JP2007260382A - Core material for manufacture of catheter tube, manufacturing method thereof, catheter tube, and manufacturing method thereof - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a core material for manufacture of catheter tubes by which a safe catheter tube with sufficient lubricity can be easily obtained. <P>SOLUTION: While applying a tensile load in the longitudinal direction on one end of a fine metal line 3 with a polygonal section, the other end part in the longitudinal direction of the fine metal line 3 is gripped and rotated by a chuck 2 of a lath 1 to apply twist working on the fine metal line 3. Then distortion by the working is removed and the fine metal line 3 is heat-treated for softening. A pasty resin composition is coated on the twisted fine metal line as a core material. After the resin composition is hardened, the core material is extracted out from the resin coating to obtain a catheter tube comprising a hollow resin coating. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a core material for manufacturing a thin tubular catheter tube introduced into a blood vessel, digestive tract, or other body cavity (hereinafter referred to as “treatment tube required”) that requires treatment or examination, a method for manufacturing the same, and a method for manufacturing the same. The present invention relates to a catheter tube manufactured using a core material and a manufacturing method thereof.

  In order to introduce a catheter tube into a treatment tube of a human body that requires treatment or examination, it is necessary to introduce a medical guide wire to a required site prior to the introduction of the catheter tube. That is, in order for a medical practitioner (such as a doctor) to smoothly introduce a catheter tube to a required site along a medical guide wire, it can be smoothly inserted into a treatment-required tube by hand operation, and the catheter tube can be placed at a target site. Medical guide wires are required to be able to guide and introduce accurately. For this reason, the medical guide wire has a form adaptability (flexibility) that can be inserted without damaging the inner wall of the treatment required tube, corresponding to the inside of the treatment required tube having a complicatedly meandering tip. It is required that the base end part following the part has a torque transmission property capable of accurately transmitting torque even with a slight operation amount at hand.

  On the other hand, elasticity and toughness are required for a catheter tube that is guided by a medical guidewire and moves within a treatment tube. Of course, the catheter tube is required to be as thin and thin as possible in order to move within the treatment tube. A thermoplastic resin is generally used as a constituent material of a catheter tube having such characteristics.

  For example, in Patent Document 1, as shown in FIG. 11A, a liquid material is applied to the outer periphery of a rod-shaped core material 41 to form a liquid material coating layer 42, and then in FIG. As shown in FIG. 11, the liquid coating layer 42 is cured to form a coating 43, and then the core material 41 is removed from the coating 43 to obtain a catheter tube 44 as shown in FIG. 11 (c). A method is described. However, since the cross section of the core material 41 is circular, the inner surface of the catheter tube 44 is a smooth circle. However, if the inner surface is smooth and circular, when the catheter tube is introduced along the medical guide wire, a large frictional resistance is generated due to the entire contact between the inner surface of the catheter tube and the guide wire, and the catheter tube is smoothly introduced. It becomes difficult to do. Furthermore, in order to introduce the catheter tube into a narrower treatment tube, the guide wire inserted first is pulled out, a guide wire having a diameter smaller than that of the first one is inserted into the catheter tube, and the guide wire with a small diameter is inserted. After that, it may be necessary to withdraw the first catheter tube and introduce a smaller diameter catheter tube along the guide wire to the required site. Considering such circumstances, in order to smoothly introduce the catheter tube along the medical guidewire and insert the medical guidewire into the catheter tube, the contact area between the catheter tube and the medical guidewire It is necessary to reduce the frictional resistance by reducing. Therefore, the resistance of the catheter tube is reduced by reducing the contact area with the guide wire inserted by using a fluororesin with low friction resistance such as polytetrafluoroethylene or by forming minute irregularities on the inner surface of the catheter tube. There have been proposals to reduce and improve lubricity.

  As a countermeasure for reducing the frictional resistance, for example, it is conceivable to emboss the inner surface of the catheter tube by extrusion molding. Specifically, a method of cooling the vicinity of a resin outlet (lip) of an extrusion die, or a method of extrusion using a deformed die is known. However, the method by lip cooling is relatively widely performed on the outer surface of the tube, but the inner surface is very difficult for a small-diameter tube due to the structure of the die, and is partially performed by inflation molding with a large die. Only. In addition, in the molding using a deformed die, only a strip-shaped streak can be inserted and the tube cannot be covered with a resin, so that a small-diameter tube cannot be manufactured.

