CN105595983B - A kind of blood pressure measuring device and the method for improving blood pressure measurement accuracy - Google Patents
A kind of blood pressure measuring device and the method for improving blood pressure measurement accuracy Download PDFInfo
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Abstract
The method of blood pressure measurement accuracy is effectively improved the present invention provides a kind of blood pressure measuring device, based on the measuring device and judges the method that arteries closes state and open state moment.The present invention by continuous acquisition to Korotkoff's Sound vibration signal, to the detection of heart cycle waveform, to the fixed extraction with pressure signal, realize and accurate obtain pressure value.The present invention efficiently solves existing sphygmomanometer and is easily disturbed, detects the problems such as limited reliability, it can accurately and effectively identify the functional relation of human body Korotkoff's Sound vibration signal and cardiac cycle, so as to accurately judge the accurate value of human blood-pressure, the present invention can also gather multinomial physiological parameter simultaneously, provide data for relevant medical diagnosis and scientific research and support.The measuring device and method of the present invention is suitable for conventional blood pressure measurement, the multiple fields such as clinical diagnosis and family health care with the relevant diseases such as heart, blood vessel, blood.
Description
Technical field
The present invention relates to the method and devices for obtaining human body physiological parameter, and in particular to a kind of blood pressure measuring device, especially
It is related to a kind of measuring device based on human body Korotkoff's Sound vibration signal continuous acquisition and record and to effectively improve blood pressure measurement accurate
The method of degree.The invention further relates to a kind of methods for judging arteries and closing state and open state moment.
Background technology
Since Russia doctor Nicolai Korotkoff in 1905 with the appearing and subsiding of Korotkoff's Sound come differentiate systolic pressure and
Since diastolic pressure, by century more than one, the blood for truly meeting goldstandard electronization there are no one in the world and differentiating
Measuring instrument is pressed, the human auscultation that Nicolai Korotkoff are proposed then is still currently generally acknowledged non-invasive blood pressure measurement
Goldstandard.But also there is shortcoming, exactly different people may measure different as a result, difference is larger sometimes, and result is by artificial
It is affected, such as the hearing of different people, resolving power and proficiency are different, to respectively having not (i.e. on the time) in the discrimination of Korotkoff's Sound
Together；The speed of artificial deflation speed (international standard deflation speed is 3-5mmHg per second) also can generate shadow to the accuracy of measurement
It rings；Some blood pressures virtual height person, cardiac arrhythmia person, shock patient, Korotkoff's Sound the Clinical signs stethoscopy such as do not disappear can not be surveyed accurately
Amount.In general, in artificial measuring blood pressure, different doctors is to have difference to the measurement result of same tested person's different time
's.Normal variations are usually considered inside 5~15mmHg.
At present, the method for noninvasive blood pressure measurement mainly has the stethoscopy based on Korotkoff's Sound, oscillographic method, Palpation, ultrasound
Method etc..Most of sphygmomanometer product, is all based on oscillographic method on existing market.Although this method measures stability
It is good, still, since medical field is employed for a long time based on gold of the mercury stethoscopy of Korotkoff's Sound principle as blood pressure measurement
Standard, and oscillographic method is by recording pulse wave and pressure wave, judges mean pressure using maximum amplitude method, is united further according to crowd
Meter obtains range coefficient to estimate systolic pressure and diastolic pressure, it is clear that the pressure value of this method measurement be it is not accurate enough, in addition
Due to the disunity of testing standard, the algorithm of each producer is also different, and pulse wave is directly by vascular wall hardness, heart
The influence of the common factors such as valve situation, the individual difference of measured will cause measurement result, and there are constant errors, it is clear that Bu Nengman
The personalized difference of the measured object of foot.In addition, the fatal defects of oscillographic method electronic sphygmomanometer be measurement result accuracy it is poor,
It is with a low credibility, usually it is only capable of meeting error less than 10mm mercury column, and this error will cause substantial amounts of mistaken diagnosis and fail to pinpoint a disease in diagnosis.Therefore,
All the time, all constantly queried using the measurement accuracy of oscillographic method as the electronic sphygmomanometer of judgement foundation.In America and Europe
Countries, the measurement of law bans hospital using such sphygmomanometer are recorded a demerit as the foundation to diagnose the illness.But due to mercury
In the extension process of stethoscopy, on the one hand need using mercury, and this can be next to environment and user's health care belt dangerous；The opposing party
Face, auscultation process needs could be carried out effectively under the guidance of professional medical practitioner, and otherwise ordinary user can not be exactly
It is operated.Therefore, though stethoscopy is good, but the popularization of large area can not be obtained beyond hospital, and multipurpose household electronics
The blood pressure measuring of oscillographic method is taken blood pressure.
The electronic sphygmomanometer for the sensors such as electricity consumption auscultation occur and obtaining Korotkoff's Sound domestic in recent years.Compared with goldstandard,
Its accuracy greatly improves.In environment relatively quietly, most of result can be basically identical with stethoscopy.But due to
The direct utilization of Korotkoff's Sound acoustic information is still fallen in mentality of designing, lacks and solution is found from the physical essence that Korotkoff's Sound occurs
Certainly scheme, therefore there are still being easily disturbed, the problems such as detection limited reliability affect its use scope.
