JP2007533706A - 喫煙患者における呼吸器疾患の治療のためのシクレソニドの使用 - Google Patents
喫煙患者における呼吸器疾患の治療のためのシクレソニドの使用 Download PDFInfo
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- JP2007533706A JP2007533706A JP2007508906A JP2007508906A JP2007533706A JP 2007533706 A JP2007533706 A JP 2007533706A JP 2007508906 A JP2007508906 A JP 2007508906A JP 2007508906 A JP2007508906 A JP 2007508906A JP 2007533706 A JP2007533706 A JP 2007533706A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56346404P | 2004-04-20 | 2004-04-20 | |
| PCT/EP2005/051718 WO2005102354A1 (en) | 2004-04-20 | 2005-04-19 | Use of ciclesonide for the treatment of respiratory diseases in a smoking patient |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007533706A true JP2007533706A (ja) | 2007-11-22 |
| JP2007533706A5 JP2007533706A5 (enExample) | 2012-08-09 |
Family
ID=34967481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007508906A Pending JP2007533706A (ja) | 2004-04-20 | 2005-04-19 | 喫煙患者における呼吸器疾患の治療のためのシクレソニドの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070134165A1 (enExample) |
| EP (1) | EP1740188A1 (enExample) |
| JP (1) | JP2007533706A (enExample) |
| AU (1) | AU2005235384B2 (enExample) |
| CA (1) | CA2563556C (enExample) |
| WO (1) | WO2005102354A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2844944A1 (en) | 2011-08-18 | 2013-02-21 | Takeda Gmbh | Pharmaceutical aerosol product for administration by oral or nasal inhalation |
| SI2934479T1 (sl) | 2012-12-21 | 2019-01-31 | Boehringer Ingelheim Vetmedica Gmbh | Ciklezonid za zdravljenje bolezni dihalnih poti pri konjih |
| ES2706757T3 (es) | 2012-12-21 | 2019-04-01 | Boehringer Ingelheim Vetmedica Gmbh | Formulación farmacéutica que comprende ciclesonida |
| ES2759247T3 (es) | 2014-06-18 | 2020-05-08 | Boehringer Ingelheim Vetmedica Gmbh | Antagonistas muscarínicos y combinaciones de estos para el tratamiento de enfermedades de las vías respiratorias en caballos |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002512193A (ja) * | 1998-04-20 | 2002-04-23 | アストラゼネカ・アクチエボラーグ | 軽度／初期型のｃｏｐｄ（慢性閉塞性肺疾患）を処置することを目的とした薬物の製造のための糖質副腎皮質ステロイドの使用 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3166396D1 (en) * | 1980-02-27 | 1984-11-08 | Tate & Lyle Plc | Crystalline glucose and process for its production |
| US4816445A (en) * | 1984-06-21 | 1989-03-28 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Crystalline alpha-maltose |
| JP2518646B2 (ja) * | 1987-05-29 | 1996-07-24 | 株式会社 林原生物化学研究所 | マルト−ス粉末の製造方法 |
| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US6536427B2 (en) * | 1990-03-02 | 2003-03-25 | Glaxo Group Limited | Inhalation device |
| US5178866A (en) * | 1990-03-23 | 1993-01-12 | Alza Corporation | Dosage form for delivering drug to the intestine |
| GR1001529B (el) * | 1990-09-07 | 1994-03-31 | Elmuquimica Farm Sl | Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης. |
| US5434304A (en) * | 1990-09-26 | 1995-07-18 | Aktiebolaget Astra | Process for preparing formoterol and related compounds |
| AU650953B2 (en) * | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
| US6866839B2 (en) * | 1991-04-05 | 2005-03-15 | Sepracor Inc. | Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol |
| US5795564A (en) * | 1991-04-05 | 1998-08-18 | Sepracor, Inc. | Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol |
| HUT67449A (en) * | 1991-06-10 | 1995-04-28 | Schering Corp | Aerosol formulations containing 1,1,1,2,3,3,3-heptafluoropropane |
| IT1250691B (it) * | 1991-07-22 | 1995-04-21 | Giancarlo Santus | Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac. |
| HU220868B1 (en) * | 1993-04-02 | 2002-06-29 | Byk Gulden Lomberg Chem Fab | New prednisolone derivative, process for its production, use of the same and pharmaceutical composition containing the same |
| US5811388A (en) * | 1995-06-07 | 1998-09-22 | Cibus Pharmaceutical, Inc. | Delivery of drugs to the lower GI tract |
| AU6111796A (en) * | 1995-06-12 | 1997-01-09 | G.D. Searle & Co. | Compositions comprising a cyclooxygenase-2 inhibitor and a 5 -lipoxygenase inhibitor |
| CA2228953A1 (en) * | 1995-09-26 | 1997-04-03 | Takeda Chemical Industries, Ltd. | Phosphorylamides, their preparation and use |
| US6380222B2 (en) * | 1996-10-11 | 2002-04-30 | Astrazeneca Ab | Use of an H+, K+-atpase inhibitor in the treatment of nasal polyps |
| FR2754712B1 (fr) * | 1996-10-17 | 1999-09-03 | Merck Sharp Dohme Chibret Lab | Compositions ophtalmiques |
