JPH1146849A - Container for minoxyzyl-blended hair tonic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prevent the colouring of the hair tonic blended with minoxidil, with the lapse of time, by substantially constituting the material of a container, which includes mninoxidil as a content of polyethylene terephthalate plastic. SOLUTION: The material of a container is a polyethylene terephthalate plastic mainly composed of a base polymer including not less than 50% of a polymer component using a terephthalic acid or a dimethyl ester thereof, and ethylene glycol as the starting materials. The plastic of a degree satisfying the standard reference of food additives, a ministerial ordinance related to dairy products or FDA standard in U.S.A can be used. The plastic of the other polyester can be blended, and any polyethylene terephthalate can be substantially used. The minoxidil has high pharmacological activity, so that the dose per day requires accuracy, so that a quantitative extraction type container is needed. The polyethylene terephthalate is also preferable for the quantitative extraction type container.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a container for a hair restorer containing minoxidil.

[0002]

2. Description of the Related Art Minoxidil has a chemical name of 6- (1-piperidinyl) -2,4-pyridinediamine-3-oxide, and its application as a hair restorer is described in U.S. Pat. No. 4,139,619. A hair restorer containing minoxidil is used worldwide and is used for treating alopecia. However, foreign products have a drawback that the preparation turns yellow over time, and the product value may be reduced during use, such as dirt on clothes and a reduced feeling of use. As a material of the hair restorer container containing minoxidil, PP (polypropylene) and PE (polyethylene) are used, but it is hard to say that the container is made of a preferable material because it is colored with time.

[0003] A polyethylene terephthalate plastic (PET) film is excellent in transparency and strength, and has expectations, moisture permeability and heat resistance. Widely used for large bottles such as cola drink containers, carbonated drinks, and soy sauce.

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to provide a stable container in which a hair restorer containing minoxidil does not discolor over time.

[0005] Discoloration of the contents can be suppressed to some extent by using a container of minoxidil which is made of a material that completely blocks light, but it is not possible to determine the discoloration of the contents.

On the other hand, a transparent material such as a glass container has a low light-shielding property and it is difficult to prevent discoloration with time. For this reason, minoxidil containers are commercially available as colored containers such as brown for shielding light, but there is a problem in formulation due to the large elution of metals and the like from ordinary colored glass. Further, the container coated with the inner surface of the container also had metal dissolution, which had a problem in the preparation.

[0007]

Means for Solving the Problems In view of the above-mentioned object, the present inventors consider that light is the main cause of the coloration of the preparation over time, and consider a container for preventing the influence of light having a wavelength specific to minoxidil. It was thought that the use of the compound could prevent the coloring of the preparation over time.

The inventors of the present invention have conducted intensive studies on a transparent container for preventing the influence of light based on the idea. As a result, they have found that the use of a container of a certain material can prevent the coloring of the preparation over time. Completed the invention.

That is, the present invention is a hair restorer containing minoxidil as a content, and the material of the container is substantially made of polyethylene terephthalate plastic. The material of the container of the present invention is a polyethylene terephthalate plastic (PET) containing as a main component a base polymer containing at least 50% of a polymerization component starting from terephthalic acid or its dimethyl ester and ethylene glycol.

[0010] Any standards may be used as long as they are stipulated in the standards for foods and additives, ministerial ordinances for milk, etc., and the US FDA standard (21 CFR). Other plastics such as polyester can be blended to the extent that the invention is not impaired, and it is sufficient that the material is substantially PET (polyethylene terephthalate).

Minoxidil has a high pharmacological activity, and it is necessary to make the daily dose accurate in order to obtain a sufficient hair restorer effect. PET (polyethylene terephthalate) is also preferable as the material of the main body of the metering-dispensing type. Particularly, regarding the material of the applicator portion, the measuring portion is selected from polyethylene, polypropylene, polyacetal, and polymethylpentene, and the application portion is dimethyl silicon. It is preferable from the viewpoint of hardness that the tube immersed in the container is made of polyethylene.

[0012] Further, in a single-use type unit dose container, polyethylene, which is generally easy to mold and has excellent squeezability, is used as a material, but in the case of a minoxidil preparation, there is a problem that coloring over time and evaporation of a solvent in the preparation are remarkable. was there.

However, if the above-mentioned PET (polyethylene terephthalate) is used, both coloring and evaporation of the solvent can be prevented.

