JP2007204489A - Method for preventing discoloring of hair grower comprising minoxidil formulated therein - Google Patents
Method for preventing discoloring of hair grower comprising minoxidil formulated therein Download PDFInfo
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- JP2007204489A JP2007204489A JP2007105393A JP2007105393A JP2007204489A JP 2007204489 A JP2007204489 A JP 2007204489A JP 2007105393 A JP2007105393 A JP 2007105393A JP 2007105393 A JP2007105393 A JP 2007105393A JP 2007204489 A JP2007204489 A JP 2007204489A
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- minoxidil
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- hair grower
- container
- discoloration
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- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 title claims abstract description 17
- 229960003632 minoxidil Drugs 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 title claims abstract description 7
- -1 polyethylene terephthalate Polymers 0.000 claims abstract description 20
- 229920000139 polyethylene terephthalate Polymers 0.000 claims abstract description 16
- 239000005020 polyethylene terephthalate Substances 0.000 claims abstract description 16
- 229920003023 plastic Polymers 0.000 claims abstract description 6
- 239000004033 plastic Substances 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 abstract description 9
- 238000002845 discoloration Methods 0.000 abstract 4
- 238000012216 screening Methods 0.000 abstract 2
- 239000011521 glass Substances 0.000 abstract 1
- 239000012780 transparent material Substances 0.000 abstract 1
- 238000004040 coloring Methods 0.000 description 8
- 239000004698 Polyethylene Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 229920000573 polyethylene Polymers 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- FWKQNCXZGNBPFD-UHFFFAOYSA-N Guaiazulene Chemical compound CC(C)C1=CC=C(C)C2=CC=C(C)C2=C1 FWKQNCXZGNBPFD-UHFFFAOYSA-N 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
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- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- CZHLPWNZCJEPJB-UHFFFAOYSA-N 1-chloro-3-methylbutane Chemical compound CC(C)CCCl CZHLPWNZCJEPJB-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 1
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
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- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
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- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
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- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
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- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
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- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 235000008694 Humulus lupulus Nutrition 0.000 description 1
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- 244000178231 Rosmarinus officinalis Species 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
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- 230000004888 barrier function Effects 0.000 description 1
- 229920005601 base polymer Polymers 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
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- 239000004202 carbamide Substances 0.000 description 1
- 235000014171 carbonated beverage Nutrition 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
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- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
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- 235000013305 food Nutrition 0.000 description 1
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- 239000007789 gas Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229960002350 guaiazulen Drugs 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 239000003410 keratolytic agent Substances 0.000 description 1
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- 229940041616 menthol Drugs 0.000 description 1
- OJURWUUOVGOHJZ-UHFFFAOYSA-N methyl 2-[(2-acetyloxyphenyl)methyl-[2-[(2-acetyloxyphenyl)methyl-(2-methoxy-2-oxoethyl)amino]ethyl]amino]acetate Chemical compound C=1C=CC=C(OC(C)=O)C=1CN(CC(=O)OC)CCN(CC(=O)OC)CC1=CC=CC=C1OC(C)=O OJURWUUOVGOHJZ-UHFFFAOYSA-N 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
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- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 description 1
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- TXGSOSAONMOPDL-UHFFFAOYSA-N propan-2-yl 3,4,5-trihydroxybenzoate Chemical compound CC(C)OC(=O)C1=CC(O)=C(O)C(O)=C1 TXGSOSAONMOPDL-UHFFFAOYSA-N 0.000 description 1
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- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
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Abstract
Description
本発明は、ミノキシジルを配合した育毛剤の着色防止方法に関する。 The present invention relates to a method for preventing coloring of a hair restorer containing minoxidil.
ミノキシジルは、化学名を６−（１−ピペリジニル）−２，４−ピリジンジアミン−３−オキサイドと称し、育毛剤としての適用が記載されている（特許文献１参照）。 Minoxidil has a chemical name of 6- (1-piperidinyl) -2,4-pyridinediamine-3-oxide, and its application as a hair restorer is described (see Patent Document 1).
ミノキシジルを配合した育毛剤は、世界的に使用され脱毛症の治療に用いられている。しかし、外国の製品は、経時的に製剤が黄色に変色する欠点があり、使用時に衣類の汚れや使用感の低下など製品価値を低下させる場合があった。ミノキシジル配合の育毛剤容器の材質としてはＰＥ（ポリエチレン）が用いられているが、経時着色するので好ましい材質の容器とは言い難い。 Hair restorers containing minoxidil are used worldwide to treat alopecia. However, foreign products have the disadvantage that the formulation turns yellow over time, and there are cases where the product value is reduced during use, such as dirt on clothes and a decrease in feeling of use. Although PE (polyethylene) is used as the material for the hair-growth container containing minoxidil, it is difficult to say that it is a preferable material because it is colored over time.
