JP2007506726A - α２δ−タンパク質に対する親和性を有するアミノ酸の使用方法 - Google Patents
α２δ−タンパク質に対する親和性を有するアミノ酸の使用方法 Download PDFInfo
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- JP2007506726A JP2007506726A JP2006527499A JP2006527499A JP2007506726A JP 2007506726 A JP2007506726 A JP 2007506726A JP 2006527499 A JP2006527499 A JP 2006527499A JP 2006527499 A JP2006527499 A JP 2006527499A JP 2007506726 A JP2007506726 A JP 2007506726A
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- Prior art keywords
- alkyl
- methyl
- acid
- phenyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 125000001153 fluoro group Chemical group F* 0.000 claims description 53
- -1 respectively Chemical group 0.000 claims description 50
- 229910052739 hydrogen Inorganic materials 0.000 claims description 40
- 239000001257 hydrogen Substances 0.000 claims description 37
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 34
- 125000004076 pyridyl group Chemical group 0.000 claims description 34
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 30
- 125000000217 alkyl group Chemical group 0.000 claims description 30
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 29
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- 125000001424 substituent group Chemical group 0.000 claims description 20
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- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 12
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Landscapes
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- Veterinary Medicine (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50600303P | 2003-09-25 | 2003-09-25 | |
| PCT/IB2004/002978 WO2005030184A2 (en) | 2003-09-25 | 2004-09-13 | Therapeutic beta aminoacids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007506726A true JP2007506726A (ja) | 2007-03-22 |
| JP2007506726A5 JP2007506726A5 (https=) | 2007-10-18 |
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| JP2006527499A Withdrawn JP2007506726A (ja) | 2003-09-25 | 2004-09-13 | α２δ−タンパク質に対する親和性を有するアミノ酸の使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7112610B2 (https=) |
| EP (1) | EP1670452A2 (https=) |
| JP (1) | JP2007506726A (https=) |
| KR (1) | KR100774625B1 (https=) |
| CN (1) | CN1856301A (https=) |
| AU (1) | AU2004275572A1 (https=) |
| BR (1) | BRPI0414798A (https=) |
| CA (1) | CA2539976A1 (https=) |
| IL (1) | IL173862A0 (https=) |
| MX (1) | MXPA06003381A (https=) |
| NO (1) | NO20061801L (https=) |
| RU (2) | RU2344121C2 (https=) |
| TW (1) | TW200511989A (https=) |
| WO (1) | WO2005030184A2 (https=) |
| ZA (1) | ZA200602450B (https=) |
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| CA2836449C (en) | 2011-05-17 | 2021-04-27 | The Regents Of The University Of California | Kinase inhibitors |
| US9376438B2 (en) | 2011-05-17 | 2016-06-28 | Principia Biopharma, Inc. | Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors |
| EA025496B1 (ru) | 2011-05-17 | 2016-12-30 | Принсипиа Биофарма Инк. | Ингибиторы тирозинкиназы |
| ME03455B (me) | 2012-09-10 | 2020-01-20 | Principia Biopharma Inc | Jedinjenja pirazolopirimidina kao inhibitori kinaze |
| US8957080B2 (en) | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| PT3107544T (pt) | 2014-02-21 | 2021-01-05 | Principia Biopharma Inc | Sais e forma sólida de um inibidor de btk |
| US10485797B2 (en) | 2014-12-18 | 2019-11-26 | Principia Biopharma Inc. | Treatment of pemphigus |
| TW201718572A (zh) | 2015-06-24 | 2017-06-01 | 普林斯匹亞生物製藥公司 | 酪胺酸激酶抑制劑 |
| MA45547A (fr) | 2016-06-29 | 2019-05-08 | Principia Biopharma Inc | Formulations à libération modifiée à base de 2-[3-[4-amino-3-(2-fluoro-4-phénoxy-phényl)pyrazolo[3,4-d]pyrimidine-1-yl]pipéridine-1-carbonyl]-4-méthyl-4-[4-(oxétane-3-yl)pipérazine-1-yl]pent-2-ènenitrile |
| TWI877239B (zh) | 2019-10-14 | 2025-03-21 | 美商普林斯匹亞生物製藥公司 | 藉由投予(R)-2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧呾-3-基)哌-1-基]戊-2-烯腈來治療免疫血小板減少症之方法 |
| JP2023511105A (ja) | 2020-01-22 | 2023-03-16 | プリンシピア バイオファーマ インコーポレイテッド | ２－［３－［４－アミノ－３－（２－フルオロ－４－フェノキシ－フェニル）－１ｈ－ピラゾロ［３，４－ｄ］ピリミジン－１－イル］ピペリジン－１－カルボニル］－４－メチル－４－［４－（オキセタン－３－イル）ピペラジン－１－イル］ペンタ－２－エンニトリルの結晶形態 |
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| RU2147574C1 (ru) * | 1991-08-23 | 2000-04-20 | Эн-Пи-Эс Фармасьютикалз, Инк. | Арилалкиламины, композиции, способы лечения и диагностики, способы идентификации соединения |
| US6306909B1 (en) * | 1997-03-12 | 2001-10-23 | Queen's University At Kingston | Anti-epileptogenic agents |
| FR2791982B1 (fr) * | 1999-04-06 | 2002-12-27 | Inst Nat Sante Rech Med | Inhibiteurs de lta4 hydrolase et leurs applications therapeutiques. |
| CA2440834A1 (en) * | 2001-03-13 | 2002-09-19 | Queen's University At Kingston | Anti-epileptogenic agents |
| NI200300043A (es) * | 2002-03-28 | 2003-11-05 | Warner Lambert Co | AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA. |
| GB0219024D0 (en) * | 2002-08-15 | 2002-09-25 | Pfizer Ltd | Synergistic combinations |
| CA2451267A1 (en) * | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| US20050043345A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US20050043407A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US20050043406A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
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2004
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- 2004-09-13 RU RU2006107650/04A patent/RU2344121C2/ru not_active IP Right Cessation
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- 2004-09-13 JP JP2006527499A patent/JP2007506726A/ja not_active Withdrawn
- 2004-09-13 CA CA002539976A patent/CA2539976A1/en not_active Abandoned
- 2004-09-13 MX MXPA06003381A patent/MXPA06003381A/es unknown
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2006
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2008
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2004275572A1 (en) | 2005-04-07 |
| RU2006107650A (ru) | 2007-10-27 |
| KR100774625B1 (ko) | 2007-11-08 |
| US20060247282A1 (en) | 2006-11-02 |
| CN1856301A (zh) | 2006-11-01 |
| RU2008137379A (ru) | 2010-03-27 |
| CA2539976A1 (en) | 2005-04-07 |
| TW200511989A (en) | 2005-04-01 |
| KR20060056391A (ko) | 2006-05-24 |
| BRPI0414798A (pt) | 2006-11-21 |
| EP1670452A2 (en) | 2006-06-21 |
| ZA200602450B (en) | 2007-09-26 |
| WO2005030184A2 (en) | 2005-04-07 |
| US7112610B2 (en) | 2006-09-26 |
| MXPA06003381A (es) | 2006-06-08 |
| WO2005030184A3 (en) | 2005-06-02 |
| NO20061801L (no) | 2006-06-02 |
| RU2344121C2 (ru) | 2009-01-20 |
| US20050124669A1 (en) | 2005-06-09 |
| IL173862A0 (en) | 2006-07-05 |
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