JP2007536279A5 - - Google Patents
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- Publication number
- JP2007536279A5 JP2007536279A5 JP2007511722A JP2007511722A JP2007536279A5 JP 2007536279 A5 JP2007536279 A5 JP 2007536279A5 JP 2007511722 A JP2007511722 A JP 2007511722A JP 2007511722 A JP2007511722 A JP 2007511722A JP 2007536279 A5 JP2007536279 A5 JP 2007536279A5
- Authority
- JP
- Japan
- Prior art keywords
- random copolymer
- dose
- yfak
- phenylalanine
- pharmaceuticals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920005604 random copolymer Polymers 0.000 claims 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims 1
- 235000019766 L-Lysine Nutrition 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 229960003767 alanine Drugs 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 229960004441 tyrosine Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000000034 method Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56929204P | 2004-05-07 | 2004-05-07 | |
| US60/569,292 | 2004-05-07 | ||
| US66333305P | 2005-03-18 | 2005-03-18 | |
| US60/663,333 | 2005-03-18 | ||
| PCT/US2005/016344 WO2005112972A1 (en) | 2004-05-07 | 2005-05-09 | Methods of treating disease with random copolymers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012044246A Division JP5892815B2 (ja) | 2004-05-07 | 2012-02-29 | ランダム共重合体を用いる疾患の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007536279A JP2007536279A (ja) | 2007-12-13 |
| JP2007536279A5 true JP2007536279A5 (https=) | 2012-06-14 |
| JP5495490B2 JP5495490B2 (ja) | 2014-05-21 |
Family
ID=35159680
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007511722A Expired - Fee Related JP5495490B2 (ja) | 2004-05-07 | 2005-05-09 | ランダム共重合体を用いる疾患の治療方法 |
| JP2007511720A Pending JP2007536278A (ja) | 2004-05-07 | 2005-05-09 | ランダム共重合体を用いる疾患の治療方法 |
| JP2012044246A Expired - Fee Related JP5892815B2 (ja) | 2004-05-07 | 2012-02-29 | ランダム共重合体を用いる疾患の治療方法 |
| JP2012216951A Withdrawn JP2012255034A (ja) | 2004-05-07 | 2012-09-28 | ランダム共重合体を用いる疾患の治療方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007511720A Pending JP2007536278A (ja) | 2004-05-07 | 2005-05-09 | ランダム共重合体を用いる疾患の治療方法 |
| JP2012044246A Expired - Fee Related JP5892815B2 (ja) | 2004-05-07 | 2012-02-29 | ランダム共重合体を用いる疾患の治療方法 |
| JP2012216951A Withdrawn JP2012255034A (ja) | 2004-05-07 | 2012-09-28 | ランダム共重合体を用いる疾患の治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| EP (3) | EP2508194A1 (https=) |
| JP (4) | JP5495490B2 (https=) |
| KR (1) | KR20070036062A (https=) |
| AU (2) | AU2005244814B2 (https=) |
| BR (1) | BRPI0510738A (https=) |
| CA (2) | CA2565703A1 (https=) |
| ES (1) | ES2560448T3 (https=) |
| IL (2) | IL179074A0 (https=) |
| MX (1) | MXPA06012864A (https=) |
| NZ (1) | NZ551236A (https=) |
| RU (1) | RU2410115C2 (https=) |
| WO (2) | WO2005120542A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005219876A1 (en) * | 2004-03-01 | 2005-09-15 | Peptimmune, Inc. | Methods and compositions for treatment of autoimmune diseases |
| US20060194725A1 (en) * | 2004-05-07 | 2006-08-31 | James Rasmussen | Methods of treating disease with random copolymers |
| US7655221B2 (en) | 2004-05-07 | 2010-02-02 | Peptimmune, Inc. | Methods of treating disease with random copolymers |
| US8378072B2 (en) | 2006-04-13 | 2013-02-19 | Declion Pharmaceuticals, Inc. | Methods for designing and synthesizing directed sequence polymer compositions via the directed expansion of epitope permeability |
| AP3467A (en) | 2007-10-16 | 2015-11-30 | Peptimmune Inc | Methods for designing and preparing vaccines comprising directed sequence polymer compositions via the directed expansion of epitopes |
| WO2009128948A1 (en) | 2008-04-17 | 2009-10-22 | Peptimmune, Inc. | Design and synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders |
| WO2011011706A2 (en) * | 2009-07-24 | 2011-01-27 | The Johns Hopkins University | Methods and compositions for treating or preventing autoimmune diseases using immunomodulatory agents |
| NZ598661A (en) | 2009-08-20 | 2013-02-22 | Yeda Res & Dev | Low frequency glatiramer acetate therapy |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| CA3029654A1 (en) * | 2016-07-01 | 2018-01-04 | Declion Holdings Llc | Amino acid copolymer compositions and uses thereof |
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| CN109982712A (zh) | 2016-08-31 | 2019-07-05 | Mapi医药公司 | 包含醋酸格拉替雷的储库系统 |
| CN110382052A (zh) | 2017-03-26 | 2019-10-25 | Mapi医药公司 | 用于治疗进展型形式的多发性硬化症的格拉替雷储库系统 |