[0014]

BEST MODE FOR CARRYING OUT THE INVENTION The container of the present invention can be used in a usual dosage form used as an external preparation for skin, for example, a lotion, an emulsion,
It is used as a container for storing formulations such as suspensions, tonics, creams and ointments. As components of the preparation, in addition to minoxidil, as long as the effects of the present invention are not impaired, antihistamines such as diphenhydramine hydrochloride and isopendyl hydrochloride, anti-inflammatory agents such as glycyrrhetinic acid and guaiazulene, keratolytic agents such as urea and salicylic acid, and chlorhexidine gluconate , Isopropylmethylphenol,
Fungicides such as quaternary ammonium salts, hinokitiol, pyroctonolamine, etc., moisturizing agents such as sodium hyaluronate, glycerin, chondroitin sulfate, yew, buttonpi, licorice, otrygisou, shrimp, loquat, kawamuragi, comfrey, ashitaba, saffron , Sansin, rosemary, sage, mock, mock, hop,
Plant and plant extracts such as placenta, vitamins such as retinol acetate, pyridoxine hydrochloride, ascorbic acid, thiamine nitrate, cyanocobalamin, biotin, tocopherol acetate, oils such as squalane, liquid paraffin, lecithin, and interfaces such as polyoxyethylene hydrogenated castor oil Activator,
It is also used as a container for preparations containing essential oil components such as menthol and camphor, antioxidants such as dibutylhydroxytoluene and isopropylgallate, sequestering agents such as ethylenediaminetetraacetate or salts thereof, pigments and flavors.

[0015]

According to the present invention, it has become possible to prevent the hair growth agent containing minoxidil from coloring over time.

[0016]

Hereinafter, the present invention will be described in detail with reference to test examples.

A hair restorer having the following formulation was prepared by a conventional method, filled in various containers, and subjected to a test. (Prescription) Minoxidil 1.0 g Propylene glycol 20.0 g Ethanol 60.0 ml Purified water Total 100.0 ml.

Test Example 1 (Effect of polyethylene terephthalate container on coloration of preparation over time) Hair growth components shown in the formulations of the examples were placed in containers made of various materials shown in Table 1, and were exposed to room temperature and sunlight near windows. After completion, the color of the preparation was evaluated by the absorbance at 420 nm. Table 1 shows the results.

[0019]

[Table 1]

Test Example 2 (Effect of Silica-Coated Brown Glass Container on Coloring of Preparation with Time) A hair growth component indicated in the formulation of the example was placed in a brown glass container whose inner surface was coated with silica, and indoor scattering light and room temperature were measured. After storage under conditions, the color of the preparation was measured by absorbance at 420 nm. Table 2 shows the results.

Under room temperature storage conditions close to normal use conditions,
When the coloring of the preparation is compared between the silica-coated brown glass and the normal brown glass, the absorbance of the 6M stock of the normal brown glass is 0.060, whereas the absorbance of the 6M stock of the silica-coated brown glass is 0. 01 (Table 2), which was clearly low, and almost no coloring was visually observed, indicating that the silica-coated brown glass container according to the present invention was suitable as a storage container for the minoxidil preparation.

[0022]

[Table 2]

Test Example 3 (Effect of Material of Quantitatively Pourable Type Container on Coloring of Preparation with Time) The hair restorer shown in the example was placed in a quantitatively dispenseable container composed of each applicator material, and each condition (room temperature, 40 ° C., 75 ° C.) % R
H) to 6 M, and after completion, color the formulation at 420 nm.
And the content of minoxidil as stability of the preparation were measured by liquid chromatography. The result is that, for the material of the applicator part, the metering part is low density polyethylene,
Selected from high density polyethylene, polypropylene, polyacetal, polymethylpentene, acrylic,
A little coloring of the acrylic was observed in the stability of the 6M storage product at 0 ° C. and 75% RH.

A container composed of dimethyl silicone for the coated portion and polyethylene for the tube immersed in the container is preferable because the coloring of the preparation with time is low.

Test Example 4 Effect of Aluminum Pillow Packaging in Unit Dose Container on Coloring and Volatilization of Formulation Over Time The hair restorer shown in Example was placed in two (0.5 ml, 2.0 ml) unit dose containers having different thicknesses and volumes. The degree of volatilization and coloring of the preparation over time was measured.

Storage conditions are room temperature, 40 ° C. and 50 ° C. at 4M.
After completion of the preparation, the coloring of the preparation was measured for absorbance at 420 nm and weight volatility. The result is that by volumizing aluminum pillows, the volatilization of the preparation is clearly suppressed and the coloring is extremely low, which is suitable for a storage container for the minoxidil preparation.

Test Example 5 Effect of Shrink Wrapping of Container The hair restorer shown in the examples was placed in a transparent glass container and a container in which the outside of the transparent glass container was shrink wrapped and stored at room temperature up to 6M. After completion, the coloring of the preparation was measured by measuring the absorbance at 420 nm. . As a result, the absorbance of the 6M preserved product can be lowered by shrink wrapping, and it is suitable as a container for minoxidil-containing hair restorer.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Hitoshi Tomizawa 3- 24-1, Takada, Toshima-ku, Tokyo Taisho Pharmaceutical Co., Ltd. (72) Inventor Shigeo Tanaka 3- 24-1, Takada, Toshima-ku, Tokyo Taisho Pharmaceutical Co., Ltd.

Claims (1)

[Claims] 1. A container for a hair restorer containing minoxidil, which is substantially made of polyethylene terephthalate plastic.