diagnosis or evaluation in step 276 that there is a problem in creating detection data such as biometric information, the process moves to the processing condition setting unit in step 285 to set the waveform / graphing conditions and the like. For example, the process returns to step 273 to perform waveform / graphic processing.

  The result of the secondary diagnosis or evaluation is stored in the memory 283 and primary diagnosis information is created in step 279.

  The primary diagnosis information created in step 279 is stored in the memory 283 and the process proceeds to step 280, and the secondary diagnosis information can be created by referring to the reference data storage unit 287 as necessary.

  The reference data storage unit stores, for example, time-change information such as detection data of the same living body to be measured, statistical data that is useful for diagnosis, model patterns of pulsation charts, etc. Simple diagnosis can be realized.

The secondary diagnosis information is stored in the memory 283, and if necessary, the process proceeds to step 282 and is displayed on the display device, and the process proceeds to step 281 to create health information of the living body to be measured.

  The health information of the measurement subject created in step 281 is displayed on the display device in step 282.

  The display on the display device is not limited to this, and if necessary at each step, the process can move to step 282 each time and can be displayed on the display device. Further, the display screen can be divided into a plurality of parts and displayed at the same time, and the results of a plurality of steps can be displayed in a list. By configuring in this way, it is possible to make a more accurate and quick diagnosis.

  In the feature extraction and diagnosis of the pulsation diagram, the pulsation diagram itself is naturally important information, but as will be apparent from the examples described later, the differential data of the pulsation diagram also plays an important role. For example, when extracting features or evaluating features according to a program, performing automatic diagnosis or semi-automatic diagnosis, or interpreting a pulsation diagram that is difficult to judge, if you use primary differential and secondary differential data, In many cases, feature extraction, its evaluation, and various diagnoses can be easily performed.

  Each of the steps can have many variations. For example, the apex rhythm diagram as a graph obtained as a result of the graphic processing changes when the noise removal condition in step 272 is changed. What processing conditions should be used at what time greatly affects the accuracy of diagnosis of the apparatus. The example of the biological reaction recording apparatus of the present invention has these conditions as a part of the invention.

  The measurement data includes a measurement value by a pressure sensor of a corresponding pulsation in the chest or abdomen, but may include a measurement value by an electrocardiogram sensor and a heart sound sensor. The data for the electrocardiogram and the data for the electrocardiogram are the data measured so that the pulsatogram can be synchronized by the measuring means different from the biological reaction recording apparatus as an example of the present invention. It is also possible to configure the apparatus so that it is used by receiving it as external input data. By doing so, it is possible to reduce the size and cost of the apparatus.

  Further, as described in the means for solving the problems, the biological reaction recording apparatus as an example of the present invention covers only the pressure sensor or the minimum part including the same in the configuration shown in FIG. For example, a hospital can be attached to a measurement living body, and a transmission / reception function between the part and an external device is provided in a necessary part of the part to be attached to the measurement biological body and the external device. Can be used for remote health management, or by providing a portable device such as a personal computer, a mobile phone, or a wristwatch with the necessary functions as the external device, and as a whole, a biological reaction recording device can be configured and widely used. It can be used for health management of many people.

  FIG. 4 is a diagram for explaining an example of a pressure sensor for measuring the pulsation of the biological reaction recording apparatus as an embodiment of the present invention, in which the outer shape of the sensor is circular.

  In FIG. 4, reference numeral 201a is a pressure sensor, 241a to 241c, 242a to 242c, 243a to 243c are pressure sensor units for detecting pulsation of the living body, and 244a to 244d are pressure sensor units for detecting contact pressure with the living body. Is a semiconductor substrate, 245 is an inner wall of the outer periphery of the pressure sensor, 246 is an outer wall of the outer periphery of the pressure sensor, 247 is a space formed between the outer wall 246 and the inner wall 245, and 247a partitions the space 247. The partition portions 249a to 249d are wearing position correcting means, and 249e to 249h are microphones that can also be used for heart sound sensors.

  In FIG. 4, each pressure sensor is a piezo element formed on a semiconductor substrate 248.

  For example, the pressure sensor 201a is connected to the control / measurement data processing unit via wiring as shown in FIG. 1, and sends the measurement data of each sensor to the control / measurement data processing unit, and if necessary, It is also possible to measure based on a command sent from the control / measurement data processing unit and send the measurement value to the control / measurement data processing unit.

  The pressure sensor units 244a to 244d that detect the contact pressure with the living body can detect the contact pressure with the living body, and depending on the purpose of use of the biological reaction recording device, for example, according to a command from the control / measurement data processing unit Based on this, there may be provided means for changing the relative position between the pressure sensor 201a and the living body, such as the mounting position correcting means 249a to 249d.

  The space portion 247 may be divided into a plurality of locations, and may be used by being divided into a portion that performs a suction action and a portion that performs a pressing action.

  Depending on the purpose of use of the biological reaction recording device, the pressure in the space 247 can be changed and used to attach / detach the pressure sensor 201a to / from the living body. For example, when the space portion 247 is divided into a plurality of locations by the partition portion 247a in FIG. 4, the pressure in the space portion can be changed for each divided location, and the pressure sensor 201a is applied to the living body. It can be used for attaching / detaching or changing the relative position of the pressure sensor 201a and the living body.

  The illustrated portions of the microphones 249e to 249h may include the microphone itself, and the position of the microphone itself may be used as a sound collection hole, and a sound detection unit may be provided inside or on the back side of the substrate 248. By doing in this way, size reduction can be achieved and a sound detection characteristic can also be improved.

  Depending on the purpose of use of the biological reaction recording device, the number of pressure sensor parts for detecting the pulsation of the living body may be increased or decreased, but it is preferably three or more and particularly preferably two-dimensionally arranged. Furthermore, the pressure sensor units 244a to 244d for detecting the contact pressure with the living body may not be provided depending on the purpose of use of the biological reaction recording apparatus.

  Even if the pressure sensor 201a is configured without any or all of the mounting position correcting means 249a to 249d, the microphones 249e to 249h, and the space 247, it can be used as a pressure sensor for detecting pulsation.

  The pressure sensor 201a as shown in FIG. 4 is an example in which the pressure sensor unit for detecting the pulsation of the living body is arranged two-dimensionally in 3 rows and 3 columns, and the pressure change of the living body at the position of each pressure sensor unit, respectively. Can be measured so that the pulsation of the living body can be accurately detected. And if the measurement system is configured so that it can measure the pressure change of the living body at the position of each pressure sensor at the same time or measure it as a movie, it can be observed equivalent to or better than the palpation of the heart, Highly reliable examination can be performed.

  The number and arrangement of the two-dimensional pressure sensor units or pressure detection elements are not limited to the above. If the number of sensor units is arranged in a matrix of 3 × 3, 5 × 5, 7 × 7, etc., a sensor that can grasp the actual movement of the heart with a relatively small number of sensor units can be realized at low cost. In addition to the matrix form, the arrangement can be made concentrically or radially from the center to increase detection accuracy. From the viewpoint of operability, detection accuracy, etc., the number and manner of arrangement capable of detecting the center of the sensor unit are preferable.

  Although not shown, a well-known element MEMS can be used as a pressure sensor for detecting pressure changes at a plurality of locations.

  By utilizing semiconductor technology, a very large number of pressure sensor units can be constructed and used.

  These pressure sensor units are preferably used not only for detecting the pressure of the pulsation itself, but also for instructing correction to be a position where the pressure sensor is to be applied to the living body or an appropriate position. By doing so, a pressure sensor that is easy to use and can be measured accurately can be realized.

  The outer peripheral shape of the pressure sensor 201a is circular.

  The shape of the outer circumference of the pressure sensor is extremely important for actual measurement. Usually, the pressure sensor is applied to the skin of the living body with some pressure, so that the living body is free of pain and other pain. If the outer shape of the sensor is circular or elliptical, it is possible to perform more accurate measurement without causing pain even if the sensor is pressed strongly against the living body. For the same reason or improvement of measurement accuracy, if a flexible pressure sensor is used, a decrease in measurement accuracy due to the shape of the chest can be reduced, for example, in the case of a person with a conspicuous rib. Furthermore, it is preferable to round the corners when using a shape that is not circular but is based on, for example, a quadrilateral or more polygon.

  It is convenient to add an additional function if the outer shape of the sensor is a polygon larger than a square.

  As the outer shape of the pressure sensor, various shapes can be selected according to the type and form of the pressure detecting element used for the pressure sensor, the purpose of measurement, the condition of the living body to be measured, and the like.

  The measurement of pulsation is a concern for many noises. As a matter of course, it is also useful to selectively use noise suppression means conventionally considered in heart sound measurement for this noise removal.

  FIG. 5 is a diagram for explaining an example of a pressure sensor for measuring the pulsation of the biological reaction recording apparatus as an embodiment of the present invention, in which the outer shape of the sensor is a quadrangle.

  In FIG. 5, reference numeral 201b is a pressure sensor, 251a to 251c, 252a to 252c, 253a to 253c, 254a to 254f are pressure sensor parts for detecting the pulsation of a living body, 258 is a substrate, and 255 is an outer wall of the outer periphery of the pressure sensor. It is.

  The pressure sensors 253a to 253c can measure pulsations at corresponding positions. The pressure sensor units 254a to 254f can detect the pressure at the position, and for example, can acquire information supplementing the pressure information detected by the pressure sensor units 253a to 253c.

  The pressure sensor for detecting a pressure change in the present invention requires a specially considered condition as known in signal amplification, noise processing, and the like because the living body to be measured is a living body. Sensors that are widely used in various fields are required for medical use, even if the form is different, such as piezoelectric elements that use piezoelectric phenomena in sensors and electrostatic types that use capacitance change between electrodes. It can be used in such a way as to satisfy the conditions, and in this way, many pressure sensing element and displacement sensing element technologies can be used, and a highly reliable and suitable medical pressure sensor can be realized at low cost. can do.

  The pressure sensor as an embodiment of the present invention illustrated in FIGS. 4 and 5 is not limited to this. For example, the number of pressure detection elements arranged two-dimensionally is assumed to be m and n as integers. , M × n, and 5 × 9 or 9 × 15 pressure detectors or pressure detectors are arranged in an elliptical shape with a short axis of 1 cm and a long axis of 3 cm, for example, between the human ribs. This makes it possible to accurately measure the apical pulsation of a person with a conspicuous rib, and to enable many variations. The two-dimensional arrangement of the pressure detection element or pressure detection unit of the pressure sensor according to the present invention is not limited to the measurement of the pulsation diagram, but accurately detects the movement of the heart that performs complex movements including twisting movement. It can be grasped and has a great effect of enabling a correct diagnosis.

  FIGS. 6 to 9 simultaneously measured the apex rhythm diagram of the living body to be measured on the left side lying on the bed in a normal hospital room using the biological reaction recording apparatus as an embodiment of the present invention. It is an example of the heart machine diagram shown with the electrocardiogram, the heart sound diagram, and the first derivative curve of the apex rhythm diagram.

