JP2007510401A - 高度に多型の標的配列の一塩基多型分析 - Google Patents
高度に多型の標的配列の一塩基多型分析 Download PDFInfo
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- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 238000005382 thermal cycling Methods 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
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- 239000013638 trimer Substances 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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| JP2007224028A (ja) * | 2006-02-20 | 2007-09-06 | F Hoffmann La Roche Ag | 改善された標識試薬 |
| JP2016531122A (ja) * | 2013-08-08 | 2016-10-06 | ザ スクリップス リサーチ インスティテュートＴｈｅ Ｓｃｒｉｐｐｓ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ | 非天然ヌクレオチドの取り込みによるインビトロの核酸の部位特異的な酵素標識のための方法 |
| JP2016533171A (ja) * | 2013-10-01 | 2016-10-27 | エピスタム リミテッド | 融解温度およびユニバーサル塩基を用いた変異解析 |
| US10610571B2 (en) | 2017-08-03 | 2020-04-07 | Synthorx, Inc. | Cytokine conjugates for the treatment of proliferative and infectious diseases |
| US11077195B2 (en) | 2019-02-06 | 2021-08-03 | Synthorx, Inc. | IL-2 conjugates and methods of use thereof |
| JP2023503074A (ja) * | 2019-11-19 | 2023-01-26 | エスエフシー カンパニー リミテッド | 消光子およびこの用途 |
| JP7276571B1 (ja) | 2022-06-20 | 2023-05-18 | 凸版印刷株式会社 | フラップエンドヌクレアーゼの蛍光基質における三重鎖構造の形成効率を向上させる方法 |
| US11834689B2 (en) | 2017-07-11 | 2023-12-05 | The Scripps Research Institute | Incorporation of unnatural nucleotides and methods thereof |
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| WO2007106690A2 (en) | 2006-03-15 | 2007-09-20 | Siemens Healthcare Diagnostics Inc. | Degenerate nucleobase analogs |
| US20100129317A1 (en) * | 2006-09-11 | 2010-05-27 | Southern Research Institute | Azole nucleosides and use as inhibitors of rna and dna viral polymerases |
| WO2009055039A1 (en) * | 2007-10-25 | 2009-04-30 | Canon U.S. Life Sciences, Inc | High-resolution melting analysis |
| US9534255B2 (en) | 2008-12-17 | 2017-01-03 | Life Technologies Corporation | Methods, compositions, and kits for detecting allelic variants |
| EP3249053A1 (en) | 2009-03-27 | 2017-11-29 | Life Technologies Corporation | Methods, compositions, and kits for detecting allelic variants |
| EP2414361A1 (en) | 2009-03-31 | 2012-02-08 | ArQule, Inc. | Substituted heterocyclic compounds |
| CN101659952B (zh) * | 2009-07-14 | 2012-07-18 | 上海之江生物科技有限公司 | 锁核酸和小沟结合物共修饰核酸片段 |
| ES2574625T3 (es) * | 2009-11-25 | 2016-06-21 | Elitechgroup B.V. | Antagonistas de miARN de oligonucleótido conjugado con aglutinante del surco menor (MGB) |
| US20120214160A1 (en) * | 2011-01-14 | 2012-08-23 | Life Technologies Corporation | Methods, compositions, and kits for detecting rare cells |
| US8969003B2 (en) | 2011-03-23 | 2015-03-03 | Elitech Holding B.V. | Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use |
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| JP2013081448A (ja) * | 2011-05-02 | 2013-05-09 | Arkray Inc | 遺伝子変異検出用プローブ |
| EP2714939B1 (en) | 2011-05-24 | 2015-04-15 | Elitech Holding B.V. | Detection of methicillin-resistant staphylococcus aureus |
| WO2014160046A1 (en) * | 2013-03-14 | 2014-10-02 | The Trustees Of The University Of Pennsylvania | A method for detecting mutations in single cells or single molecules |
| WO2014159063A1 (en) | 2013-03-14 | 2014-10-02 | Elitech Holding B.V. | Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use |
| ES2654631T3 (es) | 2013-05-13 | 2018-02-14 | Elitechgroup B.V. | PCR digital en gotas con sondas cortas de ranura menor |
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| EP3230468B1 (en) | 2014-12-12 | 2020-09-16 | ELITechGroup, Inc. | Methods and kits for detecting antibiotic resistant bacteria |
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| US10677728B2 (en) | 2017-08-17 | 2020-06-09 | Elitechgroup B.V. | Duplex stabilizing fluorescence quenchers for nucleic acid probes |