| US6613795B2 (en) * | 1996-11-11 | 2003-09-02 | Christian Noe | Enantiomerically pure basic arylcycloalkylhydroxycarboxylic esters, processes for their preparation and their use in medicaments |
| SE9700135D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| US20020111495A1 (en) * | 1997-04-04 | 2002-08-15 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
| US6120752A (en) * | 1997-05-21 | 2000-09-19 | 3M Innovative Properties Company | Medicinal aerosol products containing formulations of ciclesonide and related steroids |
| GB2329939A (en) * | 1997-06-26 | 1999-04-07 | Glaxo Group Ltd | Self-lubricating valve stem for aerosol containers |
| SE9704186D0 (sv) * | 1997-11-14 | 1997-11-14 | Astra Ab | New composition of matter |
| WO1999031073A1 (en) * | 1997-12-15 | 1999-06-24 | Yamanouchi Pharmaceutical Co., Ltd. | Novel pyrimidine-5-carboxamide derivatives |
| TWI243687B (en) * | 1998-04-21 | 2005-11-21 | Teijin Ltd | Pharmaceutical composition for application to mucosa |
| US6264923B1 (en) * | 1998-05-13 | 2001-07-24 | 3M Innovative Properties Company | Medicinal aerosol formulation of ciclesonide and related compounds |
| US6241969B1 (en) * | 1998-06-26 | 2001-06-05 | Elan Corporation Plc | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
| US6585958B1 (en) * | 1998-07-24 | 2003-07-01 | Jago Research Ag | Medicinal aerosol formulations |
| DK1102579T3 (da) * | 1998-08-04 | 2003-07-14 | Jago Res Ag | Medicinske aerosolformuleringer |
| RU2221552C2 (ru) * | 1998-11-13 | 2004-01-20 | Джаго Рисерч Аг | Сухой порошок для ингаляции |
| US6397838B1 (en) * | 1998-12-23 | 2002-06-04 | Battelle Pulmonary Therapeutics, Inc. | Pulmonary aerosol delivery device and method |
| US6124268A (en) * | 1999-02-17 | 2000-09-26 | Natreon Inc. | Natural antioxidant compositions, method for obtaining same and cosmetic, pharmaceutical and nutritional formulations thereof |
| US6454193B1 (en) * | 1999-04-23 | 2002-09-24 | Battellepharma, Inc. | High mass transfer electrosprayer |
| WO2000064590A1 (en) * | 1999-04-23 | 2000-11-02 | Battelle Memorial Institute | Directionally controlled ehd aerosol sprayer |
| AR026072A1 (es) * | 1999-10-20 | 2002-12-26 | Nycomed Gmbh | Composicion farmaceutica que contiene ciclesonida para aplicacion a la mucosa |
| DE10062712A1 (de) * | 2000-12-15 | 2002-06-20 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden |
| US20020183292A1 (en) * | 2000-10-31 | 2002-12-05 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and corticosteroids |
| WO2002038155A1 (en) * | 2000-11-07 | 2002-05-16 | Merck & Co., Inc. | Method of treatment with a combination of a pde4 inhibitor and a leukotriene antagonist |
| ES2656210T3 (es) * | 2000-12-22 | 2018-02-26 | Glaxo Group Limited | Inhalador dosificador para xinafoato de salmeterol |
| RU2279292C2 (ru) * | 2001-10-24 | 2006-07-10 | Пари Гмбх | Набор для приготовления фармацевтической композиции |
| CA2467035A1 (en) * | 2001-11-17 | 2003-05-30 | Aventis Pharma Limited | Pharmaceutical product with an adsorbent |
| CA2467652A1 (en) * | 2001-11-19 | 2003-05-30 | Altana Pharma Ag | Reversible proton pump inhibitors for the treatment of airway disorders |
| ITMI20020808A1 (it) * | 2002-04-17 | 2003-10-17 | Chiesi Farma Spa | Procedimento per la preparazione di una sospensione sterile di particelle di beclometasone dipropionato da somministrare per inalazione |
| EP1519734A4 (en) * | 2002-07-02 | 2011-02-23 | Nycomed Gmbh | CICLESONIC STERILE AQUEOUS SUSPENSION |
| US8371292B2 (en) * | 2003-09-16 | 2013-02-12 | Nycomed Gmbh | Use of ciclesonide for the treatment of respiratory diseases |
-
2005
- 2005-04-19 JP JP2007508906A patent/JP2007533706A/ja active Pending
- 2005-04-19 EP EP05742781A patent/EP1740188A1/en not_active Ceased
- 2005-04-19 WO PCT/EP2005/051718 patent/WO2005102354A1/en not_active Ceased
- 2005-04-19 CA CA2563556A patent/CA2563556C/en not_active Expired - Fee Related
- 2005-04-19 AU AU2005235384A patent/AU2005235384B2/en not_active Expired
- 2005-04-19 US US11/578,294 patent/US20070134165A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002512193A (ja) * | 1998-04-20 | 2002-04-23 | アストラゼネカ・アクチエボラーグ | 軽度／初期型のｃｏｐｄ（慢性閉塞性肺疾患）を処置することを目的とした薬物の製造のための糖質副腎皮質ステロイドの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20070134165A1 (en) | 2007-06-14 |
| EP1740188A1 (en) | 2007-01-10 |
| AU2005235384A1 (en) | 2005-11-03 |
| CA2563556A1 (en) | 2005-11-03 |
| CA2563556C (en) | 2013-01-29 |
| AU2005235384B2 (en) | 2010-09-09 |
| WO2005102354A1 (en) | 2005-11-03 |
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