  6 to 9, reference numerals 500, 510, 520, and 530 are heart mechanisms, 502, 512, 522, and 532 are apex rhythms, 503, 513, 523, and 533 are heart sounds, and 504, 514, 524, and 534 Is the electrocardiogram, 501, 511, 521, 531 are the first derivative curves of the apex rhythm diagrams 502, 512, 522, 532, 5011 is the isovolumetric peak of the first derivative curve 501, and 5013 is the rapid inflow wave (3 Corresponding to the sound), the peak of the primary differential curve 501 corresponding to the left atrial contraction wave (corresponding to the four sounds), and 5111 the peak of the isovolumetric contraction of the primary differential curve 511. 5113 is almost unknown, but the peak of the first derivative curve 511 corresponding to the rapid inflow wave, and 5114 is the peak of the first derivative curve 511 corresponding to the left atrial contraction wave. 5211 is the peak of the isovolumetric contraction phase of the primary differential curve 521, 5213 is the peak of the primary differential curve 521 corresponding to the rapid inflow wave, 5214 is the peak of the primary differential curve 521 corresponding to the left atrial contraction wave, 5311 is The peak of the isobaric systole of the primary differential curve 531, 5313 is the peak of the primary differential curve 531 corresponding to the rapid inflow wave, 5314 is the peak of the primary differential curve 531 corresponding to the left atrial contraction wave, 5031, 5131, 5231, 5331 is one sound, 5032, 5132, 5232 and 5332 are two sounds, 5333 is a state where three and four sounds are superimposed, 5034 and 5134 are four sounds, and 5041, 5141, 5241 and 5341 are QRS waves.

  6 to 9, the horizontal axis is the time axis common to each graph (figure), and the numbers on the horizontal axis are point values when the start point (not shown) is 0 seconds and 10 seconds is 12000 points. The vertical axis is a standard value of amplitude (intensity), and the relative value indicating the standard of detection intensity for electrocardiograms and electrocardiograms, and the maximum value for 10 seconds normalized to 1000 for apex rhythms The numerical value and the first derivative curve are differentiated values.

  One of the features of the graph of FIG. 6 is that the first derivative curve peak 5011 corresponding to the isovolumetric systole is high and the first derivative curve peak 5013 corresponding to the rapid inflow wave is low, corresponding to the left atrial contraction wave. The peak 5014 of the first derivative curve is low.

  One of the features of the graph of FIG. 7 is that the peak 5111 of the first derivative curve corresponding to the isovolumetric systole is high, and the peak 5113 of the first derivative curve corresponding to the rapid inflow wave is hardly understood. That is, the peak 5114 of the primary differential curve corresponding to is about 40% of the peak 5111.

  One of the characteristics of the graph of FIG. 8 is that the peak 5213 of the first derivative curve corresponding to the rapid inflow wave and the peak 5214 of the first derivative curve corresponding to the left atrial contraction wave are more than the peak 5211 corresponding to the isovolumetric systole. It is expensive.

  One of the features of the graph of FIG. 9 is that the peak 5313 of the primary differential curve corresponding to the rapid inflow wave is higher than the peak 5311 corresponding to the isovolumetric systole, and the peak of the primary differential curve corresponding to the left atrial contraction wave. 5314 is not higher than the peak 5311 corresponding to the isovolumetric systole, but about half of it. When it becomes severe, the left atrial contraction wave becomes inconspicuous and becomes a rapid inflow wave only.

  FIG. 6 shows a case of a healthy person capable of intense sports, FIG. 7 shows a case of a patient with normal left ventricular contraction but impaired expansion, and FIG. FIG. 9 in the case of a patient who has a patient is an example of a severe patient, and the data in the case of a patient who cannot move even worse than the case of FIG. More specifically, FIG. 7 shows data of a patient who cannot perform intense sports but can go up and down stairs, go out and travel, and FIG. 8 shows data of a patient who can walk only slowly. Is the data of patients who cannot walk without leaving the bed to the toilet.

  FIGS. 10 to 16 are diagrams for explaining examples of temporal changes in heartbeat diagrams measured using a biological reaction recording apparatus as an embodiment of the present invention. FIGS. FIGS. 13, 13 and 14 are heart diagrams of the same measured living body different from the measured living body of FIGS. 10 to 12, and FIGS. 15 and 16 are measured living bodies of FIGS. 10 to 12 and FIGS. It is a heartbeat figure of the same to-be-measured living body different from FIG.

  10 to 16, reference numerals 554, 558, 562, 566, 570, 574, 578 are electrocardiograms, 553, 557, 561, 565, 569, 573, 577 are electrocardiograms, 552, 556, 560, 564, 568. , 572, 576 are apex rhythm diagrams, 551, 555, 559, 563, 567, 571, 575 are primary differential curves of the apex rhythm diagrams, and A1 to A5 are A waves (left atrial contraction wave) of each apex rhythm diagram. ), 5511, 5551, 5591, 5631, and 5671 are the extreme values of the differential waveform in the isovolumetric contraction period, and 5514, 5554, 5594, 5634, and 5684 are the extreme values of the A wave.

  10 is a heart diagram when the measured living body has a blood pressure of 230/130 mmHg, and FIG. 11 is a heart mechanism diagram when the blood pressure is 200/110 mmHg by administering a hypotensive drug to the measured living body of FIG. FIG. 12 is a heartbeat diagram showing a blood pressure of 160/90 mmHg after treatment of the living body of FIG. 10 after treatment, and a better medical condition. Measurement after 8 days from the measurement of FIG. It is data.

  10 to 12, the A wave of the apex rhythm is clearly noticeable in FIG. 10, is lower than FIG. 10 in FIG. 11, and is hardly noticeable in FIG. This is a phenomenon suggesting that left ventricular diastolic dysfunction has improved. It can be seen that the load on the heart is reduced because the blood pressure actually decreased from 230/130 mmHg to 200/110 mmHg and further to 160/90 mmHg as described above. The A wave indicated by reference numeral A3 is an example that is difficult to understand in FIG. 12, but it may be difficult to understand where to take. Even in such a case, if a differential waveform is used as shown in FIG.

  FIG. 13 is a heartbeat diagram in a state where the measured living body is bad, and FIG. 14 is a heartbeat diagram in a state where the medical condition of the measured biological body in FIG. 13 is improved as a result of treatment, and is measurement data 14 days after the measurement in FIG. . This is an example of a left ventricular diastolic disorder that can be said to be similar to FIGS. 10 to 12, and is a phenomenon suggesting that the diastolic dysfunction of the left ventricle is improved even if the A wave is reduced. In the blood pressure data, the blood pressure is lowered from 190/110 mmHg to 160/85 mmHg by administering a blood pressure lowering agent.

  10 to 12, with respect to extreme values (reference numeral 5511 in FIG. 10, reference numeral 5551 in FIG. 11, reference numeral 5591 in FIG. 12, reference numeral 5631 in FIG. 13, reference numeral 5671 in FIG. 14) with differential waveforms in the differential waveform. The left ventricular end-diastolic situation is grasped by looking at the ratio of the extreme values of the A wave (reference numeral 5514 in FIG. 10, reference numeral 5554 in FIG. 11, reference numeral 5594 in FIG. 12, reference numeral 5634 in FIG. 13, reference numeral 5574 in FIG. 14). it can. If the ratio of the extreme value of the A wave decreases, it is suggested that the load in the end diastole of the left ventricle is reduced.

  15 is a heart diagram in a state where the measured living body is in a bad state, and FIG. 16 is a heart mechanism diagram in a state where the measured biological body in FIG. 15 is improved as a result of treatment, and measurement data after about 6 months from the measurement in FIG. It is. Reference numerals d1 to d9, d31 to d3, and d91 are points for explaining examples of the characteristics of the primary differential waveform of the apex rhythm diagram.

  In any case, there is a characteristic in the temporal change of the peak shape of the pulsation chart, and in FIG. 15, considering the A wave, the d1 point of the differential waveform (the maximum point of the differential value) to the d2 point (A point where the differential value is almost zero) (In the process from the d1 point to the d2 point, the differential value may fall and then rise again, and then fall to the d2 point), and then to the d3 point (minimum differential value point) It goes down in a straight line, then rises from d3 point to d31 point where the differential value is zero, and is almost horizontally from d31 point to d32 point (although there are some fluctuations due to noise and other circumstances, it is roughly horizontal) After a lapse, it goes from d32 point to d33 point (point corresponding to d1 point of the next cycle) and then repeats this. In FIG. 16, from d4 point (maximum point of differential value) to d5 Until the point (the point where the differential value is almost zero) After moving down linearly and moving horizontally until d6 point, it dropped almost linearly from d6 point to d7 point (minimum differential value) and then d8 point (point where the differential value is almost zero). It moves linearly (the differential value goes up and down past the zero point, but it is a fine change, which can be said to be almost linear) and then moves horizontally until d9, and d91 (the next cycle) (Which corresponds to d4 point) and then repeat this process.

  15 shows an example of a heart failure state in which the left ventricular contractility (left ventricular ejection fraction) is 40%, and FIG. 16 shows a left ventricular ejection fraction when a heart failure therapeutic agent is administered to the patient in the state of FIG. This is an example in which the state is improved to 60%.

  17, 18 and 19 are diagrams for explaining an example of the pulsation amplitude distribution as an embodiment of the present invention. FIG. 17 is a diagram for explaining the pressure detection position of the pressure sensor. P1 to P9 are pressures. 18 and 19 are diagrams showing examples of typical patterns of the pulsation amplitude distribution measured by the pressure sensor shown in FIG. 17 as cross-sectional views at predetermined positions of a three-dimensional display figure. is there. 18 and 19, the horizontal axis of each figure (graph) indicates the pressure detection position of FIG. 17, and the vertical axis indicates the magnitude of the pulsation amplitude at each pressure detection position indicated on the horizontal axis. It is shown as data.

  As a typical pattern of the pulsation amplitude distribution, at least the type shown in FIG. 18A (hereinafter also referred to as pattern A) at the positions of the pressure detection positions P4, P5, and P6 in FIG. There are types shown in B) (hereinafter also referred to as pattern B).

  More specifically, when apex pulsation is measured with a pressure sensor in which a large number of pressure detection elements or pressure detection units are arranged at positions indicated by P1 to P9 in FIG. As shown in FIG. 19, the amplitude distribution at the pressure detection positions P1 to P3, P4 to P6, and P7 to P9 shown in FIG. As shown in FIG. 17, the amplitude distribution at the pressure detection positions P1 to P3 and P7 to P9 in FIG. 17 is different from the amplitude distribution at P4 to P6, and the amplitude at the pressure detection position P5 in FIG. , P4, P6, and P8 are smaller than the amplitude at the pressure detection position P5 but larger than the amplitudes at the pressure detection positions P1, P3, P7, and P9.

  The amplitude distribution of the pulsation of the measurement subject whose heart condition is not healthy has many patterns A, and the amplitude distribution of the pulsation of the measurement subject whose heart condition is normal has many patterns B. However, depending on the medical condition, the amplitude distribution of pattern B may be exhibited even in the case of a non-healthy person. In such a case, a correct diagnosis can be performed by combining the apex pulsation diagram, blood pressure, and the amplitude distribution of pulsations. As is clear from this example, the actual medical condition can be accurately determined by diagnosing the measurement data of only the ECG, ECG, and apex rhythm with the measurement data of the pulsation amplitude distribution and intensity distribution. Can be diagnosed.

