JP2007536279A5 - - Google Patents
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- Publication number
- JP2007536279A5 JP2007536279A5 JP2007511722A JP2007511722A JP2007536279A5 JP 2007536279 A5 JP2007536279 A5 JP 2007536279A5 JP 2007511722 A JP2007511722 A JP 2007511722A JP 2007511722 A JP2007511722 A JP 2007511722A JP 2007536279 A5 JP2007536279 A5 JP 2007536279A5
- Authority
- JP
- Japan
- Prior art keywords
- random copolymer
- dose
- yfak
- phenylalanine
- pharmaceuticals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920005604 random copolymer Polymers 0.000 claims 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims 1
- 235000019766 L-Lysine Nutrition 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 229960003767 alanine Drugs 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 229960004441 tyrosine Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000000034 method Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56929204P | 2004-05-07 | 2004-05-07 | |
| US60/569,292 | 2004-05-07 | ||
| US66333305P | 2005-03-18 | 2005-03-18 | |
| US60/663,333 | 2005-03-18 | ||
| PCT/US2005/016344 WO2005112972A1 (en) | 2004-05-07 | 2005-05-09 | Methods of treating disease with random copolymers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012044246A Division JP5892815B2 (ja) | 2004-05-07 | 2012-02-29 | ランダム共重合体を用いる疾患の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007536279A JP2007536279A (ja) | 2007-12-13 |
| JP2007536279A5 true JP2007536279A5 (https=) | 2012-06-14 |
| JP5495490B2 JP5495490B2 (ja) | 2014-05-21 |
Family
ID=35159680
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007511722A Expired - Fee Related JP5495490B2 (ja) | 2004-05-07 | 2005-05-09 | ランダム共重合体を用いる疾患の治療方法 |
| JP2007511720A Pending JP2007536278A (ja) | 2004-05-07 | 2005-05-09 | ランダム共重合体を用いる疾患の治療方法 |
| JP2012044246A Expired - Fee Related JP5892815B2 (ja) | 2004-05-07 | 2012-02-29 | ランダム共重合体を用いる疾患の治療方法 |
| JP2012216951A Withdrawn JP2012255034A (ja) | 2004-05-07 | 2012-09-28 | ランダム共重合体を用いる疾患の治療方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007511720A Pending JP2007536278A (ja) | 2004-05-07 | 2005-05-09 | ランダム共重合体を用いる疾患の治療方法 |
| JP2012044246A Expired - Fee Related JP5892815B2 (ja) | 2004-05-07 | 2012-02-29 | ランダム共重合体を用いる疾患の治療方法 |
| JP2012216951A Withdrawn JP2012255034A (ja) | 2004-05-07 | 2012-09-28 | ランダム共重合体を用いる疾患の治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| EP (3) | EP1750741B1 (https=) |
| JP (4) | JP5495490B2 (https=) |
| KR (1) | KR20070036062A (https=) |
| AU (2) | AU2005251686B2 (https=) |
| BR (1) | BRPI0510738A (https=) |
| CA (2) | CA2565819A1 (https=) |
| ES (1) | ES2560448T3 (https=) |
| IL (2) | IL179074A0 (https=) |
| MX (1) | MXPA06012864A (https=) |
| NZ (1) | NZ551236A (https=) |
| RU (1) | RU2410115C2 (https=) |
| WO (2) | WO2005120542A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060125916A (ko) * | 2004-03-01 | 2006-12-06 | 펩팀문, 인코포레이티드 | 자가면역 질병을 치료하기 위한 방법 및 조성물 |
| US7655221B2 (en) | 2004-05-07 | 2010-02-02 | Peptimmune, Inc. | Methods of treating disease with random copolymers |
| US20060194725A1 (en) * | 2004-05-07 | 2006-08-31 | James Rasmussen | Methods of treating disease with random copolymers |
| EP2016095A2 (en) * | 2006-04-13 | 2009-01-21 | Peptimmune, Inc. | Methods for designing and synthesizing directed sequence polymer compositions via the directed expansion of epitope permeability |
| BRPI0817682A2 (pt) | 2007-10-16 | 2015-04-07 | Peptimmune Inc | Métodos para projetar e preparar vacinas compreendendo composições de polímero de sequência direcionada via a expansão direta de epítopos |
| WO2009128948A1 (en) | 2008-04-17 | 2009-10-22 | Peptimmune, Inc. | Design and synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders |
| US20120237472A1 (en) * | 2009-07-24 | 2012-09-20 | The Johns Hopkins University | Methods and compositions for treating or preventing autoimmune diseases using immunomodulatory agents |
| ES2612001T4 (es) | 2009-08-20 | 2018-02-07 | Yeda Research & Development Company, Ltd. | Terapia de baja frecuencia con acetato de glatirámero |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| EP3478316A1 (en) * | 2016-07-01 | 2019-05-08 | Declion Holdings LLC | Amino acid copolymer compositions and uses thereof |
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| HUE071047T2 (hu) | 2016-08-31 | 2025-07-28 | Mapi Pharma Ltd | Glatiramer-acetátot tartalmazó depórendszerek |
| CN110382052A (zh) | 2017-03-26 | 2019-10-25 | Mapi医药公司 | 用于治疗进展型形式的多发性硬化症的格拉替雷储库系统 |
