JP2007527241A5 - - Google Patents
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- Publication number
- JP2007527241A5 JP2007527241A5 JP2007501893A JP2007501893A JP2007527241A5 JP 2007527241 A5 JP2007527241 A5 JP 2007527241A5 JP 2007501893 A JP2007501893 A JP 2007501893A JP 2007501893 A JP2007501893 A JP 2007501893A JP 2007527241 A5 JP2007527241 A5 JP 2007527241A5
- Authority
- JP
- Japan
- Prior art keywords
- egfr
- indicator
- therapeutic agent
- patient
- assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 5
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 5
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 5
- 238000003556 assay Methods 0.000 claims 4
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 108700028369 Alleles Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 108700021358 erbB-1 Genes Proteins 0.000 claims 2
- 230000001988 toxicity Effects 0.000 claims 2
- 231100000419 toxicity Toxicity 0.000 claims 2
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 230000008482 dysregulation Effects 0.000 claims 1
- 229940121647 egfr inhibitor Drugs 0.000 claims 1
- 229960001433 erlotinib Drugs 0.000 claims 1
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 1
- 229960002584 gefitinib Drugs 0.000 claims 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 210000005087 mononuclear cell Anatomy 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000010837 poor prognosis Methods 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54906904P | 2004-03-01 | 2004-03-01 | |
| PCT/US2005/006559 WO2005085473A2 (en) | 2004-03-01 | 2005-03-01 | Polymorphisms in the epidermal growth factor receptor gene promoter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007527241A JP2007527241A (ja) | 2007-09-27 |
| JP2007527241A5 true JP2007527241A5 (enExample) | 2008-04-17 |
Family
ID=34919431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501893A Pending JP2007527241A (ja) | 2004-03-01 | 2005-03-01 | 上皮細胞成長因子受容体遺伝子プロモーターにおける多型 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070275386A1 (enExample) |
| EP (1) | EP1730306A2 (enExample) |
| JP (1) | JP2007527241A (enExample) |
| KR (1) | KR20070048645A (enExample) |
| CN (1) | CN101056990A (enExample) |
| CA (1) | CA2558753A1 (enExample) |
| WO (1) | WO2005085473A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007039705A1 (en) * | 2005-10-05 | 2007-04-12 | Astrazeneca Uk Limited | Method to predict or monitor the response of a patient to an erbb receptor drug |
| EP3216874A1 (en) | 2008-09-05 | 2017-09-13 | TOMA Biosciences, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| US9416409B2 (en) | 2009-07-31 | 2016-08-16 | Ibis Biosciences, Inc. | Capture primers and capture sequence linked solid supports for molecular diagnostic tests |
| EP3153592A1 (en) * | 2009-08-04 | 2017-04-12 | F. Hoffmann-La Roche AG | Responsiveness to angiogenesis inhibitors |
| CN102134275B (zh) * | 2010-01-26 | 2013-12-04 | 上海市肿瘤研究所 | 表皮生长因子受体变异体 |
| EP3572528A1 (en) | 2010-09-24 | 2019-11-27 | The Board of Trustees of the Leland Stanford Junior University | Direct capture, amplification and sequencing of target dna using immobilized primers |
| EP2554551A1 (en) | 2011-08-03 | 2013-02-06 | Fundacio Institut mar d'Investigacions Médiques (IMIM) | Mutations in the epidermal growth factor receptor gene |
| CN103045746A (zh) * | 2012-12-31 | 2013-04-17 | 上海市胸科医院 | Egfr基因突变检测的扩增引物、检测探针和液相芯片 |
| US9873908B2 (en) * | 2013-11-27 | 2018-01-23 | Roche Molecular Systems, Inc. | Methods for the enrichment of mutated nucleic acid from a mixture |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5786344A (en) * | 1994-07-05 | 1998-07-28 | Arch Development Corporation | Camptothecin drug combinations and methods with reduced side effects |
| US6395481B1 (en) * | 1999-02-16 | 2002-05-28 | Arch Development Corp. | Methods for detection of promoter polymorphism in a UGT gene promoter |
| WO2001080896A2 (en) * | 2000-04-21 | 2001-11-01 | Arch Development Corporation | Flavopiridol drug combinations and methods with reduced side effects |
| AU2002240066A1 (en) * | 2001-01-26 | 2002-08-06 | University Of Chicago | Determination of ugt2b7 gene polymorphisms for predicting ugt2b7 substrate toxicity and for optimising drug dosage |
| AU2003257110A1 (en) * | 2002-07-31 | 2004-02-16 | University Of Southern California | Polymorphisms for predicting disease and treatment outcome |
| US20040203034A1 (en) * | 2003-01-03 | 2004-10-14 | The University Of Chicago | Optimization of cancer treatment with irinotecan |
-
2005
- 2005-03-01 KR KR1020067020515A patent/KR20070048645A/ko not_active Withdrawn
- 2005-03-01 CN CNA2005800064657A patent/CN101056990A/zh active Pending
- 2005-03-01 EP EP05724156A patent/EP1730306A2/en not_active Withdrawn
- 2005-03-01 JP JP2007501893A patent/JP2007527241A/ja active Pending
- 2005-03-01 WO PCT/US2005/006559 patent/WO2005085473A2/en not_active Ceased
- 2005-03-01 CA CA002558753A patent/CA2558753A1/en not_active Abandoned
- 2005-03-01 US US10/591,228 patent/US20070275386A1/en not_active Abandoned
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