  The pulsation amplitude distribution shown in FIGS. 18 and 19 is data at a certain moment. In particular, the maximum amplitude in the case of pattern B (the amplitude at the pressure detection position P5 in FIG. 19) moves from P5 to another position during one beat.

  Furthermore, the detection of the intensity of the pulsation in the present invention is information that helps to estimate the momentum of the heart.

  The apex rhythm diagram is said to provide a lot of information on the health condition of the subject, but as described above, conventionally, it is possible to obtain biological information in the state of the subject as it is. There wasn't. In other words, in the past, the measurement was not only a major problem of high measurement costs, but also in a constrained environment such as a soundproof room, with the subject in a tense state or with special attention. There wasn't. For this reason, it was considered that the degree useful for medical treatment was very low.

  The present invention not only solves the big problem of high measurement cost, but also makes it possible to obtain biological information as it is.

  As can be seen in each of the above examples, the apex rhythm diagram as an example of the biological information recorded by the present invention provides a lot of information regarding the health condition of the subject.

  It is important to appropriately extract information necessary for medical care from this biological information. However, unfortunately, an algorithm for appropriately detecting and utilizing the information has not been established yet. The inventor of the present application has further studied how this information can be extracted and utilized, found a biometric information extraction algorithm, and succeeded in realizing a biometric information recording method and biometric information recording apparatus using the algorithm. did.

  Hereinafter, the present invention will be described in more detail based on examples.

  In order to avoid duplication of explanation, as described above, as a measuring means used when implementing the biological information recording method and the biological information recording apparatus of the present invention, the motion of the heart is detected as a change in pressure using a pressure sensor, as described above. For example, the measurement means for obtaining the apex rhythm diagram as described above or described below will be described. As a result of the examination by the inventors of the present invention, the apex rhythm diagram is measured using an ultrasonic diagnostic apparatus. It turns out that it is also possible. Therefore, the description of the apex rhythm diagram of the present invention also applies to the biometric information recording method and the biometric information recording apparatus that measure the apex rhythm diagram using an ultrasonic diagnostic apparatus.

  FIG. 20 is a block diagram for explaining the flow of measurement, illustrating a method for measuring the apex pulsation diagram using the apex rhythm diagram measuring device as an example of the biological reaction recording apparatus of the present invention. In this way, the apex pulsogram measuring instrument as an example of the biological reaction recording apparatus of the present invention will be substantially described together, but the measuring instrument can be configured by using only a part of this, and all of them can be used. The measuring instrument can also be configured, and further, a measuring instrument can be configured by combining other means in part or in whole.

In FIG. 20, symbol Y1 indicates an operation of pressing a start button, and Y2 indicates an operation of inputting subject information. Patient information is information that includes information necessary for measurement and diagnosis.
For example,
(Z-1) Input subject's disease information Z-1A: Input by subject.
Input from the patient or subject.
Objective: Self-management, preventive. Enter the necessary information such as age, gender, height, weight, blood pressure, medical history, etc.
Z-1B: Enter the presence or absence of an input pacemaker by a specialist, medication information, arrhythmia, presence or absence of heart failure, and the like.

  In the case of certain types of abnormal electrocardiograms, the electrocardiogram is examined because the left ventricular contraction may change regardless of the original left ventricular myocardial function.

  In Y3, the procedure is determined based on the presence or absence of a pacemaker. In this example, a subject whose pacemaker is not operating is set as a measurement target.

  In Y4, the procedure is determined based on the presence or absence of arrhythmia. For example, tachycardiac atrial fibrillation, ventricular tachycardia, paroxysmal supraventricular tachycardia, and advanced atrioventricular block are measured. For example, in the case of atrial fibrillation, measurement is performed when the interval between the QRS wave included in the apex rhythm waveform to be measured and the QRS wave immediately before it is 800 msec or more. In addition, in the case of repetitive extrasystoles or two-stage pulse, it is excluded from the measurement target. The case where at least a constant arrhythmia continues three or more times is the measurement object.

In Y5, the determination procedure based on the presence / absence of conduction failure is performed, for example, except for the complete left leg block.

  At Y6, the presence / absence of thoracotomy is entered.

  In Y7, the medication status of the internal medicine and injection is input.

  At Y8, the presence or absence of heart failure is input.

  Start measurement at Y9.

  The measurement time is set appropriately and can be selected. For example, the measurement time can be selected as 10 seconds, 20 seconds, 30 seconds, etc., so that it can correspond to the breathing state of the subject.

  The measurement conditions are as follows. Basically, record in the left half-side position. Record in semi-expiratory position with tension released. In the method of recording without resting while still breathing, the baseline of the apex rhythm may be distorted and evaluation may be difficult. If recorded in the deep expiratory position (at the time of exhaling), it may be difficult to evaluate because the muscle tone tends to increase and the patient tends to hold the breath. It is known that holding the breath will cause changes in blood pressure and heart rate, which is different from the state at rest, which may be an unfavorable situation in the deep expiratory position. In the data shown below, as a general rule, the body position was set to the left half-sided position, and breathing was gently stopped in a semi-expiratory position, and recording was performed for 10 seconds.

  The details of the measurement performed at Y9 will be described below including the internal operation of the measuring instrument.

  In the measurement, the patient's apex rhythm diagram is recorded using a measuring instrument in the outpatient office and general hospital room. As a general rule, attach ECG conductors to the right and left limbs of the subject, record the ECG with the second lead of the standard limb lead, and in principle, attach a phonometer microphone near the left edge of the middle intercostal sternum , Place the subject in the left semi-recumbent position, the doctor touches the apex heartbeat, confirms the location with the strongest heartbeat, applies the sensor to the site, and records the apex heartbeat diagram in semi-expiratory position as a rule . All of the above operation record measurements are performed by one doctor, and preparations are made for measurement of electrocardiograms, phonocardiograms, and apex rhythms.

  First, measurement data is captured in synchronization with the waveform (QRS wave) of the electrocardiogram.

  The measurement data consists of three items: an electrocardiogram, a heart sound diagram, and an apex rhythm diagram. If necessary, jugular vein waves, parasternal pulsation waves, and hepatic pulsation waves can be recorded. For each measurement waveform measurement, the position where the sensor and the sensor are applied can be optimally selected.

  Electrocardiogram and phonocardiogram information is useful for analyzing apex rhythms. For example, it is necessary to identify the R wave of the electrocardiogram, and this can be done by a known method. Information on 1st, 2nd, 3rd, and 4th sounds in the phonocardiogram may be useful. These identifications can also be performed by a known method. In addition, the two-tone aortic component of the phonocardiogram is not necessarily limited to a known method using a carotid artery wave, and a signal can be obtained without performing measurement by applying a sensor to the carotid artery.

  It is also possible to embed an electrocardiogram or electrocardiogram sensor in the apex rhythm sensor. In this case, a remarkable effect can be brought about, for example, the operation is greatly simplified.

  After taking the measurement data, remove the data noise. For example, a myoelectric filter, a ham filter, a drift removing means, etc. can be used.

Measurement Example 1
The feature points of the apex rhythm diagram will be described. FIG. 21 is an example of the apex rhythm diagram of a subject with normal left ventricular function measured using the apex rhythm measuring instrument of the present invention, and the symbol R represents the apex of the electrocardiogram QRS wave. Reference numeral 1 is a heart sound and 1 sound, and 2 is a heart sound and 2 sounds. Reference symbol X1 is an electrocardiogram, X2 is a heart sound diagram, X3 is a curve representing an apex rhythm diagram, and X4 is a primary differential curve obtained by differentiating the curve X3 of the apex rhythm diagram with respect to a horizontal axis.

  With reference to FIG. 21, the characteristic value in the apex rhythm waveform which interprets measurement data is demonstrated. First, a positive wave due to left atrial contraction is observed. This is A wave. Let the positive extreme value be A point. When the A wave does not have a positive extreme value and rises continuously and reaches a later-described C point, the C point is regarded as the A point. In the phonocardiogram, four sounds generated by left atrial contraction may be recognized. Point A is recognized almost simultaneously with the four sounds, and exists before the QRS wave. Next, a rising point C is generated. This is the starting point of the left ventricular systolic wave (E wave) and is observed near the apex of the electrocardiogram QRS wave. The E wave rises sharply from the point C and forms a positive extreme value E point in the early contraction period. The point E substantially coincides with the left ventricular ejection start point. The period from point C to point E corresponds to the isovolumetric systole. Then, it descends slowly, rises again in the late contraction period, and shows a positive extreme value S point. The S point exists immediately before the second sound. Point S is the left ventricular expansion start point. Immediately after the S point, two sounds are generated, and then suddenly descends to the O point. The point O exists in the early diastole and is usually the lowest point (negative extreme value) in the apex rhythm diagram. Temporally, it exists near the time of mitral valve opening. A relatively steep ascending wave is observed from point O. This ascending wave is referred to as a rapid inflow wave (F wave). Let the vertex be F point. The F wave is caused by a rapid inflow of blood from the left atrium in the early stage of left ventricular dilation into the left ventricle. The end of the F wave almost coincides with the three sounds in time. Thereafter, a gentle ascending wave due to the slow inflow of blood from the left atrium to the left ventricle in the middle stage of left ventricular expansion is recognized, leading to an A wave.

  The positive peak values of the A wave, the E wave, and the F wave in the primary differential waveform X4 of the apex rhythm diagram are defined as a point, e point, and f point, respectively. X5 and X6 both coincide with the E point and the S point in time at the point where the differential value is zero.

  The apex rhythm diagram of FIG. 21 is a graph in which each of the points appears relatively clearly, but depending on the subject or the size and shape of the sensor, each feature point (point A, point C, point E) , S point, O point, F point) may appear indistinctly. Even in such a case, the medical professional may be able to identify each point from experience in the medical field and others. An expert system using this expert judgment method is applied to an apex rhythm meter as an example of the biological reaction recording device of the present invention, or an actual measurement measured by the apex rhythm meter of the present invention The use of the data in combination with the judgment by the medical professional will further enhance the effect of the present invention.

  The selected waveform is defined as one waveform from point A to immediately before the next point A. In principle, the waveform having the maximum amplitude is selected from the recorded waveforms, and the total amplitude of the waveform is normalized to 1000 points and measured. However, the waveform must be smooth and free from abnormal vibrations. In order to define the C point first, the waveform when the C point of the measured waveform and the C point of the immediately preceding waveform are substantially the same (normalized and less than 50 points) is selected. The amplitude is preferably 400 points as an actual measured value before normalizing the data. One reason is that small vibrations other than the apex rhythm may be mixed. Even if the vibration is small, if the amplitude of the apex rhythm diagram is small, the vibration is easily emphasized. In some cases, a plurality of continuous waveforms in an arbitrary section measured and stored may be normalized and used for measurement. Also, depending on the situation, using a plurality of non-consecutive waveforms is also effective for correct diagnosis of data. In the figure, the horizontal axis shows the value obtained by dividing 12000 by 12000 as 1, and the vertical axis shows the value obtained by dividing the maximum and minimum values of one waveform by 1000 in principle in the case of apex rhythm. The ECG and ECG are relative values as a guide.