In conclusion the sounding physical essence based on Korotkoff's Sound, records the continuous shaking physiological signal of Korotkoff's Sound, and build
The correspondence and analysis model of the various diseases such as Korotkoff's Sound signal and heart, blood vessel, blood will be effectively and accurately blood pressure
Multiple medical domains such as measurement, clinical diagnosis, family health care provide technical support.
The content of the invention
The present invention provides a kind of methods and blood pressure measurement that blood pressure measurement exact value is improved based on Korotkoff's Sound vibration signal
Device, to overcome defect present in known technology.
According to an aspect of the invention, there is provided a kind of blood pressure measuring device, it being capable of continuous acquisition and record Korotkoff's Sound
Physiological vibrations signal and other physiological signal parameters, including multi-parameter physiology signal acquisition module (10), signal processing mould
Block (20), central processing module (30), LCD MODULE (40), control module (50), full waveform recording show analysis module
(60), memory module (70), network module (80)；
The multi-parameter physiology signal acquisition module (10) includes outer layer fixation band (11), internal layer fixes band (12), fixed
Band pressure sensor (13), korotkoff sound sensor (14), Korotkoff's Sound delay acquisition module (15), charge/discharge gas control unit (16),
Temperature Humidity Sensor (17), pulse wave sensor (18) and moving state identification module (19)；
The display information of the LCD MODULE (40) include systolic pressure, diastolic pressure, mean pressure, pulse frequency, test No.,
Mercury, temperature and humidity value, electricity are simulated, which receives central processing module (30) and calculate the continuous of analysis
Korotkoff's Sound vibration signal, and with the graphical display of mercury；
The control module (50) includes multiple key control units, including starting, stopping, counting, backlight, pattern, sets
Put, number, add and subtract button, control instruction can be sent to by button by central processing module (30), complete data typing,
Acquisition, analysis are arranged and exported；
The full waveform recording display analysis module (60) is for fixed terminal (61) and/or mobile terminal (62) and/or just
Take formula terminal (63)；
The memory module (70) receives the Korotkoff's Sound digital signal of central processing module (30) and control module (50) record
All information parameter data entered, memory module (70) can automatic or manual mode copy data to full waveform recording and show point
Analyse module (60)；
The network module (80) receives the Korotkoff's Sound digital signal of central processing module (30) and control module (50) record
Data can be reached high in the clouds and carry out data preservation by all information parameter data entered, network module (80).
Further, blood pressure measuring device of the invention further includes sensor stabilization structure (120), is fixed on internal layer and consolidates
Determine the inside of band；Sensor stabilization structure (120) includes carbon fiber diaphragm (121), fixed sleeve part (123), fixed rubber ring card
Part (124) and square foam stabilizing member (125)；
Sensor is fixed in rubber ring by fixed sleeve part (123) and fixed rubber ring fastener (124), and square foam is stablized
Part (125) by carbon fiber diaphragm (121) and fixed rubber ring fastener (124) be fixed therein between circular trough in.
Further, the pressure characteristic to human contact face for being used to identify fixed band with pressure sensor (13) is fixed,
Pressure signal is reached into central processing module (50) through signal processing module (20), discharge charge is controlled by central processing module (50)
Gas control unit (16) carries out the inflation/deflation process that outer layer fixes band (11).
Further, the Korotkoff's Sound of generated arterial vascular system shakes under korotkoff sound sensor detection blood kinetic energy impact
Signal is reached Korotkoff's Sound delay acquisition module (15) by dynamic signal, and the module (15) is by default algorithm and formula by Ke Shi
The physiological signal of sound sensor (14) acquisition reaches after being handled and gives signal processing module (20).
Further, the humiture information of Temperature Humidity Sensor (17) acquisition fixed band and skin contact surface, pulse wave pass
The vibration signal of sensor (18) and korotkoff sound sensor (14) synchronous recording human pulse ripple.
Further, the raw digital signal of reception is reached Full wave shape by central processing module (30) through USB transmission mode
Record shows analysis module (60) or is stored automatically in memory module (70) or transfers the raw digital signal of reception automatically
Network module (80) is given, and reaches high in the clouds through network module (80) and preserves.
According to another aspect of the present invention, a kind of method for improving blood pressure measurement accuracy is provided, including following step
Suddenly：
The first step detects the Korotkoff's Sound vibration signal of generated arterial vascular system under blood kinetic energy impact；
Second step determines the Korotkoff's Sound vibration signal in the position of corresponding cardiac cycle, to differentiate that the Korotkoff's Sound vibrates
The authenticity of signal；
3rd step obtains Korotkoff's Sound vibration and instantaneous fixed band pressure value occurs.
In second step, the authenticity of the signal refers to effectively to judge that Korotkoff's Sound signal falls on a complete cardiac cycle
It is interior, just it is considered as authenticity.