ポリエチレンテレフタレート製プラスチック（ＰＥＴ）は、透明性がよく、強度的にもすぐれているうえ、気体や水分等の遮断性があり、耐熱性がある。コーラ飲料容器、炭酸飲料、しょうゆなどの大型ボトルに広く使われている。 Polyethylene terephthalate plastic (PET) has good transparency and strength, and has a barrier property against gases and moisture, and has heat resistance. Widely used in large bottles such as cola drink containers, carbonated drinks and soy sauce.
本発明の目的は、ミノキシジルを配合した育毛剤の経時的な着色を防止する方法を提供することにある。 An object of the present invention is to provide a method for preventing coloration over time of a hair restorer containing minoxidil.
本発明者らは、ある種の材質の容器を用いれば製剤の経時的な着色を防ぐことができることを見出し、本発明を完成した。 The present inventors have found that the use of a container made of a certain kind of material can prevent the coloration of the preparation over time, thereby completing the present invention.
すなわち、本発明は、実質的にポリエチレンテレフタレート製プラスチックで構成される容器に封入することを特徴とする、ミノキシジル配合育毛剤の着色防止方法である。 That is, the present invention is a method for preventing coloring of a minoxidil-containing hair restorer, characterized by being enclosed in a container substantially made of polyethylene terephthalate plastic.
後の試験例記載の通り、ポリエチレンテレフタレート製容器に充填した場合、ミノキシジルを配合した育毛剤の経時的な着色を防ぐことが可能になった。一方、従来使われていたポリエチレンまたはポリプロピレン製の容器では着色防止効果は不十分であった。 As described later in the test examples, when a polyethylene terephthalate container was filled, it became possible to prevent coloring of the hair restorer containing minoxidil over time. On the other hand, the conventionally used containers made of polyethylene or polypropylene have an insufficient anti-coloring effect.
本発明で使用する容器の材質は、テレフタル酸またはそのジメチルエステルとエチレングリコールを出発原料とする重合成分を５０％以上含む基ポリマーを主成分とするポリエチレンテレフタレート製プラスチック（ＰＥＴ）である。 The material of the container used in the present invention is polyethylene terephthalate plastic (PET) whose main component is a base polymer containing 50% or more of a polymerization component starting from terephthalic acid or its dimethyl ester and ethylene glycol.
本発明で使用する容器は、食品、添加物等の規格基準、乳等省令、米国のＦＤＡ規格（２１ＣＦＲ）で規格されている程度のものであればよい。その他のポリエステルなどのプラスチックを発明の効果を損なわない程度配合することもでき、実質的にＰＥＴ（ポリエチレンテレフタレート）であればよい。 The container used in the present invention may be of a level that is standardized by standard standards for foods, additives, etc., ministerial ordinances such as milk, and US FDA standards (21 CFR). Other plastics such as polyester can be blended to such an extent that the effects of the invention are not impaired, and may be substantially PET (polyethylene terephthalate).
ミノキシジルは薬理活性が高く、十分な育毛剤効果を得るために、１日の投与量を正確にする必要があり、定量注出型の容器は必要になっている。この定量注出型容器本体の材質としても、ＰＥＴ（ポリエチレンテレフタレート）が好ましいが、特にアプリケーター部分の材質に関して、計量部分がポリエチレン、ポリプロピレン、ポリアセタール、ポリメチルペンテンから選ばれ、塗布部分がジメチルシリコン、および容器内に浸漬するチューブがポリエチレンで構成される容器が硬度の面から好ましい。 Minoxidil has high pharmacological activity, and in order to obtain a sufficient hair restorer effect, it is necessary to make the daily dose accurate, and a quantitative dispensing type container is necessary. PET (polyethylene terephthalate) is also preferable as the material of the quantitative pouring type container main body, but particularly the material of the applicator part is selected from polyethylene, polypropylene, polyacetal, polymethylpentene, and the application part is dimethylsilicone. A container in which the tube immersed in the container is made of polyethylene is preferable from the viewpoint of hardness.
