JP2007532596A - Ｍｃｈ拮抗効果を有する新規アルキン化合物及び前記化合物を含有する薬物 - Google Patents

Ｍｃｈ拮抗効果を有する新規アルキン化合物及び前記化合物を含有する薬物 Download PDF

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JP2007532596A
JP2007532596A JP2007507709A JP2007507709A JP2007532596A JP 2007532596 A JP2007532596 A JP 2007532596A JP 2007507709 A JP2007507709 A JP 2007507709A JP 2007507709 A JP2007507709 A JP 2007507709A JP 2007532596 A JP2007532596 A JP 2007532596A
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alkyl
phenyl
group
mmol
chloro
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JP2007532596A5 (fr
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ディルク シュテンカンプ
シュテファン ゲオルク ミューラー
フィリップ ルシュテンベルガー
リンツ トルシュテン レーマン
ゲラルト ユールゲン ロート
マルクス シンドラー
レオ トーマス
ラルフ エル ハー ロッツ
クラウス ルドルフ
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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Application filed by ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング filed Critical ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Medicinal Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
JP2007507709A 2004-04-14 2005-04-08 Ｍｃｈ拮抗効果を有する新規アルキン化合物及び前記化合物を含有する薬物 Pending JP2007532596A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004017930A DE102004017930A1 (de) 2004-04-14 2004-04-14 Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
PCT/EP2005/003686 WO2005103032A2 (fr) 2004-04-14 2005-04-08 Nouveaux composes alcyne a effet antagoniste mch, et medicaments contenant ces composes

Publications (2)

Publication Number Publication Date
JP2007532596A true JP2007532596A (ja) 2007-11-15
JP2007532596A5 JP2007532596A5 (fr) 2008-05-29

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ID=34964523

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JP2007507709A Pending JP2007532596A (ja) 2004-04-14 2005-04-08 Ｍｃｈ拮抗効果を有する新規アルキン化合物及び前記化合物を含有する薬物

Country Status (9)

Country Link
EP (1) EP1737824A2 (fr)
JP (1) JP2007532596A (fr)
AR (1) AR048691A1 (fr)
CA (1) CA2558755A1 (fr)
DE (1) DE102004017930A1 (fr)
PE (1) PE20060254A1 (fr)
TW (1) TW200538102A (fr)
UY (1) UY28852A1 (fr)
WO (1) WO2005103032A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007532593A (ja) * 2004-04-14 2007-11-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｍｃｈ拮抗作用を有する新規アルキン化合物及び前記化合物を含有する薬物
JP2021523178A (ja) * 2018-05-11 2021-09-02 ディザル（ジァンスー）ファーマシューティカル・カンパニー・リミテッド シクロペンタン化合物

Families Citing this family (19)

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US7452911B2 (en) 2002-10-31 2008-11-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
EP2049472B1 (fr) 2006-06-23 2015-01-21 AbbVie Bahamas Ltd. Dérivés de cyclopropylamines comme modulateurs du recepteur h3 de l' histamine
NZ575520A (en) 2006-08-25 2012-03-30 Boehringer Ingelheim Int New pyridone derivatives with mch antagonistic activity and medicaments comprising these compounds
EP2102171A1 (fr) 2006-12-11 2009-09-23 Boehringer Ingelheim International GmbH Nouveaux dérivés pyridazines à activité antagoniste du récepteur mch et médicaments comprenant ces composés
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
US20130143869A1 (en) * 2010-07-16 2013-06-06 Merz Pharma Gmbh & Co. Kgaa Use of a cationic amphiphilic drug for the preparation of a formulation for the reduction of subcutaneous adipose tissue
WO2012037258A1 (fr) 2010-09-16 2012-03-22 Abbott Laboratories Procédés de préparation de dérivés cyclopropyliques substitués en 1,2
US8633182B2 (en) 2012-05-30 2014-01-21 Boehringer Ingelheim International Gmbh Indanyloxyphenylcyclopropanecarboxylic acids
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
WO2015091741A1 (fr) 2013-12-19 2015-06-25 Actelion Pharmaceuticals Ltd Dérivés de 1h-indazole et de 1h-indole antibactériens
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
EP3532458B1 (fr) 2016-10-25 2021-01-20 Boehringer Ingelheim International GmbH Acides benzylaminopyridylcyclopropanecarboxyliques, compositions pharmaceutiques et leurs utilisations
JP7008704B2 (ja) 2016-11-28 2022-01-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インダニルアミノピリジルシクロプロパンカルボン酸、その医薬組成物及び使用
WO2018138026A1 (fr) 2017-01-26 2018-08-02 Boehringer Ingelheim International Gmbh Acides indanylaminopyrazinylcyclopropanecarboxyliques, compositions pharmaceutiques et leurs utilisations
EP3573953A1 (fr) 2017-01-26 2019-12-04 Boehringer Ingelheim International GmbH Acides benzyloxypyridylcyclopropanecarboxyliques, compositions pharmaceutiques et leurs utilisations
EP3573952B1 (fr) 2017-01-26 2021-07-14 Boehringer Ingelheim International GmbH Acides benzylaminopyridylcyclopropanecarboxyliques, compositions pharmaceutiques et utilisations associées
US10793530B2 (en) 2017-01-26 2020-10-06 Boehringer Ingelheim International Gmbh Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
CN110312714B (zh) 2017-01-26 2022-12-09 勃林格殷格翰国际有限公司 苄基氧基吡嗪基环丙烷甲酸、其药物组合物和用途

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US5856510A (en) * 1996-12-16 1999-01-05 Allelix Biopharmaceuticals Inc. 5-alkenyl and 5-alkynyl indole compounds
JP2001509504A (ja) * 1997-07-11 2001-07-24 ノバルティス アクチエンゲゼルシャフト ピリジン誘導体
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DE102004017930A1 (de) 2005-11-03
EP1737824A2 (fr) 2007-01-03
UY28852A1 (es) 2005-11-30
TW200538102A (en) 2005-12-01
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