In 3rd step, obtaining instantaneous method of the fixation band with pressure value of Korotkoff's Sound vibration generation includes：
Korotkoff's Sound vibration signal is first appeared during complete cardiac cycle, and it is a aroused in interest in subsequent n (n >=2)
In the case that Korotkoff's Sound vibration signal occurs again in cycle, Korotkoff's Sound vibration signal moment corresponding fixed band will be first appeared
Pressure value is determined as systolic pressure；
With the gradual decrease of Korotkoff's Sound vibration signal, when Korotkoff's Sound vibration signal within a complete cardiac cycle for the first time
During disappearance, and within subsequent n (n >=2) a cardiac cycle Korotkoff's Sound vibration signal also no longer occur in the case of, by Korotkoff's Sound
The vibration signal moment corresponding fixed band pressure value that disappears for the first time is determined as diastolic pressure.
According to another aspect of the present invention, a kind of side for judging arteries and closing state and open state moment is additionally provided
Method comprises the following steps：
The first step detects the Korotkoff's Sound vibration signal of generated arterial vascular system under blood kinetic energy impact；
Second step, by fixed with a series of korotkoff's sound delay time T obtained in complete deflation course and corresponding
Fixed band values of pressure p, formation function TK (P) with reference to the signal of pulse wave sensor in deflation course, determine that the Korotkoff's Sound vibrates
Signal is to determine korotkoff's sound delay time in the position of corresponding cardiac cycle, it is thus determined that the Korotkoff's Sound vibration signal is right
The position for the cardiac cycle answered, to differentiate the authenticity of the Korotkoff's Sound vibration signal；
3rd step judges that arteries opens the method for state to first appear Korotkoff's Sound during complete cardiac cycle
Vibration signal, and in the case that Korotkoff's Sound vibration signal occurs again within subsequent n (n >=2) a cardiac cycle, will go out for the first time
At the time of the existing Korotkoff's Sound vibration signal moment is determined as open state；Judge that arteries closes the method for state to be vibrated with Korotkoff's Sound
The gradual decrease of signal, when Korotkoff's Sound vibration signal disappears for the first time within a complete cardiac cycle, and in subsequent n (n
>=2) in the case that Korotkoff's Sound vibration signal also no longer occurs in a cardiac cycle, Korotkoff's Sound vibration signal is disappeared the moment for the first time
At the time of being determined as closing state.
The present invention by continuous acquisition to Korotkoff's Sound vibration signal, to the detection of heart cycle waveform, with pressure to fixation
The extraction of force signal realizes accurate acquisition pressure value.Compared to original " goldstandard ", the physics generated closer to Korotkoff's Sound
Essence, therefore result is more accurate.The present invention can accurately and effectively identify human body Korotkoff's Sound vibration signal and the letter of cardiac cycle
Number relation, so as to accurately judge the accurate value of human blood-pressure, while the present invention can gather multinomial physiological parameter simultaneously, be relevant
Medical diagnosis and scientific research provide data and support.The measuring device and method of the present invention is suitable for conventional blood pressure measurement, with heart, blood
The multiple fields such as the clinical diagnosis and family health care of the relevant diseases such as pipe, blood.
Description of the drawings
Fig. 1 is the measuring device structure diagram of the present invention.
Fig. 2 is the multi-parameter physiology signal acquisition module structure diagram of the present invention.
Fig. 3 is sensor of the invention rock-steady structure schematic diagram.
The full waveform recording that Fig. 4 is the present invention shows analysis module schematic diagram.
Fig. 5 is the LCD MODULE schematic diagram of the simulation mercury of the present invention.
Fig. 6 is the full structure diagram of blood pressure measuring device of the present invention.
Fig. 7 is several different fixed forms that the fixation band of the present invention is previously mentioned.
Fig. 8 is with pressure for the korotkoff's sound delay time of the method for the acquisition Korotkoff's Sound signal described in the embodiment of the present invention and fixation
Relation schematic diagram between power.
Fig. 9 is Korotkoff's Sound during the cuff pressure of the method for the acquisition Korotkoff's Sound signal described in the embodiment of the present invention declines
The schematic diagram of time-delay characteristics of the vibration signal on cardiac cycle.
Specific embodiment
The measuring device of the present invention includes multi-parameter physiology signal acquisition module (10), signal processing module (20), center
Processing module (30), the LCD MODULE (40) for simulating mercury, control module (50), full waveform recording show analysis module
(60), memory module (70), network module (80).