  Further, methods for reducing the frictional resistance between the catheter tube and the medical guide wire have been proposed in the following Patent Documents 2 to 4.

  That is, Patent Document 2 describes a method of extruding a thermoplastic resin and vibrating the inner mold provided in the molten resin passage to form irregularities on the contact surface of the resin with the inner mold. Yes.

  Further, in Patent Document 3, a coating made of a silicone resin and an inorganic powder is applied to a metal linear body, and after baking to form a primary coating film, a resin for forming a tube is applied and baked. Thereafter, a method is described in which the elongation below the yield point is given to the metal linear body, the tube is peeled off from the primary coating film, and a tube having minute irregularities on the inner surface is formed.

Furthermore, Patent Document 4 describes a method in which a core resin having a tube formed on a core wire on which many fine concave portions are formed on the outer surface by embossing is formed, and then the core wire is pulled out.
JP-A-9-285545 Japanese Patent Publication No. 1-16653 Japanese Patent Publication No. 6-4301 JP-A-8-24342

  However, the method described in Patent Document 2 requires a large-scale device for vibrating the inner mold, and it is very difficult to control the vibration stroke of the inner mold and the extrusion speed for forming minute irregularities. It is. Further, there is a disadvantage that uneven thickness is generated by vibrating the inner mold, and unnecessary irregularities are formed on the outer surface side of the tube, thereby reducing dimensional stability. Therefore, it is difficult to apply to the manufacture of a catheter tube that requires high dimensional stability.

  In addition, in the method described in Patent Document 3, the inorganic powder is dropped from the metal linear body during the manufacturing process, unevenness is uneven, the inorganic powder remains in the tube, and the catheter tube is inserted into the body. Sometimes it can have a negative effect. Further, in this method, since the convex portion of the inorganic powder is formed on the metal linear body and the tube is formed thereon, the obtained tube has a structure in which minute irregularities are formed on the substantially flat inner surface. Thus, the frictional resistance when the guide wire is inserted is not reduced so much.

  Furthermore, in the method described in Patent Document 4, since the core wire that has been embossed bites into the inner surface of the tube, it becomes difficult to pull out, and the inner surface of the tube may be damaged if it is forcibly pulled out.

  Thus, there has not yet been obtained a catheter tube having an inner diameter of about 1 mm or less and an inner surface of which is rugged enough to significantly reduce the frictional resistance of the guide wire.

  The present invention has been made in view of such problems of the prior art, and an object of the present invention is to easily obtain a catheter tube which is safe and lubricious (low frictional resistance). Another object of the present invention is to provide a catheter tube manufacturing core material, a manufacturing method thereof, a catheter tube manufactured using the core material, and a manufacturing method thereof.

  In order to achieve the above object, the core material for manufacturing a catheter tube of the present invention is characterized by comprising a twisted metal wire that can be obtained by twisting a metal wire having a polygonal cross section. Moreover, the core material for manufacturing a catheter tube of the present invention is characterized by comprising a metal twisted wire obtained by twisting a plurality of metal strands.

  Moreover, the manufacturing method of the core material for manufacturing a catheter tube according to the present invention is to twist a metal thin wire having a polygonal cross section manufactured through cold working including wire drawing, and then to the metal thin wire. It is characterized in that a core material for manufacturing a catheter tube made of a fine metal wire to which twisting is applied is performed by performing heat treatment for removing distortion and softening due to processing.

  Further, the catheter tube of the present invention is characterized in that strip-shaped wire guide portions and spiral grooves that protrude in a spiral shape are formed alternately along the longitudinal direction of the inner surface. The catheter tube of the present invention is characterized in that spiral wire guide protrusions and spiral grooves are alternately formed along the longitudinal direction of the inner surface.

  Further, in the method for producing a catheter tube of the present invention, a core material composed of a twisted metal fine wire or a metal twisted wire obtained by twisting a plurality of metal strands is coated with a paste-like resin composition, and then paste-like The resin composition is solidified to form a resin film, and the core material is removed from the resin film to obtain a catheter tube made of a hollow resin film.

  Since this invention is comprised as mentioned above, there exists the following effect.

  According to the first and second aspects of the invention, it is possible to provide a fine metal wire or a twisted metal wire that is suitable as a core material for manufacturing a catheter tube that is safe and rich in lubricity.