さらに１回使い捨てタイプのユニットドーズ容器では、一般に成形しやすく、スクイズ性に優れるポリエチレンが材質に用いられているが、ミノキシジル製剤では経時着色や、製剤中の溶媒の揮散が著しいという問題があった。 Furthermore, in single-use type unit dose containers, polyethylene that is generally easy to mold and has excellent squeeze properties is used as the material. However, in the case of minoxidil preparations, there was a problem that coloring with time and volatilization of the solvent in the preparations were significant. .
しかし、上記ＰＥＴ（ポリエチレンテレフタレート）を用いれば着色および溶媒の揮散の何れも防ぐことができる。 However, if PET (polyethylene terephthalate) is used, both coloring and solvent evaporation can be prevented.
本発明は、育毛剤として用いられる通常の剤型、例えばローション剤、乳液、懸濁剤、トニック剤、クリーム剤、軟膏剤などの製剤で着色防止効果を得ることができる。 The present invention can obtain an anti-coloring effect in a conventional dosage form used as a hair restorer, such as a lotion, emulsion, suspension, tonic, cream, ointment and the like.
製剤の成分としてはミノキシジル以外にも、本発明の効果を損なわない限り、塩酸ジフェンヒドラミン、塩酸イソペンジル等の抗ヒスタミン剤、グリチルレチン酸、グアイアズレン等の抗炎症剤、尿素、サリチル酸等の角質溶解剤、グルコン酸クロルヘキシジン、イソプロピルメチルフェノール、第４級アンモニウム塩、ヒノキチオール、ピロクトンオラミン等の殺菌剤、ヒアルロン酸ナトリム、グリセリン、コンドロイチン硫酸等の保湿剤、イチイ、ボタンピ、カンゾウ、オトリギソウ、附子、ビワ、カワラヨモギ、コンフリー、アシタバ、サフラン、サンシン、ローズマリー、セージ、モッコウ、セイモッコウ、ホップ、プラセンタ等の動植物の抽出物、酢酸レチノール、塩酸ピリドキシン、アスコルビン酸、硝酸チアミン、シアノコバラミン、ビオチン、酢酸トコフェロール等のビタミン類、スクワラン、流動パラフィン、レシチン等の油分、ポリオキシエチレン硬化ヒマシ油等の界面活性剤、メントール、カンフル等の精油成分、ジブチルヒドロキシトルエン、イソプロピルガレート等の抗酸化剤、エチレンジアミンテトラアセテートまたはその塩等の金属イオン封鎖剤、色素、香料等を配合することができる。 In addition to minoxidil, the components of the preparation are antihistamines such as diphenhydramine hydrochloride and isopentyl hydrochloride, anti-inflammatory agents such as glycyrrhetinic acid and guaiazulene, keratolytic agents such as urea and salicylic acid, and chlorhexidine gluconate, as long as the effects of the present invention are not impaired. , Isopropyl methylphenol, quaternary ammonium salt, hinokitiol, piroctone olamine, etc., moisturizers such as sodium hyaluronate, glycerin, chondroitin sulfate, yew, button pi, licorice, hygiensis, appendix, loquat, kawara mugi Free, ashitaba, saffron, sancin, rosemary, sage, mokko, seimokko, hops, placenta and other animal and plant extracts, retinol acetate, pyridoxine hydrochloride, ascorbic acid, thiamine nitrate, cyanocoba Minerals, biotin, vitamins such as tocopherol acetate, oils such as squalane, liquid paraffin, lecithin, surfactants such as polyoxyethylene hydrogenated castor oil, essential oil components such as menthol and camphor, and antibacterials such as dibutylhydroxytoluene and isopropyl gallate An oxidant, a sequestering agent such as ethylenediaminetetraacetate or a salt thereof, a dye, and a fragrance can be blended.
以下、試験例により本発明を詳細に説明する。 Hereinafter, the present invention will be described in detail by test examples.
以下に示した処方の育毛剤を常法により調製し、ポリエチレンテレフタレート製の容器に充填した。
（処方）
ミノキシジル １．０ｇ
プロピレングリコール ２０．０ｇ
エタノール ６０．０ｍｌ
精製水 全１００．０ｍｌ
A hair restorer having the following formulation was prepared by a conventional method and filled in a polyethylene terephthalate container.