The multi-parameter physiology signal acquisition module (10) includes outer layer fixation band (11), internal layer fixes band (12), fixed
Band pressure sensor (13), korotkoff sound sensor/piezoelectric transducer (14), Korotkoff's Sound delay acquisition module (15), discharge charge gas control
Unit (16) processed, Temperature Humidity Sensor (17), pulse wave sensor (18) and moving state identification module (19) multiple structures.It should
The structure design that outer layer fixes band (11) makes it that can not only be fixed on progress signal acquisition at upper brachial artery, can also fix
At the arteries such as forearm, thigh, shank (as shown in Figure 7).It is flexible tubular structure that internal layer, which fixes band (12), and material can be with
The compositions such as rubber, elastic cloth, spandex gluing, can effectively tight limbs end ensure it is more in sensor stabilization structure (120)
A sensor is close at the artery of limbs, and ensures charge/discharge gas control unit (16) during inflatable and deflatable, and outer layer is solid
The relative movement of sensor will not be caused by determining the movement of band 11, ensure the accuracy of test result.Outer layer fixes one end of band 11
It is fixedly connected on the outside that internal layer fixes band 12.Meanwhile internal layer is fixed the air hole promotion for having marshalling with (12) and was tested
The comfort of limbs in journey.Sensor stabilization structure (120) is fixed on the inside (contact limbs end is inside) that internal layer fixes band,
It can guarantee that fixed band pressure sensor (13) and korotkoff sound sensor (14) can effectively contact human body artery and go out to gather physiological signal.
Moving state identification module (19) includes multi-shaft acceleration transducer and/or strain transducer, is installed on sensor stabilization structure
In 120, which identifies the state of the motion and standstill of human body by multi-shaft acceleration transducer, is known by strain transducer
The operating state of other limbs, and without physiological signal collection when ensureing human body dynamic.Fixed band pressure sensor (13) is used for
The pressure characteristic to human contact face of the fixed band of identification, central processing mould is reached by pressure signal through signal processing module (20)
Block (50) carries out outer layer by central processing module (50) control charge/discharge gas control unit (16) and fixes the inflation/deflation mistake with (11)
Journey.The Korotkoff's Sound of generated arterial vascular system under korotkoff sound sensor/piezoelectric transducer (14) detection blood kinetic energy impact
Signal is reached Korotkoff's Sound delay acquisition module (15) by vibration signal, and the module (15) is by default algorithm and formula by Ke
The physiological signal of family name's sound sensor/piezoelectric transducer (14) acquisition reaches after being handled and gives signal processing module (20).It is warm and humid
The humiture information that sensor (17) gathers fixed band and skin contact surface is spent, pulse wave sensor (18) is sensed with Korotkoff's Sound
The vibration signal of device/piezoelectric transducer (14) synchronous recording human pulse ripple.
The sensor stabilization structure (120) includes carbon fiber diaphragm (121), sensor group (122), fixed sleeve part
(123), fixed rubber ring fastener (124) and square foam stabilizing member (125), carbon fiber diaphragm (121) can stablize conducting arteries
The impact force signal of middle blood, fixed sleeve part (123) and fixed rubber ring fastener (124) are consolidated what sensor group (122) was stablized
It is scheduled in rubber ring, avoids sliding, square foam stabilizing member (125) is by carbon fiber diaphragm (121) and fixes rubber ring fastener
(124) in the circular trough between being fixed therein, after internal layer, which fixes band (12), tightens artery, square foam stabilizing member (125) energy
Ensure that local change in displacement effectively with artery is close to and is not occurred to carbon fiber diaphragm (121), so as to effectively collect multinomial life
Manage signal.Square foam stabilizing member (125) is the rectangle foam structure of 60mm wide 40mm thickness 5mm one long, in inside configuration
There are one the circular trough of diameter 30mm, for accommodating and clamping sensor group (122), and being led in its one end there are one 2mm wide
Line groove opening is pierced by for accommodating conducting wire, is the support base of cavity structure, pedestal two inside fixed rubber ring fastener (124)
End have upward flange, formed higher than the cavity structure " L-type " buckle structure, can with clamping sensor group (122), Gu
Determine external member (123) and sensor group (122) transmission line is fixed on base bottom, and along the conducting wire of fixed rubber ring fastener (124)
Groove is pierced by.The sensor group 122 includes korotkoff sound sensor, Temperature Humidity Sensor, pulse wave sensor, multiaxis acceleration
Sensor and/or strain transducer.Fixed sleeve part (123) can be buckle or other wire bundle fixing structures.
The signal processing module (20) receives all kinds of physiology numbers that multi-parameter physiology signal acquisition module (10) is gathered
According to and signal, be sent to the center after the filtering of the signal processing module (20) converts analog signals into digital signal
Processing module (30).The realizations such as dsp chip may be employed in signal processing module (20).Sensor group (122) is Korotkoff's Sound sensing
Device 14.
The central processing module (30) receives the instruction that the control button in control module (50) is assigned, and can start
Charge/discharge gas control unit (16) in multi-parameter physiology signal acquisition module (10).Meanwhile central processing module (30) receives letter
The digital signal of number processing module (20), central processing module (30) carry out calculating analysis to the digital signal of reception, are differentiating
When Korotkoff's Sound vibration signal is true, based on the delay time information collected by Korotkoff's Sound delay acquisition module (15), through Ke Shi
The calculating of sound delay disposal module (30) delay algorithm, draws the systolic pressure and diastolic pressure of human body artery, and by the result of calculation
The LCD MODULE (40) for being sent to simulation mercury is shown.Central processing module (30) believes the original figure of reception
Number, i.e., the physiological signal of the multi-parameters such as Korotkoff's Sound continuous shaking, pulse wave reaches full waveform recording through USB transmission mode and shows point
Analyse module (60).The raw digital signal of reception can also be stored automatically in memory module (70) by central processing module (30),
The raw digital signal of reception can also be automatically transferred to network module by central processing module (30) in the case of networking
(80), and high in the clouds is reached through network module (80) to preserve.