  According to invention of Claim 3, torsion processing is given to the metal fine wire which has the polygonal cross section manufactured through the cold work including wire drawing, and the removal of the distortion accompanying a process with respect to the said metal fine wire is carried out after that. Further, by performing heat treatment for softening, a core material for manufacturing a catheter tube that can withstand repeated use with high ductility can be manufactured.

  According to the fourth and fifth aspects of the present invention, since the spiral groove is formed in the longitudinal direction of the inner surface of the catheter tube, when the guide wire is inserted into the catheter tube, the inner surface of the catheter tube and the guide wire A flexible medical guide wire along the strip-shaped wire guide portion or spiral wire guide protrusion formed on the inner surface of the catheter tube to reduce frictional resistance by reducing the contact area of the wire The tip can be inserted smoothly. Further, since the frictional resistance is reduced, the catheter tube can be smoothly introduced to a required site along the medical guide wire introduced prior to the introduction of the catheter tube.

  According to the sixth aspect of the present invention, it is possible to manufacture a catheter tube that is safe and rich in lubricity.

Below, the form for implementing this invention is divided and demonstrated.
(1) Catheter tube manufacturing core material and catheter tube made of fine metal wires As the material of the metal fine wire constituting the catheter tube manufacturing core material of the present invention, ductile materials such as steel, copper, stainless steel and aluminum are used. Good metals are preferable, and the surface of these metals may be plated with a different metal.

  The fine metal wire having a polygonal cross section preferably has a regular polygon cross section up to a regular octagon. In a regular polygon that exceeds a regular octagon, the cross-sectional shape is close to a circle, and the contact area between the catheter tube and the guide wire manufactured from a core obtained by twisting a thin metal wire having such a cross-sectional shape This is because the effect of reducing frictional resistance cannot be expected.

  The twist pitch (P in FIG. 2) applied to the fine metal wire is preferably 2.5 to 20 times the diameter of the inscribed circle (D in FIG. 5). If it is less than 2.5 times, the torsion pitch is too short and breakage may occur during the production of the fine metal wire. On the other hand, if it exceeds 20 times, the torsion pitch becomes too long to form a spiral groove. This is because it is difficult to expect the effect of reducing frictional resistance.

  The breaking elongation of the fine metal wire is preferably 50% or more. This is because when it is less than 50%, it is difficult to remove the core material produced from such a fine metal wire from the hollow resin coating when the catheter tube is produced.

  As a means for twisting the fine metal wire, for example, one end of the fine metal wire in the longitudinal direction is connected to a stationary load and a tensile load is applied in the longitudinal direction of the fine metal wire, By twisting the other end of the direction with a lathe chuck and rotating the lathe spindle at a low speed (100 to 400 rpm), the fine metal wire can be twisted.

  Moreover, even if it uses a well-known buncher type strand wire machine, a metal thin wire can be twisted.

  The heat treatment applied to the fine metal wires for the removal of strain and softening due to processing can be selected in the range of about 500 to 1100 ° C., although it depends on the type of metal. By applying heat treatment to the fine metal wires at such a temperature, the strain associated with the processing is removed, and when the catheter tube is manufactured by a method described later using the fine metal wires as a core material, the core material is easily stretched. Can be easily removed from the resin coating.

In the part where the inner surface of the catheter tube manufactured by the core made of the thin metal wire is separated from the line defining the inscribed circle (the diameter of the inscribed circle corresponds to the diameter of the guide wire) (see FIG. 5) and the maximum distance (t in FIG. 5) between the line defining the inscribed circle (the dotted line defining the circle in FIG. 5) is 2 to 2 of the diameter of the inscribed circle (D in FIG. 5). 15% is preferred. If it is less than 2%, the groove is too shallow and it is difficult to expect the effect of reducing frictional resistance. On the other hand, if it exceeds 15%, the thickness of the catheter tube becomes thin and easily breaks. If the thickness of the catheter tube in this portion is increased in order to prevent this breakage, the other portion also becomes thick and the catheter tube becomes flexible. This is because the sex is lowered.
(2) Core material for producing a catheter tube made of a twisted metal wire As a material of a metal strand constituting a twisted metal wire that becomes a core material for producing a catheter tube of the present invention, steel, copper, stainless steel, aluminum and the like Metals having good spreadability are preferable, and the surface of these metals may be plated with a different metal.