  FIG. 21 is an example of a 19-year-old male subject with normal left ventricular function. The measurement procedure will be described with reference to FIG. First, point C in the apex rhythm diagram waveform is detected. A vertical line is dropped from R of the electrocardiogram, and the negative extreme value (the point where the first-order differential waveform turns from-to +) for 20 msec before and after the point where the vertical line and the apex rhythm waveform cross each other is defined as C point. To do. When there is no negative extreme value in the above 40 msec, the point where the perpendicular line and the apex rhythm diagram waveform intersect is defined as C point. A positive extreme value (a point at which the first-order differential waveform turns from + to-) less than 160 msec before point C is defined as point A. As shown in the example of FIG. 22, when the A wave continuously rises up to the point C and there is no positive extreme value (the first derivative waveform of the apex rhythm diagram is positive up to the point C), the point C is designated as the point A. I reckon.

A positive extreme value (a point at which the first-order differential waveform turns from + to −) at a point less than 150 msec from point C in the apex rhythm diagram waveform is defined as point E. When the E point is not recognized less than 150 msec and a positive extreme value is recognized only at 150 msec or more, the extreme value is set as the P point. Usually, it is less than 125 msec from point C to point E. If the point C to point E is less than 125 to 150 msec, the left ventricular contractility may be reduced, or there may be moderate or higher left ventricular hypertrophy, which is a state of caution.
Normal when CE time (time from point C to point E) <125 msec. That is, it can be said that this parameter is in a normal range.
125 ≦ CE time <150 msec is a boundary region and is a medical condition requiring attention. The presence of point P is clearly an abnormal finding. That is, there is a high possibility that left ventricular contractility is reduced or that left ventricular hypertrophy is moderate or higher.

  The positive extreme value that exists before the second sound and is closest to the second sound of less than 50 msec up to the second sound is defined as the S point. Positive extreme values that exist before two sounds and are separated by 50 msec or more up to two sounds are not treated as S points.

  The first negative extreme value of the apex rhythm diagram is set as the O point after 30 msec from the second sound. The minimum value 200 msec or more away from the two sounds is not the O point.

  2-O time (time from 2 sounds to point O) <150 msec is a normal value. An abnormal value is 150 msec <2-O time <200 msec.

  A positive extreme value existing after the O point and less than 100 msec from the O point is defined as the F point. A positive extreme value that is 100 msec or more away from the O point after the O point is not treated as the F point.

  Depending on the difference between the subjects and the health condition, all the feature points may be present or not all.

  In FIG. 21, point A, point E, point S, point O, and point F can be identified. Point A is less than 300 points. C point is less than 300 points. There is an E point less than 125 msec from the C point. Presents a descending wave from point E. A recurrent ascending wave having a vertex S in less than 50 msec before the second sound is recognized. A descending wave from the point S is shown. The O point is recognized from 2 sounds to less than 150 msec. The F point is recognized within 100 msec from the O point. The F point is lower than the C point. Point F indicates an overshoot.

  Overshooting is a phenomenon in which, after the rising wave reaches the peak, it immediately falls downward immediately and then rises again.

  This finding is observed in an example of a left ventricular myocardial extensibility (high compliance) normal left ventricular dilatability, and also in the case of an increase in left ventricular dilatation initial load. In the differential waveform X4, the interval between X5 and X6 being 30% or more compared to the interval between the C point and the O point indicates that the left ventricular function is maintained. This is supported by the fact that it was normal as evaluated by Doppler method on echocardiogram. a is less than ¼ of e, and is data indicating that the left atrial contractile force at the end diastole is not abnormally increased. f is less than ½ of e, and is data indicating that the left ventricular load at the initial stage of expansion has not increased. It is a normal finding that a is smaller than f.

  In the first derivative waveform by the time of the apex rhythm diagram, the value of the point a is normal when the value of the point e is less than a quarter, and the boundary region, that is, a caution is required from a quarter or more to less than a half, More than one half is considered abnormal. In addition, the value of the f point is less than half of the value of the e point, normal is more than one half to less than two thirds, and a boundary region, that is, attention is required, and more than two thirds is abnormal. It is normal that a is equal to or smaller than f. It is assumed that a is greater than f.

In FIG. 21, in the differentiated waveform X4, it suddenly reached a straight line from point e (maximum point of the differential value) to point X5 (point where the differential value is almost zero), and after passing through the negative part, it moved almost horizontally. After that, it once showed a positive part and reached point X6 (a point where the differential value was almost zero), then dropped almost linearly from the point X6 to the point L4 (minimum point of the differential value), then rose almost linearly, and then increased to L5 ( The point where the differential value is approximately zero) reaches the point f. Reference symbol L1 is a line segment connecting point e and X5 with a straight line, L2 is a line segment connecting X5 and X6 with a straight line, and L3 is a line segment connecting X6 and L4 with a straight line.
FIG. 23 shows this state entered in FIG.

  On the other hand, FIG. 24 is obtained by adding the same consideration as FIG. 23 to the differential waveform of the apex rhythm diagram of a subject having a symptom different from that in FIG. 24, X31 is an electrocardiogram, X32 is a heart sound diagram, X33 is an apex rhythm diagram, X34 is a differential waveform obtained by differentiating the apex rhythm diagram X33 with respect to time, L8 and L10 are 0 points of the differential waveform X34, and L9 is a differential value. , L6 is a line segment connecting point e and L8 with a straight line, and L7 is a line segment connecting L8 and L9 with a straight line.

  In the differential waveform X34, after reaching from the point e to the point L8 (a point where the differential value is almost zero), it is almost linear, as shown in the case of X5-X6 in FIG. It goes down linearly to the point and then goes up linearly to reach point L10.

  FIG. 23 shows data on subjects with normal cardiac function as described above, and FIG. 24 shows data on subjects with reduced left ventricular contractility. Comparing FIG. 23 and FIG. 24, in the differential waveform, there is a section in which the waveform gradually changes from the point e in FIG. That is, L2 exists. Thus, by examining the differential waveform X4 of FIG. 23, it becomes a feature point that supports the existence of the E point and the S point in the apex rhythm diagram, and suggests that the contractility is generally normal. On the other hand, in the differential waveform X34 in FIG. 24, there is no section that changes horizontally from the point e to the point L9. This indicates that there is no line segment corresponding to the line segment L2 in FIG. This is a characteristic finding that suggests a contraction disorder.

  Next, attention is paid to the horizontal axis (time axis) of the first-order differential waveform in FIG.

  The section from the S point to the O point, that is, the section substantially corresponding to the isocapacity expansion period, corresponds to the section of X6 and L5 (X6-L5 section) in the primary differential waveform. In the diastole, it is considered that the better the extensibility of the left ventricular myocardium, the more relaxed from the early stage. That is, the relaxation peak appears to appear early. In the apex rhythm diagram, relaxation starts from the S point. It can be said that the L4 point indicating the maximum change rate in the first-order differential waveform indicating the change rate of the relaxation is located in the first half of the X6-L5 interval indicates that the relaxation of the normal example described above occurs early. As described above, the diastolic kinetics in the isovolumetric diastole can be determined characteristically and easily.

  As described above, the biological reaction recording apparatus and the biological reaction recording method of the present invention are not limited to healthy persons who can be taken to a “soundproof room” or those with mild symptoms, but “ It is possible to measure the apex rhythm of critically ill patients who cannot be taken into the measurement environment such as `` room '' at the bedside, and has high confidence that it is medically consistent with the symptoms determined separately from the present invention. It can be seen that the health status of the subject can be determined by sex.

  FIG. 25 is a diagram for explaining the division of the systole and diastole of the cardiac cycle.

  The apex rhythm is useful for evaluating the left heart system, especially the left ventricular function. By evaluating the time phase and height of each feature point (A point, C point, E point, S point, O point, F point, a point, e point, f point) of the measurement example, the left ventricular function It can be seen that can be considered in more detail. Among them, the S point seems to be particularly important. That is, it is one of the features of the rhythmic left ventricular movement that is recorded when the left ventricle finishes contracting and begins to relax. It is thought that this occurs when many left ventricular cardiomyocytes synchronously begin to relax after the end of contraction. Therefore, when there is a certain amount of myocardial mass abnormality in the left ventricular myocardium (moderate hypertrophy, complex arrangement, fibrosis, degeneration, etc.), the S point is unlikely to occur. From such a viewpoint, the point S is considered to be an index of left ventricular diastolic disorder. If the S point is present, the expandability is expected to be generally normal. In addition, left ventricular dysfunction is said to be preceded by diastolic dysfunction and then contraction dysfunction. That is, diastolic disorders can occur alone, but contraction disorders can be combined. On the other hand, a contraction disorder always has an expansion disorder. If the S point does not exist, there is a possibility that an expansion disorder exists, and at the same time, a contraction disorder is suspected. Therefore, the point S is considered to be a feature point that should be first noted when evaluating the left ventricular function. The S point is the start point of a section named by Wiggers as a prototype phase (PD). PD exists just before the isovolumetric diastole starting from the time of aortic valve closure. That is, PD is from the point S to the aortic valve closing time. This is the point where the left ventricular myocardial tension begins to decrease. At this point, the length of the left ventricular myocardium is the shortest and has not yet extended. Based on past measurements, the PD interval is said to be an average of 39 msec. Therefore, the present inventor divided the group into a normal group and an abnormal group at 50 msec.

  FIG. 25 shows the above hypothesis with another person's hypothesis.

  Measurement Example 2 FIG. 26 is an example of a 52 year old male with normal left ventricular function. C point E point S point O point F point has been identified respectively. A wave showing a slightly upwardly convex waveform is recognized, and ascending to C point, and has no positive extreme value, A point and C point coincide. The time from point C to point E is less than 125 msec and is determined to be normal.

  In the differentiated waveform X10, the X11-X12 interval is 30% or more of the C—O interval, which is an indicator that the left ventricular function is maintained. Point F does not show a clear overshoot. This suggests that the extensibility of the left ventricular myocardium is lower than that in the example of FIG. A decrease in the extensibility of the left ventricular myocardium due to aging is considered to be a physiological normal finding. a is less than ¼ of e, and is data indicating that the left atrial contractile force at the end diastole is not abnormally increased. f is less than 1/2 of e, and is data indicating that the left ventricular load in the initial stage of expansion has not increased. It is a normal finding that a is smaller than f.

Measurement Example 3
FIG. 27 is an example of a 25-year-old woman who has normal left ventricular function. A point C point E point S point O point F point has been identified respectively. A point is 320 points. C point is 320 points. This is seen in young patients with normal left ventricular contractility and particularly good dilatability. This is because the point O indicates a low value, the F wave is steep, and the points A and C relatively indicate high values. There is an E point less than 125 msec from the C point. Presents a descending wave from point E. A recurrent ascending wave having a vertex S at less than 50 msec from two sounds is recognized. A descending wave from the point S is shown. The O point is recognized from 2 sounds to less than 150 msec. The F point is recognized within 100 msec from the O point. The F point is lower than the C point. Point F shows a slight overshoot. Similar to FIG. 21, this finding is often observed in young people with normal left ventricular function. It represents the flexibility of the left ventricle. In the differential waveform X16, the X17-X18 interval is 40% or more of the C—O interval, and thus is an indicator that the left ventricular function is maintained. a is less than ¼ of e, and is data indicating that the left atrial contractile force at the end diastole is not abnormally increased. f is less than ½ of e, and is data indicating that the left ventricular load at the initial stage of expansion has not increased. It is a normal finding that a is smaller than f.