The LCD MODULE (40) of the simulation mercury is a large-sized liquid crystal display, and display information includes
All kinds of display information such as systolic pressure, diastolic pressure, mean pressure, pulse frequency, test No., simulation mercury, temperature and humidity value, electricity, should
Module (40) can receive the continuous Korotkoff's Sound vibration signal that central processing module (30) calculates analysis, and real in the form of mercury
When be shown on liquid crystal display, convenient for tester's reading.
The control module (50) include multiple key control units, wherein have beginning, stopping, counting, backlight, pattern,
Control instruction, can be issued to central processing module (30) by button, complete data by the buttons such as setting, number, plus-minus
Multiple functions such as typing, acquisition, analysis, arrangement, output.
The full waveform recording shows that analysis module (60) is fixed terminal (61), mobile terminal (62) and portable (hand
Machine or Pad) terminal (63) one or more of combinations, fixed terminal (61) and mobile terminal (62) can be connected by USB
Connect the original life of the mode of central processing module (30) or the continuous shaking that Korotkoff's Sound is obtained from the mode of high in the clouds download of networking
Signal data is managed, and displays data, analyze and arranges.Portable terminal (63) can be networked by APP under high in the clouds
The mode of load obtains the original physiologic signal data of the continuous shaking of the Korotkoff's Sound of network module (80) upload and carries out data and shows
Show.
The memory module (70) receives the Korotkoff's Sound digital signal of central processing module (30) and control module (50) record
All information parameter data such as the subject's essential information entered, memory module (70) can automatic or manual mode data are directly multiple
It makes full waveform recording and shows analysis module (60).The memory module (70) is the internal storage more than or equal to 4G capacity.
The network module (80) receives the Korotkoff's Sound digital signal of central processing module (30) and control module (50) record
Data can be reached high in the clouds and carry out data guarantor by all information parameter data such as the subject's essential information entered, network module (80)
It deposits, this form is the indispensable Important Platform of healthy Internet of Things.
Based on the measuring device of the present invention, measurement blood pressure method is realized, this method is based on detection Korotkoff's Sound vibration signal, energy
The accuracy of blood pressure measurement is improved, is comprised the following steps：
The first step detects the Korotkoff's Sound vibration signal of generated arterial vascular system under blood kinetic energy impact；
Second step determines the Korotkoff's Sound vibration signal in the position of corresponding cardiac cycle, to differentiate that the Korotkoff's Sound vibrates
The authenticity of signal；The authenticity of the signal refers to effectively to judge that Korotkoff's Sound signal is fallen in a complete cardiac cycle,
Just it is considered as authenticity.
Judge that Korotkoff's Sound vibration signal can be according to patent in the position of the corresponding cardiac cycle
The korotkoff's sound delay time proposed in ZL200510071813.0 and ZL20061014107.3 fixes reference point with cardiac cycle
Change function.Such as described in ZL200510071813.0：It " obtains a series of Korotkoff's Sounds according to the complete deflation course of cuff to prolong
Slow time TK and corresponding cuff pressure P values, formation function TK (P), to forming the discrete data progress of the function once or two
Secondary curve matching obtains function TK (P) relation curve that a korotkoff's sound delay time changes with cuff pressure.”；Such as
The description of patent ZL20061014107.3 claims 4：" within each cardiac cycle, by controlling permanent datum to Ke Shi
The time interval of sound arrival moment states korotkoff's sound delay time, korotkoff's sound delay time TK be according to the pressure value of setting and
Real-time pressure value in cuff and the relation curve TK (P) between the korotkoff's sound delay time and blood pressure of calculator memory storage
To obtain.
3rd step obtains Korotkoff's Sound vibration and instantaneous fixed band pressure value occurs；Further, the Korotkoff's Sound vibration
Signal refers to vibration signal produced by velocity of blood flow mutation or impact arterial blood tube wall.
Further, obtaining instantaneous method of the fixation band with pressure value of Korotkoff's Sound vibration generation includes, complete
Korotkoff's Sound vibration signal is first appeared during cardiac cycle, and Korotkoff's Sound vibrates within subsequent n (n >=2) a cardiac cycle
In the case that signal occurs again, Korotkoff's Sound vibration signal moment corresponding fixed band pressure value will be first appeared and be determined as shrinking
Pressure.With the gradual decrease of Korotkoff's Sound vibration signal, when Korotkoff's Sound vibration signal disappears for the first time within a complete cardiac cycle
When, and within subsequent n (n >=2) a cardiac cycle Korotkoff's Sound vibration signal also no longer occur in the case of, Korotkoff's Sound is vibrated
The signal moment corresponding fixed band pressure value that disappears for the first time is determined as diastolic pressure.