  As an example of the metal stranded wire, as shown in FIGS. 6 (a) and 6 (b), a steel of 1 × n stranded structure (where n is the number of metal strands and n = 3 to 6) called single-layer stranded wire. Codes 21 and 22 can be used. The number of metal strands M of the steel cord 21 is 3, and the number of metal strands M of the steel cord 22 is 5. Further, as shown in FIGS. 7 (a) and 7 (b), steel cords 23 and 24 having a 1 × n twist structure (n is the number of metal strands and n = 12, 19, and 27) called bundle twist are provided. Can be used. The number of metal strands M of the steel cord 23 is 12, and the number of metal strands M of the steel cord 24 is 27. Further, as shown in FIGS. 8 (a), (b) and (c), k + m or k + m + n twist structure called multi-layer twist (k is the number of metal strands in the innermost layer, k = 1 to 3, m is Steel cords 25, 26, and 27 in which the number of metal strands in the intermediate layer is m = 6 to 9 and n is the number of metal strands in the outermost layer and n = 12 to 15) can be used. The number of metal strands k of the steel cord 25 is 3, the number of metal strands m is 9, the number of metal strands k of the steel cord 26 is 1, the number of metal strands m is 6, and the number of metal strands n is 12. The number of metal strands k of the steel cord 27 is 3, the number of metal strands m is 9, and the number of metal strands n is 15.

  In addition to those shown in FIGS. 6 to 8, other twisted metal twisted wires can be adopted as long as they are suitable for the production of a safe and lubricious catheter tube. Needless to say.

  These metal twisted wires can be manufactured using a known buncher type twisted wire machine or a tubular type twisted wire machine.

Moreover, it is preferable to heat-treat also with respect to a metal twisted wire for the removal of the distortion accompanying twisting, and softening. This heat treatment temperature can be selected in the range of about 500 to 1100 ° C., although it depends on the type of metal wire. By applying heat treatment to the twisted metal wire at such a temperature, the strain associated with the processing is removed, and when the catheter tube is manufactured by a method described later using the twisted metal wire as a core material, the core material is stretched. It can be made easy to be easily removed from the resin coating.
(3) Paste resin composition The paste resin composition for coating the core material is obtained by dissolving an organic compound in a solvent, such as polyethylene, polypropylene, ethylene-propylene copolymer, ethylene-propylene-diene copolymer. Thermoplastic resins such as coalescence, polyacetal, polyamide, polyvinyl chloride, polycarbonate, polyvinyl acetate, polystyrene, and polysulfone can be preferably used. In particular, polypropylene can be preferably used. Among them, polypropylene obtained by highly polymerizing propylene under special conditions using a Ziegler-Natta catalyst is rich in isotactic structure (80 to 90%), and thus exhibits high crystallinity and a high melting point ( 165 ° C.), the density is 0.91 g / cm ³ , the smallest among plastics, and the mechanical strength is superior to that of polyethylene. In addition, the polypropylene having this isotactic structure has all methyl groups appearing on one side, has regularity, high crystallinity, a translucent resin with a large surface hardness, and is hardly scratched. It has excellent properties such as chemical resistance and oil resistance, is extremely resistant to repeated bending, and has good electrical insulation properties. Therefore, as the paste-like resin composition for covering the core material, polypropylene having an isotactic structure is particularly preferable.

  Moreover, as a covering means to the core material of the paste-like resin composition, it can be performed by extrusion molding, application, dipping or the like of the resin material on the outer surface of the core material. Among these, the wire coating method in which the resin is extruded from a small die while moving the elongated core material in the longitudinal direction and sequentially coated is preferable because a small-diameter tube made of a hollow resin film can be obtained with good dimensional stability.

Examples of the present invention will be described below. However, the present invention is not limited to the following examples, and can be appropriately changed or modified without departing from the technical scope of the present invention.
A. Manufacture of a catheter tube using a core material made of a twisted metal wire (1) Manufacture of a core material a. Production of a fine metal wire having a square cross section by wire drawing and rolling A steel having a composition shown in Table 1 (equivalent to SUS304: wt%) is melted in an electric melting furnace, and after hot forging, a wire having a diameter of 5.5 mm is formed. Obtained by hot rolling. Next, the wire was cold drawn to a diameter of 0.43 mm by repeatedly performing wire drawing and solution heat treatment, and then the width of one side was 0.4 mm and the radius of curvature of the corner was 0 with a four-way rolling mill. A square wire having a substantially square shape in cross section with a flat portion length of 0.21 mm at each side of 0.15 mm was obtained, and a wire having a square cross section was cut into a length of 1000 mm.

