JP2007530450A5 - - Google Patents
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- JP2007530450A5 JP2007530450A5 JP2006547424A JP2006547424A JP2007530450A5 JP 2007530450 A5 JP2007530450 A5 JP 2007530450A5 JP 2006547424 A JP2006547424 A JP 2006547424A JP 2006547424 A JP2006547424 A JP 2006547424A JP 2007530450 A5 JP2007530450 A5 JP 2007530450A5
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- JP
- Japan
- Prior art keywords
- group
- alkyl
- alkenyl
- aryl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 34
- 150000003839 salts Chemical class 0.000 claims description 19
- 239000011780 sodium chloride Substances 0.000 claims description 19
- 150000001875 compounds Chemical class 0.000 claims description 15
- 125000004450 alkenylene group Chemical group 0.000 claims description 10
- 125000000732 arylene group Chemical group 0.000 claims description 10
- 125000005549 heteroarylene group Chemical group 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims 75
- 125000003342 alkenyl group Chemical group 0.000 claims 41
- 125000000623 heterocyclic group Chemical group 0.000 claims 40
- 125000003118 aryl group Chemical group 0.000 claims 38
- 125000000304 alkynyl group Chemical group 0.000 claims 30
- 125000002947 alkylene group Chemical group 0.000 claims 28
- 229910052739 hydrogen Inorganic materials 0.000 claims 27
- 239000001257 hydrogen Substances 0.000 claims 27
- -1 heteroarylalkylenyl Chemical group 0.000 claims 26
- 125000004432 carbon atoms Chemical group C* 0.000 claims 20
- 125000004663 dialkyl amino group Chemical group 0.000 claims 20
- 125000003545 alkoxy group Chemical group 0.000 claims 19
- 229910052799 carbon Inorganic materials 0.000 claims 19
- 229910052736 halogen Inorganic materials 0.000 claims 19
- 150000002367 halogens Chemical class 0.000 claims 19
- 150000002431 hydrogen Chemical class 0.000 claims 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 17
- 125000005842 heteroatoms Chemical group 0.000 claims 16
- 125000001188 haloalkyl group Chemical group 0.000 claims 15
- 125000004104 aryloxy group Chemical group 0.000 claims 14
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 14
- 125000004414 alkyl thio group Chemical group 0.000 claims 13
- 125000005466 alkylenyl group Chemical group 0.000 claims 12
- 125000003282 alkyl amino group Chemical group 0.000 claims 10
- 125000005529 alkyleneoxy group Chemical group 0.000 claims 10
- 125000005532 aryl alkyleneoxy group Chemical group 0.000 claims 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims 10
- 125000004438 haloalkoxy group Chemical group 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 10
- 125000004043 oxo group Chemical group O=* 0.000 claims 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 125000004419 alkynylene group Chemical group 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 6
- 125000004423 acyloxy group Chemical group 0.000 claims 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 6
- 125000005110 aryl thio group Chemical group 0.000 claims 6
- 125000001589 carboacyl group Chemical group 0.000 claims 6
- KLGZELKXQMTEMM-UHFFFAOYSA-N hydride Chemical compound [H-] KLGZELKXQMTEMM-UHFFFAOYSA-N 0.000 claims 6
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 6
- 125000002877 alkyl aryl group Chemical group 0.000 claims 4
- 125000001145 hydrido group Chemical group *[H] 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000005977 Ethylene Substances 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 230000037348 biosynthesis Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 10
- 125000005418 aryl aryl group Chemical group 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- ITIRVXDSMXFTPW-UHFFFAOYSA-N 1H-imidazo[4,5-c]quinoline Chemical class C1=CC=CC2=C(NC=N3)C3=CN=C21 ITIRVXDSMXFTPW-UHFFFAOYSA-N 0.000 description 1