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- 2004-09-30 JP JP2006534123A patent/JP2007510401A/ja active Pending
- 2004-09-30 CA CA002540551A patent/CA2540551A1/en not_active Abandoned
- 2004-09-30 WO PCT/US2004/032265 patent/WO2005035545A2/en not_active Ceased
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2007224028A (ja) * | 2006-02-20 | 2007-09-06 | F Hoffmann La Roche Ag | 改善された標識試薬 |
| JP2016531122A (ja) * | 2013-08-08 | 2016-10-06 | ザ スクリップス リサーチ インスティテュートＴｈｅ Ｓｃｒｉｐｐｓ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ | 非天然ヌクレオチドの取り込みによるインビトロの核酸の部位特異的な酵素標識のための方法 |
| JP2019196355A (ja) * | 2013-08-08 | 2019-11-14 | ザ スクリップス リサーチ インスティテュートＴｈｅ Ｓｃｒｉｐｐｓｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ | 非天然ヌクレオチドの取り込みによるインビトロの核酸の部位特異的な酵素標識のための方法 |
| US10626138B2 (en) | 2013-08-08 | 2020-04-21 | The Scripps Research Institute National Institutes Of Health (Nih), U.S. Dept Of Health And Human Services (Dhhs) | Method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides |
| US12281137B2 (en) | 2013-08-08 | 2025-04-22 | The Scripps Research Institute | Method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides |
| JP7813751B2 (ja) | 2013-08-08 | 2026-02-13 | ザ スクリップス リサーチ インスティテュート | 非天然ヌクレオチドの取り込みによるインビトロの核酸の部位特異的な酵素標識のための方法 |
| US11634451B2 (en) | 2013-08-08 | 2023-04-25 | The Scripps Research Institute | Method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides |
| JP2023179406A (ja) * | 2013-08-08 | 2023-12-19 | ザ スクリップス リサーチ インスティテュート | 非天然ヌクレオチドの取り込みによるインビトロの核酸の部位特異的な酵素標識のための方法 |
| JP2016533171A (ja) * | 2013-10-01 | 2016-10-27 | エピスタム リミテッド | 融解温度およびユニバーサル塩基を用いた変異解析 |
| US11834689B2 (en) | 2017-07-11 | 2023-12-05 | The Scripps Research Institute | Incorporation of unnatural nucleotides and methods thereof |
| US12319944B2 (en) | 2017-07-11 | 2025-06-03 | The Scripps Research Institute | Incorporation of unnatural nucleotides and methods thereof |
| US10610571B2 (en) | 2017-08-03 | 2020-04-07 | Synthorx, Inc. | Cytokine conjugates for the treatment of proliferative and infectious diseases |
| US11701407B2 (en) | 2017-08-03 | 2023-07-18 | Synthorx, Inc. | Cytokine conjugates for the treatment of proliferative and infectious diseases |
| US12377131B2 (en) | 2017-08-03 | 2025-08-05 | Synthorx, Inc. | Cytokine conjugates for the treatment of autoimmune diseases |
| US11622993B2 (en) | 2017-08-03 | 2023-04-11 | Synthorx, Inc. | Cytokine conjugates for the treatment of autoimmune diseases |
| US12318431B2 (en) | 2017-08-03 | 2025-06-03 | Synthorx, Inc. | Cytokine conjugates for the treatment of proliferative and infectious diseases |
| US12521437B2 (en) | 2019-02-06 | 2026-01-13 | Synthorx, Inc. | IL-2 conjugates and methods of use thereof |
| US11077195B2 (en) | 2019-02-06 | 2021-08-03 | Synthorx, Inc. | IL-2 conjugates and methods of use thereof |
| JP7475445B2 (ja) | 2019-11-19 | 2024-04-26 | エスエフシー カンパニー リミテッド | 消光子およびこの用途 |
| JP2023503074A (ja) * | 2019-11-19 | 2023-01-26 | エスエフシー カンパニー リミテッド | 消光子およびこの用途 |
| JP2024000310A (ja) * | 2022-06-20 | 2024-01-05 | Ｔｏｐｐａｎホールディングス株式会社 | フラップエンドヌクレアーゼの蛍光基質における三重鎖構造の形成効率を向上させる方法 |
| JP7276571B1 (ja) | 2022-06-20 | 2023-05-18 | 凸版印刷株式会社 | フラップエンドヌクレアーゼの蛍光基質における三重鎖構造の形成効率を向上させる方法 |
Also Published As
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| US7348146B2 (en) | 2008-03-25 |
| CA2540551A1 (en) | 2005-04-21 |
| EP1670928A2 (en) | 2006-06-21 |
| US7718374B2 (en) | 2010-05-18 |
| US20050118623A1 (en) | 2005-06-02 |
| WO2005035545A3 (en) | 2005-07-28 |
| US20090087922A1 (en) | 2009-04-02 |
| WO2005035545A2 (en) | 2005-04-21 |
| AU2004279810A1 (en) | 2005-04-21 |
| EP1670928A4 (en) | 2008-06-25 |
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