  If a deformed die is used, it is possible to obtain a wire having a polygonal cross section only by wire drawing.

B. Twisting into a fine metal wire having a square cross section The chuck 2 of the lathe 1 shown in FIG. 1 grips one end of a wire 3 having a square cross section and connects the other end of the wire 3 to a load 4 (fixing member). The load 4 was fixed to the lathe 1 so that the load 4 did not move freely, and a tensile load was applied in the longitudinal direction of the wire 3.

When the main shaft in the rotation drive unit 5 of the lathe 1 is rotated and one end side of the wire 3 is rotated together with the chuck 2 at a rotation speed of 250 rpm for 1 minute, the other end side of the wire 3 is loaded 4. Therefore, the wire rod 3 is twisted and has a side surface as shown in FIG. 2 and a cross-section as shown in FIG. The material was obtained. In FIG. 2, the twist pitch P is about 4 mm. In FIG. 2, the white portion is a portion that retains a shape close to the original square shape, and the inner surface of the catheter tube manufactured by such a method using such a core material is white and white. A strip-shaped wire guide portion protruding in a spiral shape corresponding to the sandwiched gray portion is formed, and a spiral spiral groove is formed by the white spiral portion and the gray spiral portion. .
C. Heat treatment In order to remove strain and soften the wire drawing, rolling and twisting applied to each of the above-mentioned metal thin wires, a solid heat treatment at 1050 ° C. was performed on the metal thin wires using a continuous heat treatment furnace. In addition, in order to measure the breaking elongation of the fine metal wires, a twisted metal wire is produced from the steel having the composition shown in Table 1 according to the above-mentioned process, and the breaking elongation after the solution heat treatment for the fine metal wires is measured. 60%.
(2) Manufacture of catheter tube The outer periphery of the core material obtained by the heat treatment was coated with polypropylene (having an isotactic structure) by a normal wire coating method. Next, the polypropylene film of about 30 mm on both ends of the core material was scraped with sandpaper to expose the core material. Then, one end of the exposed core material is fixed, and the other end is pulled to reduce the diameter of the core material. Thereafter, the core material is removed, and a polypropylene catheter tube 7 having a longitudinal section as shown in FIG. Obtained. FIG. 5 is an enlarged sectional view taken along the line VV in FIG. As shown in FIG. 4, the inner surface of the catheter tube 7 is formed with a strip-shaped wire guide portion 9 that slightly protrudes spirally toward the central axis 8 and is sandwiched between the strip-shaped wire guide portions 9 and 9. When the spiral-shaped portion 10 is slightly recessed from the wire guide portion 9, the longitudinal direction of the inner surface of the catheter tube 7 has a spiral wire-shaped wire guide portion 9 and a spiral undulation. Grooves are formed alternately.

In FIG. 5, the dotted line indicates an inscribed circle, and the diameter D of the inscribed circle is 0.4 mm. In FIG. 5, the inner surface 11 of the catheter tube 7 is separated from the line defining the inscribed circle (dotted line in FIG. 5) between the inner surface 11 of the catheter tube 7 and the line defining the inscribed circle. The maximum value (t) of the distance is 0.015 mm (3.75% of the inscribed circle diameter).
B. Manufacture of a catheter tube using a core material composed of a metal strand obtained by twisting a plurality of metal strands (1) Manufacture of a core material SWRW62A equivalent (JIS standard) of the composition (% by weight) shown in the following Table 2 A steel wire having a diameter of 5.5 mm is repeatedly drawn and heat-treated (annealed) to obtain a metal strand by cold drawing to a diameter of 0.15 mm, and then using a known buncher type twisting machine. A single-layer stranded metal stranded wire 29 in which five metal strands 28 having a side surface as shown in FIG. 9 (a) and a cross section as shown in FIG. 9 (b) were twisted was obtained. The bundle of the stranded metal wires 29 is subjected to a heat treatment at a temperature of 700 ° C. for 10 hours using a batch heat treatment furnace, and then the stranded metal wires are cut into a length of 1000 mm to produce a core for manufacturing a catheter tube. The material was obtained. The tensile strength of the metal stranded wire after the heat treatment was 508 N / mm ² and the elongation at break was 22%.