Measurement Example 4
FIG. 28 is an apex rhythm diagram of a 71-year-old woman with no history of heart disease. A point, C point, E point, S point, and O point can be identified, but F point is not allowed. This indicates that the extensibility of the left ventricular myocardium is reduced. This is a decrease in left ventricular dilatability. This finding is considered to be physiological according to age with age. In addition, from point C to point E is less than 125 to 150 msec, the left ventricular contractility may be reduced, or there may be moderate or higher left ventricular hypertrophy, which is a state of caution. In the differential waveform X22, the X23-X24 interval is 30% or more of the C-O interval, and thus is an indicator that the left ventricular function is maintained. Also, since the value of point a is between one-quarter or more and less than one-half of the value of point e, it seems to be a left ventricular end-diastolic load, and it is a boundary area and needs attention. Since f does not exist, comparison with a is not possible.

Measurement Example 5
FIG. 29 is an example of a 30 year old woman with normal left ventricular function.
Both points A and C are over 300 points. This is seen in young patients with normal left ventricular contractility and particularly good dilatability. This is because the point O indicates a low value, the F wave is steep, and the points A and C relatively indicate high values. The low value of point a in the first derivative curve is an observation indicating that left atrial contraction is not enhanced. Further, it is recognized that the point E is sharpened relatively early, and a bimodal waveform (arrow) is recognized in the vicinity of the point E. This may be due to the effect of counterclockwise rotation of the left ventricle or the effect of transmission of a single sound vibration. This finding alone cannot be determined as an abnormal finding. It is common in relatively young subjects with normal left ventricular function, and may also be present in patients with severe anemia, sympathetic tone, hyperthyroidism, and mitral stenosis.

Measurement Example 6
FIG. 30 shows an example of a 70-year-old man with high blood pressure. Point A shows a high value exceeding 300 points. Point C is less than 300 points and in the normal range. The points E and S are normal. From point C to point E is less than 125 to 150 msec, and left ventricular contractility is reduced, or there may be moderate or higher left ventricular hypertrophy, which is a state of caution. The point O is a normal range with less than 150 msec of two sounds. F point cannot be identified. This suggests left ventricular diastolic dysfunction in early diastole. Further, the point A is high and the point a of the first-order differential curve indicates one-half or more of the point e, suggesting end-diastolic left ventricular diastolic dysfunction due to enhancement of left atrial contraction.

  Next, an example of a heart failure state is shown.

Measurement Example 7
FIG. 31 shows an example of a 30-year-old man who suffered from heart failure due to hypertensive heart disease. NYHA heart function classification (New York Heart Association heart function classification), which is forced to rest on the bed and receiving oxygen inhalation and infusion of heart failure treatment drugs, is a record in the 4th state. A point is 490 points, C point is 310 points, and all points are abnormal values.

  A positive extreme value E point is not recognized from C point to less than 150 msec, and a positive extreme value is recognized only at 150 msec or more. Therefore, this positive extreme value is P point. Also, S point is not allowed. There is a high possibility that the small wave (↓) recognized almost coincident with the two sounds is not the S point before the two sounds but the spike wave (notch) in which the vibration of the two sounds propagated. Although the F point is recognized in less than 100 msec from the O point, it is as high as 400 points and higher than the C point (310 points).

  In the first derivative curve, a is at least half of e. This finding means that left atrial contraction at the end of left ventricular end diastole is enhanced. f is greater than e. This finding is a finding that the left ventricular load in the early stage of left ventricular expansion has increased. Based on the above findings, both left ventricular contractility and left ventricular diastolic decline are shown, and this is an example of a severe left ventricular failure state. Further, since there is no S point, the temporal analysis of the differential waveform is not possible.

  The examples shown in FIGS. 8 and 9 are also judged in the same manner, and both the left ventricular contractility and the left ventricular diastolic ability are reduced, which is a serious left ventricular insufficiency state.

Measurement Example 8
FIG. 32 is an example of a 42 year old man diagnosed with dilated cardiomyopathy. It is a record of the state of NYHA heart function classification 4 degrees forced to rest on the bed and oxygen inhalation. The points A and C are both high, and the height of the point a is at least half that of the point e. Suggested increased end-diastolic pressure and enhanced left atrial contraction. The point f is two-thirds or more of the point e. It is shown that there is a load at the beginning and end of diastole. A particularly high f point suggests a severe heart failure state. The point E is clear, but the point S is not allowed. The fact that the S point is not recognized is highly likely to be a case of left ventricular contraction disorder or a case of left ventricular hypertrophy that is moderate or higher although the left ventricular contractility is maintained.

Measurement Example 9
FIG. 33 is an example of a 54 year old male with ischemic cardiomyopathy. This is a record of the condition of emergency hospitalization due to heart failure, forced bed rest and oxygen inhalation (NYHA heart function classification 4 degrees). Both the points A and C are at a high position exceeding 300 points. Point a is less than one-quarter to half of point e, suggesting the possibility of left ventricular end-diastolic load due to enhanced left atrial contraction, and C-point is high. Is suggested to have risen. In the systolic wave, the E point was not recognized, but the P point was recognized, suggesting a decrease in left ventricular contractility or moderate or higher left ventricular hypertrophy. The S point is not recognized, suggesting a decrease in left ventricular contractility or moderate or higher left ventricular hypertrophy. The point rises sharply from the point O to the point F, and the F wave exhibits an overshoot at the point F. Considering the age of 54 years, this overshoot finding suggests an increased load in the early left ventricular dilation. The point f exceeds two-thirds of the point e, suggesting an increase in the load in the early left ventricular expansion. It is an apex rhythm waveform that has abnormal findings in both diastolic and systolic waves and suspects severe heart failure.

Measurement Example 10
FIG. 34 is an example of a 66 year old male with dilated cardiomyopathy. It is a record in a state of NYHA cardiac function classification of 3 degrees in which shortness of breath appears by walking on a flat ground of several meters. The points A and C both exceed 300 points, and the left ventricular load at the end diastole may increase. Point a is between one-fourth and one-half of point e, and there is a possibility of enhanced left atrial contraction. The E wave is rounded and the E point is unclear. There may be decreased left ventricular contractility or left ventricular hypertrophy. S point is not allowed. The fact that the S point is not recognized is highly likely to be a case of left ventricular contraction disorder or a case of left ventricular hypertrophy that is moderate or higher although the left ventricular contractility is maintained. The F point is lower than the C point, but the f point exceeds two-thirds of the e point, and an increase in the left ventricular load at the initial stage of expansion is suspected.

Measurement Example 11
FIG. 35 is an example of a 57 year old male with old apex myocardial infarction. The NYHA heart function classification is 2 degrees, and normal life other than heavy labor is possible. Point A is 300 points, which is a high price. E point is recognized. The notch (↑) immediately before point E can be considered to be the effect of counterclockwise rotation when the left ventricle contracts or the influence of the transmission of a single vibration. The fact that the S point is not recognized is highly likely to be a case of left ventricular contraction disorder or a case of left ventricular hypertrophy that is moderate or higher although the left ventricular contractility is maintained.

  O and F points are recognized, but f is small. a is a quarter to less than a half of e, and there is a possibility of a load due to left atrial contraction. It is an abnormal finding that a is larger than f.

Measurement Example 12
FIG. 36 shows a 75-year-old woman with hypertension, obstructive arteriosclerosis and old apex myocardial infarction. NYHA cardiac function classification is 2 degrees. The point A is recognized in agreement with four clear sounds, the height is over 300 points, and the point a is much more than half of the point e. It suggests left ventricular end-diastolic load due to enhanced left atrial contraction. C point is less than 300 points. In the systolic wave, the point E is not recognized but the point P is recognized. Suspected left ventricular contractility or moderate or higher left ventricular hypertrophy. S point is not recognized, and left ventricular contractility is reduced or left ventricular hypertrophy of moderate or higher is suspected. It is an apex pulsation figure in which left ventricular end-diastolic load and left ventricular contractility are reduced or left ventricular hypertrophy is moderate.

Measurement Example 13
FIG. 37 is an example of a 51 year old woman (NYHA cardiac function classification 2 degrees) with dilated cardiomyopathy. I can do my daily life, but I can't climb the stairs at the station unless I rest on the way. No A wave is observed, and the left ventricular end-diastolic load due to left atrial contraction appears to be small. Further, point E does not exist and point P is recognized. Suggested left ventricular contraction disorder or moderate or higher left ventricular hypertrophy. S point is allowed, but F point is not allowed. This is a decrease in the extensibility of the left ventricular myocardium, suggesting a decrease in left ventricular diastolic ability in the early diastole.

Measurement Example 14
FIG. 38 is an example of a 66 year old woman with dilated cardiomyopathy. In daily life, the NYHA cardiac function classification is 2 degrees, which allows moderate or less effort. Since the A wave continuously rises to the C point, by definition, the A point and the C point are the same. The C point is 150 points or less, and a is also unclear, and it is unlikely that the left ventricular diastolic disorder at the end diastole due to left atrial contraction is low. P point is recognized instead of E point. This finding suggests decreased left ventricular contractility or moderate or higher left ventricular hypertrophy. S point is not allowed. This finding is also suggestive of decreased left ventricular contractility or moderate or higher left ventricular hypertrophy. Both the O point and the F point are small enough to be discriminated. This is a finding of decreased extensibility of the left ventricular myocardium in the early diastole, suggesting decreased left ventricular dilatability.

  Next, two cases of premature myocardial infarction are shown.

Measurement Example 15.
FIG. 39 shows an example of a 69-year-old man with heart failure (compensation period) due to old anterior septal myocardial infarction. The A wave rises gently up to the C point. From the above definition, point A and point C are the same. E point is recognized. Since the S point is not recognized, left ventricular systolic failure or moderate or higher left ventricular hypertrophy is suspected. Barely accept the O point. F wave and F point are not allowed. This suggests a decrease in left ventricular diastolic capacity in the early diastole. Although the e point is observed, neither the a point nor the f point is allowed. It is considered that there is no load due to rapid inflow from the left atrium to the left ventricle in the early diastole. There is also no left ventricular load due to enhanced left atrial contraction at the end of diastole.

Measurement Example 16.
FIG. 40 shows an example of a 68-year-old male with decompensated heart failure due to old anterior septal myocardial infarction. Since the A wave continuously rises to the C point, the A point and the C point are the same. Point A is high, and left ventricular end-diastolic load is suspected. Point a is between one quarter and one half of point e, and there is a possibility of left ventricular load due to enhanced left atrial contraction. Allow point E, but not point S. This is a suspicion of left ventricular systolic failure or moderate or higher left ventricular hypertrophy. The points O and F are clear. The F wave is overshooting. Considering the age of 68 years, this overshoot finding suggests an increased load in the early left ventricular dilation. The point f exceeds two-thirds of the point e, suggesting an increase in the load in the early left ventricular expansion. Although the F point is lower than the C point, the f point is more than two-thirds of the e point, which is a suspicion of an increase in the left ventricular load at the initial stage of expansion. Unlike the example of FIG. 39, it is estimated that this is decompensated heart failure.

