JP2007531594A5 - - Google Patents
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- Publication number
- JP2007531594A5 JP2007531594A5 JP2007506531A JP2007506531A JP2007531594A5 JP 2007531594 A5 JP2007531594 A5 JP 2007531594A5 JP 2007506531 A JP2007506531 A JP 2007506531A JP 2007506531 A JP2007506531 A JP 2007506531A JP 2007531594 A5 JP2007531594 A5 JP 2007531594A5
- Authority
- JP
- Japan
- Prior art keywords
- polyether urethane
- therapeutic agent
- loaded
- implant
- load
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 56
- 229940124597 therapeutic agent Drugs 0.000 claims 45
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 39
- 239000004721 Polyphenylene oxide Substances 0.000 claims 39
- 229920000570 polyether Polymers 0.000 claims 39
- 239000007943 implant Substances 0.000 claims 25
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims 24
- 239000000203 mixture Substances 0.000 claims 18
- 230000009885 systemic effect Effects 0.000 claims 16
- 229920000642 polymer Polymers 0.000 claims 14
- 229940079593 drug Drugs 0.000 claims 11
- 241000124008 Mammalia Species 0.000 claims 6
- 239000011248 coating agent Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000003607 modifier Substances 0.000 claims 6
- -1 polysiloxane Polymers 0.000 claims 6
- 229920002635 polyurethane Polymers 0.000 claims 6
- 239000004814 polyurethane Substances 0.000 claims 6
- 239000000654 additive Substances 0.000 claims 5
- 230000000996 additive effect Effects 0.000 claims 5
- 210000004204 blood vessel Anatomy 0.000 claims 4
- 239000012528 membrane Substances 0.000 claims 4
- 229920001296 polysiloxane Polymers 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- 229930012538 Paclitaxel Natural products 0.000 claims 3
- 229960001592 paclitaxel Drugs 0.000 claims 3
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 3
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 3
- 229960002930 sirolimus Drugs 0.000 claims 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 3
- 239000002473 artificial blood Substances 0.000 claims 2
- 206010020718 hyperplasia Diseases 0.000 claims 2
- 230000003872 anastomosis Effects 0.000 claims 1
- 230000003881 arterial anastomosis Effects 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 229920000139 polyethylene terephthalate Polymers 0.000 claims 1
- 239000005020 polyethylene terephthalate Substances 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 230000003878 venous anastomosis Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/813,315 US20050220835A1 (en) | 2004-03-30 | 2004-03-30 | Agent eluting bioimplantable devices and polymer systems for their preparation |
| PCT/US2005/010835 WO2005094377A2 (en) | 2004-03-30 | 2005-03-30 | Agent eluting bioimplantable devices and polymer systems for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007531594A JP2007531594A (ja) | 2007-11-08 |
| JP2007531594A5 true JP2007531594A5 (enExample) | 2008-08-07 |
Family
ID=35054584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506531A Pending JP2007531594A (ja) | 2004-03-30 | 2005-03-30 | 薬剤を溶出する生体埋め込み型装置及び薬剤調製ポリマーシステム |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20050220835A1 (enExample) |
| EP (1) | EP1750617A4 (enExample) |
| JP (1) | JP2007531594A (enExample) |
| AU (1) | AU2005228688A1 (enExample) |
| CA (1) | CA2561561A1 (enExample) |
| WO (1) | WO2005094377A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7846202B2 (en) | 1995-06-07 | 2010-12-07 | Cook Incorporated | Coated implantable medical device |
| US7867275B2 (en) | 1995-06-07 | 2011-01-11 | Cook Incorporated | Coated implantable medical device method |
| US8388677B2 (en) * | 2004-10-29 | 2013-03-05 | Boston Scientific Scimed, Inc. | Anti-thrombogenic and anti-restenotic vascular medical devices |
| JP5063603B2 (ja) * | 2005-09-30 | 2012-10-31 | クック メディカル テクノロジーズ エルエルシー | 被覆された血管閉塞装置 |
| US9474833B2 (en) | 2006-12-18 | 2016-10-25 | Cook Medical Technologies Llc | Stent graft with releasable therapeutic agent and soluble coating |
| AU2008202283B2 (en) * | 2007-06-01 | 2011-01-20 | Kyong-Min Shin | Coating agent for drug releasing stent, preparation method thereof and drug releasing stent coated therewith |
| US20090171453A1 (en) * | 2007-12-28 | 2009-07-02 | Adams Tara K | Drug Coated Stent Having a Surface Treatment and Method of Manufacturing |
| DE102008002471A1 (de) * | 2008-06-17 | 2009-12-24 | Biotronik Vi Patent Ag | Stent mit einer Beschichtung oder einem Grundkörper, der ein Lithiumsalz enthält, und Verwendung von Lithiumsalzen zur Restenoseprophylaxe |
| KR101034654B1 (ko) * | 2009-01-15 | 2011-05-16 | 성균관대학교산학협력단 | 바이오액티브 물질 코팅방법 |
| US8715705B2 (en) * | 2009-07-29 | 2014-05-06 | Covidien Lp | Multilayer medical devices having an encapsulated edge and methods thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US107330A (en) * | 1870-09-13 | Improvement in car-starters | ||