  In addition, the catheter tube which consists of a metal strand wire which gave the heat treatment for the removal and softening of the distortion accompanying a wire drawing to the metal strand before a strand wire processing, and twisted the several metal strand after this heat processing A core material for production can also be obtained.

(2) Manufacture of catheter tube The outer periphery of the core material obtained by the heat treatment was coated with polypropylene (having an isotactic structure) by a normal wire coating method. Next, the polypropylene film of about 30 mm on both ends of the core material was scraped with sandpaper to expose the core material. Then, one end of the exposed core material is fixed, and the other end is pulled to reduce the diameter of the core material. Thereafter, the core material is removed, and a polypropylene catheter tube 30 having a longitudinal section as shown in FIG. Obtained. As shown in FIG. 10, a spiral wire guide protrusion 32 that slightly protrudes toward the central axis 31 is formed on the inner surface of the catheter tube 30, and the spiral wire guide protrusion 32 and When the spiral portion 33 sandwiched between 32 is slightly recessed from the wire guide protrusion 32, the spiral wire guide protrusion 32 and the spiral undulation are formed in the longitudinal direction of the inner surface of the catheter tube 30. A certain groove is formed alternately.

It is a figure explaining the method of giving a twist process to a metal fine wire. It is a one part enlarged side view of the longitudinal direction of an example of the metal fine wire to which the twist process was performed according to the method of this invention. FIG. 3 is an enlarged sectional view taken along the line III-III in FIG. 2. It is an expanded sectional view of a part in the longitudinal direction of an example of a catheter tube manufactured according to the method of the present invention. It is a VV arrow expanded sectional view of FIG. 6 (a) and 6 (b) are cross-sectional views of single-layer stranded steel cords. FIGS. 7A and 7B are cross-sectional views of bundle-twisted steel cords. FIGS. 8A, 8B, and 8C are cross-sectional views of multi-layered steel cords, respectively. Fig. 9 (a) is an enlarged side view of a part of the longitudinal direction of a steel cord of a single-layer twist in which five metal strands are twisted together, and Fig. 9 (b) is a view taken along arrows XI-XI in Fig. 9 (a). It is an expanded sectional view. FIG. 6 is an enlarged cross-sectional view of a part of a longitudinal direction of another example of a catheter tube manufactured according to the method of the present invention. 11 (a), 11 (b), and 11 (c) are diagrams showing an example of a conventional method for manufacturing a catheter tube.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Lathe 2 Chuck 3 Wire 4 Load 5 Rotation drive part 6 Metal thin wire 7 Catheter tube 8 Center axis 9 Spiral strip-shaped wire guide part 10 Spiral part 11 Inner surface of catheter tube 21 Single layer stranded steel cord 22 Single Layer-twisted steel cord 23 Bundle-twisted steel cord 24 Bundle-twisted steel cord 25 Multi-layer stranded steel cord 26 Multi-layer stranded steel cord 27 Multi-layer stranded steel cord 28 Metal strand 29 Metal stranded wire 30 Catheter tube 31 Central shaft 32 Spiral Wire guide protrusion 33 Spiral part M Metal wire

Claims (6)

  A core material for manufacturing a catheter tube, which is obtained by twisting a fine metal wire having a polygonal cross section, and comprising a twisted metal fine wire.   A core material for manufacturing a catheter tube, which is made of a stranded metal wire obtained by twisting a plurality of metal strands.   By twisting a metal thin wire having a polygonal cross section manufactured through cold working including wire drawing, and then subjecting the metal thin wire to heat treatment for removing strain and softening due to processing A method for producing a core material for producing a catheter tube, comprising obtaining a core material for producing a catheter tube comprising a twisted metal fine wire.   A catheter tube in which strip-shaped wire guide portions and spiral grooves that protrude in a spiral shape along the longitudinal direction of the inner surface are alternately formed.   A catheter tube in which spiral wire guide protrusions and spiral grooves are alternately formed over the longitudinal direction of the inner surface.   The core material according to claim 1 or 2 is coated with a paste-like resin composition, and then the paste-like resin composition is solidified to form a resin film. Further, the core material is removed from the resin film to form a hollow resin film. A catheter tube manufacturing method, comprising:

Images