  Next, two cases of non-obstructive hypertrophic cardiomyopathy are shown.

Measurement Example 17.
FIG. 41 is a 70 year old male with non-occlusive hypertrophic cardiomyopathy. A suffocation appears during hard work. Both points A and C are 300 points or less. Point a is more than half of point e, suggesting left ventricular dilatation load at the end diastole due to left atrial contraction. There is a notch (↓) that seems to be due to the vibration of one sound. There is no E point and there is a P point. Also, S point is not allowed. The presence of the P point and the absence of the S point suggest a left ventricular contraction disorder or moderate or greater left ventricular hypertrophy. Since the F point is not recognized, left ventricular diastolic dysfunction in the early diastole is suspected.

Measurement Example 18.
FIG. 42 is a 68 year old female with non-occlusive hypertrophic cardiomyopathy. Work other than heavy labor is possible. Since the A wave continuously rises to the C point, the A point and the C point are the same. C point is 300 points or less. Point a is more than half of point e, suggesting left ventricular dilatation load at the end diastole due to left atrial contraction. There is no E point and there is a P point. Also, S point is not allowed. The presence of the P point and the absence of the S point suggest a left ventricular contraction disorder or moderate or greater left ventricular hypertrophy. The F point is low, and left ventricular diastolic dysfunction at the beginning of dilation is suspected.

  Next, four cases of valvular disease are shown.

Measurement Example 19.
FIG. 43 is a 72 year old woman with severe aortic stenosis. Both point A and point C are high, and the point a of the first derivative curve is more than half of point e, suggesting end-diastolic left ventricular diastolic dysfunction due to enhanced left atrial contraction. . A low F point suggests early ventricular left ventricular diastolic dysfunction.

Measurement Example 20
Figure 44 is a 72 year old male with severe aortic regurgitation. Both point A and point C are high, and the point a of the first derivative curve is more than half of point e, suggesting end-diastolic left ventricular diastolic dysfunction due to enhanced left atrial contraction. . Since the S point is not recognized, this is a finding that left ventricular systolic insufficiency or moderate or higher left ventricular hypertrophy is suspected. Unknown F point suggests early ventricular left ventricular diastolic dysfunction. A characteristic of this disease is that it exhibits a continuously rising waveform from point O to point A during diastole. Through the diastole, the effect of increased left ventricular pressure due to blood flowing back from the aorta to the left ventricle is considered.

Measurement Example 21.
FIG. 45 is an example of a 60 year old male with moderate mitral stenosis. The point E appears early and has a sharp shape because of the influence of the enhanced vibration of one sound. Since the left atrial contraction is not easily transmitted to the left ventricle due to mitral stenosis, a is a very low value. The points A and C are both less than 300 points, and the possibility of left ventricular end-diastolic load is low. In the diastole, blood from the left atrium to the left ventricle passes through the stenotic mitral valve, so that a rapid inflow wave (F wave) is not recognized and a wave that continuously rises up to the A wave is formed. It is characteristic of mitral stenosis.

Measurement Example 22.
FIG. 46 shows a 61-year-old woman with severe mitral regurgitation and heart failure. The points A and C are both less than 300 points. Point a is between one-fourth and one-half of point e, suggesting a left ventricular end-diastolic load due to left atrial contraction. The E wave is rounded and the E point is unclear. There is no S point. If the S point is not recognized, left ventricular contraction disorder or left ventricular contractility is maintained, but there is a high possibility that the left ventricular hypertrophy is moderate or higher. A sharp F wave with overshoot caused by a large volume of blood rapidly flowing from the left atrium into the left ventricle is a hallmark of severe mitral regurgitation. Therefore, the f point is remarkably high and exceeds two-thirds of the e point.

  Next, algorithms related to the example of the present invention will be described.

  First. Examine the presence or absence of S point in the apex rhythm diagram. The S point is a positive extreme value (indicating a zero point when the differential value changes from + to-), which is less than 50 msec immediately before the two sounds of the phonocardiogram in the apex rhythm diagram. The point S means the end of the systole and at the same time means the start of the diastole. The point S is an index of left ventricular diastolic disorder and an index of contraction disorder. If the S point is present, the possibility of severe left ventricular injury (contraction failure, diastolic failure) is low.

  If the S point is not present, a left ventricular diastolic disorder is suggested. In addition to left ventricular diastolic disorder, left ventricular contraction disorder is suggested. In addition, there are suspected cases of left ventricular hypertrophy that is moderate or higher and normal left ventricular contraction.

  Next, consider point O.

  In general, the O point is the lowest point of the apex rhythm diagram observed in the early diastole. The interval from the two sounds to the point O is one index representing the left ventricular dilatability. Shows the extensibility of left ventricular myocardium. If the interval from the two sounds to the O point is long, it means that the extensibility of the left ventricular myocardium is reduced. Interval between 2 sounds and O point: less than 150 msec is determined as normal, and interval between 2 sounds and O point: 200 msec is determined as abnormal when 150 msec or more, and the first negative extreme value that is 200 msec or more away from 2 sounds is O Do not treat as a point.

  Next, the F wave will be described.

  The F wave is a relatively steep ascending wave starting from point O on the apex rhythm diagram, and is formed by rapid blood inflow from the left atrium in the early diastole to the left ventricle. Point F is the apex of the F wave. The end of the F wave almost coincides with the three sounds in time. Point f is the positive peak value of the F wave in the first derivative waveform of the apex rhythm diagram.

  It is determined that the F wave is not recognized in the apex rhythm diagram waveform which moves slowly and does not show the bending point. In this case, it is determined that neither F point nor f point exists. When F wave is not recognized, it is determined as left ventricular diastolic disorder. When the F point is higher than the C point in height, it is determined as abnormal. When the F point is less than the C point, it is determined as normal. When the F point is less than 50 points, it is determined as abnormal. This finding suggests a left ventricular diastolic disorder, which means that the left ventricle is difficult to expand in the early diastole. It is determined that the F point is 50 points or more and less than 200 points is normal. It is determined that an F point of 200 points or more is abnormal.

  When the F point is 200 points or more, it indicates a left ventricular diastolic disorder, which means an increase in load in the initial stage of expansion. This finding that the F point is 200 points or more may be recognized in an example in which the left ventricular function is normal and the extensibility of the left ventricular myocardium is particularly good. It also shows the pathological state in the early stage of left ventricular dilation. There are two morbid states, one is a finding that suspects an absolute increased ventricular diastolic load. Diseases that increase blood flow through the mitral valve orifice (mitral regurgitation, ventricular septal defect, patent ductus arteriosus) or high cardiac output (hyperthyroidism, moderate or higher anemia, pregnancy Suspected of fever). The other may be suspicious of increased relative ventricular diastolic load. That is, the left ventricular myocardium is damaged and the load becomes excessive without increasing the blood flow through the mitral valve opening. The increase in the left ventricular residual blood volume at the end systole due to the left ventricular contraction disorder and the increase in the left ventricular filling pressure in the early diastole cause the left heart failure to produce a high F point. It usually presents with congestive heart failure with left ventricular enlargement and increased left ventricular filling pressure. Frequent examples include myocardial infarction patients and dilated cardiomyopathy patients.

  If there is an overshoot finding in the F wave, the left ventricular myocardial extensibility is normal (good compliance), or an increase in the left ventricular load at the beginning of dilation is suspected. If there is no overshoot, there is no left ventricular diastolic dysfunction, or diastolic dysfunction is implied, meaning that the extensibility of the left ventricular myocardium is reduced (poor compliance).

  Next, point f will be described.

  When the height of the point f is less than half the height of the point e, it is determined as normal. When the height of the point f is one-half or more of the height of the point e and less than two-thirds, it is determined that attention is required in the boundary area. An abnormality is determined when the height of the point f is 2/3 or more of the height of the point e. When the f point is relatively higher than the e point (when the f point is more than half of the e point), it indicates a load load in the early stage of left ventricular expansion. As with point F, the pathologic state in the early left ventricular dilation is also shown. There are two pathologic conditions, one is an absolute ventricular diastolic load increase. Diseases that increase blood flow through the mitral valve orifice (mitral regurgitation, ventricular septal defect, patent ductus arteriosus) or high cardiac output (hyperthyroidism, moderate or higher anemia, pregnancy Suspected of fever). The other may be a relative ventricular diastolic load increase. That is, the left ventricular myocardium is damaged and the load becomes excessive without increasing the blood flow through the mitral valve. Increased left ventricular residual blood volume at the end of systole due to left ventricular contraction and increased left ventricular filling pressure in the early diastole combined cause left heart failure. It usually presents with congestive heart failure with left ventricular enlargement and increased left ventricular filling pressure. Frequent examples include myocardial infarction patients and dilated cardiomyopathy patients.

  The F wave, the F point, and the f point are all indexes indicating a phenomenon of early left ventricular dilation.

  The more severe heart failure, the more prominent the F wave, F point, and f point (indicating high values), and the earlier the appearance time of the F wave, F point, and f point. However, as an exception, there may be cases where the left ventricular function is normal and the left ventricular myocardial extensibility is good.

  Next, point A will be described.

  FIG. 47 shows the A wave classification. The type of A wave is classified into the following four types. Type 1 is a case where the A wave is clear and the positive extreme value A point is clear, and the C point is also clear. Type 2 is a waveform that rises from the rise of the A wave to the C point. The A point and the C point are at substantially the same height, but in the first-order differential waveform, the portion corresponding to the C point has a negative extreme value (the differential value changes from − to +). Type 3 is a waveform in which the A wave continuously rises up to the point C, and does not have a negative extreme value (the derivative value changes from − to +) in the portion corresponding to the point C in the primary differential waveform. In this case, point A and point C are defined to be the same. Type 4 is determined when almost no positive wave is observed before point C, and no A wave is recognized. In this case, neither point A nor point a exists.

  When there is no A wave, that is, when there is almost no positive wave before point C, it is determined that there is no A wave, and neither A point nor a point exists. There may be normal cases where no load is applied at the end of the left ventricular diastole or pathological cases in which the left atrial contractile function is lost or reduced.

  When A wave is recognized, there is point A and point a also exists. As in Type 3, point A may be the same as point C (when the A wave continuously rises and reaches point C).

  When the height of point A is 300 points or more, it is determined as abnormal. If the height of the point A is 300 points or more, it indicates an increase in the load at the end of the left ventricular end diastole. Suspension of the left ventricular myocardium, ie, hypertension, left ventricular hypertrophy due to aortic stenosis or hypertrophic cardiomyopathy, fibrosis or degenerative myocardial infarction, secondary cardiomyopathy, etc. are suspected. It is also affected by an increase in load from the beginning of diastole, so it shows increased blood flow through the mitral valve opening (mitral regurgitation, ventricular septal defect, patent ductus arteriosus) and high cardiac output. Suspected condition (hyperthyroidism, moderate or higher anemia, pregnancy, fever). It is also suspected that the left ventricular myocardium, such as myocardial infarction or dilated cardiomyopathy, is damaged and the load is excessive without increasing the blood flow through the mitral valve opening.