(Prescription)
Minoxidil 1.0g
Propylene glycol 20.0g
Ethanol 60.0ml
100.0 ml of purified water
試験例１（製剤の経時着色に及ぼすポリエチレンテレフタレートの容器の効果）
実施例１の処方に示した内容物を表１に示す各種の材質から成る容器に入れ、室温、窓際太陽光の条件で６Ｍまで保存し、終了後製剤の着色を４２０ｎｍの吸光度で評価した。結果を表１に示す。
Test Example 1 (Effect of container of polyethylene terephthalate on coloration of preparation over time)
The contents shown in the formulation of Example 1 were put in containers made of various materials shown in Table 1, and stored up to 6M under conditions of room temperature and sunlight at the window. After completion, the coloring of the preparation was evaluated by absorbance at 420 nm. The results are shown in Table 1.
本願発明はミノキシジルを配合した育毛剤、医薬品として使用可能である。 The present invention can be used as a hair-restoring agent or pharmaceutical agent containing minoxidil.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007105393A JP5323324B2 (en) | 2007-04-13 | 2007-04-13 | Method for preventing coloring of minoxidil-containing hair restorer and container filled with minoxidil-containing hair restorer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007105393A JP5323324B2 (en) | 2007-04-13 | 2007-04-13 | Method for preventing coloring of minoxidil-containing hair restorer and container filled with minoxidil-containing hair restorer |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9211875A Division JPH1146849A (en) | 1997-08-06 | 1997-08-06 | Container for minoxyzyl-blended hair tonic |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012039726A Division JP2012144536A (en) | 2012-02-27 | 2012-02-27 | Method for preventing discoloring of minoxidil-containing hair grower |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007204489A true JP2007204489A (en) | 2007-08-16 |
| JP5323324B2 JP5323324B2 (en) | 2013-10-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2007105393A Expired - Lifetime JP5323324B2 (en) | 2007-04-13 | 2007-04-13 | Method for preventing coloring of minoxidil-containing hair restorer and container filled with minoxidil-containing hair restorer |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017052756A (en) * | 2015-09-10 | 2017-03-16 | 大正製薬株式会社 | Minoxidil-containing formulation contained in pump container |
| CN115501178A (en) * | 2022-08-26 | 2022-12-23 | 山东京卫制药有限公司 | Stable liquid composition containing minoxidil and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56101345A (en) * | 1980-01-17 | 1981-08-13 | Toshiba Corp | Stator of electric rotary machine |
| JPS6236367A (en) * | 1985-07-19 | 1987-02-17 | ヴインチエンツオ・ザツピア | Monoxidil salt, its production and external remedy or cosmetics containing said salt as effective component |
| JPH0240315A (en) * | 1988-06-17 | 1990-02-09 | L'oreal Sa | Composition based on amphoteric surfactant and pyrimidine derivative |
| JPH03145421A (en) * | 1989-10-31 | 1991-06-20 | Zeria Pharmaceut Co Ltd | Stable eye drop |
| JPH05286840A (en) * | 1992-04-11 | 1993-11-02 | Kaminomoto Honpo:Kk | Scalp cosmetic |
| JPH0847979A (en) * | 1994-08-05 | 1996-02-20 | Mitsui Petrochem Ind Ltd | Polyester bottle possible to re-fill |
-
2007
- 2007-04-13 JP JP2007105393A patent/JP5323324B2/en not_active Expired - Lifetime
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56101345A (en) * | 1980-01-17 | 1981-08-13 | Toshiba Corp | Stator of electric rotary machine |
| JPS6236367A (en) * | 1985-07-19 | 1987-02-17 | ヴインチエンツオ・ザツピア | Monoxidil salt, its production and external remedy or cosmetics containing said salt as effective component |
| JPH0240315A (en) * | 1988-06-17 | 1990-02-09 | L'oreal Sa | Composition based on amphoteric surfactant and pyrimidine derivative |
| JPH03145421A (en) * | 1989-10-31 | 1991-06-20 | Zeria Pharmaceut Co Ltd | Stable eye drop |
| JPH05286840A (en) * | 1992-04-11 | 1993-11-02 | Kaminomoto Honpo:Kk | Scalp cosmetic |
| JPH0847979A (en) * | 1994-08-05 | 1996-02-20 | Mitsui Petrochem Ind Ltd | Polyester bottle possible to re-fill |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017052756A (en) * | 2015-09-10 | 2017-03-16 | 大正製薬株式会社 | Minoxidil-containing formulation contained in pump container |
| CN115501178A (en) * | 2022-08-26 | 2022-12-23 | 山东京卫制药有限公司 | Stable liquid composition containing minoxidil and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| JP5323324B2 (en) | 2013-10-23 |
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