- IRNQWWPSQJKGCD-UHFFFAOYSA-N 2,3,3a,4-tetrahydro-1H-imidazo[4,5-c][1,5]naphthyridin-6-amine Chemical compound C1N=C2C(N)=CC=NC2=C2NCNC21 IRNQWWPSQJKGCD-UHFFFAOYSA-N 0.000 description 1
- YHEPBWTXCZVUHG-UHFFFAOYSA-N 3H-imidazo[4,5-c]quinolin-6-amine Chemical compound N1=C2C(N)=CC=CC2=C2NC=NC2=C1 YHEPBWTXCZVUHG-UHFFFAOYSA-N 0.000 description 1
- RHKWIGHJGOEUSM-UHFFFAOYSA-N 3H-imidazo[4,5-h]quinoline Chemical compound C1=CN=C2C(N=CN3)=C3C=CC2=C1 RHKWIGHJGOEUSM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 125000002346 iodo group Chemical group I* 0.000 description 1
- UTOMICFLROGMAE-UHFFFAOYSA-N quinoline-3,4-diamine Chemical compound C1=CC=CC2=C(N)C(N)=CN=C21 UTOMICFLROGMAE-UHFFFAOYSA-N 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53302403P | 2003-12-29 | 2003-12-29 | |
| PCT/US2004/043474 WO2005066172A1 (en) | 2003-12-29 | 2004-12-22 | Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007530450A JP2007530450A (ja) | 2007-11-01 |
| JP2007530450A5 true JP2007530450A5 (US07794700-20100914-C00152.png) | 2008-02-07 |
Family
ID=34748841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547424A Pending JP2007530450A (ja) | 2003-12-29 | 2004-12-22 | ピペラジン、［１，４］ジアゼパン、［１，４］ジアゾカン、および［１，５］ジアゾカン縮合イミダゾ環化合物 |
Country Status (7)
Families Citing this family (61)
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| US20040265351A1 (en) | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| BRPI0412902A (pt) | 2003-08-12 | 2006-09-26 | 3M Innovative Properties Co | compostos contendo imidazo substituìdo por oxima |
| ES2406730T3 (es) * | 2003-08-27 | 2013-06-07 | 3M Innovative Properties Company | Imidazoquinolinas sustituidas con ariloxi y arilalquilenoxi |
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| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| JP2007508305A (ja) | 2003-10-03 | 2007-04-05 | スリーエム イノベイティブ プロパティズ カンパニー | ピラゾロピリジンおよびその類似物 |
| RU2412942C2 (ru) | 2003-10-03 | 2011-02-27 | 3М Инновейтив Пропертиз Компани | Оксизамещенные имидазохинолины, способные модулировать биосинтез цитокинов |
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| JP2008526765A (ja) | 2004-12-30 | 2008-07-24 | スリーエム イノベイティブ プロパティズ カンパニー | 皮膚転移の処置 |
| US9248127B2 (en) | 2005-02-04 | 2016-02-02 | 3M Innovative Properties Company | Aqueous gel formulations containing immune response modifiers |
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| CA2597446A1 (en) * | 2005-02-11 | 2006-08-31 | Coley Pharmaceutical Group, Inc. | Substituted imidazoquinolines and imidazonaphthyridines |
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| HUE051988T2 (hu) | 2013-01-07 | 2021-04-28 | Univ Pennsylvania | Készítmények és eljárások bõr T-sejt lymphoma kezelésére |
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| US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
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| US10526309B2 (en) | 2015-10-02 | 2020-01-07 | The University Of North Carolina At Chapel Hill | Pan-TAM inhibitors and Mer/Axl dual inhibitors |
| EP3504215B1 (en) | 2016-08-26 | 2022-04-06 | 3M Innovative Properties Company | Fused [1,2]imidazo[4,5-c]ring compounds substituted with guanidino groups |
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2004
- 2004-12-22 AU AU2004312510A patent/AU2004312510A1/en not_active Abandoned
- 2004-12-22 CN CNA2004800422008A patent/CN1922178A/zh active Pending
- 2004-12-22 WO PCT/US2004/043474 patent/WO2005066172A1/en not_active Application Discontinuation
- 2004-12-22 CA CA002552101A patent/CA2552101A1/en not_active Abandoned
- 2004-12-22 US US10/596,895 patent/US7888349B2/en not_active Expired - Fee Related
- 2004-12-22 JP JP2006547424A patent/JP2007530450A/ja active Pending
- 2004-12-22 EP EP04815538A patent/EP1699792A1/en not_active Withdrawn