  When the height of point A is less than 300 points, it is determined as normal.

  Next, point a will be described.

  It is clearly determined that the point a is more than half of the point e. A high point a may indicate an increase in left ventricular pressure due to the enhancement of left atrial contraction at the end diastole. Suspected hypertension with reduced extensibility of left ventricular myocardium, left ventricular hypertrophy due to aortic stenosis or hypertrophic cardiomyopathy, myocardial infarction causing fibrosis or degeneration, secondary cardiomyopathy, etc. When the point a is more than a quarter of the point e and less than a half, it is determined that attention is required in the boundary area. It is determined that point a is less than a quarter of point e as normal. When point a is lower than point f, it is possible that normal left ventricular function has particularly good left ventricular diastolic function, or conversely, severe heart failure (compensation failure).

Both A point, a point, and C point are indices indicating the dynamics of the left ventricular end diastole. Since A point, a point, and C point are related, it is considered that the pathological condition can be classified as follows when the mutual relation is examined for these three items. In the case of Type 1 and Type 2 shown in FIG. 47, when the A point is high, the C point is high, and the a point is high, an increase in left atrial contractility and an increase in left ventricular end diastolic pressure are suggested. When the A point is high, the C point is high, and the a point is low, an increase in the left ventricular end diastolic pressure is suggested without the presence of increased left atrial contractility. When the A point is high, the C point is normal, and the a point is high, increased left atrial contractility is suggested. When the A point is high, the C point is normal, and the a point is low, it is suggested that the left ventricular end-diastolic load is mild. When point A is low, point C is normal, and point a is low, it is suggested that there is no left ventricular end-diastolic load. When the A point is low, the C point is normal, and the a point is high, increased left atrial contractility is suggested.

  When point A and point C are the same as in type 3, when point C is high and point a is low, it is suggested that the left ventricular end-diastolic load is mild. When the C point is high and the a point is high, an increase in left atrial contractility and an increase in left ventricular end-diastolic pressure are suggested. When point C is low and point a is low, it is suggested that there is no left ventricular end-diastolic load. When the C point is low and the a point is high, increased left atrial contractility is suggested.

A wave height is defined by left atrial contraction force, mitral valve blood flow due to left atrial contraction and extensibility of left ventricular myocardium, suggesting the following conditions.
1: Left ventricular myocardial extensibility decreased due to left ventricular hypertrophy, ischemia, fibrosis.
2: Congestive heart failure.
3: High cardiac output.
4: Acute mitral regurgitation.

  As the cause, left ventricular hypertrophy, ischemia, and fibrosis as shown in 1 are most often caused by a decrease in left ventricular myocardial extensibility. Since resistance to left ventricular filling is large, left atrial contraction is enhanced and left ventricular end-diastolic pressure is thought to increase. In general, the cardiac output is maintained hemodynamically, the left ventricular contractility is not necessarily reduced, and the left ventricular filling pressure is often normal. Therefore, A wave height does not necessarily mean heart failure. Examples of left ventricular hypertrophy and normal left ventricular contractility include hypertrophic cardiomyopathy, hypertension, and aortic stenosis. Examples of left ventricular enlargement and reduced left ventricular contractility include myocardial infarction and dilated cardiomyopathy. In the congestive heart failure shown in 2, the left ventricular end-diastolic pressure rises and the left atrial contraction increases, and in this case, the left ventricular filling pressure also rises, and the F wave increases.

  In a state in which the left chamber pressure before the left atrial contraction has increased, the left chamber pressure rapidly increases immediately after the left atrial contraction, and the A wave and the point A appear early. In the high cardiac output state shown in FIG. 3, the A wave and the point A increase due to the fact that the left atrial contraction force is maintained and the blood flow rate passing through the mitral valve opening increases. In the acute mitral regurgitation shown in Fig. 4, the left atrial lesion is not present, the left atrial contractility is maintained, and the left ventricular end-diastolic pressure is increased due to a sudden left ventricular volume load. Increases in points A and a occur. The more severe the heart failure, the earlier the appearance phase of A wave and A point.

  Next, point C will be described.

  Point C is the start point of left ventricular contraction. Point C also reflects the end diastole condition. For point C, 300 points or more are determined to be abnormal. Left ventricular end-diastolic pressure may increase. The pathological conditions include left ventricular hypertrophy, ischemia, reduced extensibility of left ventricular myocardium due to fibrosis, congestive heart failure, and high cardiac output. High value in acute mitral regurgitation.

  Next, the points E and P will be described.

  If the point C to point E is less than 125 msec, the possibility of left ventricular contraction disorder is considered to be low. Although there is no left ventricular contraction disorder or left ventricular contraction disorder from 125 to 150 msec from point C to point E, there is a possibility of left ventricular hypertrophy of moderate or higher. When the point E does not exist and the point P exists, although there is no left ventricular contraction disorder or left ventricular contraction disorder, the possibility of moderate or greater left ventricular hypertrophy is great, and it is determined to be abnormal.

  In the biological reaction recording device according to the present invention, the basic data of the apex rhythm diagram is measured and taken into the device, and then the health condition of the subject is determined and recorded using the items related to each feature point described above. , Can make the necessary display.

As described above, the primary differential waveform of the apex rhythm diagram, that is, the primary differential waveform of the time-beat waveform, can be used for feature extraction related to the pulsation of the living body to be measured. Can be used for extracting feature points of the first derivative waveform of the apex rhythm diagram. In the utilization of the heart machine diagram for diagnosis, not only the waveform of the apex heartbeat diagram as data synchronized with the electrocardiogram or electrocardiogram, but also the use of the first and second derivatives, as well as the amplitude and amplitude distribution of the beat The use of information on intensity and intensity distribution is extremely important for accurate diagnosis.

  Regarding the grasp of the heart movement, it can be mentioned that the pulsation chart and the amplitude of the pulsation and the distribution of the amplitude can be known, but in addition to this, for example, whether the heart is moving vigorously or moving strongly It is possible to know the intensity and intensity distribution. As is well known to doctors who perform palpation, the heart moves in a complex manner, and the present invention provides the strength and intensity distribution of pulsations that can be felt by palpation as the strength of the heart and the strength of movement. Being able to be detected by a pressure sensor is important information for accurate diagnosis.

  The said Example can be utilized variously as needed, and can exhibit the effect which was not expectable conventionally.

  For example, after measuring the cardiac diagram, the results can be immediately explained to the patient, or the cardiac diagram can be shown to the patient and explained. Furthermore, the apparatus of the present invention includes, as one of reference data, past data of a measured living body, statistical data useful for diagnosis of the measured living body, and the like. It is possible to grasp the change of the above, or to explain to the living body to be measured for effective health management.

  An electrode for electrocardiogram measurement may be incorporated into the pressure sensor, and a microphone for electrocardiogram measurement may be incorporated into the pressure sensor. By configuring in this way, it is possible not only to enable high accuracy, simplification, miniaturization, price reduction, etc. of the recording apparatus, but also to measure by attaching many sensors to the measurement subject. Can greatly reduce the mental burden caused by.

  By forming the pressure sensor in a three-dimensional configuration, pressure and heart sounds can be detected, and the S / N ratio of measurement data can be increased.

  A transmitter or a transmitter / receiver is incorporated in the pressure sensor having various configurations as described above and attached to the living body to be measured, or a pressure sensor and a small and light transmitter or transmitter / receiver are attached to the living body to be measured. The device of the present invention is configured by transmitting or transmitting / receiving data measured by a sensor to an external device carried by the measurement living body or an external device away from the measurement target living body, and is useful for health management by the measurement living body itself. Or, a medical professional can perform diagnosis and health management of a living body to be measured.

  In the above example, the apex pulsation diagram has been described as an example of the pulsation diagram, but as described above, the present invention is not limited to the apex pulsation diagram, and the same applies to the various pulsations. It has a great effect.

  In the measurement of the electrocardiogram, even if the electrocardiogram and electrocardiogram sensors are provided in the apparatus of the present invention, the electrocardiogram and electrocardiogram data are measured separately from the apparatus of the present invention and input to the apparatus of the present invention. Even in this case, it is important to synchronize the pulsatogram with at least one of the electrocardiogram and the electrocardiogram. In this way, diagnosis can be performed with high reliability.

  As explained above, the chest and abdominal organisms that had to be recorded by a minimum of two doctors or doctors and technicians in a conventional large-scale measurement facility with a patient entering a special measurement room such as a soundproof room. According to the present invention, a response record can be measured in an outpatient office or hospital room of a hospital, and can also be recorded by a single doctor, and the data is recorded in a computer memory or the like. It can be played back as a moving picture on the spot from the data recorded in the. In other words, the present invention has a great effect as a medical treatment that can be fed back to the patient on the spot, the satisfaction of the patient is increased, and a patient in a state where a special measurement room such as a soundproof room cannot be connected. Examinations are also possible, and the quality of examination skills, such as visual inspection, palpation, and auscultation, is improved, and it is possible to make an accurate diagnosis of cardiovascular diseases.

  It is also extremely effective in lifelong education for doctors and clinical medical education for medical students and residents.

  Furthermore, the present invention enables wide application of medical expertise such as normal health management and remote health management.

  The embodiment of the electronic component according to the present invention has been described with reference to the embodiments. However, the present invention is not limited to the embodiments, and many variations using the technical idea of the present invention are described. Is possible.

  As described above, according to the present invention, a pulsation diagram relating to the chest and abdomen, which is extremely important in clinical practice of the circulatory system but is actually difficult and has not been accurately measured and recorded, can be obtained with considerably high accuracy. It can be measured and recorded, and can be fed back to medical care on the spot or used as past data, for example.

  The present invention significantly improves the medical care level of the circulatory system, enhances the cooperation effect with other medical fields, contributes greatly to the development of medicine, greatly contributes to the saving of medical expenses, etc. It has a great economic effect and is widely used in the medical field and medical education field.