Illustrate that the blood pressure measuring device based on the present invention carries out static blood pressure measurement and dynamic below by way of two embodiments
The method of blood pressure measurement.
1 static blood pressure of embodiment measures
1 couple of present invention is described in further details in the following with reference to the drawings and specific embodiments.
1st step：As shown in Figure 1, internal layer fixation band 12 is locked at the one side limbs end of measured, by sensor stabilization
Structure 120 is close at artery, while binds fixed band 11, and preparation starts to test.
Second step：Test is started by the control button on host 1, commencing signal is transferred to fixed band by conducting wire 2
11, charge/discharge gas control unit starts to inflate, and multiple sensor synchronous recordings in multi-parameter physiology signal acquisition module were inflated
Every physiological signal parameter in journey.
Third step：Until korotkoff sound sensor 14 can't detect Korotkoff's Sound vibration signal, stop inflation.Charge/discharge gas
Control unit starts to deflate, the items in multiple sensor synchronous recording deflation courses in multi-parameter physiology signal acquisition module
Physiological signal parameter.
Wherein, the Korotkoff's Sound vibration signal is is produced based on arteries by blood impact and the mutation of velocity of blood flow
Raw faint vibration signal, the vibration signal can be bent by cardiac cycle that the intravascular blood pressure of upper arm artery is formed
Line is measured, and the generation of the vibration is result of the upper arm artery blood vessel with surrounding the interaction of both cuff pressures on upper arm.
It, just can be by stethoscope when the frequency of this vibration falls when human ear hearing threshold frequency scope (20HZ~20KHZ) is interior
It perceives, and the latter is the acoustic information of Korotkoff's Sound vibration.The present invention turns from original simple detection Korotkoff's Sound voice signal
Become detecting Korotkoff's Sound vibration signal, on the one hand more meet the physical essence of Korotkoff's Sound phenomenon, while the pickup of vibration signal
Cheng Buyi is disturbed by environmental noise, therefore is a kind of method of more reliable acquisition Korotkoff's Sound information, the blood pressure measurement measured
Value is also more accurate.
4th step：By fixed with a series of korotkoff's sound delay time T obtained in complete deflation course and corresponding
Fixed band values of pressure p, formation function TK (P)；To forming the discrete data conic fitting of the function, a Korotkoff's Sound is obtained
Time delay T is with fixed TK (P) matched curve (as shown in Figure 8) with pressure P variations.
5th step：With reference to the signal of pulse wave sensor in deflation course 18, determine the Korotkoff's Sound vibration signal in correspondence
The position of cardiac cycle be to determine korotkoff's sound delay time, the present invention is happened at cardiac cycle by Korotkoff's Sound vibration signal
In phase relation differentiate the authenticity of Korotkoff's Sound, the method for the authenticity for differentiating Korotkoff's Sound is to refer to effectively to judge
Korotkoff's Sound signal is fallen in a complete cardiac cycle, can just be differentiated and is considered as authenticity.Wherein, the Korotkoff's Sound delay (Tk)
Refer to the time of Korotkoff's Sound vibration arrival moment in from the fixation reference point consistent with heart beat rhythm to corresponding cardiac cycle, it is described
Permanent datum can be ecg-r wave, pulse wave point of climb etc. (as shown in Figure 9).
6th step：Human body artery systolic pressure and diastolic pressure are judged using the method for korotkoff's sound delay time.Such as 9 institute of attached drawing
Show, between 0.5-1.0s, Korotkoff's Sound vibration signal was first appeared within a complete cardiac cycle, and in subsequent n (n
>=2) in the case that Korotkoff's Sound vibration signal occurs again in a cardiac cycle, the Korotkoff's Sound vibration signal moment pair will be first appeared
The fixed band pressure value answered is determined as systolic pressure.With the gradual decrease of Korotkoff's Sound vibration signal, when Korotkoff's Sound vibration signal is one
When disappearing for the first time in a complete cardiac cycle, and Korotkoff's Sound vibration signal is not yet within subsequent n (n >=2) a cardiac cycle
In the case of occurring again, the Korotkoff's Sound vibration signal moment corresponding fixed band pressure value that disappears for the first time is determined as diastolic pressure (this
Place is not illustrating).
The human blood-pressure measured using the above method avoids the hearing of different people, the difference of resolving power and to spy
The difference (i.e. on the time) in the discrimination of sound is levied, the precision for fundamentally solving Korotkoff's Sound signal extraction, the blood pressure measured
Value also more tallies with the actual situation.
With reference to Fig. 1, based on another aspect of the present invention, a kind of acquisition method for continuous Korotkoff's Sound signal is additionally provided
Carry out the device of blood pressure measurement.