| US187288A (en) * | 1877-02-13 | Improvement in ratchet-wrenches | ||
| US4374669A (en) * | 1975-05-09 | 1983-02-22 | Mac Gregor David C | Cardiovascular prosthetic devices and implants with porous systems |
| US4861830A (en) * | 1980-02-29 | 1989-08-29 | Th. Goldschmidt Ag | Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming |
| CA1206668A (en) * | 1980-02-29 | 1986-06-24 | Robert S. Ward, Jr. | Polymer surfaces for blood-contacting surfaces of a biomedical device, and methods for forming |
| US4675361A (en) * | 1980-02-29 | 1987-06-23 | Thoratec Laboratories Corp. | Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming |
| US4604762A (en) * | 1981-02-13 | 1986-08-12 | Thoratec Laboratories Corporation | Arterial graft prosthesis |
| US4910015A (en) * | 1987-10-19 | 1990-03-20 | Massachusetts Institute Of Technology | Surface-active polysiloxanes and drug releasing materials thereof |
| WO1989005660A1 (fr) * | 1987-12-23 | 1989-06-29 | Poltavsky Meditsinsky Stomatologichesky Institut | Preparation pharmaceutique pour la prophylaxie individuelle des maladies veneriennes et pour traiter la trichomonase urogenitale |
| US4840796A (en) | 1988-04-22 | 1989-06-20 | Dow Corning Corporation | Block copolymer matrix for transdermal drug release |
| US6515009B1 (en) * | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| AU649885B2 (en) * | 1991-10-01 | 1994-06-02 | Nisshinbo Industries, Inc. | Antithrombotic resin, tube, film and coating |
| PH30923A (en) * | 1992-03-30 | 1997-12-23 | American Home Prod | Rapamycin formulation for iv injection. |
| GB9215002D0 (en) * | 1992-07-15 | 1992-08-26 | Univ Singapore | Method of fixing biological tissue |
| PT711158E (pt) * | 1993-07-29 | 2004-04-30 | Us Gov Health & Human Serv | Metodo para tratar aterosclerose ou restenose utilizando um agente de estabilizacao dos microtubulos |
| US5723004A (en) * | 1993-10-21 | 1998-03-03 | Corvita Corporation | Expandable supportive endoluminal grafts |
| US5482925A (en) * | 1994-03-17 | 1996-01-09 | Comedicus Incorporated | Complexes of nitric oxide with cardiovascular amines as dual acting cardiovascular agents |
| US5609629A (en) * | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
| US5877205A (en) * | 1996-06-28 | 1999-03-02 | Board Of Regents, The University Of Texas System | Parenteral paclitaxel in a stable non-toxic formulation |
| US5962620A (en) | 1996-08-26 | 1999-10-05 | Tyndale Plains-Hunter, Ltd. | Hydrophicic and hydrophobic polyether polyurethanes and uses therefor |
| US6273913B1 (en) * | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
| US6335029B1 (en) * | 1998-08-28 | 2002-01-01 | Scimed Life Systems, Inc. | Polymeric coatings for controlled delivery of active agents |
| WO2000048530A1 (en) * | 1999-02-16 | 2000-08-24 | Talison Research, Inc. | Multilayer and multifunction vascular graft |
| US6387116B1 (en) * | 1999-06-30 | 2002-05-14 | Pharmasonics, Inc. | Methods and kits for the inhibition of hyperplasia in vascular fistulas and grafts |
| WO2001021163A2 (en) * | 1999-09-21 | 2001-03-29 | Emory University | Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents |
| US6776796B2 (en) * | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
| AU2001285059A1 (en) * | 2000-08-23 | 2002-03-04 | Thoratec Corporation | Coated vascular grafts and methods of use |
| US6545097B2 (en) | 2000-12-12 | 2003-04-08 | Scimed Life Systems, Inc. | Drug delivery compositions and medical devices containing block copolymer |
| US6592885B2 (en) * | 2001-06-07 | 2003-07-15 | Matthew D. Phaneuf | Method for making infection-resistant fabricated textile articles for biomedical applications |
| US20020187288A1 (en) * | 2001-06-11 | 2002-12-12 | Advanced Cardiovascular Systems, Inc. | Medical device formed of silicone-polyurethane |
| US6752826B2 (en) * | 2001-12-14 | 2004-06-22 | Thoratec Corporation | Layered stent-graft and methods of making the same |
| US20060204537A1 (en) | 2002-06-21 | 2006-09-14 | Genzyme Corporation | Silicone blends and composites for drug delivery |
| JP2005538756A (ja) * | 2002-07-18 | 2005-12-22 | メドトロニック・エイヴイイー・インコーポレーテッド | 再狭窄を阻害するためのタンパク質−チロシンキナーゼ阻害物質を含んでなる医療デバイス |
| US20040213826A1 (en) * | 2003-04-28 | 2004-10-28 | Marx Steven O. | Medical devices and methods for inhibiting proliferation of smooth muscle cells |
-
2004
- 2004-03-30 US US10/813,315 patent/US20050220835A1/en not_active Abandoned
-
2005
- 2005-03-30 JP JP2007506531A patent/JP2007531594A/ja active Pending
- 2005-03-30 WO PCT/US2005/010835 patent/WO2005094377A2/en not_active Ceased
- 2005-03-30 AU AU2005228688A patent/AU2005228688A1/en not_active Abandoned
- 2005-03-30 CA CA002561561A patent/CA2561561A1/en not_active Abandoned
- 2005-03-30 EP EP05761380A patent/EP1750617A4/en not_active Withdrawn
-
2008
- 2008-11-14 US US12/270,995 patent/US20090130170A1/en not_active Abandoned
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