It is a figure explaining the biological reaction recording device as an example of an embodiment of the invention. It is a block diagram explaining the biological reaction recording device which can also perform remote management as an embodiment of the present invention as an embodiment of the present invention. It is a block diagram explaining the example of the measurement data process in the biological reaction recording device as an embodiment of this invention. It is a figure explaining the pressure sensor as an example of an embodiment of the invention. It is a figure explaining the pressure sensor as an example of an embodiment of the invention. It is the example of the heart figure measured with the biological reaction recording device as an embodiment of the present invention. It is the example of the heart figure measured with the biological reaction recording device as an embodiment of the present invention. It is the example of the heart figure measured with the biological reaction recording device as an embodiment of the present invention. It is the example of the heart figure measured with the biological reaction recording device as an embodiment of the present invention. It is a figure explaining the example of the time change of the cardiac figure measured with the biological reaction recording device as an example of embodiment of this invention. It is a figure explaining the example of the time change of the cardiac figure measured with the biological reaction recording device as an example of embodiment of this invention. It is a figure explaining the example of the time change of the cardiac figure measured with the biological reaction recording device as an example of embodiment of this invention. It is a figure explaining the example of the time change of the cardiac figure measured with the biological reaction recording device as an example of embodiment of this invention. It is a figure explaining the example of the time change of the cardiac figure measured with the biological reaction recording device as an example of embodiment of this invention. It is a figure explaining the example of the time change of the cardiac figure measured with the biological reaction recording device as an example of embodiment of this invention. It is a figure explaining the example of the time change of the cardiac figure measured with the biological reaction recording device as an example of embodiment of this invention. It is a figure explaining the pressure detection position of the pressure sensor in the biological reaction recording device as an embodiment of the present invention. It is a figure explaining the example of the amplitude distribution of the pulsation measured with the biological reaction recording device as an example of an embodiment of the invention, and is the figure shown as a sectional view in the predetermined position of the figure of three-dimensional display. It is a figure explaining the example of the amplitude distribution of the pulsation measured with the biological reaction recording device as an example of an embodiment of the invention, and is the figure shown as a sectional view in the predetermined position of the figure of three-dimensional display. It is a figure explaining the apex pulsation figure measuring method using the apex pulsation figure measuring device as an example of the biological reaction recording device of this invention, and is a block diagram explaining the flow of a measurement. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is a figure explaining the division of the systole and the diastole of a cardiac cycle. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is an example of the apex rhythm diagram measured using the apex rhythm diagram measuring device of the present invention. It is a figure explaining A wave. It is a photograph of a conventional heart mechanism diagram recording apparatus main body. It is a photograph of the example of various conventional transducers. It is a perspective view of the conventional biological sound detection apparatus. It is sectional drawing of the biological sound detection apparatus of FIG. It is a perspective view of the transducer for the pulsation figure measurement of the conventional heartbeat diagram recording device. It is a perspective view of the transducer for heart sound figure measurement of the conventional heart-cardiogram recording apparatus. It is a photograph of a living body to be measured with a conventional apparatus. It is a heartbeat diagram obtained as a result of measurement by a conventional heartbeat diagram recording apparatus.

40: Microphone 101, 502, 512, 522, 532, 552, 556, 560, 564, 568, 572, 576: Apical rhythm diagram 102, 103, 104, 553, 557, 561, 565, 569, 573, 577 : Electrocardiogram 105, 554, 558, 562, 566, 570, 574, 578: Electrocardiogram 110: Transducer for pulsatogram measurement 111: Pressure transmission part 112, 122: Case outer peripheral frame 113, 123: Case side surface 114, 124: Lead wire 120: Transducer for heart sound diagram measurement 121: Heart sound measurement unit 200: Biological reaction recording device 201, 201a, 201b, 301: Pressure sensor 202, 305a: Heart sound sensor 203: Electrocardiogram sensor 211, 212, 213 , 231, 241: wiring 220, 3 20: Control / measurement data processing unit 230, 330: Storage unit 240, 340: Display unit 241a to 241c, 242a to 242c, 243a to 243c, 244a to 244d, 251a to 251c, 252a to 252c, 253a to 253c: Pressure sensor 245: Inner wall of the outer peripheral portion of the pressure sensor 246, 255: Outer wall of the outer peripheral portion of the pressure sensor 247: Space portion 248, 258: Substrate 271 to 287: Reference numeral 300 for explaining processing steps, processing contents, functions, etc. Biological reaction recording system 305b: Sensors 311, 315a, 315b, 331, 341, 351: Contact means 350: Remote management unit 500, 510, 520, 530: Heartbeat diagram 501, 511, 521, 531, 551, 555, 559, 563, 567, 571, 575: cardiac apex Primary differential curves 503,513,523,533: electrocardiogram 504,514,524,534: electrocardiogram 5011,5013,5014,5111,5113,5114,5211,5213,5214,5311,5313,5314: apex Peak of first-order differential curve of pulsation diagram 5031, 5131, 5231, 5331: 1 sound 5032, 5132, 5232, 5332: 2 sounds 5333: State where 3 sounds and 4 sounds are superimposed 5034, 5134: 4 sounds 5041, 5141 5241, 5341: QRS wave 5511, 5551, 5591, 5631, 5671: Extreme value of differential waveform in isovolumetric systole 5514, 5554, 5594, 5634, 5684: Extreme value of A wave A1-A5: Each apex pulse A wave (left atrial contraction wave)
d1 to d9, d31 to d3, d91: Points for explaining examples of features of the differential waveform of the apex rhythm diagram P1 to P9: Symbols indicating pressure detection positions

Claims (6)

A biological reaction recording method for use in a configured biological reaction recording device,
The biological response recording apparatus is configured to include a heartbeat or ascending aorta beat or pulmonary artery (pulmonary artery trunk and central pulmonary artery) as at least one kind of pulsation of the apex, right ventricle and left atrium of a living body. A novel biological reaction capable of detecting a measurement value capable of generating at least one pulsation chart of pulsation or abdominal aorta pulsation or liver pulsation (including at least one) as a measurement result of wave reflection In the recording device, biological reaction information (hereinafter referred to as biological information) is obtained based on the reflected wave detection sensor that measures the movement of at least one pulsation detection site using the reflected wave of the wave and the measured data. Biological information or data processing means detected using data processing means such as an arithmetic processing unit that can be detected, at least a main part of measured data, and data processing means Data processed using or data such as information in the middle of processing (hereinafter referred to as biometric information detected using the data processing means, data processed using the data processing means or data in the middle of processing detected data, etc. And the reflection detection sensor includes a plurality of detection sensors capable of distinguishing and measuring measurement data at a plurality of measurement sites. The reflection detection sensor can measure the reflection information of the living body with respect to one pulsation to be measured, and the storage means stores at least one of the measurement data at the plurality of locations and at least one of the detection data. Is a biological reaction recording device characterized in that
The biological reaction recording method includes a step of arranging a reflected wave detection sensor capable of detecting a measurement value of a pulsation capable of creating at least one pulsation diagram as a measurement result of reflection of the wave;
Determining the health condition of the measured living body detected based on at least one of the measurement data measured by the reflected wave detection sensor and the detection data;
A process of outputting the health status of the measured living body
A biological reaction recording method comprising: A biological reaction recording method for use in a configured biological reaction recording device,
The biological reaction recording apparatus is a novel biological reaction recording apparatus capable of detecting a measurement value capable of creating a cardiac apex rhythm diagram of a living body as a measurement result of pressure change and / or wave reflection, and at least one A pressure sensor that can measure the movement of the pulsation detection site as a pressure change and / or a reflection detection sensor that measures the reflection using wave reflection, an amplification means such as a measured signal, and a measured data Biological information or data processing detected using data processing means such as an arithmetic processing unit capable of detecting biological reaction information (hereinafter referred to as biological information) based on the data processing means and at least the main part of the measured data Storage means that can store at least one of data such as information processed using the means or information being processed Data such as biological information detected using the data processing means, information processed using the data processing means or information in the middle of processing is referred to as detection data), and the pressure sensor and / or reflection detection. The sensor is composed of a plurality of detection sensors capable of distinguishing and measuring the measurement data at a plurality of measurement sites, and the pressure sensor and / or the reflection detection sensor is configured to detect the pressure of the living body and the one pulsation to be measured. It is possible to measure reflection information respectively, and / or the storage means can store at least one of the measurement data of the plurality of locations and at least one of the detection data, the biological reaction recording device,
The biological reaction recording method includes:
Arranging a reflected wave detection sensor capable of detecting a measurement value of a pulsation capable of creating at least one pulsation diagram as a measurement result of reflection of the wave;
Determining the health condition of the measured living body detected based on at least one of the measurement data measured by the reflected wave detection sensor and the detection data;
A process of outputting the health status of the measured living body
A biological reaction recording method comprising: The biological reaction recording method according to claim 2,
Characteristic points related to apex rhythm are identified as 2 sounds (aortic valve closing sound) from the phonogram during the 1 pulsation period, and before the 2nd sound in the time axis (horizontal axis) direction in the apex rhythm diagram The positive extreme value closest to two sounds that are less than 50 msec apart from the two sounds is the S point, and when there is a negative extreme value near the apex of the QRS wave on the electrocardiogram, the negative extreme point is the C point If there is no negative extreme value near the apex of the QRS wave of the electrocardiogram, a perpendicular line is taken from the R of the electrocardiogram, and the point where the perpendicular intersects the apex rhythm waveform is the C point. If the A wave has a positive extreme value as point A, and the A wave does not have a positive extreme value and rises continuously and reaches point C, which will be described later, C point is regarded as point A, C point The positive extreme value less than 150 msec from E point is E point, and when neither E point nor S point exists, 150m from C point The positive extreme value that is delayed by ec and more than 50 msec before the second sound of the phonogram is P point, and the first negative extreme value of the apex rhythm diagram is O point after 50 msec or more from the second sound, The first positive extreme value less than 150 msec from O point is the F point, the positive wave due to left atrial contraction is the A wave, the left ventricular systolic wave is the E wave, and the rapid inflow wave is the F wave And the positive peak values of the A wave, E wave, and F wave in the first derivative waveform of the apex rhythm are a point, e point, and f point, respectively, and the amplitude axis (vertical axis) of the apex rhythm waveform is the minimum value. Is normalized to 0 points and the maximum value is normalized to 1000 points.
The biological reaction recording method includes:
And having the step of determining the presence or absence of at least one of the feature points, and
Determination means for determining whether the height of point A is less than 300 points or 300 points or more;
Determination means for determining whether the height of point C is less than 300 points or 300 points or more;
determining means for determining whether the height of the point a is less than a quarter of the point e, or more than a quarter, less than a half, or more than a half; ,
Determination means for determining whether the height of the F point is less than 50 points, 50 points or more, less than 200 points, or 200 points or more;
determining means for determining whether the height of the point f is less than half of the point e, or more than half, and less than two thirds, or more than two thirds; ,
When determining means for determining whether or not the F wave has an overshoot,
The biological reaction recording method further includes:
A biological reaction recording method comprising: determining at least one of the determination means as a step of determining a health state of a living body to be measured. The biological reaction recording method according to any one of claims 1 to 3, wherein in the step of outputting the determined health state of the measured living body, the determination information is set to health, caution 1, caution 2, danger, etc. A biological reaction recording method characterized by using a display means or an output means for suggesting the health level of the measured living body. 5. The biological reaction recording method according to claim 1, wherein a part of the biological reaction recording apparatus in which the pressure sensor and / or reflection detection sensor is arranged is a first part of the biological reaction recording apparatus. And the portion where the pressure sensor and / or the reflection detection sensor is not disposed is referred to as a second portion of the biological reaction recording device, and the biological reaction recording method covers the first portion of the biological reaction recording device. A biological reaction recording method, comprising: a step of disposing the second portion on a portion to be measured of the living body to be measured and disposing the second portion on the other portion. The biological reaction recording device according to any one of claims 1 to 5, wherein the first part of the biological reaction recording device is disposed at a measurement position of the biological subject to be measured, and the second part of the biological reaction recording device is disposed. The first part and the second part of the biological reaction recording apparatus are arranged to transmit information by wireless communication and / or wired communication, and are arranged at positions different from the arrangement position of the first part. Biological reaction recording device.