| IL302604A (en) | 2020-11-10 | 2023-07-01 | Palena Therapeutics Inc | Epitope-Encapsulated Random Peptide (EERP) Preparations for the Treatment of Immune-Mediated Conditions and Methods of Use |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL36670A (en) | 1971-04-21 | 1974-09-10 | Sela M | Therapeutic basic copolymers of amino acids |
| IL113812A (en) | 1994-05-24 | 2000-06-29 | Yeda Res & Dev | Copolymer-1 pharmaceutical compositions containing it and its use |
| US5858964A (en) | 1995-04-14 | 1999-01-12 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD |
| US6515016B2 (en) * | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| JPH11330431A (ja) | 1998-05-18 | 1999-11-30 | Nec Corp | 不揮発性半導体記憶装置の製造方法 |
| IL141021A0 (en) | 1998-07-23 | 2002-02-10 | Yeda Res & Dev | Treatment of autoimmune conditions with copolymer 1 and related copolymers |
| HUP0202653A3 (en) * | 1998-07-23 | 2007-11-28 | Yeda Res & Dev | Treatment of autoimmune conditions with copolymer 1 and related copolymers peptides |
| WO2000005249A2 (en) | 1998-07-23 | 2000-02-03 | The President And Fellows Of Harvard College | Synthetic peptides and methods of use for autoimmune disease therapies |
| US6514938B1 (en) | 1998-09-25 | 2003-02-04 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
| AU775073C (en) * | 1998-11-12 | 2007-05-03 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising synthetic peptide copolymers and methods for preventing and treating GVHD and HVGD |
| JP4328050B2 (ja) * | 2000-01-20 | 2009-09-09 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 神経保護療法のためのコポリマー１、関連ペプチド及びポリペプチドならびにそれらによって処理されたｔ細胞の使用 |
| EP1294390B1 (en) | 2000-06-07 | 2006-01-04 | YEDA RESEARCH AND DEVELOPMENT CO., Ltd. | The use of copolymer 1 and related peptides and polypeptides and t cells treated therewith for neuroprotection from glutamate toxicity |
| US20040003888A1 (en) | 2000-07-11 | 2004-01-08 | Laurence Mott | Process for the manufacture of an improved floor element |
| IL157073A0 (en) | 2001-01-24 | 2004-02-08 | Harvard College | Therapeutic peptides for demyelinating conditions |
| US20040235080A1 (en) * | 2001-06-28 | 2004-11-25 | Lin Chen | Methods and reagents for detecting endotoxin |
| CA2614171C (en) * | 2001-10-03 | 2012-04-24 | President And Fellows Of Harvard College | Copolymers for suppression of autoimmune diseases, and methods of use |
| DE02800437T1 (de) * | 2001-10-03 | 2004-11-11 | The President And Fellows Of Harvard College, Cambridge | Copolymere zur unterdrückung von autoimmunkrankheiten und anwendungsverfahren |
| US7351686B2 (en) * | 2001-12-06 | 2008-04-01 | Yeda Research And Development Co. Ltd. | Method for neuronal protection in amyotrophic lateral sclerosis by a vaccine comprising Copolymer-1 or Copolymer-1 related peptides |
| RU2339397C2 (ru) * | 2003-01-21 | 2008-11-27 | Йеда Рисерч Энд Дивелопмент Ко.Лтд. | Сор1 для лечения воспалительных заболеваний кишечника |
-
2005
- 2005-05-09 JP JP2007511722A patent/JP5495490B2/ja not_active Expired - Fee Related
- 2005-05-09 BR BRPI0510738-5A patent/BRPI0510738A/pt not_active IP Right Cessation
- 2005-05-09 EP EP12174215A patent/EP2508194A1/en not_active Withdrawn
- 2005-05-09 JP JP2007511720A patent/JP2007536278A/ja active Pending
- 2005-05-09 KR KR1020067025802A patent/KR20070036062A/ko not_active Ceased
- 2005-05-09 CA CA002565703A patent/CA2565703A1/en not_active Abandoned
- 2005-05-09 NZ NZ551236A patent/NZ551236A/en not_active IP Right Cessation
- 2005-05-09 WO PCT/US2005/016340 patent/WO2005120542A2/en not_active Ceased
- 2005-05-09 AU AU2005244814A patent/AU2005244814B2/en not_active Ceased
- 2005-05-09 ES ES05779362.2T patent/ES2560448T3/es not_active Expired - Lifetime
- 2005-05-09 EP EP05783041A patent/EP1750742A2/en not_active Withdrawn
- 2005-05-09 EP EP05779362.2A patent/EP1750741B1/en not_active Expired - Lifetime
- 2005-05-09 MX MXPA06012864A patent/MXPA06012864A/es active IP Right Grant
- 2005-05-09 WO PCT/US2005/016344 patent/WO2005112972A1/en not_active Ceased
- 2005-05-09 AU AU2005251686A patent/AU2005251686B2/en not_active Ceased
- 2005-05-09 CA CA002565819A patent/CA2565819A1/en not_active Abandoned
- 2005-05-09 RU RU2006143334/15A patent/RU2410115C2/ru not_active IP Right Cessation
-
2006
- 2006-11-06 IL IL179074A patent/IL179074A0/en unknown
- 2006-11-06 IL IL179075A patent/IL179075A/en not_active IP Right Cessation
-
2012
- 2012-02-29 JP JP2012044246A patent/JP5892815B2/ja not_active Expired - Fee Related
- 2012-09-28 JP JP2012216951A patent/JP2012255034A/ja not_active Withdrawn
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