JP2007523162A5 - - Google Patents
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- Publication number
- JP2007523162A5 JP2007523162A5 JP2006554085A JP2006554085A JP2007523162A5 JP 2007523162 A5 JP2007523162 A5 JP 2007523162A5 JP 2006554085 A JP2006554085 A JP 2006554085A JP 2006554085 A JP2006554085 A JP 2006554085A JP 2007523162 A5 JP2007523162 A5 JP 2007523162A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- dihydroxyvitamin
- methylene
- osteoporosis
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 239000011612 calcitriol Substances 0.000 claims 10
- 208000001132 Osteoporosis Diseases 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000037118 bone strength Effects 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 206010039984 Senile osteoporosis Diseases 0.000 claims 2
- 230000008416 bone turnover Effects 0.000 claims 2
- 208000005368 osteomalacia Diseases 0.000 claims 2
- 208000001685 postmenopausal osteoporosis Diseases 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 230000001054 cortical effect Effects 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 0 C[C@@](CCCC(C)(C)O)C(CC1)[C@]2(C)C1C(CC=C(C[C@](C1=C)O)C[C@]1O*)CCC2 Chemical compound C[C@@](CCCC(C)(C)O)C(CC1)[C@]2(C)C1C(CC=C(C[C@](C1=C)O)C[C@]1O*)CCC2 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/782,337 US7214671B2 (en) | 2004-02-19 | 2004-02-19 | Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases |
| PCT/US2004/042657 WO2005082456A1 (en) | 2004-02-19 | 2004-12-17 | USE OF 2-METHYLENE-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 FOR THE PROPHYLAXIS OF BONE DISEASES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007523162A JP2007523162A (ja) | 2007-08-16 |
| JP2007523162A5 true JP2007523162A5 (https=) | 2008-02-07 |
Family
ID=34861010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006554085A Pending JP2007523162A (ja) | 2004-02-19 | 2004-12-17 | ２‐メチレン‐１９‐ノル‐２０（Ｓ）‐１α，２５‐ジヒドロキシビタミンＤ３の骨疾患の予防のための使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7214671B2 (https=) |
| EP (1) | EP1722856B1 (https=) |
| JP (1) | JP2007523162A (https=) |
| AU (1) | AU2004316404B2 (https=) |
| CA (1) | CA2556931C (https=) |
| ES (1) | ES2399328T3 (https=) |
| NZ (1) | NZ549318A (https=) |
| WO (1) | WO2005082456A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006061683A1 (en) * | 2004-12-09 | 2006-06-15 | Pfizer Products Inc. | 2-alkylidene-19-nor-vitamin d derivatives for the treatment of osteogenesis imperfecta |
| EP2021321B1 (en) * | 2006-04-06 | 2012-06-20 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin d3 and uses thereof |
| MX2008012912A (es) * | 2006-04-06 | 2008-11-26 | Wisconsin Alumni Res Found | Analogos de 2-metilen-1a,25-dihidroxi-19,21-dinorvitamina d3 y sus usos. |
| AU2010281391B2 (en) * | 2009-08-03 | 2015-05-07 | Wisconsin Alumni Research Foundation | Method of preventing renal disease and treating symptoms thereof |
| CA2793727C (en) * | 2010-03-23 | 2017-01-03 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1.alpha.,25-dihydroxyvitamin d3 |
| US8604009B2 (en) * | 2010-03-23 | 2013-12-10 | Wisconsin Alumni Research Foundation | (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22-dimethyl-1α,25-hydroxyvitamin D3 |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| CN104394871A (zh) | 2012-06-29 | 2015-03-04 | 威斯康星旧生研究基金会 | 2-亚甲基-19-去甲-(20S)-1α,25-二羟基维生素D3治疗继发性甲状旁腺功能亢进的用途 |
| US9539264B2 (en) | 2014-12-30 | 2017-01-10 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism in patients previously treated with calcimimetics |
| US10369161B2 (en) | 2014-12-30 | 2019-08-06 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism |
| CN119632967B (zh) * | 2024-11-14 | 2025-10-21 | 广州健尔圣医药科技有限公司 | 二硫代氨基甲酸类化合物在制备预防和/或治疗骨质疏松药物中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3626058A1 (de) * | 1986-08-01 | 1988-02-11 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US6316642B1 (en) * | 1997-03-17 | 2001-11-13 | Wisconsin Alumni Research Foundation | 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds |
| US6306844B1 (en) * | 1997-03-17 | 2001-10-23 | Wisconsin Alumni Research Foundation | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
| US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| GB9709082D0 (en) * | 1997-05-06 | 1997-06-25 | Ciba Geigy Ag | Organic compositions |
| US6313119B1 (en) * | 1998-01-23 | 2001-11-06 | Adventis Pharma Deutschland Gmbh | Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion |
| US6114317A (en) * | 1998-05-21 | 2000-09-05 | Wisconsin Alumni Research Foundation | Method of locking 1α-OH of vitamin D compounds in axial orientation |
| US5972917A (en) * | 1998-05-29 | 1999-10-26 | Bone Care Int Inc | 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof |
| MXPA03000406A (es) * | 2000-07-14 | 2003-06-06 | Wisconsin Alumni Res Found | Uso de 2-metilen-19-nor-20(s)-1 alfa,25-dihidroxivitamina d3 para incrementar la resistencia de los huesos. |
| NZ524657A (en) * | 2000-09-08 | 2004-12-24 | Wisconsin Alumni Res Found | 1 alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
| US6566352B1 (en) * | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| US20030195175A1 (en) * | 2002-03-25 | 2003-10-16 | Deluca Hector F. | Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone |
-
2004
- 2004-02-19 US US10/782,337 patent/US7214671B2/en not_active Expired - Lifetime
- 2004-12-17 EP EP04814798A patent/EP1722856B1/en not_active Expired - Lifetime
- 2004-12-17 AU AU2004316404A patent/AU2004316404B2/en not_active Ceased
- 2004-12-17 JP JP2006554085A patent/JP2007523162A/ja active Pending
- 2004-12-17 WO PCT/US2004/042657 patent/WO2005082456A1/en not_active Ceased
- 2004-12-17 CA CA2556931A patent/CA2556931C/en not_active Expired - Fee Related
- 2004-12-17 NZ NZ549318A patent/NZ549318A/en not_active IP Right Cessation
- 2004-12-17 ES ES04814798T patent/ES2399328T3/es not_active Expired - Lifetime
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