Described device includes：Including multi-parameter physiology signal acquisition module (10), signal processing module (20), central processing
Module (30), the LCD MODULE (40) for simulating mercury, control module (50), full waveform recording show analysis module
(60), memory module (70), network module (80)；Wherein, institute's central processing module (30) receives the control module (50)
Order controls the charge/discharge gas control unit 16 to carry out inflated for deflated operation, the fixed band pressure sensor to fixed band
(13), the cuff pressure signal collected, Korotkoff's Sound vibration signal are sent to signal processing by korotkoff sound sensor (14) respectively
Module (20), the signal processing module (20) are first amplified filtering process to each road signal, then turn by analog signal
The central processing module (30) is sent to after being changed to digital signal, the central processing module (30) carries out received signal
Analysis is calculated, when it is true to differentiate the Korotkoff's Sound vibration signal, by specific functional relation, the Korotkoff's Sound of delay is vibrated
The wave crest and valley value of signal and cuff pressure match, so that it is determined that the diastolic pressure and systolic pressure of human body artery, and this is counted
The LCD MODULE (40) that calculation result is sent to simulation mercury is shown.In addition, the result of measurement can pass through network
Module (80) mode is transmitted to high in the clouds or client (such as computer or mobile phone), summarizes into row information, convenient for the strong of user
Kang Guanli.
2 ambulatory blood pressure of embodiment measures
The testing procedure of the present embodiment and embodiment 1 are consistent, are not repeated herein.
Involved measuring device includes：Multi-parameter physiology signal acquisition module (10), signal processing module (20), center
Processing module (30), control module (50), full waveform recording show analysis module (60), memory module (70), network module
(80).Wherein multi-parameter physiology signal acquisition module (10), signal processing module (20), central processing module (30), control mould
Block (50), memory module (70) and network module (80) are all rationally effectively fixed on outer layer and fix on band (11).The outer layer
There are the information such as display screen energy display working condition and parameter values on fixed band (11).
The operation principle of the present embodiment is as follows.
Fixed band is surrounded at subject's upper arm or the artery at other positions, beginning is assigned by control module (50)
Instruction, inflation/deflation control unit start to be gradually risen or reduced by the code requirement of sphygmomanometer standard with pressure PC to fixed,
During this, central processing unit (30) synchronously detects Korotkoff's Sound vibration, cardiac cycle and fixed band pressure signal, passes through letter
Number relation determines Korotkoff's Sound vibration in the position of corresponding cardiac cycle, i.e. Korotkoff's Sound delay pre-value, then confirm and really belong to completely
A PB cardiac cycle under the conditions of, human body artery systolic pressure Ps values and diastolic pressure are judged using the method for korotkoff's sound delay time
Pd values.
Every the time interval that half an hour or advance doctor set, multi-parameter physiology signal acquisition module (10) is by shaking
Dynamic prompting subject prepares test next time, while moving state identification module (19) starts the physical condition of identification subject, such as quilt
Body have a fitting still in motion state, multi-parameter physiology signal acquisition module (10) continues through vibration prompt subject and prepares to survey
Examination just can assign sign on until subject body remains static by control module (50)；Such as it is tested body still
It remains static, at once control module (50) is notified to assign sign on, and it is complete according to the gatherer process of ambulatory blood pressure for the first time
Into the acquisition of second of ambulatory blood pressure.
Remaining blood pressure acquisition persistently carries out as procedure described above, blood pressure dynamic acquisition procedures when completion 24 is small.
All ambulatory blood pressure data collected can be used a variety of upload modes and data reached high in the clouds or client,
Shown method for uploading sends, transmits including constant duration, surveying i.e. hair etc..The client refers to that full waveform recording is shown
Show analysis module (60), which includes analysis software, can according to test data to subject ABP levels, blood pressure variability,
The information such as circadian rhythm are automatically analyzed and recorded.
The present invention by continuous acquisition to Korotkoff's Sound vibration signal, to the detection of heart cycle waveform, with pressure to fixation
The extraction of force signal realizes accurate acquisition pressure value.Compared to original " goldstandard ", the physics generated closer to Korotkoff's Sound
Essence, therefore result is more accurate.It is possible that distinguishing the real systolic pressure value of blood pressure virtual height person, hospital can be solved for these years
Lack the electronic sphygmomanometer for meeting healthy medical clinic applications, be even more the indispensable Important Platform of healthy Internet of Things.It can push away
Extensively to family, family's result of testing oneself is made to be in hospital's measurement result on same normal line.Due to the present invention develop originating from pair
Korotkoff's Sound generates the research of bio-physical property, therefore can develop into physical standard, standardization property with the present invention
The blood pressure objective record instrument of matter.
It is worth noting that, the foregoing is merely presently preferred embodiments of the present invention, the patent of the present invention is not thereby limited
Protection domain, the present invention can also carry out the improvement of material and structure or using skill to the construction of above-mentioned various parts
Art equivalent is replaced.Therefore it is all with the present invention specification and diagramatic content made equivalent structure variation or directly or
Apply to other correlative technology fields indirectly to be similarly all contained in the range of of the invention cover.
