JP2007517498A5 - - Google Patents
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- Publication number
- JP2007517498A5 JP2007517498A5 JP2006531018A JP2006531018A JP2007517498A5 JP 2007517498 A5 JP2007517498 A5 JP 2007517498A5 JP 2006531018 A JP2006531018 A JP 2006531018A JP 2006531018 A JP2006531018 A JP 2006531018A JP 2007517498 A5 JP2007517498 A5 JP 2007517498A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- use according
- bmp2a
- nos
- nucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 4
- 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 claims 4
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- 108020004459 Small interfering RNA Proteins 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 239000000074 antisense oligonucleotide Substances 0.000 claims 2
- 238000012230 antisense oligonucleotides Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50927903P | 2003-10-07 | 2003-10-07 | |
| PCT/IL2004/000924 WO2005041857A2 (en) | 2003-10-07 | 2004-10-06 | Bone morphogenetic protein (bmp) 2a and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007517498A JP2007517498A (ja) | 2007-07-05 |
| JP2007517498A5 true JP2007517498A5 (https=) | 2007-11-22 |
Family
ID=34549195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006531018A Withdrawn JP2007517498A (ja) | 2003-10-07 | 2004-10-06 | 骨形態形成タンパク質（ｂｍｐ）２ａ及びその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20080249038A1 (https=) |
| EP (1) | EP1670425A4 (https=) |
| JP (1) | JP2007517498A (https=) |
| CA (1) | CA2541852A1 (https=) |
| WO (1) | WO2005041857A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009002418A (es) * | 2006-09-05 | 2009-04-23 | Medarex Inc | Anticuerpos para las proteinas morfogenicas oseas y receptores de estas y metodos para su uso. |
| JP2010507387A (ja) | 2006-10-25 | 2010-03-11 | クアーク・ファーマスーティカルス、インコーポレイテッド | 新規のｓｉＲＮＡおよびその使用方法 |
| JP2010539932A (ja) * | 2007-09-28 | 2010-12-24 | ストライカー コーポレイション | 骨形成タンパク質に対する中和抗体を検出するための方法 |
| AU2008306455C1 (en) | 2007-10-03 | 2014-04-17 | Quark Pharmaceuticals, Inc. | Novel siRNA structures |
| EP2861620A2 (en) * | 2012-06-14 | 2015-04-22 | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | Use of blocking agents of bone morphogenie protein (bmp) signaling for the treatment of neuroinflammatory and neurodegenerative diseases |
| CN106282241A (zh) * | 2016-08-05 | 2017-01-04 | 无锡市第二人民医院 | 通过CRISPR/Cas9得到敲除bmp2a基因的斑马鱼的方法 |
| WO2018115879A1 (en) | 2016-12-21 | 2018-06-28 | Mereo Biopharma 3 Limited | Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta |
| IL251949A0 (en) | 2017-04-26 | 2017-07-31 | Medical Res Infrastructure & Health Services Fund Tel Aviv Medical Ct | Small organic molecules for use in the treatment of neuro-inflammatory diseases |
| CN118001293B (zh) * | 2023-12-12 | 2025-02-18 | 中国科学技术大学 | 一种治疗衰老相关认知功能障碍的药物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5168050A (en) * | 1990-05-24 | 1992-12-01 | Genentech, Inc. | Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion |
| DK0716610T3 (da) * | 1993-08-26 | 2006-09-04 | Genetics Inst Llc | Humane knogle-morfogenetiske proteiner til anvendelse ved neural regenerering |
| EP0890639A3 (en) * | 1997-07-09 | 2001-10-10 | Gesellschaft für biotechnologische Forschung mbH (GBF) | BMP2-induced cDNA and its use |
| JP2002525081A (ja) * | 1998-08-27 | 2002-08-13 | クォーク・バイオテク・インコーポレーテッド | 低酸素により調節される遺伝子転写に特徴的な配列 |
| WO2002081628A2 (en) * | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
| US20040259247A1 (en) * | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US20040115201A1 (en) * | 2002-09-25 | 2004-06-17 | Paz Einat | Mitotic kinesin-like protein-1, MKLP1, and uses thereof |
-
2004
- 2004-10-06 US US10/575,121 patent/US20080249038A1/en not_active Abandoned
- 2004-10-06 JP JP2006531018A patent/JP2007517498A/ja not_active Withdrawn
- 2004-10-06 EP EP04770595A patent/EP1670425A4/en not_active Withdrawn
- 2004-10-06 WO PCT/IL2004/000924 patent/WO2005041857A2/en not_active Ceased
- 2004-10-06 CA CA002541852A patent/CA2541852A1/en not_active Abandoned
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