| US20230414732A1 (en) | 2020-11-10 | 2023-12-28 | Palena Therapeutics, Inc. | Compositions of embedded epitope random peptides (eerp) for treatment of immune-mediated conditions, and methods of use |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL36670A (en) | 1971-04-21 | 1974-09-10 | Sela M | Therapeutic basic copolymers of amino acids |
| IL113812A (en) | 1994-05-24 | 2000-06-29 | Yeda Res & Dev | Copolymer-1 pharmaceutical compositions containing it and its use |
| US5858964A (en) | 1995-04-14 | 1999-01-12 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD |
| US6515016B2 (en) * | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| JPH11330431A (ja) | 1998-05-18 | 1999-11-30 | Nec Corp | 不揮発性半導体記憶装置の製造方法 |
| JP2003521448A (ja) | 1998-07-23 | 2003-07-15 | ザ・プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ | 合成ペプチドおよび自己免疫疾患治療のための使用方法 |
| JP4800481B2 (ja) * | 1998-07-23 | 2011-10-26 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 共重合体１および関連する共重合体ならびにペプチドによる自己免疫疾患の治療 |
| WO2000005250A1 (en) | 1998-07-23 | 2000-02-03 | Yeda Research And Development Co., Ltd | Treatment of autoimmune conditions with copolymer 1 and related copolymers and peptides |
| US6514938B1 (en) | 1998-09-25 | 2003-02-04 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
| CA2355400A1 (en) | 1998-11-12 | 2000-05-18 | Yeda Research And Development Co., Ltd. | Pharmaceutical compositions comprising synthetic peptide copolymers and methods for preventing and treating gvhd and hvgd |
| PT1248643E (pt) * | 2000-01-20 | 2005-10-31 | Yeda Res & Dev | Utilizacao de copolimero 1 e peptidos e polipeptidos congeneres e de celulas t tratadas co estes compostos para terapia neuroprotectora |
| DK1294390T3 (da) | 2000-06-07 | 2006-04-03 | Yeda Res & Dev | Anvendelse af copolymer 1 og beslægtede peptider og polypeptider og T-celelr behandlet dermed til neurobeskyttelse mod glutamattoksicitet |
| US20040003888A1 (en) | 2000-07-11 | 2004-01-08 | Laurence Mott | Process for the manufacture of an improved floor element |
| US6930168B2 (en) | 2001-01-24 | 2005-08-16 | The President And Fellows Of Harvard College | Synthetic peptides for demyelinating conditions |
| US6849426B2 (en) * | 2001-06-28 | 2005-02-01 | Cambrex Bio Science Walkersville, Inc. | Methods and reagents for detecting endotoxin |
| CA2614171C (en) * | 2001-10-03 | 2012-04-24 | President And Fellows Of Harvard College | Copolymers for suppression of autoimmune diseases, and methods of use |
| IL161121A0 (en) * | 2001-10-03 | 2004-08-31 | Harvard College | Copolymers for suppression of autoimmune diseases, and methods of use |
| IL160105A0 (en) * | 2001-12-06 | 2004-06-20 | Yeda Res & Dev | Vaccine for treatment of motor neurone diseases |
| NZ569331A (en) * | 2003-01-21 | 2010-08-27 | Yeda Res & Dev | COP 1 for treatment of inflammatory bowel diseases |
-
2005
- 2005-05-09 KR KR1020067025802A patent/KR20070036062A/ko not_active Ceased
- 2005-05-09 AU AU2005251686A patent/AU2005251686B2/en not_active Ceased
- 2005-05-09 ES ES05779362.2T patent/ES2560448T3/es not_active Expired - Lifetime
- 2005-05-09 BR BRPI0510738-5A patent/BRPI0510738A/pt not_active IP Right Cessation
- 2005-05-09 EP EP05779362.2A patent/EP1750741B1/en not_active Expired - Lifetime
- 2005-05-09 EP EP12174215A patent/EP2508194A1/en not_active Withdrawn
- 2005-05-09 CA CA002565819A patent/CA2565819A1/en not_active Abandoned
- 2005-05-09 NZ NZ551236A patent/NZ551236A/en not_active IP Right Cessation
- 2005-05-09 RU RU2006143334/15A patent/RU2410115C2/ru not_active IP Right Cessation
- 2005-05-09 EP EP05783041A patent/EP1750742A2/en not_active Withdrawn
- 2005-05-09 WO PCT/US2005/016340 patent/WO2005120542A2/en not_active Ceased
- 2005-05-09 MX MXPA06012864A patent/MXPA06012864A/es active IP Right Grant
- 2005-05-09 WO PCT/US2005/016344 patent/WO2005112972A1/en not_active Ceased
- 2005-05-09 JP JP2007511722A patent/JP5495490B2/ja not_active Expired - Fee Related
- 2005-05-09 AU AU2005244814A patent/AU2005244814B2/en not_active Ceased
- 2005-05-09 JP JP2007511720A patent/JP2007536278A/ja active Pending
- 2005-05-09 CA CA002565703A patent/CA2565703A1/en not_active Abandoned
-
2006
- 2006-11-06 IL IL179074A patent/IL179074A0/en unknown
- 2006-11-06 IL IL179075A patent/IL179075A/en not_active IP Right Cessation
-
2012
- 2012-02-29 JP JP2012044246A patent/JP5892815B2/ja not_active Expired - Fee Related
- 2012-09-28 JP JP2012216951A patent/JP2012255034A/ja not_active Withdrawn
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