Claims (5)
1. a kind of blood pressure measuring device, being capable of continuous acquisition and record Korotkoff's Sound physiological vibrations signal and other physiological signals ginseng
Number, it is characterised in that：Including multi-parameter physiology signal acquisition module (10), signal processing module (20), central processing module
(30), LCD MODULE (40), control module (50), full waveform recording show analysis module (60), memory module (70), net
Network module (80)；
The multi-parameter physiology signal acquisition module (10) includes outer layer fixation band (11), internal layer fixes band (12), fixation is with pressure
It is force snesor (13), korotkoff sound sensor (14), Korotkoff's Sound delay acquisition module (15), charge/discharge gas control unit (16), warm and humid
Spend sensor (17), pulse wave sensor (18) and moving state identification module (19)；
The display information of the LCD MODULE (40) includes systolic pressure, diastolic pressure, mean pressure, pulse frequency, test No., simulation
Mercury, temperature and humidity value, electricity, the LCD MODULE (40) receive the continuous Ke Shi that central processing module (30) calculates analysis
Sound vibration signal, and with the graphical display of mercury；
The control module (50) includes multiple key control units, including starting, stopping, counting, backlight, pattern, setting, volume
Number, plus-minus button, control instruction can be sent to by button by central processing module (30), complete the typings of data, acquisition,
Analysis is arranged and exported；
The full waveform recording shows analysis module (60) for fixed terminal (61) and/or mobile terminal (62) and/or portable
Terminal (63)；
The memory module (70) receives the Korotkoff's Sound digital signal of central processing module (30) and control module (50) typing
All information parameter data, memory module (70) can automatic or manual mode copy data to full waveform recording display analysis mould
Block (60)；
The network module (80) receives the Korotkoff's Sound digital signal of central processing module (30) and control module (50) typing
Data can be reached high in the clouds and carry out data preservation by all information parameter data, network module (80)；
Sensor stabilization structure (120) is further included, is fixed on the inside that internal layer fixes band；Sensor stabilization structure (120) is wrapped
Include carbon fiber diaphragm (121), fixed sleeve part (123), fixed rubber ring fastener (124) and square foam stabilizing member (125)；
Sensor is fixed in rubber ring by fixed sleeve part (123) and fixed rubber ring fastener (124), square foam stabilizing member
(125) by carbon fiber diaphragm (121) and fixed rubber ring fastener (124) be fixed therein between circular trough in.
2. blood pressure measuring device as described in claim 1, it is characterised in that：Fixed band pressure sensor (13) is used to identify fixation
Pressure signal is reached central processing module (50) by the pressure characteristic to human contact face of band through signal processing module (20),
Outer layer is carried out by central processing module (50) control charge/discharge gas control unit (16) and fixes the inflation/deflation process with (11).
3. blood pressure measuring device as described in claim 1, it is characterised in that：Institute under korotkoff sound sensor detection blood kinetic energy impact
Signal is reached Korotkoff's Sound delay acquisition module (15), the module by the Korotkoff's Sound vibration signal of the arterial vascular system of generation
(15) reached after the physiological signal that korotkoff sound sensor (14) gathers is handled by default algorithm and formula to signal
Processing module (20).
4. blood pressure measuring device as described in claim 1, it is characterised in that：The fixed band of Temperature Humidity Sensor (17) acquisition and skin
The humiture information of contact surface, the vibration of pulse wave sensor (18) and korotkoff sound sensor (14) synchronous recording human pulse ripple
Signal.
5. blood pressure measuring device as described in claim 1, it is characterised in that：Central processing module (30) is by the original figure of reception
Signal reaches full waveform recording display analysis module (60) through USB transmission mode or is stored automatically in memory module (70) or incites somebody to action
The raw digital signal of reception is automatically transferred to network module (80), and reaches high in the clouds through network module (80) and preserve.
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| CN105942980B (en) * | 2016-05-30 | 2019-11-26 | 珠海脉动时代健康科技有限公司 | A kind of method and system of stethoscopy sphygmomanometer feature extraction and classification |
| CN107348954A (en) * | 2016-08-09 | 2017-11-17 | 吕晓东 | Sphygmomanometer |
| CN112512416A (en) * | 2018-09-27 | 2021-03-16 | 湖南帕斯沃生物科技有限公司 | Device and method for automatic identification of Korotkoff sounds and/or bioacoustic signals using an optical stethoscope |
| CN109864731B (en) * | 2018-12-28 | 2022-07-01 | 北京津发科技股份有限公司 | Pulse measuring method and device, terminal equipment and readable storage medium |
| CN110720902B (en) * | 2019-11-07 | 2022-08-16 | 浙江华诺康科技有限公司 | Blood pressure measuring method and sphygmomanometer |
| CN112603262A (en) * | 2020-12-02 | 2021-04-06 | 珠海中科先进技术研究院有限公司 | Human body state identification method, system and medium |
| CN113297922B (en) * | 2021-04-30 | 2023-05-05 | 广西电网有限责任公司电力科学研究院 | High-voltage switch cabinet fault diagnosis method, device and storage medium |
| CN114587314A (en) * | 2022-02-28 | 2022-06-07 | 深圳市景新浩科技有限公司 | Internet blood pressure measuring device and control method thereof |
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